Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1218	3589	30	None	177	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	3589	30	None	177	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	3589	30	None	177	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	86764103	132411	13	None	-2	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL3697578	132411	13	None	-2	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	11938	2396	7	None	-69	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2396	7	None	-69	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2396	7	None	-69	4	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assayAgonist activity at mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	681	1453	72	None	1	15	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	940	1453	72	None	1	15	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	947	1453	72	None	1	15	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	CHEMBL59	1453	72	None	1	15	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	DB00988	1453	72	None	1	15	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	75202022	170786	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	170786	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	11681599	75144	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	75144	0	None	-	0	Human	10.3	pKi	=	10.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	11623343	140817	1	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	140817	1	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11493746	141298	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL383451	141298	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	11595240	140163	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	140163	0	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	11558055	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11558055	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	73123	1	None	-	0	Human	8.8	pKi	=	8.8	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	11522339	75223	1	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	CHEMBL203689	75223	1	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	11500677	140823	1	None	-	0	Human	6.0	pKi	=	6.0	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL381946	140823	1	None	-	0	Human	6.0	pKi	=	6.0	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	11573806	75387	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	75387	0	None	-	0	Human	7.9	pKi	=	7.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	5249952	73379	7	None	-	0	Human	7.0	pKi	=	7.0	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	CHEMBL201584	73379	7	None	-	0	Human	7.0	pKi	=	7.0	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	4350931	169289	44	None	-	1	Human	7.9	pKi	=	7.9	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL441618	169289	44	None	-	1	Human	7.9	pKi	=	7.9	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	4350931	169289	44	None	-	1	Human	7.9	pKi	=	7.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	CHEMBL441618	169289	44	None	-	1	Human	7.9	pKi	=	7.9	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	42626289	148055	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL393492	148055	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response	ChEMBL	379	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1	10.1016/j.bmc.2007.06.002
	11566745	74665	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	74665	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	74665	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	16090814	81552	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	81552	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	11716449	141190	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	141190	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	5249956	73366	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	73366	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	11573628	74670	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	CHEMBL203047	74670	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	11637457	73058	1	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	CHEMBL201093	73058	1	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	9992499	73357	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	CHEMBL201483	73357	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	11716438	140857	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	CHEMBL382010	140857	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	44436300	148812	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL394110	148812	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.06.002
	11558247	75393	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	75393	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	75201901	166401	19	None	-	4	Human	8.3	pKi	=	8.3	Functional	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	166401	19	None	-	4	Human	8.3	pKi	=	8.3	Functional	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	11536995	139530	1	None	-	0	Human	7.3	pKi	=	7.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL379662	139530	1	None	-	0	Human	7.3	pKi	=	7.3	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	11718008	75262	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL203734	75262	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	44408818	140140	1	None	-	0	Human	8.1	pKi	=	8.1	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	CHEMBL380330	140140	1	None	-	0	Human	8.1	pKi	=	8.1	Functional	Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	16090821	81804	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	CHEMBL216439	81804	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	122324	205	22	None	-128	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	6077	205	22	None	-128	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	CHEMBL86931	205	22	None	-128	4	Human	6.6	pEC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3158	56237	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-	20	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1353	1898	93	None	-54	86	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-54	86	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-54	86	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-54	86	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-54	86	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	1613	2333	53	None	-6	45	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-6	45	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-6	45	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-6	45	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-6	45	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-26	66	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-26	66	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-26	66	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-26	66	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	191	402	98	None	-	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2284	3160	33	None	-	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-	29	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	1427	2000	54	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human DRD5 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	85090335	181090	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	CHEMBL4760355	181090	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	168295528	193007	0	None	-4	20	Human	5.0	pEC50	=	5.0	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193007	0	None	-4	20	Human	5.0	pEC50	=	5.0	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193007	0	None	-4	20	Human	5.0	pEC50	=	5.0	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	85090318	179421	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740497	179421	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	168290235	192944	0	None	-16	20	Human	4.6	pEC50	=	4.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192944	0	None	-16	20	Human	4.6	pEC50	=	4.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192944	0	None	-16	20	Human	4.6	pEC50	=	4.