Biased Signaling Atlas

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10456166	119697	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL346692	119697	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL4285942	119697	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	52937876	61194	None	0	Human	Functional	pEC50	=	10.3	10.3	489	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL1765633	61194	None	0	Human	Functional	pEC50	=	10.3	10.3	489	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@H]1CCn2nccc2C1	10.1021/jm101639t
	24866114	178793	None	0	Human	Functional	pEC50	=	10.2	10.2	223	2	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	467	7	1	6	4.4	CCCN(CCN1CCN(c2cccc(Cl)c2Cl)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	CHEMBL468017	178793	None	0	Human	Functional	pEC50	=	10.2	10.2	223	2	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	467	7	1	6	4.4	CCCN(CCN1CCN(c2cccc(Cl)c2Cl)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	24754400	154690	None	0	Human	Functional	pEC50	=	10.1	10.1	19	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	423	8	1	5	3.8	CCCN(CCN1CCN(c2ccccc2OC)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	CHEMBL399164	154690	None	0	Human	Functional	pEC50	=	10.1	10.1	19	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	423	8	1	5	3.8	CCCN(CCN1CCN(c2ccccc2OC)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	24936081	178742	None	0	Human	Functional	pEC50	=	10.1	10.1	234	2	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	CHEMBL467540	178742	None	0	Human	Functional	pEC50	=	10.1	10.1	234	2	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2nc(N)sc2C1	10.1021/jm701524h
	24866612	189730	None	0	Human	Functional	pEC50	=	10.1	10.1	72	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL514885	189730	None	0	Human	Functional	pEC50	=	10.1	10.1	72	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	2	3261	None	19	Human	Functional	pEC50	=	10.0	10.0	2	7	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	54562	3261	None	19	Human	Functional	pEC50	=	10.0	10.0	2	7	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	10.0	10.0	2	7	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1039/C8MD00237A
	56941366	105755	None	0	Human	Functional	pEC50	=	10	10.0	158	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	491	8	2	7	4.5	CCCN(CCN1CCN(c2ccc(-c3cccc(O)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	CHEMBL3125990	105755	None	0	Human	Functional	pEC50	=	10	10.0	158	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	491	8	2	7	4.5	CCCN(CCN1CCN(c2ccc(-c3cccc(O)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	681	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	681.0	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	940	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	947	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	DB00988	1465	None	47	Human	Functional	pEC50	=	10.0	10.0	-2	15	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.9b01835
	24742011	94367	None	0	Human	Functional	pEC50	=	9.9	9.9	18	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	CHEMBL250552	94367	None	0	Human	Functional	pEC50	=	9.9	9.9	18	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2c(O)cccc2C1	10.1021/jm070860r
	128	149	None	8	Human	Functional	pEC50	=	9.9	9.9	9	3	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	172267	149	None	8	Human	Functional	pEC50	=	9.9	9.9	9	3	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	CHEMBL273273	149	None	8	Human	Functional	pEC50	=	9.9	9.9	9	3	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1016/j.bmc.2009.04.031
	119570	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	119570.0	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	2233	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	953	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	CHEMBL301265	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	DB00413	3159	None	58	Rat	Functional	pEC50	=	9.7	9.7	2	11	Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assayEffective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/jm000087z
	17449900	139629	None	9	Human	Functional	pEC50	=	9.7	9.7	1	3	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	CHEMBL379602	139629	None	9	Human	Functional	pEC50	=	9.7	9.7	1	3	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
	52941006	17106	None	0	Human	Functional	pEC50	=	9.6	9.6	208	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2c(O)cccc2C1	10.1016/j.bmc.2010.06.025
	CHEMBL1254947	17106	None	0	Human	Functional	pEC50	=	9.6	9.6	208	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2c(O)cccc2C1	10.1016/j.bmc.2010.06.025
	60148494	80891	None	0	Human	Functional	pEC50	=	9.6	9.6	446	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152747	80891	None	0	Human	Functional	pEC50	=	9.6	9.6	446	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	60165801	80890	None	0	Human	Functional	pEC50	=	9.6	9.6	446	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)C1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	CHEMBL2152746	80890	None	0	Human	Functional	pEC50	=	9.6	9.6	446	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2cc3ccccc3[nH]2)CC1)C1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	85470564	156915	None	0	Human	Functional	pEC50	=	9.5	9.5	37	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071240	156915	None	0	Human	Functional	pEC50	=	9.5	9.5	37	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	137633863	156716	None	0	Human	Functional	pEC50	=	9.5	9.5	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069145	156716	None	0	Human	Functional	pEC50	=	9.5	9.5	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	137633863	156716	None	0	Human	Functional	pEC50	=	9.5	9.5	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069145	156716	None	0	Human	Functional	pEC50	=	9.5	9.5	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	132578416	173910	None	0	Human	Functional	pEC50	=	9.5	9.5	-1	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	383	9	3	4	4.8	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4538230	173910	None	0	Human	Functional	pEC50	=	9.5	9.5	-1	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	383	9	3	4	4.8	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2016.08.021
	25256816	181714	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477206	181714	None	0	Human	Functional	pEC50	=	9.5	9.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	5311346	206612	None	20	Rat	Functional	pEC50	=	9.4	9.4	467	5	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	CHEMBL1256778	206612	None	20	Rat	Functional	pEC50	=	9.4	9.4	467	5	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	CHEMBL70565	206612	None	20	Rat	Functional	pEC50	=	9.4	9.4	467	5	Agonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]-thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	249	2	1	4	1.9	CCCN1CCO[C@@H]2c3cc(O)ccc3OC[C@H]21	10.1021/jm0000113
	9888555	165699	None	19	Human	Functional	pEC50	=	9.4	9.4	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	CHEMBL424294	165699	None	19	Human	Functional	pEC50	=	9.4	9.4	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
	2	3261	None	19	Human	Functional	pEC50	=	9.4	9.4	2	7	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	54562	3261	None	19	Human	Functional	pEC50	=	9.4	9.4	2	7	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	9.4	9.4	2	7	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.9b01835
	137651936	157484	None	0	Human	Functional	pEC50	=	9.4	9.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4078348	157484	None	0	Human	Functional	pEC50	=	9.4	9.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137651936	157484	None	0	Human	Functional	pEC50	=	9.4	9.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4078348	157484	None	0	Human	Functional	pEC50	=	9.4	9.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137660837	159173	None	0	Human	Functional	pEC50	=	9.3	9.3	4	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4097330	159173	None	0	Human	Functional	pEC50	=	9.3	9.3	4	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	137660837	159173	None	0	Human	Functional	pEC50	=	9.3	9.3	4	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	CHEMBL4097330	159173	None	0	Human	Functional	pEC50	=	9.3	9.3	4	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
	45486325	200876	None	0	Human	Functional	pEC50	=	9.3	9.3	158	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2ccnc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL577073	200876	None	0	Human	Functional	pEC50	=	9.3	9.3	158	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2ccnc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	45486330	200248	None	0	Human	Functional	pEC50	=	9.3	9.3	173	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL571992	200248	None	0	Human	Functional	pEC50	=	9.3	9.3	173	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	45486328	199818	None	0	Human	Functional	pEC50	=	9.3	9.3	25	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2cccc3ncccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	CHEMBL569107	199818	None	0	Human	Functional	pEC50	=	9.3	9.3	25	2	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2cccc3ncccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm901184n
	71459659	83869	None	0	Human	Functional	pEC50	=	9.3	9.3	3	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	534	16	2	4	7.7	CCCN(CCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL2206264	83869	None	0	Human	Functional	pEC50	=	9.3	9.3	3	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	534	16	2	4	7.7	CCCN(CCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	11957566	184	None	17	Human	Functional	pEC50	=	9.3	9.3	1	4	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	1219	184	None	17	Human	Functional	pEC50	=	9.3	9.3	1	4	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	3296	184	None	17	Human	Functional	pEC50	=	9.3	9.3	1	4	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	950	184	None	17	Human	Functional	pEC50	=	9.3	9.3	1	4	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	CHEMBL285755	184	None	17	Human	Functional	pEC50	=	9.3	9.3	1	4	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1021/jm701524h
	60148495	80899	None	0	Human	Functional	pEC50	=	9.3	9.3	125	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152755	80899	None	0	Human	Functional	pEC50	=	9.3	9.3	125	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	11299620	97337	None	1	Human	Functional	pEC50	=	9.2	9.2	64	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL269004	97337	None	1	Human	Functional	pEC50	=	9.2	9.2	64	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	247	5	1	2	3.4	CCCN(CCC)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	681	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	681.0	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	940	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	947	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	DB00988	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	681	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	681.0	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	940	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	947	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	DB00988	1465	None	47	Human	Functional	pEC50	=	9.2	9.2	-2	15	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00417
	10178704	49673	None	0	Human	Functional	pEC50	=	9.2	9.2	17	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm070860r
	CHEMBL156639	49673	None	0	Human	Functional	pEC50	=	9.2	9.2	17	2	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm070860r
	14465382	157074	None	1	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	386	7	2	3	6.2	CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	CHEMBL4073068	157074	None	1	Human	Functional	pEC50	=	9.1	9.1	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	386	7	2	3	6.2	CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	45140376	203114	None	0	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm901618d
	CHEMBL599635	203114	None	0	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2ccc(O)cc2C1	10.1021/jm901618d
	155522454	170818	None	0	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	403	10	2	6	4.4	CCCN(CCCCCc1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4452046	170818	None	0	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	403	10	2	6	4.4	CCCN(CCCCCc1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	119570	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	119570.0	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	2233	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	953	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	CHEMBL301265	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	DB00413	3159	None	58	Human	Functional	pEC50	=	9.1	9.1	-2	11	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1021/acs.jmedchem.1c00692
	45486330	200248	None	0	Human	Functional	pEC50	=	9.1	9.1	173	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL571992	200248	None	0	Human	Functional	pEC50	=	9.1	9.1	173	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	45486330	200248	None	0	Human	Functional	pEC50	=	9.1	9.1	173	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	CHEMBL571992	200248	None	0	Human	Functional	pEC50	=	9.1	9.1	173	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	450	7	1	7	3.7	CCCN(CCN1CCN(c2nccc3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2013.03.059
	127038171	137010	None	0	Human	Functional	pEC50	=	9.1	9.1	46	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742140	137010	None	0	Human	Functional	pEC50	=	9.1	9.1	46	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742430	137010	None	0	Human	Functional	pEC50	=	9.1	9.1	46	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	137460109	191492	None	0	Human	Functional	pEC50	=	9.1	9.1	-3	2	Agonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS bindingAgonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS binding	ChEMBL	482	7	2	4	5.4	CCCN(CCN1CCN(c2ccc3c(c2)[nH]c2ccccc23)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5192367	191492	None	0	Human	Functional	pEC50	=	9.1	9.1	-3	2	Agonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS bindingAgonist activity at dopamine D3 receptor (unknown origin) assessed as increase in GTPgammaS binding	ChEMBL	482	7	2	4	5.4	CCCN(CCN1CCN(c2ccc3c(c2)[nH]c2ccccc23)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.ejmech.2022.114378
	60148496	80896	None	0	Human	Functional	pEC50	=	9.1	9.1	100	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2c[nH]c3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152752	80896	None	0	Human	Functional	pEC50	=	9.1	9.1	100	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	466	7	2	6	3.2	CCCN(CCN1CCN(C(=O)c2c[nH]c3ccccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	681	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	681.0	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	940	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	947	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	DB00988	1465	None	47	Human	Functional	pEC50	=	9.1	9.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.1c00611
	85470564	156915	None	0	Human	Functional	pEC50	=	9.1	9.1	37	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071240	156915	None	0	Human	Functional	pEC50	=	9.1	9.1	37	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466573	158628	None	0	Human	Functional	pEC50	=	9.1	9.1	16	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4091498	158628	None	0	Human	Functional	pEC50	=	9.1	9.1	16	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466716	161097	None	0	Human	Functional	pEC50	=	9.1	9.1	1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099236	161097	None	0	Human	Functional	pEC50	=	9.1	9.1	1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116199	161097	None	0	Human	Functional	pEC50	=	9.1	9.1	1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	85469680	156807	None	0	Human	Functional	pEC50	=	9.0	9.0	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156807	None	0	Human	Functional	pEC50	=	9.0	9.0	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	71459660	83870	None	0	Human	Functional	pEC50	=	9.0	9.0	-2	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	548	17	2	4	8.1	CCCN(CCCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	CHEMBL2206265	83870	None	0	Human	Functional	pEC50	=	9.0	9.0	-2	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	548	17	2	4	8.1	CCCN(CCCCCCCCCCN(CCC)[C@H]1CCc2c(O)cccc2C1)[C@H]1CCc2c(O)cccc2C1	10.1021/ml3002117
	11957566	184	None	17	Human	Functional	pEC50	=	9.0	9.0	1	4	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	1219	184	None	17	Human	Functional	pEC50	=	9.0	9.0	1	4	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	3296	184	None	17	Human	Functional	pEC50	=	9.0	9.0	1	4	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	950	184	None	17	Human	Functional	pEC50	=	9.0	9.0	1	4	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	CHEMBL285755	184	None	17	Human	Functional	pEC50	=	9.0	9.0	1	4	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cc(cc2)O)CCC	10.1016/j.bmc.2012.08.058
	44427827	93328	None	0	Human	Functional	pEC50	=	9	9.0	15	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL244990	93328	None	0	Human	Functional	pEC50	=	9	9.0	15	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	119570	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	119570.0	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	2233	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	953	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	CHEMBL301265	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	DB00413	3159	None	58	Human	Functional	pEC50	=	9	9.0	-2	11	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/j.bmcl.2007.10.059
	57242	3259	None	18	Human	Functional	pEC50	=	9	9.0	9	4	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	954	3259	None	18	Human	Functional	pEC50	=	9	9.0	9	4	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	CHEMBL155731	3259	None	18	Human	Functional	pEC50	=	9	9.0	9	4	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	246	2	1	4	1.6	CCCN1CCC[C@H]2[C@H]1Cc1cnc(nc1C2)N	10.1016/j.bmcl.2007.10.059
	85469680	156807	None	0	Human	Functional	pEC50	=	9	9.0	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156807	None	0	Human	Functional	pEC50	=	9	9.0	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158686	None	0	Human	Functional	pEC50	=	9	9.0	3	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158686	None	0	Human	Functional	pEC50	=	9	9.0	3	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158686	None	0	Human	Functional	pEC50	=	9	9.0	3	2	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	CHEMBL4092052	158686	None	0	Human	Functional	pEC50	=	9	9.0	3	2	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	16038360	16976	None	0	Human	Functional	pEC50	=	9.0	9.0	104	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2ccc(O)cc2C1	10.1016/j.bmc.2010.06.025
	CHEMBL1253770	16976	None	0	Human	Functional	pEC50	=	9.0	9.0	104	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	469	8	1	4	5.5	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)C1CCc2ccc(O)cc2C1	10.1016/j.bmc.2010.06.025
	10411237	117546	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL339960	117546	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	CHEMBL4287055	117546	None	0	Human	Functional	pEC50	=	9.0	9.0	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assayAgonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay	ChEMBL	444	7	2	3	4.8	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2[nH]1	10.1039/C8MD00237A
	137660062	159480	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	370	7	1	2	6.5	CCCCCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	CHEMBL4100634	159480	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	370	7	1	2	6.5	CCCCCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(CO)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	10368423	97980	None	0	Green monkey	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration for Dopamine receptor D3 was determinedEffective concentration for Dopamine receptor D3 was determined	ChEMBL	493	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)cc2)CC1	10.1021/jm030836n
	CHEMBL27254	97980	None	0	Green monkey	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration for Dopamine receptor D3 was determinedEffective concentration for Dopamine receptor D3 was determined	ChEMBL	493	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)cc2)CC1	10.1021/jm030836n
	155531663	171772	None	0	Human	Functional	pEC50	=	8.9	8.9	7	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1cc(O)ccc1O)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4466245	171772	None	0	Human	Functional	pEC50	=	8.9	8.9	7	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1cc(O)ccc1O)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	45273211	198083	None	0	Human	Functional	pEC50	=	8.9	8.9	33	2	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	7	2	4	3.9	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2009.04.031
	CHEMBL556269	198083	None	0	Human	Functional	pEC50	=	8.9	8.9	33	2	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	460	7	2	4	3.9	CCCN(CCN1CCN(C(=O)c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2c(O)cccc2C1	10.1016/j.bmc.2009.04.031
	128	149	None	8	Human	Functional	pEC50	=	8.9	8.9	9	3	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	172267	149	None	8	Human	Functional	pEC50	=	8.9	8.9	9	3	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	CHEMBL273273	149	None	8	Human	Functional	pEC50	=	8.9	8.9	9	3	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)cccc2O)CCC	10.1021/jm901184n
	60148497	80883	None	0	Human	Functional	pEC50	=	8.9	8.9	2	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	7	2	6	3.6	CCCN(CCN1CCN(c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL2152633	80883	None	0	Human	Functional	pEC50	=	8.9	8.9	2	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	7	2	6	3.6	CCCN(CCN1CCN(c2ccc3[nH]ccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	2	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	54562	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2010.12.083
	90467024	157781	None	0	Human	Functional	pEC50	=	8.9	8.9	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157781	None	0	Human	Functional	pEC50	=	8.9	8.9	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	2	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	54562	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.9	8.9	2	7	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050170s
	10476504	33495	None	1	Human	Functional	pEC50	=	8.9	8.9	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	CHEMBL142020	33495	None	1	Human	Functional	pEC50	=	8.9	8.9	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
	127037825	137006	None	0	Human	Functional	pEC50	=	8.9	8.9	2	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3740041	137006	None	0	Human	Functional	pEC50	=	8.9	8.9	2	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742426	137006	None	0	Human	Functional	pEC50	=	8.9	8.9	2	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2ccc3cc[nH]c3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	24759792	184514	None	0	Human	Functional	pEC50	=	8.9	8.9	190	2	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	286	2	1	3	2.0	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CNC4=O	10.1016/j.bmcl.2009.03.015
	CHEMBL484598	184514	None	0	Human	Functional	pEC50	=	8.9	8.9	190	2	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	286	2	1	3	2.0	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CNC4=O	10.1016/j.bmcl.2009.03.015
	90467024	157781	None	0	Human	Functional	pEC50	=	8.9	8.9	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157781	None	0	Human	Functional	pEC50	=	8.9	8.9	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	60194424	80467	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	511	9	2	7	4.3	CCCN(CC[C@H]1CC[C@H](NS(=O)(=O)c2cccnc2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	CHEMBL2146499	80467	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	511	9	2	7	4.3	CCCN(CC[C@H]1CC[C@H](NS(=O)(=O)c2cccnc2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	119570	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	119570.0	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	2233	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	953	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	CHEMBL301265	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	DB00413	3159	None	58	Human	Functional	pEC50	=	8.8	8.8	-2	11	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1016/s0960-894x(02)00390-6
	10092819	16780	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	CHEMBL124444	16780	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
	24866612	189730	None	0	Human	Functional	pEC50	=	8.8	8.8	72	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	CHEMBL514885	189730	None	0	Human	Functional	pEC50	=	8.8	8.8	72	2	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	475	8	1	6	4.8	CCCN(CCN1CCN(c2ccc(-c3ccccc3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm300268s
	53361666	190730	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	466	7	2	8	3.4	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5181007	190730	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting methodAgonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting method	ChEMBL	466	7	2	8	3.4	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	45140377	203115	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2c(O)cccc2C1	10.1021/jm901618d
	CHEMBL599636	203115	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	460	7	2	6	4.0	CCCN(CCN1CCN(c2ccnc3c(O)cccc23)CC1)C1CCc2c(O)cccc2C1	10.1021/jm901618d
	169410194	196730	None	6	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5431103	196730	None	6	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	169410194	196730	None	6	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5431103	196730	None	6	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	681	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	681.0	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	940	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	947	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.8	8.8	-2	15	Agonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysisAgonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as cAMP production incubated for 30 mins in the presence of NKH-477 by fluorescence based analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	171492446	196607	None	0	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	406	6	1	4	3.2	COc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1F	10.1021/acs.jmedchem.2c01624
	CHEMBL5427695	196607	None	0	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	406	6	1	4	3.2	COc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1F	10.1021/acs.jmedchem.2c01624
	171492446	196607	None	0	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	406	6	1	4	3.2	COc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1F	10.1021/acs.jmedchem.2c01624
	CHEMBL5427695	196607	None	0	Human	Functional	pEC50	=	8.8	8.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	406	6	1	4	3.2	COc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1F	10.1021/acs.jmedchem.2c01624
	137660417	159248	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	159248	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	53475319	83548	None	8	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrsAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs	ChEMBL	478	8	3	6	4.2	CCCN(CC[C@]1(O)C[C@H](NC(=O)c2ccc3ccccc3c2)C1)[C@H]1CCc2nc(N)sc2C1	10.1021/ml200100t
	CHEMBL2203406	83548	None	8	Human	Functional	pEC50	=	8.8	8.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrsAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs	ChEMBL	478	8	3	6	4.2	CCCN(CC[C@]1(O)C[C@H](NC(=O)c2ccc3ccccc3c2)C1)[C@H]1CCc2nc(N)sc2C1	10.1021/ml200100t
	2	3261	None	19	Rat	Functional	pEC50	=	8.8	8.8	-4	7	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	54562	3261	None	19	Rat	Functional	pEC50	=	8.8	8.8	-4	7	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	CHEMBL240773	3261	None	19	Rat	Functional	pEC50	=	8.8	8.8	-4	7	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0000113
	2	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	54562	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00692
	2	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	54562	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.8	8.8	2	7	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2021.113190
	3038495	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	7625	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	CHEMBL25236	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
	3038495	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	7625	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	CHEMBL25236	708	None	33	Human	Functional	pEC50	=	8.7	8.7	-8	8	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
	11154555	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	11154555.0	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	5037	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	7671	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL2028019	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL3085826	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	DB06016	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	25071384	111844	None	0	Human	Functional	pEC50	=	8.7	8.7	251	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287397	111844	None	0	Human	Functional	pEC50	=	8.7	8.7	251	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	11154555	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	11154555.0	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	5037	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	7671	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL2028019	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL3085826	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	DB06016	800	None	50	Human	Functional	pEC50	=	8.7	8.7	-1	10	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	25071384	111844	None	0	Human	Functional	pEC50	=	8.7	8.7	251	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287397	111844	None	0	Human	Functional	pEC50	=	8.7	8.7	251	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	2	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.7	8.7	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3261	None	19	Human	Functional	pEC50	=	8	8.0	2	7	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	54562	3261	None	19	Human	Functional	pEC50	=	8	8.0	2	7	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8	8.0	2	7	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	16078	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	16078.0	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	2424	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	4109	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	CHEMBL465	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	DB00470	1362	None	15	Human	Functional	pEC50	=	8.0	8.0	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1021/acs.jmedchem.6b01578
	2402	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	5095	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	5095.0	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	7295	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	CHEMBL589	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	DB00268	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmc.2010.06.025
	2402	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	5095	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	5095.0	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	7295	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	CHEMBL589	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	DB00268	3370	None	38	Human	Functional	pEC50	=	8.0	8.0	5	17	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901618d
	127047458	139822	None	0	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	419	7	1	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3798334	139822	None	0	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	419	7	1	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	681	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	681.0	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	940	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	947	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401883v
	127037828	137009	None	0	Human	Functional	pEC50	=	8.0	8.0	30	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3740778	137009	None	0	Human	Functional	pEC50	=	8.0	8.0	30	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742429	137009	None	0	Human	Functional	pEC50	=	8.0	8.0	30	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	469	6	2	7	3.4	N#CCN(CCN1CCN(c2ccc3[nH]ccc3c2Cl)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	77461254	191333	None	0	Human	Functional	pEC50	=	7	7.0	-1	2	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	477	8	1	8	3.6	CCCN(CCN1CCN(c2ccc(-c3ccccn3)nc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL5189785	191333	None	0	Human	Functional	pEC50	=	7	7.0	-1	2	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	477	8	1	8	3.6	CCCN(CCN1CCN(c2ccc(-c3ccccn3)nc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.ejmech.2022.114378
	164609493	184542	None	0	Human	Functional	pEC50	=	7.0	7.0	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
	CHEMBL4846380	184542	None	0	Human	Functional	pEC50	=	7.0	7.0	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	350	6	4	5	1.9	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1	10.1016/j.ejmech.2021.113190
	168292954	193106	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5202592	193106	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222660	193106	None	0	Human	Functional	pEC50	=	6.0	6.0	-7	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.5	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2cnc(N)s2)cc1	10.1021/acs.jmedchem.1c00692
	168295541	193149	None	0	Human	Functional	pEC50	=	6.0	6.0	-14	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5208845	193149	None	0	Human	Functional	pEC50	=	6.0	6.0	-14	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222926	193149	None	0	Human	Functional	pEC50	=	6.0	6.0	-14	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	347	6	4	5	1.4	C[C@@H](NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	90467323	159652	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4102620	159652	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	122181332	121939	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590083	121939	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	90467022	156010	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4C(F)(F)F)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4060896	156010	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4C(F)(F)F)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	127045794	140195	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3797771	140195	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800680	140195	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	487	7	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(O)c2ccccc12	10.1039/C5MD00590F
	127046015	140199	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	CHEMBL3799465	140199	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	CHEMBL3800684	140199	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	477	7	1	5	5.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2sccc12	10.1039/C5MD00590F
	25072635	111846	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	CHEMBL3287399	111846	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	90467323	159652	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4102620	159652	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	11706497	78206	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	CHEMBL210461	78206	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
	25072635	111846	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	CHEMBL3287399	111846	None	0	Human	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccc12	10.1021/jm5004039
	122181332	121939	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590083	121939	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	432	9	1	3	5.6	CCCN(CCCCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	164619170	185707	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164619170	185707	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	25071692	111852	None	0	Human	Functional	pEC50	=	7.9	7.9	9	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287405	111852	None	0	Human	Functional	pEC50	=	7.9	7.9	9	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	90467322	156901	None	0	Human	Functional	pEC50	=	7.9	7.9	-6	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156901	None	0	Human	Functional	pEC50	=	7.9	7.9	-6	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	25071692	111852	None	0	Human	Functional	pEC50	=	7.9	7.9	9	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287405	111852	None	0	Human	Functional	pEC50	=	7.9	7.9	9	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	155516042	176398	None	0	Human	Functional	pEC50	=	7.9	7.9	794	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4443039	176398	None	0	Human	Functional	pEC50	=	7.9	7.9	794	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4595150	176398	None	0	Human	Functional	pEC50	=	7.9	7.9	794	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	164628178	186453	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164628178	186453	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	7.9	7.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	90467172	156987	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4072140	156987	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90467317	155881	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.1	O=C(NCCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4059573	155881	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.1	O=C(NCCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	168295528	193140	None	0	Human	Functional	pEC50	=	5.9	5.9	-56	9	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193140	None	0	Human	Functional	pEC50	=	5.9	5.9	-56	9	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193140	None	0	Human	Functional	pEC50	=	5.9	5.9	-56	9	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	172463952	196538	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	172463952	196538	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	6.9	6.9	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	164628178	186453	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164628178	186453	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4875081	186453	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	412	9	2	4	4.4	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	9828632	100124	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	535	6	1	4	5.5	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL287198	100124	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	535	6	1	4	5.5	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	90467173	158290	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	443	8	1	4	5.4	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4087889	158290	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	443	8	1	4	5.4	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	164938010	195433	None	0	Human	Functional	pEC50	=	4.9	4.9	-117	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccc2nc(CCCN3CCN(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5403610	195433	None	0	Human	Functional	pEC50	=	4.9	4.9	-117	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccc2nc(CCCN3CCN(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	44443903	154167	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	219	3	1	3	2.0	C=CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL398480	154167	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	219	3	1	3	2.0	C=CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	168294449	193127	None	0	Human	Functional	pEC50	=	5.9	5.9	-50	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	CHEMBL5204599	193127	None	0	Human	Functional	pEC50	=	5.9	5.9	-50	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222793	193127	None	0	Human	Functional	pEC50	=	5.9	5.9	-50	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	367	7	4	5	1.9	CC(CNC(=O)/N=C(\N)NCCCc1nnc(N)s1)C1CCCCC1	10.1021/acs.jmedchem.1c00692
	85469680	156807	None	0	Human	Functional	pEC50	=	7.9	7.9	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4070196	156807	None	0	Human	Functional	pEC50	=	7.9	7.9	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	90466574	158686	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158686	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466425	159408	None	0	Human	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	159408	None	0	Human	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	90467319	161130	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4095588	161130	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116454	161130	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	445	8	1	5	4.7	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	127045797	140198	None	0	Human	Functional	pEC50	=	7.9	7.9	21	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	CHEMBL3798372	140198	None	0	Human	Functional	pEC50	=	7.9	7.9	21	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	CHEMBL3800683	140198	None	0	Human	Functional	pEC50	=	7.9	7.9	21	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	479	7	1	6	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1OCCO2	10.1039/C5MD00590F
	90466574	158686	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4092052	158686	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	127047310	140162	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	433	8	1	5	4.5	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800489	140162	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	433	8	1	5	4.5	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	145988474	167247	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	379	7	2	5	2.8	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(C#N)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4290759	167247	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	379	7	2	5	2.8	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(C#N)cc1)CC2	10.1021/acsmedchemlett.8b00229
