Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

46780481 107531 20 None 3 15 Human 9.7 pAC50 = 9.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
9903970 107531 20 None 3 15 Human 9.7 pAC50 = 9.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
CHEMBL3187365 107531 20 None 3 15 Human 9.7 pAC50 = 9.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
CHEMBL3544974 107531 20 None 3 15 Human 9.7 pAC50 = 9.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 10.1038/s41467-023-40064-9
4940 14470 35 None -5 15 Human 6.0 pAC50 = 6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1201210 14470 35 None -5 15 Human 6.0 pAC50 = 6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 340 5 0 4 4.8 CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2 10.1038/s41467-023-40064-9
16351 102730 47 None -162 17 Human 6.0 pAC50 = 6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
CHEMBL304902 102730 47 None -162 17 Human 6.0 pAC50 = 6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 0 0 4 4.1 CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 5.0 pAC50 = 5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 5.0 pAC50 = 5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 5.0 pAC50 = 5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 5.0 pAC50 = 5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
1427 2013 54 None -933 30 Human 5.0 pAC50 = 5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
357 2013 54 None -933 30 Human 5.0 pAC50 = 5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3696 2013 54 None -933 30 Human 5.0 pAC50 = 5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL11 2013 54 None -933 30 Human 5.0 pAC50 = 5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00458 2013 54 None -933 30 Human 5.0 pAC50 = 5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2543 3707 68 None -691 14 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
5358 3707 68 None -691 14 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
54 3707 68 None -691 14 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
CHEMBL128 3707 68 None -691 14 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
DB00669 3707 68 None -691 14 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 10.1038/s41467-023-40064-9
2247 505 81 None -23 42 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 505 81 None -23 42 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 505 81 None -23 42 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 505 81 None -23 42 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 505 81 None -23 42 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
104870 98880 47 None -56 10 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
5374 98880 47 None -56 10 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
CHEMBL279085 98880 47 None -56 10 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
4178 195803 63 None -3 2 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 179 3 1 2 2.0 Cc1cccc(C)c1OCC(C)N 10.1038/s41467-023-40064-9
CHEMBL558 195803 63 None -3 2 Human 5.0 pAC50 = 5.0 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 179 3 1 2 2.0 Cc1cccc(C)c1OCC(C)N 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
54682461 84686 62 None -2 12 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
CHEMBL222559 84686 62 None -2 12 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
2520 204008 70 None -10 20 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
CHEMBL1280 204008 70 None -10 20 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
CHEMBL6966 204008 70 None -10 20 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
26987 949 33 None -104 34 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
6063 949 33 None -104 34 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
671 949 33 None -104 34 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
CHEMBL1626 949 33 None -104 34 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
DB00283 949 33 None -104 34 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C 10.1038/s41467-023-40064-9
1222 1664 49 None -5 25 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3396 1664 49 None -5 25 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
85 1664 49 None -5 25 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL46516 1664 49 None -5 25 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
DB04842 1664 49 None -5 25 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
4993 122357 110 None -1 5 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 248 2 2 4 2.5 CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL36 122357 110 None -1 5 Human 5.0 pAC50 = 5.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 248 2 2 4 2.5 CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1 10.1038/s41467-023-40064-9
242 470 124 None -229 33 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 124 None -229 33 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 124 None -229 33 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 124 None -229 33 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 124 None -229 33 Human 6.0 pAC50 = 6.0 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
71496458 115564 87 None -3 16 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
CHEMBL3353410 115564 87 None -3 16 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 499 10 2 8 4.5 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C 10.1038/s41467-023-40064-9
447715 196927 68 None -19 7 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL566315 196927 68 None -19 7 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1038/s41467-023-40064-9
4452 2762 19 None -85 21 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
983 2762 19 None -85 21 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
CHEMBL20734 2762 19 None -85 21 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 387 6 2 4 3.8 COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl 10.1038/s41467-023-40064-9
16363 596 53 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
312 596 53 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
9215 596 53 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL297302 596 53 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB12867 596 53 None -3 21 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 6 1 4 3.8 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
135398737 958 93 None -6 43 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
38 958 93 None -6 43 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
722 958 93 None -6 43 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL42 958 93 None -6 43 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
DB00363 958 93 None -6 43 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1038/s41467-023-40064-9
1385580 29276 76 None -141 19 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 29276 76 None -141 19 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 29276 76 None -141 19 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
