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Ligand source activities (1 row/activity)

Ligand Receptor Assay information Chemical information
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GPCRdb ID #Vendors UniProt IUPHAR Species p-value
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129211 3521 66 ADA1A α1A-adrenoceptor Human 10.2 pEC50 = 10.2 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmc.2016.09.017
2562 3521 66 ADA1A α1A-adrenoceptor Human 10.2 pEC50 = 10.2 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmc.2016.09.017
488 3521 66 ADA1A α1A-adrenoceptor Human 10.2 pEC50 = 10.2 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmc.2016.09.017
CHEMBL836 3521 66 ADA1A α1A-adrenoceptor Human 10.2 pEC50 = 10.2 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmc.2016.09.017
DB00706 3521 66 ADA1A α1A-adrenoceptor Human 10.2 pEC50 = 10.2 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmc.2016.09.017
10934575 198051 0 ADA1A α1A-adrenoceptor Human 10.0 pEC50 = 10.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72441 198051 0 ADA1A α1A-adrenoceptor Human 10.0 pEC50 = 10.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
44362146 164110 1 ADA1A α1A-adrenoceptor Human 9.6 pEC50 = 9.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL422477 164110 1 ADA1A α1A-adrenoceptor Human 9.6 pEC50 = 9.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44574074 186623 0 ADA1A α1A-adrenoceptor Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 2 0 4 2.7 c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL513691 186623 0 ADA1A α1A-adrenoceptor Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 2 0 4 2.7 c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
11109088 197750 0 ADA1A α1A-adrenoceptor Human 9.4 pEC50 = 9.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70751 197750 0 ADA1A α1A-adrenoceptor Human 9.4 pEC50 = 9.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
22493318 44304 0 ADA1A α1A-adrenoceptor Human 9.3 pEC50 = 9.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 241 4 2 4 2.4 c1coc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL152155 44304 0 ADA1A α1A-adrenoceptor Human 9.3 pEC50 = 9.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 241 4 2 4 2.4 c1coc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44362194 33966 1 ADA1A α1A-adrenoceptor Human 9.3 pEC50 = 9.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142784 33966 1 ADA1A α1A-adrenoceptor Human 9.3 pEC50 = 9.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493352 47808 0 ADA1A α1A-adrenoceptor Human 9.2 pEC50 = 9.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155326 47808 0 ADA1A α1A-adrenoceptor Human 9.2 pEC50 = 9.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
22493236 59855 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 242 4 3 5 0.9 c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL17491 59855 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 242 4 3 5 0.9 c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
44271661 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL414185 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44271661 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL414185 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493280 47809 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155327 47809 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44271661 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL414185 160970 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44369431 44899 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccsc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL152693 44899 0 ADA1A α1A-adrenoceptor Human 9.1 pEC50 = 9.1 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccsc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44362208 35011 1 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1csc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL143801 35011 1 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1csc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493258 97969 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL277375 97969 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
44574078 177902 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL468711 177902 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44219718 186009 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1ccc(-c2cncnc2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL506744 186009 0 ADA1A α1A-adrenoceptor Human 9.0 pEC50 = 9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1ccc(-c2cncnc2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44362286 98186 1 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1coc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL279136 98186 1 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1coc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44362195 120320 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL357129 120320 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493263 97393 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 270 5 2 6 1.4 CCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL273316 97393 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 270 5 2 6 1.4 CCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493365 97771 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL275844 97771 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
44329788 201632 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 2.1 CCC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL97859 201632 0 ADA1A α1A-adrenoceptor Human 8.9 pEC50 = 8.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 2.1 CCC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
11098175 197740 0 ADA1A α1A-adrenoceptor Human 8.8 pEC50 = 8.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL70691 197740 0 ADA1A α1A-adrenoceptor Human 8.8 pEC50 = 8.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
10221005 197889 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 267 4 2 5 0.8 Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL71479 197889 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 267 4 2 5 0.8 Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
44362185 120260 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL356605 120260 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493343 63415 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 256 4 2 6 0.9 Cn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18069 63415 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 256 4 2 6 0.9 Cn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44343410 11270 2 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL118055 11270 2 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
9837963 62420 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17851 62420 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44329796 201907 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 7 2 5 2.1 CCCCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL99559 201907 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 7 2 5 2.1 CCCCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493289 49216 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL156661 49216 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
11034737 198093 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72724 198093 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
44362145 34067 3 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 2 4 1.5 c1ccc(-c2ncc[nH]2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142864 34067 3 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 2 4 1.5 c1ccc(-c2ncc[nH]2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493401 201777 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 288 7 2 4 2.0 CCCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL98769 201777 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 288 7 2 4 2.0 CCCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493225 61962 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 270 4 2 6 1.2 Cc1nc(-c2ccccc2NCC2=NCCN2)n(C)n1 10.1016/s0960-894x(03)00050-7
CHEMBL17819 61962 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 270 4 2 6 1.2 Cc1nc(-c2ccccc2NCC2=NCCN2)n(C)n1 10.1016/s0960-894x(03)00050-7
44574878 177693 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1cccc(C2CCc3nc[nH]c3C2)c1 10.1016/j.bmcl.2009.03.162
CHEMBL466916 177693 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1cccc(C2CCc3nc[nH]c3C2)c1 10.1016/j.bmcl.2009.03.162
22493372 119475 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1ncc(-c2ccccc2NCC2=NCCN2)o1 10.1016/s0960-894x(01)00822-8
CHEMBL352225 119475 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1ncc(-c2ccccc2NCC2=NCCN2)o1 10.1016/s0960-894x(01)00822-8
11059195 101463 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 321 4 2 5 1.5 CS(=O)(=O)c1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL302698 101463 0 ADA1A α1A-adrenoceptor Human 6.0 pEC50 = 6.0 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 321 4 2 5 1.5 CS(=O)(=O)c1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
44574987 177819 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 3 0 3 2.8 FC(F)Oc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL467915 177819 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 3 0 3 2.8 FC(F)Oc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
132578519 148908 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 484 10 1 5 4.3 CC(C)Oc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2F)CC1 10.1016/j.bmc.2016.09.017
