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Ligand source activities (1 row/activity)

Ligand Receptor Assay information Chemical information
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GPCRdb ID #Vendors UniProt IUPHAR Species p-value
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Activity
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Assay Type Assay Description Source Mol
weight
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H don H acc LogP Smiles DOI
129456 200712 9 ACM2 M2 receptor Human 10.4 pEC50 = 10.4 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
CHEMBL92421 200712 9 ACM2 M2 receptor Human 10.4 pEC50 = 10.4 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
10104167 1928 0 Q8VH27 M2 receptor Guinea pig 10.1 pEC50 = 10.1 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
6937 1928 0 Q8VH27 M2 receptor Guinea pig 10.1 pEC50 = 10.1 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
CHEMBL3121473 1928 0 Q8VH27 M2 receptor Guinea pig 10.1 pEC50 = 10.1 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
10104167 1928 0 Q8VH27 M2 receptor Guinea pig 9.8 pEC50 = 9.8 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
6937 1928 0 Q8VH27 M2 receptor Guinea pig 9.8 pEC50 = 9.8 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
CHEMBL3121473 1928 0 Q8VH27 M2 receptor Guinea pig 9.8 pEC50 = 9.8 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1016/j.ejmech.2014.01.032
10104167 1928 0 ACM2 M2 receptor Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1021/acs.jmedchem.7b01113
6937 1928 0 ACM2 M2 receptor Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL3121473 1928 0 ACM2 M2 receptor Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 197 2 0 3 0.4 C[N+](CC#CCOC1=NOCC1)(C)C 10.1021/acs.jmedchem.7b01113
405242 11681 1 ACM2 M2 receptor Pig 9.3 pEC50 = 9.3 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
CHEMBL1182967 11681 1 ACM2 M2 receptor Pig 9.3 pEC50 = 9.3 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
CHEMBL274413 11681 1 ACM2 M2 receptor Pig 9.3 pEC50 = 9.3 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
23657685 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1195729 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1203986 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
23657685 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1195729 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1203986 13525 0 ACM2 M2 receptor Pig 9.1 pEC50 = 9.1 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 719 23 3 6 7.1 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1 10.1021/jm070859s
44435840 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1195736 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL555247 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
44435840 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1195736 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL555247 13526 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 897 30 3 7 9.0 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
11600184 12015 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 14 0 5 5.2 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1 10.1021/jm050769s
CHEMBL1184960 12015 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 14 0 5 5.2 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1 10.1021/jm050769s
CHEMBL380572 12015 0 ACM2 M2 receptor Pig 9.0 pEC50 = 9.0 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 14 0 5 5.2 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1 10.1021/jm050769s
23657683 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL1195234 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL1203985 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
23657683 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL1195234 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL1203985 13454 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 574 16 3 5 5.8 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 10.1021/jm070859s
44435838 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1190118 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1203984 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
44435838 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1190118 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
CHEMBL1203984 12774 0 ACM2 M2 receptor Pig 8.9 pEC50 = 8.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 863 30 3 7 8.3 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC 10.1021/jm070859s
23657687 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1190117 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL540132 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
23657687 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1190117 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL540132 12773 0 ACM2 M2 receptor Pig 8.8 pEC50 = 8.8 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 752 23 3 6 7.7 CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 10.1021/jm070859s
CHEMBL1223804 15719 0 ACM2 M2 receptor Human 7.0 pEC50 = 7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 370 4 0 3 4.1 CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
10653182 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm021077w
CHEMBL265482 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm021077w
CHEMBL281080 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm021077w
2370 592 25 Q8VH27 M2 receptor Guinea pig 6.0 pEC50 = 6 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
297 592 25 Q8VH27 M2 receptor Guinea pig 6.0 pEC50 = 6 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
358 592 25 Q8VH27 M2 receptor Guinea pig 6.0 pEC50 = 6 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
CHEMBL1482 592 25 Q8VH27 M2 receptor Guinea pig 6.0 pEC50 = 6 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
DB01019 592 25 Q8VH27 M2 receptor Guinea pig 6.0 pEC50 = 6 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
167962 3820 2 ACM2 M2 receptor Human 6.0 pEC50 = 6 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm020871e
362 3820 2 ACM2 M2 receptor Human 6.0 pEC50 = 6 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm020871e
CHEMBL31599 3820 2 ACM2 M2 receptor Human 6.0 pEC50 = 6 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm020871e
10653182 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm991136e
CHEMBL265482 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm991136e
CHEMBL281080 98439 0 ACM2 M2 receptor Pig 6.0 pEC50 = 6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 700 19 0 2 8.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1 10.1021/jm991136e
10437519 106200 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 389 12 0 2 3.4 CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL31475 106200 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 389 12 0 2 3.4 CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
137630848 160291 0 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 213 3 0 3 1.5 C[N+]1(C)CCC(OCc2nccs2)C1 10.1021/acs.jmedchem.7b01113
CHEMBL4061390 160291 0 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 213 3 0 3 1.5 C[N+]1(C)CCC(OCc2nccs2)C1 10.1021/acs.jmedchem.7b01113
CHEMBL4117131 160291 0 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 213 3 0 3 1.5 C[N+]1(C)CCC(OCc2nccs2)C1 10.1021/acs.jmedchem.7b01113
10386 160343 9 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 1 1 1.6 C[N+](C)(C)CCc1cccc(O)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4092348 160343 9 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 1 1 1.6 C[N+](C)(C)CCc1cccc(O)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4117554 160343 9 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 1 1 1.6 C[N+](C)(C)CCc1cccc(O)c1 10.1021/acs.jmedchem.7b01113
2230 445 46 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1016/s0960-894x(98)00509-5
296 445 46 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1016/s0960-894x(98)00509-5
CHEMBL7303 445 46 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1016/s0960-894x(98)00509-5
DB04365 445 46 ACM2 M2 receptor Human 5.0 pEC50 = 5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1016/s0960-894x(98)00509-5
76328902 105798 0 Q8VH27 M2 receptor Guinea pig 7.0 pEC50 = 7.0 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3121475 105798 0 Q8VH27 M2 receptor Guinea pig 7.0 pEC50 = 7.0 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3140248 105798 0 Q8VH27 M2 receptor Guinea pig 7.0 pEC50 = 7.0 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
2551 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.8b01967
298 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.8b01967
488 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.8b01967
CHEMBL965 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.8b01967
DB00411 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.8b01967
49799920 10262 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL1169506 10262 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
44408941 11529 0 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL1182020 11529 0 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL206666 11529 0 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
