Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3658	4076	53	None	1	18	Human	9.5	pAC50	=	9.5	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	1	18	Human	9.5	pAC50	=	9.5	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	1	18	Human	9.5	pAC50	=	9.5	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	1	18	Human	9.5	pAC50	=	9.5	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	1	18	Human	9.5	pAC50	=	9.5	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	11079	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2714	63	None	5	7	Human	9.2	pAC50	=	9.2	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2142	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3074	58	None	-1	18	Human	9.1	pAC50	=	9.1	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1960	2838	67	None	-2	19	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2838	67	None	-2	19	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2838	67	None	-2	19	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2838	67	None	-2	19	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2838	67	None	-2	19	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	11079	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2714	63	None	5	7	Human	8.9	pAC50	=	8.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	46780481	107504	20	None	-7	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-7	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-7	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-7	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	2803	952	58	None	-3	14	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	952	58	None	-3	14	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	952	58	None	-3	14	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	952	58	None	-3	14	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	952	58	None	-3	14	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	1960	2838	67	None	-2	19	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2838	67	None	-2	19	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2838	67	None	-2	19	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2838	67	None	-2	19	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2838	67	None	-2	19	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	129211	3722	78	None	-1	14	Human	8.8	pAC50	=	8.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3722	78	None	-1	14	Human	8.8	pAC50	=	8.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3722	78	None	-1	14	Human	8.8	pAC50	=	8.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3722	78	None	-1	14	Human	8.8	pAC50	=	8.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3722	78	None	-1	14	Human	8.8	pAC50	=	8.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	124	2960	47	None	-8	25	Human	8.7	pAC50	=	8.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2960	47	None	-8	25	Human	8.7	pAC50	=	8.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2960	47	None	-8	25	Human	8.7	pAC50	=	8.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2960	47	None	-8	25	Human	8.7	pAC50	=	8.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2960	47	None	-8	25	Human	8.7	pAC50	=	8.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	16351	102703	47	None	-17	17	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-17	17	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	9429	202110	58	None	-5	18	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202110	58	None	-5	18	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3599	16847	88	None	1	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	20	0	4	5.7	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL125	16847	88	None	1	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	20	0	4	5.7	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	3062316	33545	121	None	-1	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33545	121	None	-1	10	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	54676537	152830	72	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	5	1	6	3.5	CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O	10.1038/s41467-023-40064-9
	CHEMBL397420	152830	72	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	5	1	6	3.5	CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O	10.1038/s41467-023-40064-9
	2162	41484	100	None	-5	22	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-5	22	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	3783	13973	23	None	-27	6	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1197051	13973	23	None	-27	6	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	6989215	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	7391	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	92974	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	971	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	CHEMBL2103827	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	DB06262	1473	80	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	242	469	124	None	-120	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-120	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-120	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-120	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-120	33	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2683	102861	25	None	-812	24	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102861	25	None	-812	24	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102861	25	None	-812	24	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	31101	726	40	None	-199	29	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-199	29	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-199	29	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-199	29	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-199	29	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	9417	133487	54	None	-33	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133487	54	None	-33	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133487	54	None	-33	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	22530	56100	58	None	-3	9	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56100	58	None	-3	9	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56100	58	None	-3	9	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	60860	205616	30	None	-21	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL1615777	205616	30	None	-21	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL818	205616	30	None	-21	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	5354	155632	21	None	-51	10	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL404849	155632	21	None	-51	10	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	2441	98597	24	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	1	1	3	2.6	O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1	10.1038/s41467-023-40064-9
	CHEMBL277062	98597	24	None	-	1	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	1	1	3	2.6	O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1	10.1038/s41467-023-40064-9
	104850	3305	96	None	-1071	28	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3305	96	None	-1071	28	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3305	96	None	-1071	28	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3305	96	None	-1071	28	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3305	96	None	-1071	28	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3346	116	None	-19	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3346	116	None	-19	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3346	116	None	-19	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3346	116	None	-19	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3346	116	None	-19	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	4499	59745	99	None	-6	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59745	99	None	-6	8	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	103	4122	61	None	1	22	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	1	22	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	1	22	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	1	22	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	1	22	Human	8.0	pAC50	=	8.