Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
1218 | 3616 | None | 23 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 295 | 4 | ChEMBL | 289 | 1 | 3 | 3 | 3.0 | Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 | 10.1021/acsmedchemlett.9b00050 | |||
938 | 3616 | None | 23 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 295 | 4 | ChEMBL | 289 | 1 | 3 | 3 | 3.0 | Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 | 10.1021/acsmedchemlett.9b00050 | |||
CHEMBL353335 | 3616 | None | 23 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 295 | 4 | ChEMBL | 289 | 1 | 3 | 3 | 3.0 | Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 | 10.1021/acsmedchemlett.9b00050 | |||
86764103 | 132505 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 389 | 5 | 1 | 6 | 3.1 | Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C | 10.1021/acsmedchemlett.9b00050 | |||
CHEMBL3697578 | 132505 | None | 15 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -2 | 2 | ChEMBL | 389 | 5 | 1 | 6 | 3.1 | Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C | 10.1021/acsmedchemlett.9b00050 | |||
11938 | 2412 | None | 8 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -69 | 4 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
146192952 | 2412 | None | 8 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -69 | 4 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
CHEMBL4468760 | 2412 | None | 8 | Mouse | Functional | pEC50 | = | 5.8 | 5.8 | -69 | 4 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
681 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
681.0 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
940 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
947 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
CHEMBL59 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
DB00988 | 1465 | None | 47 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/acsmedchemlett.9b00050 | |||
75202022 | 170913 | None | 5 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 363 | 3 | 1 | 6 | 3.3 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C | 10.1021/acsmedchemlett.9b00050 | |||
CHEMBL4453318 | 170913 | None | 5 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -1 | 2 | ChEMBL | 363 | 3 | 1 | 6 | 3.3 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C | 10.1021/acsmedchemlett.9b00050 | |||
11681599 | 75199 | None | 0 | Human | Functional | pKi | = | 10.3 | 10.3 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
CHEMBL203637 | 75199 | None | 0 | Human | Functional | pKi | = | 10.3 | 10.3 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
11623343 | 140929 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL381936 | 140929 | None | 0 | Human | Functional | pKi | = | 9.3 | 9.3 | - | 0 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
11493746 | 141410 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 335 | 0 | 1 | 2 | 4.3 | CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
CHEMBL383451 | 141410 | None | 0 | Human | Functional | pKi | = | 8.9 | 8.9 | - | 0 | ChEMBL | 335 | 0 | 1 | 2 | 4.3 | CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
11595240 | 140275 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 | 10.1021/jm051237e | |||
CHEMBL380464 | 140275 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 | 10.1021/jm051237e | |||
11558055 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL201170 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
11558055 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL201170 | 73177 | None | 0 | Human | Functional | pKi | = | 8.8 | 8.8 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
11522339 | 75278 | None | 0 | Human | Functional | pKi | = | 8.0 | 8.0 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2c(O)cccc2CC1 | 10.1021/jm051237e | |||
CHEMBL203689 | 75278 | None | 0 | Human | Functional | pKi | = | 8.0 | 8.0 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2c(O)cccc2CC1 | 10.1021/jm051237e | |||
11500677 | 140935 | None | 0 | Human | Functional | pKi | = | 6.0 | 6.0 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
CHEMBL381946 | 140935 | None | 0 | Human | Functional | pKi | = | 6.0 | 6.0 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
11573806 | 75443 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 | 10.1021/jm051237e | |||
CHEMBL204065 | 75443 | None | 0 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 | 10.1021/jm051237e | |||
5249952 | 73433 | None | 5 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 304 | 1 | 1 | 1 | 4.4 | CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 | 10.1021/jm050846j | |||
CHEMBL201584 | 73433 | None | 5 | Human | Functional | pKi | = | 7.0 | 7.0 | - | 0 | ChEMBL | 304 | 1 | 1 | 1 | 4.4 | CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 | 10.1021/jm050846j | |||
4350931 | 169416 | None | 30 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
CHEMBL441618 | 169416 | None | 30 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
4350931 | 169416 | None | 30 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm051237e | |||
CHEMBL441618 | 169416 | None | 30 | Human | Functional | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm051237e | |||
42626289 | 148167 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 379 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL393492 | 148167 | None | 0 | Human | Functional | pKi | = | 6.9 | 6.9 | - | 0 | ChEMBL | 379 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
11566745 | 74720 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL1202298 | 74720 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL203029 | 74720 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
16090814 | 81612 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
CHEMBL216258 | 81612 | None | 0 | Human | Functional | pKi | = | 8.6 | 8.6 | - | 0 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
11716449 | 141302 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | |||
CHEMBL382850 | 141302 | None | 0 | Human | Functional | pKi | = | 7.7 | 7.7 | - | 0 | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | |||
5249956 | 73420 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | |||
CHEMBL201525 | 73420 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | |||
11573628 | 74725 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL203047 | 74725 | None | 0 | Human | Functional | pKi | = | 8.5 | 8.5 | - | 0 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 | 10.1021/jm051237e | |||
11637457 | 73112 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | |||
CHEMBL201093 | 73112 | None | 0 | Human | Functional | pKi | = | 7.5 | 7.5 | - | 0 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | |||
9992499 | 73411 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | |||
CHEMBL201483 | 73411 | None | 0 | Human | Functional | pKi | = | 6.5 | 6.5 | - | 0 | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | |||
11716438 | 140969 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm051237e | |||
CHEMBL382010 | 140969 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm051237e | |||
44436300 | 148924 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL394110 | 148924 | None | 0 | Human | Functional | pKi | = | 6.4 | 6.4 | - | 0 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
11558247 | 75449 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 282 | 0 | 2 | 3 | 2.6 | CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL204098 | 75449 | None | 0 | Human | Functional | pKi | = | 7.4 | 7.4 | - | 0 | ChEMBL | 282 | 0 | 2 | 3 | 2.6 | CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 | 10.1021/jm051237e | |||
75201901 | 166520 | None | 21 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 4 | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.8b01622 | |||
CHEMBL4277264 | 166520 | None | 21 | Human | Functional | pKi | = | 8.3 | 8.3 | - | 4 | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.8b01622 | |||
11536995 | 139642 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1cccc2c1Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
CHEMBL379662 | 139642 | None | 0 | Human | Functional | pKi | = | 7.3 | 7.3 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1cccc2c1Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
11718008 | 75317 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 349 | 1 | 0 | 2 | 4.6 | COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
CHEMBL203734 | 75317 | None | 0 | Human | Functional | pKi | = | 7.2 | 7.2 | - | 0 | ChEMBL | 349 | 1 | 0 | 2 | 4.6 | COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 | 10.1021/jm051237e | |||
44408818 | 140252 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1021/jm051237e | |||
CHEMBL380330 | 140252 | None | 0 | Human | Functional | pKi | = | 8.1 | 8.1 | - | 0 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1021/jm051237e | |||
16090821 | 81864 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | |||
CHEMBL216439 | 81864 | None | 0 | Human | Functional | pKi | = | 7.1 | 7.1 | - | 0 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | |||
122324 | 205 | None | 17 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -128 | 4 | Guide to Pharmacology | 271 | 2 | 3 | 4 | 2.4 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 | 16318870 | |||
6077 | 205 | None | 17 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -128 | 4 | Guide to Pharmacology | 271 | 2 | 3 | 4 | 2.4 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 | 16318870 | |||
CHEMBL86931 | 205 | None | 17 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -128 | 4 | Guide to Pharmacology | 271 | 2 | 3 | 4 | 2.4 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 | 16318870 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
3158 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
3158.0 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1628227 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
DB01142 | 56283 | None | 21 | Human | Binding | pAC50 | = | 5.8 | 5.8 | - | 20 | ChEMBL | 279 | 3 | 0 | 2 | 4.0 | CN(C)CCC=C1c2ccccc2COc2ccccc21 | 10.1038/s41467-023-40064-9 | |||
1353 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
3559 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
86 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pAC50 | = | 6.7 | 6.7 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
1613 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
205 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
3964 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
3964.0 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
CHEMBL831 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
DB00408 | 2348 | None | 42 | Human | Binding | pAC50 | = | 6.6 | 6.6 | -5 | 44 | ChEMBL | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | 10.1038/s41467-023-40064-9 | |||
135398745 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
47 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
DB00334 | 2914 | None | 65 | Human | Binding | pAC50 | = | 6.4 | 6.4 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1038/s41467-023-40064-9 | |||
191 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
201 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
2170 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
2170.0 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
CHEMBL1113 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
DB00543 | 403 | None | 60 | Human | Binding | pAC50 | = | 6.3 | 6.3 | - | 28 | ChEMBL | 313 | 0 | 1 | 4 | 3.4 | Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 | 10.1038/s41467-023-40064-9 | |||
2284 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
4926 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
7281 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL564 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
DB00420 | 3182 | None | 26 | Human | Binding | pAC50 | = | 5.2 | 5.2 | - | 28 | ChEMBL | 284 | 4 | 0 | 3 | 4.2 | CN(CCCN1c2ccccc2Sc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
1427 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 26 | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
357 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 26 | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
3696 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 26 | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
CHEMBL11 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 26 | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
DB00458 | 2013 | None | 42 | Human | Binding | pAC50 | = | 5.1 | 5.1 | - | 26 | ChEMBL | 280 | 4 | 0 | 2 | 3.9 | CN(CCCN1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
85090335 | 181220 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 359 | 3 | 0 | 5 | 3.4 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4760355 | 181220 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 359 | 3 | 0 | 5 | 3.4 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 | 10.1016/j.bmcl.2020.127696 | |||
168295528 | 193140 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5206565 | 193140 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222872 | 193140 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
85090318 | 179551 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 413 | 3 | 0 | 5 | 4.7 | Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4740497 | 179551 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 413 | 3 | 0 | 5 | 4.7 | Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
168290235 | 193077 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5201074 | 193077 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222491 | 193077 | None | 0 | Human | Binding | pEC50 | = | 4.6 | 4.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
85090319 | 180716 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 401 | 3 | 0 | 6 | 3.9 | COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4754602 | 180716 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 401 | 3 | 0 | 6 | 3.9 | COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090328 | 181141 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 385 | 2 | 0 | 5 | 4.2 | Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4759339 | 181141 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 385 | 2 | 0 | 5 | 4.2 | Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090333 | 181407 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 399 | 2 | 0 | 5 | 4.6 | Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4762375 | 181407 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 399 | 2 | 0 | 5 | 4.6 | Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090332 | 180825 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 3 | 0 | 6 | 4.6 | COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4755709 | 180825 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 435 | 3 | 0 | 6 | 4.6 | COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
2030130 | 20986 | None | 17 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 385 | 2 | 0 | 5 | 4.3 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL1311333 | 20986 | None | 17 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 385 | 2 | 0 | 5 | 4.3 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
85090338 | 180867 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 389 | 4 | 0 | 6 | 3.4 | COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4756163 | 180867 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 389 | 4 | 0 | 6 | 3.4 | COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
168294767 | 193128 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5207281 | 193128 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222802 | 193128 | None | 0 | Human | Binding | pEC50 | = | 4.5 | 4.5 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
164612037 | 185483 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | -4 | 20 | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL4860528 | 185483 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | -4 | 20 | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | |||
85090324 | 180798 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 405 | 2 | 0 | 5 | 4.5 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4755481 | 180798 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 405 | 2 | 0 | 5 | 4.5 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
85090325 | 179855 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 405 | 2 | 0 | 5 | 4.5 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4744261 | 179855 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 405 | 2 | 0 | 5 | 4.5 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
85090321 | 182919 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 373 | 3 | 0 | 5 | 3.7 | Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4790909 | 182919 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 373 | 3 | 0 | 5 | 3.7 | Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090329 | 182788 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 419 | 2 | 0 | 5 | 4.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4789255 | 182788 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 419 | 2 | 0 | 5 | 4.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
11938 | 2412 | None | 8 | Mouse | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
146192952 | 2412 | None | 8 | Mouse | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
CHEMBL4468760 | 2412 | None | 8 | Mouse | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 443 | 4 | 1 | 4 | 4.4 | C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl | 10.1021/acs.jmedchem.1c01887 | |||
85090334 | 180731 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 399 | 3 | 0 | 5 | 4.4 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4754761 | 180731 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 399 | 3 | 0 | 5 | 4.4 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
85090323 | 182028 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.1 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4779641 | 182028 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.1 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090326 | 182879 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 423 | 4 | 0 | 6 | 4.1 | COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4790277 | 182879 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 423 | 4 | 0 | 6 | 4.1 | COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
85090331 | 181559 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 449 | 3 | 0 | 6 | 4.9 | COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4764398 | 181559 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 449 | 3 | 0 | 6 | 4.9 | COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
85090322 | 179565 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 415 | 3 | 0 | 6 | 4.3 | COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4740678 | 179565 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 415 | 3 | 0 | 6 | 4.3 | COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 | 10.1016/j.bmcl.2020.127696 | |||
85090339 | 182411 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.1 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4784143 | 182411 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 393 | 3 | 0 | 5 | 4.1 | CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 | 10.1016/j.bmcl.2020.127696 | |||
85090320 | 182669 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 433 | 3 | 0 | 5 | 5.0 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4787728 | 182669 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 433 | 3 | 0 | 5 | 5.0 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
4901726 | 180905 | None | 6 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 419 | 2 | 0 | 5 | 4.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4756486 | 180905 | None | 6 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 419 | 2 | 0 | 5 | 4.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
76284418 | 182424 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 371 | 2 | 0 | 5 | 3.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4784295 | 182424 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 371 | 2 | 0 | 5 | 3.9 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
136326241 | 179534 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 295 | 1 | 1 | 4 | 2.4 | Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4740312 | 179534 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 295 | 1 | 1 | 4 | 2.4 | Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
85090330 | 181179 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 463 | 4 | 0 | 6 | 5.0 | COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4759814 | 181179 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 463 | 4 | 0 | 6 | 5.0 | COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl | 10.1016/j.bmcl.2020.127696 | |||
85090337 | 183387 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 433 | 3 | 0 | 5 | 5.0 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4796761 | 183387 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 433 | 3 | 0 | 5 | 5.0 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
76284419 | 183354 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 343 | 2 | 0 | 5 | 3.1 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
CHEMBL4796389 | 183354 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 343 | 2 | 0 | 5 | 3.1 | Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 | 10.1016/j.bmcl.2020.127696 | |||
3036864 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmc.2013.03.016 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmc.2013.03.016 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmc.2013.03.016 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmc.2013.03.016 | |||
3036864 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
5018 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.11.014 | |||
943 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.11.014 | |||
946 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.11.014 | |||
CHEMBL13668 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.11.014 | |||
5018 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.03.006 | |||
943 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.03.006 | |||
946 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.03.006 | |||
CHEMBL13668 | 3549 | None | 8 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -2 | 9 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 10.1016/j.bmc.2016.03.006 | |||
3036864 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pIC50 | = | 9.0 | 9.0 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
10907460 | 9830 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL113956 | 9830 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 521 | 11 | 1 | 3 | 5.8 | CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
11071079 | 110656 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL325516 | 110656 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 496 | 9 | 0 | 3 | 6.0 | O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
11730467 | 11032 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL117537 | 11032 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 476 | 10 | 0 | 2 | 6.0 | O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
11113605 | 10510 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
CHEMBL116735 | 10510 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 480 | 9 | 0 | 2 | 5.8 | O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1021/jm010878g | |||
10918307 | 9987 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 514 | 5 | 1 | 7 | 2.6 | CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O | 10.1021/jm010878g | |||
CHEMBL114825 | 9987 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 514 | 5 | 1 | 7 | 2.6 | CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O | 10.1021/jm010878g | |||
11059058 | 10093 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
CHEMBL115444 | 10093 | None | 0 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 429 | 3 | 1 | 7 | 4.1 | O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 | 10.1021/jm010878g | |||
11005810 | 10469 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL116463 | 10469 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 517 | 10 | 1 | 4 | 6.2 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
10885636 | 111079 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
CHEMBL326263 | 111079 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 503 | 9 | 0 | 4 | 5.7 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | 10.1021/jm010878g | |||
164612037 | 185483 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL4860528 | 185483 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 326 | 8 | 4 | 4 | 1.8 | CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C | 10.1021/acs.jmedchem.1c00692 | |||
168290235 | 193077 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5201074 | 193077 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222491 | 193077 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -16 | 20 | ChEMBL | 315 | 6 | 4 | 3 | 1.1 | C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 | 10.1021/acs.jmedchem.1c00692 | |||
168294767 | 193128 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5207281 | 193128 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222802 | 193128 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 313 | 8 | 4 | 5 | 0.9 | CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
168295528 | 193140 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5206565 | 193140 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
CHEMBL5222872 | 193140 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | -4 | 20 | ChEMBL | 333 | 6 | 4 | 5 | 0.9 | N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 | 10.1021/acs.jmedchem.1c00692 | |||
11681599 | 75199 | None | 0 | Human | Binding | pKi | = | 10.2 | 10.2 | 12 | 6 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
CHEMBL203637 | 75199 | None | 0 | Human | Binding | pKi | = | 10.2 | 10.2 | 12 | 6 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | 10.1021/jm051237e | |||
