Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	164617688	187927	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847536	187927	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028449	187927	0	None	416	2	Human	11.0	pEC50	=	11.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164622954	187971	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4871708	187971	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028726	187971	0	None	245	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164625303	187994	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4873082	187994	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028871	187994	0	None	316	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164617772	187929	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848793	187929	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028458	187929	0	None	173	2	Human	10.9	pEC50	=	10.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	368	7	5	5	2.6	CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164615126	187910	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854569	187910	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028293	187910	0	None	104	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156010908	177748	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4634131	177748	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651173	177748	0	None	2238	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164623230	187976	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865710	187976	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028744	187976	0	None	1479	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164618278	187932	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848018	187932	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028489	187932	0	None	389	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164615492	187915	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848704	187915	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028319	187915	0	None	120	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164623105	187973	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4862449	187973	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028738	187973	0	None	47	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164611794	187881	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4854261	187881	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028104	187881	0	None	131	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164612025	187883	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4860454	187883	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028117	187883	0	None	2454	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164618895	187940	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868938	187940	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028525	187940	0	None	95	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164610792	187874	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4855974	187874	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028040	187874	0	None	134	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	380	7	4	4	3.6	Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	11504295	2867	40	None	1047	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	4814	2867	40	None	1047	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	7543	2867	40	None	1047	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	CHEMBL605846	2867	40	None	1047	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	DB09080	2867	40	None	1047	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1021/acs.jmedchem.0c01195
	9957764	88265	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	503	11	6	6	3.6	COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL236039	88265	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	503	11	6	6	3.6	COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	11259765	85569	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	462	11	5	5	3.4	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	CHEMBL230486	85569	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	462	11	5	5	3.4	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	11621158	16508	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1242943	16508	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155517986	169629	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	169629	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155517986	169629	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4445289	169629	0	None	478630	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164621302	187956	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863282	187956	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028641	187956	0	None	120	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	164623918	187983	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872480	187983	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028793	187983	0	None	199	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	374	7	4	4	2.8	O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	44434130	88268	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	5	5	3.9	C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL236041	88268	0	None	-	1	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	5	5	3.9	C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	164615222	187912	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4857267	187912	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028301	187912	0	None	91	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164622827	187969	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868585	187969	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028721	187969	0	None	26	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	400	7	4	4	3.9	CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	11455274	16530	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	12	5	6	3.3	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243189	16530	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	12	5	6	3.3	CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	164624634	187990	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868684	187990	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028836	187990	0	None	131	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014115	177705	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4635163	177705	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650951	177705	0	None	58	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	11214499	85571	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	516	11	5	5	4.3	C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	CHEMBL230490	85571	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	516	11	5	5	4.3	C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	164608750	187864	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4846631	187864	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5027923	187864	0	None	181	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	156015148	177700	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4646881	177700	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650929	177700	0	None	208	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164620479	187949	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4863847	187949	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028596	187949	0	None	288	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	11249243	16527	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	511	12	