11120503 3949 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL100163 3949 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2 10.1016/s0960-894x(98)00509-5
137629935 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
118714969 120074 0 ACM2 M2 receptor Pig 8.0 pEC50 = 8.0 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 652 4 0 4 5.6 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1021/np500259j
CHEMBL3337859 120074 0 ACM2 M2 receptor Pig 8.0 pEC50 = 8.0 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 652 4 0 4 5.6 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1021/np500259j
CHEMBL3558417 120074 0 ACM2 M2 receptor Pig 8.0 pEC50 = 8.0 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 652 4 0 4 5.6 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1021/np500259j
44329977 110684 0 ACM2 M2 receptor Human 8.0 pEC50 = 8.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2 10.1016/s0960-894x(98)00509-5
CHEMBL327269 110684 0 ACM2 M2 receptor Human 8.0 pEC50 = 8.0 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.4 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2 10.1016/s0960-894x(98)00509-5
46878254 13940 0 ACM2 M2 receptor Human 8.0 pEC50 = 8.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/j.bmcl.2005.12.030
CHEMBL1199299 13940 0 ACM2 M2 receptor Human 8.0 pEC50 = 8.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/j.bmcl.2005.12.030
CHEMBL607178 13940 0 ACM2 M2 receptor Human 8.0 pEC50 = 8.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/j.bmcl.2005.12.030
60138187 105728 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 576 15 0 5 5.1 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
60138192 105728 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 576 15 0 5 5.1 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3121479 105728 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 576 15 0 5 5.1 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3139879 105728 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 576 15 0 5 5.1 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
44589681 183695 0 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
ChEMBL 387 5 2 6 1.5 NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1016/j.bmcl.2008.09.032
CHEMBL485913 183695 0 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
ChEMBL 387 5 2 6 1.5 NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1016/j.bmcl.2008.09.032
22745278 184386 1 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
ChEMBL 372 3 1 5 2.6 CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1016/j.bmcl.2008.09.023
CHEMBL491209 184386 1 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor
ChEMBL 372 3 1 5 2.6 CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1016/j.bmcl.2008.09.023
2551 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/jm00050a006
298 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/jm00050a006
488 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/jm00050a006
CHEMBL965 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/jm00050a006
DB00411 750 19 ACM2 M2 receptor Human 7.0 pEC50 = 7.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 147 3 1 2 -0.2 NC(=O)OCC[N+](C)(C)C 10.1021/jm00050a006
10104047 21249 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 192 3 1 4 0.9 C=CCn1ncc(C2CCCNC2)n1 10.1021/jm00050a006
CHEMBL131777 21249 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 192 3 1 4 0.9 C=CCn1ncc(C2CCCNC2)n1 10.1021/jm00050a006
CHEMBL4782416 181282 0 ACM2 M2 receptor Human 6.0 pEC50 = 6.0 ADMET
Positive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayPositive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay
ChEMBL 374 3 2 7 2.2 Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4cccnc4)C3)c(N)c12 10.1016/j.bmcl.2019.05.026
137629935 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Functional
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
135544402 112369 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5.0 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 444 9 1 4 4.0 O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
135597270 112369 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5.0 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 444 9 1 4 4.0 O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL1202147 112369 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5.0 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 444 9 1 4 4.0 O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL33142 112369 0 ACM2 M2 receptor Pig 5.0 pEC50 = 5.0 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 444 9 1 4 4.0 O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
11613432 12020 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL1184988 12020 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL382243 12020 0 ACM2 M2 receptor Human 5.0 pEC50 = 5.0 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
44265572 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL262448 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL27743 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
44265572 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL262448 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL27743 97977 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 616 15 0 4 5.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
10077281 103392 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL30939 103392 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL8653 103392 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL4796921 182412 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 ADMET
Positive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayPositive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay
ChEMBL 423 3 2 8 2.3 Cc1nnc2sc(C(=O)NC3CN(c4ncc(C(F)(F)F)cn4)C3)c(N)c2c1C 10.1016/j.bmcl.2019.05.026
122191002 122836 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 495 5 3 3 4.8 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F 10.1016/j.bmcl.2015.08.011
CHEMBL3618445 122836 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 495 5 3 3 4.8 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F 10.1016/j.bmcl.2015.08.011
44318743 105231 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 584 0 0 6 4.3 C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43 10.1016/s0960-894x(00)00509-6
CHEMBL312920 105231 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 584 0 0 6 4.3 C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43 10.1016/s0960-894x(00)00509-6
118714976 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337863 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558421 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
76328902 105798 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3121475 105798 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3140248 105798 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 512 14 0 5 3.5 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
118714976 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337863 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558421 120076 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 654 7 1 3 6.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
187 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
294 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
65 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
8593 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL667 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
DB03128 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
11828809 11672 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 618 15 0 4 5.7 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL1182934 11672 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 618 15 0 4 5.7 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL273255 11672 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 618 15 0 4 5.7 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
134207697 173433 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR
ChEMBL 428 3 2 7 3.0 Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1 10.1016/j.bmcl.2019.06.032
CHEMBL4549515 173433 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 Binding
Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR
ChEMBL 428 3 2 7 3.0 Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1 10.1016/j.bmcl.2019.06.032
170332 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4091934 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4115997 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
10438106 98953 0 ACM2 M2 receptor Pig 4.9 pEC50 = 4.9 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 415 8 0 2 4.5 Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL1202149 98953 0 ACM2 M2 receptor Pig 4.9 pEC50 = 4.9 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 415 8 0 2 4.5 Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL284370 98953 0 ACM2 M2 receptor Pig 4.9 pEC50 = 4.9 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 415 8 0 2 4.5 Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
3652 3848 63 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1016/j.bmcl.2015.08.011
57 3848 63 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1016/j.bmcl.2015.08.011
60809 3848 63 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1016/j.bmcl.2015.08.011