	154703875	176553	None	1	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4586582	176553	None	1	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596341	176553	None	1	Human	Functional	pEC50	=	6.8	6.8	6	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	172463952	196538	None	0	Human	Functional	pEC50	=	5.8	5.8	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	5.8	5.8	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5077114	216970	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.1c00611
	172463952	196538	None	0	Human	Functional	pEC50	=	5.8	5.8	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5426242	196538	None	0	Human	Functional	pEC50	=	5.8	5.8	-20	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	418	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3	10.1021/acs.jmedchem.3c00098
	136056636	111851	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287404	111851	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90467021	156762	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156762	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	136056636	111851	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287404	111851	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90467021	156762	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156762	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	164609729	185204	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4856059	185204	None	0	Human	Functional	pEC50	=	7.8	7.8	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	171492372	197072	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5438081	197072	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	164612037	185483	None	0	Human	Functional	pEC50	=	7.8	7.8	6	11	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	CHEMBL4860528	185483	None	0	Human	Functional	pEC50	=	7.8	7.8	6	11	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	90466864	158762	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4092900	158762	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90467171	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	90467171	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	161242	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	11581443	96454	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	367	8	1	4	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1021/jm050729o
	CHEMBL26188	96454	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	367	8	1	4	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1021/jm050729o
	171492372	197072	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5438081	197072	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5089655	217710	None	0	Human	Functional	pEC50	=	6.8	6.8	63	2	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		N#CC(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.1c00611
	164616851	185056	None	0	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4853772	185056	None	0	Human	Functional	pEC50	=	6.8	6.8	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	376	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	137658100	159710	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4103339	159710	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	164937999	197010	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	6	0	5	3.8	c1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5436702	197010	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	6	0	5	3.8	c1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	44309775	102733	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	CHEMBL304605	102733	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	44309775	102733	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1016/s0960-894x(03)00389-5
	CHEMBL304605	102733	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1016/s0960-894x(03)00389-5
	172444851	195152	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	474	10	0	2	6.4	CCCN(CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1)[C@@H]1C[C@H]1c1ccc(Cl)cc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5397609	195152	None	0	Human	Functional	pEC50	=	5.8	5.8	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	474	10	0	2	6.4	CCCN(CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1)[C@@H]1C[C@H]1c1ccc(Cl)cc1	10.1021/acs.jmedchem.3c00417
	154705015	176619	None	1	Human	Functional	pEC50	=	6.8	6.8	91	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4454380	176619	None	1	Human	Functional	pEC50	=	6.8	6.8	91	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596929	176619	None	1	Human	Functional	pEC50	=	6.8	6.8	91	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	25093832	155970	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155970	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467171	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4079093	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117318	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	11678172	78061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	CHEMBL209876	78061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
	90467171	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4079093	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4117318	161242	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	25093832	155970	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155970	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467021	156762	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4069565	156762	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	558	9	2	5	5.6	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	25072941	156565	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4067439	156565	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	11510684	98707	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	CHEMBL277301	98707	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	2	3261	None	19	Human	Functional	pEC50	=	6.7	6.7	2	7	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	54562	3261	None	19	Human	Functional	pEC50	=	6.7	6.7	2	7	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	6.7	6.7	2	7	Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayAgonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.ejmech.2016.07.038
	25072002	156205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063235	156205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	25072941	156565	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4067439	156565	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	90467024	157781	None	0	Human	Functional	pEC50	=	7.7	7.7	10	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4081780	157781	None	0	Human	Functional	pEC50	=	7.7	7.7	10	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	25072002	156205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063235	156205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	127046755	140192	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3798943	140192	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800677	140192	None	0	Human	Functional	pEC50	=	7.7	7.7	-2	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	403	6	1	4	4.4	Cc1ccccc1N1CCN(CCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	2402	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	5095	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	5095.0	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	7295	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	CHEMBL589	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	DB00268	3370	None	38	Human	Functional	pEC50	=	7.7	7.7	5	17	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1021/jm901184n
	242	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	34	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795.0	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	DB01238	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	242	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	34	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795.0	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB01238	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	172464337	196969	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5435745	196969	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	172464337	196969	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5435745	196969	None	0	Human	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	90466867	156402	None	0	Human	Functional	pEC50	=	7.7	7.7	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4065510	156402	None	0	Human	Functional	pEC50	=	7.7	7.7	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	168281746	192991	None	0	Human	Functional	pEC50	=	5.7	5.7	-77	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	CHEMBL5184911	192991	None	0	Human	Functional	pEC50	=	5.7	5.7	-77	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221974	192991	None	0	Human	Functional	pEC50	=	5.7	5.7	-77	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	365	6	4	5	1.6	CC(NC(=O)/N=C(\N)NCCCc1nnc(N)s1)c1cccc(F)c1	10.1021/acs.jmedchem.1c00692
	44436605	149151	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL394292	149151	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
	44400674	125256	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL364516	125256	None	0	Human	Functional	pEC50	=	8.7	8.7	-1	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	681	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	681.0	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	940	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	947	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.7	8.7	-2	15	Agonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assayAgonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 mins by calcium 4-dye based FLIPR assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01096
	44436600	91836	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	CHEMBL241212	91836	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
	90466571	159491	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	458	8	2	5	3.8	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4100735	159491	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	458	8	2	5	3.8	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	25139181	184448	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	CHEMBL484358	184448	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
	11316847	70371	None	0	Human	Functional	pEC50	=	8.7	8.7	6	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm049465g
	CHEMBL194493	70371	None	0	Human	Functional	pEC50	=	8.7	8.7	6	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm049465g
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	15389743	184515	None	0	Human	Functional	pEC50	=	8.6	8.6	1	3	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	274	3	1	3	1.9	CCCN1CCO[C@@H]2c3cc(C(N)=O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.03.015
	CHEMBL484599	184515	None	0	Human	Functional	pEC50	=	8.6	8.6	1	3	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	274	3	1	3	1.9	CCCN1CCO[C@@H]2c3cc(C(N)=O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.03.015
	24805287	184880	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	2	0	4	2.5	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)COC4=O	10.1016/j.bmcl.2009.03.015
	CHEMBL485128	184880	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	2	0	4	2.5	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)COC4=O	10.1016/j.bmcl.2009.03.015
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayAgonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.3c00417
	90466425	159408	None	0	Human	Functional	pEC50	=	8.6	8.6	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	159408	None	0	Human	Functional	pEC50	=	8.6	8.6	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	54580906	61625	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771109	61625	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	90466425	159408	None	0	Human	Functional	pEC50	=	8.6	8.6	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099798	159408	None	0	Human	Functional	pEC50	=	8.6	8.6	10	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)CC1	10.1021/acs.jmedchem.6b01578
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c00611
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2014.12.012
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.2c01624
	122181330	121937	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590081	121937	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	90466717	157002	None	0	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4072282	157002	None	0	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	2	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	54562	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.6	8.6	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm060138d
	155525527	171171	None	0	Human	Functional	pEC50	=	8.6	8.6	8	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4457171	171171	None	0	Human	Functional	pEC50	=	8.6	8.6	8	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	9	3	6	4.1	CCCN(CCCCCc1ccc(O)c(O)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	90466717	157002	None	0	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4072282	157002	None	0	Human	Functional	pEC50	=	8.6	8.6	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	3038495	708	None	33	Human	Functional	pEC50	=	8.6	8.6	-8	8	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	7625	708	None	33	Human	Functional	pEC50	=	8.6	8.6	-8	8	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	CHEMBL25236	708	None	33	Human	Functional	pEC50	=	8.6	8.6	-8	8	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
	1353	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	3559	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	3559.0	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	86	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL54	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	DB00502	1911	None	63	Human	Functional	pEC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	46893146	61627	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771110	61627	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	10084583	104834	None	3	Human	Functional	pEC50	=	8.6	8.6	9	3	Effective concentration required for agonistic activity against human Dopamine receptor D3Effective concentration required for agonistic activity against human Dopamine receptor D3	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	CHEMBL310867	104834	None	3	Human	Functional	pEC50	=	8.6	8.6	9	3	Effective concentration required for agonistic activity against human Dopamine receptor D3Effective concentration required for agonistic activity against human Dopamine receptor D3	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
	172444647	195417	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	421	9	1	5	3.1	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(OC)c3F)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5403268	195417	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	421	9	1	5	3.1	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(OC)c3F)CC2)CC1	10.1021/acs.jmedchem.2c01624
	172444647	195417	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	421	9	1	5	3.1	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(OC)c3F)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5403268	195417	None	0	Human	Functional	pEC50	=	8.5	8.5	-1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	421	9	1	5	3.1	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(OC)c3F)CC2)CC1	10.1021/acs.jmedchem.2c01624
	2	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	54562	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm800895v
	44588497	175739	None	0	Human	Functional	pEC50	=	8.5	8.5	3	2	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)[C@H]1CCc2ccc(O)cc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL458088	175739	None	0	Human	Functional	pEC50	=	8.5	8.5	3	2	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	393	7	1	4	3.8	CCCN(CCN1CCN(c2ccccc2)CC1)[C@H]1CCc2ccc(O)cc2C1	10.1016/j.ejmech.2022.114378
	242	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	34	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	60795.0	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	DB01238	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
	242	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	34	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	60795.0	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL1112	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB01238	470	None	70	Human	Functional	pEC50	=	7.7	7.7	-6	33	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	90466867	156402	None	0	Human	Functional	pEC50	=	7.7	7.7	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4065510	156402	None	0	Human	Functional	pEC50	=	7.7	7.7	5	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	44438230	93610	None	2	Human	Functional	pEC50	=	7.7	7.7	-9	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	2	2	4.6	Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246439	93610	None	2	Human	Functional	pEC50	=	7.7	7.7	-9	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	2	2	4.6	Cc1[nH]c2ccccc2c1CN1CCC(O)(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2006.10.076
	155563589	175422	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	401	9	2	6	4.5	CCCN(CCC/C=C/c1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	CHEMBL4573578	175422	None	0	Human	Functional	pEC50	=	7.7	7.7	1	2	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	401	9	2	6	4.5	CCCN(CCC/C=C/c1ccc(O)c(OC)c1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmc.2016.08.021
	127046238	139774	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)OC1CCCc2ccccc21	10.1039/C5MD00590F
	CHEMBL3798010	139774	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)OC1CCCc2ccccc21	10.1039/C5MD00590F
	172450959	195711	None	0	Human	Functional	pEC50	=	6.7	6.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	6.7	6.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	172450959	195711	None	0	Human	Functional	pEC50	=	5.7	5.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	5.7	5.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	11596603	9936	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	405	7	1	3	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm050729o
	CHEMBL114541	9936	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	405	7	1	3	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm050729o
	172450959	195711	None	0	Human	Functional	pEC50	=	6.7	6.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	6.7	6.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	172450959	195711	None	0	Human	Functional	pEC50	=	5.7	5.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	CHEMBL5409419	195711	None	0	Human	Functional	pEC50	=	5.7	5.7	-162	4	Partial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assayPartial agonist activity at Dopamine D3 receptor (unknown origin) expressed in HEK293T co-expressing G-alpha oA assessed as increase in cAMP accumulation incubated for 5 mins by BRET assay	ChEMBL	420	7	1	5	4.5	COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3	10.1021/acs.jmedchem.3c00098
	127046753	140191	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3799147	140191	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	CHEMBL3800675	140191	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	417	7	1	4	4.8	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2cccc3ccccc23)CC1	10.1039/C5MD00590F
	137660417	159248	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	159248	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	42625290	56262	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL1627316	56262	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	137660417	159248	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4098174	159248	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	527	9	1	5	6.4	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	164622330	185968	None	0	Human	Functional	pEC50	=	6.6	6.6	11	2	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4867962	185968	None	0	Human	Functional	pEC50	=	6.6	6.6	11	2	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	360	6	4	4	2.3	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1	10.1016/j.ejmech.2021.113190
	162665657	182482	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	427	7	1	4	4.8	O=C(NC/C=C/CN1CCN(c2ccccc2)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	CHEMBL4785109	182482	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	427	7	1	4	4.8	O=C(NC/C=C/CN1CCN(c2ccccc2)CC1)Oc1ccc(-c2ccccc2)cc1	10.1016/j.ejmech.2019.111975
	164614549	185049	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	CHEMBL4853668	185049	None	0	Human	Functional	pEC50	=	7.6	7.6	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	340	9	4	4	2.2	CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1016/j.ejmech.2021.113190
	90467322	156901	None	0	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156901	None	0	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	44438197	153361	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL397770	153361	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2cccc(Cl)c2Cl)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	56852956	112106	None	1	Human	Functional	pEC50	=	5.6	5.6	-281	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL3289656	112106	None	1	Human	Functional	pEC50	=	5.6	5.6	-281	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	90467322	156901	None	0	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071121	156901	None	0	Human	Functional	pEC50	=	5.6	5.6	-6	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	472	8	2	5	5.0	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc3c(c2)[nH]c2ccccc23)CC1	10.1021/acs.jmedchem.6b01578
	11307083	63576	None	0	Human	Functional	pEC50	=	7.6	7.6	6	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm049465g
	CHEMBL180060	63576	None	0	Human	Functional	pEC50	=	7.6	7.6	6	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm049465g
	90467170	161248	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4063681	161248	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117347	161248	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	497	8	1	4	6.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.6b01578
	44438228	93609	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	4	1	2	5.0	COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246438	93609	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	4	1	2	5.0	COC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	2	3261	None	19	Human	Functional	pEC50	=	7.6	7.6	2	7	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	54562	3261	None	19	Human	Functional	pEC50	=	7.6	7.6	2	7	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	7.6	7.6	2	7	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm050729o
	164916968	196909	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	CHEMBL5434650	196909	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	127045793	140194	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3798841	140194	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800679	140194	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	501	8	1	5	5.8	COc1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	164916968	196909	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	CHEMBL5434650	196909	None	0	Human	Functional	pEC50	=	7.6	7.6	12	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	CHEMBL5073754	216793	None	0	Human	Functional	pEC50	=	7.6	7.6	41	2	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		CN(C)C(=O)C(CCNCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.1c00611
	137659303	159398	None	0	Human	Functional	pEC50	=	7.6	7.6	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4099711	159398	None	0	Human	Functional	pEC50	=	7.6	7.6	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	164608815	184560	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
	CHEMBL4846638	184560	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	380	7	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1	10.1016/j.ejmech.2021.113190
	168475887	195235	None	2	Human	Functional	pEC50	=	6.6	6.6	10	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL5399270	195235	None	2	Human	Functional	pEC50	=	6.6	6.6	10	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	137659303	159398	None	0	Human	Functional	pEC50	=	7.6	7.6	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4099711	159398	None	0	Human	Functional	pEC50	=	7.6	7.6	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	15006491	4562	None	3	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL102463	4562	None	3	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	168475888	196855	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	410	6	1	3	5.6	Clc1ccc([C@@H]2C[C@H]2NCCC2(c3ccccn3)CCOC3(CCCC3)C2)cc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5433458	196855	None	2	Human	Functional	pEC50	=	6.6	6.6	-1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	410	6	1	3	5.6	Clc1ccc([C@@H]2C[C@H]2NCCC2(c3ccccn3)CCOC3(CCCC3)C2)cc1	10.1021/acs.jmedchem.3c00417
	15232477	169534	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL442535	169534	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(Cl)c3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	25072633	159314	None	0	Human	Functional	pEC50	=	7.5	7.5	-7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098803	159314	None	0	Human	Functional	pEC50	=	7.5	7.5	-7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	164611757	185009	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
	CHEMBL4853107	185009	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	8	4	4	2.8	Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1	10.1016/j.ejmech.2021.113190
	168294767	193128	None	0	Human	Functional	pEC50	=	5.6	5.6	-87	10	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	193128	None	0	Human	Functional	pEC50	=	5.6	5.6	-87	10	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	193128	None	0	Human	Functional	pEC50	=	5.6	5.6	-87	10	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	25072633	159314	None	0	Human	Functional	pEC50	=	7.5	7.5	-7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098803	159314	None	0	Human	Functional	pEC50	=	7.5	7.5	-7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
	154726381	176632	None	1	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4522558	176632	None	1	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597048	176632	None	1	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	168273640	192914	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5176229	192914	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221444	192914	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	568	15	8	10	-0.1	N/C(=N\C(=O)NCCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	164916968	196909	None	0	Human	Functional	pEC50	=	5.5	5.5	12	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	CHEMBL5434650	196909	None	0	Human	Functional	pEC50	=	5.5	5.5	12	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	3038495	708	None	33	Green monkey	Functional	pEC50	=	8.5	8.5	-5	8	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	7625	708	None	33	Green monkey	Functional	pEC50	=	8.5	8.5	-5	8	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	CHEMBL25236	708	None	33	Green monkey	Functional	pEC50	=	8.5	8.5	-5	8	Effective concentration for Dopamine receptor D3 was determined in monkeysEffective concentration for Dopamine receptor D3 was determined in monkeys	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm030836n
	3038495	708	None	33	Human	Functional	pEC50	=	8.5	8.5	-8	8	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	7625	708	None	33	Human	Functional	pEC50	=	8.5	8.5	-8	8	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	CHEMBL25236	708	None	33	Human	Functional	pEC50	=	8.5	8.5	-8	8	Mitogenic stimulation in NG 108-15 cells expressing human D3 receptorMitogenic stimulation in NG 108-15 cells expressing human D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	25139479	184423	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	CHEMBL484202	184423	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
	2	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	54562	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsIntrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm025558r
	54580905	61623	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL1771107	61623	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	25256814	181718	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	CHEMBL477250	181718	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporation	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
	11983282	139030	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	CHEMBL378455	139030	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
	2	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	2	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	54562	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/acs.jmedchem.1c01327
	44427836	144048	None	0	Human	Functional	pEC50	=	8.5	8.5	20	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL390253	144048	None	0	Human	Functional	pEC50	=	8.5	8.5	20	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	2	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2006.02.075
	54562	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2006.02.075
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.5	8.5	2	7	Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayIntrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmcl.2006.02.075
	76329028	105752	None	0	Human	Functional	pEC50	=	8.5	8.5	10	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	505	9	1	7	4.8	CCCN(CCN1CCN(c2ccc(-c3cccc(OC)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	CHEMBL3125987	105752	None	0	Human	Functional	pEC50	=	8.5	8.5	10	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	505	9	1	7	4.8	CCCN(CCN1CCN(c2ccc(-c3cccc(OC)c3)cc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm401883v
	681	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	681.0	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	940	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	947	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.5	8.5	-2	15	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.0c00424
	44436608	146844	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	CHEMBL392437	146844	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
	44400626	70426	None	0	Human	Functional	pEC50	=	8.5	8.5	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL194555	70426	None	0	Human	Functional	pEC50	=	8.5	8.5	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	154726792	176689	None	1	Human	Functional	pEC50	=	8.5	8.5	676	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4475406	176689	None	1	Human	Functional	pEC50	=	8.5	8.5	676	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4597530	176689	None	1	Human	Functional	pEC50	=	8.5	8.5	676	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	90467168	158544	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4090581	158544	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90467168	158544	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	CHEMBL4090581	158544	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Partial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayPartial agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	137634366	156135	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4062484	156135	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	137640863	157146	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4073966	157146	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	472	9	2	5	4.1	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4ccccc4)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	137633705	156709	None	0	Human	Functional	pEC50	=	8.4	8.4	158	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
	CHEMBL4069091	156709	None	0	Human	Functional	pEC50	=	8.4	8.4	158	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
	11761412	117015	None	0	Human	Functional	pEC50	=	8.4	8.4	-2	2	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr-negative cells assessed as stimulation of [3H]-thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in CHO dhfr-negative cells assessed as stimulation of [3H]-thymidine incorporation	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
	CHEMBL338606	117015	None	0	Human	Functional	pEC50	=	8.4	8.4	-2	2	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr-negative cells assessed as stimulation of [3H]-thymidine incorporationAgonist activity at human dopamine D3 receptor expressed in CHO dhfr-negative cells assessed as stimulation of [3H]-thymidine incorporation	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
	44427835	92218	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	540	9	1	6	4.9	CC(=O)OC(CCNC(=O)c1ccc(-c2ccccn2)cc1)CN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm0704200
	CHEMBL242434	92218	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	540	9	1	6	4.9	CC(=O)OC(CCNC(=O)c1ccc(-c2ccccn2)cc1)CN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm0704200
	90467323	159652	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4102620	159652	None	0	Human	Functional	pEC50	=	8.4	8.4	-1	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	532	11	2	7	4.2	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	44400585	68677	None	0	Human	Functional	pEC50	=	8.4	8.4	-2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL191962	68677	None	0	Human	Functional	pEC50	=	8.4	8.4	-2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	127037826	137007	None	0	Human	Functional	pEC50	=	8.4	8.4	8	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2c(Cl)ccc3[nH]ccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3740286	137007	None	0	Human	Functional	pEC50	=	8.4	8.4	8	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2c(Cl)ccc3[nH]ccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	CHEMBL3742427	137007	None	0	Human	Functional	pEC50	=	8.4	8.4	8	2	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	472	7	2	6	4.3	CCCN(CCN1CCN(c2c(Cl)ccc3[nH]ccc23)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/acs.jmedchem.5b01031
	71660285	90650	None	0	Human	Functional	pEC50	=	7.5	7.5	5	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	392	7	1	4	3.7	CCCN(CCN1CCN(c2ccccc2)CC1)[C@@H]1CCc2ccc(N)cc2C1	10.1016/j.bmc.2013.03.059
	CHEMBL2387709	90650	None	0	Human	Functional	pEC50	=	7.5	7.5	5	2	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	392	7	1	4	3.7	CCCN(CCN1CCN(c2ccccc2)CC1)[C@@H]1CCc2ccc(N)cc2C1	10.1016/j.bmc.2013.03.059
	137651073	157560	None	0	Human	Functional	pEC50	=	7.5	7.5	36	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4079301	157560	None	0	Human	Functional	pEC50	=	7.5	7.5	36	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	164610892	185304	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
	CHEMBL4857560	185304	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	394	8	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1	10.1016/j.ejmech.2021.113190
	137651073	157560	None	0	Human	Functional	pEC50	=	7.5	7.5	36	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4079301	157560	None	0	Human	Functional	pEC50	=	7.5	7.5	36	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	44309510	102177	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	531	7	1	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1016/s0960-894x(03)00389-5
	CHEMBL302374	102177	None	0	Human	Functional	pEC50	=	7.5	7.5	1	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	531	7	1	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1016/s0960-894x(03)00389-5
	172449716	195885	None	0	Human	Functional	pEC50	=	6.5	6.5	8	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	682	13	1	6	5.0	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5412606	195885	None	0	Human	Functional	pEC50	=	6.5	6.5	8	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	682	13	1	6	5.0	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	10466682	94289	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	237	3	2	4	1.9	CCCN1CCO[C@H](c2cc(O)cc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL250003	94289	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	237	3	2	4	1.9	CCCN1CCO[C@H](c2cc(O)cc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	71452040	1091	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	295	8	1	2	3.9	Oc1cccc(c1)CCN(CC1CC1)CCc1ccccc1	10.1021/jm301258w
	9190	1091	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	295	8	1	2	3.9	Oc1cccc(c1)CCN(CC1CC1)CCc1ccccc1	10.1021/jm301258w
	CHEMBL2180638	1091	None	1	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	295	8	1	2	3.9	Oc1cccc(c1)CCN(CC1CC1)CCc1ccccc1	10.1021/jm301258w
	90466716	161097	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099236	161097	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116199	161097	None	0	Human	Functional	pEC50	=	6.5	6.5	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	164611342	185194	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4856005	185194	None	0	Human	Functional	pEC50	=	7.5	7.5	1	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	346	6	4	4	1.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1	10.1016/j.ejmech.2021.113190
	90467321	161209	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	459	9	1	5	5.1	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4068218	161209	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	459	9	1	5	5.1	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4117124	161209	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	459	9	1	5	5.1	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3ccccc3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	137634366	156135	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4062484	156135	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	137634366	156135	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4062484	156135	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	515	8	1	4	6.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)c(F)c1	10.1021/acs.jmedchem.6b01578
	44438218	93502	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	338	3	1	1	5.4	CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246020	93502	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	338	3	1	1	5.4	CC1(c2ccc(Cl)cc2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	44443923	155051	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	239	3	1	3	2.3	CCCN1CCOC(c2ccc(F)c(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL401157	155051	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	239	3	1	3	2.3	CCCN1CCOC(c2ccc(F)c(O)c2)C1	10.1016/j.bmcl.2007.10.059
	10014484	94288	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	239	3	1	3	2.3	CCCN1CCO[C@H](c2ccc(F)c(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL250002	94288	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	239	3	1	3	2.3	CCCN1CCO[C@H](c2ccc(F)c(O)c2)C1	10.1016/j.bmcl.2007.10.059
	10515841	210724	None	0	Rat	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	265	2	1	4	2.7	CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@@H]21	10.1021/jm0000113
	CHEMBL98836	210724	None	0	Rat	Functional	pEC50	=	7.4	7.4	3	2	Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratAgonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat	ChEMBL	265	2	1	4	2.7	CCCN1CCO[C@@H]2c3cc(O)ccc3SC[C@@H]21	10.1021/jm0000113
	145989012	167402	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	384	8	2	5	3.0	COc1ccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)cc1	10.1021/acsmedchemlett.8b00229
	CHEMBL4293886	167402	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	384	8	2	5	3.0	COc1ccc(C(=O)NCCCCN2CCc3cc(OC)c(O)cc3C2)cc1	10.1021/acsmedchemlett.8b00229
	137636351	155963	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	CHEMBL4060403	155963	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	44443930	154820	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	237	3	2	4	1.9	CCCN1CCOC(c2cc(O)cc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL399892	154820	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	237	3	2	4	1.9	CCCN1CCOC(c2cc(O)cc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	90467452	158532	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4090459	158532	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	164619127	185631	None	0	Human	Functional	pEC50	=	7.4	7.4	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.4	7.4	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	164619127	185631	None	0	Human	Functional	pEC50	=	7.4	7.4	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.4	7.4	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	127045792	140193	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	489	7	1	4	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(F)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3799311	140193	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	489	7	1	4	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(F)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800678	140193	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	489	7	1	4	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(F)c2ccccc12	10.1039/C5MD00590F
	90466867	156402	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4065510	156402	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466867	156402	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	CHEMBL4065510	156402	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation by flourescence assay	ChEMBL	538	8	2	5	5.2	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1016/j.ejmech.2019.111975