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243158	16527	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	511	12	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	156015482	177667	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4641262	177667	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4650664	177667	0	None	204	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	164619360	187943	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4868763	187943	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028547	187943	0	None	371	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	370	7	4	4	3.0	CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164623544	187979	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4872653	187979	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028764	187979	0	None	2754	2	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	406	7	4	4	3.5	O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	164612078	187884	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4848617	187884	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028119	187884	0	None	64	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	8	4	5	2.9	COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014817	177719	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4642770	177719	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4650993	177719	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164617235	187924	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4848775	187924	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028422	187924	0	None	251	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	396	8	4	5	3.3	COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	156013777	177763	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4636255	177763	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651241	177763	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	10390417	167191	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	480	10	6	7	3.0	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL430361	167191	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	480	10	6	7	3.0	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	49864395	15446	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2010.06.136
	CHEMBL1221680	15446	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2010.06.136
	11477877	16553	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	517	12	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243348	16553	0	None	-	1	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	517	12	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	13121366	176871	0	None	457	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	370	7	4	5	2.8	CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4638864	176871	0	None	457	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	370	7	4	5	2.8	CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	164612262	187885	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4853372	187885	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028127	187885	0	None	190	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	164614743	187905	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4860764	187905	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028269	187905	0	None	134	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	156014962	177665	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4645203	177665	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4650644	177665	0	None	229	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	155536314	171599	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4473515	171599	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	155536314	171599	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4473515	171599	0	None	6025	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	164620585	187950	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4866766	187950	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028602	187950	0	None	616	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	382	7	5	5	3.0	CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	44434126	88267	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	519	11	6	6	4.3	CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL236040	88267	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	519	11	6	6	4.3	CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	10027868	144347	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	474	10	6	6	2.9	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL391006	144347	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	474	10	6	6	2.9	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	164618813	187939	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4865833	187939	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028523	187939	0	None	275	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	366	7	4	4	3.2	Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	164623433	187977	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL4870623	187977	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	CHEMBL5028756	187977	0	None	380	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.ejmech.2021.113697
	156014983	177745	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4644638	177745	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651152	177745	0	None	724	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	386	7	5	6	2.5	CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	11261001	16531	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	13	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243190	16531	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	525	13	5	6	2.9	C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	11489605	16538	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	541	13	5	7	2.9	COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243256	16538	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	541	13	5	7	2.9	COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	155533625	171301	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4469364	171301	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	366	7	4	4	3.3	CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155564766	174906	0	None	181	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4577508	174906	0	None	181	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	11489574	16535	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	14	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243222	16535	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	14	5	6	3.3	C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155536813	171630	0	None	263	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4473790	171630	0	None	263	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164624092	187986	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4865514	187986	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028807	187986	0	None	794	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	442	10	4	7	2.9	COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	2419	3394	80	None	17	6	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	5152	3394	80	None	17	6	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	559	3394	80	None	17	6	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	CHEMBL1263	3394	80	None	17	6	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	DB00938	3394	80	None	17	6	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2019.115178
