Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11504295	2902	47	None	416	8	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2902	47	None	416	8	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2902	47	None	416	8	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2902	47	None	416	8	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2902	47	None	416	8	Human	8.8	pAC50	=	8.8	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	12582	947	45	None	-2	7	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	2783	947	45	None	-2	7	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	CHEMBL49080	947	45	None	-2	7	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	DB01407	947	45	None	-2	7	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	3	3	3.0	CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O	10.1038/s41467-023-40064-9
	1499	2078	47	None	-91	38	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779	2078	47	None	-91	38	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	536	2078	47	None	-91	38	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	CHEMBL434	2078	47	None	-91	38	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	DB01064	2078	47	None	-91	38	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	1028	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	289	71	None	-5	19	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	105	3435	91	None	-13	3	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	2083	3435	91	None	-13	3	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	558	3435	91	None	-13	3	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL714	3435	91	None	-13	3	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	DB01001	3435	91	None	-13	3	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1038/s41467-023-40064-9
	1155	1616	53	None	-1	11	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1616	53	None	-1	11	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1616	53	None	-1	11	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1616	53	None	-1	11	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1616	53	None	-1	11	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	2419	3437	84	None	10	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3437	84	None	10	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3437	84	None	10	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3437	84	None	10	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3437	84	None	10	14	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	643976	14486	30	None	2	3	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	CHEMBL1201794	14486	30	None	2	3	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	2146	3078	67	None	-691	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3078	67	None	-691	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3078	67	None	-691	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3078	67	None	-691	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3078	67	None	-691	15	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	10184665	3960	51	None	40	10	Human	8.2	pAC50	=	8.2	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3960	51	None	40	10	Human	8.2	pAC50	=	8.2	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3960	51	None	40	10	Human	8.2	pAC50	=	8.2	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3960	51	None	40	10	Human	8.2	pAC50	=	8.2	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3960	51	None	40	10	Human	8.2	pAC50	=	8.2	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	5606	10161	67	None	3	2	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1159717	10161	67	None	3	2	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	227	3	2	2	2.8	CC(C)(C)NCC(O)c1ccccc1Cl	10.1038/s41467-023-40064-9
	4567	9916	34	None	-2	12	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9916	34	None	-2	12	Human	7.1	pAC50	=	7.1	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	6083	204792	95	None	-19	7	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1315633	204792	95	None	-19	7	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL752	204792	95	None	-19	7	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1038/s41467-023-40064-9
	68555	103085	21	None	-229	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103085	21	None	-229	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human ADRB2 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	164617688	188498	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847536	188498	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028449	188498	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164622954	188542	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4871708	188542	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028726	188542	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164625303	188565	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4873082	188565	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028871	188565	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164617772	188500	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848793	188500	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028458	188500	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164615126	188480	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854569	188480	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028293	188480	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156010908	178309	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4634131	178309	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651173	178309	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164623230	188547	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865710	188547	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028744	188547	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164618278	188503	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848018	188503	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028489	188503	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164615492	188485	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848704	188485	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028319	188485	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164623105	188544	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4862449	188544	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028738	188544	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164611794	188451	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854261	188451	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028104	188451	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164612025	188453	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4860454	188453	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028117	188453	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164618895	188511	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868938	188511	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028525	188511	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164610792	188444	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4855974	188444	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028040	188444	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	11504295	2902	47	None	416	8	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	4814	2902	47	None	416	8	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	7543	2902	47	None	416	8	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	CHEMBL605846	2902	47	None	416	8	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	DB09080	2902	47	None	416	8	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	9957764	88678	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	503	11	6	6	3.6	COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL236039	88678	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	503	11	6	6	3.6	COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	11259765	85981	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	462	11	5	5	3.4	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	CHEMBL230486	85981	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	462	11	5	5	3.4	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	11621158	16670	1	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1242943	16670	1	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155517986	170183	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	170183	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155517986	170183	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	170183	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164621302	188527	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863282	188527	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028641	188527	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164623918	188554	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872480	188554	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028793	188554	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	44434130	88681	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	5	5	3.9	C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL236041	88681	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	5	5	3.9	C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	164615222	188482	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4857267	188482	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028301	188482	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164622827	188540	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868585	188540	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028721	188540	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	11455274	16692	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	12	5	6	3.3	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243189	16692	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	12	5	6	3.3	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	164624634	188561	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868684	188561	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028836	188561	