CHEMBL3947830 148908 0 ADA1A α1A-adrenoceptor Human 8.0 pEC50 = 8.0 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 484 10 1 5 4.3 CC(C)Oc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2F)CC1 10.1016/j.bmc.2016.09.017
76632 99347 47 ADA1A α1A-adrenoceptor Human 5.0 pEC50 = 5.0 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 181 4 1 3 1.2 COc1ccc(OC)c(CCN)c1 10.1021/jm00144a012
CHEMBL287047 99347 47 ADA1A α1A-adrenoceptor Human 5.0 pEC50 = 5.0 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 181 4 1 3 1.2 COc1ccc(OC)c(CCN)c1 10.1021/jm00144a012
44449657 95380 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 265 2 1 3 3.5 Cc1oncc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL260009 95380 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 265 2 1 3 3.5 Cc1oncc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44571891 169176 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 280 3 1 4 2.8 Cc1noc(Cc2cccc3c2CC[C@H]3c2ncc[nH]2)n1 10.1016/j.bmcl.2008.10.066
CHEMBL444252 169176 0 ADA1A α1A-adrenoceptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 280 3 1 4 2.8 Cc1noc(Cc2cccc3c2CC[C@H]3c2ncc[nH]2)n1 10.1016/j.bmcl.2008.10.066
2435 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
395 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
520 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
5386 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
CHEMBL844 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
DB00484 684 91 ADA1A α1A-adrenoceptor Bovine 6.0 pEC50 = 6.0 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
44449690 95474 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 1 2 3.6 c1ccc(-c2cccc3c2CCC3c2ncc[nH]2)nc1 10.1016/j.bmcl.2008.03.070
CHEMBL260575 95474 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 1 2 3.6 c1ccc(-c2cccc3c2CCC3c2ncc[nH]2)nc1 10.1016/j.bmcl.2008.03.070
1960 2687 57 ADA1A α1A-adrenoceptor Rat 5.9 pEC50 = 5.9 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
439260 2687 57 ADA1A α1A-adrenoceptor Rat 5.9 pEC50 = 5.9 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
505 2687 57 ADA1A α1A-adrenoceptor Rat 5.9 pEC50 = 5.9 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
CHEMBL1437 2687 57 ADA1A α1A-adrenoceptor Rat 5.9 pEC50 = 5.9 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
DB00368 2687 57 ADA1A α1A-adrenoceptor Rat 5.9 pEC50 = 5.9 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
44574105 177945 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 305 5 1 4 1.3 CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
CHEMBL469127 177945 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 305 5 1 4 1.3 CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
44574045 186444 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 260 2 0 2 3.9 c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.166
CHEMBL512062 186444 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 260 2 0 2 3.9 c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.166
2765 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
515 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
CHEMBL13852 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
DB09202 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
22493274 10755 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 258 4 2 4 2.1 c1ccc(N2CCCCC2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL117581 10755 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 258 4 2 4 2.1 c1ccc(N2CCCCC2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
10015132 163044 1 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(02)00753-9
CHEMBL420683 163044 1 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(02)00753-9
9817256 197807 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL71001 197807 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
2765 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
515 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
CHEMBL13852 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
DB09202 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
10038958 117975 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1cnsc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
CHEMBL341747 117975 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1cnsc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
10015132 163044 1 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
CHEMBL420683 163044 1 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
22493265 61584 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 284 6 2 6 1.8 CCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17776 61584 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 284 6 2 6 1.8 CCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
2765 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
515 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
CHEMBL13852 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
DB09202 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
44329790 111815 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 247 5 2 5 1.3 CCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL329928 111815 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 247 5 2 5 1.3 CCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493224 201873 2 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 5 3 4 0.9 CCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL99362 201873 2 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 5 3 4 0.9 CCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
2765 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
515 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
CHEMBL13852 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
DB09202 893 13 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
12924821 102185 4 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 207 2 1 3 1.5 COc1ccc(OC)c2c1CCC(N)C2 10.1021/jm00144a012
CHEMBL30596 102185 4 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 207 2 1 3 1.5 COc1ccc(OC)c2c1CCC(N)C2 10.1021/jm00144a012
134154987 150029 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 438 9 1 5 3.4 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.09.017
CHEMBL3956998 150029 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 438 9 1 5 3.4 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 10.1016/j.bmc.2016.09.017
44593577 177613 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
CHEMBL466296 177613 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
44343251 10240 2 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 251 4 2 4 1.4 CS(=O)(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL116843 10240 2 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 251 4 2 4 1.4 CS(=O)(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
44362510 118183 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 267 4 1 4 2.4 Cc1cccc(-c2ccccc2OCC2=NCCN2)n1 10.1016/s0960-894x(01)00764-8
CHEMBL342324 118183 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 267 4 1 4 2.4 Cc1cccc(-c2ccccc2OCC2=NCCN2)n1 10.1016/s0960-894x(01)00764-8
22493257 201182 1 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 272 4 2 4 1.3 O=C(c1ccccc1NCC1=NCCN1)N1CCCC1 10.1016/s0960-894x(01)00569-8
CHEMBL95245 201182 1 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 272 4 2 4 1.3 O=C(c1ccccc1NCC1=NCCN1)N1CCCC1 10.1016/s0960-894x(01)00569-8
51347282 156780 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 430 10 4 6 2.5 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(=O)(=O)C4CC4)c3)ccc12 10.1021/acs.jmedchem.6b01197
CHEMBL4080868 156780 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 430 10 4 6 2.5 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(=O)(=O)C4CC4)c3)ccc12 10.1021/acs.jmedchem.6b01197
44362289 120925 1 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 254 4 1 5 1.5 c1cnc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
CHEMBL358802 120925 1 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 254 4 1 5 1.5 c1cnc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
9813756 8747 0 ADA1A α1A-adrenoceptor Rabbit 5.9 pEC50 = 5.9 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 255 2 2 2 2.8 CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL109848 8747 0 ADA1A α1A-adrenoceptor Rabbit 5.9 pEC50 = 5.9 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 255 2 2 2 2.8 CC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
44449306 94922 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 305 5 2 3 2.6 CCCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL257801 94922 0 ADA1A α1A-adrenoceptor Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 305 5 2 3 2.6 CCCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
118727916 119926 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 335 6 0 3 2.9 O=C1CCCN1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2015.03.009
CHEMBL3400597 119926 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 335 6 0 3 2.9 O=C1CCCN1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2015.03.009
CHEMBL3547118 119926 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 335 6 0 3 2.9 O=C1CCCN1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.bmc.2015.03.009
44449730 155299 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL406316 155299 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
9817256 197807 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL71001 197807 0 ADA1A α1A-adrenoceptor Human 7.9 pEC50 = 7.9 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