	11699773	16522	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	569	12	6	7	3.6	Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243101	16522	0	None	-	1	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	569	12	6	7	3.6	Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	164626310	188000	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL4874945	188000	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	CHEMBL5028930	188000	0	None	346	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	356	7	4	4	2.6	O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1	10.1016/j.ejmech.2021.113697
	11398811	16541	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	555	14	5	7	3.3	CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	CHEMBL1243285	16541	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	555	14	5	7	3.3	CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1	10.1021/jm1005989
	155543358	174191	0	None	102	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4561253	174191	0	None	102	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	156015401	177686	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4645694	177686	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	CHEMBL4650809	177686	0	None	251	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1	10.1016/j.bmc.2019.115178
	156015798	177693	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4649233	177693	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	CHEMBL4650858	177693	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	400	8	4	6	2.8	COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1	10.1016/j.bmc.2019.115178
	44434125	145566	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	473	10	6	5	3.6	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL391946	145566	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	473	10	6	5	3.6	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	44237865	57908	0	None	-	1	Guinea pig	10.3	pEC50	=	10.3	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	500	11	6	5	3.9	O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682213	57908	0	None	-	1	Guinea pig	10.3	pEC50	=	10.3	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	500	11	6	5	3.9	O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	155557083	173959	0	None	724	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4556022	173959	0	None	724	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	354	7	5	5	2.2	O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	10389119	88312	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	451	10	6	5	3.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL236251	88312	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	451	10	6	5	3.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	155564340	174841	0	None	263	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	CHEMBL4576089	174841	0	None	263	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	493	11	5	5	4.9	CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C	10.1016/j.bmc.2018.10.043
	44434127	88165	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	509	10	6	5	3.8	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL235612	88165	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	509	10	6	5	3.8	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	3466	4063	38	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	37990	4063	38	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	CHEMBL1243407	4063	38	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	378	8	4	5	2.4	OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C	10.1021/jm1005989
	1499	2052	43	None	-72	36	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	3779	2052	43	None	-72	36	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	536	2052	43	None	-72	36	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	CHEMBL434	2052	43	None	-72	36	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	DB01064	2052	43	None	-72	36	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2019.115178
	11376125	16546	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	12	5	6	3.5	Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C	10.1021/jm1005989
	CHEMBL1243317	16546	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	539	12	5	6	3.5	Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C	10.1021/jm1005989
	164614249	187900	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4859591	187900	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028241	187900	0	None	295	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	10324803	89151	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	533	12	6	7	3.6	COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	CHEMBL237501	89151	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	533	12	6	7	3.6	COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1	10.1016/j.bmcl.2007.09.031
	10390752	145711	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	6	5	4.1	C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL392056	145711	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	487	10	6	5	4.1	C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	16049087	63737	0	None	125	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807817	63737	0	None	125	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	9892481	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	CHEMBL1940832	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.095
	90645347	112008	0	None	7	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298987	112008	0	None	7	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	578	12	6	7	5.6	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	9892481	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.069
	CHEMBL1940832	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2014.04.069
	9892481	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940832	69875	11	None	-3	4	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	435	12	6	6	3.0	O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	11420492	154649	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	492	10	5	5	3.8	C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	CHEMBL402501	154649	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	492	10	5	5	3.8	C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1021/jm1005989
	155564079	174828	0	None	97	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4575759	174828	0	None	97	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	11456127	16552	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	593	12	5	6	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243347	16552	0	None	-	1	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	593	12	5	6	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	44237667	57905	0	None	-	1	Guinea pig	10.2	pEC50	=	10.2	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	458	8	6	5	3.7	O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682210	57905	0	None	-	1	Guinea pig	10.2	pEC50	=	10.2	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	458	8	6	5	3.7	O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	2419	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	5152	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	559	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	CHEMBL1263	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	DB00938	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.09.031
	2419	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	5152	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	559	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	CHEMBL1263	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	DB00938	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2007.04.081