	90467172	156987	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4072140	156987	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90467172	156987	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4072140	156987	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	510	7	2	4	6.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	172439985	195264	None	0	Human	Functional	pEC50	=	5.4	5.4	-35	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5399720	195264	None	0	Human	Functional	pEC50	=	5.4	5.4	-35	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	137655735	159084	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4096353	159084	None	0	Human	Functional	pEC50	=	7.4	7.4	12	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	25071691	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	90466864	158762	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4092900	158762	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	90466864	158762	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	CHEMBL4092900	158762	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	496	6	2	4	5.9	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc2c(c1)[nH]c1ccccc12	10.1021/acs.jmedchem.6b01578
	164916930	195492	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	680	13	2	7	4.0	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5404724	195492	None	0	Human	Functional	pEC50	=	6.4	6.4	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	680	13	2	7	4.0	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	25071691	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	60165418	75375	None	0	Human	Functional	pEC50	=	7.4	7.4	-9	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL2037521	75375	None	0	Human	Functional	pEC50	=	7.4	7.4	-9	3	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	168278471	192957	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5183205	192957	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221757	192957	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	312	8	4	4	1.5	CCCCCNC(=O)/N=C(\N)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	681	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	681.0	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	940	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	947	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assayAgonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as beta-arrestin translocation activity incubated for 90 to 180 mins by pathHunter microplate based TANGO assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00976
	2402	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	5095	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	5095.0	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	7295	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	CHEMBL589	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	DB00268	3370	None	38	Human	Functional	pEC50	=	8.4	8.4	5	17	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1016/j.bmcl.2007.10.059
	90467453	158935	None	0	Human	Functional	pEC50	=	8.4	8.4	3	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4094794	158935	None	0	Human	Functional	pEC50	=	8.4	8.4	3	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	681	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	681.0	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	940	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	947	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.4	8.4	-2	15	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.3c00734
	71449211	80472	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	522	9	2	8	5.0	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cccc(-c3noc(C)n3)c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	CHEMBL2146503	80472	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by mitogenesis assay	ChEMBL	522	9	2	8	5.0	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cccc(-c3noc(C)n3)c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1016/j.bmcl.2012.07.003
	90467587	157485	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	570	10	2	6	5.5	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4078351	157485	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	570	10	2	6	5.5	COc1cc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)ccc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b01578
	24805285	184601	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	300	2	1	3	2.1	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CCNC4=O	10.1016/j.bmcl.2009.03.015
	CHEMBL484732	184601	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Activation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assayActivation of human dopamine D3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	300	2	1	3	2.1	CCCN1CCO[C@@H]2c3cc4c(cc3CC[C@H]21)CCNC4=O	10.1016/j.bmcl.2009.03.015
	681	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	681.0	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	940	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	947	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.06.025
	681	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	681.0	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	940	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	947	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901618d
	11224283	133573	None	0	Human	Functional	pEC50	=	8.3	8.3	12	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	433	7	1	4	4.1	COc1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm049465g
	CHEMBL370713	133573	None	0	Human	Functional	pEC50	=	8.3	8.3	12	2	Inhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cellsInhibition of quinpirole stimulation of mitogenesis at human dopamine D3 receptors expressed in Chinese hamster ovary cells	ChEMBL	433	7	1	4	4.1	COc1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm049465g
	44443948	94260	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	236	3	2	4	1.8	CCCN1CCOC(c2ccc(O)c(N)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL249793	94260	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	236	3	2	4	1.8	CCCN1CCOC(c2ccc(O)c(N)c2)C1	10.1016/j.bmcl.2007.10.059
	25093832	155970	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155970	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	90644230	111853	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287406	111853	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	164617783	184696	None	0	Human	Functional	pEC50	=	7.4	7.4	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4848815	184696	None	0	Human	Functional	pEC50	=	7.4	7.4	2	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	388	8	4	4	2.8	CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1	10.1016/j.ejmech.2021.113190
	25093832	155970	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4060461	155970	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	25072632	111839	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl	10.1021/jm5004039
	CHEMBL3287392	111839	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl	10.1021/jm5004039
	90644230	111853	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287406	111853	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	44438201	93660	None	1	Human	Functional	pEC50	=	7.4	7.4	-2	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	CHEMBL246637	93660	None	1	Human	Functional	pEC50	=	7.4	7.4	-2	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	374	3	2	2	5.0	OC1(c2ccc(Cl)c(Cl)c2)CCN(Cc2c[nH]c3ccccc23)CC1	10.1016/j.bmcl.2006.10.076
	25072632	111839	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl	10.1021/jm5004039
	CHEMBL3287392	111839	None	0	Human	Functional	pEC50	=	7.4	7.4	30	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccc4ccnn4c3)CC2)c1Cl	10.1021/jm5004039
	164916997	196206	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	592	10	0	4	6.3	CN(C)C(=O)C(CCN1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)C1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5418819	196206	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	592	10	0	4	6.3	CN(C)C(=O)C(CCN1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)C1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	164916997	196206	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	592	10	0	4	6.3	CN(C)C(=O)C(CCN1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)C1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5418819	196206	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	592	10	0	4	6.3	CN(C)C(=O)C(CCN1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)C1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	164609017	184531	None	0	Human	Functional	pEC50	=	6.4	6.4	6	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4846201	184531	None	0	Human	Functional	pEC50	=	6.4	6.4	6	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	416	10	4	4	3.2	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1	10.1016/j.ejmech.2021.113190
	137640391	156797	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4070091	156797	None	0	Human	Functional	pEC50	=	7.4	7.4	1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	44427829	151342	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	509	7	2	4	4.9	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	CHEMBL396024	151342	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	509	7	2	4	4.9	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm0704200
	25071691	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	25071691	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	CHEMBL3287403	111850	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
	145993700	167426	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	370	7	3	5	2.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(O)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4294279	167426	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	370	7	3	5	2.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(O)cc1)CC2	10.1021/acsmedchemlett.8b00229
	44443944	94194	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	264	4	2	4	1.3	CCCN1CCOC(c2ccc(O)c(C(N)=O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL249357	94194	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	264	4	2	4	1.3	CCCN1CCOC(c2ccc(O)c(C(N)=O)c2)C1	10.1016/j.bmcl.2007.10.059
	137642380	158599	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
	CHEMBL4091155	158599	None	0	Human	Functional	pEC50	=	7.4	7.4	5	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
	71462090	84627	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	CHEMBL2158640	84627	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	CHEMBL2221044	84627	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assayAgonist activity at dopamine D3 receptor in human U2OS-D3 cells assessed as EA-tagged beta-arrestin translocation after 1.5 hrs by luminescence based beta-galactosidase assay	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
	168286426	193035	None	0	Human	Functional	pEC50	=	6.3	6.3	-5	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5198795	193035	None	0	Human	Functional	pEC50	=	6.3	6.3	-5	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222241	193035	None	0	Human	Functional	pEC50	=	6.3	6.3	-5	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	403	10	4	5	2.3	CC(CCCc1ccccc1)CNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	11676873	9197	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	8	1	4	4.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm050729o
	CHEMBL110365	9197	None	0	Human	Functional	pEC50	=	7.3	7.3	21	2	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	8	1	4	4.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm050729o
	145993990	167450	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	372	7	2	4	3.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(F)cc1)CC2	10.1021/acsmedchemlett.8b00229
	CHEMBL4294577	167450	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Antagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assayAntagonist activity at human dopamine D3 receptor assessed as inhibition of beta-arrestin recruitment by Tango assay	ChEMBL	372	7	2	4	3.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(F)cc1)CC2	10.1021/acsmedchemlett.8b00229
	90644228	111849	None	0	Human	Functional	pEC50	=	8.3	8.3	5	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287402	111849	None	0	Human	Functional	pEC50	=	8.3	8.3	5	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90644228	111849	None	0	Human	Functional	pEC50	=	8.3	8.3	5	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287402	111849	None	0	Human	Functional	pEC50	=	8.3	8.3	5	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	164623991	185643	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164623991	185643	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	2	3261	None	19	Human	Functional	pEC50	=	8.3	8.3	2	7	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2007.08.038
	54562	3261	None	19	Human	Functional	pEC50	=	8.3	8.3	2	7	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2007.08.038
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.3	8.3	2	7	Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsAgonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrs	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2007.08.038
	114876	12797	None	1	Human	Functional	pEC50	=	8.3	8.3	7	6	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm301258w
	CHEMBL1188090	12797	None	1	Human	Functional	pEC50	=	8.3	8.3	7	6	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm301258w
	CHEMBL545783	12797	None	1	Human	Functional	pEC50	=	8.3	8.3	7	6	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm301258w
	681	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	681.0	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	940	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	947	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.3	8.3	-2	15	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.5b01031
	11154555	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	11154555.0	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	5037	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	7671	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL2028019	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL3085826	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB06016	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	681	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	681.0	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	940	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	947	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/ml3002117
	11154555	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	11154555.0	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	5037	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	7671	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL2028019	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	CHEMBL3085826	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	DB06016	800	None	50	Human	Functional	pEC50	=	8.2	8.2	-1	10	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
	90644227	111843	None	0	Human	Functional	pEC50	=	8.2	8.2	91	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287396	111843	None	0	Human	Functional	pEC50	=	8.2	8.2	91	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	90644227	111843	None	0	Human	Functional	pEC50	=	8.2	8.2	91	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287396	111843	None	0	Human	Functional	pEC50	=	8.2	8.2	91	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	137640203	157054	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	CHEMBL4072821	157054	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	137640203	157054	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	CHEMBL4072821	157054	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
	52937875	61195	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
	CHEMBL1765634	61195	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation countingAgonist activity at human dopamine D3 receptor expressed in HEK293 cells co-expressing Galphao1 assessed as incorporation of [35S]GTPgammaS into Galphao1 after 30 mins by scintillation counting	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
	5311189	207299	None	9	Human	Functional	pEC50	=	7.3	7.3	2	4	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	10.1021/acs.jmedchem.5b01031
	CHEMBL7549	207299	None	9	Human	Functional	pEC50	=	7.3	7.3	2	4	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	10.1021/acs.jmedchem.5b01031
	90467453	158935	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4094794	158935	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	90467453	158935	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4094794	158935	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	486	9	2	5	4.5	Cc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	164623991	185643	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164623991	185643	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4862890	185643	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	410	10	2	4	4.2	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	172442773	195208	None	0	Human	Functional	pEC50	=	5.3	5.3	-6	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	432	8	1	2	5.3	CN(C)C(=O)C(CCN[C@@H]1C[C@H]1c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5398913	195208	None	0	Human	Functional	pEC50	=	5.3	5.3	-6	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	432	8	1	2	5.3	CN(C)C(=O)C(CCN[C@@H]1C[C@H]1c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	44443902	94500	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	207	2	1	3	1.8	CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL251215	94500	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	207	2	1	3	1.8	CCN1CCOC(c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	164937988	195320	None	4	Human	Functional	pEC50	=	5.3	5.3	-407	5	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5400876	195320	None	4	Human	Functional	pEC50	=	5.3	5.3	-407	5	Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAgonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	24936042	157681	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4080762	157681	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	24936042	157681	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4080762	157681	None	0	Human	Functional	pEC50	=	7.3	7.3	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	90644226	111842	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287395	111842	None	0	Human	Functional	pEC50	=	7.3	7.3	7	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	172313129	196051	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	506	9	0	6	5.3	CCC1(CC)CC(OCCCN2CCN(c3cccc(C(F)(F)F)n3)CC2)(c2ccccn2)CCO1	10.1021/acs.jmedchem.3c00417
	CHEMBL5415842	196051	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	506	9	0	6	5.3	CCC1(CC)CC(OCCCN2CCN(c3cccc(C(F)(F)F)n3)CC2)(c2ccccn2)CCO1	10.1021/acs.jmedchem.3c00417
	90644226	111842	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	CHEMBL3287395	111842	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
	127047593	140118	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	457	6	1	4	5.2	O=C(NCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1cccc2ccccc12	10.1039/C5MD00590F
	CHEMBL3800194	140118	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	457	6	1	4	5.2	O=C(NCCCN1CCN(c2ccccc2C(F)(F)F)CC1)Oc1cccc2ccccc12	10.1039/C5MD00590F
	172439032	195309	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	412	4	0	3	3.9	CN(C)C(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5400528	195309	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	412	4	0	3	3.9	CN(C)C(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	172439032	195309	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	412	4	0	3	3.9	CN(C)C(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5400528	195309	None	0	Human	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysisAgonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins by BRET analysis	ChEMBL	412	4	0	3	3.9	CN(C)C(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	122181331	121938	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	414	9	1	3	5.4	CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590082	121938	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	414	9	1	3	5.4	CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	681	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	681.0	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	940	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	947	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.2	8.2	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
	90466573	158628	None	0	Human	Functional	pEC50	=	8.2	8.2	16	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4091498	158628	None	0	Human	Functional	pEC50	=	8.2	8.2	16	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	90466573	158628	None	0	Human	Functional	pEC50	=	8.2	8.2	16	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4091498	158628	None	0	Human	Functional	pEC50	=	8.2	8.2	16	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	526	8	2	5	5.1	NC(=O)c1cccc(-c2ccc(OC(=O)NCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)c1	10.1021/acs.jmedchem.6b01578
	127047319	140019	None	0	Human	Functional	pEC50	=	8.2	8.2	6	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	421	7	1	4	4.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccccc1	10.1039/C5MD00590F
	CHEMBL3799603	140019	None	0	Human	Functional	pEC50	=	8.2	8.2	6	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	421	7	1	4	4.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccccc1	10.1039/C5MD00590F
	9826580	206431	None	4	Human	Functional	pEC50	=	8.2	8.2	14	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL69451	206431	None	4	Human	Functional	pEC50	=	8.2	8.2	14	2	Agonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAgonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	9826580	206431	None	4	Human	Functional	pEC50	=	8.2	8.2	14	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1016/s0960-894x(03)00389-5
	CHEMBL69451	206431	None	4	Human	Functional	pEC50	=	8.2	8.2	14	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1016/s0960-894x(03)00389-5
	85470564	156915	None	0	Human	Functional	pEC50	=	8.2	8.2	37	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4071240	156915	None	0	Human	Functional	pEC50	=	8.2	8.2	37	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	540	9	2	5	5.5	NC(=O)c1cccc(-c2cccc(OC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)c2)c1	10.1021/acs.jmedchem.6b01578
	127045795	140196	None	0	Human	Functional	pEC50	=	8.2	8.2	50	2	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	515	8	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(C(=O)O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3798504	140196	None	0	Human	Functional	pEC50	=	8.2	8.2	50	2	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	515	8	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(C(=O)O)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800681	140196	None	0	Human	Functional	pEC50	=	8.2	8.2	50	2	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	515	8	2	5	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(C(=O)O)c2ccccc12	10.1039/C5MD00590F
	127045796	140197	None	0	Human	Functional	pEC50	=	8.2	8.2	39	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	514	8	2	5	4.9	NC(=O)c1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3798211	140197	None	0	Human	Functional	pEC50	=	8.2	8.2	39	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	514	8	2	5	4.9	NC(=O)c1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	CHEMBL3800682	140197	None	0	Human	Functional	pEC50	=	8.2	8.2	39	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	514	8	2	5	4.9	NC(=O)c1ccc(OC(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c2ccccc12	10.1039/C5MD00590F
	127047640	140149	None	0	Human	Functional	pEC50	=	8.2	8.2	28	2	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	460	7	2	4	5.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]ccc12	10.1039/C5MD00590F
	CHEMBL3800421	140149	None	0	Human	Functional	pEC50	=	8.2	8.2	28	2	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	460	7	2	4	5.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]ccc12	10.1039/C5MD00590F
	90467020	158213	None	0	Human	Functional	pEC50	=	8.2	8.2	8	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4086944	158213	None	0	Human	Functional	pEC50	=	8.2	8.2	8	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	11518173	58521	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	7	1	3	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2ccccc12	10.1021/jm050729o
	CHEMBL168357	58521	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	7	1	3	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2ccccc12	10.1021/jm050729o
	168679651	195904	None	2	Human	Functional	pEC50	=	6.2	6.2	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	428	9	1	3	4.6	COc1ccccc1[C@@H]1C[C@H]1NCCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5412995	195904	None	2	Human	Functional	pEC50	=	6.2	6.2	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	428	9	1	3	4.6	COc1ccccc1[C@@H]1C[C@H]1NCCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	137644966	158586	None	0	Human	Functional	pEC50	=	7.2	7.2	14	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	CHEMBL4091064	158586	None	0	Human	Functional	pEC50	=	7.2	7.2	14	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
	11533234	58972	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	487	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)[C@H]1CC[C@@H](c2ccccc2)CC1	10.1021/jm050729o
	CHEMBL168948	58972	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	487	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)[C@H]1CC[C@@H](c2ccccc2)CC1	10.1021/jm050729o
	137636460	156211	None	0	Human	Functional	pEC50	=	7.2	7.2	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4063282	156211	None	0	Human	Functional	pEC50	=	7.2	7.2	9	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
	25071066	111837	None	0	Human	Functional	pEC50	=	7.2	7.2	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl	10.1021/jm5004039
	CHEMBL3287390	111837	None	0	Human	Functional	pEC50	=	7.2	7.2	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl	10.1021/jm5004039
	25071066	111837	None	0	Human	Functional	pEC50	=	7.2	7.2	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl	10.1021/jm5004039
	CHEMBL3287390	111837	None	0	Human	Functional	pEC50	=	7.2	7.2	2	2	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	418	7	0	5	4.6	Clc1cccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c1Cl	10.1021/jm5004039
	44438237	93712	None	1	Human	Functional	pEC50	=	6.2	6.2	-3	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	424	8	1	3	6.4	CCCCCCn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21	10.1016/j.bmcl.2006.10.076
	CHEMBL246855	93712	None	1	Human	Functional	pEC50	=	6.2	6.2	-3	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	424	8	1	3	6.4	CCCCCCn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21	10.1016/j.bmcl.2006.10.076
	24837518	157854	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	312	3	0	1	6.4	CCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	CHEMBL4082631	157854	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	312	3	0	1	6.4	CCCC(C)(C)c1ccc2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21	10.1021/acs.jmedchem.6b01578
	168273745	192917	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5178472	192917	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5221451	192917	None	0	Human	Functional	pEC50	=	7.2	7.2	-4	3	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	332	6	4	4	1.5	N/C(=N\C(=O)NCc1ccccc1)NCCCc1cnc(N)s1	10.1021/acs.jmedchem.1c00692
	90466716	161097	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4099236	161097	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4116199	161097	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	502	10	2	6	4.2	COc1ccccc1N1CCN(CCCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	122181330	121937	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590081	121937	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	10457321	102126	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Compound was evaluated for effective concentration required for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsCompound was evaluated for effective concentration required for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	467	6	1	4	4.2	COc1c(C(=O)NCCN2CCN(c3ccccc3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL30208	102126	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Compound was evaluated for effective concentration required for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsCompound was evaluated for effective concentration required for stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	467	6	1	4	4.2	COc1c(C(=O)NCCN2CCN(c3ccccc3)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	15232475	100655	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	495	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(C)c3C)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL29182	100655	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	495	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3cccc(C)c3C)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	137657115	159849	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4105030	159849	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	228	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	33	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	6005	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	6005.0	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	CHEMBL53	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	DB00714	445	None	20	Human	Functional	pEC50	=	8.2	8.2	-11	20	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2007.10.059
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human D3 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2016.08.021
	127046595	140068	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	457	6	1	4	5.4	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2ccccc12	10.1039/C5MD00590F
	CHEMBL3799902	140068	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	457	6	1	4	5.4	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2ccccc12	10.1039/C5MD00590F
	90466717	157002	None	0	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	CHEMBL4072282	157002	None	0	Human	Functional	pEC50	=	8.1	8.1	5	2	Agonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assayAgonist activity at recombinant human dopamine D3 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 30 mins by HTRF assay	ChEMBL	488	9	2	6	3.8	COc1ccccc1N1CCN(CCCNC(=O)Oc2ccc(-c3cccc(C(N)=O)c3)cc2)CC1	10.1021/acs.jmedchem.6b01578
	127046016	140200	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	461	7	2	5	4.6	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]cnc12	10.1039/C5MD00590F
	CHEMBL3798331	140200	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	461	7	2	5	4.6	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]cnc12	10.1039/C5MD00590F
	CHEMBL3800685	140200	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	461	7	2	5	4.6	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2[nH]cnc12	10.1039/C5MD00590F
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysisAgonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.03.059
	25071385	159250	None	0	Human	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098236	159250	None	0	Human	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	4420454	56275	None	2	Human	Functional	pEC50	=	8.1	8.1	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm800895v
	CHEMBL162762	56275	None	2	Human	Functional	pEC50	=	8.1	8.1	-	1	Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseIntrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP release	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm800895v
	25071385	159250	None	0	Human	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4098236	159250	None	0	Human	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	137657115	159849	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4105030	159849	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	137658100	159710	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4103339	159710	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	137658100	159710	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4103339	159710	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	483	7	1	4	6.0	O=C(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.6b01578
	164626153	186484	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
	CHEMBL4875600	186484	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	378	6	4	4	2.5	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1	10.1016/j.ejmech.2021.113190
	CHEMBL5085974	217493	None	0	Human	Functional	pEC50	=	6.1	6.1	-11	2	Agonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assayAgonist activity at human dopamine D3 receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated for 5 mins with coelenterazine followed by compound addition and measured after 10 mins by BRET assay	ChEMBL		None	None	None		CN(C)C(=O)C(CCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.1c00611
	127047461	140174	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.6	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1CCCC2	10.1039/C5MD00590F
	CHEMBL3800575	140174	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assayAgonist activity at human dopamine D3 receptor expressed in CHOK1 cells assessed as cAMP levels preincubated for 10 mins followed by addition of adenylyl cyclase activator NKH 477 measured after 45 mins by HTRF functional assay	ChEMBL	475	7	1	4	5.6	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)Oc1cccc2c1CCCC2	10.1039/C5MD00590F
	164916967	195989	None	2	Human	Functional	pEC50	=	7.1	7.1	45	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5414796	195989	None	2	Human	Functional	pEC50	=	7.1	7.1	45	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	122181331	121938	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	414	9	1	3	5.4	CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590082	121938	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assayActivation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation counting based myo-[3H]inositol phosphate accumulation assay	ChEMBL	414	9	1	3	5.4	CCCN(CCCCNC(=O)/N=N/c1ccc(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	137643951	158351	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4088639	158351	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
	9794475	94339	None	10	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCO[C@H](c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	CHEMBL250403	94339	None	10	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	221	3	1	3	2.2	CCCN1CCO[C@H](c2cccc(O)c2)C1	10.1016/j.bmcl.2007.10.059
	2	3261	None	19	Human	Functional	pEC50	=	8.1	8.1	2	7	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm301258w
	54562	3261	None	19	Human	Functional	pEC50	=	8.1	8.1	2	7	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm301258w
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.1	8.1	2	7	Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAgonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm301258w
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS bindingActivity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.031
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S bindingAgonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm070860r
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS bindingAgonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm701524h
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingAgonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm901184n
	681	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	681.0	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	940	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	947	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.1	8.1	-2	15	Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm300268s
	168290815	193082	None	0	Human	Functional	pEC50	=	6.1	6.1	-10	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5200771	193082	None	0	Human	Functional	pEC50	=	6.1	6.1	-10	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222529	193082	None	0	Human	Functional	pEC50	=	6.1	6.1	-10	2	Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayAgonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assay	ChEMBL	327	9	4	5	1.2	CCCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	15232476	102121	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3ccccc3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	CHEMBL30206	102121	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Stimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cellsStimulation of mitogenesis in Dopamine receptor D3 transfected CHO p-5 cells	ChEMBL	501	6	1	4	4.8	COc1c(C(=O)NCCN2CCN(c3ccccc3Cl)CC2)cc(Br)c2ccccc12	10.1016/0960-894X(96)00231-4
	25141536	56264	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	587	7	2	5	4.6	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	CHEMBL1627318	56264	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesisAgonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis	ChEMBL	587	7	2	5	4.6	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	27842480	172519	None	29	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	379	6	1	4	3.0	COc1ccc(OCCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)cc1	10.1021/acs.jmedchem.0c00424
	CHEMBL4476784	172519	None	29	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assayAgonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay	ChEMBL	379	6	1	4	3.0	COc1ccc(OCCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)cc1	10.1021/acs.jmedchem.0c00424
	44443901	155083	None	22	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	179	1	2	3	1.1	Oc1cccc(C2CNCCO2)c1	10.1016/j.bmcl.2007.10.059
	CHEMBL401328	155083	None	22	Human	Functional	pEC50	=	6.1	6.1	8	2	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationAgonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	179	1	2	3	1.1	Oc1cccc(C2CNCCO2)c1	10.1016/j.bmcl.2007.10.059
	154725484	176570	None	1	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4439544	176570	None	1	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4596514	176570	None	1	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	164624107	185828	None	0	Human	Functional	pEC50	=	6.1	6.1	-8	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
	CHEMBL4865765	185828	None	0	Human	Functional	pEC50	=	6.1	6.1	-8	3	Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayAgonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay	ChEMBL	402	9	4	4	2.8	Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1	10.1016/j.ejmech.2021.113190
	44400519	133197	None	0	Human	Functional	pEC50	=	8.0	8.0	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL370297	133197	None	0	Human	Functional	pEC50	=	8.0	8.0	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	90467020	158213	None	0	Human	Functional	pEC50	=	8.0	8.0	8	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4086944	158213	None	0	Human	Functional	pEC50	=	8.0	8.0	8	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	90467020	158213	None	0	Human	Functional	pEC50	=	8.0	8.0	8	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	CHEMBL4086944	158213	None	0	Human	Functional	pEC50	=	8.0	8.0	8	2	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	556	8	2	5	5.4	NC(=O)c1cccc(-c2ccc(OC(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2F)c1	10.1021/acs.jmedchem.6b01578
	681	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	681.0	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	940	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	947	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	681	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	681.0	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	940	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	947	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	CHEMBL59	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	DB00988	1465	None	47	Human	Functional	pEC50	=	8.0	8.0	-2	15	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm5004039
	137644833	158231	None	0	Human	Functional	pEC50	=	8.0	8.0	95	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4087187	158231	None	0	Human	Functional	pEC50	=	8.0	8.0	95	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	137644833	158231	None	0	Human	Functional	pEC50	=	8.0	8.0	95	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	CHEMBL4087187	158231	None	0	Human	Functional	pEC50	=	8.0	8.0	95	2	Agonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assayAgonist activity at human Dopamine D3 receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 mins by [35S]GTPgammaS binding assay	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
	2	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	54562	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	2	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	54562	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	CHEMBL240773	3261	None	19	Human	Functional	pEC50	=	8.0	8.0	2	7	Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assayAgonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
	164619170	185707	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164916967	195989	None	2	Human	Functional	pEC50	=	8.0	8.0	45	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5414796	195989	None	2	Human	Functional	pEC50	=	8.0	8.0	45	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	44400553	70803	None	0	Human	Functional	pEC50	=	8.0	8.0	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	CHEMBL195083	70803	None	0	Human	Functional	pEC50	=	8.0	8.0	2	2	Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorEffective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptor	ChEMBL		None	None	None		None	10.1021/jm050170s
	5311189	207299	None	9	Human	Functional	pEC50	=	8.0	8.0	2	4	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	10.1016/s0960-894x(02)00390-6