3036864 | 205211 | None | 16 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pKi | = | 9.8 | 9.8 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.ejmech.2013.01.044 | |||
16665071 | 93454 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 7 | 4 | ChEMBL | 334 | 1 | 0 | 3 | 3.8 | COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL245764 | 93454 | None | 0 | Human | Binding | pKi | = | 9.6 | 9.6 | 7 | 4 | ChEMBL | 334 | 1 | 0 | 3 | 3.8 | COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 | 10.1016/j.bmcl.2006.11.093 | |||
3036864 | 205211 | None | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2020.127305 | |||
11465618 | 102453 | None | 23 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 19 | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL3039528 | 102453 | None | 23 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 19 | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL5191141 | 102453 | None | 23 | Human | Binding | pKi | = | 9.4 | 9.4 | -1 | 19 | ChEMBL | 354 | 2 | 0 | 2 | 4.9 | CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C | 10.1016/j.bmcl.2022.128879 | |||
44439943 | 93419 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 4 | ChEMBL | 306 | 0 | 2 | 2 | 3.5 | CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL245570 | 93419 | None | 0 | Human | Binding | pKi | = | 9.4 | 9.4 | 1 | 4 | ChEMBL | 306 | 0 | 2 | 2 | 3.5 | CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
3036864 | 205211 | None | 16 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pKi | = | 9.3 | 9.3 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm8007618 | |||
6852376 | 91633 | None | 9 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL1467585 | 91633 | None | 9 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL24077 | 91633 | None | 9 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL503958 | 91633 | None | 9 | Human | Binding | pKi | = | 9.3 | 9.3 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
11778580 | 66148 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 5 | 5 | ChEMBL | 283 | 0 | 1 | 3 | 2.9 | CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm049720x | |||
CHEMBL184050 | 66148 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 5 | 5 | ChEMBL | 283 | 0 | 1 | 3 | 2.9 | CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm049720x | |||
16090814 | 81612 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 5 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
CHEMBL216258 | 81612 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 5 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
11393666 | 193095 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL5201983 | 193095 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
CHEMBL5222597 | 193095 | None | 0 | Human | Binding | pKi | = | 9.2 | 9.2 | -1 | 19 | ChEMBL | 340 | 2 | 1 | 2 | 4.6 | CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 | 10.1016/j.bmcl.2022.128879 | |||
11595240 | 140275 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -3 | 4 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 | 10.1021/jm051237e | |||
CHEMBL380464 | 140275 | None | 0 | Human | Binding | pKi | = | 9.0 | 9.0 | -3 | 4 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 | 10.1021/jm051237e | |||
11488247 | 203095 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 470 | 5 | 1 | 4 | 4.5 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL599487 | 203095 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 4 | ChEMBL | 470 | 5 | 1 | 4 | 4.5 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
46231784 | 203795 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 4 | ChEMBL | 329 | 0 | 2 | 3 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL604314 | 203795 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | -2 | 4 | ChEMBL | 329 | 0 | 2 | 3 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1039/C5MD00258C | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1016/j.bmc.2009.08.028 | |||
11558055 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL1204122 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL201170 | 73177 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 6 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm050846j | |||
11623343 | 140929 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 4 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL381936 | 140929 | None | 0 | Human | Binding | pKi | = | 8.8 | 8.8 | 2 | 4 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 | 10.1021/jm051237e | |||
1243 | 3618 | None | 30 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2021.128047 | |||
944 | 3618 | None | 30 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2021.128047 | |||
CHEMBL324017 | 3618 | None | 30 | Human | Binding | pKi | = | 8.8 | 8.8 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2021.128047 | |||
10402378 | 66146 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 19 | 5 | ChEMBL | 297 | 1 | 0 | 3 | 3.2 | COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 | 10.1021/jm049720x | |||
CHEMBL184049 | 66146 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | 19 | 5 | ChEMBL | 297 | 1 | 0 | 3 | 3.2 | COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 | 10.1021/jm049720x | |||
122205438 | 137487 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 5 | ChEMBL | 307 | 0 | 0 | 2 | 4.5 | CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 | 10.1039/C5MD00258C | |||
CHEMBL3753266 | 137487 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 5 | ChEMBL | 307 | 0 | 0 | 2 | 4.5 | CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 | 10.1039/C5MD00258C | |||
46216855 | 202834 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 395 | 1 | 1 | 3 | 5.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL597900 | 202834 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 395 | 1 | 1 | 3 | 5.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
1243 | 3618 | None | 30 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.6019/CHEMBL5442175 | |||
944 | 3618 | None | 30 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.6019/CHEMBL5442175 | |||
CHEMBL324017 | 3618 | None | 30 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.6019/CHEMBL5442175 | |||
46231925 | 203835 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -5 | 4 | ChEMBL | 384 | 3 | 1 | 4 | 4.4 | CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL604525 | 203835 | None | 0 | Human | Binding | pKi | = | 8 | 8.0 | -5 | 4 | ChEMBL | 384 | 3 | 1 | 4 | 4.4 | CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
45379370 | 7525 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 2 | 5 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 | 10.1021/jm901291r | |||
CHEMBL1087301 | 7525 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 2 | 5 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 | 10.1021/jm901291r | |||
11269330 | 203950 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -34 | 4 | ChEMBL | 390 | 1 | 1 | 3 | 5.0 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL605127 | 203950 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -34 | 4 | ChEMBL | 390 | 1 | 1 | 3 | 5.0 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
135398745 | 2914 | None | 65 | Human | Binding | pKi | = | 7 | 7.0 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pKi | = | 7 | 7.0 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
47 | 2914 | None | 65 | Human | Binding | pKi | = | 7 | 7.0 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pKi | = | 7 | 7.0 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
DB00334 | 2914 | None | 65 | Human | Binding | pKi | = | 7 | 7.0 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C2MD00311B | |||
10947658 | 28710 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -912 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
CHEMBL137781 | 28710 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -912 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 6 | 6.0 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 6 | 6.0 | -234 | 67 | ChEMBL | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 10.1039/C2MD00311B | |||
155552185 | 174165 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1819 | 16 | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | |||
CHEMBL4544086 | 174165 | None | 0 | Human | Binding | pKi | = | 6 | 6.0 | -1819 | 16 | ChEMBL | 491 | 10 | 2 | 5 | 4.3 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | |||
154724609 | 176704 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | -11 | 5 | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4514800 | 176704 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | -11 | 5 | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597637 | 176704 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | -11 | 5 | ChEMBL | 440 | 10 | 0 | 6 | 4.8 | COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
45376872 | 70100 | None | 20 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 446 | 7 | 3 | 6 | 3.4 | CCOC(=O)c1cc2cc(-c3cc(C(=O)NCc4ccc(C(=O)O)cc4)nn3C)ccc2[nH]1 | 10.6019/CHEMBL4507281 | |||
CHEMBL1939876 | 70100 | None | 20 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 446 | 7 | 3 | 6 | 3.4 | CCOC(=O)c1cc2cc(-c3cc(C(=O)NCc4ccc(C(=O)O)cc4)nn3C)ccc2[nH]1 | 10.6019/CHEMBL4507281 | |||
56850410 | 70102 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 374 | 5 | 3 | 4 | 3.2 | Cn1nc(C(=O)NCc2ccc(C(=O)O)cc2)cc1-c1ccc2[nH]ccc2c1 | 10.6019/CHEMBL4507281 | |||
CHEMBL1939880 | 70102 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | - | 1 | ChEMBL | 374 | 5 | 3 | 4 | 3.2 | Cn1nc(C(=O)NCc2ccc(C(=O)O)cc2)cc1-c1ccc2[nH]ccc2c1 | 10.6019/CHEMBL4507281 | |||
72901200 | 119841 | None | 26 | Human | Binding | pKi | = | 5 | 5.0 | -6918 | 33 | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | 10.6019/CHEMBL4507309 | |||
CHEMBL3480577 | 119841 | None | 26 | Human | Binding | pKi | = | 5 | 5.0 | -6918 | 33 | ChEMBL | 322 | 7 | 2 | 4 | 3.8 | Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1 | 10.6019/CHEMBL4507309 | |||
CHEMBL4522773 | 216443 | None | 0 | Human | Binding | pKi | = | 5 | 5.0 | -15 | 3 | ChEMBL | None | None | None | CC1=C(C#N)[C@@H](c2ccc3[nH]nc(C)c3c2)C(C#N)=C(c2ccc(Cl)cc2)N1 | 10.6019/CHEMBL4507263 | |||||
145969667 | 165060 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4225278 | 165060 | None | 0 | Human | Binding | pKi | = | 7 | 7.0 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
681 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
681.0 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
940 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
947 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
CHEMBL59 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
DB00988 | 1465 | None | 47 | Human | Binding | pKi | = | 6.0 | 6.0 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
21527771 | 70180 | None | 1 | Human | Binding | pKi | = | 7.0 | 7.0 | -40 | 10 | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
CHEMBL1940404 | 70180 | None | 1 | Human | Binding | pKi | = | 7.0 | 7.0 | -40 | 10 | ChEMBL | 363 | 6 | 1 | 3 | 4.2 | OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
172463952 | 196538 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -91 | 8 | ChEMBL | 418 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
CHEMBL5426242 | 196538 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -91 | 8 | ChEMBL | 418 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
172463952 | 196538 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -91 | 8 | ChEMBL | 418 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
CHEMBL5426242 | 196538 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -91 | 8 | ChEMBL | 418 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2ccc(=O)[nH]c2c1)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
42611190 | 3156 | None | 14 | Human | Binding | pKi | = | 6.0 | 6.0 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
5802 | 3156 | None | 14 | Human | Binding | pKi | = | 6.0 | 6.0 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pKi | = | 6.0 | 6.0 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442175 | |||
44415593 | 80278 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -104 | 6 | ChEMBL | 495 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL213834 | 80278 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -104 | 6 | ChEMBL | 495 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 6.0 | 6.0 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | nan | |||
154704368 | 176576 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -229 | 6 | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4569006 | 176576 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -229 | 6 | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4596571 | 176576 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -229 | 6 | ChEMBL | 421 | 11 | 2 | 2 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
126720252 | 164770 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -38 | 13 | ChEMBL | 697 | 15 | 2 | 6 | 9.2 | NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 | 10.1021/acs.jmedchem.8b00168 | |||
CHEMBL4216870 | 164770 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -38 | 13 | ChEMBL | 697 | 15 | 2 | 6 | 9.2 | NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 | 10.1021/acs.jmedchem.8b00168 | |||
130 | 3500 | None | 32 | Human | Binding | pKi | = | 6.0 | 6.0 | -295 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
3378093 | 3500 | None | 32 | Human | Binding | pKi | = | 6.0 | 6.0 | -295 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
CHEMBL281350 | 3500 | None | 32 | Human | Binding | pKi | = | 6.0 | 6.0 | -295 | 21 | ChEMBL | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 10.6019/CHEMBL5442175 | |||
11566745 | 74720 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 4 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL1202298 | 74720 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 4 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
CHEMBL203029 | 74720 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 4 | ChEMBL | 283 | 0 | 2 | 3 | 2.7 | CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 | 10.1021/jm050846j | |||
154704418 | 176692 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 5 | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4546749 | 176692 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 5 | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597533 | 176692 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 5 | ChEMBL | 458 | 12 | 1 | 6 | 4.8 | Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 | 10.1021/acs.jmedchem.9b01835 | |||
11408135 | 124255 | None | 0 | Rat | Binding | pKi | = | 5.0 | 5.0 | -245 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | |||
CHEMBL363406 | 124255 | None | 0 | Rat | Binding | pKi | = | 5.0 | 5.0 | -245 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | |||
5249956 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1039/C5MD00258C | |||
CHEMBL201525 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1039/C5MD00258C | |||
5249956 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL201525 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
5249956 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | |||
CHEMBL201525 | 73420 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -2 | 6 | ChEMBL | 251 | 0 | 0 | 1 | 3.3 | CN1CCc2ccccc2Cc2ccccc2CC1 | 10.1021/jm050846j | |||
56594534 | 70624 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO | 10.1021/jm200676f | |||
CHEMBL1949728 | 70624 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -1 | 5 | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO | 10.1021/jm200676f | |||
56597938 | 3940 | None | 4 | Human | Binding | pKi | = | 6.0 | 6.0 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
7651 | 3940 | None | 4 | Human | Binding | pKi | = | 6.0 | 6.0 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL2165126 | 3940 | None | 4 | Human | Binding | pKi | = | 6.0 | 6.0 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
164618319 | 184699 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 3 | ChEMBL | 340 | 2 | 1 | 4 | 2.1 | CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4848838 | 184699 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | 1 | 3 | ChEMBL | 340 | 2 | 1 | 4 | 2.1 | CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
122181333 | 121940 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -7762 | 6 | ChEMBL | 366 | 8 | 1 | 2 | 3.8 | CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
CHEMBL3590084 | 121940 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -7762 | 6 | ChEMBL | 366 | 8 | 1 | 2 | 3.8 | CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
154725276 | 176395 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 6 | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4456964 | 176395 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 6 | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595147 | 176395 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -40 | 6 | ChEMBL | 478 | 12 | 1 | 3 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
11335419 | 67121 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -11 | 6 | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/jm049720x | |||
CHEMBL187367 | 67121 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -11 | 6 | ChEMBL | 295 | 7 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 | 10.1021/jm049720x | |||
21533446 | 70179 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -30 | 10 | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
CHEMBL1940403 | 70179 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -30 | 10 | ChEMBL | 379 | 6 | 1 | 3 | 4.9 | OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
44436302 | 90668 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -23 | 4 | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | |||
CHEMBL238917 | 90668 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -23 | 4 | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmcl.2021.128028 | |||
44436302 | 90668 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -23 | 4 | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL238917 | 90668 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -23 | 4 | ChEMBL | 429 | 7 | 0 | 6 | 2.4 | COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
681 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
681.0 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
940 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
947 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
CHEMBL59 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
DB00988 | 1465 | None | 47 | Human | Binding | pKi | = | 5.9 | 5.9 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm401384w | |||
11573806 | 75443 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 4 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 | 10.1021/jm051237e | |||
CHEMBL204065 | 75443 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 4 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 | 10.1021/jm051237e | |||
11151831 | 13125 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1190453 | 13125 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL540868 | 13125 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
154706513 | 176691 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -18 | 5 | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4440698 | 176691 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -18 | 5 | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597532 | 176691 | None | 1 | Human | Binding | pKi | = | 5.9 | 5.9 | -18 | 5 | ChEMBL | 480 | 12 | 0 | 6 | 5.6 | COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 | 10.1021/acs.jmedchem.9b01835 | |||
53324045 | 57087 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 16 | ChEMBL | 487 | 7 | 1 | 2 | 7.3 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL1644980 | 57087 | None | 0 | Human | Binding | pKi | = | 6.9 | 6.9 | -3 | 16 | ChEMBL | 487 | 7 | 1 | 2 | 7.3 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
3038495 | 708 | None | 33 | Human | Binding | pKi | = | 5.9 | 5.9 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | |||
7625 | 708 | None | 33 | Human | Binding | pKi | = | 5.9 | 5.9 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL25236 | 708 | None | 33 | Human | Binding | pKi | = | 5.9 | 5.9 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/acs.jmedchem.9b01835 | |||
1242 | 3613 | None | 17 | Human | Binding | pKi | = | 6.9 | 6.9 | -6 | 17 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 10.1016/j.bmc.2011.08.033 | |||
935 | 3613 | None | 17 | Human | Binding | pKi | = | 6.9 | 6.9 | -6 | 17 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 10.1016/j.bmc.2011.08.033 | |||
CHEMBL286080 | 3613 | None | 17 | Human | Binding | pKi | = | 6.9 | 6.9 | -6 | 17 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 10.1016/j.bmc.2011.08.033 | |||
487 | 3634 | None | 20 | Human | Binding | pKi | = | 5.9 | 5.9 | -3235 | 28 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442175 | |||
60602 | 3634 | None | 20 | Human | Binding | pKi | = | 5.9 | 5.9 | -3235 | 28 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442175 | |||
CHEMBL405355 | 3634 | None | 20 | Human | Binding | pKi | = | 5.9 | 5.9 | -3235 | 28 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442175 | |||
DB09239 | 3634 | None | 20 | Human | Binding | pKi | = | 5.9 | 5.9 | -3235 | 28 | ChEMBL | 609 | 10 | 1 | 8 | 6.0 | COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C | 10.6019/CHEMBL5442175 | |||
33630 | 179063 | None | 62 | Human | Binding | pKi | = | 6.9 | 6.9 | -5 | 27 | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL47050 | 179063 | None | 62 | Human | Binding | pKi | = | 6.9 | 6.9 | -5 | 27 | ChEMBL | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
164609730 | 185205 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 3 | ChEMBL | 398 | 2 | 1 | 5 | 3.5 | CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4856060 | 185205 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1 | 3 | ChEMBL | 398 | 2 | 1 | 5 | 3.5 | CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
11154178 | 202682 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -64 | 3 | ChEMBL | 412 | 4 | 1 | 3 | 4.6 | CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL596824 | 202682 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -64 | 3 | ChEMBL | 412 | 4 | 1 | 3 | 4.6 | CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 | 10.1016/j.bmcl.2009.12.100 | |||
122191607 | 123789 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1778 | 5 | ChEMBL | 468 | 9 | 1 | 3 | 5.0 | CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1021/acsmedchemlett.5b00131 | |||
CHEMBL3622099 | 123789 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -1778 | 5 | ChEMBL | 468 | 9 | 1 | 3 | 5.0 | CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 | 10.1021/acsmedchemlett.5b00131 | |||
137654675 | 158726 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -3388 | 6 | ChEMBL | 433 | 7 | 2 | 7 | 2.9 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4092441 | 158726 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | -3388 | 6 | ChEMBL | 433 | 7 | 2 | 7 | 2.9 | O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 | 10.1021/acs.jmedchem.7b00363 | |||
11739113 | 13102 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1190331 | 13102 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL540613 | 13102 | None | 0 | Human | Binding | pKi | = | 4.9 | 4.9 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
57391216 | 70192 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -66 | 8 | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940416 | 70192 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -66 | 8 | ChEMBL | 332 | 6 | 0 | 5 | 2.9 | Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
11716449 | 141302 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 2 | 4 | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | |||
CHEMBL382850 | 141302 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | 2 | 4 | ChEMBL | 304 | 1 | 1 | 1 | 4.2 | CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm050846j | |||
164609539 | 184505 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 428 | 2 | 0 | 5 | 3.3 | O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4845850 | 184505 | None | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -2 | 3 | ChEMBL | 428 | 2 | 0 | 5 | 3.3 | O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
145988180 | 165326 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 6 | ChEMBL | 303 | 10 | 1 | 2 | 5.3 | CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4229178 | 165326 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -12 | 6 | ChEMBL | 303 | 10 | 1 | 2 | 5.3 | CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
164585473 | 184668 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -2 | 5 | ChEMBL | 503 | 5 | 1 | 2 | 7.2 | O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.1c00164 | |||
CHEMBL4848380 | 184668 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -2 | 5 | ChEMBL | 503 | 5 | 1 | 2 | 7.2 | O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.1c00164 | |||
44209480 | 70194 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1318 | 11 | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940418 | 70194 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -1318 | 11 | ChEMBL | 313 | 6 | 0 | 3 | 3.4 | Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
11637457 | 73112 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1039/C5MD00258C | |||
CHEMBL201093 | 73112 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1039/C5MD00258C | |||
228 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
33 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
6005 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
6005.0 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
CHEMBL53 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
DB00714 | 445 | None | 20 | Human | Binding | pKi | = | 7.8 | 7.8 | -3 | 24 | ChEMBL | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 10.1016/j.bmcl.2020.127053 | |||