	2419	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	5152	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	559	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	CHEMBL1263	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	DB00938	3394	80	None	17	6	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm1005989
	45269924	193767	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction	ChEMBL	283	6	5	6	-0.1	CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1	10.1016/j.ejmech.2008.12.016
	CHEMBL552398	193767	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction	ChEMBL	283	6	5	6	-0.1	CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1	10.1016/j.ejmech.2008.12.016
	164615474	187914	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL4847767	187914	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	CHEMBL5028315	187914	0	None	61	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	4	3.5	CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.ejmech.2021.113697
	155548071	173167	0	None	131	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4536813	173167	0	None	131	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	338	7	4	4	2.5	O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	155567283	175387	0	None	588	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	CHEMBL4588479	175387	0	None	588	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	368	8	4	5	2.5	COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.bmc.2018.10.043
	155548668	173201	0	None	-	1	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4537644	173201	0	None	-	1	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	2419	3394	80	None	17	6	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	5152	3394	80	None	17	6	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	559	3394	80	None	17	6	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	CHEMBL1263	3394	80	None	17	6	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	DB00938	3394	80	None	17	6	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2018.10.043
	16049088	63738	0	None	100	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807818	63738	0	None	100	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	448	13	4	7	3.3	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	16049028	63739	0	None	50	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807819	63739	0	None	50	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	462	14	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	11592062	111952	0	None	25	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298325	111952	0	None	25	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	11169365	112007	0	None	22	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298986	112007	0	None	22	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	155513474	169162	0	None	83	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4438531	169162	0	None	83	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	478	8	4	4	5.1	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	164622775	187968	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL4867311	187968	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	CHEMBL5028718	187968	0	None	120226	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	428	10	4	7	2.5	COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC	10.1016/j.ejmech.2021.113697
	11504295	2867	40	None	1047	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	4814	2867	40	None	1047	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	7543	2867	40	None	1047	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	CHEMBL605846	2867	40	None	1047	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	DB09080	2867	40	None	1047	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1016/j.ejmech.2021.113697
	44237615	57907	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	486	10	6	5	3.5	O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682212	57907	0	None	-	1	Guinea pig	10.1	pEC50	=	10.1	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	486	10	6	5	3.5	O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	11707090	16518	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243068	16518	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	164623583	187981	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL4873280	187981	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	CHEMBL5028767	187981	0	None	316	2	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	352	7	4	4	2.8	Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1016/j.ejmech.2021.113697
	11247541	85523	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	434	11	5	5	2.6	O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1	10.1016/j.bmcl.2007.04.081
	CHEMBL230203	85523	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	434	11	5	5	2.6	O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1	10.1016/j.bmcl.2007.04.081
	44425580	85570	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	448	11	5	5	3.0	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	CHEMBL230487	85570	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP	ChEMBL	448	11	5	5	3.0	C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.04.081
	57334265	70499	0	None	-	1	Guinea pig	10.0	pEC50	=	10	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	538	13	4	8	3.4	COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC	10.1016/j.bmcl.2012.01.013
	CHEMBL1951067	70499	0	None	-	1	Guinea pig	10.0	pEC50	=	10	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	538	13	4	8	3.4	COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC	10.1016/j.bmcl.2012.01.013
	12065	621	21	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	45483813	621	21	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	CHEMBL579394	621	21	None	6	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	370	6	4	5	2.7	Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O	10.1016/j.bmcl.2009.10.013
	13345218	195535	0	None	8	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL568272	195535	0	None	8	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	372	6	5	6	2.1	CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	16049024	63740	0	None	79	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	498	13	4	7	4.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807820	63740	0	None	79	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	498	13	4	7	4.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	118737358	118547	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	13	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1021/jm501915g
	CHEMBL3426706	118547	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	13	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1021/jm501915g
	10239722	111953	0	None	11	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298326	111953	0	None	11	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1	10.1016/j.bmcl.2014.04.095
	66796015	111955	0	None	35	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298328	111955	0	None	35	3	Human	10.0	pEC50	=	10	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	474	11	6	7	3.2	NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	10180590	69873	0	None	707	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	CHEMBL1940830	69873	0	None	707	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	422	11	6	6	2.9	OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O	10.1016/j.bmcl.2011.11.072