2402 3370 62 None -27 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
5095 3370 62 None -27 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
7295 3370 62 None -27 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
CHEMBL589 3370 62 None -27 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
DB00268 3370 62 None -27 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O 10.1038/s41467-023-40064-9
216416 111581 48 None -141 23 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 111581 48 None -141 23 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
16960 14487 23 None -1905 7 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 318 5 0 2 3.9 CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
CHEMBL1201287 14487 23 None -1905 7 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 318 5 0 2 3.9 CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
11504295 2923 47 None -97723 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
4814 2923 47 None -97723 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
7543 2923 47 None -97723 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
CHEMBL605846 2923 47 None -97723 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
DB09080 2923 47 None -97723 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1038/s41467-023-40064-9
123606 352 70 None -1071 6 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
128 352 70 None -1071 6 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
7110 352 70 None -1071 6 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
CHEMBL1505 352 70 None -1071 6 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
DB00918 352 70 None -1071 6 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 335 6 1 3 2.2 CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C 10.1038/s41467-023-40064-9
2333 142335 97 None -14 14 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142335 97 None -14 14 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
2162 41514 100 None -11 22 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1491 41514 100 None -11 22 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1038/s41467-023-40064-9
71398 106439 44 None -2290 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 106439 44 None -2290 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
91610 141353 96 None -1 2 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 527 7 2 6 3.5 COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C 10.1038/s41467-023-40064-9
CHEMBL383634 141353 96 None -1 2 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 527 7 2 6 3.5 COc1ccc2c(c1)C(=O)N(CCc1ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc1)C(=O)C2(C)C 10.1038/s41467-023-40064-9
11626560 200937 94 None -6 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
CHEMBL601719 200937 94 None -6 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
1212 1662 50 None -14 35 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
204 1662 50 None -14 35 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
3372 1662 50 None -14 35 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL726 1662 50 None -14 35 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00623 1662 50 None -14 35 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
212 3806 47 None -141 22 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 3806 47 None -141 22 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 3806 47 None -141 22 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 3806 47 None -141 22 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 3806 47 None -141 22 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
31101 729 40 None -26 29 Human 5.9 pAC50 = 5.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
35 729 40 None -26 29 Human 5.9 pAC50 = 5.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
403 729 40 None -26 29 Human 5.9 pAC50 = 5.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
CHEMBL493 729 40 None -26 29 Human 5.9 pAC50 = 5.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
DB01200 729 40 None -26 29 Human 5.9 pAC50 = 5.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C 10.1038/s41467-023-40064-9
134 2514 24 None -12 18 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
1775 2514 24 None -12 18 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
9681 2514 24 None -12 18 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
CHEMBL1065 2514 24 None -12 18 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
DB00247 2514 24 None -12 18 Human 6.9 pAC50 = 6.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO 10.1038/s41467-023-40064-9
1613 2348 53 None -2 34 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
205 2348 53 None -2 34 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
3964 2348 53 None -2 34 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL831 2348 53 None -2 34 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00408 2348 53 None -2 34 Human 6.9 pAC50 = 6.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
1890 2759 49 None -1 24 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 2759 49 None -1 24 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 2759 49 None -1 24 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 2759 49 None -1 24 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 2759 49 None -1 24 Human 5.9 pAC50 = 5.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
2869 4152 89 None -5011 5 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10.1038/s41467-023-40064-9
60 4152 89 None -5011 5 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10.1038/s41467-023-40064-9
60857 4152 89 None -5011 5 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10.1038/s41467-023-40064-9
CHEMBL1185 4152 89 None -5011 5 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10.1038/s41467-023-40064-9
DB00315 4152 89 None -5011 5 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 5 2 3 1.9 CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C 10.1038/s41467-023-40064-9
31703 194717 63 None -8 8 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL359744 194717 63 None -8 8 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
CHEMBL53463 194717 63 None -8 8 Human 4.9 pAC50 = 4.9 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 543 5 6 12 0.0 COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 10.1038/s41467-023-40064-9
21722 17992 31 None -9 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 2 4.3 CN(C)CCCn1c2c(c3ccccc31)CCCCCC2 10.1038/s41467-023-40064-9
CHEMBL126224 17992 31 None -9 21 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 2 4.3 CN(C)CCCn1c2c(c3ccccc31)CCCCCC2 10.1038/s41467-023-40064-9
65700 78260 28 None -41 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 238 1 1 2 3.3 CNC1Cc2ccccc2N(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL2106919 78260 28 None -41 8 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 238 1 1 2 3.3 CNC1Cc2ccccc2N(C)c2ccccc21 10.1038/s41467-023-40064-9