3246443 | 37697 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -2 | 6 | ChEMBL | 325 | 1 | 1 | 5 | 2.8 | COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL1457510 | 37697 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -2 | 6 | ChEMBL | 325 | 1 | 1 | 5 | 2.8 | COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | |||
137636066 | 156324 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -9549 | 6 | ChEMBL | 480 | 7 | 3 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4064742 | 156324 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -9549 | 6 | ChEMBL | 480 | 7 | 3 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
11439436 | 12798 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188091 | 12798 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL535151 | 12798 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
46227284 | 202171 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 1 | 2 | ChEMBL | 281 | 1 | 0 | 2 | 3.5 | COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL593394 | 202171 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 1 | 2 | ChEMBL | 281 | 1 | 0 | 2 | 3.5 | COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 | 10.1016/j.bmc.2009.08.028 | |||
90644071 | 112105 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -8 | 5 | ChEMBL | 368 | 5 | 0 | 3 | 5.2 | Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289655 | 112105 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -8 | 5 | ChEMBL | 368 | 5 | 0 | 3 | 5.2 | Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
45379377 | 7459 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 1 | 3 | ChEMBL | 274 | 0 | 1 | 1 | 3.7 | c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 | 10.1021/jm901291r | |||
CHEMBL1086790 | 7459 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | 1 | 3 | ChEMBL | 274 | 0 | 1 | 1 | 3.7 | c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 | 10.1021/jm901291r | |||
44591134 | 176304 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 6 | ChEMBL | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL459373 | 176304 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 6 | ChEMBL | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
72164182 | 92184 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -25 | 5 | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl | 10.1016/j.bmcl.2013.07.033 | |||
CHEMBL2420777 | 92184 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -25 | 5 | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl | 10.1016/j.bmcl.2013.07.033 | |||
150860015 | 195040 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -7 | 17 | ChEMBL | 440 | 10 | 2 | 6 | 4.9 | CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2ccc(Cl)c3cccnc23)cn1 | 10.1021/acs.jmedchem.2c01769 | |||
CHEMBL5395401 | 195040 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -7 | 17 | ChEMBL | 440 | 10 | 2 | 6 | 4.9 | CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2ccc(Cl)c3cccnc23)cn1 | 10.1021/acs.jmedchem.2c01769 | |||
172450959 | 195711 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -51 | 8 | ChEMBL | 420 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
CHEMBL5409419 | 195711 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -51 | 8 | ChEMBL | 420 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
154703647 | 176470 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -28 | 5 | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4450429 | 176470 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -28 | 5 | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595728 | 176470 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -28 | 5 | ChEMBL | 468 | 12 | 0 | 6 | 5.6 | CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
6603820 | 95827 | None | 16 | Rat | Binding | pKi | = | 7.8 | 7.8 | -1 | 13 | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL25856 | 95827 | None | 16 | Rat | Binding | pKi | = | 7.8 | 7.8 | -1 | 13 | ChEMBL | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | 10.1016/j.bmc.2009.08.028 | |||
10200496 | 83626 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -30 | 5 | ChEMBL | 391 | 6 | 1 | 3 | 3.6 | O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm1013693 | |||
CHEMBL2204343 | 83626 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -30 | 5 | ChEMBL | 391 | 6 | 1 | 3 | 3.6 | O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm1013693 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.08.037 | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1021/acs.jmedchem.7b00363 | |||
163198500 | 186504 | None | 3 | Human | Binding | pKi | = | 5.8 | 5.8 | 3 | 2 | ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4875858 | 186504 | None | 3 | Human | Binding | pKi | = | 5.8 | 5.8 | 3 | 2 | ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2021.128008 | |||
137655795 | 158674 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -6309 | 6 | ChEMBL | 453 | 7 | 2 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4091933 | 158674 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -6309 | 6 | ChEMBL | 453 | 7 | 2 | 7 | 3.0 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
137660046 | 159437 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -22387 | 6 | ChEMBL | 437 | 7 | 2 | 8 | 2.4 | O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4100183 | 159437 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -22387 | 6 | ChEMBL | 437 | 7 | 2 | 8 | 2.4 | O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 | 10.1021/acs.jmedchem.7b00363 | |||
11324023 | 12815 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188254 | 12815 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL535823 | 12815 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 299 | 4 | 1 | 2 | 3.9 | CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11416811 | 12829 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188384 | 12829 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL536271 | 12829 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11438636 | 13124 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1190452 | 13124 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL540867 | 13124 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
11818686 | 13902 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 | 10.1021/jm040889k | |||
CHEMBL1196231 | 13902 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 | 10.1021/jm040889k | |||
CHEMBL556194 | 13902 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 | 10.1021/jm040889k | |||
85658088 | 165098 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 6 | ChEMBL | 219 | 4 | 1 | 2 | 3.0 | CCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4225830 | 165098 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -5 | 6 | ChEMBL | 219 | 4 | 1 | 2 | 3.0 | CCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
172450959 | 195711 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -51 | 8 | ChEMBL | 420 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
CHEMBL5409419 | 195711 | None | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -51 | 8 | ChEMBL | 420 | 7 | 1 | 5 | 4.5 | COc1cccc2c3c(oc12)CN(CCCCOc1ccc2c(c1)NC(=O)CC2)CC3 | 10.1021/acs.jmedchem.3c00098 | |||
44436300 | 148924 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -64 | 4 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
CHEMBL394110 | 148924 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -64 | 4 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
44436300 | 148924 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -64 | 4 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL394110 | 148924 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -64 | 4 | ChEMBL | 399 | 6 | 0 | 5 | 2.4 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
17755866 | 142971 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 5 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm070388+ | |||
CHEMBL389356 | 142971 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -1 | 5 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 | 10.1021/jm070388+ | |||
180 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
200 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
2160 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
2160.0 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL629 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
DB00321 | 401 | None | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1016/j.bmcl.2008.09.012 | |||
44436305 | 154493 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -23 | 3 | ChEMBL | 430 | 6 | 0 | 5 | 4.0 | O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL398813 | 154493 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -23 | 3 | ChEMBL | 430 | 6 | 0 | 5 | 4.0 | O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
11464115 | 68656 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -89 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
CHEMBL191815 | 68656 | None | 0 | Rat | Binding | pKi | = | 5.8 | 5.8 | -89 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
2726 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
621 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
83 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | ChEMBL | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 10.1016/j.bmcl.2008.09.012 | |||
154705520 | 176365 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -114 | 6 | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4452683 | 176365 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -114 | 6 | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4594959 | 176365 | None | 1 | Human | Binding | pKi | = | 5.8 | 5.8 | -114 | 6 | ChEMBL | 448 | 11 | 1 | 3 | 5.6 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
76314268 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115577 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139633 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
72164180 | 92179 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -38 | 4 | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | |||
CHEMBL2420772 | 92179 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -38 | 4 | ChEMBL | 326 | 3 | 0 | 3 | 4.4 | Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl | 10.1016/j.bmcl.2013.07.033 | |||
11134444 | 90667 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -17 | 7 | ChEMBL | 467 | 6 | 0 | 5 | 3.5 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
CHEMBL238916 | 90667 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -17 | 7 | ChEMBL | 467 | 6 | 0 | 5 | 3.5 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
11134444 | 90667 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -17 | 7 | ChEMBL | 467 | 6 | 0 | 5 | 3.5 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL238916 | 90667 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -17 | 7 | ChEMBL | 467 | 6 | 0 | 5 | 3.5 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
57401819 | 70184 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -229 | 7 | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940408 | 70184 | None | 0 | Human | Binding | pKi | = | 5.8 | 5.8 | -229 | 7 | ChEMBL | 346 | 6 | 0 | 2 | 4.6 | Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
76314268 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115577 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139633 | 106490 | None | 0 | Human | Binding | pKi | = | 4.8 | 4.8 | -1230 | 4 | ChEMBL | 450 | 3 | 1 | 4 | 3.5 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
46227325 | 202583 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 1 | 2 | ChEMBL | 267 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2C1 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL596179 | 202583 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 1 | 2 | ChEMBL | 267 | 0 | 1 | 2 | 3.4 | CN1CCCc2cc(O)ccc2Cc2ccccc2C1 | 10.1016/j.bmc.2009.08.028 | |||
11358377 | 204796 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 295 | 0 | 0 | 3 | 3.5 | CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL610449 | 204796 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 295 | 0 | 0 | 3 | 3.5 | CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 | 10.1016/j.bmc.2009.08.028 | |||
129989 | 451 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -457 | 11 | ChEMBL | 463 | 9 | 1 | 5 | 4.5 | CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC | 10.6019/CHEMBL5442175 | |||
8584 | 451 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -457 | 11 | ChEMBL | 463 | 9 | 1 | 5 | 4.5 | CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC | 10.6019/CHEMBL5442175 | |||
CHEMBL43383 | 451 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -457 | 11 | ChEMBL | 463 | 9 | 1 | 5 | 4.5 | CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC | 10.6019/CHEMBL5442175 | |||
154726793 | 176338 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -61 | 5 | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4590966 | 176338 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -61 | 5 | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4594692 | 176338 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -61 | 5 | ChEMBL | 454 | 11 | 0 | 6 | 5.2 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
46227317 | 202619 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -1 | 5 | ChEMBL | 265 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL596448 | 202619 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -1 | 5 | ChEMBL | 265 | 1 | 0 | 2 | 3.4 | COc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | |||
44436306 | 97253 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | 1 | 3 | ChEMBL | 417 | 6 | 0 | 3 | 4.2 | O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL268371 | 97253 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | 1 | 3 | ChEMBL | 417 | 6 | 0 | 3 | 4.2 | O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
137645830 | 157944 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -478 | 6 | ChEMBL | 424 | 7 | 1 | 8 | 2.8 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4083727 | 157944 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -478 | 6 | ChEMBL | 424 | 7 | 1 | 8 | 2.8 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 | 10.1021/acs.jmedchem.7b00363 | |||
11449266 | 13956 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196658 | 13956 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL557781 | 13956 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 257 | 2 | 1 | 2 | 2.9 | COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 | 10.1021/jm040889k | |||
11449669 | 13957 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196659 | 13957 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL557782 | 13957 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11210215 | 14008 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1197038 | 14008 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL559164 | 14008 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 311 | 5 | 0 | 2 | 4.0 | C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
76336022 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115581 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139316 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
11775107 | 166311 | None | 0 | Rat | Binding | pKi | = | 5.7 | 5.7 | -588 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | |||
CHEMBL426629 | 166311 | None | 0 | Rat | Binding | pKi | = | 5.7 | 5.7 | -588 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | |||
76336022 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115581 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139316 | 106435 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -512 | 3 | ChEMBL | 386 | 6 | 1 | 5 | 3.3 | Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
9893924 | 4750 | None | 24 | Human | Binding | pKi | = | 5.7 | 5.7 | -81 | 22 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442175 | |||
CHEMBL103769 | 4750 | None | 24 | Human | Binding | pKi | = | 5.7 | 5.7 | -81 | 22 | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442175 | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1016/j.bmcl.2008.09.012 | |||
75306277 | 109310 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -99 | 23 | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
CHEMBL3217984 | 109310 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -99 | 23 | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
90644062 | 112097 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -104 | 5 | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289647 | 112097 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -104 | 5 | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
154727843 | 176538 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -17 | 5 | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4448853 | 176538 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -17 | 5 | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4596221 | 176538 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -17 | 5 | ChEMBL | 486 | 13 | 0 | 6 | 5.6 | CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
107930 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | |||
107930.0 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | |||
3304 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL298406 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | |||
DB12273 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.100 | |||
107930 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | |||
107930.0 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | |||
3304 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL298406 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | |||
DB12273 | 1529 | None | 25 | Human | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 10.1016/j.bmcl.2009.12.094 | |||
46231927 | 203993 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 432 | 3 | 1 | 4 | 5.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL605354 | 203993 | None | 0 | Human | Binding | pKi | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 432 | 3 | 1 | 4 | 5.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
1243 | 3618 | None | 30 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127053 | |||
944 | 3618 | None | 30 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127053 | |||
CHEMBL324017 | 3618 | None | 30 | Human | Binding | pKi | = | 8.6 | 8.6 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127053 | |||
45379369 | 7524 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | 1 | 5 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 | 10.1021/jm901291r | |||
CHEMBL1087300 | 7524 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | 1 | 5 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 | 10.1021/jm901291r | |||
46231926 | 203035 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -12 | 4 | ChEMBL | 446 | 4 | 1 | 4 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL599135 | 203035 | None | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | -12 | 4 | ChEMBL | 446 | 4 | 1 | 4 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
3036864 | 205211 | None | 16 | Human | Binding | pKi | = | 8.6 | 8.6 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pKi | = | 8.6 | 8.6 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pKi | = | 8.6 | 8.6 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pKi | = | 8.6 | 8.6 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
11416809 | 12808 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188198 | 12808 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL535602 | 12808 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 313 | 5 | 0 | 2 | 4.2 | CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
23653176 | 91237 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | 4 | 3 | ChEMBL | 383 | 6 | 0 | 3 | 3.8 | O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL239917 | 91237 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | 4 | 3 | ChEMBL | 383 | 6 | 0 | 3 | 3.8 | O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
763625 | 92182 | None | 4 | Human | Binding | pKi | = | 5.7 | 5.7 | -19 | 2 | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | |||
CHEMBL2420775 | 92182 | None | 4 | Human | Binding | pKi | = | 5.7 | 5.7 | -19 | 2 | ChEMBL | 276 | 3 | 0 | 3 | 3.2 | Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | |||
3038495 | 708 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
7625 | 708 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
CHEMBL25236 | 708 | None | 33 | Human | Binding | pKi | = | 5.7 | 5.7 | -1047 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.6019/CHEMBL5442175 | |||
1212 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
204 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
3372 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
3372.0 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL726 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
DB00623 | 1662 | None | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | ChEMBL | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 10.1016/j.bmcl.2008.09.012 | |||
164615845 | 185296 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -2 | 6 | ChEMBL | 389 | 2 | 1 | 4 | 3.7 | O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4857492 | 185296 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -2 | 6 | ChEMBL | 389 | 2 | 1 | 4 | 3.7 | O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 | 10.1016/j.bmcl.2021.128008 | |||
164623060 | 186276 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 325 | 1 | 0 | 3 | 4.0 | CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4872572 | 186276 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 325 | 1 | 0 | 3 | 4.0 | CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
122177644 | 121276 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -17378 | 6 | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | |||
CHEMBL3577345 | 121276 | None | 0 | Human | Binding | pKi | = | 4.7 | 4.7 | -17378 | 6 | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | |||
154725234 | 176397 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -3 | 5 | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4585289 | 176397 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -3 | 5 | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595149 | 176397 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -3 | 5 | ChEMBL | 472 | 12 | 0 | 6 | 5.2 | CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF | 10.1021/acs.jmedchem.9b01835 | |||
90644062 | 112097 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -104 | 5 | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289647 | 112097 | None | 0 | Human | Binding | pKi | = | 5.7 | 5.7 | -104 | 5 | ChEMBL | 345 | 6 | 0 | 4 | 3.8 | Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
46231924 | 203034 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -5 | 4 | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL599134 | 203034 | None | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -5 | 4 | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
154705128 | 176396 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -151 | 6 | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4454872 | 176396 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -151 | 6 | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595148 | 176396 | None | 1 | Human | Binding | pKi | = | 5.7 | 5.7 | -151 | 6 | ChEMBL | 462 | 12 | 1 | 3 | 6.0 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
156020558 | 178151 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -3 | 2 | ChEMBL | 347 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4647167 | 178151 | None | 0 | Human | Binding | pKi | = | 6.7 | 6.7 | -3 | 2 | ChEMBL | 347 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
11558247 | 75449 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 3 | ChEMBL | 282 | 0 | 2 | 3 | 2.6 | CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL204098 | 75449 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 3 | ChEMBL | 282 | 0 | 2 | 3 | 2.6 | CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 | 10.1021/jm051237e | |||
145969667 | 165060 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4225278 | 165060 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
44436301 | 90666 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
CHEMBL238915 | 90666 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2021.128028 | |||
44436301 | 90666 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL238915 | 90666 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6 | 4 | ChEMBL | 433 | 6 | 0 | 5 | 3.1 | O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C5MD00258C | |||
44209472 | 70196 | None | 1 | Human | Binding | pKi | = | 5.6 | 5.6 | -1318 | 11 | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940420 | 70196 | None | 1 | Human | Binding | pKi | = | 5.6 | 5.6 | -1318 | 11 | ChEMBL | 315 | 6 | 0 | 4 | 2.8 | Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
181743 | 178677 | None | 4 | Human | Binding | pKi | = | 5.6 | 5.6 | -1202 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
CHEMBL467094 | 178677 | None | 4 | Human | Binding | pKi | = | 5.6 | 5.6 | -1202 | 22 | ChEMBL | 339 | 2 | 0 | 5 | 3.2 | COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 | 10.1016/j.bmcl.2009.11.053 | |||
122177641 | 121273 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -38018 | 6 | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | |||
CHEMBL3577342 | 121273 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -38018 | 6 | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | |||
161665 | 172688 | None | 26 | Human | Binding | pKi | = | 6.6 | 6.6 | -3 | 5 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL448891 | 172688 | None | 26 | Human | Binding | pKi | = | 6.6 | 6.6 | -3 | 5 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
681 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
681.0 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
940 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
947 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
CHEMBL59 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
DB00988 | 1465 | None | 47 | Human | Binding | pKi | = | 5.6 | 5.6 | -67 | 38 | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1021/jm040889k | |||