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	10184665	3960	51	None	-645	10	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	-645	10	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	-645	10	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	-645	10	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	-645	10	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	2267	557	71	None	-45	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	557	71	None	-45	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	557	71	None	-45	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	557	71	None	-45	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	557	71	None	-45	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2274	3151	58	None	-24	37	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-24	37	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-24	37	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-24	37	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-24	37	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2601	3751	33	None	-354	17	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-354	17	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-354	17	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-354	17	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-354	17	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	11626560	200914	94	None	-1	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200914	94	None	-1	14	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	10071196	3102	79	None	-831	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	5142	3102	79	None	-831	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	8423	3102	79	None	-831	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	CHEMBL2111101	3102	79	None	-831	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	DB05316	3102	79	None	-831	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	3675	7702	68	None	-91	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1089	7702	68	None	-91	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-363	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-363	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-363	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	2470	3626	50	None	-13803	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-13803	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-13803	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-13803	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-13803	23	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	180	400	56	None	-63	38	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-63	38	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-63	38	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-63	38	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-63	38	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4822	45002	47	None	-16	10	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL152408	45002	47	None	-16	10	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	16351	102703	47	None	-17	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-17	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	37264	189398	24	None	8	3	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL513301	189398	24	None	8	3	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	643976	14486	30	None	-2	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	CHEMBL1201794	14486	30	None	-2	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	72093	35031	9	None	-10	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-10	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-10	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	65016	10177	86	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	CHEMBL116	10177	86	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	22323	15267	32	None	-3	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15267	32	None	-3	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15267	32	None	-3	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	47319	26433	35	None	-4	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	26433	35	None	-4	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	3191	102831	97	None	-660	33	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102831	97	None	-660	33	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	2372	106441	40	None	-144	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106441	40	None	-144	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	216416	111554	48	None	-141	23	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-141	23	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	23480	124064	23	None	-15	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124064	23	None	-15	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	135412795	44721	23	None	-7	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
	CHEMBL1521495	44721	23	None	-7	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
	2805	161866	38	None	-3	9	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161866	38	None	-3	9	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	3053	205111	95	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL780	205111	95	None	1	7	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	1024	1558	27	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1558	27	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1558	27	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1558	27	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1558	27	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	119570	3137	96	None	-10000	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3137	96	None	-10000	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3137	96	None	-10000	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3137	96	None	-10000	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3137	96	None	-10000	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2782	31970	67	None	-3801	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	31970	67	None	-3801	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	31970	67	None	-3801	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	4528	98098	80	None	-5	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL273575	98098	80	None	-5	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	5311017	120578	11	None	-13	5	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3545985	120578	11	None	-13	5	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	26248	161515	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161515	102	None	-1	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1630575	56313	0	None	-2	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	443869	78112	45	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78112	45	None	1	10	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	68555	103085	21	None	-3	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103085	21	None	-3	7	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	15942715	78164	19	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	5	1	5	4.0	CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL2105087	78164	19	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	5	1	5	4.0	CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	6918178	14413	44	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	484	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1200908	14413	44	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	484	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	667492	43875	43	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	234	1	2	3	0.2	CN1C(=O)/C(=N\NC(N)=S)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1512080	43875	43	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	234	1	2	3	0.2	CN1C(=O)/C(=N\NC(N)=S)c2ccccc21	10.1038/s41467-023-40064-9
	3652	4066	79	None	-2089	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4066	79	None	-2089	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4066	79	None	-2089	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4066	79	None	-2089	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4066	79	None	-2089	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	213046	2370	59	None	-6	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-6	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-6	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-6	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-6	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	3351	94973	52	None	-2	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
	CHEMBL254857	94973	52	None	-2	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
	6917906	67743	21	None	-6	5	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	887	35	10	12	1.7	CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1908331	67743	21	None	-6	5	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	887	35	10	12	1.7	CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O	10.1038/s41467-023-40064-9
	98941	46920	17	None	-66	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL154126	46920	17	None	-66	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL4743867	214010	14	None	-4466	15	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3474	38071	57	None	-4	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	CHEMBL146095	38071	57	None	-4	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	49843517	78265	41	None	-40	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2107831	78265	41	None	-40	8	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	3103	41628	49	None	-138	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41628	49	None	-138	9	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16222096	80454	67	None	-50	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80454	67	None	-50	7	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	2580	78366	18	None	-660	10	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL2110775	78366	18	None	-660	10	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	448537	160226	89	None	-54	31	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-54	31	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	16362	3103	71	None	-14	35	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-14	35	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-14	35	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-14	35	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-14	35	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3634	84079	51	None	1	9	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL22077	84079	51	None	1	9	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	3478	5394	103	None	-758	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	445	7	3	6	2.1	Cc1cnc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc2)cn1	10.1038/s41467-023-40064-9