CHEMBL21536 3848 63 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1016/j.bmcl.2015.08.011
DB15357 3848 63 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1016/j.bmcl.2015.08.011
44303017 194418 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 343 3 0 5 2.4 Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1 10.1021/jm9910019
CHEMBL60101 194418 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 343 3 0 5 2.4 Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1 10.1021/jm9910019
44279262 105355 0 ACM2 M2 receptor Pig 4.9 pEC50 = 4.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 522 16 0 4 3.2 C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C 10.1021/jm021077w
CHEMBL31336 105355 0 ACM2 M2 receptor Pig 4.9 pEC50 = 4.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 522 16 0 4 3.2 C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C 10.1021/jm021077w
10795567 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm021077w
CHEMBL285598 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm021077w
CHEMBL303052 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm021077w
CHEMBL1223806 15721 0 ACM2 M2 receptor Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 358 3 0 5 3.9 CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
10795567 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm991136e
CHEMBL285598 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm991136e
CHEMBL303052 99132 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 668 19 0 4 8.1 CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C 10.1021/jm991136e
187 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
294 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
65 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
8593 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL667 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
DB03128 245 23 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
167962 3820 2 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm050769s
362 3820 2 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm050769s
CHEMBL31599 3820 2 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm050769s
405252 11648 1 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
CHEMBL1182747 11648 1 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
CHEMBL263972 11648 1 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
1273 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
3450 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
356 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
6172 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
67425 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
CHEMBL360055 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
DB00483 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
45786849 156987 20 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 192 3 1 3 1.4 c1cncc(COC2CCCNC2)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4083241 156987 20 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 192 3 1 3 1.4 c1cncc(COC2CCCNC2)c1 10.1021/acs.jmedchem.7b01113
1273 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
3450 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
356 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
6172 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
67425 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
CHEMBL360055 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
DB00483 1635 10 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 510 21 0 3 5.5 CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC 10.1021/jm070859s
10865495 17700 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
CHEMBL126655 17700 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
CHEMBL8898 17700 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
10865495 17700 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL126655 17700 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL8898 17700 0 ACM2 M2 receptor Pig 6.9 pEC50 = 6.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
167962 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021017q
362 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021017q
CHEMBL31599 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021017q
10699850 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL168760 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL286892 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
44330073 201957 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 327 3 0 5 3.1 C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL99884 201957 0 ACM2 M2 receptor Human 6.9 pEC50 = 6.9 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 327 3 0 5 3.1 C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2 10.1016/s0960-894x(98)00509-5
10699850 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL168760 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL286892 99325 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 534 14 0 4 3.7 C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
44209166 59021 0 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)
ChEMBL 193 1 0 4 1.0 Cc1noc(C2(C)CN3CCC2C3)n1 10.1021/jm00083a016
CHEMBL171721 59021 0 ACM2 M2 receptor Human 7.9 pEC50 = 7.9 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)
ChEMBL 193 1 0 4 1.0 Cc1noc(C2(C)CN3CCC2C3)n1 10.1021/jm00083a016
60138189 105800 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 526 15 0 5 3.9 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
60138190 105800 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 526 15 0 5 3.9 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3121476 105800 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 526 15 0 5 3.9 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3140252 105800 0 Q8VH27 M2 receptor Guinea pig 7.9 pEC50 = 7.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 526 15 0 5 3.9 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1016/j.ejmech.2014.01.032
11007357 10801 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 668 15 0 4 6.8 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL1177962 10801 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 668 15 0 4 6.8 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL8721 10801 0 ACM2 M2 receptor Pig 7.9 pEC50 = 7.9 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 668 15 0 4 6.8 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
10795468 11451 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 646 15 0 8 3.7 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL1181455 11451 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 646 15 0 8 3.7 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL171664 11451 0 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 646 15 0 8 3.7 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
170332 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4091934 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4115997 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
2370 592 25 Q8VH27 M2 receptor Guinea pig 5.9 pEC50 = 5.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
297 592 25 Q8VH27 M2 receptor Guinea pig 5.9 pEC50 = 5.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
358 592 25 Q8VH27 M2 receptor Guinea pig 5.9 pEC50 = 5.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
CHEMBL1482 592 25 Q8VH27 M2 receptor Guinea pig 5.9 pEC50 = 5.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
DB01019 592 25 Q8VH27 M2 receptor Guinea pig 5.9 pEC50 = 5.9 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 161 3 1 2 0.2 CC(C[N+](C)(C)C)OC(=O)N 10.1016/j.ejmech.2014.01.032
167962 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm991136e
362 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm991136e
CHEMBL31599 3820 2 ACM2 M2 receptor Pig 5.9 pEC50 = 5.9 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm991136e
170332 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4091934 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4115997 160151 1 ACM2 M2 receptor Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 194 4 0 1 1.9 COc1cccc(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
167962 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
362 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
CHEMBL31599 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
405254 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL269205 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL31380 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
167962 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
362 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
CHEMBL31599 3820 2 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 548 15 0 4 4.1 O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
405254 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL269205 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL31380 105461 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 598 15 0 4 5.2 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
44303408 195531 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 361 3 0 5 2.6 Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
CHEMBL60777 195531 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 361 3 0 5 2.6 Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