6852376 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL1467585 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL24077 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL503958 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
76325152 | 106427 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115579 | 106427 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139262 | 106427 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
6852376 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL1467585 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL24077 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL503958 | 91633 | None | 9 | Human | Binding | pKi | = | 6.6 | 6.6 | 3 | 5 | ChEMBL | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 | 10.1016/j.bmcl.2013.12.024 | |||
156015018 | 177676 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 337 | 2 | 2 | 3 | 4.0 | COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4640497 | 177676 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 337 | 2 | 2 | 3 | 4.0 | COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
122177643 | 121275 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -15848 | 6 | ChEMBL | 632 | 20 | 3 | 9 | 5.1 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 | 10.1021/jm501889t | |||
CHEMBL3577344 | 121275 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -15848 | 6 | ChEMBL | 632 | 20 | 3 | 9 | 5.1 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 | 10.1021/jm501889t | |||
90644061 | 112096 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -2344 | 5 | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289646 | 112096 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -2344 | 5 | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
11610526 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
11610526.0 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
3928 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
5351 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
CHEMBL3039520 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
DB11732 | 2282 | None | 43 | Human | Binding | pKi | = | 6.6 | 6.6 | -74 | 7 | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.6019/CHEMBL5442175 | |||
90644061 | 112096 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -2344 | 5 | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289646 | 112096 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -2344 | 5 | ChEMBL | 329 | 6 | 0 | 4 | 3.1 | Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
11223708 | 166404 | None | 0 | Rat | Binding | pKi | = | 6.6 | 6.6 | -16 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
CHEMBL427173 | 166404 | None | 0 | Rat | Binding | pKi | = | 6.6 | 6.6 | -16 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
46231848 | 202994 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -8 | 4 | ChEMBL | 396 | 1 | 1 | 3 | 4.1 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL598949 | 202994 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | -8 | 4 | ChEMBL | 396 | 1 | 1 | 3 | 4.1 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 6.6 | 6.6 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm9601720 | |||
11246806 | 13012 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1189734 | 13012 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL539334 | 13012 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11522476 | 74549 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 | 10.1021/jm050846j | |||
CHEMBL202924 | 74549 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -5 | 3 | ChEMBL | 311 | 2 | 0 | 3 | 3.3 | COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 | 10.1021/jm050846j | |||
156017805 | 177931 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -5 | 2 | ChEMBL | 343 | 4 | 1 | 3 | 4.2 | C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4643886 | 177931 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -5 | 2 | ChEMBL | 343 | 4 | 1 | 3 | 4.2 | C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 | 10.1016/j.bmcl.2020.127305 | |||
25212275 | 174525 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6309 | 6 | ChEMBL | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL455288 | 174525 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6309 | 6 | ChEMBL | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
25212276 | 190175 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -741 | 6 | ChEMBL | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL517244 | 190175 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -741 | 6 | ChEMBL | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
1530 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
3827 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
3827.0 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
7206 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
CHEMBL534 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
DB00920 | 2182 | None | 36 | Human | Binding | pKi | = | 5.6 | 5.6 | -2691 | 24 | ChEMBL | 309 | 0 | 0 | 3 | 4.0 | CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 | 10.6019/CHEMBL5442175 | |||
57391307 | 70187 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -389 | 7 | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940411 | 70187 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -389 | 7 | ChEMBL | 348 | 6 | 0 | 3 | 4.1 | Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
146025727 | 171788 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 4 | 27 | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
CHEMBL4466483 | 171788 | None | 0 | Human | Binding | pKi | = | 7.6 | 7.6 | 4 | 27 | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
11316709 | 168473 | None | 0 | Rat | Binding | pKi | = | 5.6 | 5.6 | -323 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | |||
CHEMBL434532 | 168473 | None | 0 | Rat | Binding | pKi | = | 5.6 | 5.6 | -323 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | |||
44591099 | 176294 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -1023 | 6 | ChEMBL | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL459350 | 176294 | None | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -1023 | 6 | ChEMBL | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
76325156 | 106446 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
CHEMBL3115585 | 106446 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
CHEMBL3139393 | 106446 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
76325156 | 106446 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
CHEMBL3115585 | 106446 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
CHEMBL3139393 | 106446 | None | 0 | Human | Binding | pKi | = | 4.6 | 4.6 | -12302 | 6 | ChEMBL | 263 | 7 | 2 | 3 | 3.3 | CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 | 10.1021/jm401384w | |||
164606105 | 194146 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -3 | 2 | ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | |||
CHEMBL5279730 | 194146 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -3 | 2 | ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | |||
46869265 | 16264 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -13 | 7 | ChEMBL | 295 | 1 | 3 | 3 | 3.1 | Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 | 10.1016/j.bmc.2010.07.052 | |||
CHEMBL1224527 | 16264 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -13 | 7 | ChEMBL | 295 | 1 | 3 | 3 | 3.1 | Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 | 10.1016/j.bmc.2010.07.052 | |||
122181326 | 121933 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -933 | 6 | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2014.12.012 | |||
CHEMBL3590077 | 121933 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -933 | 6 | ChEMBL | 413 | 8 | 1 | 5 | 4.2 | COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 | 10.1016/j.bmc.2014.12.012 | |||
57401820 | 70185 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -323 | 7 | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940409 | 70185 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -323 | 7 | ChEMBL | 364 | 6 | 0 | 3 | 4.8 | Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
42611190 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
5802 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
42611190 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
5802 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pKi | = | 5.6 | 5.6 | -4265 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
147326216 | 196748 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -28 | 15 | ChEMBL | 424 | 10 | 2 | 6 | 4.3 | CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2cc(F)cc3cccnc23)cn1 | 10.1021/acs.jmedchem.2c01769 | |||
CHEMBL5431371 | 196748 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | -28 | 15 | ChEMBL | 424 | 10 | 2 | 6 | 4.3 | CCN(CC)CCCC(C)Nc1cnc(C(=O)Nc2cc(F)cc3cccnc23)cn1 | 10.1021/acs.jmedchem.2c01769 | |||
CHEMBL4566600 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL4507292 | |||||
CHEMBL4745071 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL4507292 | |||||
CHEMBL4566600 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL5212743 | |||||
CHEMBL4745071 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL5212743 | |||||
145967572 | 165028 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -56 | 6 | ChEMBL | 275 | 8 | 1 | 2 | 4.5 | CCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4224763 | 165028 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -56 | 6 | ChEMBL | 275 | 8 | 1 | 2 | 4.5 | CCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4566600 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL4507292 | |||||
CHEMBL4745071 | 216486 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1 | 6 | ChEMBL | None | None | None | Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12 | 10.6019/CHEMBL4507292 | |||||
76325152 | 106427 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115579 | 106427 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139262 | 106427 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -251 | 5 | ChEMBL | 359 | 9 | 2 | 4 | 4.0 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 | 10.1021/jm401384w | |||
122181329 | 121936 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -9332 | 6 | ChEMBL | 394 | 10 | 1 | 2 | 4.6 | CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
CHEMBL3590080 | 121936 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -9332 | 6 | ChEMBL | 394 | 10 | 1 | 2 | 4.6 | CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
10531 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
10531.0 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
121 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
888 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
CHEMBL1732 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
DB00320 | 1420 | None | 13 | Human | Binding | pKi | = | 5.5 | 5.5 | -7762 | 30 | ChEMBL | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 10.6019/CHEMBL5442175 | |||
44591135 | 190286 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -190 | 6 | ChEMBL | 532 | 10 | 0 | 4 | 8.0 | CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL517407 | 190286 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -190 | 6 | ChEMBL | 532 | 10 | 0 | 4 | 8.0 | CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | 10.1016/j.bmcl.2008.09.012 | |||
122205437 | 137398 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 7 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2sccc2CC1 | 10.1039/C5MD00258C | |||
CHEMBL3752512 | 137398 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | 7 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2sccc2CC1 | 10.1039/C5MD00258C | |||
6603703 | 208 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 12 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442175 | |||
9637 | 208 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 12 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442175 | |||
CHEMBL291143 | 208 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | 1 | 12 | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442175 | |||
11486421 | 203651 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 3 | ChEMBL | 400 | 2 | 2 | 4 | 4.5 | CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL603485 | 203651 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 3 | ChEMBL | 400 | 2 | 2 | 4 | 4.5 | CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
46231846 | 203796 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | 341 | 1 | 1 | 3 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL604316 | 203796 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -1 | 4 | ChEMBL | 341 | 1 | 1 | 3 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
46231849 | 203875 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 4 | ChEMBL | 356 | 1 | 2 | 4 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL604732 | 203875 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 4 | ChEMBL | 356 | 1 | 2 | 4 | 3.8 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
46231994 | 202864 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -5 | 4 | ChEMBL | 414 | 1 | 1 | 3 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL598105 | 202864 | None | 0 | Human | Binding | pKi | = | 8.5 | 8.5 | -5 | 4 | ChEMBL | 414 | 1 | 1 | 3 | 5.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
44439942 | 151954 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -4 | 4 | ChEMBL | 320 | 1 | 1 | 2 | 3.8 | COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL396560 | 151954 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -4 | 4 | ChEMBL | 320 | 1 | 1 | 2 | 3.8 | COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3 | 10.1016/j.bmcl.2006.11.093 | |||
46231782 | 202959 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 371 | 1 | 1 | 4 | 3.8 | COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL598730 | 202959 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -1 | 4 | ChEMBL | 371 | 1 | 1 | 4 | 3.8 | COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.094 | |||
46231541 | 202644 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 370 | 4 | 2 | 3 | 4.3 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL596622 | 202644 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 370 | 4 | 2 | 3 | 4.3 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
1243 | 3618 | None | 30 | Human | Binding | pKi | = | 8.4 | 8.4 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127305 | |||
944 | 3618 | None | 30 | Human | Binding | pKi | = | 8.4 | 8.4 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL324017 | 3618 | None | 30 | Human | Binding | pKi | = | 8.4 | 8.4 | -2 | 15 | ChEMBL | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 10.1016/j.bmcl.2020.127305 | |||
164609519 | 184557 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -251 | 5 | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | |||
CHEMBL4846574 | 184557 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -251 | 5 | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2 | 10.1016/j.bmcl.2021.128047 | |||
172444635 | 195411 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1905 | 9 | ChEMBL | 488 | 10 | 2 | 5 | 4.4 | COc1ccc(-c2ccccc2)c(CNC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/acs.jmedchem.3c00537 | |||
CHEMBL5403204 | 195411 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1905 | 9 | ChEMBL | 488 | 10 | 2 | 5 | 4.4 | COc1ccc(-c2ccccc2)c(CNC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 | 10.1021/acs.jmedchem.3c00537 | |||
137646281 | 157898 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -6918 | 17 | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | |||
CHEMBL4083252 | 157898 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -6918 | 17 | ChEMBL | 423 | 8 | 0 | 7 | 3.8 | COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 | 10.1021/acs.jmedchem.9b00412 | |||
72301 | 186224 | None | 46 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 4 | ChEMBL | 355 | 4 | 0 | 5 | 3.4 | COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL487182 | 186224 | None | 46 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 4 | ChEMBL | 355 | 4 | 0 | 5 | 3.4 | COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
10801923 | 177869 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -2 | 2 | ChEMBL | 269 | 2 | 2 | 3 | 2.7 | COc1cc2c(cc1O)C(c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4642805 | 177869 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -2 | 2 | ChEMBL | 269 | 2 | 2 | 3 | 2.7 | COc1cc2c(cc1O)C(c1ccccc1)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
44415690 | 80168 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -14 | 6 | ChEMBL | 473 | 2 | 1 | 5 | 5.1 | Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL213336 | 80168 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -14 | 6 | ChEMBL | 473 | 2 | 1 | 5 | 5.1 | Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
44439944 | 151958 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -1 | 4 | ChEMBL | 320 | 1 | 1 | 2 | 3.8 | COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL396561 | 151958 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | -1 | 4 | ChEMBL | 320 | 1 | 1 | 2 | 3.8 | COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2 | 10.1016/j.bmcl.2006.11.093 | |||
145968810 | 165133 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -33 | 6 | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4226226 | 165133 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -33 | 6 | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | |||
42626293 | 151214 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -4 | 5 | ChEMBL | 349 | 6 | 0 | 3 | 3.2 | O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL395933 | 151214 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -4 | 5 | ChEMBL | 349 | 6 | 0 | 3 | 3.2 | O=C1Cc2ccccc2N1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
11186895 | 87541 | None | 22 | Human | Binding | pKi | = | 6.5 | 6.5 | -7 | 4 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL2334885 | 87541 | None | 22 | Human | Binding | pKi | = | 6.5 | 6.5 | -7 | 4 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21 | 10.1016/j.bmcl.2017.01.090 | |||
17755991 | 152387 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 5 | ChEMBL | 267 | 0 | 2 | 2 | 3.1 | Oc1ccc2c(c1)CCCNCCc1ccccc1C2 | 10.1021/jm070388+ | |||
CHEMBL396950 | 152387 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 5 | ChEMBL | 267 | 0 | 2 | 2 | 3.1 | Oc1ccc2c(c1)CCCNCCc1ccccc1C2 | 10.1021/jm070388+ | |||
90644063 | 112098 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -138 | 10 | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289648 | 112098 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -138 | 10 | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
11394805 | 13992 | None | 0 | Human | Binding | pKi | = | 4.5 | 4.5 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196936 | 13992 | None | 0 | Human | Binding | pKi | = | 4.5 | 4.5 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL558766 | 13992 | None | 0 | Human | Binding | pKi | = | 4.5 | 4.5 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
57401706 | 70195 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -562 | 11 | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940419 | 70195 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -562 | 11 | ChEMBL | 331 | 6 | 0 | 4 | 3.5 | Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
90644063 | 112098 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -138 | 10 | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL3289648 | 112098 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -138 | 10 | ChEMBL | 327 | 6 | 0 | 3 | 3.7 | Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1 | 10.1016/j.bmc.2014.04.026 | |||
44436307 | 91792 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 19 | 3 | ChEMBL | 383 | 6 | 0 | 3 | 3.9 | O=C1c2ccccc2CN1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL240995 | 91792 | None | 0 | Human | Binding | pKi | = | 7.5 | 7.5 | 19 | 3 | ChEMBL | 383 | 6 | 0 | 3 | 3.9 | O=C1c2ccccc2CN1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
10667433 | 148886 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -10 | 4 | ChEMBL | 379 | 7 | 0 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL394080 | 148886 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -10 | 4 | ChEMBL | 379 | 7 | 0 | 4 | 3.2 | COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc32)CC1 | 10.1016/j.bmc.2007.06.002 | |||
172458734 | 196494 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -6165 | 9 | ChEMBL | 458 | 9 | 2 | 4 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NCc2ccccc2-c2ccccc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
CHEMBL5425252 | 196494 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -6165 | 9 | ChEMBL | 458 | 9 | 2 | 4 | 4.4 | COc1ccccc1N1CCN(CCCNC(=O)NCc2ccccc2-c2ccccc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
1621 | 2429 | None | 10 | Human | Binding | pKi | = | 6.5 | 6.5 | -151 | 44 | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
17 | 2429 | None | 10 | Human | Binding | pKi | = | 6.5 | 6.5 | -151 | 44 | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
5761 | 2429 | None | 10 | Human | Binding | pKi | = | 6.5 | 6.5 | -151 | 44 | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
CHEMBL263881 | 2429 | None | 10 | Human | Binding | pKi | = | 6.5 | 6.5 | -151 | 44 | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
DB04829 | 2429 | None | 10 | Human | Binding | pKi | = | 6.5 | 6.5 | -151 | 44 | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
155515982 | 170113 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -1348 | 17 | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | |||
CHEMBL4442460 | 170113 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -1348 | 17 | ChEMBL | 473 | 10 | 2 | 5 | 4.1 | COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1 | 10.1021/acs.jmedchem.9b01085 | |||
164626655 | 186699 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -100 | 5 | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | |||
CHEMBL4878587 | 186699 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -100 | 5 | ChEMBL | 441 | 7 | 1 | 5 | 4.1 | COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2 | 10.1016/j.bmcl.2021.128047 | |||
137636498 | 156287 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1479 | 6 | ChEMBL | 446 | 7 | 2 | 6 | 3.8 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4064186 | 156287 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -1479 | 6 | ChEMBL | 446 | 7 | 2 | 6 | 3.8 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
11978813 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
11978813.0 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
5014 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
7672 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
CHEMBL2105760 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
DB09128 | 721 | None | 58 | Human | Binding | pKi | = | 6.5 | 6.5 | -371 | 27 | ChEMBL | 433 | 7 | 1 | 5 | 4.7 | O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 | 10.6019/CHEMBL5442175 | |||
76321556 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115578 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139302 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
76321556 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115578 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139302 | 106433 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -363 | 5 | ChEMBL | 493 | 6 | 2 | 5 | 3.1 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2 | 10.1021/jm401384w | |||
168510312 | 194964 | None | 2 | Human | Binding | pKi | = | 6.5 | 6.5 | -218 | 9 | ChEMBL | 520 | 9 | 2 | 4 | 6.4 | COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
CHEMBL5394229 | 194964 | None | 2 | Human | Binding | pKi | = | 6.5 | 6.5 | -218 | 9 | ChEMBL | 520 | 9 | 2 | 4 | 6.4 | COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccc(-c3ccccc3)cc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
154703824 | 176731 | None | 1 | Human | Binding | pKi | = | 5.5 | 5.5 | -1348 | 6 | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4456007 | 176731 | None | 1 | Human | Binding | pKi | = | 5.5 | 5.5 | -1348 | 6 | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597876 | 176731 | None | 1 | Human | Binding | pKi | = | 5.5 | 5.5 | -1348 | 6 | ChEMBL | 471 | 11 | 2 | 2 | 6.5 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
763774 | 92183 | None | 2 | Human | Binding | pKi | = | 5.5 | 5.5 | -16 | 2 | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | |||
CHEMBL2420776 | 92183 | None | 2 | Human | Binding | pKi | = | 5.5 | 5.5 | -16 | 2 | ChEMBL | 292 | 3 | 0 | 3 | 3.7 | Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1 | 10.1016/j.bmcl.2013.07.033 | |||
76321554 | 106459 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115574 | 106459 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139450 | 106459 | None | 0 | Human | Binding | pKi | = | 5.5 | 5.5 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
122191605 | 123787 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -181 | 5 | ChEMBL | 426 | 7 | 2 | 3 | 4.2 | Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/acsmedchemlett.5b00131 | |||
CHEMBL3622097 | 123787 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -181 | 5 | ChEMBL | 426 | 7 | 2 | 3 | 4.2 | Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1 | 10.1021/acsmedchemlett.5b00131 | |||
9992499 | 73411 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 4 | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | |||
CHEMBL201483 | 73411 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 4 | ChEMBL | 254 | 0 | 0 | 2 | 2.6 | CN1CCc2ccccc2Cc2ccn(C)c2CC1 | 10.1021/jm050846j | |||
2993172 | 127235 | None | 2 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 3 | ChEMBL | 297 | 6 | 0 | 3 | 3.0 | c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 | 10.1021/jm049720x | |||
CHEMBL365697 | 127235 | None | 2 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 3 | ChEMBL | 297 | 6 | 0 | 3 | 3.0 | c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1 | 10.1021/jm049720x | |||