	105	3392	84	None	-8	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	2083	3392	84	None	-8	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	558	3392	84	None	-8	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	CHEMBL714	3392	84	None	-8	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	DB01001	3392	84	None	-8	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis	ChEMBL	239	4	4	4	1.3	OCc1cc(ccc1O)C(CNC(C)(C)C)O	10.1021/acs.jmedchem.1c02006
	10392857	88217	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	552	11	7	7	2.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL235818	88217	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	552	11	7	7	2.2	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	3083544	462	46	None	-1	4	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2012.01.013
	4943	462	46	None	-1	4	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2012.01.013
	7479	462	46	None	-1	4	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2012.01.013
	CHEMBL1363	462	46	None	-1	4	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2012.01.013
	DB01274	462	46	None	-1	4	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2012.01.013
	16049026	63741	0	None	25	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	432	13	4	7	2.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807821	63741	0	None	25	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	432	13	4	7	2.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1	10.1016/j.bmcl.2011.05.097
	16049029	63742	0	None	25	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	482	13	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807822	63742	0	None	25	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	482	13	4	7	3.7	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1	10.1016/j.bmcl.2011.05.097
	10461973	118538	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	655	15	6	8	4.9	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426697	118538	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	655	15	6	8	4.9	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	9871386	111766	4	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3290999	111766	4	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.095
	90645344	111951	0	None	7	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	CHEMBL3298324	111951	0	None	7	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN	10.1016/j.bmcl.2014.04.095
	56943545	111957	0	None	28	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298330	111957	0	None	28	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	502	13	6	7	4.0	NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	11180293	112003	0	None	22	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298897	112003	0	None	22	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	543	12	6	8	3.1	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	46832232	14085	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1085837	14085	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	CHEMBL1198923	14085	0	None	39	3	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	467	16	4	6	4.5	OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O	10.1021/jm100326d
	10217757	111765	0	None	10	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290998	111765	0	None	10	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	497	12	5	6	5.2	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	9871386	111766	4	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	CHEMBL3290999	111766	4	None	8	4	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	521	10	5	6	5.5	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1	10.1016/j.bmcl.2014.04.069
	57398384	69876	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	459	10	6	6	3.2	O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2011.11.072
	CHEMBL1940833	69876	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay	ChEMBL	459	10	6	6	3.2	O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2011.11.072
	156015656	177758	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4639822	177758	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651230	177758	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	378	7	4	5	2.3	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1	10.1016/j.bmc.2019.115178
	53323515	57909	0	None	-	1	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	515	10	7	6	2.5	NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682214	57909	0	None	-	1	Guinea pig	9.9	pEC50	=	9.9	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	515	10	7	6	2.5	NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1	10.1016/j.bmcl.2010.12.096
	46938907	16515	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243035	16515	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	609	12	6	7	4.3	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	155524038	170314	0	None	120	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4454489	170314	0	None	120	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	414	8	4	4	4.2	O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	2419	3394	80	None	17	6	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	5152	3394	80	None	17	6	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	559	3394	80	None	17	6	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	CHEMBL1263	3394	80	None	17	6	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	DB00938	3394	80	None	17	6	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.ejmech.2021.113697
	156020412	177764	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4648525	177764	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651243	177764	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	446	8	4	5	4.3	CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	155550964	173368	0	None	575	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4541263	173368	0	None	575	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	352	8	4	4	2.9	O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	1499	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	3779	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	536	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	CHEMBL434	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	DB01064	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0101500
	1499	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	3779	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	536	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	CHEMBL434	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	DB01064	2052	43	None	-72	36	Human	9.8	pEC50	=	9.8	Functional	Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1021/jm0509445
	10394806	118539	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	681	12	6	8	5.3	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1	10.1021/jm501915g
	CHEMBL3426698	118539	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	681	12	6	8	5.3	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1	10.1021/jm501915g
	118737354	118542	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	703	12	6	8	5.8	Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426701	118542	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	703	12	6	8	5.8	Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	56943518	111956	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298329	111956	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	488	12	6	7	3.6	NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	56943546	111973	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298691	111973	0	None	25	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	518	14	6	8	3.2	NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	24901144	69971	0	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944691	69971	0	None	-1	5	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	10288976	66232	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835862	66232	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852543	66232	0	None	10	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	487	17	6	6	3.9	Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1	10.1016/j.bmc.2011.08.043