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	85090319	180586	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4754602	180586	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090328	181011	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4759339	181011	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090333	181277	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4762375	181277	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090332	180695	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4755709	180695	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	2030130	20947	16	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL1311333	20947	16	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090338	180737	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4756163	180737	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	168294767	192995	0	None	-4	20	Human	4.5	pEC50	=	4.5	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-4	20	Human	4.5	pEC50	=	4.5	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-4	20	Human	4.5	pEC50	=	4.5	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	164612037	185353	0	None	-4	20	Human	5.4	pEC50	=	5.4	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185353	0	None	-4	20	Human	5.4	pEC50	=	5.4	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	85090324	180668	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4755481	180668	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090325	179725	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4744261	179725	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090321	182789	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4790909	182789	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090329	182658	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4789255	182658	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	11938	2396	7	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2396	7	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2396	7	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Positive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D5 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	85090334	180601	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4754761	180601	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090323	181898	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4779641	181898	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	85090326	182749	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4790277	182749	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	85090331	181429	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4764398	181429	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	85090322	179435	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740678	179435	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090339	182281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	CHEMBL4784143	182281	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	85090320	182539	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4787728	182539	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	4901726	180775	9	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4756486	180775	9	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	76284418	182294	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4784295	182294	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	136326241	179404	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4740312	179404	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090330	181049	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4759814	181049	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	85090337	183257	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796761	183257	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	76284419	183224	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796389	183224	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	3036864	202731	19	None	-3	28	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL1256645	202731	19	None	-3	28	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL1814790	202731	19	None	-3	28	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	CHEMBL62	202731	19	None	-3	28	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
	3036864	202731	19	None	-3	28	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1256645	202731	19	None	-3	28	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1814790	202731	19	None	-3	28	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL62	202731	19	None	-3	28	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	5018	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	943	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	946	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	CHEMBL13668	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
	5018	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	943	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	946	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	CHEMBL13668	3523	13	None	-2	10	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
	3036864	202731	19	None	-3	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1256645	202731	19	None	-3	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1814790	202731	19	None	-3	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL62	202731	19	None	-3	28	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	10907460	9796	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL113956	9796	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	11071079	110566	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL325516	110566	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	496	9	0	3	6.0	O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	11730467	10996	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL117537	10996	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	11113605	10475	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	CHEMBL116735	10475	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	480	9	0	2	5.8	O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
	10918307	9953	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	514	5	1	7	2.6	CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O	10.1021/jm010878g
	CHEMBL114825	9953	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	514	5	1	7	2.6	CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O	10.1021/jm010878g
	11059058	10059	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	CHEMBL115444	10059	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	11005810	10434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL116463	10434	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	10885636	110989	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	CHEMBL326263	110989	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
	164612037	185353	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	CHEMBL4860528	185353	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
	168290235	192944	0	None	-16	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5201074	192944	0	None	-16	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222491	192944	0	None	-16	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
	168294767	192995	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5207281	192995	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222802	192995	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	168295528	193007	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5206565	193007	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	CHEMBL5222872	193007	0	None	-4	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D5 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
	11681599	75144	0	None	12	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	75144	0	None	12	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	3036864	202731	19	None	-3	28	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1256645	202731	19	None	-3	28	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL1814790	202731	19	None	-3	28	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	CHEMBL62	202731	19	None	-3	28	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
	16665071	93372	0	None	7	4	Human	9.6	pKi	=	9.6	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL245764	93372	0	None	7	4	Human	9.6	pKi	=	9.6	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
	3036864	202731	19	None	-3	28	Human	9.5	pKi	=	9.5	Binding	Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL1256645	202731	19	None	-3	28	Human	9.5	pKi	=	9.5	Binding	Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL1814790	202731	19	None	-3	28	Human	9.5	pKi	=	9.5	Binding	Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	CHEMBL62	202731	19	None	-3	28	Human	9.5	pKi	=	9.5	Binding	Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