10476504 | 33495 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -154 | 7 | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL142020 | 33495 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -154 | 7 | ChEMBL | 407 | 8 | 1 | 6 | 2.7 | COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1 | 10.1016/j.bmc.2017.04.036 | |||
10378389 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
CHEMBL134807 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
CHEMBL64553 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
76321554 | 106459 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115574 | 106459 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139450 | 106459 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -2290 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2 | 10.1021/jm401384w | |||
44415569 | 166029 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -23 | 6 | ChEMBL | 505 | 4 | 1 | 7 | 4.5 | COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL425069 | 166029 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -23 | 6 | ChEMBL | 505 | 4 | 1 | 7 | 4.5 | COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
75201901 | 166520 | None | 21 | Human | Binding | pKi | = | 7.4 | 7.4 | 1 | 24 | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
CHEMBL4277264 | 166520 | None | 21 | Human | Binding | pKi | = | 7.4 | 7.4 | 1 | 24 | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 7.4 | 7.4 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm1013693 | |||
44408818 | 140252 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL380330 | 140252 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmcl.2006.11.093 | |||
122180956 | 121836 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -380 | 6 | ChEMBL | 404 | 7 | 1 | 3 | 4.8 | CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
CHEMBL3589577 | 121836 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -380 | 6 | ChEMBL | 404 | 7 | 1 | 3 | 4.8 | CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
137635364 | 156351 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -12302 | 6 | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL4064974 | 156351 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -12302 | 6 | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL4074669 | 156351 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -12302 | 6 | ChEMBL | 439 | 10 | 1 | 6 | 3.0 | O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1 | 10.1016/j.bmc.2017.04.036 | |||
57393083 | 70191 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -616 | 7 | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940415 | 70191 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -616 | 7 | ChEMBL | 314 | 6 | 0 | 4 | 2.8 | Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
10378389 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
CHEMBL134807 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
CHEMBL64553 | 205703 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -8128 | 7 | ChEMBL | 269 | 4 | 2 | 3 | 2.9 | Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2 | 10.1021/jm401384w | |||
56594533 | 70622 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | 1 | 2 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | |||
CHEMBL1949726 | 70622 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | 1 | 2 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | |||
172458161 | 196394 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -1862 | 9 | ChEMBL | 562 | 15 | 2 | 7 | 4.7 | COCCOCCOc1ccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c(-c2ccccc2)c1 | 10.1021/acs.jmedchem.3c00537 | |||
CHEMBL5422870 | 196394 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -1862 | 9 | ChEMBL | 562 | 15 | 2 | 7 | 4.7 | COCCOCCOc1ccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c(-c2ccccc2)c1 | 10.1021/acs.jmedchem.3c00537 | |||
3929516 | 107426 | None | 4 | Human | Binding | pKi | = | 6.4 | 6.4 | -66 | 17 | ChEMBL | 343 | 4 | 0 | 2 | 4.7 | CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 | 10.6019/CHEMBL5442175 | |||
CHEMBL317757 | 107426 | None | 4 | Human | Binding | pKi | = | 6.4 | 6.4 | -66 | 17 | ChEMBL | 343 | 4 | 0 | 2 | 4.7 | CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 | 10.6019/CHEMBL5442175 | |||
CHEMBL543113 | 107426 | None | 4 | Human | Binding | pKi | = | 6.4 | 6.4 | -66 | 17 | ChEMBL | 343 | 4 | 0 | 2 | 4.7 | CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 | 10.6019/CHEMBL5442175 | |||
132060461 | 195423 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -199 | 19 | ChEMBL | 421 | 6 | 0 | 4 | 4.9 | CCCN1CCN(c2ccc3c(c2)C(N(C)C(=O)OCc2ccccc2)CCC3)CC1 | 10.1016/j.ejmech.2022.114696 | |||
CHEMBL5403404 | 195423 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -199 | 19 | ChEMBL | 421 | 6 | 0 | 4 | 4.9 | CCCN1CCN(c2ccc3c(c2)C(N(C)C(=O)OCc2ccccc2)CCC3)CC1 | 10.1016/j.ejmech.2022.114696 | |||
168269421 | 190071 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -26 | 3 | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | |||
CHEMBL5170670 | 190071 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -26 | 3 | ChEMBL | 390 | 5 | 1 | 2 | 5.3 | Fc1ccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)cc1F | 10.1016/j.bmcl.2022.128615 | |||
6917970 | 3691 | None | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | |||
8370 | 3691 | None | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL487387 | 3691 | None | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | ChEMBL | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | 10.1016/j.bmc.2009.08.028 | |||
56589560 | 70621 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 5 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | |||
CHEMBL1949725 | 70621 | None | 0 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 5 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C | 10.1021/jm200676f | |||
17756101 | 98637 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | |||
CHEMBL276778 | 98637 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | |||
46231995 | 203991 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 4 | ChEMBL | 434 | 2 | 1 | 4 | 5.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL605339 | 203991 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 4 | ChEMBL | 434 | 2 | 1 | 4 | 5.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
11573628 | 74725 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 | 10.1021/jm051237e | |||
CHEMBL203047 | 74725 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 301 | 0 | 1 | 2 | 3.7 | CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 | 10.1021/jm051237e | |||
10472143 | 119341 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -891 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
CHEMBL343755 | 119341 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -891 | 16 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
154703922 | 176394 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -1995 | 6 | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4590211 | 176394 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -1995 | 6 | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595146 | 176394 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -1995 | 6 | ChEMBL | 482 | 11 | 1 | 2 | 7.2 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl | 10.1021/acs.jmedchem.9b01835 | |||
13373172 | 202239 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 3 | 5 | ChEMBL | 251 | 0 | 1 | 2 | 3.0 | Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL593897 | 202239 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | 3 | 5 | ChEMBL | 251 | 0 | 1 | 2 | 3.0 | Oc1ccc2c(c1)CCN1Cc3ccccc3CC21 | 10.1016/j.bmc.2009.08.028 | |||
44414299 | 139312 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -19 | 2 | ChEMBL | 495 | 9 | 0 | 4 | 6.6 | CCN(CC)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 | 10.1016/j.bmcl.2006.05.025 | |||
CHEMBL378825 | 139312 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -19 | 2 | ChEMBL | 495 | 9 | 0 | 4 | 6.6 | CCN(CC)CCCOc1cccc(N2C(=O)/C(=N/c3cccc(C(F)(F)F)c3)c3ccccc32)c1 | 10.1016/j.bmcl.2006.05.025 | |||
2402 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
5095 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
5095.0 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
7295 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
CHEMBL589 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
DB00268 | 3370 | None | 38 | Human | Binding | pKi | = | 4.4 | 4.4 | -81 | 25 | ChEMBL | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | 10.1039/C4MD00066H | |||
135409453 | 3773 | None | 26 | Human | Binding | pKi | = | 5.4 | 5.4 | -537 | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.6019/CHEMBL5442175 | |||
226 | 3773 | None | 26 | Human | Binding | pKi | = | 5.4 | 5.4 | -537 | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.6019/CHEMBL5442175 | |||
CHEMBL76370 | 3773 | None | 26 | Human | Binding | pKi | = | 5.4 | 5.4 | -537 | 19 | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.6019/CHEMBL5442175 | |||
7077 | 66980 | None | 21 | Human | Binding | pKi | = | 6.4 | 6.4 | -4 | 5 | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | |||
CHEMBL186720 | 66980 | None | 21 | Human | Binding | pKi | = | 6.4 | 6.4 | -4 | 5 | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | |||
CHEMBL3925724 | 66980 | None | 21 | Human | Binding | pKi | = | 6.4 | 6.4 | -4 | 5 | ChEMBL | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | 10.1021/jm049720x | |||
57403525 | 70178 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -275 | 10 | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
CHEMBL1940402 | 70178 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -275 | 10 | ChEMBL | 361 | 6 | 1 | 2 | 4.8 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2014.07.018 | |||
156012196 | 177437 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 4 | ChEMBL | 296 | 1 | 2 | 4 | 2.7 | COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2 | 10.1016/j.bmcl.2020.127053 | |||
CHEMBL4637246 | 177437 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 4 | ChEMBL | 296 | 1 | 2 | 4 | 2.7 | COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2 | 10.1016/j.bmcl.2020.127053 | |||
11716438 | 140969 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -8 | 4 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm051237e | |||
CHEMBL382010 | 140969 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -8 | 4 | ChEMBL | 267 | 0 | 1 | 2 | 3.0 | CN1CCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm051237e | |||
137640189 | 157045 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -5495 | 6 | ChEMBL | 466 | 7 | 3 | 7 | 2.6 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4072780 | 157045 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -5495 | 6 | ChEMBL | 466 | 7 | 3 | 7 | 2.6 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
164614469 | 184887 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 341 | 1 | 0 | 3 | 3.9 | C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
CHEMBL4851349 | 184887 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 341 | 1 | 0 | 3 | 3.9 | C[Si](C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2021.128008 | |||
154726353 | 176428 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -371 | 6 | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4577162 | 176428 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -371 | 6 | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595382 | 176428 | None | 1 | Human | Binding | pKi | = | 5.4 | 5.4 | -371 | 6 | ChEMBL | 467 | 12 | 2 | 3 | 5.9 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
4011 | 82440 | None | 34 | Human | Binding | pKi | = | 6.4 | 6.4 | -57 | 23 | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL21731 | 82440 | None | 34 | Human | Binding | pKi | = | 6.4 | 6.4 | -57 | 23 | ChEMBL | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | 10.1016/j.bmcl.2008.09.012 | |||
44396220 | 125490 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/jm049720x | |||
CHEMBL364565 | 125490 | None | 0 | Human | Binding | pKi | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 295 | 6 | 0 | 2 | 4.1 | c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1 | 10.1021/jm049720x | |||
11212939 | 69182 | None | 0 | Rat | Binding | pKi | = | 5.4 | 5.4 | -45 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | |||
CHEMBL192439 | 69182 | None | 0 | Rat | Binding | pKi | = | 5.4 | 5.4 | -45 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 | 10.1021/jm049031l | |||
145988693 | 167262 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -17 | 17 | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL4291048 | 167262 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -17 | 17 | ChEMBL | 524 | 7 | 1 | 3 | 7.1 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
145969934 | 165140 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -39 | 6 | ChEMBL | 261 | 7 | 1 | 2 | 4.2 | CCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4226336 | 165140 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -39 | 6 | ChEMBL | 261 | 7 | 1 | 2 | 4.2 | CCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
155770281 | 177852 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -5 | 9 | ChEMBL | 517 | 4 | 1 | 2 | 7.6 | CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.0c00745 | |||
CHEMBL4642592 | 177852 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -5 | 9 | ChEMBL | 517 | 4 | 1 | 2 | 7.6 | CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.0c00745 | |||
156011597 | 177484 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -3 | 2 | ChEMBL | 373 | 3 | 2 | 3 | 4.0 | C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4637938 | 177484 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -3 | 2 | ChEMBL | 373 | 3 | 2 | 3 | 4.0 | C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
172438970 | 195292 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -776 | 9 | ChEMBL | 444 | 8 | 2 | 4 | 4.7 | COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccccc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
CHEMBL5400232 | 195292 | None | 0 | Human | Binding | pKi | = | 5.4 | 5.4 | -776 | 9 | ChEMBL | 444 | 8 | 2 | 4 | 4.7 | COc1ccccc1N1CCN(CCCNC(=O)Nc2ccccc2-c2ccccc2)CC1 | 10.1021/acs.jmedchem.3c00537 | |||
76325150 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115575 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139554 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
156017431 | 177882 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -3 | 2 | ChEMBL | 317 | 2 | 1 | 3 | 3.7 | COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4643069 | 177882 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -3 | 2 | ChEMBL | 317 | 2 | 1 | 3 | 3.7 | COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
76325150 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115575 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139554 | 106478 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -4897 | 5 | ChEMBL | 395 | 4 | 2 | 3 | 3.5 | Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2 | 10.1021/jm401384w | |||
130442572 | 172011 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 3 | 24 | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
CHEMBL4469848 | 172011 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 3 | 24 | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
156018764 | 177900 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 2 | ChEMBL | 361 | 2 | 1 | 3 | 3.8 | COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4643426 | 177900 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 2 | ChEMBL | 361 | 2 | 1 | 3 | 3.8 | COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
156018236 | 178017 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 377 | 4 | 1 | 3 | 4.9 | C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4645139 | 178017 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 2 | 3 | ChEMBL | 377 | 4 | 1 | 3 | 4.9 | C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1 | 10.1016/j.bmcl.2020.127305 | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1016/j.bmcl.2011.04.098 | |||
122177642 | 121274 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | -21877 | 6 | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | |||
CHEMBL3577343 | 121274 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | -21877 | 6 | ChEMBL | 551 | 18 | 1 | 8 | 4.6 | C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 | 10.1021/jm501889t | |||
156014482 | 177317 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -3 | 2 | ChEMBL | 303 | 2 | 2 | 3 | 3.3 | COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4635423 | 177317 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -3 | 2 | ChEMBL | 303 | 2 | 2 | 3 | 3.3 | COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
156010755 | 177246 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 2 | 2 | ChEMBL | 351 | 2 | 1 | 3 | 4.3 | COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4633950 | 177246 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | 2 | 2 | ChEMBL | 351 | 2 | 1 | 3 | 4.3 | COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2 | 10.1016/j.bmcl.2020.127305 | |||
5074 | 3332 | None | 53 | Human | Binding | pKi | = | 6.3 | 6.3 | -741 | 37 | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.6019/CHEMBL5442175 | |||
97 | 3332 | None | 53 | Human | Binding | pKi | = | 6.3 | 6.3 | -741 | 37 | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.6019/CHEMBL5442175 | |||
CHEMBL267777 | 3332 | None | 53 | Human | Binding | pKi | = | 6.3 | 6.3 | -741 | 37 | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.6019/CHEMBL5442175 | |||
DB12693 | 3332 | None | 53 | Human | Binding | pKi | = | 6.3 | 6.3 | -741 | 37 | ChEMBL | 477 | 5 | 0 | 5 | 5.5 | Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F | 10.6019/CHEMBL5442175 | |||
44439945 | 93420 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 306 | 0 | 2 | 2 | 3.5 | CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL245571 | 93420 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 306 | 0 | 2 | 2 | 3.5 | CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
168280742 | 191193 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 230 | 4 | 0 | 2 | 3.5 | O=Cc1ccc(-c2ccccc2OCF)cc1 | 10.1021/acs.jmedchem.2c00949 | |||
CHEMBL5187578 | 191193 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 4 | ChEMBL | 230 | 4 | 0 | 2 | 3.5 | O=Cc1ccc(-c2ccccc2OCF)cc1 | 10.1021/acs.jmedchem.2c00949 | |||
11452916 | 203285 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 3 | ChEMBL | 420 | 3 | 2 | 4 | 3.7 | CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL600986 | 203285 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 3 | ChEMBL | 420 | 3 | 2 | 4 | 3.7 | CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
44275670 | 11993 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 457 | 8 | 2 | 5 | 3.7 | COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 | 10.1021/jm030480f | |||
CHEMBL1183144 | 11993 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 457 | 8 | 2 | 5 | 3.7 | COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 | 10.1021/jm030480f | |||
CHEMBL282116 | 11993 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 457 | 8 | 2 | 5 | 3.7 | COc1cccc(CN2CC[C@H](NC(=O)c3cc(Cl)c(NC(=O)C4CC4)cc3OC)C2)c1 | 10.1021/jm030480f | |||
11235174 | 202837 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -11 | 3 | ChEMBL | 406 | 2 | 2 | 4 | 3.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL597909 | 202837 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -11 | 3 | ChEMBL | 406 | 2 | 2 | 4 | 3.4 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
11374299 | 203064 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -11 | 3 | ChEMBL | 448 | 5 | 1 | 4 | 4.0 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL599282 | 203064 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -11 | 3 | ChEMBL | 448 | 5 | 1 | 4 | 4.0 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1 | 10.1016/j.bmcl.2009.12.100 | |||
156020547 | 178263 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -12 | 2 | ChEMBL | 387 | 4 | 1 | 3 | 4.3 | C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4649012 | 178263 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -12 | 2 | ChEMBL | 387 | 4 | 1 | 3 | 4.3 | C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1 | 10.1016/j.bmcl.2020.127305 | |||
44436304 | 90483 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -3 | 3 | ChEMBL | 396 | 6 | 0 | 5 | 3.7 | O=c1c2ccccc2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL238718 | 90483 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -3 | 3 | ChEMBL | 396 | 6 | 0 | 5 | 3.7 | O=c1c2ccccc2ncn1CCCCN1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
44427970 | 152699 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 5 | ChEMBL | 325 | 2 | 0 | 3 | 3.7 | COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | |||
CHEMBL397207 | 152699 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | 1 | 5 | ChEMBL | 325 | 2 | 0 | 3 | 3.7 | COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | |||
56593482 | 3941 | None | 6 | Human | Binding | pKi | = | 6.3 | 6.3 | -467 | 9 | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
7650 | 3941 | None | 6 | Human | Binding | pKi | = | 6.3 | 6.3 | -467 | 9 | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
CHEMBL2165119 | 3941 | None | 6 | Human | Binding | pKi | = | 6.3 | 6.3 | -467 | 9 | ChEMBL | 462 | 7 | 1 | 5 | 4.6 | O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
71528209 | 87006 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -812 | 7 | ChEMBL | 465 | 6 | 0 | 3 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F | 10.1021/ml300383n | |||
CHEMBL2323582 | 87006 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | -812 | 7 | ChEMBL | 465 | 6 | 0 | 3 | 5.8 | CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F | 10.1021/ml300383n | |||
53325242 | 57086 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -2 | 17 | ChEMBL | 537 | 8 | 1 | 2 | 7.9 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL1644978 | 57086 | None | 0 | Human | Binding | pKi | = | 6.3 | 6.3 | -2 | 17 | ChEMBL | 537 | 8 | 1 | 2 | 7.9 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
44415689 | 139196 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -58 | 6 | ChEMBL | 494 | 2 | 2 | 6 | 4.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL378669 | 139196 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -58 | 6 | ChEMBL | 494 | 2 | 2 | 6 | 4.7 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
17756102 | 86178 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 5 | ChEMBL | 309 | 1 | 0 | 2 | 4.1 | COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | |||
CHEMBL231171 | 86178 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -2 | 5 | ChEMBL | 309 | 1 | 0 | 2 | 4.1 | COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2 | 10.1021/jm070388+ | |||
44408818 | 140252 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | |||
CHEMBL380330 | 140252 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | |||
44408818 | 140252 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmc.2009.08.028 | |||
CHEMBL380330 | 140252 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -12 | 6 | ChEMBL | 281 | 1 | 0 | 2 | 3.3 | COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 | 10.1016/j.bmc.2009.08.028 | |||
11441173 | 13965 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196699 | 13965 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL557840 | 13965 | None | 0 | Human | Binding | pKi | = | 4.3 | 4.3 | - | 1 | ChEMBL | 327 | 6 | 1 | 2 | 4.7 | CCCN(CCC)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
17755999 | 142972 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -9 | 6 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | |||
CHEMBL389357 | 142972 | None | 0 | Human | Binding | pKi | = | 7.3 | 7.3 | -9 | 6 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2 | 10.1021/jm070388+ | |||
154725813 | 176631 | None | 1 | Human | Binding | pKi | = | 5.3 | 5.3 | -213 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4568916 | 176631 | None | 1 | Human | Binding | pKi | = | 5.3 | 5.3 | -213 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597047 | 176631 | None | 1 | Human | Binding | pKi | = | 5.3 | 5.3 | -213 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
137643132 | 158142 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -4786 | 6 | ChEMBL | 503 | 7 | 1 | 7 | 3.8 | CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL4085920 | 158142 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -4786 | 6 | ChEMBL | 503 | 7 | 1 | 7 | 3.8 | CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1 | 10.1016/j.bmc.2017.04.036 | |||
154703541 | 176404 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -24 | 6 | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4541924 | 176404 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -24 | 6 | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595195 | 176404 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -24 | 6 | ChEMBL | 464 | 11 | 1 | 3 | 6.1 | CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
21509921 | 104514 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -56 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104091 | 104514 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -56 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
154705296 | 176499 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -134 | 5 | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4444691 | 176499 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -134 | 5 | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595970 | 176499 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -134 | 5 | ChEMBL | 482 | 11 | 1 | 2 | 6.9 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
44415704 | 80190 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -19 | 6 | ChEMBL | 474 | 2 | 2 | 6 | 4.4 | Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL213424 | 80190 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -19 | 6 | ChEMBL | 474 | 2 | 2 | 6 | 4.4 | Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21 | 10.1016/j.bmcl.2006.06.022 | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 7.2 | 7.2 | -54 | 85 | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1021/jm049720x | |||