	CHEMBL1073	5394	103	None	-758	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	445	7	3	6	2.1	Cc1cnc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc2)cn1	10.1038/s41467-023-40064-9
	72287	61031	38	None	1	9	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61031	38	None	1	9	Human	7.9	pAC50	=	7.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	19675	51640	43	None	-12	15	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51640	43	None	-12	15	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2284	3160	33	None	-3	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-3	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-3	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-3	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-3	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	2398	951	62	None	-72	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-72	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-72	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-72	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-72	36	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	55483	205074	40	None	-8	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	205074	40	None	-8	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	2869	4121	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4121	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4121	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4121	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4121	89	None	-5011	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	4762	14437	27	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14437	27	None	1	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	5556	203237	27	None	-33	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	342	1	0	4	4.2	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2	10.1038/s41467-023-40064-9
	CHEMBL646	203237	27	None	-33	5	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	342	1	0	4	4.2	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2	10.1038/s41467-023-40064-9
	2218	15251	23	None	-5	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15251	23	None	-5	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	2780	110502	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110502	36	None	-1479	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	9417	133487	54	None	-33	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133487	54	None	-33	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133487	54	None	-33	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	5365247	138404	33	None	-100	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	CHEMBL37744	138404	33	None	-100	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	2318	154832	29	None	-20	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	-20	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	2771	194994	74	None	-46	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-46	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-46	16	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	3950	189484	109	None	-4	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL514	189484	109	None	-4	2	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
	37	775	60	None	-141	12	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-141	12	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-141	12	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-141	12	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-141	12	Human	6.9	pAC50	=	6.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1599	2326	50	None	-7585	21	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2326	50	None	-7585	21	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2326	50	None	-7585	21	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2326	50	None	-7585	21	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2326	50	None	-7585	21	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2723	154022	108	None	-7	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL398440	154022	108	None	-7	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	10.1038/s41467-023-40064-9
	135398737	955	93	None	-17	43	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-17	43	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-17	43	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-17	43	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-17	43	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	5351322	94762	38	None	1	9	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94762	38	None	1	9	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	3117	207818	103	None	-20	24	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL964	207818	103	None	-20	24	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	9818306	14387	15	None	-2	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	1	3	3.8	CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1200430	14387	15	None	-2	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	1	3	3.8	CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12	10.1038/s41467-023-40064-9
	2398	951	62	None	-72	36	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-72	36	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-72	36	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-72	36	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-72	36	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2337	3232	77	None	-4	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-4	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-4	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-4	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-4	29	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1530	2169	50	None	-912	25	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2169	50	None	-912	25	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2169	50	None	-912	25	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2169	50	None	-912	25	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2169	50	None	-912	25	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	243	3180	91	None	-1288	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3052762	3180	91	None	-1288	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3502	3180	91	None	-1288	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	CHEMBL117287	3180	91	None	-1288	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	DB06480	3180	91	None	-1288	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	2351	4269	49	None	-3	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4269	49	None	-3	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4269	49	None	-3	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	21772	78370	31	None	-1000	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL2110816	78370	31	None	-1000	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	4413	98045	57	None	-4	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98045	57	None	-4	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	60151560	167418	39	None	-1	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	439	11	1	5	5.3	CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL4297530	167418	39	None	-1	5	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	439	11	1	5	5.3	CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	216239	23763	118	None	-8	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23763	118	None	-8	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23763	118	None	-8	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	1830	2572	44	None	-416	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2572	44	None	-416	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2572	44	None	-416	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2572	44	None	-416	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2572	44	None	-416	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	196122	112561	55	None	-1	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	478	13	1	6	4.5	CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL3301681	112561	55	None	-1	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	478	13	1	6	4.5	CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O	10.1038/s41467-023-40064-9
	392622	56282	95	None	-8	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56282	95	None	-8	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	1570	57269	97	None	2	3	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	127	0	1	3	1.5	On1ccccc1=S	10.1038/s41467-023-40064-9
	CHEMBL1650619	57269	97	None	2	3	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	127	0	1	3	1.5	On1ccccc1=S	10.1038/s41467-023-40064-9