	11465618	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	44439943	93337	0	None	1	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL245570	93337	0	None	1	4	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
	3036864	202731	19	None	-3	28	Human	9.3	pKi	=	9.3	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1256645	202731	19	None	-3	28	Human	9.3	pKi	=	9.3	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL1814790	202731	19	None	-3	28	Human	9.3	pKi	=	9.3	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	CHEMBL62	202731	19	None	-3	28	Human	9.3	pKi	=	9.3	Binding	Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
	6852376	91570	13	None	3	5	Human	9.3	pKi	=	9.3	Binding	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL1467585	91570	13	None	3	5	Human	9.3	pKi	=	9.3	Binding	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL24077	91570	13	None	3	5	Human	9.3	pKi	=	9.3	Binding	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	CHEMBL503958	91570	13	None	3	5	Human	9.3	pKi	=	9.3	Binding	Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
	11778580	66097	1	None	5	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
	CHEMBL184050	66097	1	None	5	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
	16090814	81552	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	81552	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	11393666	192962	0	None	-1	19	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192962	0	None	-1	19	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192962	0	None	-1	19	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D5 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	11595240	140163	0	None	-3	4	Human	9.0	pKi	=	9.0	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	140163	0	None	-3	4	Human	9.0	pKi	=	9.0	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	11488247	200616	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL599487	200616	0	None	-1	4	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
	46231784	201315	0	None	-2	4	Human	8.9	pKi	=	8.9	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL604314	201315	0	None	-2	4	Human	8.9	pKi	=	8.9	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
	11558055	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	73123	1	None	-2	6	Human	8.8	pKi	=	8.8	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	11623343	140817	1	None	2	4	Human	8.8	pKi	=	8.8	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	140817	1	None	2	4	Human	8.8	pKi	=	8.8	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	1243	3591	34	None	-3	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2021.128047
	944	3591	34	None	-3	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2021.128047
	CHEMBL324017	3591	34	None	-3	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2021.128047
	10402378	66095	0	None	19	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
	CHEMBL184049	66095	0	None	19	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
	122205438	137375	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
	CHEMBL3753266	137375	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
	46216855	200355	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL597900	200355	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	46231925	201355	0	None	-5	4	Human	8.0	pKi	=	8	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	CHEMBL604525	201355	0	None	-5	4	Human	8.0	pKi	=	8	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	45379370	7491	0	None	2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
	CHEMBL1087301	7491	0	None	2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
	11269330	201470	0	None	-34	4	Human	8.0	pKi	=	8.0	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL605127	201470	0	None	-34	4	Human	8.0	pKi	=	8.0	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	135398745	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	47	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	CHEMBL715	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	DB00334	2893	112	None	-26	66	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
	10947658	28671	0	None	-912	16	Human	6.0	pKi	=	6	Binding	Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28671	0	None	-912	16	Human	6.0	pKi	=	6	Binding	Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	135398737	955	93	None	-89	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	38	955	93	None	-89	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	722	955	93	None	-89	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	CHEMBL42	955	93	None	-89	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	DB00363	955	93	None	-89	92	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
	2389	3306	118	None	-239	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	5073	3306	118	None	-239	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	96	3306	118	None	-239	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	CHEMBL85	3306	118	None	-239	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	DB00734	3306	118	None	-239	68	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
	155552185	174037	0	None	-1819	16	Human	6.0	pKi	=	6	Binding	Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	CHEMBL4544086	174037	0	None	-1819	16	Human	6.0	pKi	=	6	Binding	Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
	154724609	176575	1	None	-11	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4514800	176575	1	None	-11	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4597637	176575	1	None	-11	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	145969667	164941	0	None	-41	6	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225278	164941	0	None	-41	6	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	681	1453	72	None	-67	39	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	940	1453	72	None	-67	39	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	947	1453	72	None	-67	39	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	CHEMBL59	1453	72	None	-67	39	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	DB00988	1453	72	None	-67	39	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	21527771	70127	1	None	-40	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	70127	1	None	-40	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	44415593	80218	0	None	-104	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	CHEMBL213834	80218	0	None	-104	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
	242	469	124	None	-380	52	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	34	469	124	None	-380	52	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	60795	469	124	None	-380	52	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL1112	469	124	None	-380	52	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	DB01238	469	124	None	-380	52	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	154704368	176447	1	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4569006	176447	1	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4596571	176447	1	None	-229	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
	126720252	164651	0	None	-38	12	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	CHEMBL4216870	164651	0	None	-38	12	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	11566745	74665	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	74665	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	74665	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	154704418	176563	1	None	-2	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4546749	176563	1	None	-2	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	CHEMBL4597533	176563	1	None	-2	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
	11408135	124162	0	None	-245	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	443	7	1	4	4.5	COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2	10.1021/jm049031l
	CHEMBL363406	124162	0	None	-245	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	443	7	1	4	4.5	COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2	10.1021/jm049031l
	5249956	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
	CHEMBL201525	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
	5249956	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
	CHEMBL201525	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
	5249956	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	73366	1	None	-2	6	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	56594534	70571	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
	CHEMBL1949728	70571	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