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014115	178266	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4635163	178266	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650951	178266	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	11214499	85983	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	516	11	5	5	4.3	C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	CHEMBL230490	85983	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	516	11	5	5	4.3	C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	164608750	188434	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4846631	188434	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5027923	188434	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	156015148	178261	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4646881	178261	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650929	178261	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164620479	188520	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863847	188520	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028596	188520	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	11249243	16689	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	511	12	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243158	16689	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	511	12	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	156015482	178228	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4641262	178228	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4650664	178228	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	164619360	188514	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868763	188514	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028547	188514	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164623544	188550	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872653	188550	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028764	188550	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	164612078	188454	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848617	188454	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028119	188454	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014817	178280	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4642770	178280	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650993	178280	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164617235	188495	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4848775	188495	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028422	188495	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	156013777	178324	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4636255	178324	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651241	178324	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	10390417	167741	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	480	10	6	7	3.0	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL430361	167741	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	480	10	6	7	3.0	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	49864395	15605	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2010.06.136
	CHEMBL1221680	15605	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2010.06.136
	11477877	16715	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	517	12	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243348	16715	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	517	12	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	13121366	177431	0	None	457	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	370	7	4	5	2.8	CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4638864	177431	0	None	457	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	370	7	4	5	2.8	CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164612262	188455	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4853372	188455	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028127	188455	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164614743	188475	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4860764	188475	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028269	188475	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014962	178226	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4645203	178226	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4650644	178226	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	155536314	172151	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4473515	172151	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	155536314	172151	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4473515	172151	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	164620585	188521	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4866766	188521	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028602	188521	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	44434126	88680	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	519	11	6	6	4.3	CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL236040	88680	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	519	11	6	6	4.3	CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	10027868	144867	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	474	10	6	6	2.9	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL391006	144867	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	474	10	6	6	2.9	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	164618813	188510	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865833	188510	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028523	188510	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164623433	188548	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4870623	188548	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028756	188548	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	156014983	178306	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4644638	178306	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651152	178306	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	11261001	16693	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	13	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243190	16693	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	13	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	11489605	16700	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	541	13	5	7	2.9	COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243256	16700	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	541	13	5	7	2.9	COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	155533625	171853	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4469364	171853	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155564766	175465	0	None	181	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4577508	175465	0	None	181	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	11489574	16697	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	14	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243222	16697	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	14	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155536813	172182	0	None	263	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4473790	172182	0	None	263	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164624092	188557	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4865514	188557	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028807	188557	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	2419	3437	84	None	10	14	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	5152	3437	84	None	10	14	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	559	3437	84	None	10	14	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	CHEMBL1263	3437	84	None	10	14	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	DB00938	3437	84	None	10	14	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	11699773	16684	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	569	12	6	7	3.6	Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243101	16684	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	569	12	6	7	3.6	Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	164626310	188571	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4874945	188571	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028930	188571	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	11398811	16703	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	555	14	5	7	3.3	CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243285	16703	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	555	14	5	7	3.3	CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	155543358	174749	0	None	102	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4561253	174749	0	None	102	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	156015401	178247	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4645694	178247	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4650809	178247	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	156015798	178254	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4649233	178254	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4650858	178254	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	44434125	146086	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	473	10	6	5	3.6	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL391946	146086	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	473	10	6	5	3.6	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	44237865	58201	0	None	-	1	Guinea pig	10.3	pEC50	=	10.3	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	500	11	6	5	3.9	O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682213	58201	0	None	-	1	Guinea pig	10.3	pEC50	=	10.3	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	500	11	6	5	3.9	O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	155557083	174517	0	None	724	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4556022	174517	0	None	724	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	10389119	88725	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	451	10	6	5	3.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL236251	88725	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	451	10	6	5	3.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	155564340	175400	0	None	263	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	CHEMBL4576089	175400	0	None	263	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	44434127	88578	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	509	10	6	5	3.8	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL235612	88578	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	509	10	6	5	3.8	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	3466	4111	44	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	37990	4111	44	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	CHEMBL1243407	4111	44	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	1499	2078	47	None	-91	38	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	3779	2078	47	None	-91	38	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	536	2078	47	None	-91	38	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	CHEMBL434	2078	47	None	-91	38	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	DB01064	2078	47	None	-91	38	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	11376125	16708	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	12	5	6	3.5	Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C	10.1021/jm1005989