137635685 | 156096 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -199 | 6 | ChEMBL | 417 | 7 | 1 | 7 | 3.6 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4061986 | 156096 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -199 | 6 | ChEMBL | 417 | 7 | 1 | 7 | 3.6 | Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12 | 10.1021/acs.jmedchem.7b00363 | |||
21509921 | 104514 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -56 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
CHEMBL3104091 | 104514 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -56 | 24 | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
154704705 | 176430 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -2 | 5 | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4590356 | 176430 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -2 | 5 | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595409 | 176430 | None | 1 | Human | Binding | pKi | = | 6.2 | 6.2 | -2 | 5 | ChEMBL | 440 | 11 | 1 | 6 | 4.9 | CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
11121216 | 30147 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -295 | 14 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
CHEMBL138989 | 30147 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -295 | 14 | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
11198948 | 13720 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1194996 | 13720 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL553690 | 13720 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
46232066 | 203713 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -8 | 4 | ChEMBL | 419 | 2 | 1 | 3 | 5.7 | COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL603872 | 203713 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -8 | 4 | ChEMBL | 419 | 2 | 1 | 3 | 5.7 | COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1 | 10.1016/j.bmcl.2009.12.094 | |||
171347340 | 194310 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 375 | 2 | 1 | 4 | 3.5 | O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | |||
CHEMBL5283362 | 194310 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 375 | 2 | 1 | 4 | 3.5 | O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | |||
145970938 | 165251 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -4 | 5 | ChEMBL | 233 | 5 | 1 | 2 | 3.4 | CCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4228054 | 165251 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -4 | 5 | ChEMBL | 233 | 5 | 1 | 2 | 3.4 | CCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
154705884 | 176468 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -190 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4469584 | 176468 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -190 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595726 | 176468 | None | 1 | Human | Binding | pKi | = | 5.2 | 5.2 | -190 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
56597938 | 3940 | None | 4 | Human | Binding | pKi | = | 6.2 | 6.2 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
7651 | 3940 | None | 4 | Human | Binding | pKi | = | 6.2 | 6.2 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
CHEMBL2165126 | 3940 | None | 4 | Human | Binding | pKi | = | 6.2 | 6.2 | -1380 | 9 | ChEMBL | 461 | 7 | 1 | 4 | 5.2 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl | nan | |||
21171 | 187082 | None | 25 | Human | Binding | pKi | = | 7.2 | 7.2 | -1 | 5 | ChEMBL | 339 | 2 | 0 | 5 | 3.1 | COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL490533 | 187082 | None | 25 | Human | Binding | pKi | = | 7.2 | 7.2 | -1 | 5 | ChEMBL | 339 | 2 | 0 | 5 | 3.1 | COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 | 10.1016/j.bmcl.2017.01.090 | |||
11406143 | 66153 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 2 | 4 | ChEMBL | 372 | 7 | 0 | 3 | 4.5 | c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm049720x | |||
CHEMBL184073 | 66153 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | 2 | 4 | ChEMBL | 372 | 7 | 0 | 3 | 4.5 | c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1 | 10.1021/jm049720x | |||
145986752 | 167372 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -1 | 17 | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL4293307 | 167372 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -1 | 17 | ChEMBL | 562 | 10 | 1 | 5 | 7.3 | COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1 | 10.1016/j.bmcl.2018.10.036 | |||
3038495 | 708 | None | 33 | Rat | Binding | pKi | = | 6.2 | 6.2 | -407 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | |||
7625 | 708 | None | 33 | Rat | Binding | pKi | = | 6.2 | 6.2 | -407 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | |||
CHEMBL25236 | 708 | None | 33 | Rat | Binding | pKi | = | 6.2 | 6.2 | -407 | 27 | ChEMBL | 417 | 8 | 1 | 4 | 4.2 | COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 | 10.1021/jm049031l | |||
145969667 | 165060 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4225278 | 165060 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -41 | 6 | ChEMBL | 289 | 9 | 1 | 2 | 4.9 | CCCCCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
145967904 | 165192 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -5 | 6 | ChEMBL | 247 | 6 | 1 | 2 | 3.8 | CCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4227192 | 165192 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -5 | 6 | ChEMBL | 247 | 6 | 1 | 2 | 3.8 | CCCCCCN1CCC(c2cccc(O)c2)C1 | 10.1016/j.bmcl.2018.03.084 | |||
56594402 | 70623 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 334 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1C(=O)O | 10.1021/jm200676f | |||
CHEMBL1949727 | 70623 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 334 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1C(=O)O | 10.1021/jm200676f | |||
70607606 | 177309 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -2 | 2 | ChEMBL | 333 | 1 | 3 | 3 | 3.1 | Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4635277 | 177309 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -2 | 2 | ChEMBL | 333 | 1 | 3 | 3 | 3.1 | Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
11247757 | 133648 | None | 0 | Rat | Binding | pKi | = | 5.2 | 5.2 | -741 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | |||
CHEMBL371200 | 133648 | None | 0 | Rat | Binding | pKi | = | 5.2 | 5.2 | -741 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1CC[C@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 | 10.1021/jm049031l | |||
17756213 | 149792 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -1 | 5 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm070388+ | |||
CHEMBL394779 | 149792 | None | 0 | Human | Binding | pKi | = | 7.2 | 7.2 | -1 | 5 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2cc(O)ccc2CC1 | 10.1021/jm070388+ | |||
44415672 | 80205 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 6 | ChEMBL | 531 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL213492 | 80205 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 6 | ChEMBL | 531 | 2 | 1 | 5 | 5.6 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
46231768 | 201936 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 3 | ChEMBL | 328 | 0 | 2 | 3 | 3.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL591685 | 201936 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -2 | 3 | ChEMBL | 328 | 0 | 2 | 3 | 3.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
25142456 | 82438 | None | 1 | Human | Binding | pKi | = | 8.2 | 8.2 | -3 | 9 | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | |||
CHEMBL217299 | 82438 | None | 1 | Human | Binding | pKi | = | 8.2 | 8.2 | -3 | 9 | ChEMBL | 269 | 0 | 3 | 4 | 2.1 | Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2 | 10.1021/jm0604979 | |||
11223303 | 203286 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | ChEMBL | 399 | 2 | 3 | 3 | 4.1 | CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL600987 | 203286 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 3 | ChEMBL | 399 | 2 | 3 | 3 | 4.1 | CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C | 10.1016/j.bmcl.2009.12.100 | |||
46231847 | 203030 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 4 | ChEMBL | 343 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL599116 | 203030 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 4 | ChEMBL | 343 | 1 | 2 | 3 | 3.5 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
4350931 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm051237e | |||
CHEMBL441618 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm051237e | |||
4350931 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1039/C5MD00258C | |||
CHEMBL441618 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1039/C5MD00258C | |||
4350931 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
CHEMBL441618 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1016/j.bmcl.2006.11.093 | |||
4350931 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
CHEMBL441618 | 169416 | None | 30 | Human | Binding | pKi | = | 8.1 | 8.1 | -123 | 7 | ChEMBL | 290 | 0 | 1 | 1 | 3.8 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | 10.1021/jm060213k | |||
46231845 | 203189 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -2 | 4 | ChEMBL | 391 | 0 | 1 | 2 | 4.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL600083 | 203189 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -2 | 4 | ChEMBL | 391 | 0 | 1 | 2 | 4.7 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
122177645 | 121277 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -3311 | 6 | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | |||
CHEMBL3577346 | 121277 | None | 0 | Human | Binding | pKi | = | 6.2 | 6.2 | -3311 | 6 | ChEMBL | 591 | 18 | 2 | 8 | 5.6 | CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1 | 10.1021/jm501889t | |||
122181330 | 121937 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -8128 | 6 | ChEMBL | 396 | 9 | 1 | 3 | 5.3 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
CHEMBL3590081 | 121937 | None | 0 | Human | Binding | pKi | = | 5.2 | 5.2 | -8128 | 6 | ChEMBL | 396 | 9 | 1 | 3 | 5.3 | CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1 | 10.1016/j.bmc.2014.12.012 | |||
22475020 | 96056 | None | 19 | Human | Binding | pKi | = | 6.2 | 6.2 | -234 | 8 | ChEMBL | 491 | 3 | 0 | 4 | 5.4 | O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 | 10.6019/CHEMBL5442175 | |||
CHEMBL259656 | 96056 | None | 19 | Human | Binding | pKi | = | 6.2 | 6.2 | -234 | 8 | ChEMBL | 491 | 3 | 0 | 4 | 5.4 | O=C(c1cc2c(cc1F)OC(c1ccc(F)cc1)(c1ccc(Cl)cc1Cl)O2)N1CCOCC1 | 10.6019/CHEMBL5442175 | |||
11301268 | 13980 | None | 0 | Human | Binding | pKi | = | 4.2 | 4.2 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196825 | 13980 | None | 0 | Human | Binding | pKi | = | 4.2 | 4.2 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL558364 | 13980 | None | 0 | Human | Binding | pKi | = | 4.2 | 4.2 | - | 1 | ChEMBL | 271 | 3 | 1 | 2 | 3.1 | CN[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11290688 | 13949 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196599 | 13949 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL557582 | 13949 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
16007117 | 80067 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -72 | 6 | ChEMBL | 479 | 2 | 1 | 5 | 5.1 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
CHEMBL212912 | 80067 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -72 | 6 | ChEMBL | 479 | 2 | 1 | 5 | 5.1 | CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1 | 10.1016/j.bmcl.2006.06.022 | |||
44582676 | 189888 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -57 | 17 | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
CHEMBL516088 | 189888 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -57 | 17 | ChEMBL | 403 | 9 | 0 | 4 | 4.3 | COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
44582675 | 189810 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -125 | 15 | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
CHEMBL515472 | 189810 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -125 | 15 | ChEMBL | 405 | 9 | 1 | 4 | 4.2 | COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1 | 10.1016/j.bmc.2009.03.021 | |||
145980271 | 166587 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -1 | 16 | ChEMBL | 538 | 8 | 1 | 3 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
CHEMBL4278465 | 166587 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -1 | 16 | ChEMBL | 538 | 8 | 1 | 3 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2018.10.036 | |||
17756212 | 86402 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | |||
CHEMBL231374 | 86402 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | 1 | 5 | ChEMBL | 295 | 1 | 0 | 2 | 3.7 | COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2 | 10.1021/jm070388+ | |||
42626289 | 148167 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -3 | 4 | ChEMBL | 379 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL393492 | 148167 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -3 | 4 | ChEMBL | 379 | 7 | 0 | 4 | 3.3 | COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 | 10.1016/j.bmc.2007.06.002 | |||
11442138 | 69211 | None | 0 | Rat | Binding | pKi | = | 5.1 | 5.1 | -1862 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | |||
CHEMBL192650 | 69211 | None | 0 | Rat | Binding | pKi | = | 5.1 | 5.1 | -1862 | 3 | ChEMBL | 443 | 7 | 1 | 4 | 4.5 | COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 | 10.1021/jm049031l | |||
11415988 | 13973 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 | 10.1021/jm040889k | |||
CHEMBL1196757 | 13973 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 | 10.1021/jm040889k | |||
CHEMBL558040 | 13973 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 285 | 3 | 0 | 2 | 3.5 | COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N(C)C)C2 | 10.1021/jm040889k | |||
137651322 | 157567 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -8709 | 6 | ChEMBL | 465 | 8 | 2 | 9 | 2.2 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | |||
CHEMBL4079375 | 157567 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | -8709 | 6 | ChEMBL | 465 | 8 | 2 | 9 | 2.2 | O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12 | 10.1016/j.bmc.2017.08.037 | |||
11405458 | 12773 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1187931 | 12773 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL534478 | 12773 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 271 | 2 | 1 | 2 | 3.2 | CN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
154706461 | 176453 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -331 | 5 | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4470439 | 176453 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -331 | 5 | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595600 | 176453 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -331 | 5 | ChEMBL | 509 | 12 | 1 | 3 | 6.8 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 6.1 | 6.1 | -89 | 91 | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1021/jm9601720 | |||
154706431 | 176690 | None | 1 | Human | Binding | pKi | = | 6.1 | 6.1 | -70 | 6 | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4531363 | 176690 | None | 1 | Human | Binding | pKi | = | 6.1 | 6.1 | -70 | 6 | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4597531 | 176690 | None | 1 | Human | Binding | pKi | = | 6.1 | 6.1 | -70 | 6 | ChEMBL | 451 | 12 | 2 | 3 | 5.3 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC | 10.1021/acs.jmedchem.9b01835 | |||
11637457 | 73112 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -1 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | |||
CHEMBL201093 | 73112 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -1 | 5 | ChEMBL | 257 | 0 | 0 | 2 | 3.4 | CN1CCc2ccccc2Cc2ccsc2CC1 | 10.1021/jm050846j | |||
11154555 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
11154555.0 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
5037 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
7671 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL2028019 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
CHEMBL3085826 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
DB06016 | 800 | None | 50 | Human | Binding | pKi | = | 5.1 | 5.1 | -724 | 24 | ChEMBL | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1016/j.bmc.2017.04.036 | |||
9801858 | 63466 | None | 0 | Rat | Binding | pKi | = | 6.1 | 6.1 | -12 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
CHEMBL179757 | 63466 | None | 0 | Rat | Binding | pKi | = | 6.1 | 6.1 | -12 | 3 | ChEMBL | 413 | 6 | 1 | 3 | 4.5 | O=C(NCCCCN1CCN2c3ccccc3CCC2C1)c1ccc2ccccc2c1 | 10.1021/jm049031l | |||
3036864 | 205211 | None | 16 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm040889k | |||
CHEMBL1256645 | 205211 | None | 16 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm040889k | |||
CHEMBL1814790 | 205211 | None | 16 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm040889k | |||
CHEMBL62 | 205211 | None | 16 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 27 | ChEMBL | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | 10.1021/jm040889k | |||
46231646 | 202921 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 328 | 0 | 2 | 3 | 3.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
CHEMBL598515 | 202921 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 328 | 0 | 2 | 3 | 3.6 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.100 | |||
42625354 | 91634 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -2 | 4 | ChEMBL | 349 | 6 | 0 | 3 | 3.2 | O=C1c2ccccc2CN1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL240774 | 91634 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -2 | 4 | ChEMBL | 349 | 6 | 0 | 3 | 3.2 | O=C1c2ccccc2CN1CCCCN1CCN(c2ccccc2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
44436308 | 91793 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 3 | ChEMBL | 417 | 6 | 0 | 3 | 4.3 | O=C1c2ccccc2CN1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
CHEMBL240996 | 91793 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 3 | ChEMBL | 417 | 6 | 0 | 3 | 4.3 | O=C1c2ccccc2CN1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 | 10.1016/j.bmc.2007.06.002 | |||
154705038 | 176751 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -245 | 5 | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4584481 | 176751 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -245 | 5 | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4598001 | 176751 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -245 | 5 | ChEMBL | 471 | 11 | 2 | 2 | 6.2 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
130442480 | 175374 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | 1 | 24 | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
CHEMBL4572614 | 175374 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | 1 | 24 | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
156011458 | 177409 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 347 | 2 | 2 | 3 | 3.4 | COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
CHEMBL4636741 | 177409 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -1 | 2 | ChEMBL | 347 | 2 | 2 | 3 | 3.4 | COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2 | 10.1016/j.bmcl.2020.127305 | |||
11290269 | 13766 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1195331 | 13766 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL554303 | 13766 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11153135 | 12821 | None | 0 | Human | Binding | pKi | = | 4.1 | 4.1 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188308 | 12821 | None | 0 | Human | Binding | pKi | = | 4.1 | 4.1 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL536044 | 12821 | None | 0 | Human | Binding | pKi | = | 4.1 | 4.1 | - | 1 | ChEMBL | 341 | 7 | 0 | 2 | 5.0 | CCCN(CCC)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
71062708 | 154395 | None | 0 | Mouse | Binding | pKi | = | 5.1 | 5.1 | -48 | 12 | ChEMBL | 368 | 7 | 0 | 5 | 2.8 | COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | |||
CHEMBL3986651 | 154395 | None | 0 | Mouse | Binding | pKi | = | 5.1 | 5.1 | -48 | 12 | ChEMBL | 368 | 7 | 0 | 5 | 2.8 | COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 | nan | |||
57398351 | 70182 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -91 | 7 | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
CHEMBL1940406 | 70182 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -91 | 7 | ChEMBL | 347 | 6 | 0 | 2 | 5.1 | Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmc.2014.04.026 | |||
154725001 | 176752 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -562 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4525624 | 176752 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -562 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4598002 | 176752 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -562 | 6 | ChEMBL | 448 | 11 | 1 | 2 | 6.5 | CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.9b01835 | |||
154724650 | 176442 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -501 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4543870 | 176442 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -501 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595492 | 176442 | None | 1 | Human | Binding | pKi | = | 5.1 | 5.1 | -501 | 5 | ChEMBL | 475 | 12 | 1 | 3 | 6.4 | CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
11439190 | 203762 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -31 | 4 | ChEMBL | 338 | 0 | 1 | 3 | 3.9 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
CHEMBL604127 | 203762 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | -31 | 4 | ChEMBL | 338 | 0 | 1 | 3 | 3.9 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21 | 10.1016/j.bmcl.2009.12.094 | |||
11631304 | 73401 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 330 | 2 | 1 | 1 | 4.6 | c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2 | 10.1021/jm050846j | |||
CHEMBL201432 | 73401 | None | 0 | Human | Binding | pKi | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 330 | 2 | 1 | 1 | 4.6 | c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2 | 10.1021/jm050846j | |||
11976 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | |||
667467 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | |||
667467.0 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL908 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | |||
DB01239 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | ChEMBL | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | 10.1016/j.bmcl.2008.09.012 | |||
440229 | 87545 | None | 34 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 5 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
CHEMBL2334891 | 87545 | None | 34 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 5 | ChEMBL | 341 | 3 | 1 | 5 | 3.1 | COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2 | 10.1016/j.bmcl.2017.01.090 | |||
17755867 | 86143 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 6 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | |||
CHEMBL231070 | 86143 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 6 | ChEMBL | 281 | 0 | 1 | 2 | 3.4 | CN1CCCc2ccccc2Cc2ccc(O)cc2CC1 | 10.1021/jm070388+ | |||
135398745 | 2914 | None | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | |||
47 | 2914 | None | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | |||
DB00334 | 2914 | None | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | ChEMBL | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 10.1039/C5MD00258C | |||
11221294 | 12784 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1187988 | 12784 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL534706 | 12784 | None | 0 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 297 | 4 | 1 | 2 | 3.7 | C=CCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
182600 | 118808 | None | 1 | Rat | Binding | pKi | = | 6.0 | 6.0 | -10 | 4 | ChEMBL | 352 | 5 | 0 | 3 | 3.9 | O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 | 10.1021/jm049031l | |||
CHEMBL341774 | 118808 | None | 1 | Rat | Binding | pKi | = | 6.0 | 6.0 | -10 | 4 | ChEMBL | 352 | 5 | 0 | 3 | 3.9 | O=C(CCCN1CCN2c3ccccc3CCC2C1)c1ccc(F)cc1 | 10.1021/jm049031l | |||
56589561 | 70625 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 5 | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO | 10.1021/jm200676f | |||
CHEMBL1949729 | 70625 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | 1 | 5 | ChEMBL | 320 | 1 | 2 | 2 | 3.2 | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO | 10.1021/jm200676f | |||
16090821 | 81864 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -21 | 6 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | |||
CHEMBL216439 | 81864 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -21 | 6 | ChEMBL | 304 | 0 | 1 | 1 | 4.2 | CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 | 10.1021/jm060213k | |||
135986088 | 178220 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -275 | 6 | ChEMBL | 543 | 7 | 1 | 6 | 6.5 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 | 10.1016/j.bmcl.2008.09.012 | |||
CHEMBL464811 | 178220 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -275 | 6 | ChEMBL | 543 | 7 | 1 | 6 | 6.5 | Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2 | 10.1016/j.bmcl.2008.09.012 | |||
154727713 | 176469 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -10 | 5 | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4514586 | 176469 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -10 | 5 | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4595727 | 176469 | None | 1 | Human | Binding | pKi | = | 6.0 | 6.0 | -10 | 5 | ChEMBL | 426 | 10 | 1 | 6 | 4.5 | COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C | 10.1021/acs.jmedchem.9b01835 | |||
154725277 | 176537 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -363 | 6 | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4472900 | 176537 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -363 | 6 | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