44319261 12057 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 866 4 0 4 10.0 C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34 10.1016/s0960-894x(00)00509-6
CHEMBL1185324 12057 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 866 4 0 4 10.0 C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34 10.1016/s0960-894x(00)00509-6
CHEMBL407440 12057 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 866 4 0 4 10.0 C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34 10.1016/s0960-894x(00)00509-6
10629136 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm021077w
CHEMBL30376 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm021077w
CHEMBL68151 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm021077w
10629136 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm991136e
CHEMBL30376 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm991136e
CHEMBL68151 101642 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 636 19 0 4 6.6 CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C 10.1021/jm991136e
10985389 11688 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 550 15 0 6 2.9 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL1183013 11688 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 550 15 0 6 2.9 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL275988 11688 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 550 15 0 6 2.9 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
10451242 196694 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 361 3 0 5 2.8 Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
CHEMBL64029 196694 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 361 3 0 5 2.8 Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
44408892 74565 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 372 4 0 4 4.1 CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL203627 74565 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 372 4 0 4 4.1 CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
44265578 17593 1 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
CHEMBL126103 17593 1 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
CHEMBL268194 17593 1 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
44265578 17593 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL126103 17593 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL268194 17593 1 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 576 15 0 4 4.7 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
137629935 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
10257778 116038 0 ACM2 M2 receptor Pig 4.8 pEC50 = 4.8 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 426 8 0 3 4.1 N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL1202150 116038 0 ACM2 M2 receptor Pig 4.8 pEC50 = 4.8 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 426 8 0 3 4.1 N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL33774 116038 0 ACM2 M2 receptor Pig 4.8 pEC50 = 4.8 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 426 8 0 3 4.1 N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1 10.1021/jm00036a008
CHEMBL3616500 122560 0 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 499 5 2 3 5.4 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2015.08.011
137629935 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
44318815 12063 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 902 4 0 4 9.7 FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
CHEMBL1185416 12063 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 902 4 0 4 9.7 FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
CHEMBL412670 12063 0 ACM2 M2 receptor Pig 5.8 pEC50 = 5.8 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 902 4 0 4 9.7 FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
10974720 17616 0 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
CHEMBL126199 17616 0 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
CHEMBL9071 17616 0 ACM2 M2 receptor Human 6.8 pEC50 = 6.8 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm020871e
10974720 17616 0 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL126199 17616 0 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL9071 17616 0 ACM2 M2 receptor Pig 6.8 pEC50 = 6.8 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
89777356 155073 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 353 3 2 6 2.5 Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
CHEMBL4060475 155073 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 353 3 2 6 2.5 Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
76325356 105792 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 562 14 0 5 4.7 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3120178 105792 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 562 14 0 5 4.7 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3140233 105792 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 562 14 0 5 4.7 C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
405246 11683 1 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 654 15 0 4 6.5 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
CHEMBL1182976 11683 1 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 654 15 0 4 6.5 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
CHEMBL274564 11683 1 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 654 15 0 4 6.5 CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O 10.1021/jm021017q
53385782 73729 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay
ChEMBL 399 4 1 4 3.3 CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2 10.1016/j.bmcl.2012.03.088
CHEMBL2024331 73729 0 ACM2 M2 receptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay
ChEMBL 399 4 1 4 3.3 CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2 10.1016/j.bmcl.2012.03.088
424727 160349 2 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 0 1 1.9 COc1ccccc1C[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL4095774 160349 2 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 0 1 1.9 COc1ccccc1C[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL4117601 160349 2 ACM2 M2 receptor Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 180 3 0 1 1.9 COc1ccccc1C[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
302 2796 20 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 206 2 0 2 0.7 O=C1CCCN1CC#CCN1CCCC1 10.1021/jm00012a019
4630 2796 20 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 206 2 0 2 0.7 O=C1CCCN1CC#CCN1CCCC1 10.1021/jm00012a019
CHEMBL7634 2796 20 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 206 2 0 2 0.7 O=C1CCCN1CC#CCN1CCCC1 10.1021/jm00012a019
129456 200712 9 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
CHEMBL92421 200712 9 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
CHEMBL1223754 15696 0 ACM2 M2 receptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 403 5 1 4 4.5 CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
187 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
294 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
65 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
8593 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL667 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
DB03128 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
10676698 11450 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 618 13 0 8 3.0 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL1181450 11450 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 618 13 0 8 3.0 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL171388 11450 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 618 13 0 8 3.0 O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
9820835 116030 2 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 179 2 1 5 0.1 CCn1nnc(C2=CCCNC2)n1 10.1021/jm00050a006
CHEMBL337676 116030 2 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 179 2 1 5 0.1 CCn1nnc(C2=CCCNC2)n1 10.1021/jm00050a006
187 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
294 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
65 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
8593 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
CHEMBL667 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
DB03128 245 23 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/acs.jmedchem.7b01113
10604576 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm021077w
CHEMBL303002 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm021077w
CHEMBL31162 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm021077w
10604576 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm991136e
CHEMBL303002 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm991136e
CHEMBL31162 104611 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 520 15 0 2 4.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O 10.1021/jm991136e
21158560 112057 3 ACM2 M2 receptor Pig 8.7 pEC50 = 8.7 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 666 6 2 4 5.5 C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3305985 112057 3 ACM2 M2 receptor Pig 8.7 pEC50 = 8.7 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 666 6 2 4 5.5 C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69 10.1021/np500259j
