Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2274	3151	58	None	-724	37	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-724	37	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-724	37	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-724	37	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-724	37	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2600	3750	74	None	-389	32	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-389	32	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-389	32	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-389	32	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-389	32	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2520	203985	70	None	-26	20	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	203985	70	None	-26	20	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	203985	70	None	-26	20	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	72093	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-10	28	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4031	99285	28	None	-18	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99285	28	None	-18	12	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	1234	189197	56	None	-41	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189197	56	None	-41	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189197	56	None	-41	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	4452	2742	19	None	-162	21	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2742	19	None	-162	21	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2742	19	None	-162	21	Human	7.0	pAC50	=	7.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	1593	2325	66	None	-23	6	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668	2325	66	None	-23	6	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	9868	2325	66	None	-23	6	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL17860	2325	66	None	-23	6	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	DB04948	2325	66	None	-23	6	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	55645	84341	8	None	-389	11	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84341	8	None	-389	11	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	2477	742	59	None	-2	20	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	742	59	None	-2	20	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	742	59	None	-2	20	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	742	59	None	-2	20	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	742	59	None	-2	20	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	2372	106441	40	None	-51	6	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106441	40	None	-51	6	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	4418	34192	85	None	-1	18	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34192	85	None	-1	18	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	2448	99295	70	None	-54	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99295	70	None	-54	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	47936	193398	88	None	-25	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193398	88	None	-25	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	2869	4121	89	None	-4265	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4121	89	None	-4265	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4121	89	None	-4265	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4121	89	None	-4265	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4121	89	None	-4265	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	68617	205504	62	None	-34	30	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-34	30	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-34	30	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	4567	9916	34	None	-114	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9916	34	None	-114	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	2543	3681	68	None	-204	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3681	68	None	-204	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3681	68	None	-204	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3681	68	None	-204	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3681	68	None	-204	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	34633	5432	64	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	5	1	6	4.1	CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1075	5432	64	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	5	1	6	4.1	CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2162	41484	100	None	-15	22	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-15	22	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	2165	203760	71	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203760	71	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203760	71	None	-8	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3689	102744	55	None	-186	16	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102744	55	None	-186	16	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102744	55	None	-186	16	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	135398737	955	93	None	-295	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-295	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-295	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-295	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-295	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1212	1649	50	None	-1071	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1649	50	None	-1071	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1649	50	None	-1071	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1649	50	None	-1071	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1649	50	None	-1071	35	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	103	4122	61	None	-154	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-154	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-154	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-154	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-154	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	150	2492	21	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	-5	17	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	10531	1408	21	None	-48	26	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-48	26	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-48	26	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-48	26	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-48	26	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	212	3777	47	None	-309	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-309	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-309	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-309	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-309	22	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	71481097	120484	48	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
	CHEMBL3545185	120484	48	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	2	7	3.4	O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1	10.1038/s41467-023-40064-9
	187	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	255	39	None	-3	8	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4640	78237	30	None	-1	11	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78237	30	None	-1	11	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	213	3824	55	None	-125	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3824	55	None	-125	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3824	55	None	-125	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3824	55	None	-125	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3824	55	None	-125	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	4066	204603	78	None	-954	16	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204603	78	None	-954	16	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	1193	1643	108	None	-194	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	2447	1643	108	None	-194	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	3371	1643	108	None	-194	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL23588	1643	108	None	-194	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB02266	1643	108	None	-194	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	3	2	2	4.1	OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F	10.1038/s41467-023-40064-9
	135398737	955	93	None	-295	43	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-295	43	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-295	43	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-295	43	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-295	43	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	2389	3306	118	None	-812	29	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-812	29	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-812	29	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-812	29	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-812	29	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2470	3626	50	None	-3388	23	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-3388	23	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-3388	23	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-3388	23	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-3388	23	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2169	44817	35	None	-1	12	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44817	35	None	-1	12	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	118422671	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2737	65	None	-158	23	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	119570	3137	96	None	-10000	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3137	96	None	-10000	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3137	96	None	-10000	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3137	96	None	-10000	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3137	96	None	-10000	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2335	11816	22	None	-117	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-117	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-117	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-117	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	21722	17960	31	None	-27	21	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17960	31	None	-27	21	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	16231	207486	57	None	-4	