	56597938	3909	3	None	-1380	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	7651	3909	3	None	-1380	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	CHEMBL2165126	3909	3	None	-1380	9	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	164618319	184569	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	CHEMBL4848838	184569	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	340	2	1	4	2.1	CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	122181333	121848	0	None	-7762	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	CHEMBL3590084	121848	0	None	-7762	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
	154725276	176266	1	None	-40	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4456964	176266	1	None	-40	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595147	176266	1	None	-40	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
	11335419	67070	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
	CHEMBL187367	67070	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
	21533446	70126	0	None	-30	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	70126	0	None	-30	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	44436302	90605	0	None	-23	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	429	7	0	6	2.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL238917	90605	0	None	-23	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	429	7	0	6	2.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmcl.2021.128028
	44436302	90605	0	None	-23	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	429	7	0	6	2.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL238917	90605	0	None	-23	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	429	7	0	6	2.4	COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1	10.1016/j.bmc.2007.06.002
	681	1453	72	None	-67	39	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	940	1453	72	None	-67	39	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	947	1453	72	None	-67	39	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	CHEMBL59	1453	72	None	-67	39	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	DB00988	1453	72	None	-67	39	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm401384w
	11573806	75387	0	None	-6	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	75387	0	None	-6	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	11151831	13088	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1190453	13088	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL540868	13088	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	154706513	176562	1	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4440698	176562	1	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	CHEMBL4597532	176562	1	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
	53324045	57041	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644980	57041	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	3038495	705	37	None	-831	19	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	7625	705	37	None	-831	19	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	CHEMBL25236	705	37	None	-831	19	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
	1242	3586	27	None	-6	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2011.08.033
	935	3586	27	None	-6	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2011.08.033
	CHEMBL286080	3586	27	None	-6	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2011.08.033
	33630	178933	99	None	-5	28	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL47050	178933	99	None	-5	28	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	164609730	185075	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	CHEMBL4856060	185075	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	398	2	1	5	3.5	CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	11154178	200203	0	None	-64	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
	CHEMBL596824	200203	0	None	-64	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
	122191607	123696	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
	CHEMBL3622099	123696	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
	137654675	158610	0	None	-3388	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	CHEMBL4092441	158610	0	None	-3388	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
	11739113	13065	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	297	4	1	2	3.7	C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1190331	13065	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	297	4	1	2	3.7	C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL540613	13065	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	297	4	1	2	3.7	C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	57391216	70139	0	None	-66	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940416	70139	0	None	-66	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	11716449	141190	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	141190	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	164609539	184375	0	None	-2	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	CHEMBL4845850	184375	0	None	-2	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	428	2	0	5	3.3	O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	145988180	165207	0	None	-12	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4229178	165207	0	None	-12	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	164585473	184538	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to D5 receptor (unknown origin)Binding affinity to D5 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	CHEMBL4848380	184538	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to D5 receptor (unknown origin)Binding affinity to D5 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
	44209480	70141	0	None	-1318	11	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940418	70141	0	None	-1318	11	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	11637457	73058	1	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
	CHEMBL201093	73058	1	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
	228	444	28	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	33	444	28	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	6005	444	28	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	CHEMBL53	444	28	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	DB00714	444	28	None	-3	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
	3246443	37656	2	None	-2	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	CHEMBL1457510	37656	2	None	-2	6	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
	137636066	156209	0	None	-9549	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4064742	156209	0	None	-9549	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	11439436	12762	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1188091	12762	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL535151	12762	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	46227284	199692	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
	CHEMBL593394	199692	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
	90644071	112015	0	None	-8	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289655	112015	0	None	-8	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
	45379377	7425	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
	CHEMBL1086790	7425	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
	44591134	176176	0	None	-125	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	CHEMBL459373	176176	0	None	-125	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
	72164182	92121	0	None	-25	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
	CHEMBL2420777	92121	0	None	-25	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
	154703647	176341	1	None	-28	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4450429	176341	1	None	-28	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	CHEMBL4595728	176341	1	None	-28	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
	6603820	95745	19	None	-1	13	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
	CHEMBL25856	95745	19	None	-1	13	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
	10200496	83564	0	None	-30	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
	CHEMBL2204343	83564	0	None	-30	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
	242	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	34	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	60795	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	CHEMBL1112	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	DB01238	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