9927975 3943 0 ACM2 M2 receptor Human 8.7 pEC50 = 8.7 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 341 3 0 5 3.5 C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL100147 3943 0 ACM2 M2 receptor Human 8.7 pEC50 = 8.7 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 341 3 0 5 3.5 C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2 10.1016/s0960-894x(98)00509-5
11527805 12019 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 576 13 0 4 4.3 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O 10.1021/jm050769s
CHEMBL1184985 12019 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 576 13 0 4 4.3 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O 10.1021/jm050769s
CHEMBL381913 12019 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 576 13 0 4 4.3 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O 10.1021/jm050769s
11535022 11521 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 13 0 3 4.8 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O 10.1021/jm050769s
CHEMBL1181943 11521 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 13 0 3 4.8 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O 10.1021/jm050769s
CHEMBL199636 11521 0 ACM2 M2 receptor Pig 8.6 pEC50 = 8.6 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 574 13 0 3 4.8 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O 10.1021/jm050769s
60138188 105730 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 548 13 0 5 4.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
60138191 105730 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 548 13 0 5 4.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3121478 105730 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 548 13 0 5 4.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
CHEMBL3139897 105730 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response
ChEMBL 548 13 0 5 4.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O 10.1016/j.ejmech.2014.01.032
44265574 10803 0 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 676 15 0 4 5.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL1177964 10803 0 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 676 15 0 4 5.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL8764 10803 0 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 676 15 0 4 5.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
405250 11553 1 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O 10.1021/jm021017q
CHEMBL1182178 11553 1 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O 10.1021/jm021017q
CHEMBL216974 11553 1 ACM2 M2 receptor Pig 6.7 pEC50 = 6.7 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 648 15 0 4 6.4 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O 10.1021/jm021017q
76328904 105731 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 560 10 0 5 4.4 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.ejmech.2014.01.032
CHEMBL3121480 105731 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 560 10 0 5 4.4 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.ejmech.2014.01.032
CHEMBL3139898 105731 0 Q8VH27 M2 receptor Guinea pig 7.7 pEC50 = 7.7 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 560 10 0 5 4.4 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1 10.1016/j.ejmech.2014.01.032
11585610 12021 0 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 522 13 0 3 3.5 C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
CHEMBL1184995 12021 0 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 522 13 0 3 3.5 C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
CHEMBL382659 12021 0 ACM2 M2 receptor Pig 7.7 pEC50 = 7.7 Binding
Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2
ChEMBL 522 13 0 3 3.5 C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm050769s
145973726 163806 0 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response
ChEMBL 356 2 1 5 3.3 Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.10.053
CHEMBL4216213 163806 0 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response
ChEMBL 356 2 1 5 3.3 Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.10.053
137629935 160195 0 ACM2 M2 receptor Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
11757557 99410 0 ACM2 M2 receptor Pig 4.7 pEC50 = 4.7 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 401 8 0 2 4.2 Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1 10.1021/jm00036a008
CHEMBL1202151 99410 0 ACM2 M2 receptor Pig 4.7 pEC50 = 4.7 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 401 8 0 2 4.2 Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1 10.1021/jm00036a008
CHEMBL287536 99410 0 ACM2 M2 receptor Pig 4.7 pEC50 = 4.7 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 401 8 0 2 4.2 Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1 10.1021/jm00036a008
122191003 122837 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 509 6 3 3 4.9 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1 10.1016/j.bmcl.2015.08.011
CHEMBL3618446 122837 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 509 6 3 3 4.9 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1 10.1016/j.bmcl.2015.08.011
44279470 101616 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 570 16 0 4 3.8 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O 10.1021/jm021077w
CHEMBL30361 101616 0 ACM2 M2 receptor Pig 5.7 pEC50 = 5.7 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 570 16 0 4 3.8 C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O 10.1021/jm021077w
137635723 155274 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 411 3 2 9 2.5 Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
CHEMBL4062934 155274 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 411 3 2 9 2.5 Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
187 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
294 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
65 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
8593 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
CHEMBL667 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
DB03128 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1016/j.bmcl.2012.05.048
187 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
294 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
65 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
8593 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
CHEMBL667 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
DB03128 245 23 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
ChEMBL 146 3 0 2 0.3 CC(=O)OCC[N+](C)(C)C 10.1021/jm100697g
137630667 160267 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 204 3 0 1 2.7 C[N+](C)(C)CCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
CHEMBL4100938 160267 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 204 3 0 1 2.7 C[N+](C)(C)CCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
CHEMBL4116890 160267 0 ACM2 M2 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 204 3 0 1 2.7 C[N+](C)(C)CCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
57230548 172388 0 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL4524085 172388 0 ACM2 M2 receptor Human 5.7 pEC50 = 5.7 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
44330080 106995 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL319109 106995 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2 10.1016/s0960-894x(98)00509-5
44303018 195608 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 343 3 0 5 2.4 Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
CHEMBL60833 195608 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 343 3 0 5 2.4 Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
11094083 10804 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 684 15 0 4 6.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O 10.1021/jm021017q
CHEMBL1177968 10804 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 684 15 0 4 6.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O 10.1021/jm021017q
CHEMBL8855 10804 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 684 15 0 4 6.7 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O 10.1021/jm021017q
11613432 12020 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL1184988 12020 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL382243 12020 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer
ChEMBL 402 4 0 2 4.4 C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
10747747 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm021077w
CHEMBL280535 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm021077w
CHEMBL304129 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm021077w
10747747 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm991136e
CHEMBL280535 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm991136e
CHEMBL304129 98377 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors
ChEMBL 608 19 0 4 5.9 CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC 10.1021/jm991136e
44408941 11529 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL1182020 11529 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
CHEMBL206666 11529 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Binding
Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
ChEMBL 454 8 0 2 5.5 C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2 10.1016/j.bmcl.2005.12.030
137631026 160325 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 230 1 0 1 3.0 C[N+](C)(C)C1CCc2ccc3ccoc3c2C1 10.1021/acs.jmedchem.7b01113
