Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10456166	119115	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL346692	119115	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL4285942	119115	0	None	-	1	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	52937876	60831	0	None	489	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL1765633	60831	0	None	489	2	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	24866114	178101	0	None	223	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	467	7	1	6	4.4	CCCN(CCN1CCN(c2cccc(Cl)c2Cl)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	CHEMBL468017	178101	0	None	223	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	467	7	1	6	4.4	CCCN(CCN1CCN(c2cccc(Cl)c2Cl)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	24754400	154051	0	None	19	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	423	8	1	5	3.8	CCCN(CCN1CCN(c2ccccc2OC)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	CHEMBL399164	154051	0	None	19	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	423	8	1	5	3.8	CCCN(CCN1CCN(c2ccccc2OC)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	24936081	178051	0	None	234	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	CHEMBL467540	178051	0	None	234	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	24866612	189019	0	None	72	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL514885	189019	0	None	72	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	2	3198	19	None	2	7	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	54562	3198	19	None	2	7	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	CHEMBL240773	3198	19	None	2	7	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	56941366	105206	0	None	158	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	491	8	2	7	4.5	CCCN(CCN1CCN(c2ccc(-c3cccc(O)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	CHEMBL3125990	105206	0	None	158	2	Human	10.0	pEC50	=	10	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	491	8	2	7	4.5	CCCN(CCN1CCN(c2ccc(-c3cccc(O)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	681	1432	65	None	-2	12	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	940	1432	65	None	-2	12	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	947	1432	65	None	-2	12	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	CHEMBL59	1432	65	None	-2	12	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	DB00988	1432	65	None	-2	12	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	24742011	93865	0	None	18	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	CHEMBL250552	93865	0	None	18	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	128	149	9	None	9	3	Human	9.9	pEC50	=	9.9	Functional	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	172267	149	9	None	9	3	Human	9.9	pEC50	=	9.9	Functional	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	CHEMBL273273	149	9	None	9	3	Human	9.9	pEC50	=	9.9	Functional	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	119570	3098	90	None	1	7	Rat	9.7	pEC50	=	9.7	Functional	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	2233	3098	90	None	1	7	Rat	9.7	pEC50	=	9.7	Functional	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	953	3098	90	None	1	7	Rat	9.7	pEC50	=	9.7	Functional	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	CHEMBL301265	3098	90	None	1	7	Rat	9.7	pEC50	=	9.7	Functional	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	DB00413	3098	90	None	1	7	Rat	9.7	pEC50	=	9.7	Functional	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	17449900	138999	12	None	1	3	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL379602	138999	12	None	1	3	Human	9.7	pEC50	=	9.7	Functional	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	52941006	16903	0	None	208	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2c(O)cccc2C1	10.1016/j.bmc.2010.06.025
	CHEMBL1254947	16903	0	None	208	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2c(O)cccc2C1	10.1016/j.bmc.2010.06.025
	60148494	80433	0	None	446	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152747	80433	0	None	446	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	60165801	80432	0	None	446	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)C1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	CHEMBL2152746	80432	0	None	446	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)C1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	85470564	156269	0	None	37	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071240	156269	0	None	37	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	137633863	156072	0	None	12	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069145	156072	0	None	12	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	137633863	156072	0	None	12	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069145	156072	0	None	12	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	132578416	173224	0	None	-1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	383	9	3	4	4.8	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4538230	173224	0	None	-1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	383	9	3	4	4.8	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2016.08.021
	25256816	181016	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477206	181016	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	5311346	202444	22	None	467	5	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	CHEMBL1256778	202444	22	None	467	5	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	CHEMBL70565	202444	22	None	467	5	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	9888555	165041	11	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	CHEMBL424294	165041	11	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	2	3198	19	None	2	7	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	54562	3198	19	None	2	7	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	CHEMBL240773	3198	19	None	2	7	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	137651936	156838	0	None	5	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4078348	156838	0	None	5	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137651936	156838	0	None	5	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4078348	156838	0	None	5	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137660837	158522	0	None	4	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4097330	158522	0	None	4	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137660837	158522	0	None	4	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4097330	158522	0	None	4	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	45486325	196733	0	None	158	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2ccnc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL577073	196733	0	None	158	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2ccnc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	45486330	196105	0	None	173	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL571992	196105	0	None	173	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	45486328	195676	0	None	25	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2cccc3ncccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL569107	195676	0	None	25	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2cccc3ncccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	71459659	83407	0	None	3	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	534	16	2	4	7.7	CCCN(CCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL2206264	83407	0	None	3	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	534	16	2	4	7.7	CCCN(CCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	11957566	183	20	None	1	4	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	1219	183	20	None	1	4	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	3296	183	20	None	1	4	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	950	183	20	None	1	4	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	CHEMBL285755	183	20	None	1	4	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	60148495	80441	0	None	125	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152755	80441	0	None	125	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	11299620	96822	2	None	64	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL269004	96822	2	None	64	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	10178704	49376	1	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm070860r