3081361 93934 123 None -22 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
CHEMBL24828 93934 123 None -22 14 Human 4.9 pAC50 = 4.9 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 474 5 1 5 4.4 COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 10.1038/s41467-023-40064-9
135409453 3773 41 None -173 35 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3773 41 None -173 35 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3773 41 None -173 35 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
610479 15500 90 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 261 3 2 2 4.1 Cc1c(Cl)cccc1Nc1ccccc1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL121626 15500 90 None -1 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 261 3 2 2 4.1 Cc1c(Cl)cccc1Nc1ccccc1C(=O)O 10.1038/s41467-023-40064-9
41684 31221 105 None -33 32 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31221 105 None -33 32 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
2782 32000 67 None -4466 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
CHEMBL1407943 32000 67 None -4466 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
CHEMBL3216363 32000 67 None -4466 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 325 4 0 3 4.3 Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 10.1038/s41467-023-40064-9
21772 78399 31 None -1000 10 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 293 4 0 1 4.5 CC(CC1c2ccccc2CCc2ccccc21)CN(C)C 10.1038/s41467-023-40064-9
CHEMBL2110816 78399 31 None -1000 10 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 293 4 0 1 4.5 CC(CC1c2ccccc2CCc2ccccc21)CN(C)C 10.1038/s41467-023-40064-9
4528 98126 80 None -6 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 238 1 1 2 2.8 CN1Cc2c(N)cccc2C(c2ccccc2)C1 10.1038/s41467-023-40064-9
CHEMBL273575 98126 80 None -6 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 238 1 1 2 2.8 CN1Cc2c(N)cccc2C(c2ccccc2)C1 10.1038/s41467-023-40064-9
1201549 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
333 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
7601 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201203 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL438151 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
DB00245 597 24 None -97 26 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
2342 599 39 None -3 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
331 599 39 None -3 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
7124 599 39 None -3 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
CHEMBL1201250 599 39 None -3 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
DB00767 599 39 None -3 8 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 404 6 0 6 2.4 CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC 10.1038/s41467-023-40064-9
1353 1911 93 None -77 39 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1911 93 None -77 39 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1911 93 None -77 39 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1911 93 None -77 39 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1911 93 None -77 39 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
2583 3776 118 None -8912 16 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3776 118 None -8912 16 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3776 118 None -8912 16 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3776 118 None -8912 16 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3776 118 None -8912 16 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
124087 1389 114 None -2 27 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
7157 1389 114 None -2 27 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
814 1389 114 None -2 27 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
CHEMBL1172 1389 114 None -2 27 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
DB00967 1389 114 None -2 27 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 0 1 2 4.0 Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1 10.1038/s41467-023-40064-9
5440 28724 37 None -512 16 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1378 28724 37 None -512 16 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 399 6 0 5 5.0 CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
3926 207241 40 None -2 18 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 207241 40 None -2 18 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
2142 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
4920903 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
502 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
5775 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
CHEMBL597 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
DB00692 3096 58 None -223 18 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1038/s41467-023-40064-9
5077 3578 79 None -602 13 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
7552 3578 79 None -602 13 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767 3578 79 None -602 13 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL238804 3578 79 None -602 13 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
DB11362 3578 79 None -602 13 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
60606 61560 73 None -7 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 321 3 0 4 3.7 COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1 10.1038/s41467-023-40064-9
CHEMBL1771 61560 73 None -7 8 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 321 3 0 4 3.7 COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1 10.1038/s41467-023-40064-9
46199646 120507 69 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 520 8 4 7 3.4 CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO 10.1038/s41467-023-40064-9
CHEMBL3544914 120507 69 None - 1 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 520 8 4 7 3.4 CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1C[C@@H](O)CO 10.1038/s41467-023-40064-9
5666 102992 35 None -7 5 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 237 5 1 4 1.5 CCOc1ccccc1OCC1CNCCO1 10.1038/s41467-023-40064-9
CHEMBL306700 102992 35 None -7 5 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 237 5 1 4 1.5 CCOc1ccccc1OCC1CNCCO1 10.1038/s41467-023-40064-9
1224 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
3100 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
8980 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
916 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
CHEMBL657 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
DB01075 1432 83 None -912 22 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 255 6 0 2 3.4 CN(CCOC(c1ccccc1)c1ccccc1)C 10.1038/s41467-023-40064-9
3704 78189 41 None -3 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 231 3 1 3 1.6 C1=Cc2cccc(OCC3CNCCO3)c2C1 10.1038/s41467-023-40064-9