	CHEMBL1243317	16708	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	12	5	6	3.5	Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C	10.1021/jm1005989
	164614249	188470	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4859591	188470	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028241	188470	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	10324803	89566	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	533	12	6	7	3.6	COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL237501	89566	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	533	12	6	7	3.6	COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	10390752	146231	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	6	5	4.1	C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL392056	146231	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	6	5	4.1	C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	16049087	64053	0	None	125	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807817	64053	0	None	125	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	9892481	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	CHEMBL1940832	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	90645347	112486	0	None	7	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298987	112486	0	None	7	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	9892481	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.069
	CHEMBL1940832	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.069
	9892481	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940832	70204	14	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	11420492	155176	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	492	10	5	5	3.8	C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	CHEMBL402501	155176	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	492	10	5	5	3.8	C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	155564079	175387	0	None	97	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4575759	175387	0	None	97	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	11456127	16714	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	593	12	5	6	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243347	16714	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	593	12	5	6	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	44237667	58198	0	None	-	1	Guinea pig	10.2	pEC50	=	10.2	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	458	8	6	5	3.7	O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682210	58198	0	None	-	1	Guinea pig	10.2	pEC50	=	10.2	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	458	8	6	5	3.7	O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	2419	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	5152	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	559	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	CHEMBL1263	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	DB00938	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	2419	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	5152	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	559	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	CHEMBL1263	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	DB00938	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	2419	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	5152	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	559	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	CHEMBL1263	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	DB00938	3437	84	None	10	14	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	45269924	195425	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction	ChEMBL	283	6	5	6	-0.1	CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1	10.1016/j.ejmech.2008.12.016
	CHEMBL552398	195425	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction	ChEMBL	283	6	5	6	-0.1	CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1	10.1016/j.ejmech.2008.12.016
	164615474	188484	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847767	188484	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028315	188484	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	155548071	173725	0	None	131	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4536813	173725	0	None	131	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	155567283	175946	0	None	588	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	CHEMBL4588479	175946	0	None	588	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	155548668	173759	0	None	-	1	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4537644	173759	0	None	-	1	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	2419	3437	84	None	10	14	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	5152	3437	84	None	10	14	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	559	3437	84	None	10	14	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	CHEMBL1263	3437	84	None	10	14	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	DB00938	3437	84	None	10	14	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	16049088	64054	0	None	100	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807818	64054	0	None	100	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	16049028	64055	0	None	50	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807819	64055	0	None	50	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	11592062	112430	0	None	25	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298325	112430	0	None	25	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	11169365	112485	0	None	22	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298986	112485	0	None	22	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	155513474	169716	0	None	83	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4438531	169716	0	None	83	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164622775	188539	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4867311	188539	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028718	188539	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	11504295	2902	47	None	416	8	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	4814	2902	47	None	416	8	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	7543	2902	47	None	416	8	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	CHEMBL605846	2902	47	None	416	8	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	DB09080	2902	47	None	416	8	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	44237615	58200	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	486	10	6	5	3.5	O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682212	58200	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	486	10	6	5	3.5	O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	11707090	16680	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243068	16680	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	164623583	188552	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4873280	188552	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028767	188552	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	11247541	85935	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	434	11	5	5	2.6	O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1	10.1016/j.bmcl.2007.04.081
	CHEMBL230203	85935	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	434	11	5	5	2.6	O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1	10.1016/j.bmcl.2007.04.081
	44425580	85982	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	448	11	5	5	3.0	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	CHEMBL230487	85982	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	448	11	5	5	3.0	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	57334265	70829	0	None	-	1	Guinea pig	10.0	pEC50	=	10	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	538	13	4	8	3.4	COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC	10.1016/j.bmcl.2012.01.013
	CHEMBL1951067	70829	0	None	-	1	Guinea pig	10.0	pEC50	=	10	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	538	13	4	8	3.4	COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC	10.1016/j.bmcl.2012.01.013
	12065	625	26	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	45483813	625	26	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	CHEMBL579394	625	26	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	13345218	197198	0	None	8	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568272	197198	0	None	8	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	16049024	64056	0	None	79	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	498	13	4	7	4.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807820	64056	0	None	79	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	498	13	4	7	4.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	118737358	119039	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	13	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1021/jm501915g