	9849126	12318	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL1185969	12318	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	CHEMBL443435	12318	0	None	-3	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	507	18	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1	10.1021/jm801016j
	9891927	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL446840	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483200	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL483201	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	9891927	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL446840	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483200	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL483201	183605	6	None	5	4	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	494	17	5	7	2.8	NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	155551133	173414	0	None	446	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	CHEMBL4542430	173414	0	None	446	2	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	340	7	4	5	1.9	O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1	10.1016/j.bmc.2018.10.043
	44434128	148595	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	489	10	7	6	3.3	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL394339	148595	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	489	10	7	6	3.3	C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	11534330	16512	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1243000	16512	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	575	12	6	7	3.6	CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	156020206	177757	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4648663	177757	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651226	177757	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1	10.1016/j.bmc.2019.115178
	156015463	177766	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4640925	177766	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	CHEMBL4651254	177766	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	482	8	4	5	4.6	CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2	10.1016/j.bmc.2019.115178
	1239	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	3410	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	3465	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	CHEMBL1256786	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	DB00983	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2011.01.043
	56658246	64151	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814277	64151	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	CHEMBL1814278	64151	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	525	17	5	8	2.9	O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.05.064
	24901413	69998	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	CHEMBL1945032	69998	0	None	3	4	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	15981386	63204	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr	ChEMBL	459	12	4	7	2.0	CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1	10.1016/j.bmcl.2011.04.135
	CHEMBL1800472	63204	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr	ChEMBL	459	12	4	7	2.0	CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1	10.1016/j.bmcl.2011.04.135
	56663238	63756	0	None	251	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	CHEMBL1807872	63756	0	None	251	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins	ChEMBL	465	13	5	7	2.8	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1	10.1016/j.bmcl.2011.05.097
	11857427	118534	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1	10.1021/jm501915g
	CHEMBL3426693	118534	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1	10.1021/jm501915g
	118737350	118535	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426694	118535	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	6	8	6.1	Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	1239	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3410	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	3465	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	CHEMBL1256786	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	DB00983	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.095
	16738927	70000	0	None	31	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1945034	70000	0	None	31	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	42625823	12555	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL1187371	12555	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	CHEMBL500782	12555	0	None	251	3	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	576	19	5	7	4.7	O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm801016j
	1239	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3410	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	3465	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	CHEMBL1256786	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	DB00983	1639	46	None	-1	5	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2014.04.069
	44237612	57906	0	None	4466	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682211	57906	0	None	4466	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	472	9	6	5	3.4	O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237613	57910	0	None	2754	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682215	57910	0	None	2754	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	502	10	6	6	3.4	COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237614	57911	0	None	31622	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682216	57911	0	None	31622	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	490	9	6	5	3.6	O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237669	57912	0	None	7943	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682217	57912	0	None	7943	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	540	9	6	5	4.7	O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmcl.2010.12.096
	44237666	57913	0	None	44668	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	CHEMBL1682218	57913	0	None	44668	2	Guinea pig	9.7	pEC50	=	9.7	Functional	Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation	ChEMBL	548	10	6	5	5.0	O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2010.12.096
	45483810	195458	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	CHEMBL567863	195458	0	None	3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation	ChEMBL	356	6	4	5	2.4	CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2	10.1016/j.bmcl.2009.10.013
	1499	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	3779	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	536	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	CHEMBL434	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	DB01064	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2013.11.030
	11577915	16416	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	591	12	6	7	4.1	CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1240965	16416	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	591	12	6	7	4.1	CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	1499	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	3779	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	536	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	CHEMBL434	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	DB01064	2052	43	None	-72	36	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2021.113697