CHEMBL2105022 78189 41 None -3 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 231 3 1 3 1.6 C1=Cc2cccc(OCC3CNCCO3)c2C1 10.1038/s41467-023-40064-9
3198 205513 76 None -29 37 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1201049 205513 76 None -29 37 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL808 205513 76 None -29 37 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
4746 204891 31 None -15 19 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL1334033 204891 31 None -15 19 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
CHEMBL75880 204891 31 None -15 19 Human 4.8 pAC50 = 4.8 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 277 4 1 1 5.3 C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1 10.1038/s41467-023-40064-9
228 445 28 None -316 20 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
33 445 28 None -316 20 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005 445 28 None -316 20 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
CHEMBL53 445 28 None -316 20 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
DB00714 445 28 None -316 20 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
10034073 17161 29 None -3 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 17161 29 None -3 4 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
445643 97389 69 None -2 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
CHEMBL269732 97389 69 None -2 7 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 803 7 3 12 4.6 C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC 10.1038/s41467-023-40064-9
2378 98687 103 None -34 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 4 0 2 5.2 c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1 10.1038/s41467-023-40064-9
CHEMBL277535 98687 103 None -34 5 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 310 4 0 2 5.2 c1ccc(-c2ccc(C(c3ccccc3)n3ccnc3)cc2)cc1 10.1038/s41467-023-40064-9
50905713 102396 76 None -1 2 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 416 4 2 6 4.5 C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL3039502 102396 76 None -1 2 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 416 4 2 6 4.5 C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 10.1038/s41467-023-40064-9
26248 161539 102 None -1 11 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
CHEMBL41286 161539 102 None -1 11 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 368 3 1 7 2.0 CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O 10.1038/s41467-023-40064-9
47936 193422 88 None -380 6 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 2 3 7 1.5 C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C 10.1038/s41467-023-40064-9
CHEMBL52606 193422 88 None -380 6 Human 4.8 pAC50 = 4.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 2 3 7 1.5 C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C 10.1038/s41467-023-40064-9
2448 99323 70 None -81 15 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
CHEMBL28218 99323 70 None -81 15 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 419 6 1 3 4.5 O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1 10.1038/s41467-023-40064-9
4976 203579 29 None -199 15 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL668 203579 29 None -199 15 Human 5.8 pAC50 = 5.8 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 263 4 1 1 4.3 CNCCCC1c2ccccc2C=Cc2ccccc21 10.1038/s41467-023-40064-9
2713 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 205271 82 None -3 27 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
2855 4132 104 None -9549 12 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3322 4132 104 None -9549 12 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717 4132 104 None -9549 12 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL603 4132 104 None -9549 12 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
DB00549 4132 104 None -9549 12 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5482 14420 80 None -10 13 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1200438 14420 80 None -10 13 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 386 6 0 4 5.9 Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 10.1038/s41467-023-40064-9
6127 14499 8 None -117 6 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 278 2 0 0 4.4 C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL1201340 14499 8 None -117 6 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 278 2 0 0 4.4 C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
3823 50221 42 None -47 15 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
76973198 50221 42 None -47 15 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL157101 50221 42 None -47 15 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 10.1038/s41467-023-40064-9
2995 204405 53 None -7079 18 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1696 204405 53 None -7079 18 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL72 204405 53 None -7079 18 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 10.1038/s41467-023-40064-9
154257 178619 67 None -8 19 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
CHEMBL46740 178619 67 None -8 19 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 470 7 2 5 6.3 Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 10.1038/s41467-023-40064-9
2389 3331 118 None -1 29 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
5073 3331 118 None -1 29 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
96 3331 118 None -1 29 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
CHEMBL85 3331 118 None -1 29 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
DB00734 3331 118 None -1 29 Human 8.6 pAC50 = 8.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1038/s41467-023-40064-9
2335 11848 22 None -3 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11848 22 None -3 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11848 22 None -3 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11848 22 None -3 34 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
3158 56267 27 None -194 28 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
CHEMBL1628227 56267 27 None -194 28 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 10.1038/s41467-023-40064-9
202 1508 77 None -2 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
60835 1508 77 None -2 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
972 1508 77 None -2 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1175 1508 77 None -2 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
DB00476 1508 77 None -2 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 10.1038/s41467-023-40064-9
3062316 33575 121 None 1 10 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 487 7 3 9 3.3 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 10.1038/s41467-023-40064-9
CHEMBL1421 33575 121 None 1 10 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 487 7 3 9 3.3 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 10.1038/s41467-023-40064-9