	CHEMBL3426706	119039	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	13	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1021/jm501915g
	10239722	112431	0	None	11	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298326	112431	0	None	11	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	66796015	112433	0	None	35	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298328	112433	0	None	35	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	10180590	70202	0	None	707	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940830	70202	0	None	707	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	105	3435	91	None	-13	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	2083	3435	91	None	-13	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	558	3435	91	None	-13	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	CHEMBL714	3435	91	None	-13	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	DB01001	3435	91	None	-13	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	10392857	88630	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	552	11	7	7	2.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL235818	88630	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	552	11	7	7	2.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	3083544	26778	51	None	2	6	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmcl.2012.01.013
	CHEMBL1200811	26778	51	None	2	6	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmcl.2012.01.013
	CHEMBL1363	26778	51	None	2	6	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmcl.2012.01.013
	CHEMBL1951071	26778	51	None	2	6	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmcl.2012.01.013
	CHEMBL605993	26778	51	None	2	6	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1016/j.bmcl.2012.01.013
	16049026	64057	0	None	25	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	432	13	4	7	2.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807821	64057	0	None	25	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	432	13	4	7	2.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	16049029	64058	0	None	25	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	482	13	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807822	64058	0	None	25	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	482	13	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	10461973	119030	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	655	15	6	8	4.9	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426697	119030	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	655	15	6	8	4.9	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	9871386	112244	5	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3290999	112244	5	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	90645344	112429	0	None	7	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	CHEMBL3298324	112429	0	None	7	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	56943545	112435	0	None	28	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298330	112435	0	None	28	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	11180293	112481	0	None	22	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298897	112481	0	None	22	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	46832232	14183	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1085837	14183	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1198923	14183	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	10217757	112243	0	None	10	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290998	112243	0	None	10	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	9871386	112244	5	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290999	112244	5	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	57398384	70205	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	459	10	6	6	3.2	O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2011.11.072
	CHEMBL1940833	70205	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	459	10	6	6	3.2	O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2011.11.072
	156015656	178319	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4639822	178319	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651230	178319	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	53323515	58202	0	None	-	1	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	515	10	7	6	2.5	NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682214	58202	0	None	-	1	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	515	10	7	6	2.5	NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1	10.1016/j.bmcl.2010.12.096
	46938907	16677	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243035	16677	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155524038	170867	0	None	120	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4454489	170867	0	None	120	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	2419	3437	84	None	10	14	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	5152	3437	84	None	10	14	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	559	3437	84	None	10	14	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	CHEMBL1263	3437	84	None	10	14	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	DB00938	3437	84	None	10	14	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	156020412	178325	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4648525	178325	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651243	178325	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	155550964	173926	0	None	575	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4541263	173926	0	None	575	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	1499	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	3779	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	536	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	CHEMBL434	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	DB01064	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	1499	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	3779	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	536	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	CHEMBL434	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	DB01064	2078	47	None	-91	38	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	10394806	119031	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	681	12	6	8	5.3	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1	10.1021/jm501915g
	CHEMBL3426698	119031	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	681	12	6	8	5.3	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1	10.1021/jm501915g
	118737354	119034	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	703	12	6	8	5.8	Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426701	119034	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	703	12	6	8	5.8	Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	56943518	112434	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298329	112434	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943546	112451	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298691	112451	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	24901144	70300	0	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944691	70300	0	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	10288976	66550	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835862	66550	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852543	66550	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	9849126	12407	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL1185969	12407	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL443435	12407	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	9891927	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL446840	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483200	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483201	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	9891927	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL446840	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483200	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483201	184173	9	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	155551133	173972	0	None	446	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4542430	173972	0	None	446	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	44434128	149115	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	489	10	7	6	3.3	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL394339	149115	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	489	10	7	6	3.3	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	11534330	16674	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243000	16674	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	156020206	178318	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4648663	178318	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651226	178318	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	156015463	178327	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4640925	178327	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651254	178327	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	1239	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	3410	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	3465	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	CHEMBL1256786	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	DB00983	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	56658246	64467	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814277	64467	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814278	64467	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	24901413	70327	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	CHEMBL1945032	70327	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	15981386	63520	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr	ChEMBL	459	12	4	7	2.0	CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1	10.1016/j.bmcl.2011.04.135