	CHEMBL7549	207299	None	9	Human	Functional	pEC50	=	8.0	8.0	2	4	Effective concentration required for agonistic activity against human D3 receptorEffective concentration required for agonistic activity against human D3 receptor	ChEMBL	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	10.1016/s0960-894x(02)00390-6
	164619170	185707	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	CHEMBL4863832	185707	None	0	Human	Functional	pEC50	=	8.0	8.0	-10	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recruitment preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	396	9	2	4	3.8	COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1	10.1021/acs.jmedchem.1c01327
	164916967	195989	None	2	Human	Functional	pEC50	=	8.0	8.0	45	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5414796	195989	None	2	Human	Functional	pEC50	=	8.0	8.0	45	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	133633	2241	None	40	Human	Functional	pEC50	=	7.0	7.0	-20	4	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1016/j.bmcl.2006.10.076
	177	2241	None	40	Human	Functional	pEC50	=	7.0	7.0	-20	4	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1016/j.bmcl.2006.10.076
	CHEMBL445102	2241	None	40	Human	Functional	pEC50	=	7.0	7.0	-20	4	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1016/j.bmcl.2006.10.076
	172441436	195050	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	670	13	1	7	5.2	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2nsc3ccccc23)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5395539	195050	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	670	13	1	7	5.2	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2nsc3ccccc23)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	90467452	158532	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4090459	158532	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	90467452	158532	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	CHEMBL4090459	158532	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	ChEMBL	489	10	1	6	5.1	COc1cc(OC(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1-c1ccccc1	10.1021/acs.jmedchem.6b01578
	164619127	185631	None	0	Human	Functional	pEC50	=	7.0	7.0	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.0	7.0	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	164619127	185631	None	0	Human	Functional	pEC50	=	7.0	7.0	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	CHEMBL4862770	185631	None	0	Human	Functional	pEC50	=	7.0	7.0	-11	3	Partial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assayPartial agonist activity at D3 receptor (unknown origin) expressed in HEK293T cells co-expressing GalphaoA preincubated for 2 mins with coelenterazine followed by compound addition and measured after 2 mins by BRET assay	ChEMBL	428	10	2	4	4.8	COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2c(c1)NC(=O)CC2	10.1021/acs.jmedchem.1c01327
	168475887	195235	None	2	Human	Functional	pEC50	=	7.0	7.0	10	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL5399270	195235	None	2	Human	Functional	pEC50	=	7.0	7.0	10	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	168475887	195235	None	2	Human	Functional	pEC50	=	7.0	7.0	10	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL5399270	195235	None	2	Human	Functional	pEC50	=	7.0	7.0	10	2	Partial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assayPartial agonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	44438236	154990	None	1	Human	Functional	pEC50	=	7.0	7.0	-4	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	1	3	4.3	Cn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21	10.1016/j.bmcl.2006.10.076
	CHEMBL400827	154990	None	1	Human	Functional	pEC50	=	7.0	7.0	-4	2	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis	ChEMBL	354	3	1	3	4.3	Cn1cc(CN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21	10.1016/j.bmcl.2006.10.076
	154706030	176650	None	1	Human	Functional	pEC50	=	7	7.0	35	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4580817	176650	None	1	Human	Functional	pEC50	=	7	7.0	35	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	CHEMBL4597188	176650	None	1	Human	Functional	pEC50	=	7	7.0	35	2	Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assayAgonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation preincubated for 15 mins followed by isoproterenol addition by Glosensor-based luminescence assay	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
	9888555	165699	None	19	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL424294	165699	None	19	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	73671217	113750	None	0	Human	Functional	pIC50	=	9.5	9.5	27	2	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	504	7	1	8	3.2	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cn4ccncc4n3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	CHEMBL3323016	113750	None	0	Human	Functional	pIC50	=	9.5	9.5	27	2	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	504	7	1	8	3.2	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cn4ccncc4n3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	25130157	103362	None	0	Human	Functional	pIC50	=	9.1	9.1	2	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
	CHEMBL3084515	103362	None	0	Human	Functional	pIC50	=	9.1	9.1	2	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
	44427820	93252	None	0	Human	Functional	pIC50	=	9	9.0	40	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	496	7	2	4	4.5	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccc(=O)[nH]2)cc1	10.1021/jm0704200
	CHEMBL244562	93252	None	0	Human	Functional	pIC50	=	9	9.0	40	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	496	7	2	4	4.5	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccc(=O)[nH]2)cc1	10.1021/jm0704200
	11223885	70723	None	0	Human	Functional	pIC50	=	9	9.0	8	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	419	6	2	4	3.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(O)cc1	10.1021/jm040190e
	CHEMBL195057	70723	None	0	Human	Functional	pIC50	=	9	9.0	8	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	419	6	2	4	3.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(O)cc1	10.1021/jm040190e
	42625207	56250	None	0	Human	Functional	pIC50	=	9.0	9.0	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL1627304	56250	None	0	Human	Functional	pIC50	=	9.0	9.0	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	44427823	93276	None	0	Human	Functional	pIC50	=	8.9	8.9	60	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	496	7	1	4	4.4	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccc[n+]2[O-])cc1	10.1021/jm0704200
	CHEMBL244774	93276	None	0	Human	Functional	pIC50	=	8.9	8.9	60	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	496	7	1	4	4.4	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2cccc[n+]2[O-])cc1	10.1021/jm0704200
	66574145	113745	None	0	Human	Functional	pIC50	=	8.9	8.9	81	2	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cn4ccccc4n3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	CHEMBL3323011	113745	None	0	Human	Functional	pIC50	=	8.9	8.9	81	2	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cn4ccccc4n3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	86342156	149686	None	0	Human	Functional	pIC50	=	8.9	8.9	22	4	Antagonistic activity at D3 receptor (unknown origin) expressed in cell membranes assessed as inhibition of quinpirole-induced response after 40 mins by [35S]GTPgammaS binding assayAntagonistic activity at D3 receptor (unknown origin) expressed in cell membranes assessed as inhibition of quinpirole-induced response after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	438	6	1	6	4.4	O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1	10.1016/j.ejmech.2016.07.038
	CHEMBL3946995	149686	None	0	Human	Functional	pIC50	=	8.9	8.9	22	4	Antagonistic activity at D3 receptor (unknown origin) expressed in cell membranes assessed as inhibition of quinpirole-induced response after 40 mins by [35S]GTPgammaS binding assayAntagonistic activity at D3 receptor (unknown origin) expressed in cell membranes assessed as inhibition of quinpirole-induced response after 40 mins by [35S]GTPgammaS binding assay	ChEMBL	438	6	1	6	4.4	O=C(N[C@H]1CC[C@H](CCN2CCN(c3nsc4ccccc34)CC2)CC1)c1ccco1	10.1016/j.ejmech.2016.07.038
	42626172	56260	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	490	8	3	5	3.8	COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm900095y
	CHEMBL1627314	56260	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	490	8	3	5	3.8	COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm900095y
	42626381	56261	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	452	9	3	6	2.5	COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm900095y
	CHEMBL1627315	56261	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	452	9	3	6	2.5	COc1ccc2[nH]c(C(=O)NCCC(O)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm900095y
	25141538	56257	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627311	56257	None	0	Human	Functional	pIC50	=	8.8	8.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
	3038495	708	None	33	Human	Functional	pIC50	=	8.7	8.7	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	7625	708	None	33	Human	Functional	pIC50	=	8.7	8.7	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	CHEMBL25236	708	None	33	Human	Functional	pIC50	=	8.7	8.7	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	172454491	195657	None	0	Human	Functional	pIC50	=	8.7	8.7	3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	421	8	1	4	3.7	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)COC)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL5408223	195657	None	0	Human	Functional	pIC50	=	8.7	8.7	3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	421	8	1	4	3.7	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)COC)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	172454491	195657	None	0	Human	Functional	pIC50	=	8.7	8.7	3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	421	8	1	4	3.7	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)COC)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL5408223	195657	None	0	Human	Functional	pIC50	=	8.7	8.7	3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	421	8	1	4	3.7	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)COC)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	11154555	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	11154555.0	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	5037	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	7671	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL2028019	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL3085826	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	DB06016	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	25132869	103350	None	0	Human	Functional	pIC50	=	8.0	8.0	20	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	CHEMBL3084503	103350	None	0	Human	Functional	pIC50	=	8.0	8.0	20	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	42626313	56263	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	423	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	CHEMBL1627317	56263	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	423	8	2	6	2.7	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	44309688	206450	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2	10.1021/jm040190e
	CHEMBL69571	206450	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc2c1-c1ccccc1C2	10.1021/jm040190e
	53248260	62059	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	454	9	2	5	3.5	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774540	62059	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	454	9	2	5	3.5	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	172464337	196969	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5435745	196969	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	25141535	56254	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	422	8	3	5	2.5	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627308	56254	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	422	8	3	5	2.5	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	172464337	196969	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5435745	196969	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	427	7	0	4	3.8	COCCC(=O)N1CCC(CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	25129807	103349	None	0	Human	Functional	pIC50	=	7.9	7.9	3	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	CHEMBL3084502	103349	None	0	Human	Functional	pIC50	=	7.9	7.9	3	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
	44427831	92291	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	460	9	2	6	3.1	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	CHEMBL242644	92291	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	460	9	2	6	3.1	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	171492372	197072	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5438081	197072	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	171492372	197072	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5438081	197072	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	0	4	4.2	COCCC(=O)N1CCC(CCCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	53248213	62054	None	0	Human	Functional	pIC50	=	5.9	5.9	2	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	CHEMBL1774535	62054	None	0	Human	Functional	pIC50	=	5.9	5.9	2	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	53248210	62051	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774532	62051	None	0	Human	Functional	pIC50	=	5.9	5.9	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	164937996	197036	None	0	Human	Functional	pIC50	=	4.9	4.9	-977	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccnc(N2CCN(CCCc3nc4ccccc4s3)CC2)c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5437265	197036	None	0	Human	Functional	pIC50	=	4.9	4.9	-977	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccnc(N2CCN(CCCc3nc4ccccc4s3)CC2)c1	10.1021/acs.jmedchem.3c00734
	37459	746	None	9	Human	Functional	pIC50	=	7.9	7.9	-13	4	Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysisAntagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/acs.jmedchem.3c00976
	62	746	None	9	Human	Functional	pIC50	=	7.9	7.9	-13	4	Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysisAntagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/acs.jmedchem.3c00976
	CHEMBL8514	746	None	9	Human	Functional	pIC50	=	7.9	7.9	-13	4	Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysisAntagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/acs.jmedchem.3c00976
	172454049	195686	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	450	7	1	4	4.3	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5409134	195686	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	450	7	1	4	4.3	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	172454049	195686	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	450	7	1	4	4.3	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5409134	195686	None	0	Human	Functional	pIC50	=	7.9	7.9	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	450	7	1	4	4.3	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)N(C)C)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	42625290	56262	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL1627316	56262	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	461	7	2	5	4.0	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	164938002	194980	None	0	Human	Functional	pIC50	=	4.9	4.9	-218	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	351	5	0	4	4.8	Cc1cccnc1C1CCN(CCCc2nc3ccccc3s2)CC1	10.1021/acs.jmedchem.3c00734
	CHEMBL5394387	194980	None	0	Human	Functional	pIC50	=	4.9	4.9	-218	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	351	5	0	4	4.8	Cc1cccnc1C1CCN(CCCc2nc3ccccc3s2)CC1	10.1021/acs.jmedchem.3c00734
	44427841	86173	None	0	Human	Functional	pIC50	=	7.8	7.8	21	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.2	O=C(NC[C@H]1C[C@@H]1CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL231156	86173	None	0	Human	Functional	pIC50	=	7.8	7.8	21	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.2	O=C(NC[C@H]1C[C@@H]1CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	6674	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	9891901	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	CHEMBL300780	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	6674	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	9891901	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	CHEMBL300780	2817	None	23	Human	Functional	pIC50	=	7.8	7.8	151	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	42625293	56265	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	CHEMBL1627319	56265	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	42625205	56270	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	CHEMBL1627324	56270	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	11696813	188024	None	9	Human	Functional	pIC50	=	6.8	6.8	5	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
	CHEMBL496739	188024	None	9	Human	Functional	pIC50	=	6.8	6.8	5	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
	53248211	62052	None	0	Human	Functional	pIC50	=	5.8	5.8	1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	493	8	1	5	5.0	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774533	62052	None	0	Human	Functional	pIC50	=	5.8	5.8	1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	493	8	1	5	5.0	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm200288r
	60165418	75375	None	0	Human	Functional	pIC50	=	5.8	5.8	-9	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL2037521	75375	None	0	Human	Functional	pIC50	=	5.8	5.8	-9	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	353	6	0	6	3.2	c1cnc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	168475866	196686	None	2	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	455	11	2	6	5.1	CCCCCCOc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OCCOCC)c3CN1CC2	10.1021/acs.jmedchem.3c00976
	CHEMBL5429932	196686	None	2	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	455	11	2	6	5.1	CCCCCCOc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OCCOCC)c3CN1CC2	10.1021/acs.jmedchem.3c00976
	56852956	112106	None	1	Human	Functional	pIC50	=	4.8	4.8	-281	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL3289656	112106	None	1	Human	Functional	pIC50	=	4.8	4.8	-281	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5075990	216895	None	0	Human	Functional	pIC50	=	5.8	5.8	-2	2	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL		None	None	None		CCc1cc(Cl)c(OC)c(C(=O)NCC2CCCN2CCCCNCCC(C(=O)N(C)C)(c2ccccc2)c2ccccc2)c1O	10.1021/acs.jmedchem.1c00611
	164938010	195433	None	0	Human	Functional	pIC50	=	4.8	4.8	-117	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccc2nc(CCCN3CCN(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5403610	195433	None	0	Human	Functional	pIC50	=	4.8	4.8	-117	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	352	5	0	5	3.8	Cc1ccc2nc(CCCN3CCN(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	37459	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levelsAntagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levels	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.ejmech.2014.12.045
	62	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levelsAntagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levels	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.ejmech.2014.12.045
	CHEMBL8514	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levelsAntagonist activity against human recombinant dopmaine D3 receptor expressed in CHOK1 cells assessed as reduction in dopamine-induced cAMP levels	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.ejmech.2014.12.045
	37459	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/jm401895u
	62	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/jm401895u
	CHEMBL8514	746	None	9	Human	Functional	pIC50	=	7.8	7.8	-13	4	Antagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D3 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1021/jm401895u
	53248259	62058	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	479	7	1	4	5.5	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm200288r
	CHEMBL1774539	62058	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	479	7	1	4	5.5	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm200288r
	172459790	196485	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	465	10	1	5	4.1	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)CCOC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5424897	196485	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	465	10	1	5	4.1	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)CCOC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	172459790	196485	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	465	10	1	5	4.1	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)CCOC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5424897	196485	None	0	Human	Functional	pIC50	=	7.8	7.8	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	465	10	1	5	4.1	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)CCOC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	42626380	56259	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	548	8	3	5	3.1	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627313	56259	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	548	8	3	5	3.1	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3[nH]2)CC1	10.1021/jm900095y
	44309775	102733	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm040190e
	CHEMBL304605	102733	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	491	6	1	3	5.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm040190e
	172444851	195152	None	0	Human	Functional	pIC50	=	5.8	5.8	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	474	10	0	2	6.4	CCCN(CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1)[C@@H]1C[C@H]1c1ccc(Cl)cc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5397609	195152	None	0	Human	Functional	pIC50	=	5.8	5.8	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	474	10	0	2	6.4	CCCN(CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1)[C@@H]1C[C@H]1c1ccc(Cl)cc1	10.1021/acs.jmedchem.3c00417
	42626318	56252	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627306	56252	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC[C@@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	11408148	128788	None	0	Human	Functional	pIC50	=	7.7	7.7	5	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL366904	128788	None	0	Human	Functional	pIC50	=	7.7	7.7	5	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	11408148	128788	None	0	Human	Functional	pIC50	=	7.7	7.7	5	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm040190e
	CHEMBL366904	128788	None	0	Human	Functional	pIC50	=	7.7	7.7	5	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm040190e
	44427826	93326	None	0	Human	Functional	pIC50	=	7.7	7.7	9	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	453	7	1	4	4.4	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm0704200
	CHEMBL244989	93326	None	0	Human	Functional	pIC50	=	7.7	7.7	9	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	453	7	1	4	4.4	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm0704200
	73670899	113779	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	545	8	1	5	5.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)[C@H]3CC[C@H](c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	CHEMBL3323117	113779	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assayAntagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay	ChEMBL	545	8	1	5	5.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)[C@H]3CC[C@H](c4ccccc4)CC3)CC2)cc(C(F)(F)F)n1	10.1021/jm500801r
	172468596	197053	None	0	Human	Functional	pIC50	=	7.7	7.7	-3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	436	7	2	4	3.9	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)NC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5437660	197053	None	0	Human	Functional	pIC50	=	7.7	7.7	-3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	436	7	2	4	3.9	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)NC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	172468596	197053	None	0	Human	Functional	pIC50	=	7.7	7.7	-3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	436	7	2	4	3.9	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)NC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5437660	197053	None	0	Human	Functional	pIC50	=	7.7	7.7	-3	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	436	7	2	4	3.9	CCc1cc(Cl)c(OC)c(N2CCN(CC[C@H]3CC[C@H](NC(=O)NC)CC3)CC2)c1	10.1021/acs.jmedchem.2c01624
	CHEMBL5080654	217186	None	0	Human	Functional	pIC50	=	5.7	5.7	-134	2	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL		None	None	None		CCOC(=O)/C=C1\[C@@H]2CCC[C@@]1(c1cccc(O)c1)CCN2CCc1ccccc1	10.1021/acs.jmedchem.1c00611
	11154555	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	11154555.0	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	5037	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	7671	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL2028019	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL3085826	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	DB06016	800	None	50	Human	Functional	pIC50	=	8.7	8.7	-1	10	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.2c01624
	11676873	9197	None	0	Human	Functional	pIC50	=	8.7	8.7	21	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	455	8	1	4	4.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm0704200
	CHEMBL110365	9197	None	0	Human	Functional	pIC50	=	8.7	8.7	21	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	455	8	1	4	4.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm0704200
	11316847	70371	None	0	Human	Functional	pIC50	=	8.7	8.7	6	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm040190e
	CHEMBL194493	70371	None	0	Human	Functional	pIC50	=	8.7	8.7	6	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	448	7	1	5	4.0	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm040190e
	10092819	16780	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	CHEMBL124444	16780	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
	1353	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	3559	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	3559.0	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	86	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL54	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	DB00502	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	1353	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	3559	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	3559.0	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	86	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL54	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	DB00502	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.2c01624
	1353	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	3559	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	3559.0	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	86	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL54	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	DB00502	1911	None	63	Human	Functional	pIC50	=	8.6	8.6	2	39	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.3c00417
	44427818	92157	None	0	Human	Functional	pIC50	=	8.5	8.5	38	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	444	9	1	5	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	CHEMBL241973	92157	None	0	Human	Functional	pIC50	=	8.5	8.5	38	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	444	9	1	5	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	53248256	62055	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	473	8	1	4	4.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm200288r
	CHEMBL1774536	62055	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	473	8	1	4	4.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc3c(c2)Cc2ccccc2-3)CC1	10.1021/jm200288r
	25141536	56264	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	587	7	2	5	4.6	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	CHEMBL1627318	56264	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	587	7	2	5	4.6	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	44393403	65099	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	CHEMBL182379	65099	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
	164937988	195320	None	4	Human	Functional	pIC50	=	4.7	4.7	-407	5	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5400876	195320	None	4	Human	Functional	pIC50	=	4.7	4.7	-407	5	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	42626243	56256	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	478	7	3	4	3.9	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(F)ccc2[nH]1	10.1021/jm900095y
	CHEMBL1627310	56256	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	478	7	3	4	3.9	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(F)ccc2[nH]1	10.1021/jm900095y
	2389	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	5073	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	5073.0	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	96	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	CHEMBL85	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	DB00734	3331	None	72	Human	Functional	pIC50	=	7.6	7.6	-24	29	Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assayAntagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/acs.jmedchem.3c00976
	11307083	63576	None	0	Human	Functional	pIC50	=	7.6	7.6	6	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm040190e
	CHEMBL180060	63576	None	0	Human	Functional	pIC50	=	7.6	7.6	6	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	529	6	1	3	4.7	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm040190e
	164937986	195324	None	0	Human	Functional	pIC50	=	4.6	4.6	-42	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	372	5	0	5	4.1	Clc1ccc2sc(CCCN3CCN(c4ccccn4)CC3)nc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5400983	195324	None	0	Human	Functional	pIC50	=	4.6	4.6	-42	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	372	5	0	5	4.1	Clc1ccc2sc(CCCN3CCN(c4ccccn4)CC3)nc2c1	10.1021/acs.jmedchem.3c00734
	129103318	167410	None	0	Human	Functional	pIC50	=	7.6	7.6	-2	6	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	167410	None	0	Human	Functional	pIC50	=	7.6	7.6	-2	6	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	44427822	93275	None	0	Human	Functional	pIC50	=	7.6	7.6	14	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.5	Cc1cccnc1-c1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm0704200
	CHEMBL244773	93275	None	0	Human	Functional	pIC50	=	7.6	7.6	14	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.5	Cc1cccnc1-c1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm0704200
	42625295	56267	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627321	56267	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	53248298	62061	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	473	7	1	3	5.4	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1	10.1021/jm200288r
	CHEMBL1774542	62061	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	473	7	1	3	5.4	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1	10.1021/jm200288r
	53248159	62009	None	0	Human	Functional	pIC50	=	6.6	6.6	4	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	500	8	1	4	5.3	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm200288r
	CHEMBL1774384	62009	None	0	Human	Functional	pIC50	=	6.6	6.6	4	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	500	8	1	4	5.3	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm200288r
	24769156	116281	None	0	Human	Functional	pIC50	=	6.6	6.6	6	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as reduction in dopamine-induced response by [35S]GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as reduction in dopamine-induced response by [35S]GTPgammaS binding assay	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
	CHEMBL3358509	116281	None	0	Human	Functional	pIC50	=	6.6	6.6	6	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as reduction in dopamine-induced response by [35S]GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as reduction in dopamine-induced response by [35S]GTPgammaS binding assay	ChEMBL	388	7	1	4	3.6	O=C(NCCCCN1CCN(c2ccccc2)CC1)c1ccc2ncccc2c1	10.1021/jm501119j
	44309509	96573	None	0	Human	Functional	pIC50	=	7.6	7.6	2	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	457	7	1	5	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2n1	10.1021/jm040190e
	CHEMBL262724	96573	None	0	Human	Functional	pIC50	=	7.6	7.6	2	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	457	7	1	5	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2n1	10.1021/jm040190e
	44309509	96573	None	0	Human	Functional	pIC50	=	7.6	7.6	2	2	Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAntagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	457	7	1	5	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2n1	10.1016/s0960-894x(03)00389-5
	CHEMBL262724	96573	None	0	Human	Functional	pIC50	=	7.6	7.6	2	2	Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAntagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	457	7	1	5	4.3	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2n1	10.1016/s0960-894x(03)00389-5
	168475887	195235	None	2	Human	Functional	pIC50	=	6.6	6.6	10	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	CHEMBL5399270	195235	None	2	Human	Functional	pIC50	=	6.6	6.6	10	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	419	5	0	4	4.6	Clc1cccc(N2CCN(CCC3(c4ccccn4)CCOCC3)CC2)c1Cl	10.1021/acs.jmedchem.3c00417
	168475888	196855	None	2	Human	Functional	pIC50	=	6.6	6.6	-1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	410	6	1	3	5.6	Clc1ccc([C@@H]2C[C@H]2NCCC2(c3ccccn3)CCOC3(CCCC3)C2)cc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5433458	196855	None	2	Human	Functional	pIC50	=	6.6	6.6	-1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	410	6	1	3	5.6	Clc1ccc([C@@H]2C[C@H]2NCCC2(c3ccccn3)CCOC3(CCCC3)C2)cc1	10.1021/acs.jmedchem.3c00417
	164938006	195571	None	0	Human	Functional	pIC50	=	5.6	5.6	-53	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1cccc2nc(CCCN3CCC(c4ccccn4)CC3)sc12	10.1021/acs.jmedchem.3c00734
	CHEMBL5406300	195571	None	0	Human	Functional	pIC50	=	5.6	5.6	-53	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1cccc2nc(CCCN3CCC(c4ccccn4)CC3)sc12	10.1021/acs.jmedchem.3c00734
	25141534	56251	None	0	Human	Functional	pIC50	=	7.5	7.5	7	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627305	56251	None	0	Human	Functional	pIC50	=	7.5	7.5	7	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	164916968	196909	None	0	Human	Functional	pIC50	=	5.5	5.5	12	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	CHEMBL5434650	196909	None	0	Human	Functional	pIC50	=	5.5	5.5	12	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	618	11	1	6	4.9	CCc1cc(Cl)c(OC)c(N2CCN(C[C@@H]3C[C@@H](O)CN3CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1	10.1021/acs.jmedchem.3c00417
	53248260	62059	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	454	9	2	5	3.5	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774540	62059	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	454	9	2	5	3.5	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	11477180	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	6675	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	CHEMBL180010	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm0704200
	3038495	708	None	33	Human	Functional	pIC50	=	8.5	8.5	-8	8	Partial agonist intrinsic activity at dopamine D3 receptorPartial agonist intrinsic activity at dopamine D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	7625	708	None	33	Human	Functional	pIC50	=	8.5	8.5	-8	8	Partial agonist intrinsic activity at dopamine D3 receptorPartial agonist intrinsic activity at dopamine D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	CHEMBL25236	708	None	33	Human	Functional	pIC50	=	8.5	8.5	-8	8	Partial agonist intrinsic activity at dopamine D3 receptorPartial agonist intrinsic activity at dopamine D3 receptor	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	11477180	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	6675	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	CHEMBL180010	3074	None	4	Human	Functional	pIC50	=	8.5	8.5	26	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	480	7	1	4	5.2	O=C(c1ccc(cc1)c1ccccn1)NC/C=C/CN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	172467420	196886	None	0	Human	Functional	pIC50	=	8.5	8.5	8	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	442	8	1	5	3.3	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5434229	196886	None	0	Human	Functional	pIC50	=	8.5	8.5	8	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	442	8	1	5	3.3	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1	10.1021/acs.jmedchem.2c01624
	172467420	196886	None	0	Human	Functional	pIC50	=	8.5	8.5	8	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	442	8	1	5	3.3	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5434229	196886	None	0	Human	Functional	pIC50	=	8.5	8.5	8	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	442	8	1	5	3.3	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1	10.1021/acs.jmedchem.2c01624
	1353	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	3559	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	3559.0	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	86	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	CHEMBL54	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	DB00502	1911	None	63	Human	Functional	pIC50	=	8.5	8.5	2	39	Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assayAntagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-PBS for 3 hrs followed by coelenterazine addition for 5 mins once again compound addition for 10 mins by BRET assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.1c00611
	44309510	102177	None	0	Human	Functional	pIC50	=	7.5	7.5	1	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	531	7	1	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm040190e
	CHEMBL302374	102177	None	0	Human	Functional	pIC50	=	7.5	7.5	1	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	531	7	1	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)cc1	10.1021/jm040190e
	172449716	195885	None	0	Human	Functional	pIC50	=	6.5	6.5	8	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	682	13	1	6	5.0	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5412606	195885	None	0	Human	Functional	pIC50	=	6.5	6.5	8	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	682	13	1	6	5.0	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	53248261	62060	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	492	8	2	4	4.8	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774541	62060	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	492	8	2	4	4.8	COc1ccc2[nH]c(C(=O)NCCC(F)CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2c1	10.1021/jm200288r
	53248258	62057	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	CHEMBL1774538	62057	None	0	Human	Functional	pIC50	=	5.5	5.5	-1	3	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	171492463	197008	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	511	6	1	5	5.2	O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1)c1ccnc2ccccc12	10.1021/acs.jmedchem.2c01624
	CHEMBL5436641	197008	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	511	6	1	5	5.2	O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1)c1ccnc2ccccc12	10.1021/acs.jmedchem.2c01624
	171492463	197008	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	511	6	1	5	5.2	O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1)c1ccnc2ccccc12	10.1021/acs.jmedchem.2c01624
	CHEMBL5436641	197008	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	511	6	1	5	5.2	O=C(N[C@H]1CC[C@H](CCN2CCN(c3cccc(C(F)(F)F)n3)CC2)CC1)c1ccnc2ccccc12	10.1021/acs.jmedchem.2c01624
	171492376	195452	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	504	7	1	4	6.0	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)c4ccnc5ccccc45)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL5404054	195452	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	504	7	1	4	6.0	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)c4ccnc5ccccc45)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	171492376	195452	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	504	7	1	4	6.0	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)c4ccnc5ccccc45)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	CHEMBL5404054	195452	None	0	Human	Functional	pIC50	=	7.4	7.4	1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	504	7	1	4	6.0	CCc1cccc(N2CCN(CC[C@H]3CC[C@H](NC(=O)c4ccnc5ccccc45)CC3)CC2)c1Cl	10.1021/acs.jmedchem.2c01624
	53248259	62058	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	479	7	1	4	5.5	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm200288r
	CHEMBL1774539	62058	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	479	7	1	4	5.5	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm200288r
	42626171	56258	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	586	7	3	4	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2[nH]1	10.1021/jm900095y
	CHEMBL1627312	56258	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	586	7	3	4	4.4	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2[nH]1	10.1021/jm900095y
	164916930	195492	None	0	Human	Functional	pIC50	=	6.4	6.4	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	680	13	2	7	4.0	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5404724	195492	None	0	Human	Functional	pIC50	=	6.4	6.4	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	680	13	2	7	4.0	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(C(F)(F)F)n2)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	42626315	56266	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	CHEMBL1627320	56266	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
	53248158	62008	None	0	Human	Functional	pIC50	=	6.4	6.4	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	CHEMBL1774383	62008	None	0	Human	Functional	pIC50	=	6.4	6.4	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	25128757	103359	None	0	Human	Functional	pIC50	=	8.4	8.4	6	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