	1548955	88552	20	None	-43	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88552	20	None	-43	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88552	20	None	-43	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	1155	1616	53	None	-257	11	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1616	53	None	-257	11	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1616	53	None	-257	11	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1616	53	None	-257	11	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1616	53	None	-257	11	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	9270	14398	66	None	-5	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	384	2	0	4	4.4	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1200624	14398	66	None	-5	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	384	2	0	4	4.4	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	3158	56237	27	None	-125	28	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-125	28	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	60663	175645	42	None	-8	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175645	42	None	-8	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175645	42	None	-8	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175645	42	None	-8	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	5994	4609	88	None	-5	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4609	88	None	-5	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	4034	55792	55	None	-12	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-12	18	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	441383	20301	57	None	-165	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20301	57	None	-165	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2470	3626	50	None	-13803	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-13803	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-13803	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-13803	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-13803	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5440	28693	37	None	-1995	16	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28693	37	None	-1995	16	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3926	207218	40	None	-2	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207218	40	None	-2	18	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	31703	194694	63	None	-25	9	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194694	63	None	-25	9	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194694	63	None	-25	9	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2162	41484	100	None	-5	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-5	22	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	5584	203188	44	None	-9	9	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	203188	44	None	-9	9	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4735	195092	96	None	-199	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	195092	96	None	-199	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	195092	96	None	-199	14	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-181	15	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1712	2475	43	None	1	8	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2475	43	None	1	8	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2475	43	None	1	8	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2475	43	None	1	8	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2475	43	None	1	8	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	2865	4112	73	None	-23	20	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-23	20	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-23	20	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-23	20	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-23	20	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	10531	1408	21	None	-301	26	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-301	26	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-301	26	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-301	26	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-301	26	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2286	3161	51	None	-37	28	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-37	28	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-37	28	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-37	28	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-37	28	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	56959	31526	103	None	-3	9	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31526	103	None	-3	9	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31526	103	None	-3	9	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	213	3824	55	None	-18	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3824	55	None	-18	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3824	55	None	-18	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3824	55	None	-18	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3824	55	None	-18	22	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	6231	29739	33	None	-6	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	0	1	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1387	29739	33	None	-6	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	0	1	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	2247	504	81	None	-26	42	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-26	42	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-26	42	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-26	42	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-26	42	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	10180	98841	47	None	-33	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98841	47	None	-33	11	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	9324	9206	60	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL110691	9206	60	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	1662	188681	80	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	162	4	3	3	-0.3	CC(O)(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL50444	188681	80	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	162	4	3	3	-0.3	CC(O)(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	25151352	140581	67	None	-4	11	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140581	67	None	-4	11	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	4046	2466	33	None	-35	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-35	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-35	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-35	17	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	54454	5226	88	None	-7	14	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5226	88	None	-7	14	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	9822750	78380	65	None	-4	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL2111097	78380	65	None	-4	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	119369	2588	74	None	-602	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	2197	2588	74	None	-602	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	4004	2588	74	None	-602	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL420762	2588	74	None	-602	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	2005	78201	91	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	173	6	2	2	0.8	CC(=O)NCCCCCC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL2105922	78201	91	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	173	6	2	2	0.8	CC(=O)NCCCCCC(=O)O	10.1038/s41467-023-40064-9
	2162	41484	100	None	-5	22	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-5	22	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	12555	17929	53	None	-38	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL12610	17929	53	None	-38	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	10133	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	907	78	None	-6	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	657202	12498	6	None	-524	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12498	6	None	-524	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	9911830	19116	100	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1289494	19116	100	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	5281718	34220	84	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	6	8	0.4	OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL142652	34220	84	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	6	8	0.4	OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	4041	99483	18	None	-19	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	1	0	2	3.6	CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL28333	99483	18	None	-19	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	1	0	2	3.6	CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	2695	3812	81	None	-2	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	5504	3812	81	None	-2	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	7310	3812	81	None	-2	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL770	3812	81	None	-2	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00797	3812	81	None	-2	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	45138674	16614	50	None	1	6	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16614	50	None	1	6	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	8569	22611	91	None	-1	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	244	3	2	4	2.3	COc1ccc(C(=O)c2ccccc2O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1326877	22611	91	None	-1	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	244	3	2	4	2.3	COc1ccc(C(=O)c2ccccc2O)c(O)c1	10.1038/s41467-023-40064-9