CHEMBL4093215 160325 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 230 1 0 1 3.0 C[N+](C)(C)C1CCc2ccc3ccoc3c2C1 10.1021/acs.jmedchem.7b01113
CHEMBL4117321 160325 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 230 1 0 1 3.0 C[N+](C)(C)C1CCc2ccc3ccoc3c2C1 10.1021/acs.jmedchem.7b01113
137628799 160168 0 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 212 4 0 1 2.1 COc1ccc(F)c(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4064668 160168 0 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 212 4 0 1 2.1 COc1ccc(F)c(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4116150 160168 0 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 212 4 0 1 2.1 COc1ccc(F)c(CC[N+](C)(C)C)c1 10.1021/acs.jmedchem.7b01113
10483419 110620 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 423 11 0 2 5.1 CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL32689 110620 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 423 11 0 2 5.1 CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL539621 110620 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 423 11 0 2 5.1 CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
10771150 11452 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 560 11 0 4 3.4 O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL1181457 11452 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 560 11 0 4 3.4 O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL171776 11452 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 560 11 0 4 3.4 O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
44278967 99067 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 549 15 0 5 3.5 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL285136 99067 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 549 15 0 5 3.5 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
137629935 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
44279153 106290 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 333 10 1 3 2.3 C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL31533 106290 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 333 10 1 3 2.3 C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL3616504 122562 0 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 441 3 2 3 4.0 CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2 10.1016/j.bmcl.2015.08.011
137629935 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
10686494 99833 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.7 CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1 10.1016/s0960-894x(98)00509-5
CHEMBL291351 99833 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 311 3 0 5 2.7 CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1 10.1016/s0960-894x(98)00509-5
10686494 99833 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 311 3 0 5 2.7 CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1 10.1021/jm9910019
CHEMBL291351 99833 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 311 3 0 5 2.7 CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1 10.1021/jm9910019
CHEMBL3618449 122840 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 449 5 2 3 4.5 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2015.08.011
2230 445 46 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1021/jm00012a019
296 445 46 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1021/jm00012a019
CHEMBL7303 445 46 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1021/jm00012a019
DB04365 445 46 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 155 1 0 3 0.4 COC(=O)C1=CCCN(C1)C 10.1021/jm00012a019
9987754 10797 0 ACM2 M2 receptor Pig 7.6 pEC50 = 7.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 612 15 0 4 5.5 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL1177947 10797 0 ACM2 M2 receptor Pig 7.6 pEC50 = 7.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 612 15 0 4 5.5 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL8449 10797 0 ACM2 M2 receptor Pig 7.6 pEC50 = 7.6 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 612 15 0 4 5.5 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
155524827 170078 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 ADMET
Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assayAgonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay
ChEMBL 367 4 0 6 3.1 COc1cccnc1C1CCN(C2CCCN(c3cnccn3)CC2)CC1 10.1021/acsmedchemlett.9b00106
CHEMBL4455058 170078 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 ADMET
Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assayAgonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay
ChEMBL 367 4 0 6 3.1 COc1cccnc1C1CCN(C2CCCN(c3cnccn3)CC2)CC1 10.1021/acsmedchemlett.9b00106
10007510 108968 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 381 8 0 2 3.9 C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL1202152 108968 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 381 8 0 2 3.9 C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL32278 108968 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 381 8 0 2 3.9 C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL1223863 15746 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 383 4 0 6 3.8 CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
CHEMBL1223864 15747 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 436 5 0 7 3.4 CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
CHEMBL1223941 15767 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 413 6 0 7 3.5 COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
78319052 170502 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 ADMET
Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assayAgonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay
ChEMBL 361 4 0 5 3.3 CCOC(=O)N1CCCC(N2CCC(c3ncccc3OC)CC2)CC1 10.1021/acsmedchemlett.9b00106
CHEMBL4461438 170502 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 ADMET
Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assayAgonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay
ChEMBL 361 4 0 5 3.3 CCOC(=O)N1CCCC(N2CCC(c3ncccc3OC)CC2)CC1 10.1021/acsmedchemlett.9b00106
118714979 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337866 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558422 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
10319023 110617 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 323 6 0 2 4.2 CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
CHEMBL32688 110617 0 ACM2 M2 receptor Pig 4.6 pEC50 = 4.6 Binding
Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart
ChEMBL 323 6 0 2 4.2 CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1 10.1021/jm00036a008
118714979 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337866 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558422 120077 0 ACM2 M2 receptor Pig 6.6 pEC50 = 6.6 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 586 2 0 2 6.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
89777060 156307 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 397 3 2 7 2.5 Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
CHEMBL4074908 156307 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
ChEMBL 397 3 2 7 2.5 Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C 10.1016/j.bmcl.2017.05.014
5487543 199203 1 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 270 3 0 4 1.8 COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1 10.1021/jm9910019
CHEMBL81878 199203 1 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 270 3 0 4 1.8 COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1 10.1021/jm9910019
10770828 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL165814 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL31895 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
11725107 99908 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 345 3 0 5 2.1 Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
CHEMBL291872 99908 0 ACM2 M2 receptor Human 5.6 pEC50 = 5.6 Functional
Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor
ChEMBL 345 3 0 5 2.1 Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 10.1021/jm9910019
10770828 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL165814 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL31895 106866 0 ACM2 M2 receptor Pig 5.6 pEC50 = 5.6 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 520 13 0 4 3.3 C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
137629887 160185 0 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 218 4 0 1 3.1 C[N+](C)(C)CCCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
CHEMBL4065555 160185 0 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 218 4 0 1 3.1 C[N+](C)(C)CCCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
CHEMBL4116259 160185 0 ACM2 M2 receptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 218 4 0 1 3.1 C[N+](C)(C)CCCc1ccc2ccoc2c1 10.1021/acs.jmedchem.7b01113
10375002 23753 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 178 2 1 4 0.7 CCn1ncc(C2=CCCNC2)n1 10.1021/jm00050a006
CHEMBL133905 23753 0 ACM2 M2 receptor Human 6.6 pEC50 = 6.6 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 178 2 1 4 0.7 CCn1ncc(C2=CCCNC2)n1 10.1021/jm00050a006
44158142 185836 28 ACM2 M2 receptor Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization
ChEMBL 339 2 0 2 4.1 O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21 10.1016/j.bmcl.2009.11.089
CHEMBL503735 185836 28 ACM2 M2 receptor Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization
ChEMBL 339 2 0 2 4.1 O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21 10.1016/j.bmcl.2009.11.089
5487543 199203 1 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 270 3 0 4 1.8 COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1 10.1016/s0960-894x(98)00509-5
CHEMBL81878 199203 1 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 270 3 0 4 1.8 COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1 10.1016/s0960-894x(98)00509-5
650899 53914 9 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]
ChEMBL 319 6 2 4 1.6 CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1 nan
CHEMBL1535797 53914 9 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]
ChEMBL 319 6 2 4 1.6 CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1 nan
CHEMBL1609153 53914 9 ACM2 M2 receptor Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]
ChEMBL 319 6 2 4 1.6 CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1 nan
44158142 185836 28 ACM2 M2 receptor Rat 5.6 pEC50 = 5.6 Functional
Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
ChEMBL 339 2 0 2 4.1 O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21 10.1021/jm900286j
CHEMBL503735 185836 28 ACM2 M2 receptor Rat 5.6 pEC50 = 5.6 Functional
Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization
ChEMBL 339 2 0 2 4.1 O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21 10.1021/jm900286j
57088082 172389 0 ACM2 M2 receptor Human 7.5 pEC50 = 7.5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
CHEMBL4524086 172389 0 ACM2 M2 receptor Human 7.5 pEC50 = 7.5 Functional
Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor
ChEMBL 325 3 0 5 2.8 C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2 10.1016/s0960-894x(98)00509-5
53414666 158476 7 ACM2 M2 receptor Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 192 4 1 3 1.2 c1cncc(COCC2CCNC2)c1 10.1021/acs.jmedchem.7b01113
CHEMBL4099673 158476 7 ACM2 M2 receptor Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method
ChEMBL 192 4 1 3 1.2 c1cncc(COCC2CCNC2)c1 10.1021/acs.jmedchem.7b01113
178030 20983 21 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 193 2 0 5 0.4 CCn1nnc(C2=CCCN(C)C2)n1 10.1016/j.bmcl.2015.08.011
CHEMBL131428 20983 21 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 193 2 0 5 0.4 CCn1nnc(C2=CCCN(C)C2)n1 10.1016/j.bmcl.2015.08.011
154734599 2351 5 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 582 29 4 6 7.2 COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC 10.1021/jm021077w
327 2351 5 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 582 29 4 6 7.2 COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC 10.1021/jm021077w
4108 2351 5 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 582 29 4 6 7.2 COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC 10.1021/jm021077w
CHEMBL27673 2351 5 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 582 29 4 6 7.2 COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC 10.1021/jm021077w
44319052 11784 0 ACM2 M2 receptor Pig 8.5 pEC50 = 8.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL1183674 11784 0 ACM2 M2 receptor Pig 8.5 pEC50 = 8.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL311649 11784 0 ACM2 M2 receptor Pig 8.5 pEC50 = 8.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 666 4 0 4 5.7 C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
129456 200712 9 ACM2 M2 receptor Human 8.5 pEC50 = 8.5 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
CHEMBL92421 200712 9 ACM2 M2 receptor Human 8.5 pEC50 = 8.5 Functional
In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)
ChEMBL 179 1 0 4 0.8 Cc1noc(C2CN3CCC2C3)n1 10.1021/jm00083a016
44319054 11788 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 670 4 0 4 6.1 CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL1183713 11788 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 670 4 0 4 6.1 CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL314491 11788 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 670 4 0 4 6.1 CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
11115491 11639 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 660 15 0 4 6.7 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL1182715 11639 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 660 15 0 4 6.7 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL262449 11639 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 660 15 0 4 6.7 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O 10.1021/jm021017q
44265538 10805 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.4 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL1177969 10805 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.4 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL8900 10805 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.4 CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
2520 197581 55 ACM2 M2 receptor Pig 4.5 pEC50 = 4.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1021/jm021077w
CHEMBL1280 197581 55 ACM2 M2 receptor Pig 4.5 pEC50 = 4.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1021/jm021077w
CHEMBL6966 197581 55 ACM2 M2 receptor Pig 4.5 pEC50 = 4.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC 10.1021/jm021077w
118720626 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3355097 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558555 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
44318760 12053 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 856 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
CHEMBL1185295 12053 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 856 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
CHEMBL405691 12053 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 856 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1016/s0960-894x(00)00509-6
44279242 104865 0 ACM2 M2 receptor Pig 4.5 pEC50 = 4.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 494 16 0 4 2.7 CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O 10.1021/jm021077w
CHEMBL31221 104865 0 ACM2 M2 receptor Pig 4.5 pEC50 = 4.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 494 16 0 4 2.7 CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O 10.1021/jm021077w
118720626 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3355097 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558555 120082 0 ACM2 M2 receptor Pig 7.5 pEC50 = 7.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 844 9 1 7 8.5 CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
118714974 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337862 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558420 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
44265563 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021077w
CHEMBL285811 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021077w
CHEMBL8491 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021077w
44265563 99156 0 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm020871e
CHEMBL285811 99156 0 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm020871e
CHEMBL8491 99156 0 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm020871e
118714974 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337862 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558420 120075 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 602 3 1 3 5.6 CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69 10.1021/np500259j
44265563 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL285811 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
CHEMBL8491 99156 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 562 15 0 4 4.4 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O 10.1021/jm021017q
137629935 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
137629935 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4060823 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
CHEMBL4116342 160195 0 ACM2 M2 receptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method
ChEMBL 206 3 0 1 1.9 C[N+](C)(C)CCc1ccc2c(c1)OCC2 10.1021/acs.jmedchem.7b01113
118714971 120070 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 842 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1021/np500259j
CHEMBL3337860 120070 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 842 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1021/np500259j
CHEMBL3558367 120070 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 842 6 0 8 7.5 O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1 10.1021/np500259j
CHEMBL3618448 122839 0 ACM2 M2 receptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
ChEMBL 523 6 2 3 5.2 C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1 10.1016/j.bmcl.2015.08.011
44319263 12066 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 886 8 0 8 7.7 COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC 10.1016/s0960-894x(00)00509-6
CHEMBL1185419 12066 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 886 8 0 8 7.7 COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC 10.1016/s0960-894x(00)00509-6
CHEMBL412718 12066 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 886 8 0 8 7.7 COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC 10.1016/s0960-894x(00)00509-6