	CHEMBL3084512	103359	None	0	Human	Functional	pIC50	=	8.4	8.4	6	2	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
	169410194	196730	None	6	Human	Functional	pIC50	=	8.3	8.3	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5431103	196730	None	6	Human	Functional	pIC50	=	8.3	8.3	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	169410194	196730	None	6	Human	Functional	pIC50	=	8.3	8.3	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	CHEMBL5431103	196730	None	6	Human	Functional	pIC50	=	8.3	8.3	-1	2	Antagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysisAntagonist activity at D3 receptor in HEK293T cells assessed as G beta-gamma release from G alpha oA using coelenterazine h as substrate pretreated with substrate followed by compound addition measured after 10 mins in presence of quinpirole by BRET analysis	ChEMBL	441	8	1	4	4.2	COCCC(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1	10.1021/acs.jmedchem.2c01624
	11224283	133573	None	0	Human	Functional	pIC50	=	8.3	8.3	12	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	433	7	1	4	4.1	COc1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm040190e
	CHEMBL370713	133573	None	0	Human	Functional	pIC50	=	8.3	8.3	12	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	433	7	1	4	4.1	COc1ccc(C(=O)NC/C=C/CN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1021/jm040190e
	10276451	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL2112910	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL59725	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	10276451	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm040190e
	CHEMBL2112910	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm040190e
	CHEMBL59725	202741	None	32	Human	Functional	pIC50	=	8.3	8.3	19	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm040190e
	44427825	149466	None	0	Human	Functional	pIC50	=	7.4	7.4	4	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	442	8	1	5	3.9	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	CHEMBL394541	149466	None	0	Human	Functional	pIC50	=	7.4	7.4	4	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	442	8	1	5	3.9	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm0704200
	53248209	62011	None	3	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	463	7	1	4	5.0	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm200288r
	CHEMBL1774386	62011	None	3	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	463	7	1	4	5.0	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm200288r
	53248208	62010	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	425	8	1	5	3.7	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm200288r
	CHEMBL1774385	62010	None	0	Human	Functional	pIC50	=	6.4	6.4	-3	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	425	8	1	5	3.7	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm200288r
	172446093	195429	None	0	Human	Functional	pIC50	=	6.3	6.3	-58	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	368	6	0	6	3.5	COc1cccnc1N1CCN(CCCc2nc3ccccc3s2)CC1	10.1021/acs.jmedchem.3c00734
	CHEMBL5403504	195429	None	0	Human	Functional	pIC50	=	6.3	6.3	-58	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	368	6	0	6	3.5	COc1cccnc1N1CCN(CCCc2nc3ccccc3s2)CC1	10.1021/acs.jmedchem.3c00734
	25141534	56251	None	0	Human	Functional	pIC50	=	6.3	6.3	7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	CHEMBL1627305	56251	None	0	Human	Functional	pIC50	=	6.3	6.3	7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	6674	2817	None	23	Human	Functional	pIC50	=	8.3	8.3	151	2	Antagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorAntagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	9891901	2817	None	23	Human	Functional	pIC50	=	8.3	8.3	151	2	Antagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorAntagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	CHEMBL300780	2817	None	23	Human	Functional	pIC50	=	8.3	8.3	151	2	Antagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorAntagonist activity against 100 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm040190e
	44427836	144048	None	0	Human	Functional	pIC50	=	8.3	8.3	20	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	CHEMBL390253	144048	None	0	Human	Functional	pIC50	=	8.3	8.3	20	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	498	8	2	5	4.4	O=C(NCC(O)CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm0704200
	44309876	206329	None	0	Human	Functional	pIC50	=	7.3	7.3	10	2	Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAntagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	462	7	2	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(F)ccc2[nH]1	10.1016/s0960-894x(03)00389-5
	CHEMBL68740	206329	None	0	Human	Functional	pIC50	=	7.3	7.3	10	2	Antagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAntagonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	462	7	2	3	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(F)ccc2[nH]1	10.1016/s0960-894x(03)00389-5
	10438027	66209	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	CHEMBL184383	66209	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
	53248213	62054	None	0	Human	Functional	pIC50	=	6.3	6.3	2	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	CHEMBL1774535	62054	None	0	Human	Functional	pIC50	=	6.3	6.3	2	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	462	7	2	3	4.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm200288r
	172442773	195208	None	0	Human	Functional	pIC50	=	5.3	5.3	-6	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	432	8	1	2	5.3	CN(C)C(=O)C(CCN[C@@H]1C[C@H]1c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5398913	195208	None	0	Human	Functional	pIC50	=	5.3	5.3	-6	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	432	8	1	2	5.3	CN(C)C(=O)C(CCN[C@@H]1C[C@H]1c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	3038495	708	None	33	Human	Functional	pIC50	=	7.3	7.3	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	7625	708	None	33	Human	Functional	pIC50	=	7.3	7.3	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	CHEMBL25236	708	None	33	Human	Functional	pIC50	=	7.3	7.3	-8	8	Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3Mitogenic stimulation in CHO cells expressing human Dopamine receptor D3	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm040190e
	1577	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	2537	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	5355	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	5501	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	643497	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	688272	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	688272.0	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	958	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	960	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL196677	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL26	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL267044	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	DB00391	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	DB16021	3703	None	66	Human	Functional	pIC50	=	6.3	6.3	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	172313129	196051	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	506	9	0	6	5.3	CCC1(CC)CC(OCCCN2CCN(c3cccc(C(F)(F)F)n3)CC2)(c2ccccn2)CCO1	10.1021/acs.jmedchem.3c00417
	CHEMBL5415842	196051	None	0	Human	Functional	pIC50	=	6.3	6.3	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	506	9	0	6	5.3	CCC1(CC)CC(OCCCN2CCN(c3cccc(C(F)(F)F)n3)CC2)(c2ccccn2)CCO1	10.1021/acs.jmedchem.3c00417
	168475866	196686	None	2	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysisAntagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis	ChEMBL	455	11	2	6	5.1	CCCCCCOc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OCCOCC)c3CN1CC2	10.1021/acs.jmedchem.3c00976
	CHEMBL5429932	196686	None	2	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysisAntagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis	ChEMBL	455	11	2	6	5.1	CCCCCCOc1cc2c(cc1O)[C@@H]1Cc3ccc(O)c(OCCOCC)c3CN1CC2	10.1021/acs.jmedchem.3c00976
	9887463	206845	None	0	Human	Functional	pIC50	=	8.2	8.2	1	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C\CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1016/s0960-894x(03)00389-5
	CHEMBL71865	206845	None	0	Human	Functional	pIC50	=	8.2	8.2	1	2	Agonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cellsAgonistic activity of quinpirole stimulation of mitogenesis in human Dopamine receptor D3 transfected CHO cells	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C\CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1016/s0960-894x(03)00389-5
	9887463	206845	None	0	Human	Functional	pIC50	=	8.2	8.2	1	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C\CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm040190e
	CHEMBL71865	206845	None	0	Human	Functional	pIC50	=	8.2	8.2	1	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C\CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm040190e
	9826580	206431	None	4	Human	Functional	pIC50	=	8.2	8.2	14	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm040190e
	CHEMBL69451	206431	None	4	Human	Functional	pIC50	=	8.2	8.2	14	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	482	8	1	4	5.4	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccn2)cc1	10.1021/jm040190e
	42625211	56255	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	CHEMBL1627309	56255	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
	42626240	56253	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC[C@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627307	56253	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	460	7	3	4	3.8	O=C(NCC[C@H](O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	44427821	153822	None	0	Human	Functional	pIC50	=	8.2	8.2	190	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.5	Cc1cccc(-c2ccc(C(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)n1	10.1021/jm0704200
	CHEMBL398175	153822	None	0	Human	Functional	pIC50	=	8.2	8.2	190	2	Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayAntagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assay	ChEMBL	494	7	1	4	5.5	Cc1cccc(-c2ccc(C(=O)NC/C=C/CN3CCN(c4cccc(Cl)c4Cl)CC3)cc2)n1	10.1021/jm0704200
	168679651	195904	None	2	Human	Functional	pIC50	=	6.2	6.2	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	428	9	1	3	4.6	COc1ccccc1[C@@H]1C[C@H]1NCCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5412995	195904	None	2	Human	Functional	pIC50	=	6.2	6.2	1	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	428	9	1	3	4.6	COc1ccccc1[C@@H]1C[C@H]1NCCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	164622805	185969	None	0	Human	Functional	pIC50	=	7.2	7.2	-5	6	Antagonist activity at D3 receptor (unknown origin)Antagonist activity at D3 receptor (unknown origin)	ChEMBL	467	9	0	6	4.5	Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCOCC5)cc4)CC3)noc2c1	10.1016/j.bmcl.2021.127909
	CHEMBL4867978	185969	None	0	Human	Functional	pIC50	=	7.2	7.2	-5	6	Antagonist activity at D3 receptor (unknown origin)Antagonist activity at D3 receptor (unknown origin)	ChEMBL	467	9	0	6	4.5	Fc1ccc2c(C3CCN(CCCOc4ccc(CCN5CCOCC5)cc4)CC3)noc2c1	10.1016/j.bmcl.2021.127909
	1577	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	2537	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	5355	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	5501	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	643497	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	688272	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	688272.0	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	958	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	960	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL196677	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL26	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	CHEMBL267044	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	DB00391	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	DB16021	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/jm200288r
	164937992	195263	None	0	Human	Functional	pIC50	=	5.2	5.2	-45	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	351	5	0	4	4.8	Cc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5399689	195263	None	0	Human	Functional	pIC50	=	5.2	5.2	-45	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	351	5	0	4	4.8	Cc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	1577	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	2537	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	5355	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	5501	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	643497	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	688272	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	688272.0	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	958	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	960	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	CHEMBL196677	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	CHEMBL26	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	CHEMBL267044	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	DB00391	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	DB16021	3703	None	66	Human	Functional	pIC50	=	7.2	7.2	-3	8	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1021/acs.jmedchem.3c00734
	53248158	62008	None	0	Human	Functional	pIC50	=	6.2	6.2	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	CHEMBL1774383	62008	None	0	Human	Functional	pIC50	=	6.2	6.2	-7	2	Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assayAntagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as inhibition of dopamine-induced recruitment of beta-arrestin-2 after 90 mins by beta-galactosidase assay	ChEMBL	462	9	1	5	4.0	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2ccc(-c3ccccn3)cc2)CC1	10.1021/jm200288r
	42626103	56269	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	CHEMBL1627323	56269	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
	10001256	206749	None	0	Human	Functional	pIC50	=	8.1	8.1	2	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm040190e
	CHEMBL71327	206749	None	0	Human	Functional	pIC50	=	8.1	8.1	2	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	403	6	1	3	4.1	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1	10.1021/jm040190e
	53248210	62051	None	0	Human	Functional	pIC50	=	6.1	6.1	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	CHEMBL1774532	62051	None	0	Human	Functional	pIC50	=	6.1	6.1	-1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	455	9	1	6	3.7	COc1ccc2oc(C(=O)NCCC(F)CN3CCN(c4ccccc4OC)CC3)cc2c1	10.1021/jm200288r
	164916967	195989	None	2	Human	Functional	pIC50	=	7.1	7.1	45	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5414796	195989	None	2	Human	Functional	pIC50	=	7.1	7.1	45	2	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	679	13	2	6	4.9	CN(C)C(=O)C(CCN1C[C@H](O)C[C@H]1C(=O)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	53248257	62056	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	511	7	1	3	5.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm200288r
	CHEMBL1774537	62056	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	511	7	1	3	5.8	O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2	10.1021/jm200288r
	53248212	62053	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	424	8	2	4	3.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm200288r
	CHEMBL1774534	62053	None	0	Human	Functional	pIC50	=	6.1	6.1	1	2	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	424	8	2	4	3.5	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm200288r
	53248258	62057	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	CHEMBL1774538	62057	None	0	Human	Functional	pIC50	=	7.1	7.1	-1	3	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	441	8	1	5	4.2	COc1ccccc1N1CCN(CC(F)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm200288r
	164937998	196922	None	0	Human	Functional	pIC50	=	5.1	5.1	-35	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc(C2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5434856	196922	None	0	Human	Functional	pIC50	=	5.1	5.1	-35	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc(C2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	172439985	195264	None	0	Human	Functional	pIC50	=	5.1	5.1	-35	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	CHEMBL5399720	195264	None	0	Human	Functional	pIC50	=	5.1	5.1	-35	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	367	6	0	5	4.5	COc1ccc2nc(CCCN3CCC(c4ccccn4)CC3)sc2c1	10.1021/acs.jmedchem.3c00734
	9980998	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL139926	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	CHEMBL2112911	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
	9980998	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm040190e
	CHEMBL139926	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm040190e
	CHEMBL2112911	31043	None	0	Human	Functional	pIC50	=	8.0	8.0	12	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm040190e
	11351639	60544	None	0	Human	Functional	pIC50	=	8.0	8.0	26	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	CHEMBL175734	60544	None	0	Human	Functional	pIC50	=	8.0	8.0	26	2	Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesisAntagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
	11351639	60544	None	0	Human	Functional	pIC50	=	8.0	8.0	26	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm040190e
	CHEMBL175734	60544	None	0	Human	Functional	pIC50	=	8.0	8.0	26	2	Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptorMitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D3 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm040190e
	133633	2241	None	40	Human	Functional	pIC50	=	7.0	7.0	-20	4	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	177	2241	None	40	Human	Functional	pIC50	=	7.0	7.0	-20	4	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	CHEMBL445102	2241	None	40	Human	Functional	pIC50	=	7.0	7.0	-20	4	Antagonist activity at dopamine D3 receptorAntagonist activity at dopamine D3 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
	172441436	195050	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	670	13	1	7	5.2	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2nsc3ccccc23)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	CHEMBL5395539	195050	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assayAntagonist activity at SNAP-tagged human D3R receptor transfected in HEK293T cells coexpressing wild type Galpha-oA, venus-tagged Gbeta-1 (156 to 239 residues), venus-tagged Ggamma2 (1 to 155 residues) and Rluc8 fused masGRK3ct assessed as Galpha-oA activation using coelenterazine as substrate incubated for 40 mins in presence of quinpirole by BRET based GPA assay	ChEMBL	670	13	1	7	5.2	CN(C)C(=O)C(CCN1C[C@H](F)C[C@H]1C(=O)NCCCCN1CCN(c2nsc3ccccc23)CC1)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.3c00417
	53248395	61803	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	511	8	0	3	6.5	CN(CCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)Cc1ccc2c(c1)Cc1ccccc1-2	10.1021/jm200288r
	CHEMBL1773087	61803	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis	ChEMBL	511	8	0	3	6.5	CN(CCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)Cc1ccc2c(c1)Cc1ccccc1-2	10.1021/jm200288r
	2470	3653	None	40	Human	Functional	pIC50	=	7.0	7.0	-213	23	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/acs.jmedchem.8b01096
	3300	3653	None	40	Human	Functional	pIC50	=	7.0	7.0	-213	23	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/acs.jmedchem.8b01096
	5265	3653	None	40	Human	Functional	pIC50	=	7.0	7.0	-213	23	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/acs.jmedchem.8b01096
	99	3653	None	40	Human	Functional	pIC50	=	7.0	7.0	-213	23	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/acs.jmedchem.8b01096
	CHEMBL267930	3653	None	40	Human	Functional	pIC50	=	7.0	7.0	-213	23	Antagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assayAntagonist activity at dopamine D3 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of dopamine-induced calcium flux after 15 mins by calcium 4-dye based FLIPR assay	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/acs.jmedchem.8b01096
	164937983	196526	None	0	Human	Functional	pIC50	=	6.0	6.0	-2	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	366	6	0	5	4.1	Cc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5425920	196526	None	0	Human	Functional	pIC50	=	6.0	6.0	-2	3	Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysisAntagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal screen substrate based luminescence analysis	ChEMBL	366	6	0	5	4.1	Cc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	71452041	1944	None	4	Human	Functional	pIC50	=	6.0	6.0	-72	3	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	309	8	1	2	4.3	Oc1cccc(c1)CCN(CC1CCC1)CCc1ccccc1	10.1021/jm301258w
	9189	1944	None	4	Human	Functional	pIC50	=	6.0	6.0	-72	3	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	309	8	1	2	4.3	Oc1cccc(c1)CCN(CC1CCC1)CCc1ccccc1	10.1021/jm301258w
	CHEMBL2180639	1944	None	4	Human	Functional	pIC50	=	6.0	6.0	-72	3	Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assayAntagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay	ChEMBL	309	8	1	2	4.3	Oc1cccc(c1)CCN(CC1CCC1)CCc1ccccc1	10.1021/jm301258w
	11016342	102859	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	481	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccc2)cc1	10.1021/jm050729o
	CHEMBL305362	102859	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	481	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(-c2ccccc2)cc1	10.1021/jm050729o
	6674	2817	None	23	Human	Functional	pKd	=	8.7	8.7	151	2	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm050729o
	9891901	2817	None	23	Human	Functional	pKd	=	8.7	8.7	151	2	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm050729o
	CHEMBL300780	2817	None	23	Human	Functional	pKd	=	8.7	8.7	151	2	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	493	7	1	3	5.9	O=C(c1ccc2c(c1)Cc1c2cccc1)NCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm050729o
	3038495	708	None	33	Human	Functional	pKd	=	7.8	7.8	-8	8	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050729o
	7625	708	None	33	Human	Functional	pKd	=	7.8	7.8	-8	8	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050729o
	CHEMBL25236	708	None	33	Human	Functional	pKd	=	7.8	7.8	-8	8	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050729o
	11533234	123205	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	487	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)[C@H]1CC[C@H](c2ccccc2)CC1	10.1021/jm050729o
	CHEMBL361228	123205	None	0	Human	Functional	pKd	=	7.6	7.6	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	487	8	1	3	6.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)[C@H]1CC[C@H](c2ccccc2)CC1	10.1021/jm050729o
	10939408	47437	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	7	1	3	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1	10.1021/jm050729o
	CHEMBL154508	47437	None	0	Human	Functional	pKd	=	8.5	8.5	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	455	7	1	3	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2ccccc2c1	10.1021/jm050729o
	1353	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	3559	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	3559.0	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	86	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	CHEMBL54	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	DB00502	1911	None	63	Human	Functional	pKd	=	6.5	6.5	2	39	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm050729o
	10939167	9502	None	0	Human	Functional	pKd	=	7.4	7.4	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm050729o
	CHEMBL112065	9502	None	0	Human	Functional	pKd	=	7.4	7.4	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm050729o
	CHEMBL129483	9502	None	0	Human	Functional	pKd	=	7.4	7.4	-	1	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm050729o
	11510684	166278	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	CHEMBL426414	166278	None	0	Human	Functional	pKd	=	8.1	8.1	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	449	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)[C@H]2CC[C@H](c3ccccc3)CC2)CC1	10.1021/jm050729o
	11647384	59123	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccccc23)CC1	10.1021/jm050729o
	CHEMBL169766	59123	None	0	Human	Functional	pKd	=	7.1	7.1	-	0	Intrinsic activity against dopamine receptor D3 by Eu-GTP binding assayIntrinsic activity against dopamine receptor D3 by Eu-GTP binding assay	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccccc23)CC1	10.1021/jm050729o
	121304452	149006	None	0	Human	Functional	pKi	=	10.2	10.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(-c2ncco2)cc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3941818	149006	None	0	Human	Functional	pKi	=	10.2	10.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(-c2ncco2)cc1	10.1021/acs.jmedchem.6b00972
	121304452	149006	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(-c2ncco2)cc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3941818	149006	None	0	Human	Functional	pKi	=	9.7	9.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(-c2ncco2)cc1	10.1021/acs.jmedchem.6b00972
	57533	206397	None	31	Human	Functional	pKi	=	9.7	9.7	-	1	Agonistic activity at DRD3 receptorAgonistic activity at DRD3 receptor	ChEMBL	247	2	1	3	2.5	CCCN1CCO[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.07.055
	CHEMBL1288585	206397	None	31	Human	Functional	pKi	=	9.7	9.7	-	1	Agonistic activity at DRD3 receptorAgonistic activity at DRD3 receptor	ChEMBL	247	2	1	3	2.5	CCCN1CCO[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.07.055
	CHEMBL2106804	206397	None	31	Human	Functional	pKi	=	9.7	9.7	-	1	Agonistic activity at DRD3 receptorAgonistic activity at DRD3 receptor	ChEMBL	247	2	1	3	2.5	CCCN1CCO[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.07.055
	CHEMBL69271	206397	None	31	Human	Functional	pKi	=	9.7	9.7	-	1	Agonistic activity at DRD3 receptorAgonistic activity at DRD3 receptor	ChEMBL	247	2	1	3	2.5	CCCN1CCO[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1016/j.bmcl.2009.07.055
	44627351	6257	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081587	6257	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	11272440	6276	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.1	Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081685	6276	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.1	Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	11397777	6290	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	7	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)s1	10.1021/jm901319p
	CHEMBL1081746	6290	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	7	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)s1	10.1021/jm901319p
	46881466	7265	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	327	3	1	2	3.1	O=C1N(CC2CCCCN2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1085903	7265	None	0	Human	Functional	pKi	=	9.6	9.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	327	3	1	2	3.1	O=C1N(CC2CCCCN2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2010.01.090
	11213136	5947	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079824	5947	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	121304527	147128	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	445	7	0	7	4.4	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3926847	147128	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	445	7	0	7	4.4	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	121304437	151055	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	478	7	0	5	6.2	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCCCC1	10.1021/acs.jmedchem.6b00972
	CHEMBL3958201	151055	None	0	Human	Functional	pKi	=	9.5	9.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	478	7	0	5	6.2	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCCCC1	10.1021/acs.jmedchem.6b00972
	121304569	146298	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(-c2ncco2)c1	10.1021/acs.jmedchem.6b00972
	CHEMBL3920167	146298	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	539	8	0	7	6.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(-c2ncco2)c1	10.1021/acs.jmedchem.6b00972
	121304408	143641	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	515	8	1	6	5.0	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)cc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3899125	143641	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	515	8	1	6	5.0	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)cc1	10.1021/acs.jmedchem.6b00972
	44627123	6047	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1080490	6047	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	44627025	6362	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1082106	6362	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	23630606	92260	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1	10.1021/jm0705612
	CHEMBL242600	92260	None	0	Human	Functional	pKi	=	9.4	9.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1	10.1021/jm0705612
	44626929	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1079481	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	44627133	6331	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1081957	6331	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	44626929	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.07.073
	CHEMBL1079481	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.07.073
	44626929	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079481	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	11305766	5915	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	462	7	0	6	5.2	Cc1ccoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079639	5915	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	462	7	0	6	5.2	Cc1ccoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	44627357	5993	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080126	5993	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	44627133	6331	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081957	6331	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	44626929	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm100832d
	CHEMBL1079481	5886	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm100832d
	121304538	150093	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	516	8	1	7	4.4	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)nc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3950254	150093	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	516	8	1	7	4.4	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccc(C(N)=O)nc1	10.1021/acs.jmedchem.6b00972
	121304551	151721	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	427	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3963783	151721	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	427	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	121315401	153197	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	478	7	0	6	5.9	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccs1	10.1021/acs.jmedchem.6b00972
	CHEMBL3976319	153197	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	478	7	0	6	5.9	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccs1	10.1021/acs.jmedchem.6b00972
	121304441	152473	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	515	8	1	6	5.0	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b00972
	CHEMBL3970323	152473	None	0	Human	Functional	pKi	=	9.3	9.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	515	8	1	6	5.0	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cccc(C(N)=O)c1	10.1021/acs.jmedchem.6b00972
	121304649	150733	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	495	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3955505	150733	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	495	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	11996304	15213	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210614	15213	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	45267491	198448	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	3	4.1	O=C1N(CCN2CCCc3sccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL559873	198448	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	3	4.1	O=C1N(CCN2CCCc3sccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	11260032	5885	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	474	7	0	7	4.4	Cc1cnc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1	10.1021/jm901319p
	CHEMBL1079480	5885	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	474	7	0	7	4.4	Cc1cnc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1	10.1021/jm901319p
	44627357	5993	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080126	5993	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	44626744	6277	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	458	7	0	5	5.3	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccc1	10.1021/jm901319p
	CHEMBL1081686	6277	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	458	7	0	5	5.3	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccc1	10.1021/jm901319p
	44627359	6317	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081868	6317	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1204409	6317	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	46931815	17310	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	479	7	0	7	6.0	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(C)(C)C)cc2)C3)n1C	10.1021/jm100832d
	CHEMBL1257215	17310	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	479	7	0	7	6.0	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(C)(C)C)cc2)C3)n1C	10.1021/jm100832d
	9828617	92996	None	5	Human	Functional	pKi	=	9.2	9.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	536	7	1	7	4.2	Cc1nc(-c2cccc(C(=O)N[C@H]3CC[C@H](CCN4CCc5ccc(S(C)(=O)=O)cc5CC4)CC3)c2)no1	10.1021/jm0705612
	CHEMBL244083	92996	None	5	Human	Functional	pKi	=	9.2	9.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	536	7	1	7	4.2	Cc1nc(-c2cccc(C(=O)N[C@H]3CC[C@H](CCN4CCc5ccc(S(C)(=O)=O)cc5CC4)CC3)c2)no1	10.1021/jm0705612
	CHEMBL3084616	92996	None	5	Human	Functional	pKi	=	9.2	9.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	536	7	1	7	4.2	Cc1nc(-c2cccc(C(=O)N[C@H]3CC[C@H](CCN4CCc5ccc(S(C)(=O)=O)cc5CC4)CC3)c2)no1	10.1021/jm0705612
	23631454	93161	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)cc4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244279	93161	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)cc4)n2C)CC3)no1	10.1021/jm0705612
	121304654	148965	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	530	8	1	7	4.7	Cc1nc(C(N)=O)ccc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3941520	148965	None	0	Human	Functional	pKi	=	9.2	9.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	530	8	1	7	4.7	Cc1nc(C(N)=O)ccc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	121304485	148263	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	477	7	0	7	5.2	Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3935692	148263	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	477	7	0	7	5.2	Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	11996303	15207	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210552	15207	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	11699532	155249	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	542	7	0	9	5.2	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL402215	155249	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	542	7	0	9	5.2	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	11504077	168932	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL437792	168932	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(C)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	44627127	5881	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1079461	5881	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	11477018	5916	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	6	5.0	Cc1ccc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1	10.1021/jm901319p
	CHEMBL1079640	5916	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	6	5.0	Cc1ccc(-c2nnc(SCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)n2C)cn1	10.1021/jm901319p
	44627023	5945	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079822	5945	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	44627355	5968	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	CHEMBL1079938	5968	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	44626928	6017	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1080293	6017	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(F)(F)F)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627359	6317	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081868	6317	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1204409	6317	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	11720838	167281	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	6	0	8	6.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL429132	167281	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	6	0	8	6.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	121315244	149673	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	473	7	0	6	5.3	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccn1	10.1021/acs.jmedchem.6b00972
	CHEMBL3946901	149673	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	473	7	0	6	5.3	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccccn1	10.1021/acs.jmedchem.6b00972
	44249745	197899	None	1	Rat	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity at rat DRD3 receptorAntagonistic activity at rat DRD3 receptor	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.07.055
	CHEMBL552373	197899	None	1	Rat	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity at rat DRD3 receptorAntagonistic activity at rat DRD3 receptor	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.07.055
	CHEMBL567286	197899	None	1	Rat	Functional	pKi	=	9.1	9.1	-	0	Antagonistic activity at rat DRD3 receptorAntagonistic activity at rat DRD3 receptor	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.07.055
	23631173	92259	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1cccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)c1	10.1021/jm0705612
	CHEMBL242599	92259	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1cccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)c1	10.1021/jm0705612
	23631091	150972	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	462	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL395743	150972	None	0	Human	Functional	pKi	=	9.1	9.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	462	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)no1	10.1021/jm0705612
	11996303	15207	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210552	15207	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	11621352	97686	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL271034	97686	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	44626740	5992	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1080117	5992	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627120	6046	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	CHEMBL1080489	6046	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	44627242	6120	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080846	6120	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	11225043	6226	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081409	6226	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	11751828	6278	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	6	5.0	Cc1ncccc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081687	6278	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	6	5.0	Cc1ncccc1-c1nnc(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	11397017	6316	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	460	7	0	7	4.0	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccnnc1	10.1021/jm901319p
	CHEMBL1081867	6316	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	460	7	0	7	4.0	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccnnc1	10.1021/jm901319p
	44626530	6329	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081934	6329	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	44627240	6332	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081966	6332	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	11606176	95187	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	527	7	0	9	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(N(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255620	95187	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	527	7	0	9	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(N(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882051	6240	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	355	4	0	2	3.8	O=C1N(CCN2CCCCCC2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081488	6240	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	355	4	0	2	3.8	O=C1N(CCN2CCCCCC2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2010.01.090
	44249745	197899	None	1	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL552373	197899	None	1	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL567286	197899	None	1	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	45269020	198524	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	467	4	0	2	3.8	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(I)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL560574	198524	None	0	Human	Functional	pKi	=	9	9.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	467	4	0	2	3.8	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(I)c1	10.1016/j.bmcl.2009.06.028
	23630903	150968	None	0	Human	Functional	pKi	=	9	9.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2cc(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)ccc2n1	10.1021/jm0705612
	CHEMBL395741	150968	None	0	Human	Functional	pKi	=	9	9.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2cc(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)ccc2n1	10.1021/jm0705612
	23630501	152718	None	0	Human	Functional	pKi	=	9	9.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	527	7	0	7	6.3	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)c(Cl)c4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL397222	152718	None	0	Human	Functional	pKi	=	9	9.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	527	7	0	7	6.3	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(Cl)c(Cl)c4)n2C)CC3)no1	10.1021/jm0705612
