W-84


SMILES O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2
InChIKey WDAXQFXYXWPELC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 15
Molecular weight (Da) 548.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.85 6.61 7.5 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 6.34 6.65 6.83 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.6 7.6 7.6 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 6.0 6.75 7.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Pig Acetylcholine (muscarinic) A pEC50 5.84 6.25 7.87 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pEC50 6.0 6.0 6.0 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.32 6.32 6.32 ChEMBL