2333 142335 97 None -14 14 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142335 97 None -14 14 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
11658860 2344 51 None -17 11 Human 6.7 pAC50 = 6.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
2941 2344 51 None -17 11 Human 6.7 pAC50 = 6.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
4374 2344 51 None -17 11 Human 6.7 pAC50 = 6.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
CHEMBL360328 2344 51 None -17 11 Human 6.7 pAC50 = 6.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
DB04871 2344 51 None -17 11 Human 6.7 pAC50 = 6.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2 10.1038/s41467-023-40064-9
3658 4107 53 None -57 18 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
517 4107 53 None -57 18 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
5709 4107 53 None -57 18 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL312448 4107 53 None -57 18 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
DB06694 4107 53 None -57 18 Human 6.7 pAC50 = 6.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
47510 172546 39 None -13 3 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 220 1 3 2 1.4 CN=C(N)NC(=O)Nc1c(C)cccc1C 10.1038/s41467-023-40064-9
CHEMBL448416 172546 39 None -13 3 Human 4.7 pAC50 = 4.7 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 220 1 3 2 1.4 CN=C(N)NC(=O)Nc1c(C)cccc1C 10.1038/s41467-023-40064-9
3949 100614 50 None -22 16 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL29188 100614 50 None -22 16 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 468 8 0 5 4.9 COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC 10.1038/s41467-023-40064-9
71398 106439 44 None -2290 14 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
CHEMBL313972 106439 44 None -2290 14 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 10.1038/s41467-023-40064-9
4046 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
4252 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
CHEMBL416956 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
DB00358 2483 33 None -19 17 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 378 2 2 3 4.4 OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1 10.1038/s41467-023-40064-9
2351 4300 49 None -9 22 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1008 4300 49 None -9 22 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
CHEMBL1257078 4300 49 None -9 22 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 10.1038/s41467-023-40064-9
5311017 120604 11 None -32 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 239 5 0 1 3.8 C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL3545985 120604 11 None -32 5 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 239 5 0 1 3.8 C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1 10.1038/s41467-023-40064-9
636403 188268 22 None -8 7 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 570 5 2 5 6.8 CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 10.1038/s41467-023-40064-9
CHEMBL499915 188268 22 None -8 7 Human 4.7 pAC50 = 4.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 570 5 2 5 6.8 CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 10.1038/s41467-023-40064-9
48041 107081 46 None 1 6 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 352 6 1 3 4.4 COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1 10.1038/s41467-023-40064-9
CHEMBL315838 107081 46 None 1 6 Human 5.7 pAC50 = 5.7 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 352 6 1 3 4.4 COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1 10.1038/s41467-023-40064-9
213046 2385 59 None -1 17 Human 7.6 pAC50 = 7.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
4168 2385 59 None -1 17 Human 7.6 pAC50 = 7.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
7461 2385 59 None -1 17 Human 7.6 pAC50 = 7.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
CHEMBL1237021 2385 59 None -1 17 Human 7.6 pAC50 = 7.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
DB08815 2385 59 None -1 17 Human 7.6 pAC50 = 7.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1 10.1038/s41467-023-40064-9
2136 3095 30 None -45 21 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
4768 3095 30 None -45 21 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
7268 3095 30 None -45 21 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL753 3095 30 None -45 21 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
DB00925 3095 30 None -45 21 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 10.1038/s41467-023-40064-9
54454 5258 88 None 1 14 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5258 88 None 1 14 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
3157 1470 71 None -10232 21 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 1470 71 None -10232 21 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 1470 71 None -10232 21 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 1470 71 None -10232 21 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 1470 71 None -10232 21 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
1830 2590 44 None -416 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
207 2590 44 None -416 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
23897 2590 44 None -416 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
CHEMBL460 2590 44 None -416 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
DB01618 2590 44 None -416 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 10.1038/s41467-023-40064-9
10184665 3991 51 None -13489 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
4799 3991 51 None -13489 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
7353 3991 51 None -13489 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
CHEMBL1198857 3991 51 None -13489 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
DB09082 3991 51 None -13489 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 485 16 4 6 4.6 OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O 10.1038/s41467-023-40064-9
3658 4107 53 None -57 18 Human 6.6 pAC50 = 6.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
517 4107 53 None -57 18 Human 6.6 pAC50 = 6.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
5709 4107 53 None -57 18 Human 6.6 pAC50 = 6.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
CHEMBL312448 4107 53 None -57 18 Human 6.6 pAC50 = 6.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
DB06694 4107 53 None -57 18 Human 6.6 pAC50 = 6.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 10.1038/s41467-023-40064-9
119570 3159 96 None -426 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N 10.1038/s41467-023-40064-9
2233 3159 96 None -426 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N 10.1038/s41467-023-40064-9
953 3159 96 None -426 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N 10.1038/s41467-023-40064-9
CHEMBL301265 3159 96 None -426 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N 10.1038/s41467-023-40064-9