	CHEMBL156639	49376	1	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm070860r
	14465382	156428	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	386	7	2	3	6.2	CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	CHEMBL4073068	156428	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	386	7	2	3	6.2	CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	45140376	198964	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm901618d
	CHEMBL599635	198964	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm901618d
	155522454	170138	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	403	10	2	6	4.4	CCCN(CCCCCc1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4452046	170138	0	None	2	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	403	10	2	6	4.4	CCCN(CCCCCc1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	119570	3098	90	None	-1	7	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	2233	3098	90	None	-1	7	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	953	3098	90	None	-1	7	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	CHEMBL301265	3098	90	None	-1	7	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	DB00413	3098	90	None	-1	7	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	45486330	196105	0	None	173	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL571992	196105	0	None	173	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	45486330	196105	0	None	173	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	CHEMBL571992	196105	0	None	173	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	127038171	136387	0	None	46	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742140	136387	0	None	46	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742430	136387	0	None	46	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	137460109	190779	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS bindingAgonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS binding	ChEMBL	482	7	2	4	5.4	CCCN(CCN1CCN(c2ccc3c(c2)[nH]c2ccccc23)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5192367	190779	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS bindingAgonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS binding	ChEMBL	482	7	2	4	5.4	CCCN(CCN1CCN(c2ccc3c(c2)[nH]c2ccccc23)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.ejmech.2022.114378
	60148496	80438	0	None	100	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2c[nH]c3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152752	80438	0	None	100	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2c[nH]c3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	681	1432	65	None	-2	12	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	940	1432	65	None	-2	12	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	947	1432	65	None	-2	12	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	CHEMBL59	1432	65	None	-2	12	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	DB00988	1432	65	None	-2	12	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	85470564	156269	0	None	37	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071240	156269	0	None	37	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466573	157978	0	None	16	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4091498	157978	0	None	16	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466716	160444	0	None	1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099236	160444	0	None	1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116199	160444	0	None	1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	85469680	156162	0	None	5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156162	0	None	5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	71459660	83408	0	None	-2	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	548	17	2	4	8.1	CCCN(CCCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL2206265	83408	0	None	-2	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	548	17	2	4	8.1	CCCN(CCCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	11957566	183	20	None	1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	1219	183	20	None	1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	3296	183	20	None	1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	950	183	20	None	1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	CHEMBL285755	183	20	None	1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	44427827	92830	0	None	15	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL244990	92830	0	None	15	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	119570	3098	90	None	-1	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	2233	3098	90	None	-1	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	953	3098	90	None	-1	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	CHEMBL301265	3098	90	None	-1	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	DB00413	3098	90	None	-1	7	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	57242	3196	16	None	9	4	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	954	3196	16	None	9	4	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	CHEMBL155731	3196	16	None	9	4	Human	9.0	pEC50	=	9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	85469680	156162	0	None	5	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156162	0	None	5	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158036	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158036	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158036	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	CHEMBL4092052	158036	0	None	3	2	Human	9.0	pEC50	=	9	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	16038360	16773	0	None	104	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2ccc(O)cc2C1	10.1016/j.bmc.2010.06.025
	CHEMBL1253770	16773	0	None	104	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2ccc(O)cc2C1	10.1016/j.bmc.2010.06.025
	10411237	116966	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL339960	116966	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL4287055	116966	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	137660062	158827	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	370	7	1	2	6.5	CCCCCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	CHEMBL4100634	158827	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	370	7	1	2	6.5	CCCCCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	10368423	97465	0	None	-	1	Green monkey	8.9	pEC50	=	8.9	Functional	Effective concentration for Dopamine receptor D3 was determinedEffective concentration for Dopamine receptor D3 was determined	ChEMBL	493	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)cc2)CC1	10.1021/jm030836n