	24821094	67064	93	None	-6	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67064	93	None	-6	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	3658	4076	53	None	1	18	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	1	18	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	1	18	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	1	18	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	1	18	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	1028	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	289	71	None	1	19	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2146	3078	67	None	-20	15	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3078	67	None	-20	15	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3078	67	None	-20	15	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3078	67	None	-20	15	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3078	67	None	-20	15	Human	8.6	pAC50	=	8.6	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	4151	3580	89	None	1	10	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	3580	89	None	1	10	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	3580	89	None	1	10	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	3580	89	None	1	10	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	3580	89	None	1	10	Human	8.5	pAC50	=	8.5	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	150	2492	21	None	-194	17	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	-194	17	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	-194	17	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	-194	17	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	-194	17	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	135398737	955	93	None	-17	43	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-17	43	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-17	43	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-17	43	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-17	43	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	31729	205761	10	None	-131	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL83063	205761	10	None	-131	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	202	1496	77	None	-3	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-3	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-3	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-3	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-3	17	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	448537	160226	89	None	-54	31	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-54	31	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3035016	12562	50	None	-1	3	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	3	5	10	0.6	CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	CHEMBL1186894	12562	50	None	-1	3	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	3	5	10	0.6	CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	89683805	154409	67	None	-6760	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	473	6	3	8	4.3	CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1	10.1038/s41467-023-40064-9
	CHEMBL3989908	154409	67	None	-6760	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	473	6	3	8	4.3	CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1	10.1038/s41467-023-40064-9
	44439	165663	19	None	-63	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	377	9	3	5	2.8	COc1ccc(CCC(C)NCC(O)c2ccc(O)c([S+](C)[O-])c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL424518	165663	19	None	-63	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	377	9	3	5	2.8	COc1ccc(CCC(C)NCC(O)c2ccc(O)c([S+](C)[O-])c2)cc1	10.1038/s41467-023-40064-9
	444795	139974	105	None	-57	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	10.1038/s41467-023-40064-9
	CHEMBL38	139974	105	None	-57	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	10.1038/s41467-023-40064-9
	5489013	57375	32	None	-21	6	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	CHEMBL1651913	57375	32	None	-21	6	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	1923	104697	136	None	-3	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	1	2	1.9	Oc1cccc2cccnc12	10.1038/s41467-023-40064-9
	CHEMBL310555	104697	136	None	-3	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	1	2	1.9	Oc1cccc2cccnc12	10.1038/s41467-023-40064-9
	1753	2487	28	None	2	4	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	483	2487	28	None	2	4	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	6082	2487	28	None	2	4	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	CHEMBL524	2487	28	None	2	4	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	DB00723	2487	28	None	2	4	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	2726	916	68	None	-29	42	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-29	42	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-29	42	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-29	42	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-29	42	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-363	36	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-363	36	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-363	36	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	214	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-22	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	26248	161515	102	None	-1	11	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161515	102	None	-1	11	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	11289	14406	67	None	-2	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	6	0	3	5.9	COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200761	14406	67	None	-2	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	6	0	3	5.9	COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1	10.1038/s41467-023-40064-9
	2880	97980	49	None	-13	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	97980	49	None	-13	9	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	3356	203345	81	None	-33	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1200822	203345	81	None	-33	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL652	203345	81	None	-33	3	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	54684141	207977	82	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL973	207977	82	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	1499	2078	47	None	-44668	38	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779	2078	47	None	-44668	38	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	536	2078	47	None	-44668	38	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	CHEMBL434	2078	47	None	-44668	38	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	DB01064	2078	47	None	-44668	38	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	16564	204972	32	None	-144	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	CHEMBL76725	204972	32	None	-144	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	2028	2958	80	None	-10715	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	359	2958	80	None	-10715	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	4634	2958	80	None	-10715	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	CHEMBL1231	2958	80	None	-10715	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	DB01062	2958	80	None	-10715	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	34040	28054	72	None	-7244	11	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	CHEMBL1372950	28054	72	None	-7244	11	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	3081361	93905	123	None	-35	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93905	123	None	-35	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	5344	173449	101	None	-3981	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	10.1038/s41467-023-40064-9
	CHEMBL453	173449	101	None	-3981	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	10.1038/s41467-023-40064-9
	3157	1458	71	None	-38	22	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-38	22	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-38	22	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-38	22	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-38	22	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2142	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3074	58	None	-1	18	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1890	2739	49	None	-4	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-4	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-4	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-4	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-4	24	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	10453870	73633	62	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	4	4	6	2.1	OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL2018096	73633	62	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	4	4	6	2.1	OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	9419	35892	35	None	-72	7	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35892	35	None	-72	7	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4601	206724	35	None	-1148	19	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201023	206724	35	None	-1148	19	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL900	206724	35	None	-1148	19	Human	4.6

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Ligand source activities (1 row/activity)