DB00413 3159 96 None -426 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N 10.1038/s41467-023-40064-9
9911830 19148 100 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 454 6 2 7 5.6 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL1289494 19148 100 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 454 6 2 7 5.6 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC 10.1038/s41467-023-40064-9
68873 43564 64 None -1 3 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 366 0 0 3 4.3 C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12 10.1038/s41467-023-40064-9
CHEMBL1509 43564 64 None -1 3 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 366 0 0 3 4.3 C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12 10.1038/s41467-023-40064-9
47979 78210 59 None -7943 9 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 8 2 6 0.7 C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC 10.1038/s41467-023-40064-9
CHEMBL2105581 78210 59 None -7943 9 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 8 2 6 0.7 C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC 10.1038/s41467-023-40064-9
104870 98880 47 None -56 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
5374 98880 47 None -56 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
CHEMBL279085 98880 47 None -56 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 10.1038/s41467-023-40064-9
4031 99313 28 None -39 12 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
CHEMBL282121 99313 28 None -39 12 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 429 13 0 6 4.6 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1 10.1038/s41467-023-40064-9
102 4127 48 None -549 20 Human 5.6 pAC50 = 5.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
3659 4127 48 None -549 20 Human 5.6 pAC50 = 5.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
8969 4127 48 None -549 20 Human 5.6 pAC50 = 5.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
CHEMBL15245 4127 48 None -549 20 Human 5.6 pAC50 = 5.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
DB01392 4127 48 None -549 20 Human 5.6 pAC50 = 5.6 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1038/s41467-023-40064-9
45138674 16646 50 None -1 6 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 572 6 1 7 5.7 COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 10.1038/s41467-023-40064-9
CHEMBL1241951 16646 50 None -1 6 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 572 6 1 7 5.7 COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1 10.1038/s41467-023-40064-9
4011 82408 49 None -46 26 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
CHEMBL21731 82408 49 None -46 26 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 10.1038/s41467-023-40064-9
2780 110529 36 None -251 11 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 5 2 4 3.3 COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL325109 110529 36 None -251 11 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 5 2 4 3.3 COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1 10.1038/s41467-023-40064-9
2284 3182 33 None -16 34 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
4926 3182 33 None -16 34 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
7281 3182 33 None -16 34 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL564 3182 33 None -16 34 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00420 3182 33 None -16 34 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C 10.1038/s41467-023-40064-9
2286 3183 51 None -20 28 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
4927 3183 51 None -20 28 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
7282 3183 51 None -20 28 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
CHEMBL643 3183 51 None -20 28 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
DB01069 3183 51 None -20 28 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C 10.1038/s41467-023-40064-9
60753 194684 40 None -7 6 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 384 14 2 4 4.2 CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL533 194684 40 None -7 6 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 384 14 2 4 4.2 CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
4942 5718 50 None -31 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1078261 5718 50 None -31 11 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 367 7 0 4 4.0 CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1 10.1038/s41467-023-40064-9
2264 53190 38 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 349 2 1 4 1.5 CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21 10.1038/s41467-023-40064-9
CHEMBL1598608 53190 38 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 349 2 1 4 1.5 CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21 10.1038/s41467-023-40064-9
2351 3286 64 None -457 27 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
2820 3286 64 None -457 27 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
5035 3286 64 None -457 27 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
CHEMBL81 3286 64 None -457 27 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
DB00481 3286 64 None -457 27 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 10.1038/s41467-023-40064-9
5994 4641 88 None -9 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
CHEMBL103 4641 88 None -9 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1038/s41467-023-40064-9
64139 84785 96 None -2 9 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84785 96 None -2 9 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
43815 186920 64 None -102 20 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 186920 64 None -102 20 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 186920 64 None -102 20 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
5591 157531 90 None -1 17 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157531 90 None -1 17 Human 5.6 pAC50 = 5.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
1056 3371 116 None -51 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
2405 3371 116 None -51 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
77999 3371 116 None -51 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
CHEMBL121 3371 116 None -51 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
DB00412 3371 116 None -51 10 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
46220502 112583 84 None -91 4 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 506 7 1 8 4.9 CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 10.1038/s41467-023-40064-9
CHEMBL3301610 112583 84 None -91 4 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 506 7 1 8 4.9 CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 10.1038/s41467-023-40064-9
9417 133512 54 None -346 15 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL1524185 133512 54 None -346 15 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