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	CHEMBL945	207486	57	None	-4	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	37	775	60	None	-9	12	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-9	12	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-9	12	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-9	12	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-9	12	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	16363	593	53	None	-31	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-31	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-31	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-31	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-31	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3658	4076	53	None	-5	18	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	-5	18	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	-5	18	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	-5	18	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	-5	18	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	31101	726	40	None	-53	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-53	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-53	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-53	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-53	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-20	17	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-20	17	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-20	17	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-20	17	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2600	3750	74	None	-389	32	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-389	32	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-389	32	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-389	32	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-389	32	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	43815	186896	64	None	-169	20	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-169	20	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-169	20	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	2136	3073	30	None	-338	21	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3073	30	None	-338	21	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3073	30	None	-338	21	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3073	30	None	-338	21	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3073	30	None	-338	21	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	6018	11033	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11033	96	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	4011	82379	49	None	-2137	26	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82379	49	None	-2137	26	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	4993	122331	110	None	-4	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122331	110	None	-4	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	26248	161515	102	None	-1	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161515	102	None	-1	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	3157	1458	71	None	-17378	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-17378	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-17378	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-17378	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-17378	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2601	3751	33	None	-57	17	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-57	17	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-57	17	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-57	17	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-57	17	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	26987	946	33	None	-7079	34	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-7079	34	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-7079	34	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-7079	34	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-7079	34	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	107641	61113	78	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1765292	61113	78	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	129211	3722	78	None	-43	14	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3722	78	None	-43	14	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3722	78	None	-43	14	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3722	78	None	-43	14	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3722	78	None	-43	14	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	134	2497	24	None	-97	18	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2497	24	None	-97	18	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2497	24	None	-97	18	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2497	24	None	-97	18	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2497	24	None	-97	18	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1890	2739	49	None	-5	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-5	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-5	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-5	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-5	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	2202	3110	96	None	-338	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3110	96	None	-338	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3110	96	None	-338	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3110	96	None	-338	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3110	96	None	-338	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	2162	41484	100	None	-15	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-15	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	1549120	196463	85	None	-13	19	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56337	196463	85	None	-13	19	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	3149	12582	15	None	-60	26	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-60	26	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	1210	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	90475904	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	915	51	None	-2290	22	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	610479	15468	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15468	90	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	53276	95005	53	None	-1	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	CHEMBL255044	95005	53	None	-1	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	304	5	3	5	3.0	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N	10.1038/s41467-023-40064-9
	37264	189398	24	None	-14	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL513301	189398	24	None	-14	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	1043	1569	14	None	-1096	23	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1569	14	None	-1096	23	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1569	14	None	-1096	23	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1569	14	None	-1096	23	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1569	14	None	-1096	23	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	124087	1377	114	None	-363	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-363	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-363	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-363	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-363	27	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-107	19	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-107	19	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	5077	3552	79	None	-912	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3552	79	None	-912	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3552	79	None	-912	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3552	79	None	-912	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3552	79	None	-912	13	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2880	97980	49	None	-23	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	97980	49	None	-23	9	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	102	4096	48	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	2105	3032	37	None	-23	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-23	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-23	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-23	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-23	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	636403	188244	22	None	3	7	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188244	22	None	3	7	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	123606	351	70	None	-2089	6	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	351	70	None	-2089	6	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	351	70	None	-2089	6	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	351	70	None	-2089	6	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	351	70	None	-2089	6	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	392622	56282	95	None	-21	20	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56282	95	None	-21	20	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	1981	67433	96	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	6	1	6	3.5	COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL189171	67433	96	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	6	1	6	3.5	COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	25382	9125	37	None	-707	21	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-707	21	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	5288783	14401	50	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	5	3	3	5.1	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200666	14401	50	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	5	3	3	5.1	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)/C=C/[C@@H](O)C4CC4)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	157355	57478	47	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	8	9	11	-5.8	OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO	10.1038/s41467-023-40064-9
	CHEMBL1661	57478	47	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	8	9	11	-5.8	OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)CO	10.1038/s41467-023-40064-9
	2515	78221	57	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	283	7	3	7	0.8	CCOC(=O)NNc1ccc(N(CC)CC(C)O)nn1	10.1038/s41467-023-40064-9