	11584660	93321	None	8	Human	Functional	pKi	=	9	9.0	-	5	Displacement of [35S]GTP-gamma-S from human recombinant dopamine D3 receptor expressed in CHO cells after 30 mins at 10 uMDisplacement of [35S]GTP-gamma-S from human recombinant dopamine D3 receptor expressed in CHO cells after 30 mins at 10 uM	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93321	None	8	Human	Functional	pKi	=	9	9.0	-	5	Displacement of [35S]GTP-gamma-S from human recombinant dopamine D3 receptor expressed in CHO cells after 30 mins at 10 uMDisplacement of [35S]GTP-gamma-S from human recombinant dopamine D3 receptor expressed in CHO cells after 30 mins at 10 uM	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	121304711	150025	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	491	7	0	6	5.4	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)nnc1-c1cccnc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3949662	150025	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	491	7	0	6	5.4	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)nnc1-c1cccnc1	10.1021/acs.jmedchem.6b00972
	11996304	15213	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210614	15213	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	16123247	16295	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	386	6	2	4	3.5	COc1cc([C@]23CNC[C@H]2C3)ccc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224699	16295	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	386	6	2	4	3.5	COc1cc([C@]23CNC[C@H]2C3)ccc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/j.bmcl.2010.07.073
	45273522	198978	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	333	4	0	2	3.6	O=C1N(CCN2[C@H]3CCC[C@@H]2CC3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL563580	198978	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	333	4	0	2	3.6	O=C1N(CCN2[C@H]3CCC[C@@H]2CC3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	44626738	5904	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079578	5904	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	44627355	5968	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	CHEMBL1079938	5968	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	44626835	6001	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	533	7	0	6	5.9	Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(Br)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1080165	6001	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	533	7	0	6	5.9	Cc1ccc2c(-c3nnc(SCCCN4C[C@@H]5C[C@]5(c5ccc(Br)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627123	6047	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1080490	6047	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	24743758	6152	None	20	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081023	6152	None	20	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	44627470	6225	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	8	0	8	4.6	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1C(F)(F)F	10.1021/jm901319p
	CHEMBL1081408	6225	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	8	0	8	4.6	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1C(F)(F)F	10.1021/jm901319p
	44627351	6257	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081587	6257	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	45268112	198666	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.3	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL561512	198666	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.3	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2009.06.028
	45271511	199924	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	357	4	1	3	2.9	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL569846	199924	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	357	4	1	3	2.9	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(O)c1	10.1016/j.bmcl.2009.06.028
	23631172	92258	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	467	7	0	8	4.3	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCOCC4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL242598	92258	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	467	7	0	8	4.3	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCOCC4)n2C)CC3)no1	10.1021/jm0705612
	23630602	92901	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	479	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCC(C)CC4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243860	92901	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	479	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCC(C)CC4)n2C)CC3)no1	10.1021/jm0705612
	23630497	92999	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	465	7	0	8	5.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244086	92999	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	465	7	0	8	5.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)no1	10.1021/jm0705612
	135846033	152952	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	498	7	1	7	5.5	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cc5ccccc5[nH]4)n2C)CC3)o1	10.1021/jm0705612
	CHEMBL397429	152952	None	0	Human	Functional	pKi	=	8.9	8.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	498	7	1	7	5.5	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cc5ccccc5[nH]4)n2C)CC3)o1	10.1021/jm0705612
	9904074	110691	None	3	Human	Functional	pKi	=	8.9	8.9	-	1	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	289	5	1	4	3.5	CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1	10.1016/j.ejmech.2022.114378
	CHEMBL325710	110691	None	3	Human	Functional	pKi	=	8.9	8.9	-	1	Agonist activity at dopamine D3 receptor (unknown origin)Agonist activity at dopamine D3 receptor (unknown origin)	ChEMBL	289	5	1	4	3.5	CCCN(CCC)C1Cc2cc3nc(N)sc3cc2C1	10.1016/j.ejmech.2022.114378
	121304464	144432	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	480	7	0	8	4.7	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1csnn1	10.1021/acs.jmedchem.6b00972
	CHEMBL3905582	144432	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	480	7	0	8	4.7	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1csnn1	10.1021/acs.jmedchem.6b00972
	121304597	146512	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	441	7	0	6	4.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(F)cc3F)C2)nnc1-c1cccnc1	10.1021/acs.jmedchem.6b00972
	CHEMBL3921885	146512	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	441	7	0	6	4.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(F)cc3F)C2)nnc1-c1cccnc1	10.1021/acs.jmedchem.6b00972
	121304500	149842	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	480	7	0	6	5.1	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCOCC1	10.1021/acs.jmedchem.6b00972
	CHEMBL3948167	149842	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	480	7	0	6	5.1	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCOCC1	10.1021/acs.jmedchem.6b00972
	11584660	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL244946	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11691697	97769	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	492	6	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL271449	97769	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	492	6	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	11584660	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	CHEMBL244946	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	45272635	198263	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	423	6	0	2	5.1	CN(CCN1CCN(c2cccc(C(F)(F)F)c2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	CHEMBL558058	198263	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	423	6	0	2	5.1	CN(CCN1CCN(c2cccc(C(F)(F)F)c2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	11775544	5883	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	460	7	0	7	4.0	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cncnc1	10.1021/jm901319p
	CHEMBL1079475	5883	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	460	7	0	7	4.0	Cn1c(SCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)nnc1-c1cncnc1	10.1021/jm901319p
	24743758	6152	None	20	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081023	6152	None	20	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	44626637	6224	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081401	6224	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44626530	6329	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081934	6329	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	44627353	6364	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1082111	6364	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	11584660	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL244946	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm901319p
	44454190	98118	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1	10.1016/j.bmcl.2007.12.066
	CHEMBL273199	98118	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	537	7	0	8	5.6	Cc1cc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2cn1	10.1016/j.bmcl.2007.12.066
	46882007	6215	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	355	4	0	2	4.1	O=C1N(CCN2CCCCCC2)CCN1c1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081309	6215	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	355	4	0	2	4.1	O=C1N(CCN2CCCCCC2)CCN1c1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2010.01.090
	45273266	198084	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(F)cc(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL556272	198084	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(F)cc(Cl)c1	10.1016/j.bmcl.2009.06.028
	45273292	198833	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	3.9	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL562624	198833	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	3.9	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	45268113	199183	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	391	5	0	3	3.8	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(OC(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL565017	199183	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	391	5	0	3	3.8	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(OC(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	11663999	92263	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	551	7	0	8	6.0	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL242603	92263	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	551	7	0	8	6.0	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	23630999	92871	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	459	7	0	7	5.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccc4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243709	92871	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	459	7	0	7	5.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccc4)n2C)CC3)no1	10.1021/jm0705612
	23630900	93158	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	498	7	1	7	5.5	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5[nH]ccc5c4)n2C)CC3)o1	10.1021/jm0705612
	CHEMBL244276	93158	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	498	7	1	7	5.5	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5[nH]ccc5c4)n2C)CC3)o1	10.1021/jm0705612
	23630901	93159	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	462	7	0	8	4.4	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)o1	10.1021/jm0705612
	CHEMBL244277	93159	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	462	7	0	8	4.4	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccn4C)n2C)CC3)o1	10.1021/jm0705612
	23631092	93160	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(Cl)c4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244278	93160	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(Cl)c4)n2C)CC3)no1	10.1021/jm0705612
	44428207	93162	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	477	7	0	7	5.2	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(F)c4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244280	93162	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	477	7	0	7	5.2	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccc(F)c4)n2C)CC3)no1	10.1021/jm0705612
	11584660	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	93321	None	8	Human	Functional	pKi	=	8.8	8.8	-	5	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	11555265	93347	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	508	7	0	7	5.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1	10.1021/jm0705612
	CHEMBL245118	93347	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	508	7	0	7	5.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1	10.1021/jm0705612
	23631366	150970	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	473	7	0	7	5.3	Cc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1	10.1021/jm0705612
	CHEMBL395742	150970	None	0	Human	Functional	pKi	=	8.8	8.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	473	7	0	7	5.3	Cc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cc1	10.1021/jm0705612
	11548239	95352	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	528	7	0	8	6.1	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL256442	95352	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	528	7	0	8	6.1	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	11606378	95368	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL256488	95368	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(C)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	44627033	5950	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079837	5950	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	44626637	6224	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081401	6224	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627240	6332	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081966	6332	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	44627025	6362	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1082106	6362	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	11705929	92262	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	494	6	0	7	4.7	Cc1cc(-c2ccc3c(c2)CCN(CCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1	10.1021/jm0705612
	CHEMBL242602	92262	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	494	6	0	7	4.7	Cc1cc(-c2ccc3c(c2)CCN(CCSc2nnc(-c4ccc(F)c(F)c4)n2C)CC3)n(C)n1	10.1021/jm0705612
	23630902	92869	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL243707	92869	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)on6)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	23631540	92900	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	451	7	0	7	5.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCCC4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243859	92900	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	451	7	0	7	5.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C4CCCC4)n2C)CC3)no1	10.1021/jm0705612
	23630796	92997	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6ncc(C)o6)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244084	92997	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6ncc(C)o6)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	45273551	198886	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	355	6	0	2	4.1	CN(CCN1CCN(c2ccccc2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	CHEMBL562948	198886	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	355	6	0	2	4.1	CN(CCN1CCN(c2ccccc2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	44627466	6318	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	427	7	0	7	4.0	Cc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c(F)c1	10.1021/jm901319p
	CHEMBL1081869	6318	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	427	7	0	7	4.0	Cc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c(F)c1	10.1021/jm901319p
	49781476	17342	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.7	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(F)(F)F)cc2)C3)n1C	10.1021/jm100832d
	CHEMBL1257336	17342	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.7	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(F)(F)F)cc2)C3)n1C	10.1021/jm100832d
	52940788	17528	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	505	7	0	7	5.6	Cc1nc(C)c(-c2nnc(SCCCN3CCC4CC4(c4ccc(C(F)(F)F)cc4)CC3)n2C)o1	10.1021/jm100832d
	CHEMBL1257925	17528	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	505	7	0	7	5.6	Cc1nc(C)c(-c2nnc(SCCCN3CCC4CC4(c4ccc(C(F)(F)F)cc4)CC3)n2C)o1	10.1021/jm100832d
	11590828	95270	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	466	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(C)C)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL256016	95270	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	466	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(C)C)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	121304685	145473	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	493	7	1	6	4.2	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCNC(=O)C1	10.1021/acs.jmedchem.6b00972
	CHEMBL3913849	145473	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	493	7	1	6	4.2	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCNC(=O)C1	10.1021/acs.jmedchem.6b00972
	121304754	154052	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	507	7	0	6	4.5	CN1CCC(c2nnc(SCCCN3CC[C@]4(C[C@@H]4c4ccc(C(F)(F)F)cc4)C3)n2C)CC1=O	10.1021/acs.jmedchem.6b00972
	CHEMBL3983684	154052	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	507	7	0	6	4.5	CN1CCC(c2nnc(SCCCN3CC[C@]4(C[C@@H]4c4ccc(C(F)(F)F)cc4)C3)n2C)CC1=O	10.1021/acs.jmedchem.6b00972
	45268142	198451	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	371	5	0	3	3.2	COc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559920	198451	None	0	Human	Functional	pKi	=	8	8.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	371	5	0	3	3.2	COc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	23631458	92910	None	0	Human	Functional	pKi	=	8	8.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	451	6	0	7	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(F)(F)F)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243900	92910	None	0	Human	Functional	pKi	=	8	8.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	451	6	0	7	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(F)(F)F)n2C)CC3)no1	10.1021/jm0705612
	23630505	92911	None	0	Human	Functional	pKi	=	8	8.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	425	7	0	7	4.5	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(C)C)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243901	92911	None	0	Human	Functional	pKi	=	8	8.0	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	425	7	0	7	4.5	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(C)C)n2C)CC3)no1	10.1021/jm0705612
	46882520	5858	None	0	Human	Functional	pKi	=	7	7.0	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5858	None	0	Human	Functional	pKi	=	7	7.0	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	44454358	155280	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL402422	155280	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	45273529	198179	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	413	7	0	3	4.3	O=C1N(CCN2CCCC(OCc3ccccc3)C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL557110	198179	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	413	7	0	3	4.3	O=C1N(CCN2CCCC(OCc3ccccc3)C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	24815439	204392	None	1	Human	Functional	pKi	=	7	7.0	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	323	3	0	3	4.1	Cn1c(CN2CCC(c3ccccc3F)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL607689	204392	None	1	Human	Functional	pKi	=	7	7.0	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	323	3	0	3	4.1	Cn1c(CN2CCC(c3ccccc3F)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	44627245	5944	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	477	7	0	7	4.9	Cc1cc(C(F)(F)F)ccc1C12CC1CN(CCCSc1nnc(-c3ocnc3C)n1C)C2	10.1021/jm901319p
	CHEMBL1079814	5944	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	477	7	0	7	4.9	Cc1cc(C(F)(F)F)ccc1C12CC1CN(CCCSc1nnc(-c3ocnc3C)n1C)C2	10.1021/jm901319p
	44627033	5950	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079837	5950	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	24758834	17695	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1ccc2c(c1)CCCC21CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	CHEMBL1258492	17695	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1ccc2c(c1)CCCC21CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	24758838	17732	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	425	6	0	8	3.7	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCOc4ccccc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258606	17732	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	425	6	0	8	3.7	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCOc4ccccc43)C2)n1C	10.1021/jm100832d
	11578028	95149	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	604	7	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(C(C)CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL255417	95149	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	604	7	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(C(C)CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11534726	95185	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	644	6	0	8	7.2	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255618	95185	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	644	6	0	8	7.2	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11662194	97530	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	441	6	0	8	3.7	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(C2CCOCC2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL270209	97530	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	441	6	0	8	3.7	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(C2CCOCC2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11712044	97929	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	448	7	0	8	4.2	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccnc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272302	97929	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	448	7	0	8	4.2	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccnc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	45268120	199091	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	2	4.2	CC(C)(C)c1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)cc1	10.1016/j.bmcl.2009.06.028
	CHEMBL564298	199091	None	0	Human	Functional	pKi	=	7	7.0	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	2	4.2	CC(C)(C)c1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)cc1	10.1016/j.bmcl.2009.06.028
	11996303	15207	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210552	15207	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(S(F)(F)(F)(F)F)cc3)C2)n1C	10.1016/j.bmcl.2010.06.018
	11705119	166579	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	452	7	0	9	4.1	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL427836	166579	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	452	7	0	9	4.1	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	45271737	198974	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	2	4.5	CC1(C)C[C@@H]2C[C@@](C)(CN2CCN2CCN(c3cccc(Cl)c3)C2=O)C1	10.1016/j.bmcl.2009.06.043
	CHEMBL563563	198974	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	2	4.5	CC1(C)C[C@@H]2C[C@@](C)(CN2CCN2CCN(c3cccc(Cl)c3)C2=O)C1	10.1016/j.bmcl.2009.06.043
	44627127	5881	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1079461	5881	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	44627022	5922	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	395	7	0	7	3.5	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccccc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079667	5922	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	395	7	0	7	3.5	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccccc3)C2)n1C	10.1021/jm901319p
	44626734	6194	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081237	6194	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	52947516	17458	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm100832d
	CHEMBL1257687	17458	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm100832d
	44454458	95178	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	618	6	0	8	7.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255566	95178	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	618	6	0	8	7.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11519858	97946	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	578	7	0	9	4.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(S(C)(=O)=O)CCO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272379	97946	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	578	7	0	9	4.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(S(C)(=O)=O)CCO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11519134	97984	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272545	97984	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11685267	98112	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	538	8	0	8	6.0	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(CC7CC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL273166	98112	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	538	8	0	8	6.0	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(CC7CC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11518972	155122	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	501	6	0	7	5.5	Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL401576	155122	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	501	6	0	7	5.5	Cc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	45271491	197636	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.3	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL550502	197636	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.3	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	45272414	197895	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.0	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL552366	197895	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.0	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	11598123	93348	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	477	7	0	9	4.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ocnc4C)n2C)CC3)n(C)n1	10.1021/jm0705612
	CHEMBL245119	93348	None	0	Human	Functional	pKi	=	7.9	7.9	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	477	7	0	9	4.1	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ocnc4C)n2C)CC3)n(C)n1	10.1021/jm0705612
	45270916	197289	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	348	6	0	4	3.0	Cc1cc(CN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)on1	10.1016/j.bmcl.2009.06.043
	CHEMBL549438	197289	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	348	6	0	4	3.0	Cc1cc(CN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)on1	10.1016/j.bmcl.2009.06.043
	45271753	198010	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	417	9	0	4	3.8	COc1ccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)cc1OC	10.1016/j.bmcl.2009.06.043
	CHEMBL554693	198010	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	417	9	0	4	3.8	COc1ccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)cc1OC	10.1016/j.bmcl.2009.06.043
	45273530	199034	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	387	8	0	3	3.8	COc1cccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL563926	199034	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	387	8	0	3	3.8	COc1cccc(CCN(C)CCN2CCN(c3cccc(Cl)c3)C2=O)c1	10.1016/j.bmcl.2009.06.043
	24815434	202152	None	0	Human	Functional	pKi	=	6.9	6.9	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	305	3	0	3	4.0	Cn1c(CN2CCC(c3ccccc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL593196	202152	None	0	Human	Functional	pKi	=	6.9	6.9	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	305	3	0	3	4.0	Cn1c(CN2CCC(c3ccccc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	24743758	6152	None	20	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081023	6152	None	20	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm901319p
	44627353	6364	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1082111	6364	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	52948653	17377	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	7	0	7	3.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccccc3)C2)n1C	10.1021/jm100832d
	CHEMBL1257447	17377	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	7	0	7	3.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccccc3)C2)n1C	10.1021/jm100832d
	49780809	17558	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	CHEMBL1258035	17558	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	44454371	95401	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	434	6	0	8	3.9	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccnc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256653	95401	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	434	6	0	8	3.9	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccnc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454166	95590	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	7	0	8	6.3	CCc1nc2cc3c(c(C)c2o1)CCN(C(C)CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL257524	95590	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	7	0	8	6.3	CCc1nc2cc3c(c(C)c2o1)CCN(C(C)CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454217	95679	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	552	5	0	8	6.0	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257900	95679	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	552	5	0	8	6.0	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454339	97889	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	7	0	7	5.7	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272086	97889	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	7	0	7	5.7	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882049	5608	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	301	4	0	2	3.1	Cc1ccc(N2CCN(CCN3CCCCCC3)C2=O)cc1	10.1016/j.bmcl.2010.01.090
	CHEMBL1077348	5608	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	301	4	0	2	3.1	Cc1ccc(N2CCN(CCN3CCCCCC3)C2=O)cc1	10.1016/j.bmcl.2010.01.090
	46881413	7383	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	333	5	0	4	3.6	O=c1n(CCCN2CCCCCC2)ccn1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1086395	7383	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	333	5	0	4	3.6	O=c1n(CCCN2CCCCCC2)ccn1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	45269000	198349	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	347	4	0	3	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc2occc2c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559004	198349	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	347	4	0	3	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc2occc2c1	10.1016/j.bmcl.2009.06.028
	45273273	198925	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	3	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1c1csc2ccccc12	10.1016/j.bmcl.2009.06.028
	CHEMBL563247	198925	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	3	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1c1csc2ccccc12	10.1016/j.bmcl.2009.06.028
	45273293	199063	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	5	0	4	2.0	CC(C)N1CCN(CCN2CCN(c3ccc(F)c(C#N)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL564108	199063	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	5	0	4	2.0	CC(C)N1CCN(CCN2CCN(c3ccc(F)c(C#N)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	45271499	200150	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL571229	200150	None	0	Human	Functional	pKi	=	6.9	6.9	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	11996304	15213	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	CHEMBL1210614	15213	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assayAntagonist activity at dopamine D3 receptor assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by FLIPR assay	ChEMBL	521	8	0	7	6.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(S(F)(F)(F)(F)F)c3)C2)n1C	10.1016/j.bmcl.2010.06.018
	11533448	95105	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	502	6	0	8	4.9	Cc1ncccc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL255158	95105	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	502	6	0	8	4.9	Cc1ncccc1-c1nnc(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	45272616	199171	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	2	4.3	CC1(C)[C@H]2CC[C@]1(C)CN(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	CHEMBL564930	199171	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	375	4	0	2	4.3	CC1(C)[C@H]2CC[C@]1(C)CN(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	44627133	6331	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081957	6331	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	24758830	17658	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	501	6	0	7	5.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCCc4ccc(Br)cc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258381	17658	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	501	6	0	7	5.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCCc4ccc(Br)cc43)C2)n1C	10.1021/jm100832d
	46882053	6242	None	0	Human	Functional	pKi	=	7.8	7.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	305	4	0	2	2.9	O=C1N(CCN2CCCCCC2)CCN1c1cccc(F)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081490	6242	None	0	Human	Functional	pKi	=	7.8	7.8	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	305	4	0	2	2.9	O=C1N(CCN2CCCCCC2)CCN1c1cccc(F)c1	10.1016/j.bmcl.2010.01.090
	45268987	198761	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	350	4	0	3	3.0	N#Cc1cc(N2CCN(CCN3Cc4ccccc4C3)C2=O)ccc1F	10.1016/j.bmcl.2009.06.028
	CHEMBL562176	198761	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	350	4	0	3	3.0	N#Cc1cc(N2CCN(CCN3Cc4ccccc4C3)C2=O)ccc1F	10.1016/j.bmcl.2009.06.028
	11678080	93349	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	523	6	0	8	5.2	Cc1ccc2c(-c3nnc(SCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL245120	93349	None	0	Human	Functional	pKi	=	7.8	7.8	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	523	6	0	8	5.2	Cc1ccc2c(-c3nnc(SCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44454384	95636	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	497	6	0	8	4.9	Cc1ccn2c3c(nc2c1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL257717	95636	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	497	6	0	8	4.9	Cc1ccn2c3c(nc2c1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	44454320	97822	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(C(F)(F)F)cn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL271729	97822	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6ccc(C(F)(F)F)cn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	45268333	195965	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	377	6	0	3	3.2	COCC1[C@@H]2CC[C@H]1CN(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	CHEMBL541435	195965	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	377	6	0	3	3.2	COCC1[C@@H]2CC[C@H]1CN(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	45268346	198628	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	451	6	0	5	4.5	O=C1N(CCN2CCC(c3nnc(-c4ccccc4)o3)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL561326	198628	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	451	6	0	5	4.5	O=C1N(CCN2CCC(c3nnc(-c4ccccc4)o3)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	44626734	6194	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081237	6194	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	52947507	17417	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	7	0	7	3.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4ccccc4)CC3C2)n1C	10.1021/jm100832d
	CHEMBL1257565	17417	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	7	0	7	3.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4ccccc4)CC3C2)n1C	10.1021/jm100832d
	52946432	17836	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	427	6	0	7	4.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4cc(F)ccc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258949	17836	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	427	6	0	7	4.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4cc(F)ccc43)C2)n1C	10.1021/jm100832d
	44454120	95225	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL255827	95225	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454168	95364	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4onc(C)c4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL256475	95364	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	6	0	9	3.8	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4onc(C)c4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	44454223	98027	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	542	6	0	8	4.7	CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272702	98027	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	542	6	0	8	4.7	CC(=O)N1CCOc2cc3c(cc21)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	45272437	197618	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	346	6	0	4	2.0	COc1cccc(N2CCN(CCN3CCN(C(C)C)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL550358	197618	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	346	6	0	4	2.0	COc1cccc(N2CCN(CCN3CCN(C(C)C)CC3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	45272415	197896	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2009.06.028
	CHEMBL552367	197896	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2009.06.028
	45267262	197947	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccc(Cl)cc1	10.1016/j.bmcl.2009.06.028
	CHEMBL553238	197947	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccc(Cl)cc1	10.1016/j.bmcl.2009.06.028
	45272435	200119	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	368	5	0	3	2.7	CC(C)N1CCN(CCN2CCN(c3cccc(Cl)c3F)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL570998	200119	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	368	5	0	3	2.7	CC(C)N1CCN(CCN2CCN(c3cccc(Cl)c3F)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	45272438	200149	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	322	4	0	3	1.8	CN1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL571221	200149	None	0	Human	Functional	pKi	=	6.8	6.8	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	322	4	0	3	1.8	CN1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	46225584	202131	None	0	Human	Functional	pKi	=	5.8	5.8	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	408	3	0	4	5.0	Cn1c(CN2CCC(c3ncc(C(F)(F)F)cc3Cl)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL593056	202131	None	0	Human	Functional	pKi	=	5.8	5.8	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	408	3	0	4	5.0	Cn1c(CN2CCC(c3ncc(C(F)(F)F)cc3Cl)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	46225581	204444	None	0	Human	Functional	pKi	=	5.8	5.8	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	339	3	0	3	4.6	Cn1c(CN2CCC(c3cccc(Cl)c3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL608103	204444	None	0	Human	Functional	pKi	=	5.8	5.8	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	339	3	0	3	4.6	Cn1c(CN2CCC(c3cccc(Cl)c3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	154706123	176393	None	1	Human	Functional	pKi	=	7.8	7.8	-	1	Antagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assayAntagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4593394	176393	None	1	Human	Functional	pKi	=	7.8	7.8	-	1	Antagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assayAntagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595145	176393	None	1	Human	Functional	pKi	=	7.8	7.8	-	1	Antagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assayAntagonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as suppression of dopamine-induced inhibition of isoproterenol-stimulated cAMP accumulation preincubated for 10 mins followed by dopamine stimulation and measured after 20 mins by Glosensor-based luminescence assay	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	46882522	5714	None	0	Human	Functional	pKi	=	7.7	7.7	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5714	None	0	Human	Functional	pKi	=	7.7	7.7	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	11540474	95402	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	492	6	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4nc(C(F)(F)F)oc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL256659	95402	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	492	6	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4nc(C(F)(F)F)oc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	45271738	197831	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	0	2	5.2	C[C@@]12CC(c3ccccc3)C[C@@H](C1)N(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	CHEMBL551927	197831	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	0	2	5.2	C[C@@]12CC(c3ccccc3)C[C@@H](C1)N(CCN1CCN(c3cccc(Cl)c3)C1=O)C2	10.1016/j.bmcl.2009.06.043
	45267504	198488	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	369	6	0	2	4.4	Cc1cccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL560270	198488	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	369	6	0	2	4.4	Cc1cccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)c1	10.1016/j.bmcl.2009.06.043