CHEMBL370753 133512 54 None -346 15 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 363 6 1 4 3.3 OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1 10.1038/s41467-023-40064-9
54684141 208000 82 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 270 2 2 3 3.0 C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL973 208000 82 None -1 2 Human 4.6 pAC50 = 4.6 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 270 2 2 3 3.0 C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
2218 15283 23 None -3 12 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 322 8 0 2 4.4 CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1 10.1038/s41467-023-40064-9
CHEMBL1213033 15283 23 None -3 12 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 322 8 0 2 4.4 CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1 10.1038/s41467-023-40064-9
72106 78192 60 None 3 3 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 6 3.3 O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1 10.1038/s41467-023-40064-9
CHEMBL2105059 78192 60 None 3 3 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 6 3.3 O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1 10.1038/s41467-023-40064-9
25102847 78221 93 None -2 10 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2105717 78221 93 None -2 10 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 501 8 2 6 5.5 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC 10.1038/s41467-023-40064-9
1210 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
1213 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
2725 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
33036 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
4411 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
616 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
6976 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
716121 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1201353 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL1554789 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
CHEMBL505 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB01114 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
DB13679 918 51 None -524 22 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C 10.1038/s41467-023-40064-9
72095 78273 20 None - 1 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 246 6 2 3 1.8 C#CCOc1ccc(N)cc1C(=O)NCCCC 10.1038/s41467-023-40064-9
CHEMBL2107094 78273 20 None - 1 Human 4.5 pAC50 = 4.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 246 6 2 3 1.8 C#CCOc1ccc(N)cc1C(=O)NCCCC 10.1038/s41467-023-40064-9
3294 2006 111 None 2 23 Human 8.5 pAC50 = 8.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
71360 2006 111 None 2 23 Human 8.5 pAC50 = 8.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
87 2006 111 None 2 23 Human 8.5 pAC50 = 8.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
CHEMBL14376 2006 111 None 2 23 Human 8.5 pAC50 = 8.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
DB04946 2006 111 None 2 23 Human 8.5 pAC50 = 8.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
19675 51670 43 None -4 15 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 7 1 5 5.0 CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
CHEMBL1584 51670 43 None -4 15 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 410 7 1 5 5.0 CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2 10.1038/s41467-023-40064-9
2337 3256 77 None -7 29 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
50 3256 77 None -7 29 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
5002 3256 77 None -7 29 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL716 3256 77 None -7 29 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
DB01224 3256 77 None -7 29 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 10.1038/s41467-023-40064-9
24826799 10798 104 None 10 20 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 10798 104 None 10 20 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
19861 207523 50 None -10 10 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 290 0 0 2 3.7 CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1038/s41467-023-40064-9
CHEMBL946 207523 50 None -10 10 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 290 0 0 2 3.7 CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1038/s41467-023-40064-9
2274 3173 58 None -5 36 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
4917 3173 58 None -5 36 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
7279 3173 58 None -5 36 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
CHEMBL728 3173 58 None -5 36 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
DB00433 3173 58 None -5 36 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 10.1038/s41467-023-40064-9
1530 2182 50 None -5 25 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
3827 2182 50 None -5 25 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
7206 2182 50 None -5 25 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
CHEMBL534 2182 50 None -5 25 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
DB00920 2182 50 None -5 25 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 10.1038/s41467-023-40064-9
1816 2540 102 None -53 12 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
4205 2540 102 None -53 12 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
7241 2540 102 None -53 12 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
CHEMBL654 2540 102 None -53 12 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
DB00370 2540 102 None -53 12 Human 6.5 pAC50 = 6.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 10.1038/s41467-023-40064-9
1209 1658 75 None -3 20 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 1658 75 None -3 20 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 1658 75 None -3 20 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 1658 75 None -3 20 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 1658 75 None -3 20 Human 5.5 pAC50 = 5.5 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
5906 14495 23 None -3 4 Human 4.5 pAC50 = 4.5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
CHEMBL1201319 14495 23 None -3 4 Human 4.5 pAC50 = 4.5 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 167 2 3 3 0.8 C[C@H](N)[C@H](O)c1cccc(O)c1 10.1038/s41467-023-40064-9
22323 15299 32 None -2 11 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
9571037 15299 32 None -2 11 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1213553 15299 32 None -2 11 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 287 2 5 2 2.9 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1 10.1038/s41467-023-40064-9
1234 189221 56 None -13 10 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 484 14 0 7 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
CHEMBL1256940 189221 56 None -13 10 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 484 14 0 7 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