	CHEMBL2106561	78221	57	None	-	1	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	283	7	3	7	0.8	CCOC(=O)NNc1ccc(N(CC)CC(C)O)nn1	10.1038/s41467-023-40064-9
	168871	89101	14	None	-20	13	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89101	14	None	-20	13	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	209	3035	97	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3035	97	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3035	97	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3035	97	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3035	97	None	-1174	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4940	14438	35	None	-91	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14438	35	None	-91	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	44112	121264	48	None	-3	12	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121264	48	None	-3	12	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	1816	2523	102	None	-4466	12	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2523	102	None	-4466	12	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2523	102	None	-4466	12	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2523	102	None	-4466	12	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2523	102	None	-4466	12	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	11504295	2902	47	None	-218776	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2902	47	None	-218776	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2902	47	None	-218776	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2902	47	None	-218776	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2902	47	None	-218776	8	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2467	67395	51	None	-6	5	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	CHEMBL188921	67395	51	None	-6	5	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	2247	504	81	None	-53	42	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-53	42	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-53	42	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-53	42	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-53	42	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	12582	947	45	None	-234	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783	947	45	None	-234	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	CHEMBL49080	947	45	None	-234	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	DB01407	947	45	None	-234	7	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	31101	726	40	None	-53	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-53	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-53	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-53	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-53	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	2337	3232	77	None	-10	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-10	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-10	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-10	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-10	29	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2393	3309	82	None	-173	9	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3309	82	None	-173	9	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3309	82	None	-173	9	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3309	82	None	-173	9	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3309	82	None	-173	9	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5090	15529	106	None	-1	3	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL122	15529	106	None	-1	3	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	10.1038/s41467-023-40064-9
	3158	56237	27	None	-3890	28	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-3890	28	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2220	3112	82	None	-398	17	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3112	82	None	-398	17	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3112	82	None	-398	17	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3112	82	None	-398	17	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3112	82	None	-398	17	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	9687	185311	25	None	-229	4	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	CHEMBL1522836	185311	25	None	-229	4	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	CHEMBL485980	185311	25	None	-229	4	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	7	2	11	1.7	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC	10.1038/s41467-023-40064-9
	47979	78181	59	None	-1202	9	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78181	59	None	-1202	9	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	2543	3681	68	None	-204	14	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3681	68	None	-204	14	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3681	68	None	-204	14	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3681	68	None	-204	14	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3681	68	None	-204	14	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	3899	207751	119	None	-478	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	1	3	3.3	Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL960	207751	119	None	-478	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	2	1	3	3.3	Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	2585	800	103	None	-36	34	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-36	34	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-36	34	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-36	34	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-36	34	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	242	469	124	None	-31	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-31	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-31	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-31	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-31	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	33624	3792	34	None	-5495	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	4061	3792	34	None	-5495	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	565	3792	34	None	-5495	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL499	3792	34	None	-5495	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	DB00373	3792	34	None	-5495	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	316	6	2	8	0.5	O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C	10.1038/s41467-023-40064-9
	19675	51640	43	None	-3	15	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51640	43	None	-3	15	Human	7.4	pAC50	=	7.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2318	154832	29	None	-6	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	-6	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	100	3776	58	None	-162	38	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-162	38	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-162	38	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-162	38	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-162	38	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	135	2515	43	None	-354	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-354	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-354	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-354	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-354	33	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	11658860	2329	51	None	-380	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2329	51	None	-380	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2329	51	None	-380	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2329	51	None	-380	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2329	51	None	-380	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2726	916	68	None	-2089	42	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-2089	42	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-2089	42	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-2089	42	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-2089	42	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	137	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	369	52	None	-162	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	118985385	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	1258	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	3440	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	4839	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL35	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB00695	1688	111	None	-7	2	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	330	5	3	5	1.9	OC(=O)c1cc(c(cc1NCc1ccco1)Cl)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2435	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	719	100	None	-1548	10	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	135398744	68633	86	None	-151	5	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	7	1	8	1.6	CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12	10.1038/s41467-023-40064-9
	CHEMBL192	68633	86	None	-151	5	Human	4.3	pAC50	=	4.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	7	1	8	1.6	CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12	10.1038/s41467-023-40064-9
	2540	4369	111	None	-741	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4369	111	None	-741	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	228	444	28	None	-1412	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	444	28	None	-1412	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	444	28	None	-1412	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	444	28	None	-1412	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	444	28	None	-1412	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	1343	1876	62	None	-616	12	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1876	62	None	-616	12	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1876	62	None	-616	12	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1876	62	None	-616	12	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1876	62	None	-616	12	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	2419	3437	84	None	-11481	14	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3437	84	None	-11481	14	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3437	84	None	-11481	14	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3437	84	None	-11481	14	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3437	84	None	-11481	14	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	3294	1993	111	None	-81	23	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-81	23	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-81	23	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-81	23	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-81	23	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	82153	43871	45	None	-11	3	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	CHEMBL1512	43871	45	None	-11	3	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	4659569	22299	101	None	-4	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	273	3	2	5	2.5	Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1324	22299	101	None	-4	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	273	3	2	5	2.5	Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc1	10.1038/s41467-023-40064-9