	156014685	177761	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	CHEMBL4636111	177761	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651237	177761	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	358	7	5	6	1.7	O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1	10.1016/j.bmc.2019.115178
	155536173	171586	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	CHEMBL4473349	171586	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	442	8	4	4	4.9	CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12	10.1016/j.bmc.2018.10.043
	155527926	170677	0	None	8709	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	CHEMBL4460095	170677	0	None	8709	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	451	11	5	5	3.9	CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1	10.1016/j.bmc.2018.10.043
	11714238	16417	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1240966	16417	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	11647002	15447	0	None	8	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2014.06.014
	CHEMBL1221681	15447	0	None	8	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level	ChEMBL	400	7	4	6	3.1	O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1	10.1016/j.bmcl.2014.06.014
	164612026	184777	0	None	776	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	CHEMBL4860455	184777	0	None	776	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay	ChEMBL	237	4	3	4	1.3	CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1	10.1021/acs.jmedchem.0c01195
	56672271	66193	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835859	66193	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852407	66193	0	None	-1	4	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	24901144	69971	0	None	1	5	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944691	69971	0	None	1	5	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	481	11	5	6	3.6	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1	10.1016/j.bmcl.2011.10.049
	57393349	70174	0	None	3	2	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	523	11	4	5	6.2	C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1	10.1016/j.bmcl.2011.10.049
	CHEMBL1947151	70174	0	None	3	2	Guinea pig	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	523	11	4	5	6.2	C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1	10.1016/j.bmcl.2011.10.049
	2419	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	5152	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	559	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	CHEMBL1263	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	DB00938	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.05.064
	56672116	66018	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1814276	66018	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	CHEMBL1851624	66018	0	None	316	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	570	19	5	8	2.4	NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O	10.1016/j.bmc.2011.05.064
	10372836	101912	34	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3039518	101912	34	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	739	13	6	9	6.4	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	10372344	118528	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	675	12	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	CHEMBL3426687	118528	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	675	12	6	8	5.8	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	10327462	118529	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	709	12	6	8	6.4	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl	10.1021/jm501915g
	CHEMBL3426688	118529	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	709	12	6	8	6.4	O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl	10.1021/jm501915g
	118737348	118532	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	705	13	6	9	5.8	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426691	118532	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	705	13	6	9	5.8	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	118737351	118536	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C	10.1021/jm501915g
	CHEMBL3426695	118536	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C	10.1021/jm501915g
	118737355	118543	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	5	8	5.5	CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	CHEMBL3426702	118543	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	689	12	5	8	5.5	CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1	10.1021/jm501915g
	56943515	111939	0	None	7	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298213	111939	0	None	7	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	478	13	6	7	3.7	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1	10.1016/j.bmcl.2014.04.095
	10173878	111954	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	459	10	5	6	4.2	CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298327	111954	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	459	10	5	6	4.2	CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
	24901210	69970	0	None	125	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	497	11	5	6	4.1	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944690	69970	0	None	125	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	497	11	5	6	4.1	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1	10.1016/j.bmcl.2011.10.049
	24901347	69975	0	None	17	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	463	11	5	6	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1944695	69975	0	None	17	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	463	11	5	6	3.5	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1	10.1016/j.bmcl.2011.10.049
	24901413	69998	0	None	-3	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	CHEMBL1945032	69998	0	None	-3	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry	ChEMBL	516	11	6	6	4.3	Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12	10.1016/j.bmcl.2011.10.049
	2419	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	5152	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	559	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	CHEMBL1263	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	DB00938	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm401532g
	156016062	177740	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4643148	177740	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	CHEMBL4651124	177740	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	356	8	4	5	2.4	O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1	10.1016/j.bmc.2019.115178
	2419	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	5152	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	559	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	CHEMBL1263	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	DB00938	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmc.2011.08.043
	56672271	66193	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1835859	66193	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	CHEMBL1852407	66193	0	None	1	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation	ChEMBL	530	19	7	7	2.7	NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1016/j.bmc.2011.08.043
	2419	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	5152	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	559	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	CHEMBL1263	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	DB00938	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm801016j