	242	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	34	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	60795	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	CHEMBL1112	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	DB01238	469	124	None	-380	52	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
	163198500	186374	3	None	3	2	Human	5.8	pKi	=	5.8	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
	CHEMBL4875858	186374	3	None	3	2	Human	5.8	pKi	=	5.8	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	371	1	0	3	3.2	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	10.1016/j.bmcl.2021.128008
	137655795	158558	0	None	-6309	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4091933	158558	0	None	-6309	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
	137660046	159319	0	None	-22387	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
	CHEMBL4100183	159319	0	None	-22387	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
	11324023	12779	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1188254	12779	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL535823	12779	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	299	4	1	2	3.9	CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	11416811	12793	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1188384	12793	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL536271	12793	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	11438636	13087	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	285	3	0	2	3.5	COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1	10.1021/jm040889k
	CHEMBL1190452	13087	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	285	3	0	2	3.5	COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1	10.1021/jm040889k
	CHEMBL540867	13087	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	285	3	0	2	3.5	COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1	10.1021/jm040889k
	11818686	13865	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2	10.1021/jm040889k
	CHEMBL1196231	13865	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2	10.1021/jm040889k
	CHEMBL556194	13865	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2	10.1021/jm040889k
	85658088	164979	0	None	-5	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225830	164979	0	None	-5	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	44436300	148812	0	None	-64	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL394110	148812	0	None	-64	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2021.128028
	44436300	148812	0	None	-64	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL394110	148812	0	None	-64	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	399	6	0	5	2.4	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1	10.1016/j.bmc.2007.06.002
	17755866	142859	1	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
	CHEMBL389356	142859	1	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
	180	400	56	None	-112	40	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	200	400	56	None	-112	40	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	2160	400	56	None	-112	40	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	CHEMBL629	400	56	None	-112	40	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	DB00321	400	56	None	-112	40	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
	44436305	154380	0	None	-23	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	430	6	0	5	4.0	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL398813	154380	0	None	-23	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	430	6	0	5	4.0	O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	11464115	68605	0	None	-89	3	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	413	6	1	3	4.5	O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1	10.1021/jm049031l
	CHEMBL191815	68605	0	None	-89	3	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	413	6	1	3	4.5	O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1	10.1021/jm049031l
	2726	916	68	None	-47	73	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	621	916	68	None	-47	73	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	83	916	68	None	-47	73	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	CHEMBL71	916	68	None	-47	73	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	DB00477	916	68	None	-47	73	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
	154705520	176236	1	None	-114	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4452683	176236	1	None	-114	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4594959	176236	1	None	-114	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	76314268	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115577	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139633	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	72164180	92116	0	None	-38	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	326	3	0	3	4.4	Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl	10.1016/j.bmcl.2013.07.033
	CHEMBL2420772	92116	0	None	-38	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	326	3	0	3	4.4	Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl	10.1016/j.bmcl.2013.07.033
	11134444	90604	0	None	-17	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	467	6	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL238916	90604	0	None	-17	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	467	6	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2021.128028
	11134444	90604	0	None	-17	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	467	6	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL238916	90604	0	None	-17	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	467	6	0	5	3.5	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	57401819	70131	0	None	-229	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940408	70131	0	None	-229	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
	76314268	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115577	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139633	106407	0	None	-1230	4	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
	46227325	200104	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
	CHEMBL596179	200104	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
	11358377	202316	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
	CHEMBL610449	202316	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
	154726793	176209	1	None	-61	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4590966	176209	1	None	-61	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4594692	176209	1	None	-61	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	46227317	200140	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	CHEMBL596448	200140	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
	44436306	97171	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	417	6	0	3	4.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL268371	97171	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	417	6	0	3	4.2	O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2007.06.002
	137645830	157828	0	None	-478	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
	CHEMBL4083727	157828	0	None	-478	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
	11449266	13919	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1	10.1021/jm040889k
	CHEMBL1196658	13919	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1	10.1021/jm040889k
	CHEMBL557781	13919	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	257	2	1	2	2.9	COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1	10.1021/jm040889k
	11449669	13920	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	271	3	1	2	3.1	CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1196659	13920	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	271	3	1	2	3.1	CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL557782	13920	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	271	3	1	2	3.1	CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	11210215	13971	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1197038	13971	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL559164	13971	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	311	5	0	2	4.0	C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	76336022	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115581	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139316	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	11775107	166192	0	None	-588	3	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	443	7	1	4	4.5	COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2	10.1021/jm049031l