	CHEMBL27254	97465	0	None	-	1	Green monkey	8.9	pEC50	=	8.9	Functional	Effective concentration for Dopamine receptor D3 was determinedEffective concentration for Dopamine receptor D3 was determined	ChEMBL	493	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)cc2)CC1	10.1021/jm030836n
	155531663	171093	0	None	7	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1cc(O)ccc1O)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4466245	171093	0	None	7	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1cc(O)ccc1O)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	45273211	193944	0	None	33	2	Human	8.9	pEC50	=	8.9	Functional	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	7	2	4	3.9	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2009.04.031
	CHEMBL556269	193944	0	None	33	2	Human	8.9	pEC50	=	8.9	Functional	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	7	2	4	3.9	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2009.04.031
	128	149	9	None	9	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	172267	149	9	None	9	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	CHEMBL273273	149	9	None	9	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	60148497	80425	0	None	2	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	7	2	6	3.6	CCCN(CCN1CCN(c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152633	80425	0	None	2	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	7	2	6	3.6	CCCN(CCN1CCN(c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	2	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	54562	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	CHEMBL240773	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	90467024	157135	0	None	10	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157135	0	None	10	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	2	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	54562	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	CHEMBL240773	3198	19	None	2	7	Human	8.9	pEC50	=	8.9	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	10476504	33253	1	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL142020	33253	1	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	127037825	136383	0	None	2	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3740041	136383	0	None	2	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742426	136383	0	None	2	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	24759792	183816	0	None	190	2	Human	8.9	pEC50	=	8.9	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	286	2	1	3	2.0	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CNC4=O	10.1016/j.bmcl.2009.03.015
	CHEMBL484598	183816	0	None	190	2	Human	8.9	pEC50	=	8.9	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	286	2	1	3	2.0	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CNC4=O	10.1016/j.bmcl.2009.03.015
	90467024	157135	0	None	10	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157135	0	None	10	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	60194424	80011	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	511	9	2	7	4.3	CCCN(CC[C@H]1CC[C@H](NS(=O)(=O)c2cccnc2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	CHEMBL2146499	80011	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	511	9	2	7	4.3	CCCN(CC[C@H]1CC[C@H](NS(=O)(=O)c2cccnc2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	119570	3098	90	None	-1	7	Human	8.8	pEC50	=	8.8	Functional	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	2233	3098	90	None	-1	7	Human	8.8	pEC50	=	8.8	Functional	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	953	3098	90	None	-1	7	Human	8.8	pEC50	=	8.8	Functional	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	CHEMBL301265	3098	90	None	-1	7	Human	8.8	pEC50	=	8.8	Functional	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	DB00413	3098	90	None	-1	7	Human	8.8	pEC50	=	8.8	Functional	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	10092819	16579	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	CHEMBL124444	16579	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	24866612	189019	0	None	72	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL514885	189019	0	None	72	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	53361666	190017	0	None	2	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	466	7	2	8	3.4	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5181007	190017	0	None	2	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	466	7	2	8	3.4	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	45140377	198965	0	None	2	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2c(O)cccc2C1	10.1021/jm901618d
	CHEMBL599636	198965	0	None	2	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2c(O)cccc2C1	10.1021/jm901618d
	137660417	158597	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	158597	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	53475319	83088	7	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrsAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs	ChEMBL	478	8	3	6	4.2	CCCN(CC[C@]1(O)C[C@H](NC(=O)c2ccc3ccccc3c2)C1)[C@H]1CCc2nc(N)sc2C1	10.1021/ml200100t
	CHEMBL2203406	83088	7	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrsAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs	ChEMBL	478	8	3	6	4.2	CCCN(CC[C@]1(O)C[C@H](NC(=O)c2ccc3ccccc3c2)C1)[C@H]1CCc2nc(N)sc2C1	10.1021/ml200100t
	2	3198	19	None	-4	7	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	54562	3198	19	None	-4	7	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	CHEMBL240773	3198	19	None	-4	7	Rat	8.8	pEC50	=	8.8	Functional	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	2	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	54562	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	CHEMBL240773	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	2	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	54562	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	CHEMBL240773	3198	19	None	2	7	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	3038495	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	7625	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	CHEMBL25236	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	3038495	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	7625	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	CHEMBL25236	699	30	None	-8	7	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	25071384	111276	0	None	251	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287397	111276	0	None	251	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	25071384	111276	0	None	251	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287397	111276	0	None	251	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	2	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3198	19	None	2	7	Human	8.7	pEC50	=	8.7	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3198	19	None	2	7	Human	8.0	pEC50	=	8	Functional	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	54562	3198	19	None	2	7	Human	8.0	pEC50	=	8	Functional	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	CHEMBL240773	