CHEMBL4596220 | 176537 | None | 1 | Human | Binding | pKi | = | 5.0 | 5.0 | -363 | 6 | ChEMBL | 437 | 11 | 2 | 2 | 5.8 | CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.9b01835 | |||
137645574 | 157895 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -9999 | 6 | ChEMBL | 462 | 7 | 3 | 6 | 3.1 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
CHEMBL4083239 | 157895 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -9999 | 6 | ChEMBL | 462 | 7 | 3 | 6 | 3.1 | O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1 | 10.1021/acs.jmedchem.7b00363 | |||
11698643 | 3630 | None | 12 | Human | Binding | pKi | = | 6.0 | 6.0 | -181 | 4 | ChEMBL | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 10.1016/j.bmcl.2006.05.025 | |||
6125 | 3630 | None | 12 | Human | Binding | pKi | = | 6.0 | 6.0 | -181 | 4 | ChEMBL | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 10.1016/j.bmcl.2006.05.025 | |||
CHEMBL209497 | 3630 | None | 12 | Human | Binding | pKi | = | 6.0 | 6.0 | -181 | 4 | ChEMBL | 479 | 6 | 0 | 4 | 6.0 | O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1cccc(c1)OCCN1CCCC1)cccc2 | 10.1016/j.bmcl.2006.05.025 | |||
17755868 | 143205 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 5 | ChEMBL | 295 | 0 | 1 | 2 | 3.8 | CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 | 10.1021/jm070388+ | |||
CHEMBL389559 | 143205 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 5 | ChEMBL | 295 | 0 | 1 | 2 | 3.8 | CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1 | 10.1021/jm070388+ | |||
44396235 | 168640 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -60 | 5 | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/jm049720x | |||
CHEMBL435505 | 168640 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -60 | 5 | ChEMBL | 281 | 6 | 0 | 2 | 3.8 | c1ccc(Cc2ccccc2OCCN2CCCC2)cc1 | 10.1021/jm049720x | |||
145968810 | 165133 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -33 | 6 | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | |||
CHEMBL4226226 | 165133 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -33 | 6 | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1 | 10.1016/j.bmcl.2018.03.084 | |||
11450584 | 12804 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1188142 | 12804 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL535374 | 12804 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 257 | 2 | 2 | 2 | 2.8 | CN[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
11151473 | 13936 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL1196485 | 13936 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
CHEMBL557171 | 13936 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | - | 1 | ChEMBL | 243 | 1 | 2 | 2 | 2.5 | N[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 | 10.1021/jm040889k | |||
76328715 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115582 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139265 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
49783209 | 17616 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -489 | 26 | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
CHEMBL1258223 | 17616 | None | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -489 | 26 | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
76328715 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3115582 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
CHEMBL3139265 | 106428 | None | 0 | Human | Binding | pKi | = | 5.0 | 5.0 | -1047 | 4 | ChEMBL | 429 | 9 | 2 | 6 | 2.8 | Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(OCCF)cc3)CC1)CC2 | 10.1021/jm401384w | |||
52936725 | 61270 | None | 22 | Human | Binding | pKi | = | 6 | 6.0 | -39810 | 13 | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442175 | |||
CHEMBL1766103 | 61270 | None | 22 | Human | Binding | pKi | = | 6 | 6.0 | -39810 | 13 | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442175 | |||
5018 | 3549 | None | 8 | Human | Binding | pKd | = | 9.2 | 9.2 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 8051291 | |||
943 | 3549 | None | 8 | Human | Binding | pKd | = | 9.2 | 9.2 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 8051291 | |||
946 | 3549 | None | 8 | Human | Binding | pKd | = | 9.2 | 9.2 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 8051291 | |||
CHEMBL13668 | 3549 | None | 8 | Human | Binding | pKd | = | 9.2 | 9.2 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 8051291 | |||
3036864 | 205211 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1256645 | 205211 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1814790 | 205211 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL62 | 205211 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 9.5 | 9.5 | -3 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
1243 | 3618 | 3H-SCH23390 | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | PDSP KiDatabase | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | None | |||
944 | 3618 | 3H-SCH23390 | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | PDSP KiDatabase | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | None | |||
CHEMBL324017 | 3618 | 3H-SCH23390 | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | PDSP KiDatabase | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | None | |||
3036864 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1256645 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1814790 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL62 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9.3 | 9.3 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
3036864 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1256645 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL1814790 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
CHEMBL62 | 205211 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 9 | 9.0 | -2 | 27 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | None | |||
1242 | 3613 | 3H-SCH23390 | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
935 | 3613 | 3H-SCH23390 | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
CHEMBL286080 | 3613 | 3H-SCH23390 | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
24840389 | 115277 | 3H-SCH23390 | 5 | Human | Binding | pKi | = | 6 | 6.0 | -741 | 15 | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | |||
CHEMBL334529 | 115277 | 3H-SCH23390 | 5 | Human | Binding | pKi | = | 6 | 6.0 | -741 | 15 | PDSP KiDatabase | 415 | 9 | 0 | 4 | 4.6 | CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 | None | |||
44591012 | 175684 | UNDEFINED | 0 | Human | Binding | pKi | = | 6 | 6.0 | -204 | 6 | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL457957 | 175684 | UNDEFINED | 0 | Human | Binding | pKi | = | 6 | 6.0 | -204 | 6 | PDSP KiDatabase | 522 | 10 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
44591098 | 176867 | UNDEFINED | 0 | Human | Binding | pKi | = | 6 | 6.0 | -288 | 6 | PDSP KiDatabase | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL460402 | 176867 | UNDEFINED | 0 | Human | Binding | pKi | = | 6 | 6.0 | -288 | 6 | PDSP KiDatabase | 508 | 9 | 0 | 3 | 6.6 | CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1 | None | |||
3075702 | 219818 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6 | 6.0 | -2 | 37 | PDSP KiDatabase | 198 | 3 | 1 | 3 | 1.5 | C1CNC1COC2=CN=C(C=C2)Cl | None | |||
179 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
2159 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
2159.0 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
963 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
CHEMBL243712 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
DB06288 | 400 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 5 | 5.0 | -4365 | 50 | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
119192 | 2481 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -2818 | 9 | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | |||
1582 | 2481 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -2818 | 9 | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | |||
CHEMBL506981 | 2481 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -2818 | 9 | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | |||
DB06455 | 2481 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -2818 | 9 | PDSP KiDatabase | 586 | 7 | 2 | 7 | 5.8 | COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC | None | |||
134 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
1775 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
9681 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
9681.0 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
CHEMBL1065 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
DB00247 | 2514 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -8511 | 67 | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
484 | 2858 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -112 | 35 | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
951 | 2858 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -112 | 35 | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
CHEMBL432 | 2858 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -112 | 35 | PDSP KiDatabase | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | None | |||
15897 | 2862 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -354 | 36 | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
215 | 2862 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -354 | 36 | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
CHEMBL1979333 | 2862 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -354 | 36 | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
163839 | 2955 | 3H-SCH23390 | 0 | Rat | Binding | pKi | = | 5 | 5.0 | -562 | 7 | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | |||
268 | 2955 | 3H-SCH23390 | 0 | Rat | Binding | pKi | = | 5 | 5.0 | -562 | 7 | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | |||
CHEMBL55171 | 2955 | 3H-SCH23390 | 0 | Rat | Binding | pKi | = | 5 | 5.0 | -562 | 7 | PDSP KiDatabase | 391 | 6 | 1 | 4 | 3.7 | Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2 | None | |||
2202 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
4850 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
4850.0 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
49 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
CHEMBL1371770 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
DB12478 | 3132 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -316 | 21 | PDSP KiDatabase | 298 | 3 | 0 | 6 | 1.5 | c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 | None | |||
119570 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
119570.0 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
2233 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
953 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
CHEMBL301265 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
DB00413 | 3159 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -7585 | 40 | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
2 | 3261 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -2089 | 28 | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
54562 | 3261 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -2089 | 28 | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
CHEMBL240773 | 3261 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -2089 | 28 | PDSP KiDatabase | 219 | 2 | 1 | 2 | 2.0 | CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 | None | |||
2402 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
5095 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
5095.0 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
7295 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
CHEMBL589 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
DB00268 | 3370 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5 | 5.0 | -81 | 25 | PDSP KiDatabase | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
128563 | 3464 | 3H-SCH23390 | 24 | Human | Binding | pKi | = | 5 | 5.0 | -2344 | 41 | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
1666 | 3464 | 3H-SCH23390 | 24 | Human | Binding | pKi | = | 5 | 5.0 | -2344 | 41 | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
CHEMBL445332 | 3464 | 3H-SCH23390 | 24 | Human | Binding | pKi | = | 5 | 5.0 | -2344 | 41 | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
DB12327 | 3464 | 3H-SCH23390 | 24 | Human | Binding | pKi | = | 5 | 5.0 | -2344 | 41 | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
213 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
2717 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
5533 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
5533.0 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
CHEMBL621 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
DB00656 | 3853 | 3H-SCH23390 | 34 | Human | Binding | pKi | = | 5 | 5.0 | -549 | 43 | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
185 | 4006 | 3H-SCH23390 | 43 | Human | Binding | pKi | = | 5 | 5.0 | -29512 | 37 | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
5311271 | 4006 | 3H-SCH23390 | 43 | Human | Binding | pKi | = | 5 | 5.0 | -29512 | 37 | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
CHEMBL74355 | 4006 | 3H-SCH23390 | 43 | Human | Binding | pKi | = | 5 | 5.0 | -29512 | 37 | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
DB16351 | 4006 | 3H-SCH23390 | 43 | Human | Binding | pKi | = | 5 | 5.0 | -29512 | 37 | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
2662 | 11388 | 3H-SCH23390 | 77 | Human | Binding | pKi | = | 5 | 5.0 | -41 | 31 | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
CHEMBL118 | 11388 | 3H-SCH23390 | 77 | Human | Binding | pKi | = | 5 | 5.0 | -41 | 31 | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
5090 | 15568 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 5 | 5.0 | -1348 | 31 | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
CHEMBL122 | 15568 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 5 | 5.0 | -1348 | 31 | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
10297 | 27120 | 3H-SCH23390 | 13 | Human | Binding | pKi | = | 5 | 5.0 | -38 | 42 | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
CHEMBL136560 | 27120 | 3H-SCH23390 | 13 | Human | Binding | pKi | = | 5 | 5.0 | -38 | 42 | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
156391 | 46814 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
CHEMBL1200806 | 46814 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
CHEMBL154 | 46814 | 3H-SCH23390 | 58 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
10624 | 70324 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -102 | 32 | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
10624.0 | 70324 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -102 | 32 | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
138543650 | 70324 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -102 | 32 | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
CHEMBL194378 | 70324 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -102 | 32 | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
DB11664 | 70324 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -102 | 32 | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
2244 | 94286 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | |||
CHEMBL25 | 94286 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 180 | 2 | 1 | 3 | 1.3 | CC(=O)Oc1ccccc1C(=O)O | None | |||
7153 | 98073 | 3H-SCH23390 | 55 | Human | Binding | pKi | = | 5 | 5.0 | -524 | 33 | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
CHEMBL272942 | 98073 | 3H-SCH23390 | 55 | Human | Binding | pKi | = | 5 | 5.0 | -524 | 33 | PDSP KiDatabase | 214 | 3 | 1 | 2 | 2.5 | Cc1cc(Cl)ccc1OC(C)C(=O)O | None | |||
3663 | 100021 | 3H-SCH23390 | 53 | Human | Binding | pKi | = | 5 | 5.0 | -288 | 29 | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | |||
CHEMBL286494 | 100021 | 3H-SCH23390 | 53 | Human | Binding | pKi | = | 5 | 5.0 | -288 | 29 | PDSP KiDatabase | 504 | 0 | 6 | 8 | 5.1 | Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 | None | |||
446220 | 133590 | 3H-SCH23390 | 7 | Human | Binding | pKi | = | 5 | 5.0 | -1778 | 45 | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
CHEMBL370805 | 133590 | 3H-SCH23390 | 7 | Human | Binding | pKi | = | 5 | 5.0 | -1778 | 45 | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
1615 | 167894 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -26 | 44 | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
CHEMBL43048 | 167894 | 3H-SCH23390 | 12 | Human | Binding | pKi | = | 5 | 5.0 | -26 | 44 | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
5280343 | 188382 | 3H-SCH23390 | 69 | Human | Binding | pKi | = | 5 | 5.0 | -147 | 32 | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
CHEMBL1520590 | 188382 | 3H-SCH23390 | 69 | Human | Binding | pKi | = | 5 | 5.0 | -147 | 32 | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
CHEMBL50 | 188382 | 3H-SCH23390 | 69 | Human | Binding | pKi | = | 5 | 5.0 | -147 | 32 | PDSP KiDatabase | 302 | 1 | 5 | 7 | 2.0 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | None | |||
3672 | 192642 | 3H-SCH23390 | 78 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
CHEMBL521 | 192642 | 3H-SCH23390 | 78 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
54676228 | 193723 | 3H-SCH23390 | 67 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
CHEMBL527 | 193723 | 3H-SCH23390 | 67 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
4495 | 198991 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
CHEMBL56367 | 198991 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
54677470 | 203007 | 3H-SCH23390 | 67 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
CHEMBL1256873 | 203007 | 3H-SCH23390 | 67 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
CHEMBL599 | 203007 | 3H-SCH23390 | 67 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
162265 | 204731 | 3H-SCH23390 | 11 | Human | Binding | pKi | = | 5 | 5.0 | -1949 | 44 | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
4786 | 204731 | 3H-SCH23390 | 11 | Human | Binding | pKi | = | 5 | 5.0 | -1949 | 44 | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
CHEMBL61006 | 204731 | 3H-SCH23390 | 11 | Human | Binding | pKi | = | 5 | 5.0 | -1949 | 44 | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
5281600 | 205483 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -275 | 33 | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
CHEMBL63354 | 205483 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 5 | 5.0 | -275 | 33 | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
1973 | 205941 | 3H-SCH23390 | 12 | Rat | Binding | pKi | = | 5 | 5.0 | -3 | 36 | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
CHEMBL1394464 | 205941 | 3H-SCH23390 | 12 | Rat | Binding | pKi | = | 5 | 5.0 | -3 | 36 | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
CHEMBL66089 | 205941 | 3H-SCH23390 | 12 | Rat | Binding | pKi | = | 5 | 5.0 | -3 | 36 | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
202478 | 207145 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -97 | 25 | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
CHEMBL7393 | 207145 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 5 | 5.0 | -97 | 25 | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
3821 | 207176 | 3H-SCH23390 | 11 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 18 | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
CHEMBL742 | 207176 | 3H-SCH23390 | 11 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 18 | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
4054 | 207959 | 3H-SCH23390 | 46 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 37 | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
CHEMBL1699 | 207959 | 3H-SCH23390 | 46 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 37 | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
CHEMBL807 | 207959 | 3H-SCH23390 | 46 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 37 | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
119607 | 208661 | 3H-SCH23390 | 64 | Human | Binding | pKi | = | 5 | 5.0 | -97 | 28 | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
CHEMBL865 | 208661 | 3H-SCH23390 | 64 | Human | Binding | pKi | = | 5 | 5.0 | -97 | 28 | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
3337 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
3337.0 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
65801 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
66264 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
91452 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
CHEMBL87493 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
DB00574 | 208825 | 3H-SCH23390 | 14 | Human | Binding | pKi | = | 5 | 5.0 | -1513 | 40 | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
164512405 | 218439 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -457 | 12 | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
5355 | 218439 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -457 | 12 | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
5355.0 | 218439 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -457 | 12 | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
CHEMBL26 | 218439 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -457 | 12 | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
DB00391 | 218439 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -457 | 12 | PDSP KiDatabase | 341 | 6 | 2 | 5 | 0.6 | CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC | None | |||
44134711 | 218481 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -112201 | 13 | PDSP KiDatabase | 340 | 6 | 2 | 4 | 2.8 | CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl | None | |||
None | 218483 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 27 | PDSP KiDatabase | 329 | 2 | 0 | 4 | 3.6 | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl | None | |||
104911 | 218509 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -41686 | 37 | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | |||
25137849 | 218667 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -4 | 40 | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
71290 | 218667 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -4 | 40 | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
None | 218721 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -13 | 6 | PDSP KiDatabase | 255 | 2 | 1 | 2 | 2.4 | CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl | None | |||
None | 218726 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -95499 | 29 | PDSP KiDatabase | 316 | 7 | 3 | 3 | 3.0 | CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O | None | |||
None | 218798 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 33 | PDSP KiDatabase | 240 | 7 | 4 | 6 | -0.8 | C(C(C(=O)O)N)SSCC(C(=O)O)N | None | |||
None | 218799 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 33 | PDSP KiDatabase | 149 | 4 | 2 | 3 | 0.2 | CSCCC(C(=O)O)N | None | |||
None | 218800 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 33 | PDSP KiDatabase | 135 | 3 | 3 | 3 | -0.3 | C(CS)C(C(=O)O)N | None | |||
None | 218801 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 33 | PDSP KiDatabase | 121 | 2 | 3 | 3 | -0.7 | C(C(C(=O)O)N)S | None | |||
None | 218802 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 117 | 0 | 1 | 3 | -0.0 | C1CSC(=O)C1N | None | |||
None | 218803 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 39 | PDSP KiDatabase | 153 | 3 | 3 | 3 | -1.4 | C(C(C(=O)O)N)S(=O)O | None | |||
None | 218804 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 38 | PDSP KiDatabase | 169 | 3 | 3 | 4 | -1.7 | C(C(C(=O)O)N)S(=O)(=O)O | None | |||
None | 218805 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 29 | PDSP KiDatabase | 183 | 4 | 3 | 4 | -1.3 | C(CS(=O)(=O)O)C(C(=O)O)N | None | |||
None | 218812 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -13 | 40 | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.2 | CC(C(=O)C1=CC=CC=C1)N | None | |||
1576 | 218813 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -16 | 40 | PDSP KiDatabase | 163 | 3 | 1 | 2 | 1.5 | CC(C(=O)C1=CC=CC=C1)NC | None | |||
None | 218814 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -16 | 28 | PDSP KiDatabase | 536 | 11 | 1 | 4 | 9.0 | CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C | None | |||
4978 | 218815 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -16 | 28 | PDSP KiDatabase | 520 | 1 | 7 | 9 | 4.3 | CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O | None | |||
None | 218816 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -3 | 28 | PDSP KiDatabase | 464 | 4 | 8 | 12 | -0.6 | C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O | None | |||
None | 218817 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -281 | 28 | PDSP KiDatabase | 610 | 6 | 10 | 16 | -1.7 | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O | None | |||
None | 218818 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 448 | 3 | 7 | 11 | 0.4 | CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O | None | |||
None | 218829 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1862 | 19 | PDSP KiDatabase | 246 | 2 | 1 | 4 | 1.6 | CCCN1CCCC2C1CC3=CN=C(N=C3C2)N | None | |||
135269 | 218876 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 222 | 5 | 1 | 3 | 2.5 | CCCCC(=O)OC1=CC=CC=C1C(=O)O | None | |||
23681059 | 218877 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 29 | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O | None | |||
5018304 | 218878 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 29 | PDSP KiDatabase | 317 | 4 | 1 | 3 | 0.0 | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | None | |||
84003 | 218879 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 28 | PDSP KiDatabase | 376 | 6 | 5 | 7 | -0.0 | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O | None | |||
123619 | 218880 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1412 | 27 | PDSP KiDatabase | 358 | 3 | 0 | 4 | 4.2 | CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl | None | |||
119828 | 218881 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -1 | 30 | PDSP KiDatabase | 370 | 5 | 1 | 5 | 3.5 | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C | None | |||