	44626637	6224	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081401	6224	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	511	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C(C)(C)C)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	11562200	95363	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(C)(F)F)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL256474	95363	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(C)(F)F)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	11657494	95562	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	644	7	0	8	7.2	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257369	95562	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	644	7	0	8	7.2	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11648990	95699	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257946	95699	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6onc(C)c6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11663526	97805	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271632	97805	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)sc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	45267251	198889	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc(F)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL562983	198889	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc(F)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	45102707	5759	None	0	Human	Functional	pKi	=	6.7	6.7	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	465	6	2	6	3.9	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078492	5759	None	0	Human	Functional	pKi	=	6.7	6.7	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	465	6	2	6	3.9	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2009.09.027
	49865623	16038	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc(C34CNCC3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223657	16038	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc(C34CNCC3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	44454352	97998	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	491	6	0	9	4.0	Cc1ncoc1-c1nnc(SCCCN2CCc3nc4cc(C(F)(F)F)ccn4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL272588	97998	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	491	6	0	9	4.0	Cc1ncoc1-c1nnc(SCCCN2CCc3nc4cc(C(F)(F)F)ccn4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	44626527	5889	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	CHEMBL1079494	5889	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	44627357	5993	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080126	5993	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(C(F)(F)F)c(F)c3)C2)n1C	10.1021/jm901319p
	44627470	6225	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	8	0	8	4.6	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1C(F)(F)F	10.1021/jm901319p
	CHEMBL1081408	6225	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	493	8	0	8	4.6	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1C(F)(F)F	10.1021/jm901319p
	44454118	95188	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	424	6	0	9	3.5	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4ncoc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL255621	95188	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	424	6	0	9	3.5	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4ncoc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	44454403	97738	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	464	7	0	9	4.4	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C5CC5)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL271280	97738	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	464	7	0	9	4.4	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C5CC5)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	44454248	97945	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	576	6	0	8	6.0	CCc1nc2cc3c(c(Br)c2o1)CCN(CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272378	97945	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	576	6	0	8	6.0	CCc1nc2cc3c(c(Br)c2o1)CCN(CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	45270678	197913	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	327	4	0	3	3.3	Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)s1	10.1016/j.bmcl.2009.06.028
	CHEMBL552460	197913	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	327	4	0	3	3.3	Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)s1	10.1016/j.bmcl.2009.06.028
	45273278	198154	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	390	5	0	4	4.1	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cscc1-c1ccccn1	10.1016/j.bmcl.2009.06.028
	CHEMBL556895	198154	None	0	Human	Functional	pKi	=	6.7	6.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	390	5	0	4	4.1	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cscc1-c1ccccn1	10.1016/j.bmcl.2009.06.028
	121304417	144219	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	506	7	0	6	5.6	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CC2CCC(C1)O2	10.1021/acs.jmedchem.6b00972
	CHEMBL3903779	144219	None	0	Human	Functional	pKi	=	8.7	8.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	506	7	0	6	5.6	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CC2CCC(C1)O2	10.1021/acs.jmedchem.6b00972
	16123136	16283	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224638	16283	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	16123138	16294	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	396	7	1	3	4.4	C=CCN1C[C@H]2C[C@@]2(c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2)C1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224698	16294	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	396	7	1	3	4.4	C=CCN1C[C@H]2C[C@@]2(c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2)C1	10.1016/j.bmcl.2010.07.073
	11562199	98044	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4nc(C(C)(F)F)oc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL272775	98044	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	488	7	0	9	4.6	Cc1ncoc1-c1nnc(SCCCN2CCc3ccc4nc(C(C)(F)F)oc4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	44517726	198478	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	341	4	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL560177	198478	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	341	4	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	45267480	198804	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	409	4	0	2	4.5	O=C1N(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL562464	198804	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	409	4	0	2	4.5	O=C1N(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	45268438	198985	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	295	6	0	2	2.9	CCN(CC)CCN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.043
	CHEMBL563635	198985	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	295	6	0	2	2.9	CCN(CC)CCN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.043
	45267471	199021	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	319	4	0	2	3.1	O=C1N(CCN2C[C@H]3CC[C@@H]2C3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL563860	199021	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	319	4	0	2	3.1	O=C1N(CCN2C[C@H]3CC[C@@H]2C3)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	44627468	6291	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081747	6291	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	24758715	17805	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4ccc(Br)cc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258833	17805	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4ccc(Br)cc43)C2)n1C	10.1021/jm100832d
	11569996	95365	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	525	7	0	8	5.4	CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256477	95365	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	525	7	0	8	5.4	CCc1nn(C)c2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11497411	97804	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	7	0	8	6.1	CCc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL271631	97804	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	7	0	8	6.1	CCc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	45271510	197827	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.3	CC1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL551914	197827	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.3	CC1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	45271548	198350	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.0	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559029	198350	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	375	4	0	2	4.0	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	45267254	198444	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	332	4	0	3	2.8	N#Cc1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559856	198444	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	332	4	0	3	2.8	N#Cc1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	44517726	198478	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	341	4	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL560177	198478	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	341	4	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.028
	23631001	92908	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	460	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccn4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243898	92908	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	460	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccn4)n2C)CC3)no1	10.1021/jm0705612
	23630499	93000	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccc4Cl)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244087	93000	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	493	7	0	7	5.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccccc4Cl)n2C)CC3)no1	10.1021/jm0705612
	23631544	93320	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	490	8	0	9	4.4	COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cn1	10.1021/jm0705612
	CHEMBL244945	93320	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	490	8	0	9	4.4	COc1ccc(-c2nnc(SCCCN3CCc4ccc(-c5cc(C)on5)cc4CC3)n2C)cn1	10.1021/jm0705612
	134150637	151654	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	522	7	1	6	4.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCN(C(N)=O)CC1	10.1021/acs.jmedchem.6b00972
	CHEMBL3963243	151654	None	0	Human	Functional	pKi	=	8.6	8.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	522	7	1	6	4.5	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1C1CCN(C(N)=O)CC1	10.1021/acs.jmedchem.6b00972
	121315197	144820	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	491	8	0	7	5.5	Cc1ncoc1-c1nnc(SCCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3908862	144820	None	0	Human	Functional	pKi	=	7.7	7.7	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	491	8	0	7	5.5	Cc1ncoc1-c1nnc(SCCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	16123347	16022	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	355	5	1	3	3.6	CC(C)c1ccc(S(=O)(=O)Cc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223598	16022	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	355	5	1	3	3.6	CC(C)c1ccc(S(=O)(=O)Cc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	16123467	16024	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	355	5	1	3	3.6	CC(C)c1ccc(CS(=O)(=O)c2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223600	16024	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	355	5	1	3	3.6	CC(C)c1ccc(CS(=O)(=O)c2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	11663578	97928	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	518	7	0	11	4.2	Cc1cc(-c2nc3c4c(ccc3o2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)CC4)n(C)n1	10.1016/j.bmcl.2007.12.042
	CHEMBL272297	97928	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	518	7	0	11	4.2	Cc1cc(-c2nc3c4c(ccc3o2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)CC4)n(C)n1	10.1016/j.bmcl.2007.12.042
	45267492	198863	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	387	4	0	2	4.5	CC1(C)[C@@H]2CC[C@]13CCN(CCN1CCN(c4cccc(Cl)c4)C1=O)C3C2	10.1016/j.bmcl.2009.06.043
	CHEMBL562833	198863	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	387	4	0	2	4.5	CC1(C)[C@@H]2CC[C@]13CCN(CCN1CCN(c4cccc(Cl)c4)C1=O)C3C2	10.1016/j.bmcl.2009.06.043
	45267503	199174	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	369	6	0	2	4.4	Cc1ccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)cc1	10.1016/j.bmcl.2009.06.043
	CHEMBL564948	199174	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	369	6	0	2	4.4	Cc1ccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)cc1	10.1016/j.bmcl.2009.06.043
	44627242	6120	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080846	6120	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	44626632	6188	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	455	7	0	6	5.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccccc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081203	6188	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	455	7	0	6	5.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccccc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627359	6317	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081868	6317	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1204409	6317	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(F)cc(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	11585034	95221	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	576	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255806	95221	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	576	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11562113	95399	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	483	7	0	7	5.0	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(F)c(F)c2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256651	95399	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	483	7	0	7	5.0	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(F)c(F)c2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11692376	97487	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	8	0	8	6.3	CCc1nc2cc3c(c(C)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL269994	97487	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	8	0	8	6.3	CCc1nc2cc3c(c(C)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11620847	97958	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	7	0	7	5.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272478	97958	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	540	7	0	7	5.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11591601	155423	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL403181	155423	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1noc2cc3c(cc12)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11533429	169082	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	501	6	0	7	5.5	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL439065	169082	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	501	6	0	7	5.5	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	46881408	6760	None	0	Human	Functional	pKi	=	7.6	7.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	339	4	0	2	3.6	O=C1N(CCN2CCCCCC2)CCN1c1ccc(F)c(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1083813	6760	None	0	Human	Functional	pKi	=	7.6	7.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	339	4	0	2	3.6	O=C1N(CCN2CCCCCC2)CCN1c1ccc(F)c(Cl)c1	10.1016/j.bmcl.2010.01.090
	23631368	92998	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	460	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccncc4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL244085	92998	None	0	Human	Functional	pKi	=	7.6	7.6	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	460	7	0	8	4.4	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccncc4)n2C)CC3)no1	10.1021/jm0705612
	16123349	16296	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	382	4	2	3	3.4	O=S(=O)(Nc1ccc([C@]23CNC[C@H]2C3)cc1)c1ccc(C(F)(F)F)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224700	16296	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	382	4	2	3	3.4	O=S(=O)(Nc1ccc([C@]23CNC[C@H]2C3)cc1)c1ccc(C(F)(F)F)cc1	10.1016/j.bmcl.2010.07.073
	44454351	160701	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL411293	160701	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	551	6	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5nc6cc(C(F)(F)F)ccn6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	44627120	6046	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	CHEMBL1080489	6046	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	49781039	17591	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	CHEMBL1258153	17591	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	44454167	95361	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	8	0	9	5.2	COCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256472	95361	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	8	0	9	5.2	COCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454192	97539	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL270239	97539	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454400	97653	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	7	4.9	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL270853	97653	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	7	4.9	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454309	97692	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	514	6	1	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271066	97692	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	514	6	1	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCC(=O)N6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454219	155157	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	8	5.5	CCc1nc2cc3c(c(C)c2o1)CCN(CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL401777	155157	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	8	5.5	CCc1nc2cc3c(c(C)c2o1)CCN(CCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	46882054	6243	None	0	Human	Functional	pKi	=	6.6	6.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	305	4	0	2	2.9	O=C1N(CCN2CCCCCC2)CCN1c1ccc(F)cc1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081491	6243	None	0	Human	Functional	pKi	=	6.6	6.6	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	305	4	0	2	2.9	O=C1N(CCN2CCCCCC2)CCN1c1ccc(F)cc1	10.1016/j.bmcl.2010.01.090
	45268999	198437	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	378	4	0	4	3.9	Cc1nc2cc(N3CCN(CCN4Cc5ccccc5C4)C3=O)ccc2s1	10.1016/j.bmcl.2009.06.028
	CHEMBL559780	198437	None	0	Human	Functional	pKi	=	6.6	6.6	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	378	4	0	4	3.9	Cc1nc2cc(N3CCN(CCN4Cc5ccccc5C4)C3=O)ccc2s1	10.1016/j.bmcl.2009.06.028
	44454278	95594	None	0	Human	Functional	pKi	=	5.6	5.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	454	6	1	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL257536	95594	None	0	Human	Functional	pKi	=	5.6	5.6	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	454	6	1	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)OCC(=O)N4)n1C	10.1016/j.bmcl.2007.12.066
	11641641	97560	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	487	6	0	7	5.2	Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1	10.1016/j.bmcl.2007.12.042
	CHEMBL270387	97560	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	487	6	0	7	5.2	Cn1c(SCCCN2CCc3ccc4oc(C(F)(F)F)nc4c3CC2)nnc1-c1ccccc1	10.1016/j.bmcl.2007.12.042
	45270903	199190	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	347	4	0	2	3.7	O=C1N(CCN2C[C@H]3CC[C@H](CC3)C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL565075	199190	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	347	4	0	2	3.7	O=C1N(CCN2C[C@H]3CC[C@H](CC3)C2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	44626527	5889	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	CHEMBL1079494	5889	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	44627024	5946	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079823	5946	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	451	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(C)(C)C)cc3)C2)n1C	10.1021/jm901319p
	44627242	6120	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1080846	6120	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.8	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)c(Cl)c3)C2)n1C	10.1021/jm901319p
	49781040	17624	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	495	8	1	7	5.1	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4F)CC23)n1C	10.1021/jm100832d
	CHEMBL1258268	17624	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	495	8	1	7	5.1	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4F)CC23)n1C	10.1021/jm100832d
	11627847	95269	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256015	95269	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11613587	97703	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	542	7	0	9	5.2	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(F)(F)C(F)(F)F)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL271083	97703	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	542	7	0	9	5.2	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(C(F)(F)C(F)(F)F)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	45271520	197400	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	400	6	0	4	2.9	CC(C)N1CCN(CCN2CCN(c3cccc(OC(F)(F)F)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL549894	197400	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	400	6	0	4	2.9	CC(C)N1CCN(CCN2CCN(c3cccc(OC(F)(F)F)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	23631000	92907	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	527	7	0	7	6.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243897	92907	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	527	7	0	7	6.0	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)no1	10.1021/jm0705612
	23630797	93155	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	465	7	0	8	5.1	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)o1	10.1021/jm0705612
	CHEMBL244275	93155	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	465	7	0	8	5.1	Cc1cnc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4cccs4)n2C)CC3)o1	10.1021/jm0705612
	23630604	144283	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1ccccc1-c1nnc(SCCCN2CCc3ccc(-c4cc(C)on4)cc3CC2)n1C	10.1021/jm0705612
	CHEMBL390429	144283	None	0	Human	Functional	pKi	=	8.5	8.5	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	489	8	0	8	5.0	COc1ccccc1-c1nnc(SCCCN2CCc3ccc(-c4cc(C)on4)cc3CC2)n1C	10.1021/jm0705612
	46882458	5980	None	0	Human	Functional	pKi	=	8.4	8.4	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5980	None	0	Human	Functional	pKi	=	8.4	8.4	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	143	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	5311096	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	CHEMBL85606	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.042
	49865623	16038	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc(C34CNCC3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223657	16038	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	356	5	2	3	3.5	CC(C)c1ccc(S(=O)(=O)Nc2ccc(C34CNCC3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	11497680	97905	None	7	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL272150	97905	None	7	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11721190	155364	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL402853	155364	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(-c7cc(C)nn7C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11677768	155664	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	502	6	0	8	4.9	Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL404404	155664	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	502	6	0	8	4.9	Cc1ccc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	143	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2009.06.043
	5311096	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2009.06.043
	CHEMBL85606	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2009.06.043
	143	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm901319p
	5311096	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm901319p
	CHEMBL85606	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm901319p
	44626639	5890	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	533	7	0	6	5.9	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Br)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1079497	5890	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	533	7	0	6	5.9	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Br)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627353	6364	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1082111	6364	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cc(C(F)(F)F)ccc3F)C2)n1C	10.1021/jm901319p
	11497680	97905	None	7	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL272150	97905	None	7	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C(F)(F)F)nc6c5CC4)n3C)cccc2n1	10.1021/jm901319p
	52947694	17493	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)CC2)n1C	10.1021/jm100832d
	CHEMBL1257809	17493	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)CC2)n1C	10.1021/jm100832d
	52949300	17529	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	521	7	0	7	6.1	Cc1nc(C)c(-c2nnc(SCCCN3CCC4CC4(c4ccc(C(F)(F)F)cc4)CC3)n2C)s1	10.1021/jm100832d
	CHEMBL1257926	17529	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	521	7	0	7	6.1	Cc1nc(C)c(-c2nnc(SCCCN3CCC4CC4(c4ccc(C(F)(F)F)cc4)CC3)n2C)s1	10.1021/jm100832d
	52940961	17557	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	488	7	0	7	4.8	Cn1c(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)CC2)nnc1-c1ccnnc1	10.1021/jm100832d
	CHEMBL1258034	17557	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	488	7	0	7	4.8	Cn1c(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)CC2)nnc1-c1ccnnc1	10.1021/jm100832d
	49780809	17558	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	CHEMBL1258035	17558	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	8	1	7	5.0	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC[C@]3(c4ccc(C(F)(F)F)cc4)CC23)n1C	10.1021/jm100832d
	143	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	5311096	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	CHEMBL85606	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1016/j.bmcl.2007.12.066
	11576387	95179	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	468	7	0	9	4.5	CCc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL255567	95179	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	468	7	0	9	4.5	CCc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11526451	155151	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	518	7	0	11	4.2	Cc1cc(-c2nc3cc4c(cc3o2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)CC4)n(C)n1	10.1016/j.bmcl.2007.12.066
	CHEMBL401728	155151	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	518	7	0	11	4.2	Cc1cc(-c2nc3cc4c(cc3o2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)CC4)n(C)n1	10.1016/j.bmcl.2007.12.066
	11548217	155356	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	8	0	8	6.0	CCCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL402826	155356	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	8	0	8	6.0	CCCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	46882005	5848	None	0	Human	Functional	pKi	=	8.4	8.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	307	3	0	2	3.1	CN1CCCCC1CN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2010.01.090
	CHEMBL1079190	5848	None	0	Human	Functional	pKi	=	8.4	8.4	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	307	3	0	2	3.1	CN1CCCCC1CN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2010.01.090
	46881463	7220	None	0	Human	Functional	pKi	=	8.4	8.4	-	3	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1085672	7220	None	0	Human	Functional	pKi	=	8.4	8.4	-	3	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	293	3	1	2	2.7	O=C1N(CC2CCCCN2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	45272434	200179	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	341	5	0	4	1.8	CC(C)N1CCN(CCN2CCN(c3cccc(C#N)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL571456	200179	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	341	5	0	4	1.8	CC(C)N1CCN(CCN2CCN(c3cccc(C#N)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	143	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm0705612
	5311096	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm0705612
	CHEMBL85606	3515	None	36	Human	Functional	pKi	=	8.4	8.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10.1021/jm0705612
	23631636	92906	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	484	7	0	8	4.9	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C#N)cc4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243896	92906	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	484	7	0	8	4.9	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C#N)cc4)n2C)CC3)no1	10.1021/jm0705612
	46882521	5713	None	0	Human	Functional	pKi	=	7.5	7.5	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5713	None	0	Human	Functional	pKi	=	7.5	7.5	-	2	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	11577158	97860	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL271909	97860	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	514	6	0	8	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C)sc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	45271760	198016	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	399	6	0	3	4.9	CN(CCN1CCN(c2cccc(Cl)c2)C1=O)Cc1cc2ccccc2s1	10.1016/j.bmcl.2009.06.043
	CHEMBL554738	198016	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	399	6	0	3	4.9	CN(CCN1CCN(c2cccc(Cl)c2)C1=O)Cc1cc2ccccc2s1	10.1016/j.bmcl.2009.06.043
	44626641	5903	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	480	7	0	7	5.0	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C#N)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1079577	5903	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	480	7	0	7	5.0	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(C#N)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44626738	5904	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079578	5904	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	44627238	6002	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccccc3C(F)(F)F)C2)n1C	10.1021/jm901319p
	CHEMBL1080189	6002	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccccc3C(F)(F)F)C2)n1C	10.1021/jm901319p
	24758832	17731	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1ccc2c(c1)C1(CCC2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	CHEMBL1258605	17731	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1ccc2c(c1)C1(CCC2)CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	24758947	17806	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	473	6	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5ccc(Cl)cc54)C3)n2C)s1	10.1021/jm100832d
	CHEMBL1258834	17806	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	473	6	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5ccc(Cl)cc54)C3)n2C)s1	10.1021/jm100832d
	24758481	17835	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	473	6	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5cc(Cl)ccc54)C3)n2C)s1	10.1021/jm100832d
	CHEMBL1258948	17835	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	473	6	0	7	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5cc(Cl)ccc54)C3)n2C)s1	10.1021/jm100832d
	52945023	55296	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	495	8	1	7	5.1	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm100832d
	CHEMBL1258269	55296	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	495	8	1	7	5.1	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm100832d
	CHEMBL1618255	55296	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	495	8	1	7	5.1	Cc1ncoc1-c1nnc(SCCCN[C@@H]2CC3C[C@]3(c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/jm100832d
	11496746	95398	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	484	5	0	8	5.0	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256650	95398	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	484	5	0	8	5.0	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11511117	97488	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	469	6	0	7	4.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(F)c(F)c2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL269995	97488	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	469	6	0	7	4.8	Cc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(F)c(F)c2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11539722	97985	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	452	7	0	9	4.1	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL272546	97985	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	452	7	0	9	4.1	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11692214	155155	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	5.9	CCc1nc2cc3c(c(C)c2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL401752	155155	None	0	Human	Functional	pKi	=	7.5	7.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	5.9	CCc1nc2cc3c(c(C)c2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454150	155531	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	532	6	0	8	6.0	Cc1ccc2c(-c3nnc(SCCCN4CCc5c(Cl)cc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL403815	155531	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	532	6	0	8	6.0	Cc1ccc2c(-c3nnc(SCCCN4CCc5c(Cl)cc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	24849462	202214	None	0	Human	Functional	pKi	=	6.5	6.5	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	339	3	0	3	4.6	Cn1c(CN2CCC(c3ccc(Cl)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL593744	202214	None	0	Human	Functional	pKi	=	6.5	6.5	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	339	3	0	3	4.6	Cn1c(CN2CCC(c3ccc(Cl)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	44627468	6291	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081747	6291	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	44454218	95680	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	5	0	8	5.3	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257901	95680	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	5	0	8	5.3	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454402	97695	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	452	7	0	9	4.2	Cc1nc2cc3c(cc2o1)CCN(CCCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL271073	97695	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	452	7	0	9	4.2	Cc1nc2cc3c(cc2o1)CCN(CCCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	44454275	155209	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	562	5	0	8	5.7	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL402015	155209	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	562	5	0	8	5.7	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454247	157812	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	616	5	0	8	6.5	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL408208	157812	None	0	Human	Functional	pKi	=	6.5	6.5	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	616	5	0	8	6.5	Cc1ccc2c(-c3nnc(SCCN4CCc5cc6nc(C(F)(F)F)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46881412	6859	None	0	Human	Functional	pKi	=	6.5	6.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	357	4	0	3	2.6	O=S1(=O)N(CCN2CCCCCC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1084121	6859	None	0	Human	Functional	pKi	=	6.5	6.5	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	357	4	0	3	2.6	O=S1(=O)N(CCN2CCCCCC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	45269235	198865	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	373	6	0	2	4.2	CN(CCN1CCN(c2ccc(F)cc2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	CHEMBL562836	198865	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	373	6	0	2	4.2	CN(CCN1CCN(c2ccc(F)cc2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	44626740	5992	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1080117	5992	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44626734	6194	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081237	6194	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	523	7	0	6	6.4	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)c(Cl)c5)C4)n3C)cccc2n1	10.1021/jm901319p
	52941427	17457	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4ccc(C(F)(F)F)cc4)CC3C2)n1C	10.1021/jm100832d
	CHEMBL1257686	17457	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4ccc(C(F)(F)F)cc4)CC3C2)n1C	10.1021/jm100832d
	11547466	95186	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	478	8	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(CC5CC5)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL255619	95186	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	478	8	0	9	4.5	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4nc(CC5CC5)oc4cc3CC2)n1C	10.1016/j.bmcl.2007.12.066
	11585248	95367	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	604	8	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256482	95367	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	604	8	0	8	6.8	CCc1nc2cc3c(c(Br)c2o1)CCN(CCCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11627879	95400	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	6	0	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256652	95400	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	528	6	0	8	4.3	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)N(C)C(=O)CO6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11613873	95728	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	566	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(CC(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL258090	95728	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	566	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(CC(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11606456	97652	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	8	0	7	5.7	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL270852	97652	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	8	0	7	5.7	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6c(cc5CC4)C(=O)N(C(C)C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11664328	97694	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	590	7	0	8	6.5	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271072	97694	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	590	7	0	8	6.5	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11663504	98023	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	8	5.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272694	98023	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	8	5.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	44454401	155230	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	6	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL402087	155230	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	554	6	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(C)C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	45270702	197681	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	393	4	0	2	4.0	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(Cl)c1F	10.1016/j.bmcl.2009.06.028
	CHEMBL550849	197681	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	393	4	0	2	4.0	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(Cl)c1F	10.1016/j.bmcl.2009.06.028
	45268990	198384	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	365	6	0	3	3.7	CC(C)Oc1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559386	198384	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	365	6	0	3	3.7	CC(C)Oc1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	23630503	92909	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	397	6	0	7	3.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243899	92909	None	0	Human	Functional	pKi	=	7.4	7.4	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	397	6	0	7	3.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C)n2C)CC3)no1	10.1021/jm0705612
	44454318	97779	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	491	6	0	9	4.0	Cc1ncoc1-c1nnc(SCCCN2CCc3nc4ccc(C(F)(F)F)cn4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	CHEMBL271511	97779	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	491	6	0	9	4.0	Cc1ncoc1-c1nnc(SCCCN2CCc3nc4ccc(C(F)(F)F)cn4c3CC2)n1C	10.1016/j.bmcl.2007.12.042
	44627131	5978	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1079980	5978	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(F)c3)C2)n1C	10.1021/jm901319p
	44627025	6362	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1082106	6362	None	0	Human	Functional	pKi	=	6.4	6.4	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	473	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Br)cc3)C2)n1C	10.1021/jm901319p
	46225583	202630	None	0	Human	Functional	pKi	=	5.4	5.4	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	362	3	0	5	4.6	Cn1c(CN2CCC(c3nsc4ccccc34)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL596527	202630	None	0	Human	Functional	pKi	=	5.4	5.4	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	362	3	0	5	4.6	Cn1c(CN2CCC(c3nsc4ccccc34)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	121304574	143120	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	503	7	0	7	4.6	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccn(C)c(=O)c1	10.1021/acs.jmedchem.6b00972
	CHEMBL3894853	143120	None	0	Human	Functional	pKi	=	8.4	8.4	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	503	7	0	7	4.6	Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)nnc1-c1ccn(C)c(=O)c1	10.1021/acs.jmedchem.6b00972
	16123353	16025	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	370	7	2	3	3.7	CCCCc1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223601	16025	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	370	7	2	3	3.7	CCCCc1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	11642163	97558	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	522	6	0	9	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1	10.1016/j.bmcl.2007.12.042
	CHEMBL270376	97558	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	522	6	0	9	5.3	Cc1nc(C)c(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)s1	10.1016/j.bmcl.2007.12.042
	11497679	155654	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL404363	155654	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6nc(C(F)(F)F)oc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	45273545	198956	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	385	7	0	3	4.1	COc1cccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL563435	198956	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	385	7	0	3	4.1	COc1cccc(N2CCN(CCN(C)C[C@]34CC[C@H](CC3)C4(C)C)C2=O)c1	10.1016/j.bmcl.2009.06.043