3198	19	None	2	7	Human	8.0	pEC50	=	8	Functional	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	16078	1330	19	None	-1	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	2424	1330	19	None	-1	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	4109	1330	19	None	-1	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	CHEMBL465	1330	19	None	-1	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	DB00470	1330	19	None	-1	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	2402	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	5095	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	7295	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	CHEMBL589	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	DB00268	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	2402	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	5095	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	7295	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	CHEMBL589	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	DB00268	3306	58	None	3	7	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	127047458	139192	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	419	7	1	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3798334	139192	0	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	419	7	1	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	681	1432	65	None	-2	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	940	1432	65	None	-2	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	947	1432	65	None	-2	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	CHEMBL59	1432	65	None	-2	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	DB00988	1432	65	None	-2	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	127037828	136386	0	None	30	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3740778	136386	0	None	30	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742429	136386	0	None	30	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	77461254	190620	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	477	8	1	8	3.6	CCCN(CCN1CCN(c2ccc(-c3ccccn3)nc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5189785	190620	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	477	8	1	8	3.6	CCCN(CCN1CCN(c2ccc(-c3ccccn3)nc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	164609493	183844	0	None	-10	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
	CHEMBL4846380	183844	0	None	-10	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
	168292954	192385	0	None	-7	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5202592	192385	0	None	-7	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222660	192385	0	None	-7	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	168295541	192428	0	None	-125	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5208845	192428	0	None	-125	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222926	192428	0	None	-125	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	90467323	158999	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4102620	158999	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	122181332	121346	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590083	121346	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	90467022	155367	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4C(F)(F)F)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4060896	155367	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4C(F)(F)F)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	127045794	139565	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3797771	139565	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800680	139565	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	127046015	139569	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	CHEMBL3799465	139569	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	CHEMBL3800684	139569	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	25072635	111278	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	CHEMBL3287399	111278	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	90467323	158999	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4102620	158999	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	11706497	77797	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	CHEMBL210461	77797	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	25072635	111278	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	CHEMBL3287399	111278	0	None	3	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	122181332	121346	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590083	121346	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	164619170	185009	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185009	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164619170	185009	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185009	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	25071692	111284	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287405	111284	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	90467322	156256	0	None	-6	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156256	0	None	-6	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	25071692	111284	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287405	111284	0	None	9	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	155516042	175709	0	None	794	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4443039	175709	0	None	794	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4595150	175709	0	None	794	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	164628178	185755	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	185755	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164628178	185755	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	185755	0	None	-10	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	90467172	156341	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4072140	156341	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90467317	155238	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.1	O=C(NCCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4059573	155238	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.1	O=C(NCCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	168295528	192419	0	None	-707	10	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	192419	0	None	-707	10	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	192419	0	None	-707	10	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	164628178	185755	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	185755	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164628178	185755	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	185755	0	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	9828632	99595	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	535	6	1	4	5.5	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL287198	99595	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	535	6	1	4	5.5	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	90467173	157641	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	443	8	1	4	5.4	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4087889	157641	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	443	8	1	4	5.4	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	44443903	153532	