	CHEMBL1800472	63520	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr	ChEMBL	459	12	4	7	2.0	CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1	10.1016/j.bmcl.2011.04.135
	56663238	64072	0	None	251	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807872	64072	0	None	251	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	11857427	119026	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1	10.1021/jm501915g
	CHEMBL3426693	119026	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1	10.1021/jm501915g
	118737350	119027	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426694	119027	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	1239	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3410	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3465	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	CHEMBL1256786	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	DB00983	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	16738927	70329	0	None	31	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1945034	70329	0	None	31	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	42625823	12647	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187371	12647	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL500782	12647	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	1239	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3410	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3465	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	CHEMBL1256786	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	DB00983	1664	55	None	-2	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	44237612	58199	0	None	4466	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682211	58199	0	None	4466	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237613	58203	0	None	2754	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682215	58203	0	None	2754	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237614	58204	0	None	31622	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682216	58204	0	None	31622	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237669	58205	0	None	7943	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682217	58205	0	None	7943	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237666	58206	0	None	44668	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682218	58206	0	None	44668	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	45483810	197121	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL567863	197121	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	1499	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	3779	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	536	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	CHEMBL434	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	DB01064	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	11577915	16576	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	591	12	6	7	4.1	CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1240965	16576	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	591	12	6	7	4.1	CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	1499	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	3779	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	536	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	CHEMBL434	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	DB01064	2078	47	None	-91	38	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	156014685	178322	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	CHEMBL4636111	178322	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651237	178322	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	155536173	172138	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4473349	172138	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155527926	171229	0	None	8709	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4460095	171229	0	None	8709	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	11714238	16577	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1240966	16577	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	11647002	15606	0	None	8	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2014.06.014
	CHEMBL1221681	15606	0	None	8	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2014.06.014
	164612026	185345	0	None	776	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	CHEMBL4860455	185345	0	None	776	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	56672271	66511	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835859	66511	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852407	66511	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	24901144	70300	0	None	1	5	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944691	70300	0	None	1	5	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	57393349	70504	0	None	3	2	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	523	11	4	5	6.2	C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1	10.1016/j.bmcl.2011.10.049
	CHEMBL1947151	70504	0	None	3	2	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	523	11	4	5	6.2	C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1	10.1016/j.bmcl.2011.10.049
	2419	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	5152	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	559	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	CHEMBL1263	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	DB00938	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	56672116	66335	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1814276	66335	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1851624	66335	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	10372836	102370	39	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3039518	102370	39	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	10372344	119020	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	675	12	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	CHEMBL3426687	119020	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	675	12	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	10327462	119021	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	709	12	6	8	6.4	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl	10.1021/jm501915g
	CHEMBL3426688	119021	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	709	12	6	8	6.4	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl	10.1021/jm501915g
	118737348	119024	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	705	13	6	9	5.8	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426691	119024	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	705	13	6	9	5.8	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	118737351	119028	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C	10.1021/jm501915g
	CHEMBL3426695	119028	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C	10.1021/jm501915g
	118737355	119035	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	5	8	5.5	CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	CHEMBL3426702	119035	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	5	8	5.5	CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	56943515	112417	0	None	7	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298213	112417	0	None	7	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	10173878	112432	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	459	10	5	6	4.2	CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298327	112432	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	459	10	5	6	4.2	CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	24901210	70299	0	None	125	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	497	11	5	6	4.1	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944690	70299	0	None	125	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	497	11	5	6	4.1	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1	10.1016/j.bmcl.2011.10.049
	24901347	70304	0	None	17	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	463	11	5	6	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944695	70304	0	None	17	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	463	11	5	6	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	24901413	70327	0	None	-3	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	CHEMBL1945032	70327	0	None	-3	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	2419	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	5152	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	559	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	CHEMBL1263	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	DB00938	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	156016062	178301	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4643148	178301	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651124	178301	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	2419	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	5152	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	559	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	CHEMBL1263	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	DB00938	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	56672271	66511	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835859	66511	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852407	66511	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	2419	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	559	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	CHEMBL1263	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	DB00938	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	2419	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	5152	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	559	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	CHEMBL1263	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	DB00938	3437	84	None	10	14	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	46832509	14180	0	None	50	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL

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Ligand source activities (1 row/activity)