10556700 11952 0 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 546 10 0 4 3.0 O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL1184494 11952 0 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 546 10 0 4 3.0 O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL352356 11952 0 ACM2 M2 receptor Pig 5.5 pEC50 = 5.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 546 10 0 4 3.0 O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
10843180 11448 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 674 17 0 8 3.8 O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL1181400 11448 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 674 17 0 8 3.8 O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
CHEMBL169638 11448 0 ACM2 M2 receptor Pig 6.5 pEC50 = 6.5 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 674 17 0 8 3.8 O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1 10.1021/jm981023f
118714981 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337867 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558423 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
11828771 16373 0 ACM2 M2 receptor Human 7.4 pEC50 = 7.4 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
CHEMBL124330 16373 0 ACM2 M2 receptor Human 7.4 pEC50 = 7.4 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
CHEMBL8729 16373 0 ACM2 M2 receptor Human 7.4 pEC50 = 7.4 Binding
Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm020871e
118714981 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3337867 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
CHEMBL3558423 120078 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 638 6 0 2 7.7 C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69 10.1021/np500259j
11115442 12054 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 640 15 0 4 6.2 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL1185309 12054 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 640 15 0 4 6.2 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
CHEMBL406431 12054 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 640 15 0 4 6.2 Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O 10.1021/jm021017q
11828771 16373 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL124330 16373 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
CHEMBL8729 16373 0 ACM2 M2 receptor Pig 7.4 pEC50 = 7.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 604 15 0 4 5.3 Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O 10.1021/jm021017q
168057 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
7634 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
CHEMBL28407 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm981023f
44318758 12029 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 960 8 0 8 6.7 O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL1185047 12029 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 960 8 0 8 6.7 O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL385915 12029 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 960 8 0 8 6.7 O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
76321739 105729 0 Q8VH27 M2 receptor Guinea pig 7.4 pEC50 = 7.4 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 510 10 0 5 3.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1 10.1016/j.ejmech.2014.01.032
CHEMBL3121477 105729 0 Q8VH27 M2 receptor Guinea pig 7.4 pEC50 = 7.4 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 510 10 0 5 3.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1 10.1016/j.ejmech.2014.01.032
CHEMBL3139896 105729 0 Q8VH27 M2 receptor Guinea pig 7.4 pEC50 = 7.4 Binding
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response
ChEMBL 510 10 0 5 3.3 C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1 10.1016/j.ejmech.2014.01.032
10699593 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL282782 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
CHEMBL353262 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm981023f
10699593 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL282782 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL353262 98711 0 ACM2 M2 receptor Pig 5.4 pEC50 = 5.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 506 12 0 4 2.9 C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
168057 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
7634 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
CHEMBL28407 1137 6 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 562 16 0 4 4.5 O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2 10.1021/jm021077w
3652 3848 63 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1021/jm9910019
57 3848 63 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1021/jm9910019
60809 3848 63 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1021/jm9910019
CHEMBL21536 3848 63 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1021/jm9910019
DB15357 3848 63 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells
ChEMBL 281 7 0 5 3.2 CCCCCCOc1nsnc1C1=CCCN(C1)C 10.1021/jm9910019
44279691 99038 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 664 15 0 4 5.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL284962 99038 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
ChEMBL 664 15 0 4 5.8 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021077w
CHEMBL1223862 15745 0 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay
ChEMBL 388 5 0 6 4.0 CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1 10.1016/j.bmcl.2010.07.097
10909212 12083 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 804 15 0 4 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O 10.1021/jm021017q
CHEMBL1185516 12083 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 804 15 0 4 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O 10.1021/jm021017q
CHEMBL418702 12083 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 804 15 0 4 7.3 C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O 10.1021/jm021017q
44319178 12119 0 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 662 2 0 4 4.6 C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL1185797 12119 0 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 662 2 0 4 4.6 C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
CHEMBL433343 12119 0 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2
ChEMBL 662 2 0 4 4.6 C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2 10.1016/s0960-894x(00)00509-6
405242 11681 1 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL1182967 11681 1 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
CHEMBL274413 11681 1 ACM2 M2 receptor Pig 8.4 pEC50 = 8.4 Binding
Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.
ChEMBL 626 15 0 4 5.9 CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O 10.1021/jm021017q
23657556 12772 0 ACM2 M2 receptor Pig 8.3 pEC50 = 8.3 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 608 16 3 5 6.5 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL1190116 12772 0 ACM2 M2 receptor Pig 8.3 pEC50 = 8.3 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 608 16 3 5 6.5 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1 10.1021/jm070859s
CHEMBL540131 12772 0 ACM2 M2 receptor Pig 8.3 pEC50 = 8.3 Binding
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor
ChEMBL 608 16 3 5 6.5 CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1 10.1021/jm070859s
87934 97390 19 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 210 1 0 3 0.5 CCN1C(=O)CC2(CCN(C)CC2)C1=O 10.1021/jm00050a006
CHEMBL273308 97390 19 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 210 1 0 3 0.5 CCN1C(=O)CC2(CCN(C)CC2)C1=O 10.1021/jm00050a006
CHEMBL542883 97390 19 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional
M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium
ChEMBL 210 1 0 3 0.5 CCN1C(=O)CC2(CCN(C)CC2)C1=O 10.1021/jm00050a006
CHEMBL4762280 180420 0 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 ADMET
Positive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayPositive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay
ChEMBL 409 3 2 8 2.3 Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4cnc(Cl)cn4)C3)c(N)c12 10.1016/j.bmcl.2019.05.026
118714972 113851 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 572 3 1 5 5.3 CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO 10.1021/np500259j
CHEMBL3337861 113851 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 572 3 1 5 5.3 CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO 10.1021/np500259j
10442337 197521 2 ACM2 M2 receptor Human 7.4 pEC50 = 7.4 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 182 2 1 4 1.1 CCOc1noc2c1CNCCC2 10.1021/jm00012a019
CHEMBL69305 197521 2 ACM2 M2 receptor Human 7.4 pEC50 = 7.4 Binding
In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).
ChEMBL 182 2 1 4 1.1 CCOc1noc2c1CNCCC2 10.1021/jm00012a019
118714972 113851 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 572 3 1 5 5.3 CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO 10.1021/np500259j
CHEMBL3337861 113851 0 ACM2 M2 receptor Pig 6.4 pEC50 = 6.4 Binding
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting
ChEMBL 572 3 1 5 5.3 CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO 10.1021/np500259j
122191004 122557 0 ACM2 M2 receptor Human 6.4 pEC50 = 6.4 Functional