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	219	3	1	3	2.0	C=CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL398480	153532	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	219	3	1	3	2.0	C=CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	168294449	192406	0	None	-50	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	CHEMBL5204599	192406	0	None	-50	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222793	192406	0	None	-50	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	85469680	156162	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156162	0	None	5	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158036	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158036	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466425	158755	0	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	158755	0	None	10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	90467319	160477	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4095588	160477	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116454	160477	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	127045797	139568	0	None	21	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	CHEMBL3798372	139568	0	None	21	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	CHEMBL3800683	139568	0	None	21	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	90466574	158036	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158036	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	127047310	139532	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	433	8	1	5	4.5	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800489	139532	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	433	8	1	5	4.5	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	145988474	166587	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	379	7	2	5	2.8	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(C#N)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4290759	166587	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	379	7	2	5	2.8	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(C#N)cc1)CC2	10.1021/acsmedchemlett.8b00229
	154703875	175864	1	None	6	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4586582	175864	1	None	6	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596341	175864	1	None	6	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL5077114	212701	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.1c00611
	136056636	111283	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287404	111283	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90467021	156117	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156117	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	136056636	111283	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287404	111283	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90467021	156117	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156117	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	164609729	184505	0	None	-2	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4856059	184505	0	None	-2	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	164612037	184785	0	None	-2	12	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	CHEMBL4860528	184785	0	None	-2	12	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	90466864	158112	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4092900	158112	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90467171	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	90467171	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	160589	0	None	-1	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	11581443	95941	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	367	8	1	4	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1021/jm050729o
	CHEMBL26188	95941	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	367	8	1	4	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1021/jm050729o
	CHEMBL5089655	213436	0	None	63	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		N#CC(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.1c00611
	164616851	184357	0	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4853772	184357	0	None	-1	4	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	137658100	159057	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4103339	159057	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	44309775	102192	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	CHEMBL304605	102192	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	44309775	102192	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1016/s0960-894x(03)00389-5
	CHEMBL304605	102192	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1016/s0960-894x(03)00389-5
	154705015	175930	1	None	91	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4454380	175930	1	None	91	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596929	175930	1	None	91	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	25093832	155327	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155327	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467171	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	11678172	77663	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	CHEMBL209876	77663	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	90467171	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4079093	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4117318	160589	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	25093832	155327	0	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155327	0	None	-2	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467021	156117	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156117	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	25072941	155921	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4067439	155921	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	11510684	98188	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	CHEMBL277301	98188	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	2	3198	19	None	2	7	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	54562	3198	19	None	2	7	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	CHEMBL240773	3198	19	None	2	7	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	25072002	155561	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063235	155561	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	25072941	155921	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4067439	155921	0	None	-1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467024	157135	0	None	10	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157135	0	None	10	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	25072002	155561	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063235	155561	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	127046755	139562	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3798943	139562	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800677	139562	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	2402	3306	58	None	3	7	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	5095	3306	58	None	3	7	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	7295	3306	58	None	3	7	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	CHEMBL589	3306	58	None	3	7	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	DB00268	3306	