134156323 153455 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 455 9 1 6 3.3 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cncc3ccccc23)CC1 10.1016/j.bmc.2016.09.017
CHEMBL3986337 153455 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 455 9 1 6 3.3 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cncc3ccccc23)CC1 10.1016/j.bmc.2016.09.017
44449278 94968 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL257977 94968 0 ADA1A α1A-adrenoceptor Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44574877 177687 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
CHEMBL466869 177687 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
134148920 147648 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 456 9 1 5 3.6 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cc(Cl)ccc2F)CC1 10.1016/j.bmc.2016.09.017
CHEMBL3937911 147648 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 456 9 1 5 3.6 COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cc(Cl)ccc2F)CC1 10.1016/j.bmc.2016.09.017
44574135 186337 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL511211 186337 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1 10.1016/j.bmcl.2009.03.166
22493269 46363 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1ncoc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL154023 46363 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1ncoc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44343257 10220 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 250 4 1 2 3.7 c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1 10.1016/s0960-894x(02)00753-9
CHEMBL116700 10220 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 250 4 1 2 3.7 c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1 10.1016/s0960-894x(02)00753-9
10199052 201485 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 258 5 3 4 1.0 O=C(NC1CC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL97044 201485 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 258 5 3 4 1.0 O=C(NC1CC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
619552 101986 1 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 250 2 0 3 2.5 Cn1nc(Cc2ccccc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL304747 101986 1 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 250 2 0 3 2.5 Cn1nc(Cc2ccccc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
45280075 121589 0 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 430 10 4 6 2.5 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C4CC4)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
CHEMBL3600395 121589 0 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 430 10 4 6 2.5 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C4CC4)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
44343235 9922 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 241 4 1 4 2.6 c1ccc(-c2ccno2)c(OCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL115977 9922 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 241 4 1 4 2.6 c1ccc(-c2ccno2)c(OCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
44362013 34961 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1cc(-c2ccccc2OCC2=NCCN2)sn1 10.1016/s0960-894x(01)00764-8
CHEMBL143766 34961 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1cc(-c2ccccc2OCC2=NCCN2)sn1 10.1016/s0960-894x(01)00764-8
481 2718 2 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1021/jm000542r
9838763 2718 2 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1021/jm000542r
CHEMBL72958 2718 2 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1021/jm000542r
10199335 198309 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74467 198309 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
9944409 7351 0 ADA1A α1A-adrenoceptor Rabbit 7.8 pEC50 = 7.8 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL108804 7351 0 ADA1A α1A-adrenoceptor Rabbit 7.8 pEC50 = 7.8 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
134151231 151409 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 464 11 1 7 2.8 COc1ccc(S(=O)(=O)NCC2CCN(CCOc3ccccc3OC)CC2)cc1OC 10.1016/j.bmc.2016.09.017
CHEMBL3968662 151409 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 464 11 1 7 2.8 COc1ccc(S(=O)(=O)NCC2CCN(CCOc3ccccc3OC)CC2)cc1OC 10.1016/j.bmc.2016.09.017
137657762 158862 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 432 11 4 6 2.7 CCCS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C)n[nH]c3c2)c1 10.1021/acs.jmedchem.6b01197
CHEMBL4104183 158862 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 432 11 4 6 2.7 CCCS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C)n[nH]c3c2)c1 10.1021/acs.jmedchem.6b01197
44574834 171776 1 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.3 c1ccc2c(c1)CC(c1ncc[nH]1)C2 10.1016/j.bmcl.2009.03.162
CHEMBL449279 171776 1 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.3 c1ccc2c(c1)CC(c1ncc[nH]1)C2 10.1016/j.bmcl.2009.03.162
2146 2912 55 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
485 2912 55 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
6041 2912 55 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
CHEMBL1215 2912 55 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
DB00388 2912 55 ADA1A α1A-adrenoceptor Rat 5.8 pEC50 = 5.8 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
44449247 94730 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.8 COc1c(C)ccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL256984 94730 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.8 COc1c(C)ccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44571843 178455 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 242 4 1 2 2.7 COCCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL473425 178455 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 242 4 1 2 2.7 COCCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
76326541 84679 0 ADA1A α1A-adrenoceptor Rabbit 6.8 pEC50 = 6.8 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL2261355 84679 0 ADA1A α1A-adrenoceptor Rabbit 6.8 pEC50 = 6.8 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
44571937 186702 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 282 3 1 3 2.9 Fc1ccn(Cc2cccc3c2CCC3c2ncc[nH]2)n1 10.1016/j.bmcl.2008.10.066
CHEMBL514333 186702 0 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 282 3 1 3 2.9 Fc1ccn(Cc2cccc3c2CCC3c2ncc[nH]2)n1 10.1016/j.bmcl.2008.10.066
9794803 10723 2 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL117381 10723 2 ADA1A α1A-adrenoceptor Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44449692 156171 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 1 3 3.1 c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL407308 156171 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 1 3 3.1 c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
44281493 99293 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 247 2 1 3 2.5 COc1ccc(OC)c2c1CC[C@H]1NCCCC21 10.1021/jm00144a012
CHEMBL286702 99293 0 ADA1A α1A-adrenoceptor Human 6.8 pEC50 = 6.8 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 247 2 1 3 2.5 COc1ccc(OC)c2c1CC[C@H]1NCCCC21 10.1021/jm00144a012
45380469 158932 0 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 432 10 4 6 2.7 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(=O)(=O)C(C)C)c3)ccc12 10.1021/acs.jmedchem.6b01197
CHEMBL4105097 158932 0 ADA1A α1A-adrenoceptor Human 5.8 pEC50 = 5.8 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 432 10 4 6 2.7 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(=O)(=O)C(C)C)c3)ccc12 10.1021/acs.jmedchem.6b01197
44574106 177575 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 317 3 1 3 3.3 CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL466012 177575 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 317 3 1 3 3.3 CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44574107 185925 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL505414 185925 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
44574935 171777 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL449284 171777 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
9794803 10723 2 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL117381 10723 2 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
9859855 59856 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 254 4 2 4 2.1 Cn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17492 59856 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 254 4 2 4 2.1 Cn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
124 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00569-8
2032 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00569-8
4636 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00569-8
CHEMBL762 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00569-8
DB00935 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00569-8
22493320 3958 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 4 2 4 0.8 CN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL100198 3958 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 4 2 4 0.8 CN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44329481 3986 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 289 7 2 5 2.4 CCC(CC)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL100383 3986 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 289 7 2 5 2.4 CCC(CC)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
10378649 107867 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 7 3 4 1.6 CCCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL320419 107867 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 7 3 4 1.6 CCCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