CHEMBL51149 189221 56 None -13 10 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 484 14 0 7 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC 10.1038/s41467-023-40064-9
2220 3134 82 None 6 17 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
27400 3134 82 None 6 17 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
93 3134 82 None 6 17 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
CHEMBL294951 3134 82 None 6 17 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
DB06153 3134 82 None 6 17 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 295 0 0 2 4.4 CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1 10.1038/s41467-023-40064-9
104850 3330 96 None -323 27 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3330 96 None -323 27 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3330 96 None -323 27 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3330 96 None -323 27 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3330 96 None -323 27 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4066 204626 78 None -239 16 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL73451 204626 78 None -239 16 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 322 2 0 3 4.6 c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2 10.1038/s41467-023-40064-9
2585 803 103 None -724 33 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 103 None -724 33 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 103 None -724 33 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 103 None -724 33 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 103 None -724 33 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
72093 35061 9 None -3 28 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35061 9 None -3 28 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35061 9 None -3 28 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
2105 3054 37 None -2 25 Human 8.3 pAC50 = 8.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
47811 3054 37 None -2 25 Human 8.3 pAC50 = 8.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
48 3054 37 None -2 25 Human 8.3 pAC50 = 8.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
CHEMBL531 3054 37 None -2 25 Human 8.3 pAC50 = 8.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
DB01186 3054 37 None -2 25 Human 8.3 pAC50 = 8.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 10.1038/s41467-023-40064-9
1043 1582 14 None -81 22 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
149 1582 14 None -81 22 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
8223 1582 14 None -81 22 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
CHEMBL442 1582 14 None -81 22 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
DB00696 1582 14 None -81 22 Human 7.4 pAC50 = 7.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1038/s41467-023-40064-9
4640 78266 30 None -3 11 Human 6.4 pAC50 = 6.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
CHEMBL2107011 78266 30 None -3 11 Human 6.4 pAC50 = 6.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 379 6 1 4 3.9 COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC 10.1038/s41467-023-40064-9
5453 203619 102 None -93 14 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 189 3 0 1 0.2 S=P(N1CC1)(N1CC1)N1CC1 10.1038/s41467-023-40064-9
CHEMBL671 203619 102 None -93 14 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 189 3 0 1 0.2 S=P(N1CC1)(N1CC1)N1CC1 10.1038/s41467-023-40064-9
2470 3653 50 None -2570 23 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
3300 3653 50 None -2570 23 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
5265 3653 50 None -2570 23 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
99 3653 50 None -2570 23 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL267930 3653 50 None -2570 23 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1038/s41467-023-40064-9
2795 14494 37 None 1 4 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 289 5 1 2 3.5 CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1201313 14494 37 None 1 4 Human 5.4 pAC50 = 5.4 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 289 5 1 2 3.5 CN(C)CCC(O)(c1ccccc1)c1ccccc1Cl 10.1038/s41467-023-40064-9
25382 9157 37 None -120 21 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
CHEMBL110094 9157 37 None -120 21 Human 5.4 pAC50 = 5.4 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 291 3 0 1 4.7 CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21 10.1038/s41467-023-40064-9
2407 3372 76 None -138 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
59227 3372 76 None -138 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
941 3372 76 None -138 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
CHEMBL1303 3372 76 None -138 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
DB05271 3372 76 None -138 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 315 6 1 3 4.3 CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 10.1038/s41467-023-40064-9
2267 559 71 None -190 14 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
271 559 71 None -190 14 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
7121 559 71 None -190 14 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL639 559 71 None -190 14 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00972 559 71 None -190 14 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 381 3 0 4 4.3 CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2 10.1038/s41467-023-40064-9
2435 3590 83 None -23 21 Human 6.3 pAC50 = 6.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
60149 3590 83 None -23 21 Human 6.3 pAC50 = 6.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
98 3590 83 None -23 21 Human 6.3 pAC50 = 6.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
CHEMBL12713 3590 83 None -23 21 Human 6.3 pAC50 = 6.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
DB06144 3590 83 None -23 21 Human 6.3 pAC50 = 6.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1038/s41467-023-40064-9
4150 788 39 None -72 15 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
5288 788 39 None -72 15 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
644019 788 39 None -72 15 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
CHEMBL190461 788 39 None -72 15 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
DB09061 788 39 None -72 15 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 314 6 2 2 5.8 CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C 10.1038/s41467-023-40064-9
5329102 194726 86 None -6 37 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194726 86 None -6 37 Human 5.3 pAC50 = 5.3 Functional
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
2601 3780 33 None -154 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
443951 3780 33 None -154 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
ChEMBL 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC 10.1038/s41467-023-40064-9
56 3780 33 None -154 17 Human 6.3 pAC50 = 6.3 Functional
Agonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human HTR2A in an