	CHEMBL426629	166192	0	None	-588	3	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain	ChEMBL	443	7	1	4	4.5	COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2	10.1021/jm049031l
	76336022	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3115581	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	CHEMBL3139316	106352	0	None	-512	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	386	6	1	5	3.3	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2	10.1021/jm401384w
	135398737	955	93	None	-89	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	38	955	93	None	-89	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	722	955	93	None	-89	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	CHEMBL42	955	93	None	-89	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	DB00363	955	93	None	-89	92	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
	75306277	109227	0	None	-99	23	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	109227	0	None	-99	23	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	90644062	112007	0	None	-104	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289647	112007	0	None	-104	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	154727843	176409	1	None	-17	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4448853	176409	1	None	-17	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4596221	176409	1	None	-17	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	107930	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	3304	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	CHEMBL298406	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	DB12273	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
	107930	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	3304	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	CHEMBL298406	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	DB12273	1517	26	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
	46231927	201513	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL605354	201513	0	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	1243	3591	34	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human D5 receptorBinding affinity to human D5 receptor	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2020.127053
	944	3591	34	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human D5 receptorBinding affinity to human D5 receptor	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2020.127053
	CHEMBL324017	3591	34	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human D5 receptorBinding affinity to human D5 receptor	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1016/j.bmcl.2020.127053
	45379369	7490	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
	CHEMBL1087300	7490	0	None	1	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
	46231926	200556	0	None	-12	4	Human	8.6	pKi	=	8.6	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	CHEMBL599135	200556	0	None	-12	4	Human	8.6	pKi	=	8.6	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
	3036864	202731	19	None	-3	28	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL1256645	202731	19	None	-3	28	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL1814790	202731	19	None	-3	28	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	CHEMBL62	202731	19	None	-3	28	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
	11416809	12772	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL1188198	12772	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	CHEMBL535602	12772	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL	313	5	0	2	4.2	CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1	10.1021/jm040889k
	23653176	91174	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	383	6	0	3	3.8	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL239917	91174	0	None	4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	383	6	0	3	3.8	O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2007.06.002
	763625	92119	7	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	276	3	0	3	3.2	Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1	10.1016/j.bmcl.2013.07.033
	CHEMBL2420775	92119	7	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay	ChEMBL	276	3	0	3	3.2	Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1	10.1016/j.bmcl.2013.07.033
	1212	1649	50	None	-28	66	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	204	1649	50	None	-28	66	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	3372	1649	50	None	-28	66	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	CHEMBL726	1649	50	None	-28	66	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	DB00623	1649	50	None	-28	66	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
	164615845	185166	0	None	-2	6	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
	CHEMBL4857492	185166	0	None	-2	6	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
	164623060	186146	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	325	1	0	3	4.0	CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	CHEMBL4872572	186146	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)	ChEMBL	325	1	0	3	4.0	CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2	10.1016/j.bmcl.2021.128008
	122177644	121186	0	None	-17378	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	CHEMBL3577345	121186	0	None	-17378	6	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
	154725234	176268	1	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4585289	176268	1	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	CHEMBL4595149	176268	1	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
	90644062	112007	0	None	-104	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289647	112007	0	None	-104	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
	46231924	200555	0	None	-5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	CHEMBL599134	200555	0	None	-5	4	Human	7.7	pKi	=	7.7	Binding	Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
	154705128	176267	1	None	-151	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4454872	176267	1	None	-151	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	CHEMBL4595148	176267	1	None	-151	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
	156020558	178022	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	CHEMBL4647167	178022	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
	11558247	75393	0	None	-6	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	75393	0	None	-6	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	145969667	164941	0	None	-41	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	CHEMBL4225278	164941	0	None	-41	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
	44436301	90603	0	None	-6	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	433	6	0	5	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	CHEMBL238915	90603	0	None	-6	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human D5RBinding affinity to human D5R	ChEMBL	433	6	0	5	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2021.128028
	44436301	90603	0	None	-6	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	433	6	0	5	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2007.06.002
	CHEMBL238915	90603	0	None	-6	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293	ChEMBL	433	6	0	5	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2007.06.002
	135398737	955	93	None	-89	92	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	38	955	93	None	-89	92	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	722	955	93	None	-89	92	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	CHEMBL42	955	93	None	-89	92	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	DB00363	955	93	None	-89	92	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
	44209472	70143	2	None	-1318	11	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	CHEMBL1940420	70143	2	None	-1318	11	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
	181743	178548	5	None	-1202	22	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	178548	5	None	-1202	22	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	122177641	121183	0	None	-38018	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	CHEMBL3577342	121183	0	None	-38018	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
	161665	172561	35	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
	CHEMBL448891	172561	35	None	-3	5	Human	6.6	pKi	=	6.6	Binding

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Ligand source activities (1 row/activity)