124 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00822-8
2032 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00822-8
4636 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00822-8
CHEMBL762 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00822-8
DB00935 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1016/s0960-894x(01)00822-8
9815005 108934 0 ADA1A α1A-adrenoceptor Rabbit 4.7 pEC50 = 4.7 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL322492 108934 0 ADA1A α1A-adrenoceptor Rabbit 4.7 pEC50 = 4.7 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
134148037 148971 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 450 10 1 7 2.5 COc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3OC)CC2)cc1OC 10.1016/j.bmc.2016.09.017
CHEMBL3948333 148971 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 450 10 1 7 2.5 COc1ccc(S(=O)(=O)NC2CCN(CCOc3ccccc3OC)CC2)cc1OC 10.1016/j.bmc.2016.09.017
11811395 198265 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 281 5 2 5 1.3 CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74071 198265 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 281 5 2 5 1.3 CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
44571844 171712 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 295 4 2 2 3.1 FC(F)(F)CNCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL448510 171712 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 295 4 2 2 3.1 FC(F)(F)CNCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
22493367 65626 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 298 7 2 6 2.2 CCCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18436 65626 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 298 7 2 6 2.2 CCCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44574075 171733 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 0 4 2.9 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL448802 171733 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 0 4 2.9 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
44369351 118847 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 257 4 2 4 2.8 c1csc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL346380 118847 0 ADA1A α1A-adrenoceptor Human 8.7 pEC50 = 8.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 257 4 2 4 2.8 c1csc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
11140347 198098 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72768 198098 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
44362196 34072 1 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142871 34072 1 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44362288 35207 1 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 254 4 1 5 1.5 c1ccc(-c2cnccn2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL143973 35207 1 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 254 4 1 5 1.5 c1ccc(-c2cnccn2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
9881853 97781 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 268 5 2 4 2.6 CCn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL275902 97781 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 268 5 2 4 2.6 CCn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
10198532 201232 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95523 201232 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44369434 44925 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 255 4 2 4 2.7 Cc1ccc(-c2ccccc2NCC2=NCCN2)o1 10.1016/s0960-894x(01)00822-8
CHEMBL152725 44925 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 255 4 2 4 2.7 Cc1ccc(-c2ccccc2NCC2=NCCN2)o1 10.1016/s0960-894x(01)00822-8
9947861 197732 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70634 197732 0 ADA1A α1A-adrenoceptor Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
124 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
2032 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
4636 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
CHEMBL762 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
DB00935 2800 37 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
10422033 120206 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 246 5 2 5 1.5 CO/N=C(\C)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL356195 120206 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 246 5 2 5 1.5 CO/N=C(\C)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44281250 114066 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 247 2 1 3 2.5 COc1ccc(OC)c2c1CC[C@@H]1NCCCC21 10.1021/jm00144a012
CHEMBL33405 114066 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 247 2 1 3 2.5 COc1ccc(OC)c2c1CC[C@@H]1NCCCC21 10.1021/jm00144a012
44449691 95475 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 1 2 3.6 c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1 10.1016/j.bmcl.2008.03.070
CHEMBL260576 95475 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 1 2 3.6 c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1 10.1016/j.bmcl.2008.03.070
4038180 197 10 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
480 197 10 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
CHEMBL109783 197 10 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
44449278 94968 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL257977 94968 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
1960 2687 57 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
439260 2687 57 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
505 2687 57 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
CHEMBL1437 2687 57 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
DB00368 2687 57 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
10135864 121743 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 404 9 4 6 1.9 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
CHEMBL3601200 121743 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 404 9 4 6 1.9 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
10135864 121743 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 404 9 4 6 1.9 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.6b01197
CHEMBL3601200 121743 0 ADA1A α1A-adrenoceptor Human 6.7 pEC50 = 6.7 ADMET
Agonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assayAgonist activity at recombinant human alpha1A adrenergic receptor expressed in HEK293 cells assessed as intercellular Ca mobilization by Fura-2AM dye-based fluorescence assay
ChEMBL 404 9 4 6 1.9 Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.6b01197
44574937 177803 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 0 3 2.2 COc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL467688 177803 0 ADA1A α1A-adrenoceptor Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 0 3 2.2 COc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
44449276 94967 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 241 2 2 2 1.8 CNC(=O)c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL257976 94967 0 ADA1A α1A-adrenoceptor Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 241 2 2 2 1.8 CNC(=O)c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
11090351 162564 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL419448 162564 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
44449278 94968 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL257977 94968 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44593577 177613 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
CHEMBL466296 177613 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
10221004 197801 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70973 197801 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
22493356 46547 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 266 4 2 4 2.5 Cc1cccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL154170 46547 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 266 4 2 4 2.5 Cc1cccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
10804826 23223 1 ADA1A α1A-adrenoceptor Human 4.6 pEC50 = 4.6 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL133451 23223 1 ADA1A α1A-adrenoceptor Human 4.6 pEC50 = 4.6 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
216249 1224 39 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 317 5 2 5 1.4 Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1 10.1016/j.bmcl.2008.03.070
3469 1224 39 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 317 5 2 5 1.4 Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1 10.1016/j.bmcl.2008.03.070
CHEMBL257978 1224 39 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 317 5 2 5 1.4 Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1 10.1016/j.bmcl.2008.03.070
146762 13017 4 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Binding
Effective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear arteryEffective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear artery
ChEMBL 244 5 3 4 0.5 CNCCc1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm00380a017
CHEMBL1191956 13017 4 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Binding
Effective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear arteryEffective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear artery
ChEMBL 244 5 3 4 0.5 CNCCc1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm00380a017
CHEMBL543126 13017 4 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Binding
Effective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear arteryEffective concentration (EC50) against alpha-1-adrenoceptor in the isolated rabbit ear artery
