Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	46780481	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107531	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3151	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	216239	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23795	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	2176	49645	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1566249	49645	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	72106	78192	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78192	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	45138674	16646	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16646	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	439280	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	6971044	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL350221	120019	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	432824	78264	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78264	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	242	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	123606	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	5994	4641	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4641	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2335	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11848	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3149	12614	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12614	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	56959	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31556	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	4034	55822	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55822	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	71398	106439	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106439	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	180	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1890	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3316	31760	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31760	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	4993	122357	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122357	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	441074	19414	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19414	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	3658	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	191	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1613	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4640	78266	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78266	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	3158	56267	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56267	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	4011	82408	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82408	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2520	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	204008	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	5906	14495	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14495	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	72093	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4746	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204891	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	1012	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1013	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1057	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	5757	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	CHEMBL135	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	DB00783	25	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1224	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	202	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2419	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5077	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2855	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5029	15545	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	CHEMBL1219	15545	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	2162	41514	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41514	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	47510	172546	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172546	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	22323	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15299	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2895	203592	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203592	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205271	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2543	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	443955	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204370	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	5357	98736	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL277945	98736	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	16351	102730	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102730	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	57469	18866	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18866	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	2286	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2393	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	104850	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	96	None	-1230	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	24776445	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	4227	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	6975	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	CHEMBL473417	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	DB08828	3997	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	3081361	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93934	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2372	106468	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106468	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	71731823	111705	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111705	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	3074	17958	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL126075	17958	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL508338	188966	0	None	-218	15	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	2105	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11658860	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	124087	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2165	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203783	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3108	207287	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207287	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	1209	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	260	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2775	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	656665	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL56564	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB11699	3869	54	None	-4	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	4497	34404	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL1428	34404	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	3823	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50221	42	None	-38	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	10831	116963	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL338667	116963	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	3488	179136	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL472	179136	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	636403	188268	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188268	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	31703	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194717	63	None	-23	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2333	142335	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142335	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2169	44847	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44847	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5453	203619	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203619	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	19861	207523	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207523	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	137	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2541	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	587	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	6907	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1016	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB00796	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB13919	786	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	4942	5718	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5718	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	10102	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	2546	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	41684	31221	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31221	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4499	59775	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59775	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	37367	8651	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1095282	8651	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	11954369	189083	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	CHEMBL509924	189083	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	5991	203919	72	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	203919	72	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4760	204249	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL711	204249	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	4452	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	3294	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	214	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	37	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	57469	18866	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18866	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	46220502	112583	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112583	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	44112	121290	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121290	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2099	9307	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1110	9307	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	68867	78173	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78173	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	43815	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186920	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	60606	61560	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61560	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	5591	157531	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157531	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	108000	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56853	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	445643	97389	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	5639	98895	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98895	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	198	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	99	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	CHEMBL10878	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	DB06594	313	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	2726	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2473	163183	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	CHEMBL418134	163183	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	168871	89130	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	3752	27031	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	CHEMBL136497	27031	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	6010	30698	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	CHEMBL1395	30698	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	146570	43454	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43454	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1400	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	4150	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2865	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	4940	14470	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14470	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	2202	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	3689	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102771	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	4762	14469	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14469	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	445643	97389	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97389	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	53232	188625	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL503	188625	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	448537	160250	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160250	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	4756	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1201022	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1242	16649	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	27812	66991	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	66991	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	1153	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1628	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	150	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	31101	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	10007	14484	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201269	14484	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54841	203127	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	203127	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	1201549	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	68873	43564	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43564	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	319	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	4209	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL508338	188966	0	None	-218	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	8730	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	195891	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	4612	205980	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	CHEMBL847	205980	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	102	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	26987	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	21722	17992	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17992	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	4450	178228	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178228	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	100	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	124	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	47	None	-457	24	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2995	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204405	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2220	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	11626560	200937	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200937	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	213	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2402	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10531	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	21	None	-100	25	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2274	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	58	None	-35	36	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3926	207241	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207241	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25271887	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	5486971	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1059	5160	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	2351	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4300	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	50922675	112584	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	CHEMBL3301612	112584	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	154257	178619	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178619	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	6127	14499	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14499	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	5833	30484	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30484	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	4413	98073	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98073	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	5467	205928	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL84158	205928	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	5732	206935	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL911	206935	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	37	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	135	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	168871	89130	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89130	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	242	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	54477	84653	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	CHEMBL22242	84653	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	72093	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35061	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4066	204626	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204626	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2342	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	24826799	10798	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10798	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	5411	204033	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL698	204033	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	135409453	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	41	None	-28	35	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	1481	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	3749	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	589	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	6908	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1513	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	DB01029	2066	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	1343	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889

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Ligand source activities (1 row/activity)