58	None	3	7	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	242	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	34	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	CHEMBL1112	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	DB01238	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	242	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	34	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL1112	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB01238	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	90466867	155758	0	None	5	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4065510	155758	0	None	5	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	168281746	192270	0	None	-758	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	CHEMBL5184911	192270	0	None	-758	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221974	192270	0	None	-758	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	44436605	148519	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL394292	148519	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	44400674	124656	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL364516	124656	0	None	-1	2	Human	8.7	pEC50	=	8.7	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	681	1432	65	None	-2	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	940	1432	65	None	-2	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	947	1432	65	None	-2	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	CHEMBL59	1432	65	None	-2	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	DB00988	1432	65	None	-2	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	44436600	91356	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241212	91356	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	90466571	158838	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	458	8	2	5	3.8	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4100735	158838	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	458	8	2	5	3.8	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	25139181	183750	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	CHEMBL484358	183750	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	11316847	69989	0	None	6	2	Human	8.7	pEC50	=	8.7	Functional	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm049465g
	CHEMBL194493	69989	0	None	6	2	Human	8.7	pEC50	=	8.7	Functional	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm049465g
	15389743	183817	0	None	1	3	Human	8.6	pEC50	=	8.6	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	274	3	1	3	1.9	CCCN1CCO[C@@H]2c3cc(C(N)=O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.03.015
	CHEMBL484599	183817	0	None	1	3	Human	8.6	pEC50	=	8.6	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	274	3	1	3	1.9	CCCN1CCO[C@@H]2c3cc(C(N)=O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.03.015
	24805287	184181	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	2	0	4	2.5	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)COC4=O	10.1016/j.bmcl.2009.03.015
	CHEMBL485128	184181	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	2	0	4	2.5	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)COC4=O	10.1016/j.bmcl.2009.03.015
	90466425	158755	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	158755	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	54580906	61261	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771109	61261	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	90466425	158755	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	158755	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	2	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	54562	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	CHEMBL240773	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	2	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	54562	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	CHEMBL240773	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	122181330	121344	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590081	121344	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	90466717	156356	0	None	5	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4072282	156356	0	None	5	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	2	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	54562	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	CHEMBL240773	3198	19	None	2	7	Human	8.6	pEC50	=	8.6	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	155525527	170491	0	None	8	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4457171	170491	0	None	8	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	90466717	156356	0	None	5	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4072282	156356	0	None	5	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	3038495	699	30	None	-8	7	Human	8.6	pEC50	=	8.6	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	7625	699	30	None	-8	7	Human	8.6	pEC50	=	8.6	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	CHEMBL25236	699	30	None	-8	7	Human	8.6	pEC50	=	8.6	Functional	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	46893146	61263	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771110	61263	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	10084583	104286	3	None	9	3	Human	8.6	pEC50	=	8.6	Functional	Effective concentration required for agonistic activity against human Dopamine receptor D3Effective concentration required for agonistic activity against human Dopamine receptor D3	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	CHEMBL310867	104286	3	None	9	3	Human	8.6	pEC50	=	8.6	Functional	Effective concentration required for agonistic activity against human Dopamine receptor D3Effective concentration required for agonistic activity against human Dopamine receptor D3	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	2	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	54562	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	CHEMBL240773	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	44588497	175052	0	None	3	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)[C@H]1CCc2ccc(O)cc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL458088	175052	0	None	3	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)[C@H]1CCc2ccc(O)cc2C1	10.1016/j.ejmech.2022.114378
	242	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	34	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	CHEMBL1112	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	DB01238	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	242	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	34	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL1112	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB01238	467	117	None	-5	12	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	90466867	155758	0	None	5	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4065510	155758	0	None	5	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	44438230	93111	3	None	-9	2	Human	7.7	pEC50	=	7.7	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	2	2	4.6	Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246439	93111	3	None	-9	2	Human	7.7	pEC50	=	7.7	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	2	2	4.6	Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2006.10.076