ChEMBL 244 5 3 4 0.5 CNCCc1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm00380a017
10423384 34180 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 272 4 1 4 3.1 Cc1ccc(-c2ccccc2OCC2=NCCN2)s1 10.1016/s0960-894x(01)00764-8
CHEMBL142958 34180 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 272 4 1 4 3.1 Cc1ccc(-c2ccccc2OCC2=NCCN2)s1 10.1016/s0960-894x(01)00764-8
10084685 118686 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1csc(-c2ccccc2OCC2=NCCN2)n1 10.1016/s0960-894x(01)00764-8
CHEMBL344957 118686 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 273 4 1 5 2.5 Cc1csc(-c2ccccc2OCC2=NCCN2)n1 10.1016/s0960-894x(01)00764-8
10221066 162337 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 269 5 2 5 2.0 CCn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
CHEMBL417999 162337 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 269 5 2 5 2.0 CCn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
44271931 97700 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 283 6 2 5 2.4 CCCn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL275386 97700 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 283 6 2 5 2.4 CCCn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
9903797 9167 2 ADA1A α1A-adrenoceptor Rabbit 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
CHEMBL111734 9167 2 ADA1A α1A-adrenoceptor Rabbit 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
10180440 121744 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 420 10 4 7 1.6 COc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
CHEMBL3601201 121744 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 420 10 4 7 1.6 COc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
5487 5560 53 ADA1A α1A-adrenoceptor Bovine 6.6 pEC50 = 6.6 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2nsnc2c1NC1=NCCN1 nan
CHEMBL1079 5560 53 ADA1A α1A-adrenoceptor Bovine 6.6 pEC50 = 6.6 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 253 1 2 6 1.7 Clc1ccc2nsnc2c1NC1=NCCN1 nan
44574138 177651 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 0 4 2.5 Fc1ccc(C2Cc3nccn3C2)c(-n2cccn2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL466635 177651 0 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 0 4 2.5 Fc1ccc(C2Cc3nccn3C2)c(-n2cccn2)c1 10.1016/j.bmcl.2009.03.166
44593557 183041 5 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
CHEMBL481322 183041 5 ADA1A α1A-adrenoceptor Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
11183468 109145 2 ADA1A α1A-adrenoceptor Rabbit 6.6 pEC50 = 6.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL323402 109145 2 ADA1A α1A-adrenoceptor Rabbit 6.6 pEC50 = 6.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
44574874 177542 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 232 1 1 1 3.3 Clc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
CHEMBL465599 177542 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 232 1 1 1 3.3 Clc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
122184771 121745 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 434 11 4 7 2.0 CCOc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
CHEMBL3601202 121745 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 434 11 4 7 2.0 CCOc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12 10.1021/acs.jmedchem.5b00638
44449723 155325 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 1 3 2.9 Cn1nccc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL406348 155325 0 ADA1A α1A-adrenoceptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 1 3 2.9 Cn1nccc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
9950711 108480 0 ADA1A α1A-adrenoceptor Rabbit 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 359 4 2 3 3.2 O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL321644 108480 0 ADA1A α1A-adrenoceptor Rabbit 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 359 4 2 3 3.2 O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
124 2800 37 ADA1A α1A-adrenoceptor Rat 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
2032 2800 37 ADA1A α1A-adrenoceptor Rat 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
4636 2800 37 ADA1A α1A-adrenoceptor Rat 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
CHEMBL762 2800 37 ADA1A α1A-adrenoceptor Rat 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
DB00935 2800 37 ADA1A α1A-adrenoceptor Rat 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
2146 2912 55 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
485 2912 55 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
6041 2912 55 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
CHEMBL1215 2912 55 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
DB00388 2912 55 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
44574134 177650 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL466634 177650 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44574077 177901 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 0 4 3.3 c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL468710 177901 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 0 4 3.3 c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1 10.1016/j.bmcl.2009.03.166
44574136 186203 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(-c2ccn[nH]2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL509350 186203 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(-c2ccn[nH]2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44449725 95503 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 2 2 3.2 Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL260720 95503 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 2 2 3.2 Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44269124 28416 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(02)00753-9
CHEMBL13789 28416 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(02)00753-9
44269124 28416 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
CHEMBL13789 28416 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
10060965 34814 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 256 4 1 4 2.6 Cc1ccoc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
CHEMBL143562 34814 1 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 256 4 1 4 2.6 Cc1ccoc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
9816515 62427 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
CHEMBL17856 62427 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
44329797 107381 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 261 5 2 5 1.7 CC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL319553 107381 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 261 5 2 5 1.7 CC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
10244367 49567 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 6 2 5 1.9 CC/C(=N\OC)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL156950 49567 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 6 2 5 1.9 CC/C(=N\OC)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
11000184 12759 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1190038 12759 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540035 12759 0 ADA1A α1A-adrenoceptor Human 8.5 pEC50 = 8.5 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
44343247 109907 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL325745 109907 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
15959112 197109 0 ADA1A α1A-adrenoceptor Rat 5.5 pEC50 = 5.5 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 280 2 1 5 2.7 Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL66433 197109 0 ADA1A α1A-adrenoceptor Rat 5.5 pEC50 = 5.5 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 280 2 1 5 2.7 Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12 10.1016/j.bmcl.2006.02.003
11264016 98942 2 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 193 2 1 3 1.1 COc1ccc(OC)c2c1CC(N)C2 10.1021/jm00144a012
CHEMBL284307 98942 2 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 193 2 1 3 1.1 COc1ccc(OC)c2c1CC(N)C2 10.1021/jm00144a012
44281507 99224 0 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 233 2 1 3 2.4 COc1ccc(OC)c2c1C1CCC2[C@@H](N)C1 10.1021/jm00144a012
CHEMBL286226 99224 0 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 233 2 1 3 2.4 COc1ccc(OC)c2c1C1CCC2[C@@H](N)C1 10.1021/jm00144a012
44280965 99280 0 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 233 2 1 3 2.4 COc1ccc(OC)c2c1C1CCC2[C@H](N)C1 10.1021/jm00144a012
CHEMBL286609 99280 0 ADA1A α1A-adrenoceptor Human 4.5 pEC50 = 4.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 233 2 1 3 2.4 COc1ccc(OC)c2c1C1CCC2[C@H](N)C1 10.1021/jm00144a012
10804826 23223 1 ADA1A α1A-adrenoceptor Rat 4.5 pEC50 = 4.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL133451 23223 1 ADA1A α1A-adrenoceptor Rat 4.5 pEC50 = 4.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
44593557 183041 5 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2009.03.166
CHEMBL481322 183041 5 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2009.03.166
44593557 183041 5 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL481322 183041 5 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 262 3 1 2 3.3 COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
9816986 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL421011 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
9816986 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00764-8
CHEMBL421011 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00764-8