	2419	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	5152	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	559	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	CHEMBL1263	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	DB00938	3394	80	None	17	6	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1021/jm100326d
	46832509	14082	0	None	50	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1085399	14082	0	None	50	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	CHEMBL1198908	14082	0	None	50	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins	ChEMBL	510	18	5	8	2.7	CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1	10.1021/jm100326d
	10006800	88269	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	517	12	6	6	3.6	COc1cccc(CCNC(=O)c2cc3cc(C[C@@H](C)NC[C@H](O)c4ccc(O)c(CO)c4)ccc3[nH]2)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL236042	88269	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	517	12	6	6	3.6	COc1cccc(CCNC(=O)c2cc3cc(C[C@@H](C)NC[C@H](O)c4ccc(O)c(CO)c4)ccc3[nH]2)c1	10.1016/j.bmcl.2007.09.031
	10256921	144750	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	547	13	6	7	4.0	CC[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(OC)cccc3OC)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	CHEMBL391308	144750	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels	ChEMBL	547	13	6	7	4.0	CC[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(OC)cccc3OC)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1	10.1016/j.bmcl.2007.09.031
	11505444	16418	13	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2cccc(-c3ccc(O)cc3)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	CHEMBL1240967	16418	13	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	ChEMBL	617	13	6	7	4.6	CC(C)(Cc1cccc(CC(=O)NCc2cccc(-c3ccc(O)cc3)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1	10.1021/jm1005989
	11625619	77251	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assayAgonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assay	ChEMBL	406	6	4	4	3.5	CCc1cc2c(cc1CC)CC(C)(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C2	10.1016/j.bmcl.2012.07.096
	CHEMBL2088201	77251	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assayAgonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assay	ChEMBL	406	6	4	4	3.5	CCc1cc2c(cc1CC)CC(C)(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C2	10.1016/j.bmcl.2012.07.096
	16735257	85290	0	None	812	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay	ChEMBL	317	7	4	5	2.4	COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1	10.1016/j.bmc.2009.11.062
	CHEMBL228992	85290	0	None	812	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay	ChEMBL	317	7	4	5	2.4	COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1	10.1016/j.bmc.2009.11.062
	688468	141788	7	None	346	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay	ChEMBL	303	6	5	5	2.1	C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1	10.1016/j.bmc.2009.11.062
	CHEMBL388570	141788	7	None	346	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay	ChEMBL	303	6	5	5	2.1	C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1	10.1016/j.bmc.2009.11.062
	16735257	85290	0	None	812	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	317	7	4	5	2.4	COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1	10.1016/j.bmc.2013.11.030
	CHEMBL228992	85290	0	None	812	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL	317	7	4	5	2.4	COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1	10.1016/j.bmc.2013.11.030
	155543518	174416	0	None	794	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	457	9	5	5	3.7	O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1	10.1016/j.bmc.2018.10.043
	CHEMBL4566727	174416	0	None	794	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	457	9	5	5	3.7	O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1	10.1016/j.bmc.2018.10.043
	1239	1639	46	None	-1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3410	1639	46	None	-1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3465	1639	46	None	-1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	CHEMBL1256786	1639	46	None	-1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	DB00983	1639	46	None	-1	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.05.064
	3083544	462	46	None	-1	4	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.08.043
	4943	462	46	None	-1	4	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.08.043
	7479	462	46	None	-1	4	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.08.043
	CHEMBL1363	462	46	None	-1	4	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.08.043
	DB01274	462	46	None	-1	4	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmc.2011.08.043
	24900685	69999	0	None	3	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1	10.1016/j.bmcl.2011.10.049
	CHEMBL1945033	69999	0	None	3	5	Guinea pig	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction	ChEMBL	464	11	5	7	2.9	O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1	10.1016/j.bmcl.2011.10.049
	3083544	462	46	None	1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2013.11.028
	4943	462	46	None	1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2013.11.028
	7479	462	46	None	1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2013.11.028
	CHEMBL1363	462	46	None	1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2013.11.028
	DB01274	462	46	None	1	4	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)	ChEMBL	344	9	4	5	2.2	O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O	10.1016/j.bmcl.2013.11.028
	118737352	118537	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	CHEMBL3426696	118537	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting	ChEMBL	719	13	6	9	6.1	COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12	10.1021/jm501915g
	1499	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	1499	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	3779	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	3779	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	536	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	536	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	CHEMBL434	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	CHEMBL434	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	DB01064	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.bmc.2018.10.043
	DB01064	2052	43	None	-72	36	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1016/j.ejmech.2018.04.041
	2419	3394	80	None	17	6	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	5152	3394	80	None	17	6	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	559	3394	80	None	17	6	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	CHEMBL1263	3394	80	None	17	6	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	DB00938	3394	80	None	17	6	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1016/j.bmcl.2014.04.095
	56943485	111998	0	None	12	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	544	12	5	8	3.6	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298831	111998	0	None	12	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay	ChEMBL	544	12	5	8	3.6	O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2014.04.095
	11592062	111952	0	None	25	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1	10.1016/j.bmcl.2014.04.095
	CHEMBL3298325	111952	0	None	25	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assay	ChEMBL	550	11	6	7	5.0	COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1

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Ligand source activities (1 row/activity)