	155563589	174736	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	401	9	2	6	4.5	CCCN(CCC/C=C/c1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4573578	174736	0	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	401	9	2	6	4.5	CCCN(CCC/C=C/c1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	127046238	139144	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)OC1CCCc2ccccc21	10.1039/C5MD00590F
	CHEMBL3798010	139144	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)OC1CCCc2ccccc21	10.1039/C5MD00590F
	11596603	9826	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	405	7	1	3	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm050729o
	CHEMBL114541	9826	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	405	7	1	3	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm050729o
	127046753	139561	0	None	15	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3799147	139561	0	None	15	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800675	139561	0	None	15	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	137660417	158597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	158597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	42625290	55938	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL1627316	55938	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	137660417	158597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	158597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	164622330	185270	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4867962	185270	0	None	-9	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	162665657	181784	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	427	7	1	4	4.8	O=C(NC/C=C/CN1CCN(c2ccccc2)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4785109	181784	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	427	7	1	4	4.8	O=C(NC/C=C/CN1CCN(c2ccccc2)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	164614549	184350	0	None	-1	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	CHEMBL4853668	184350	0	None	-1	4	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	90467322	156256	0	None	-6	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156256	0	None	-6	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	44438197	152726	2	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL397770	152726	2	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	90467322	156256	0	None	-6	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156256	0	None	-6	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	11307083	63209	0	None	6	2	Human	7.6	pEC50	=	7.6	Functional	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm049465g
	CHEMBL180060	63209	0	None	6	2	Human	7.6	pEC50	=	7.6	Functional	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm049465g
	90467170	160595	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4063681	160595	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117347	160595	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	44438228	93110	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	4	1	2	5.0	COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246438	93110	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	4	1	2	5.0	COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	2	3198	19	None	2	7	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	54562	3198	19	None	2	7	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	CHEMBL240773	3198	19	None	2	7	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	127045793	139564	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3798841	139564	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800679	139564	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL5073754	212524	0	None	41	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		CN(C)C(=O)C(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.1c00611
	137659303	158745	0	None	9	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4099711	158745	0	None	9	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	164608815	183862	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
	CHEMBL4846638	183862	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
	137659303	158745	0	None	9	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4099711	158745	0	None	9	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	15006491	4477	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL102463	4477	2	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	15232477	168853	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL442535	168853	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	25072633	158663	0	None	-7	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098803	158663	0	None	-7	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	164611757	184310	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
	CHEMBL4853107	184310	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
	168294767	192407	0	None	-562	11	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192407	0	None	-562	11	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192407	0	None	-562	11	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	25072633	158663	0	None	-7	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098803	158663	0	None	-7	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	154726381	175943	1	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4522558	175943	1	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597048	175943	1	None	1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	168273640	192193	0	None	-4	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5176229	192193	0	None	-4	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221444	192193	0	None	-4	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	3038495	699	30	None	-5	7	Green monkey	8.5	pEC50	=	8.5	Functional	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	7625	699	30	None	-5	7	Green monkey	8.5	pEC50	=	8.5	Functional	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	CHEMBL25236	699	30	None	-5	7	Green monkey	8.5	pEC50	=	8.5	Functional	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	3038495	699	30	None	-8	7	Human	8.5	pEC50	=	8.5	Functional	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	7625	699	30	None	-8	7	Human	8.5	pEC50	=	8.5	Functional	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	CHEMBL25236	699	30	None	-8	7	Human	8.5	pEC50	=	8.5	Functional	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	25139479	183725	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	CHEMBL484202	183725	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	2	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	54562	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	CHEMBL240773	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	54580905	61259	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771107	61259	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	25256814	181020	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477250	181020	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	11983282	138401	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	CHEMBL378455	138401	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	2	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3198	19	None	2	7	Human	8.5	pEC50	=	8.5	Functional	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219<

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Ligand source activities (1 row/activity)