9816986 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL421011 163315 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44593577 177613 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
CHEMBL466296 177613 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.7 c1ccc(C2CCc3nc[nH]c3C2)cc1 10.1016/j.bmcl.2009.03.162
481 2718 2 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1016/s0960-894x(01)00764-8
9838763 2718 2 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1016/s0960-894x(01)00764-8
CHEMBL72958 2718 2 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 10.1016/s0960-894x(01)00764-8
22493344 97967 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 323 5 2 5 2.5 FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL277361 97967 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 323 5 2 5 2.5 FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44449277 154376 2 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 1 2 2.5 COc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL402388 154376 2 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 1 2 2.5 COc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44449305 154802 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL404566 154802 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44571889 183153 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 264 3 1 3 2.7 c1cc(Cn2cccn2)c2c(c1)[C@H](c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.10.066
CHEMBL482148 183153 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 264 3 1 3 2.7 c1cc(Cn2cccn2)c2c(c1)[C@H](c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.10.066
44449337 154309 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 284 2 2 2 3.5 Clc1ccc2c(c1-c1ccn[nH]1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL402003 154309 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 284 2 2 2 3.5 Clc1ccc2c(c1-c1ccn[nH]1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
22493272 44302 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1nc(-c2ccccc2NCC2=NCCN2)co1 10.1016/s0960-894x(01)00822-8
CHEMBL152154 44302 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1nc(-c2ccccc2NCC2=NCCN2)co1 10.1016/s0960-894x(01)00822-8
118727910 119914 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 427 8 0 3 4.1 O=C1CCCN1CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.03.009
CHEMBL3400594 119914 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 427 8 0 3 4.1 O=C1CCCN1CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.03.009
CHEMBL3547015 119914 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 427 8 0 3 4.1 O=C1CCCN1CCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmc.2015.03.009
44574133 185697 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(C2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL501404 185697 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(C2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
122184835 121766 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 420 10 5 7 1.1 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(CO)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
CHEMBL3601310 121766 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 420 10 5 7 1.1 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(CO)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
44449249 94513 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 Cc1ccc2c(c1NS(C)(=O)=O)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL255938 94513 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 291 3 2 3 2.2 Cc1ccc2c(c1NS(C)(=O)=O)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
10420352 167902 9 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 201 3 4 4 0.5 CNCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
CHEMBL43711 167902 9 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 201 3 4 4 0.5 CNCC(O)c1ccc(O)c(O)c1F 10.1021/jm00118a019
134136412 142152 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 483 10 1 6 4.1 CC(C)Oc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2016.09.017
CHEMBL3894175 142152 0 ADA1A α1A-adrenoceptor Human 7.5 pEC50 = 7.5 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 483 10 1 6 4.1 CC(C)Oc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc3cccnc23)CC1 10.1016/j.bmc.2016.09.017
44280982 99061 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 205 2 1 3 1.3 COc1ccc(OC)c2c1CC1C2[C@@H]1N 10.1021/jm00144a012
CHEMBL285082 99061 0 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 205 2 1 3 1.3 COc1ccc(OC)c2c1CC1C2[C@@H]1N 10.1021/jm00144a012
124 2800 37 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
2032 2800 37 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
4636 2800 37 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
CHEMBL762 2800 37 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
DB00935 2800 37 ADA1A α1A-adrenoceptor Human 6.5 pEC50 = 6.5 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
44574936 177773 0 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccc(C2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.162
CHEMBL467495 177773 0 ADA1A α1A-adrenoceptor Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccc(C2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.162
44369646 119402 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccc(-c2ccccc2NCC2=NCCN2)s1 10.1016/s0960-894x(01)00822-8
CHEMBL351543 119402 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccc(-c2ccccc2NCC2=NCCN2)s1 10.1016/s0960-894x(01)00822-8
44571841 178454 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 228 3 1 2 2.6 COCc1cccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL473424 178454 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 228 3 1 2 2.6 COCc1cccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
44574988 186387 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 227 2 1 3 1.3 NC(=O)c1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL511576 186387 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 227 2 1 3 1.3 NC(=O)c1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
521 1311 55 ADA1A α1A-adrenoceptor Bovine 6.4 pEC50 = 6.4 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C nan
5311068 1311 55 ADA1A α1A-adrenoceptor Bovine 6.4 pEC50 = 6.4 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C nan
835 1311 55 ADA1A α1A-adrenoceptor Bovine 6.4 pEC50 = 6.4 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C nan
CHEMBL778 1311 55 ADA1A α1A-adrenoceptor Bovine 6.4 pEC50 = 6.4 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C nan
DB00633 1311 55 ADA1A α1A-adrenoceptor Bovine 6.4 pEC50 = 6.4 Functional
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C nan
22493349 118930 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1cc(-c2ccccc2NCC2=NCCN2)on1 10.1016/s0960-894x(01)00822-8
CHEMBL347268 118930 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 256 4 2 5 2.1 Cc1cc(-c2ccccc2NCC2=NCCN2)on1 10.1016/s0960-894x(01)00822-8
17804479 94976 10 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.9 c1ccc2c(c1)CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL258007 94976 10 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.9 c1ccc2c(c1)CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
10083742 34190 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 256 4 1 5 1.5 Cn1nccc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
CHEMBL142967 34190 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 256 4 1 5 1.5 Cn1nccc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
44329739 111593 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 287 5 2 5 2.2 O=C(OC1CCCC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL329272 111593 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 287 5 2 5 2.2 O=C(OC1CCCC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
104452 196681 57 ADA1A α1A-adrenoceptor Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL63976 196681 57 ADA1A α1A-adrenoceptor Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12 10.1016/j.bmcl.2006.02.003
22493381 97391 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1cc(-c2ccccc2NCC2=NCCN2)cn1 10.1016/s0960-894x(03)00050-7
CHEMBL273312 97391 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1cc(-c2ccccc2NCC2=NCCN2)cn1 10.1016/s0960-894x(03)00050-7
22493231 201201 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 286 4 2 4 1.7 O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1 10.1016/s0960-894x(01)00569-8
CHEMBL95333 201201 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 286 4 2 4 1.7 O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1 10.1016/s0960-894x(01)00569-8
44574104 186642 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 353 4 1 4 3.3 CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL513871 186642 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 353 4 1 4 3.3 CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
9838376 167465 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 272 4 2 5 2.5 Cc1nc(-c2ccccc2NCC2=NCCN2)cs1 10.1016/s0960-894x(01)00822-8
CHEMBL434074 167465 0 ADA1A α1A-adrenoceptor Human 8.4 pEC50 = 8.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 272 4 2 5 2.5 Cc1nc(-c2ccccc2NCC2=NCCN2)cs1 10.1016/s0960-894x(01)00822-8
11108001 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117248 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540542 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
9816460 119133 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL349082 119133 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
1028 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