	44627127	5881	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1079461	5881	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(Cl)c3)C2)n1C	10.1021/jm901319p
	44626527	5889	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	CHEMBL1079494	5889	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	459	8	0	8	4.2	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1Cl	10.1021/jm901319p
	44627033	5950	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079837	5950	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)cc1	10.1021/jm901319p
	44627131	5978	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1079980	5978	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(F)c3)C2)n1C	10.1021/jm901319p
	44626632	6188	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	455	7	0	6	5.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccccc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1081203	6188	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	455	7	0	6	5.1	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccccc5)C4)n3C)cccc2n1	10.1021/jm901319p
	49781255	17766	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4cc(Br)ccc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258712	17766	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4cc(Br)ccc43)C2)n1C	10.1021/jm100832d
	11555971	95224	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	567	7	0	9	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(N7CCCCC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL255826	95224	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	567	7	0	9	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(N7CCCCC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11628631	97536	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)C(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL270227	97536	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	602	7	0	8	6.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)C(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882004	5606	None	0	Human	Functional	pKi	=	8.3	8.3	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	321	4	0	2	3.5	O=C1N(CCN2CCCCCC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1077344	5606	None	0	Human	Functional	pKi	=	8.3	8.3	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	321	4	0	2	3.5	O=C1N(CCN2CCCCCC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2010.01.090
	45268141	198450	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	425	5	0	3	4.1	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(OC(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL559919	198450	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	425	5	0	3	4.1	O=C1N(CCN2CCC(C(F)(F)F)CC2)CCN1c1cccc(OC(F)(F)F)c1	10.1016/j.bmcl.2009.06.028
	11705570	92261	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	474	6	0	9	3.5	Cc1cnc(-c2nnc(SCCN3CCc4ccc(-c5cc(C)nn5C)cc4CC3)n2C)cn1	10.1021/jm0705612
	CHEMBL242601	92261	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	474	6	0	9	3.5	Cc1cnc(-c2nnc(SCCN3CCc4ccc(-c5cc(C)nn5C)cc4CC3)n2C)cn1	10.1021/jm0705612
	23631093	92625	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	439	6	0	7	4.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(C)(C)C)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243474	92625	None	0	Human	Functional	pKi	=	8.3	8.3	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	439	6	0	7	4.7	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(C(C)(C)C)n2C)CC3)no1	10.1021/jm0705612
	45268345	198592	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	417	5	0	2	5.1	O=C1N(CCN2CCC(c3ccc(Cl)cc3)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL561128	198592	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	417	5	0	2	5.1	O=C1N(CCN2CCC(c3ccc(Cl)cc3)CC2)CCN1c1cccc(Cl)c1	10.1016/j.bmcl.2009.06.043
	45268373	199100	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	399	6	0	4	3.8	CN(CCN1CCN(c2ccc3c(c2)OCO3)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	CHEMBL564347	199100	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	399	6	0	4	3.8	CN(CCN1CCN(c2ccc3c(c2)OCO3)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	44626935	6256	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081580	6256	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	463	7	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2C[C@H]3C[C@@]3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	44626530	6329	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081934	6329	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(OC(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	44627240	6332	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1081966	6332	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	479	8	0	8	4.4	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(OC(F)(F)F)cc3)C2)n1C	10.1021/jm901319p
	24758945	17309	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	457	6	0	7	4.8	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5ccc(F)cc54)C3)n2C)s1	10.1021/jm100832d
	CHEMBL1257214	17309	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	457	6	0	7	4.8	Cc1nc(C)c(-c2nnc(SCCCN3CCC4(CCc5ccc(F)cc54)C3)n2C)s1	10.1021/jm100832d
	49780808	17341	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	8	1	7	4.0	Cc1ncoc1-c1nnc(SCCCNC2CC3CC3(c3ccccc3)C2)n1C	10.1021/jm100832d
	CHEMBL1257335	17341	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	409	8	1	7	4.0	Cc1ncoc1-c1nnc(SCCCNC2CC3CC3(c3ccccc3)C2)n1C	10.1021/jm100832d
	49781477	17343	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.7	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2cccc(C(F)(F)F)c2)C3)n1C	10.1021/jm100832d
	CHEMBL1257337	17343	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	491	7	0	7	5.7	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2cccc(C(F)(F)F)c2)C3)n1C	10.1021/jm100832d
	11641596	97851	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	484	6	0	8	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271844	97851	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	484	6	0	8	5.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6ncoc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11526531	98024	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C7CC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272695	98024	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	524	7	0	8	5.9	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C7CC7)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11527195	98111	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	590	6	0	8	6.5	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL273165	98111	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	590	6	0	8	6.5	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C)oc6c(Br)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11606435	155210	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL402016	155210	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	552	6	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882050	6239	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	317	5	0	3	2.8	COc1cccc(N2CCN(CCN3CCCCCC3)C2=O)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081487	6239	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	317	5	0	3	2.8	COc1cccc(N2CCN(CCN3CCCCCC3)C2=O)c1	10.1016/j.bmcl.2010.01.090
	46225569	203819	None	0	Human	Functional	pKi	=	6.3	6.3	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	373	3	0	3	5.0	Cn1c(CN2CCC(c3ccccc3C(F)(F)F)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	CHEMBL604467	203819	None	0	Human	Functional	pKi	=	6.3	6.3	-	2	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	373	3	0	3	5.0	Cn1c(CN2CCC(c3ccccc3C(F)(F)F)CC2)nc2ccccc21	10.1016/j.bmcl.2009.11.032
	44627129	5882	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079462	5882	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	44627123	6047	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1080490	6047	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	429	7	0	7	4.2	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3)C2)n1C	10.1021/jm901319p
	45272411	197338	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	388	4	0	4	3.6	CC(=O)n1ccc2cc(N3CCN(CCN4Cc5ccccc5C4)C3=O)ccc21	10.1016/j.bmcl.2009.06.028
	CHEMBL549759	197338	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	388	4	0	4	3.6	CC(=O)n1ccc2cc(N3CCN(CCN4Cc5ccccc5C4)C3=O)ccc21	10.1016/j.bmcl.2009.06.028
	45269860	197749	None	1	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccccc1Cl	10.1016/j.bmcl.2009.06.028
	CHEMBL551386	197749	None	1	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	355	5	0	2	3.6	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccccc1Cl	10.1016/j.bmcl.2009.06.028
	45272425	199148	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	403	5	0	2	4.5	CC(c1cccc(C(F)(F)F)c1)N1CCN(CCN2Cc3ccccc3C2)C1=O	10.1016/j.bmcl.2009.06.028
	CHEMBL564741	199148	None	0	Human	Functional	pKi	=	6.3	6.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	403	5	0	2	4.5	CC(c1cccc(C(F)(F)F)c1)N1CCN(CCN2Cc3ccccc3C2)C1=O	10.1016/j.bmcl.2009.06.028
	46190877	1871	None	8	Human	Functional	pKi	=	5.3	5.3	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	409	3	0	5	4.0	Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F	10.1016/j.bmcl.2009.11.032
	6252	1871	None	8	Human	Functional	pKi	=	5.3	5.3	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	409	3	0	5	4.0	Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F	10.1016/j.bmcl.2009.11.032
	CHEMBL605836	1871	None	8	Human	Functional	pKi	=	5.3	5.3	-	1	Antagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells co-expressing G0 by [35S]GTPgammaS binding assay	ChEMBL	409	3	0	5	4.0	Clc1cc(cnc1N1CCN(CC1)Cc1nc2c(n1C)cccc2)C(F)(F)F	10.1016/j.bmcl.2009.11.032
	121315259	148389	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	463	6	0	7	4.8	Cc1ncoc1-c1nnc(SCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3936812	148389	None	0	Human	Functional	pKi	=	7.3	7.3	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	463	6	0	7	4.8	Cc1ncoc1-c1nnc(SCCN2CC[C@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	16123462	16026	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	384	6	2	3	4.0	CCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223602	16026	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	384	6	2	3	4.0	CCC(C)(C)c1ccc(S(=O)(=O)Nc2ccc([C@]34CNC[C@H]3C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	16123241	16284	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	370	5	1	3	3.8	CC(C)c1ccc(S(=O)(=O)Nc2ccc([C@@]34C[C@@H]3CN(C)C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224639	16284	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	370	5	1	3	3.8	CC(C)c1ccc(S(=O)(=O)Nc2ccc([C@@]34C[C@@H]3CN(C)C4)cc2)cc1	10.1016/j.bmcl.2010.07.073
	11533473	97604	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	503	6	0	9	4.3	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL270602	97604	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	503	6	0	9	4.3	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5oc(C(F)(F)F)nc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	44454418	155527	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	468	7	0	9	4.5	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL403804	155527	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	468	7	0	9	4.5	CCc1nc2ccc3c(c2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.042
	45272634	198930	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	6	0	2	4.7	CN(CCN1CCN(c2cccc(Cl)c2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	CHEMBL563274	198930	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	389	6	0	2	4.7	CN(CCN1CCN(c2cccc(Cl)c2)C1=O)C[C@]12CC[C@H](CC1)C2(C)C	10.1016/j.bmcl.2009.06.043
	44627129	5882	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079462	5882	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	44626738	5904	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	CHEMBL1079578	5904	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	485	8	0	7	5.1	COc1ccc(C23CC2CN(CCCSc2nnc(-c4cccc5nc(C)ccc45)n2C)C3)cc1	10.1021/jm901319p
	44626740	5992	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL1080117	5992	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	489	7	0	6	5.7	Cc1ccc2c(-c3nnc(SCCCN4CC5CC5(c5ccc(Cl)cc5)C4)n3C)cccc2n1	10.1021/jm901319p
	44627468	6291	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	CHEMBL1081747	6291	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	447	7	0	7	4.3	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(Cl)cc3F)C2)n1C	10.1021/jm901319p
	49781478	17378	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	509	7	0	7	5.8	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(F)(F)F)cc2F)C3)n1C	10.1021/jm100832d
	CHEMBL1257448	17378	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	509	7	0	7	5.8	Cc1ncoc1-c1nnc(SCCCN2[C@H]3CC[C@@H]2C[C@H](c2ccc(C(F)(F)F)cc2F)C3)n1C	10.1021/jm100832d
	52940753	17492	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4cccc(C(F)(F)F)c4)CC3C2)n1C	10.1021/jm100832d
	CHEMBL1257808	17492	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3(c4cccc(C(F)(F)F)c4)CC3C2)n1C	10.1021/jm100832d
	11656848	95362	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256473	95362	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	548	7	0	8	6.2	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(C)(F)F)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11699340	95366	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL256481	95366	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	526	7	0	8	6.1	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	45273334	195379	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	349	5	0	2	4.1	CC(C)c1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL540241	195379	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	349	5	0	2	4.1	CC(C)c1cccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)c1	10.1016/j.bmcl.2009.06.028
	45272426	197898	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.3	CC1CCCN(CCN2CCN(c3cccc(Cl)c3)C2=O)C1	10.1016/j.bmcl.2009.06.028
	CHEMBL552371	197898	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.3	CC1CCCN(CCN2CCN(c3cccc(Cl)c3)C2=O)C1	10.1016/j.bmcl.2009.06.028
	45268119	199185	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(Cl)ccc1F	10.1016/j.bmcl.2009.06.028
	CHEMBL565031	199185	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	359	4	0	2	3.7	O=C1N(CCN2Cc3ccccc3C2)CCN1c1cc(Cl)ccc1F	10.1016/j.bmcl.2009.06.028
	23630998	92870	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	539	7	0	9	5.6	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5nc(C)c(C)nc5c4)n2C)CC3)no1	10.1021/jm0705612
	CHEMBL243708	92870	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	539	7	0	9	5.6	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc5nc(C)c(C)nc5c4)n2C)CC3)no1	10.1021/jm0705612
	121304424	143931	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	495	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3901587	143931	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	495	7	0	7	5.3	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@@H]3c3ccc(C(F)(F)F)cc3F)C2)n1C	10.1021/acs.jmedchem.6b00972
	121304458	154078	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	409	7	0	7	4.1	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccccc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	CHEMBL3983937	154078	None	0	Human	Functional	pKi	=	8.2	8.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor expressed in CHO cell membranes after 90 mins in presence of quinelorane by [35S]-GTPgammaS binding assay	ChEMBL	409	7	0	7	4.1	Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccccc3)C2)n1C	10.1021/acs.jmedchem.6b00972
	11656243	97970	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	CHEMBL272511	97970	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.042
	11518933	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	CHEMBL269959	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	11656243	97970	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	CHEMBL272511	97970	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc6oc(C)nc6c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2009.06.043
	44627355	5968	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	CHEMBL1079938	5968	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3cccc(C(F)(F)F)c3F)C2)n1C	10.1021/jm901319p
	11518933	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1021/jm901319p
	CHEMBL269959	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1021/jm901319p
	11669953	95593	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	468	6	0	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C	10.1016/j.bmcl.2007.12.066
	CHEMBL257534	95593	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	468	6	0	9	2.7	Cc1ncoc1-c1nnc(SCCCN2CCc3cc4c(cc3CC2)N(C)C(=O)CO4)n1C	10.1016/j.bmcl.2007.12.066
	11518933	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL269959	97477	None	7	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	498	6	0	8	5.4	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11548755	97708	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	580	7	0	8	6.8	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL271097	97708	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	580	7	0	8	6.8	Cc1ccc2c(-c3nnc(SCCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882052	6241	None	0	Human	Functional	pKi	=	7.2	7.2	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	287	4	0	2	2.8	O=C1N(CCN2CCCCCC2)CCN1c1ccccc1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081489	6241	None	0	Human	Functional	pKi	=	7.2	7.2	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	287	4	0	2	2.8	O=C1N(CCN2CCCCCC2)CCN1c1ccccc1	10.1016/j.bmcl.2010.01.090
	45273272	198117	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	3	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc2sccc2c1	10.1016/j.bmcl.2009.06.028
	CHEMBL556478	198117	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	363	4	0	3	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1c1ccc2sccc2c1	10.1016/j.bmcl.2009.06.028
	45268127	199115	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	322	4	0	3	2.6	Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)cn1	10.1016/j.bmcl.2009.06.028
	CHEMBL564477	199115	None	0	Human	Functional	pKi	=	7.2	7.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	322	4	0	3	2.6	Cc1ccc(N2CCN(CCN3Cc4ccccc4C3)C2=O)cn1	10.1016/j.bmcl.2009.06.028
	46882583	5758	None	0	Human	Functional	pKi	=	6.2	6.2	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	453	5	2	6	2.6	CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21	10.1016/j.bmcl.2009.09.027
	CHEMBL1078491	5758	None	0	Human	Functional	pKi	=	6.2	6.2	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	453	5	2	6	2.6	CN1CCOc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc21	10.1016/j.bmcl.2009.09.027
	45102708	5772	None	0	Human	Functional	pKi	=	6.2	6.2	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	468	6	2	7	2.0	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078595	5772	None	0	Human	Functional	pKi	=	6.2	6.2	-	1	Agonist activity at dopamine D3 receptorAgonist activity at dopamine D3 receptor	ChEMBL	468	6	2	7	2.0	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(N2CCOCC2)nc1	10.1016/j.bmcl.2009.09.027
	16123464	16297	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	398	5	2	4	3.2	O=S(=O)(Nc1ccc([C@]23CNC[C@H]2C3)cc1)c1ccc(OC(F)(F)F)cc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224701	16297	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	398	5	2	4	3.2	O=S(=O)(Nc1ccc([C@]23CNC[C@H]2C3)cc1)c1ccc(OC(F)(F)F)cc1	10.1016/j.bmcl.2010.07.073
	45273523	198122	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	413	6	0	3	4.5	COc1cccc(C2CCCN(CCN3CCN(c4cccc(Cl)c4)C3=O)C2)c1	10.1016/j.bmcl.2009.06.043
	CHEMBL556496	198122	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	413	6	0	3	4.5	COc1cccc(C2CCCN(CCN3CCN(c4cccc(Cl)c4)C3=O)C2)c1	10.1016/j.bmcl.2009.06.043
	44454434	97960	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	7	4.5	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL272480	97960	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	512	6	0	7	4.5	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)C(=O)N(C)C6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	45272412	198022	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	5	0	2	2.9	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccccc1	10.1016/j.bmcl.2009.06.028
	CHEMBL554914	198022	None	0	Human	Functional	pKi	=	6.2	6.2	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	5	0	2	2.9	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccccc1	10.1016/j.bmcl.2009.06.028
	16123140	16293	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	384	6	1	3	4.2	CCN1C[C@H]2C[C@@]2(c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2)C1	10.1016/j.bmcl.2010.07.073
	CHEMBL1224697	16293	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	384	6	1	3	4.2	CCN1C[C@H]2C[C@@]2(c2ccc(NS(=O)(=O)c3ccc(C(C)C)cc3)cc2)C1	10.1016/j.bmcl.2010.07.073
	11519133	169526	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	CHEMBL442456	169526	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	512	7	0	8	5.6	CCc1nc2c3c(ccc2o1)CCN(CCCSc1nnc(-c2cccc4nc(C)ccc24)n1C)CC3	10.1016/j.bmcl.2007.12.042
	44627129	5882	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	CHEMBL1079462	5882	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	413	7	0	7	3.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)cc3)C2)n1C	10.1021/jm901319p
	44627120	6046	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	CHEMBL1080489	6046	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	425	8	0	8	3.5	COc1cccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c1	10.1021/jm901319p
	49836026	17418	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm100832d
	CHEMBL1257566	17418	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	477	7	0	7	4.9	Cc1ncoc1-c1nnc(SCCCN2CCC3CC3(c3ccc(C(F)(F)F)cc3)C2)n1C	10.1021/jm100832d
	24758828	17657	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	501	6	0	7	5.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCCc4cc(Br)ccc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258380	17657	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	501	6	0	7	5.0	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCCc4cc(Br)ccc43)C2)n1C	10.1021/jm100832d
	24758717	17767	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4c(Br)cccc43)C2)n1C	10.1021/jm100832d
	CHEMBL1258713	17767	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	487	6	0	7	4.6	Cc1ncoc1-c1nnc(SCCCN2CCC3(CCc4c(Br)cccc43)C2)n1C	10.1021/jm100832d
	11628452	97594	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(-c7cc(C)nn7C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL270567	97594	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	578	7	0	10	5.8	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(-c7cc(C)nn7C)oc6cc5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	11591633	97707	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	515	7	0	7	5.8	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL271096	97707	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	515	7	0	7	5.8	CCc1nc2cc3c(cc2o1)CCN(CCCSc1nnc(-c2ccc(C(F)(F)F)cc2)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11584185	157772	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	500	6	1	8	4.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCCN6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL408169	157772	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	500	6	1	8	4.7	Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6c(cc5CC4)OCCN6)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	45271516	197984	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	384	4	0	3	3.2	N#Cc1cc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)ccc1F	10.1016/j.bmcl.2009.06.028
	CHEMBL554073	197984	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	384	4	0	3	3.2	N#Cc1cc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)ccc1F	10.1016/j.bmcl.2009.06.028
	45268148	198540	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	350	5	0	3	2.6	CC(C)N1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	CHEMBL560715	198540	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	350	5	0	3	2.6	CC(C)N1CCN(CCN2CCN(c3cccc(Cl)c3)C2=O)CC1	10.1016/j.bmcl.2009.06.028
	45267270	198581	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.5	CC1CCCCN1CCN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.028
	CHEMBL561054	198581	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	321	4	0	2	3.5	CC1CCCCN1CCN1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.028
	11584694	144533	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	540	7	0	7	5.8	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)n(C)n1	10.1021/jm0705612
	CHEMBL390649	144533	None	0	Human	Functional	pKi	=	8.1	8.1	-	0	Displacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 minsDisplacement of [35S]GTP-gamma-S from human cloned dopamine D3 receptor expressed in CHO cells after 30 mins	ChEMBL	540	7	0	7	5.8	Cc1cc(-c2ccc3c(c2)CCN(CCCSc2nnc(-c4ccc(C(F)(F)F)cc4)n2C)CC3)n(C)n1	10.1021/jm0705612
	49865589	16023	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	328	4	1	3	2.4	CN(c1ccc([C@]23CNC[C@H]2C3)cc1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.07.073
	CHEMBL1223599	16023	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	328	4	1	3	2.4	CN(c1ccc([C@]23CNC[C@H]2C3)cc1)S(=O)(=O)c1ccccc1	10.1016/j.bmcl.2010.07.073
	45273510	198056	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	309	4	0	3	2.6	COC[C@@H]1CCCN1N1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.043
	CHEMBL555744	198056	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAntagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	ChEMBL	309	4	0	3	2.6	COC[C@@H]1CCCN1N1CCN(c2cccc(Cl)c2)C1=O	10.1016/j.bmcl.2009.06.043
	44627351	6257	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	CHEMBL1081587	6257	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	481	7	0	7	4.7	Cc1ncoc1-c1nnc(SCCCN2CC3CC3(c3ccc(F)c(C(F)(F)F)c3)C2)n1C	10.1021/jm901319p
	44627466	6318	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	427	7	0	7	4.0	Cc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c(F)c1	10.1021/jm901319p
	CHEMBL1081869	6318	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assayAntagonist activity at human Dopamine D3 receptor expressed in CHO cell by GTPgammaS binding assay	ChEMBL	427	7	0	7	4.0	Cc1ccc(C23CC2CN(CCCSc2nnc(-c4ocnc4C)n2C)C3)c(F)c1	10.1021/jm901319p
	24758836	17696	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1cccc2c1CCCC21CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	CHEMBL1258493	17696	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS bindingAntagonist activity at human dopamine D3 expressed in CHO cells assessed as inhibition of quinelorane-induced [35S]GTPgammaS binding	ChEMBL	453	7	0	8	4.2	COc1cccc2c1CCCC21CCN(CCCSc2nnc(-c3ocnc3C)n2C)C1	10.1021/jm100832d
	11568714	95360	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	454	6	0	9	4.3	Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	CHEMBL256471	95360	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	454	6	0	9	4.3	Cc1nc2cc3c(cc2s1)CCN(CCCSc1nnc(-c2ocnc2C)n1C)CC3	10.1016/j.bmcl.2007.12.066
	11497924	95591	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	580	6	0	8	6.8	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	CHEMBL257525	95591	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayAntagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay	ChEMBL	580	6	0	8	6.8	Cc1ccc2c(-c3nnc(SCCC(C)N4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1	10.1016/j.bmcl.2007.12.066
	46882006	5849	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	321	4	0	2	3.5	O=C1N(CCN2CCCCCC2)CCN1c1ccc(Cl)cc1	10.1016/j.bmcl.2010.01.090
	CHEMBL1079191	5849	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	321	4	0	2	3.5	O=C1N(CCN2CCCCCC2)CCN1c1ccc(Cl)cc1	10.1016/j.bmcl.2010.01.090
	46882009	6216	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	301	4	0	2	3.1	Cc1cccc(N2CCN(CCN3CCCCCC3)C2=O)c1	10.1016/j.bmcl.2010.01.090
	CHEMBL1081311	6216	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	301	4	0	2	3.1	Cc1cccc(N2CCN(CCN3CCCCCC3)C2=O)c1	10.1016/j.bmcl.2010.01.090
	46881409	6761	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	288	4	0	3	2.2	O=C1N(CCN2CCCCCC2)CCN1c1cccnc1	10.1016/j.bmcl.2010.01.090
	CHEMBL1083814	6761	None	0	Human	Functional	pKi	=	7.1	7.1	-	1	Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assayAntagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinperol-induced [35S]GTPgamma binding by scintillation proximity affinity assay	ChEMBL	288	4	0	3	2.2	O=C1N(CCN2CCCCCC2)CCN1c1cccnc1	10.1016/j.bmcl.2010.01.090
	45267261	198534	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	CHEMBL560650	198534	None	0	Human	Functional	pKi	=	7.1	7.1	-	0	Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryAntagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometry	ChEMBL	389	5	0	2	4.2	O=C1N(CCN2Cc3ccccc3C2)CCN1Cc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2009.06.028
	44454443	97816	None	0	Human	Functional	pKi	=	6.1	6.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	449	6	0	9	3.6	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	CHEMBL271702	97816	None	0	Human	Functional	pKi	=	6.1	6.1	-	0	Antagonist activity at dopamine D3 receptor by GTPgammaS binding assayAntagonist activity at dopamine D3 receptor by GTPgammaS binding assay	ChEMBL	449	6	0	9	3.6	Cc1cnc(-c2nnc(SCCCN3CCc4ccc5c(C)noc5c4CC3)n2C)cn1	10.1016/j.bmcl.2007.12.042
	16078	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	16078.0	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	2424	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	4109	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	CHEMBL465	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	DB00470	1362	None	15	Human	Functional	pEC50	=	8.1	8.1	-1	7	Agonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayAgonist activity at recombinant human CB1 receptor expressed in CHO-K1 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay	Drug Central	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	None
	119570	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	119570.0	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3159	None	58	Human	Functional	pEC50	=	8.1	8.1	-2	11	NoneNone	Drug Central	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2105	3054	None	28	Human	Functional	pEC50	=	8.1	8.1	-1	25	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3054	None	28	Human	Functional	pEC50	=	8.1	8.1	-1	25	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3054	None	28	Human	Functional	pEC50	=	8.1	8.1	-1	25	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3054	None	28	Human	Functional	pEC50	=	8.1	8.1	-1	25	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3054	None	28	Human	Functional	pEC50	=	8.1	8.1	-1	25	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	30699	220190	None	0	Human	Functional	pIC50	=	8.3	8.3	-1	14	NoneNone	Drug Central	423	7	2	8	0.5	CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O	None
	4223	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314.0	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3992	None	57	Rat	Functional	pIC50	=	8.2	8.2	-97	17	Inhibition of rat dopamine D3 receptorInhibition of rat dopamine D3 receptor	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	4223	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	6918314.0	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	7427	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	CHEMBL439849	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	DB06684	3992	None	57	Human	Functional	pIC50	=	8.2	8.2	-97	17	NoneNone	Drug Central	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	None
	100	3805	None	44	Human	Functional	pIC50	=	8.1	8.1	-4	38	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3805	None	44	Human	Functional	pIC50	=	8.1	8.1	-4	38	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3805	None	44	Human	Functional	pIC50	=	8.1	8.1	-4	38	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3805	None	44	Human	Functional	pIC50	=	8.1	8.1	-4	38	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3805	None	44	Human	Functional	pIC50	=	8.1	8.1	-4	38	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	242	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795.0	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	470	None	70	Rat	Functional	pIC50	=	8.1	8.1	-4	33	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	11154555	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	11154555.0	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	800	None	50	Rat	Functional	pIC50	=	8.1	8.1	-1	10	NoneNone	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	10263487	3069	None	0	Human	Functional	pIC50	=	6.7	6.7	19	2	UnclassifiedUnclassified	Guide to Pharmacology	235	3	1	4	1.8	CCCN1C[C@H](OC[C@@H]1C)c1ccc(nc1)N	22470105
	7683	3069	None	0	Human	Functional	pIC50	=	6.7	6.7	19	2	UnclassifiedUnclassified	Guide to Pharmacology	235	3	1	4	1.8	CCCN1C[C@H](OC[C@@H]1C)c1ccc(nc1)N	22470105
	4223	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	6918314	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	6918314.0	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	7427	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	CHEMBL439849	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484
	DB06684	3992	None	57	Human	Functional	pIC50	=	7.2	7.2	-97	17	UnclassifiedUnclassified	Guide to Pharmacology	441	7	2	5	4.0	N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2	15341484

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	681	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	681.0	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	1465	None	47	Human	Binding	pAC50	=	9.4	9.4	-8	38	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	2407	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227.0	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	None	50	Human	Binding	pAC50	=	8.0	8.0	-5	7	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	1222	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396.0	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	None	37	Human	Binding	pAC50	=	7	7.0	-4	32	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Binding	pAC50	=	7	7.0	-1	55	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Binding	pAC50	=	7	7.0	-1	55	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Binding	pAC50	=	7	7.0	-1	55	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Binding	pAC50	=	7	7.0	-1	55	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Binding	pAC50	=	7	7.0	-1	55	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1802	2533	None	17	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	1	0	3	4.3	Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F	10.1038/s41467-023-40064-9
	3342	2533	None	17	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	1	0	3	4.3	Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F	10.1038/s41467-023-40064-9
	4192	2533	None	17	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	1	0	3	4.3	Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F	10.1038/s41467-023-40064-9
	CHEMBL655	2533	None	17	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	1	0	3	4.3	Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F	10.1038/s41467-023-40064-9
	DB00683	2533	None	17	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	1	0	3	4.3	Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F	10.1038/s41467-023-40064-9
	4499	59795	None	61	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59795	None	61	Human	Binding	pAC50	=	5	5.0	-	2	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	4417	55578	None	40	Human	Binding	pAC50	=	5.0	5.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1439099	55578	None	40	Human	Binding	pAC50	=	5.0	5.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL1620794	55578	None	40	Human	Binding	pAC50	=	5.0	5.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
	25151352	140693	None	56	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140693	None	56	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	57383420	109986	None	0	Human	Binding	pAC50	=	5.0	5.0	-	0	Antagonist activity at ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assayAntagonist activity at ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assay	ChEMBL	424	3	1	3	4.0	CN1C(=O)c2ccccc2[S@+]([O-])c2ccc(C(=O)NCc3ccc(Cl)cc3)cc21	10.1021/jm500126s
	CHEMBL3234540	109986	None	0	Human	Binding	pAC50	=	5.0	5.0	-	0	Antagonist activity at ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assayAntagonist activity at ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assay	ChEMBL	424	3	1	3	4.0	CN1C(=O)c2ccccc2[S@+]([O-])c2ccc(C(=O)NCc3ccc(Cl)cc3)cc21	10.1021/jm500126s
	2406	100458	None	56	Human	Binding	pAC50	=	5.0	5.0	-16	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	CHEMBL290106	100458	None	56	Human	Binding	pAC50	=	5.0	5.0	-16	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	2805	161984	None	27	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161984	None	27	Human	Binding	pAC50	=	6.0	6.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Binding	pAC50	=	7.0	7.0	-9	35	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	3952	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5353646	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5353646.0	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5443	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5702063	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5702063.0	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL1331786	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL420	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	DB00629	1888	None	32	Human	Binding	pAC50	=	5.0	5.0	-	12	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	4021	100534	None	72	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	CHEMBL290916	100534	None	72	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
	135398735	137055	None	20	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	136262914	137055	None	20	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL374478	137055	None	20	Human	Binding	pAC50	=	5.0	5.0	-	0	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	2107	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747.0	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	9216	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL251940	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB01608	3055	None	44	Human	Binding	pAC50	=	8.0	8.0	-	1	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	133	2496	None	39	Human	Binding	pAC50	=	8.0	8.0	-8	42	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2496	None	39	Human	Binding	pAC50	=	8.0	8.0	-8	42	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2496	None	39	Human	Binding	pAC50	=	8.0	8.0	-8	42	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2496	None	39	Human	Binding	pAC50	=	8.0	8.0	-8	42	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2496	None	39	Human	Binding	pAC50	=	8.0	8.0	-8	42	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Binding	pAC50	=	7.9	7.9	-26	67	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Binding	pAC50	=	7.9	7.9	-3	85	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2435	3590	None	59	Human	Binding	pAC50	=	7.0	7.0	-8	48	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	None	59	Human	Binding	pAC50	=	7.0	7.0	-8	48	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	None	59	Human	Binding	pAC50	=	7.0	7.0	-8	48	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	None	59	Human	Binding	pAC50	=	7.0	7.0	-8	48	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	None	59	Human	Binding	pAC50	=	7.0	7.0	-8	48	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	1577	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	2537	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5355	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	5501	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	643497	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	688272	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	688272.0	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	958	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	960	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL196677	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL26	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	CHEMBL267044	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB00391	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	DB16021	3703	None	66	Human	Binding	pAC50	=	7.0	7.0	-1	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Binding	pAC50	=	7.0	7.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Binding	pAC50	=	7.0	7.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Binding	pAC50	=	7.0	7.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Binding	pAC50	=	7.0	7.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Binding	pAC50	=	6.0	6.0	-	8	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Binding	pAC50	=	6.0	6.0	-	8	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Binding	pAC50	=	6.0	6.0	-	8	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Binding	pAC50	=	6.0	6.0	-	8	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Binding	pAC50	=	6.0	6.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Binding	pAC50	=	6.0	6.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Binding	pAC50	=	6.0	6.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Binding	pAC50	=	6.0	6.0	-3235	20	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3561	19084	None	29	Human	Binding	pAC50	=	5.9	5.9	-1	11	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1289	19084	None	29	Human	Binding	pAC50	=	5.9	5.9	-1	11	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
	22530	56146	None	40	Human	Binding	pAC50	=	5.9	5.9	-	3	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56146	None	40	Human	Binding	pAC50	=	5.9	5.9	-	3	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56146	None	40	Human	Binding	pAC50	=	5.9	5.9	-	3	Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9

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Ligand source activities (1 row/activity)