	5991	203896	72	None	1	9	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	203896	72	None	1	9	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	45138674	16614	50	None	-3	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16614	50	None	-3	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	2551	791	23	None	-56	13	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	791	23	None	-56	13	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	791	23	None	-56	13	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	791	23	None	-56	13	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	791	23	None	-56	13	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	180	400	56	None	-4265	38	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-4265	38	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-4265	38	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-4265	38	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-4265	38	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	71731823	111678	61	None	-5	3	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111678	61	None	-5	3	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	213046	2370	59	None	-2	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-2	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-2	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-2	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-2	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	5311507	194792	41	None	-562	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194792	41	None	-562	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	12574	2587	88	None	-104	8	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	2587	88	None	-104	8	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	2587	88	None	-104	8	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	2587	88	None	-104	8	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	2407	3347	76	None	-204	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3347	76	None	-204	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3347	76	None	-204	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3347	76	None	-204	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3347	76	None	-204	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	2470	3626	50	None	-3388	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-3388	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-3388	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-3388	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-3388	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5591	157507	90	None	-8	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	-8	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	17676	7040	29	None	-1	13	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7040	29	None	-1	13	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7040	29	None	-1	13	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	214	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-776	28	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	5803	162203	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162203	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	3151	1450	97	None	-2691	24	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1450	97	None	-2691	24	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1450	97	None	-2691	24	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1450	97	None	-2691	24	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1450	97	None	-2691	24	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2142	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3074	58	None	-891	18	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1971	2846	38	None	-10964	32	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-10964	32	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-10964	32	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-10964	32	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-10964	32	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	8730	195868	72	None	-1	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	195868	72	None	-1	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	195868	72	None	-1	5	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	2713	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-16	27	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-61	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-61	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-61	36	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	2583	205871	51	None	-8709	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	CHEMBL839	205871	51	None	-8709	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	292	5	3	4	1.7	CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2	10.1038/s41467-023-40064-9
	202	1496	77	None	-6	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-6	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-6	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-6	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-6	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	124	2960	47	None	-12	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2960	47	None	-12	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2960	47	None	-12	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2960	47	None	-12	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2960	47	None	-12	25	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-48	15	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-48	15	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-48	15	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-48	15	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	4746	204868	31	None	-8	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204868	31	None	-8	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204868	31	None	-8	19	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	71927	78374	18	None	2	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2106667	78374	18	None	2	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2110922	78374	18	None	2	2	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	4046	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2176	3104	68	None	-34	8	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	4828	3104	68	None	-34	8	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	91	3104	68	None	-34	8	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL500	3104	68	None	-34	8	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00960	3104	68	None	-34	8	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	10.1038/s41467-023-40064-9
	165193	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	2303	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	62882	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	66366	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3165	68	None	-363	20	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-20	17	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	2865	4112	73	None	-8	20	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-8	20	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-8	20	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-8	20	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-8	20	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	1353	1898	93	None	-446	39	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-446	39	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-446	39	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-446	39	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-446	39	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	10324985	76752	8	None	-	1	Human	11.0	pEC50	=	11	Functional	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76752	8	None	-	1	Human	11.0	pEC50	=	11	Functional	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76752	8	None	-	1	Human	11.0	pEC50	=	11	Functional	Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationAgonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	132257058	180885	0	None	-	1	Human	10.9	pEC50	=	10.9	Functional	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	CHEMBL4757755	180885	0	None	-	1	Human	10.9	pEC50	=	10.9	Functional	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	449	7	2	4	4.1	O=C(c1ccc(F)c(Cl)c1)N1CCC(F)(CNCCOc2cccc3c2CCN3)CC1	10.1021/acs.jmedchem.0c00814
	132247312	180631	0	None	-	1	Human	10.9	pEC50	=	10.9	Functional	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	CHEMBL4755058	180631	0	None	-	1	Human	10.9	pEC50	=	10.9	Functional	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	465	8	2	4	4.1	CC(=O)Nc1cccc(OCCNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)c1	10.1021/acs.jmedchem.0c00814
	24804775	19311	0	None	31	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	CHEMBL1290716	19311	0	None	31	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay	ChEMBL	412	4	0	5	3.8	Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1	10.1016/j.bmcl.2010.09.085
	10324985	76752	8	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL199824	76752	8	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	CHEMBL2068762	76752	8	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S bindingAgonistic activity at human 5HT1A receptor by [35S]GTP-gamma-S binding	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
	132247307	180386	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assayBiased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after 40 mins by LANCE Ultra cAMP kit-based TR-FRET assay	ChEMBL	481	8	2	4	4.6	C

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Main reference

Ligand source activities (1 row/activity)