139148732 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
479 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
5816 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
CHEMBL679 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
DB00668 276 64 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm00118a019
11058166 198269 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74114 198269 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1 10.1021/jm000542r
44574986 186369 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 202 1 0 2 2.4 Fc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL511411 186369 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 202 1 0 2 2.4 Fc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
22493415 49498 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 268 4 3 6 1.1 Nc1nccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(01)00822-8
CHEMBL156893 49498 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 268 4 3 6 1.1 Nc1nccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(01)00822-8
44449686 95398 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 1 3 3.6 c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL260116 95398 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 1 3 3.6 c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
25066019 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL256982 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
25066019 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
CHEMBL256982 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
25066019 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL256982 94728 0 ADA1A α1A-adrenoceptor Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
11079593 197686 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70326 197686 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
15959119 76465 0 ADA1A α1A-adrenoceptor Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 310 4 0 3 3.8 C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207277 76465 0 ADA1A α1A-adrenoceptor Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
ChEMBL 310 4 0 3 3.8 C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
9904117 9131 2 ADA1A α1A-adrenoceptor Rabbit 6.4 pEC50 = 6.4 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111554 9131 2 ADA1A α1A-adrenoceptor Rabbit 6.4 pEC50 = 6.4 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
44369647 46742 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnoc2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL154346 46742 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnoc2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44449248 94512 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 248 2 1 2 3.2 COc1c(Cl)ccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL255937 94512 0 ADA1A α1A-adrenoceptor Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 248 2 1 2 3.2 COc1c(Cl)ccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44449338 95007 1 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.5 c1ccc2c(c1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL258178 95007 1 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.5 c1ccc2c(c1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44449338 95007 1 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.5 c1ccc2c(c1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
CHEMBL258178 95007 1 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 1 1 2.5 c1ccc2c(c1)CCC2c1ncc[nH]1 10.1016/j.bmcl.2009.03.162
44593580 177688 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 242 3 1 2 2.8 COCc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
CHEMBL466876 177688 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 242 3 1 2 2.8 COCc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
11747739 12942 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1191324 12942 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL542402 12942 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
44574103 171744 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 0 4 2.4 c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL448908 171744 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 0 4 2.4 c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44574137 186249 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 0 4 2.5 Fc1ccc(-n2cccn2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL510023 186249 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 0 4 2.5 Fc1ccc(-n2cccn2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
11108001 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL117248 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL540542 10591 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
44362149 33517 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142387 33517 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44362150 118640 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 2 4 1.5 c1ccc(-c2cc[nH]n2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL344551 118640 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 2 4 1.5 c1ccc(-c2cc[nH]n2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
10859076 13388 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1194763 13388 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL553276 13388 0 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
6604803 115775 2 ADA1A α1A-adrenoceptor Rat 8.3 pEC50 = 8.3 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL336161 115775 2 ADA1A α1A-adrenoceptor Rat 8.3 pEC50 = 8.3 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
6604803 115775 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL336161 115775 2 ADA1A α1A-adrenoceptor Human 8.3 pEC50 = 8.3 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
4038180 197 10 ADA1A α1A-adrenoceptor Rat 8.2 pEC50 = 8.2 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
480 197 10 ADA1A α1A-adrenoceptor Rat 8.2 pEC50 = 8.2 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
CHEMBL109783 197 10 ADA1A α1A-adrenoceptor Rat 8.2 pEC50 = 8.2 Functional
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
9816461 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL117094 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL544290 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
44343245 109887 2 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 256 4 2 3 3.0 c1ccc(N2CCCCC2)c(NCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL325648 109887 2 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 256 4 2 3 3.0 c1ccc(N2CCCCC2)c(NCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
44343275 110047 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 240 4 2 4 2.7 c1ccc(-c2cnco2)c(NCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL326067 110047 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 240 4 2 4 2.7 c1ccc(-c2cnco2)c(NCc2c[nH]cn2)c1 10.1016/s0960-894x(02)00753-9
22493233 168448 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 268 4 2 4 2.4 Cc1ccc(-c2ccccc2NCC2=NCCN2)n1C 10.1016/s0960-894x(03)00050-7
CHEMBL441412 168448 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 268 4 2 4 2.4 Cc1ccc(-c2ccccc2NCC2=NCCN2)n1C 10.1016/s0960-894x(03)00050-7
9903313 171833 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL450018 171833 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493379 201655 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 3 4 1.2 CC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL98016 201655 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 3 4 1.2 CC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493411 167196 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 3 4 1.6 CCC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL432192 167196 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 3 4 1.6 CCC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44329701 201214 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 1.9 CC(C)COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95398 201214 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 1.9 CC(C)COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44574044 177580 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 209 1 0 3 2.1 N#Cc1ccccc1[C@@H]1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
CHEMBL466046 177580 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 209 1 0 3 2.1 N#Cc1ccccc1[C@@H]1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
44219719 177820 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 209 1 0 3 2.1 N#Cc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL467916 177820 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 209 1 0 3 2.1 N#Cc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
3584 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2015.03.009
5401 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2015.03.009
7302 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2015.03.009
CHEMBL611 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2015.03.009
DB01162 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2015.03.009
10399043 119401 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 232 5 2 5 1.1 CO/N=C/c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL351542 119401 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 232 5 2 5 1.1 CO/N=C/c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
3584 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2016.09.017
5401 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2016.09.017
7302 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2016.09.017
CHEMBL611 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2016.09.017
DB01162 3547 54 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmc.2016.09.017
10916464 197723 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70563 197723 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1 10.1021/jm000542r
44574875 185809 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 232 1 1 1 3.3 Clc1cccc(C2CCc3nc[nH]c3C2)c1 10.1016/j.bmcl.2009.03.162
CHEMBL503269 185809 0 ADA1A α1A-adrenoceptor Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 232 1 1 1 3.3 Clc1cccc(C2CCc3nc[nH]c3C2)c1 10.1016/j.bmcl.2009.03.162
44449245 94729 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL256983 94729 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
22493347 118857 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 6 2 5 1.9 CCO/N=C(\C)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL346465 118857 0 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 260 6 2 5 1.9 CCO/N=C(\C)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44281057 98971 0 ADA1A α1A-adrenoceptor Human 5.3 pEC50 = 5.3 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 221 2 1 3 1.9 COc1ccc(OC)c2c1CCCC(N)C2 10.1021/jm00144a012
CHEMBL284486 98971 0 ADA1A α1A-adrenoceptor Human 5.3 pEC50 = 5.3 Functional
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
ChEMBL 221 2 1 3 1.9 COc1ccc(OC)c2c1CCCC(N)C2 10.1021/jm00144a012
9796525 9136 0 ADA1A α1A-adrenoceptor Rabbit 5.3 pEC50 = 5.3 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1007/s00044-004-0020-z
CHEMBL111584 9136 0 ADA1A α1A-adrenoceptor Rabbit 5.3 pEC50 = 5.3 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1007/s00044-004-0020-z
2146 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assayAgonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2015.03.009
485 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assayAgonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2015.03.009
6041 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assayAgonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2015.03.009
CHEMBL1215 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assayAgonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2015.03.009
DB00388 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assayAgonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2015.03.009
2146 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2016.09.017
485 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2016.09.017
6041 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2016.09.017
CHEMBL1215 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2016.09.017
DB00388 2912 55 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Binding
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1016/j.bmc.2016.09.017
9816461 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117094 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL544290 10439 3 ADA1A α1A-adrenoceptor Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
10267873 109933 0 ADA1A α1A-adrenoceptor Rabbit 5.3 pEC50 = 5.3 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1007/s00044-004-0020-z
CHEMBL325897 109933 0 ADA1A α1A-adrenoceptor Rabbit 5.3 pEC50 = 5.3 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1007/s00044-004-0020-z
44574938 186077 0 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 0 3 2.2 COc1cccc(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.162
CHEMBL507755 186077 0 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 214 2 0 3 2.2 COc1cccc(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.162
44571888 183040 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1cc(F)cc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL481321 183040 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1cc(F)cc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
44343244 9678 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 241 3 3 4 2.0 Oc1ccc2cccc(NCC3=NCCN3)c2c1 10.1016/s0960-894x(02)00753-9
CHEMBL114669 9678 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 241 3 3 4 2.0 Oc1ccc2cccc(NCC3=NCCN3)c2c1 10.1016/s0960-894x(02)00753-9
44343236 110638 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 243 4 1 5 1.7 c1ccc(-c2ccno2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL327005 110638 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 243 4 1 5 1.7 c1ccc(-c2ccno2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
9903932 58976 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 284 5 2 6 1.9 CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17151 58976 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 284 5 2 6 1.9 CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44271932 64655 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18256 64655 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493392 46690 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL154298 46690 0 ADA1A α1A-adrenoceptor Human 8.2 pEC50 = 8.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
9838192 110586 10 ADA1A α1A-adrenoceptor Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1016/j.bmc.2008.02.091
CHEMBL326702 110586 10 ADA1A α1A-adrenoceptor Rabbit 7.2 pEC50 = 7.2 Functional
Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1016/j.bmc.2008.02.091
9838192 110586 10 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Binding
Effective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptorEffective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
CHEMBL326702 110586 10 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Binding
Effective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptorEffective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
9838192 110586 10 ADA1A α1A-adrenoceptor Rabbit 6.2 pEC50 = 6.2 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
CHEMBL326702 110586 10 ADA1A α1A-adrenoceptor Rabbit 6.2 pEC50 = 6.2 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
122184772 121746 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 424 9 4 6 2.3 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(Cl)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
CHEMBL3601203 121746 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
ChEMBL 424 9 4 6 2.3 CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(Cl)n[nH]c3c2)c1 10.1021/acs.jmedchem.5b00638
44574132 177734 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1cccc(-c2cncnc2)c1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
CHEMBL467259 177734 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 280 2 0 4 2.8 Fc1cccc(-c2cncnc2)c1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.166
44571842 178406 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 242 4 1 2 3.0 CCOCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL473043 178406 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 242 4 1 2 3.0 CCOCc1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
44571887 185737 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1c(F)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL502078 185737 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1c(F)ccc2c1CC[C@H]2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
44343243 9572 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 239 3 3 3 2.9 Oc1ccc2cccc(NCc3c[nH]cn3)c2c1 10.1016/s0960-894x(02)00753-9
CHEMBL114054 9572 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 239 3 3 3 2.9 Oc1ccc2cccc(NCc3c[nH]cn3)c2c1 10.1016/s0960-894x(02)00753-9
44343173 10738 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 272 6 2 3 2.5 CCN(CC)C(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL117482 10738 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 272 6 2 3 2.5 CCN(CC)C(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
9838294 59138 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 269 5 2 5 2.0 CCn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17221 59138 0 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
ChEMBL 269 5 2 5 2.0 CCn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
11079 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
3369 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
4436 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
5509 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
CHEMBL761 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
DB06711 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00569-8
11079 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
3369 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
4436 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
5509 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
CHEMBL761 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
DB06711 2570 53 ADA1A α1A-adrenoceptor Human 7.2 pEC50 = 7.2 Functional
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2 10.1016/s0960-894x(01)00822-8
9926529 9118 2 ADA1A α1A-adrenoceptor Rabbit 6.2 pEC50 = 6.2 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111496 9118 2 ADA1A α1A-adrenoceptor Rabbit 6.2 pEC50 = 6.2 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
25154770 182775 0 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1ccc(F)c2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
CHEMBL480272 182775 0 ADA1A α1A-adrenoceptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
ChEMBL 246 3 1 2 2.8 COCc1ccc(F)c2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.10.066
9879119 9174 0 ADA1A α1A-adrenoceptor Rabbit 7.2 pEC50 = 7.2 Binding
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1007/s00044-004-0020-z