None | 218882 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5 | 5.0 | -7 | 29 | PDSP KiDatabase | 517 | 8 | 2 | 5 | 5.2 | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C | None | |||
None | 218718 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | -281 | 2 | PDSP KiDatabase | 575 | 5 | 3 | 6 | 2.4 | CCC(C)C1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O | None | |||
30137 | 2877 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -3019 | 10 | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | |||
8594 | 2877 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -3019 | 10 | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | |||
934 | 2877 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 5.9 | 5.9 | -3019 | 10 | PDSP KiDatabase | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | None | |||
1212 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
204 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372.0 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL726 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00623 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
242 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
34 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795.0 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL1112 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
DB01238 | 470 | 3H-SCH23390 | 70 | Rat | Binding | pKi | = | 5.9 | 5.9 | -870 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
124936 | 220178 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | -6 | 7 | PDSP KiDatabase | 268 | 3 | 1 | 5 | 4.8 | CNC1=CC=C(C=C1)N=NC2=CC3=C(C=C2)N=CS3 | None | |||
2726 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2726.0 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
621 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
83 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
CHEMBL71 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
DB00477 | 919 | 3H-SCH23390 | 48 | Human | Binding | pKi | = | 6.9 | 6.9 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
1212 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
204 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372.0 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL726 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00623 | 1662 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 7.9 | 7.9 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
25058166 | 218450 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -37 | 26 | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
6852389 | 218450 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | -37 | 26 | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
1353 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559.0 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
86 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
CHEMBL54 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
DB00502 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
1153 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
12668023 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026874 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026875 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341.0 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
6603851 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
933 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
939 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
985 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1160786 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1161520 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL588 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
DB00800 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 7.8 | 7.8 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
2337 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
50 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002.0 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
CHEMBL716 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
DB01224 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
2865 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
59 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
60854 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
60854.0 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
CHEMBL708 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
DB00246 | 4143 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.8 | 6.8 | -64 | 53 | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
44591134 | 176304 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 6 | PDSP KiDatabase | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL459373 | 176304 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -125 | 6 | PDSP KiDatabase | 535 | 11 | 0 | 5 | 7.7 | CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
2389 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073.0 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
96 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
CHEMBL85 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
DB00734 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 7.8 | 7.8 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
6603820 | 95827 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 7.8 | 7.8 | -1 | 13 | PDSP KiDatabase | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | None | |||
CHEMBL25856 | 95827 | 3H-SCH23390 | 16 | Rat | Binding | pKi | = | 7.8 | 7.8 | -1 | 13 | PDSP KiDatabase | 267 | 0 | 3 | 3 | 2.6 | Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 | None | |||
242 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
34 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795.0 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL1112 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
DB01238 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.8 | 5.8 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
180 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
200 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
2160 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
2160.0 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
CHEMBL629 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
DB00321 | 401 | UNDEFINED | 38 | Human | Binding | pKi | = | 6.8 | 6.8 | -112 | 39 | PDSP KiDatabase | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
11954224 | 218443 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -478 | 59 | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
3251 | 218443 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -478 | 59 | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
3251.0 | 218443 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -478 | 59 | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
CHEMBL1982133 | 218443 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -478 | 59 | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
DB00696 | 218443 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.8 | 6.8 | -478 | 59 | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
2726 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2726.0 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
621 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
83 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
CHEMBL71 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
DB00477 | 919 | UNDEFINED | 48 | Human | Binding | pKi | = | 6.8 | 6.8 | -47 | 72 | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2337 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
50 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002.0 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
CHEMBL716 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
DB01224 | 3256 | 3H-SCH23390 | 51 | Human | Binding | pKi | = | 5.8 | 5.8 | -27 | 62 | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
1353 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559.0 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
86 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
CHEMBL54 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
DB00502 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 6.8 | 6.8 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
219050 | 3373 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 6.7 | 6.7 | -1174 | 21 | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | |||
52 | 3373 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 6.7 | 6.7 | -1174 | 21 | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | |||
CHEMBL431367 | 3373 | 3H-SCH23390 | 19 | Human | Binding | pKi | = | 6.7 | 6.7 | -1174 | 21 | PDSP KiDatabase | 346 | 6 | 2 | 2 | 5.0 | Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 | None | |||
135398737 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135398737.0 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
38 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
722 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
CHEMBL42 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
DB00363 | 958 | UNDEFINED | 57 | Human | Binding | pKi | = | 6.7 | 6.7 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
1212 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
204 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372.0 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL726 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00623 | 1662 | UNDEFINED | 37 | Human | Binding | pKi | = | 7.7 | 7.7 | -28 | 65 | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
100 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.7 | 6.7 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
2637 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.7 | 6.7 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
5452 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.7 | 6.7 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
CHEMBL479 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.7 | 6.7 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
DB00679 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.7 | 6.7 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
None | 218828 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 7.7 | 7.7 | -29 | 19 | PDSP KiDatabase | 451 | 8 | 2 | 4 | 3.2 | CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C | None | |||
3036780 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
3036780.0 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
46780481 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
9903970 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
9903970.0 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL3187365 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL3544974 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL504548 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
DB06216 | 107587 | 3H-SCH23390 | 16 | Human | Binding | pKi | = | 7.6 | 7.6 | -77 | 53 | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
681 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
681.0 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
940 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
947 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
CHEMBL59 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
DB00988 | 1465 | 3H-SCH23390 | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | PDSP KiDatabase | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
2601 | 3780 | 3H-SCH23390 | 25 | Human | Binding | pKi | = | 7.6 | 7.6 | -15 | 21 | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
443951 | 3780 | 3H-SCH23390 | 25 | Human | Binding | pKi | = | 7.6 | 7.6 | -15 | 21 | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
56 | 3780 | 3H-SCH23390 | 25 | Human | Binding | pKi | = | 7.6 | 7.6 | -15 | 21 | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL73151 | 3780 | 3H-SCH23390 | 25 | Human | Binding | pKi | = | 7.6 | 7.6 | -15 | 21 | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB13399 | 3780 | 3H-SCH23390 | 25 | Human | Binding | pKi | = | 7.6 | 7.6 | -15 | 21 | PDSP KiDatabase | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
135398737 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135398737.0 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
38 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
722 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
CHEMBL42 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
DB00363 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
5311189 | 207299 | 3H-SCH23390 | 9 | Human | Binding | pKi | = | 5.6 | 5.6 | -46 | 27 | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
CHEMBL7549 | 207299 | 3H-SCH23390 | 9 | Human | Binding | pKi | = | 5.6 | 5.6 | -46 | 27 | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
103 | 4153 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.6 | 6.6 | -33 | 53 | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2875 | 4153 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.6 | 6.6 | -33 | 53 | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
5736 | 4153 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.6 | 6.6 | -33 | 53 | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
CHEMBL285802 | 4153 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.6 | 6.6 | -33 | 53 | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
DB09225 | 4153 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.6 | 6.6 | -33 | 53 | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
135398737 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135398737.0 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
38 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
722 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
CHEMBL42 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
DB00363 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
1524 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
197 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
3822 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
3822.0 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
88 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
CHEMBL51 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
DB12465 | 2181 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 5.6 | 5.6 | -234 | 51 | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
242 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
34 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795.0 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL1112 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
DB01238 | 470 | 3H-SCH23390 | 70 | Human | Binding | pKi | = | 5.6 | 5.6 | -380 | 51 | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
11954259 | 218469 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -870 | 43 | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | |||
25212275 | 174525 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6309 | 6 | PDSP KiDatabase | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL455288 | 174525 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -6309 | 6 | PDSP KiDatabase | 682 | 13 | 0 | 8 | 7.4 | O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 | None | |||
25212276 | 190175 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -741 | 6 | PDSP KiDatabase | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL517244 | 190175 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -741 | 6 | PDSP KiDatabase | 508 | 11 | 0 | 3 | 7.4 | CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
37459 | 746 | 3H-SCH23390 | 9 | Human | Binding | pKi | = | 7.6 | 7.6 | -61 | 24 | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | |||
62 | 746 | 3H-SCH23390 | 9 | Human | Binding | pKi | = | 7.6 | 7.6 | -61 | 24 | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | |||
CHEMBL8514 | 746 | 3H-SCH23390 | 9 | Human | Binding | pKi | = | 7.6 | 7.6 | -61 | 24 | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | None | |||
44591099 | 176294 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -1023 | 6 | PDSP KiDatabase | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
CHEMBL459350 | 176294 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.6 | 6.6 | -1023 | 6 | PDSP KiDatabase | 494 | 10 | 0 | 3 | 7.0 | CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 | None | |||
135398737 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135398737.0 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
38 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
722 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
CHEMBL42 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
DB00363 | 958 | 3H-SCH23390 | 57 | Human | Binding | pKi | = | 6.6 | 6.6 | -89 | 91 | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135409468 | 2035 | 3H-SCH23390 | 50 | Human | Binding | pKi | = | 6.6 | 6.6 | -100 | 40 | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
333 | 2035 | 3H-SCH23390 | 50 | Human | Binding | pKi | = | 6.6 | 6.6 | -100 | 40 | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
CHEMBL845 | 2035 | 3H-SCH23390 | 50 | Human | Binding | pKi | = | 6.6 | 6.6 | -100 | 40 | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
186 | 1807 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5.5 | 5.5 | -380 | 16 | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
71781 | 1807 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5.5 | 5.5 | -380 | 16 | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
CHEMBL18972 | 1807 | 3H-SCH23390 | 38 | Human | Binding | pKi | = | 5.5 | 5.5 | -380 | 16 | PDSP KiDatabase | 295 | 5 | 1 | 2 | 3.7 | OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 | None | |||
115237 | 55601 | 3H-SCH23390 | 68 | Human | Binding | pKi | = | 7.5 | 7.5 | -11 | 54 | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
115237.0 | 55601 | 3H-SCH23390 | 68 | Human | Binding | pKi | = | 7.5 | 7.5 | -11 | 54 | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
CHEMBL1621 | 55601 | 3H-SCH23390 | 68 | Human | Binding | pKi | = | 7.5 | 7.5 | -11 | 54 | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
DB01267 | 55601 | 3H-SCH23390 | 68 | Human | Binding | pKi | = | 7.5 | 7.5 | -11 | 54 | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
None | 219647 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | -190 | 6 | PDSP KiDatabase | 532 | 10 | 0 | 4 | 8.0 | CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5 | None | |||
1588 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
28864 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
28864.0 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
43 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL157138 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB00589 | 2325 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.5 | 8.5 | -13 | 43 | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
100 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.5 | 6.5 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
2637 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.5 | 6.5 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
5452 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.5 | 6.5 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
CHEMBL479 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.5 | 6.5 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
DB00679 | 3805 | 3H-SCH23390 | 44 | Human | Binding | pKi | = | 6.5 | 6.5 | -85 | 55 | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
5 | 139 | 3H-SCH23390 | 45 | Human | Binding | pKi | = | 5.5 | 5.5 | -7244 | 54 | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
5202 | 139 | 3H-SCH23390 | 45 | Human | Binding | pKi | = | 5.5 | 5.5 | -7244 | 54 | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
CHEMBL39 | 139 | 3H-SCH23390 | 45 | Human | Binding | pKi | = | 5.5 | 5.5 | -7244 | 54 | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
DB08839 | 139 | 3H-SCH23390 | 45 | Human | Binding | pKi | = | 5.5 | 5.5 | -7244 | 54 | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
3294 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
71360 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
71360.0 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
87 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
CHEMBL14376 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
DB04946 | 2006 | 3H-SCH23390 | 61 | Human | Binding | pKi | = | 6.5 | 6.5 | -66 | 44 | PDSP KiDatabase | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
2105 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 7.5 | 7.5 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
47811 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 7.5 | 7.5 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
48 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 7.5 | 7.5 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
CHEMBL531 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 7.5 | 7.5 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
DB01186 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 7.5 | 7.5 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
1621 | 2429 | 3H-SCH23390 | 10 | Rat | Binding | pKi | = | 6.5 | 6.5 | -1096 | 44 | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
17 | 2429 | 3H-SCH23390 | 10 | Rat | Binding | pKi | = | 6.5 | 6.5 | -1096 | 44 | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
5761 | 2429 | 3H-SCH23390 | 10 | Rat | Binding | pKi | = | 6.5 | 6.5 | -1096 | 44 | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL263881 | 2429 | 3H-SCH23390 | 10 | Rat | Binding | pKi | = | 6.5 | 6.5 | -1096 | 44 | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB04829 | 2429 | 3H-SCH23390 | 10 | Rat | Binding | pKi | = | 6.5 | 6.5 | -1096 | 44 | PDSP KiDatabase | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
104870 | 98934 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 5.5 | 5.5 | -7 | 21 | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
5374 | 98934 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 5.5 | 5.5 | -7 | 21 | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
CHEMBL279085 | 98934 | 3H-SCH23390 | 37 | Human | Binding | pKi | = | 5.5 | 5.5 | -7 | 21 | PDSP KiDatabase | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
5018 | 3549 | 3H-SCH23390 | 8 | Human | Binding | pKi | = | 7.5 | 7.5 | -2 | 9 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | None | |||
943 | 3549 | 3H-SCH23390 | 8 | Human | Binding | pKi | = | 7.5 | 7.5 | -2 | 9 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | None | |||
946 | 3549 | 3H-SCH23390 | 8 | Human | Binding | pKi | = | 7.5 | 7.5 | -2 | 9 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | None | |||
CHEMBL13668 | 3549 | 3H-SCH23390 | 8 | Human | Binding | pKi | = | 7.5 | 7.5 | -2 | 9 | PDSP KiDatabase | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | None | |||
25058166 | 218450 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -37 | 26 | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
6852389 | 218450 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -37 | 26 | PDSP KiDatabase | 267 | 0 | 2 | 3 | 2.9 | CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O | None | |||
2402 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
5095 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
5095.0 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
7295 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
CHEMBL589 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
DB00268 | 3370 | None | 38 | Human | Binding | pKi | = | 8.4 | 8.4 | -81 | 25 | Drug Central | 260 | 7 | 1 | 2 | 3.5 | CCCN(CCC)CCc1cccc2c1CC(=N2)O | None | |||
6917970 | 3691 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
8370 | 3691 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
CHEMBL487387 | 3691 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 8.4 | 8.4 | 1 | 34 | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
4011 | 82440 | UNDEFINED | 34 | Human | Binding | pKi | = | 6.4 | 6.4 | -57 | 23 | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | |||
CHEMBL21731 | 82440 | UNDEFINED | 34 | Human | Binding | pKi | = | 6.4 | 6.4 | -57 | 23 | PDSP KiDatabase | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | |||
2470 | 3653 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 5.4 | 5.4 | -14791 | 59 | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
3300 | 3653 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 5.4 | 5.4 | -14791 | 59 | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
5265 | 3653 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 5.4 | 5.4 | -14791 | 59 | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
99 | 3653 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 5.4 | 5.4 | -14791 | 59 | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
CHEMBL267930 | 3653 | 3H-SCH23390 | 40 | Human | Binding | pKi | = | 5.4 | 5.4 | -14791 | 59 | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
31101 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
31101.0 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
35 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
403 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
CHEMBL493 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
DB01200 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
1353 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559.0 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
86 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
CHEMBL54 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
DB00502 | 1911 | 3H-SCH23390 | 63 | Human | Binding | pKi | = | 7.3 | 7.3 | -54 | 85 | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
11154555 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
11154555.0 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
5037 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
7671 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL2028019 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL3085826 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
DB06016 | 800 | None | 50 | Human | Binding | pKi | = | 8.3 | 8.3 | -724 | 24 | Drug Central | 426 | 5 | 1 | 3 | 4.3 | O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | = | 8.3 | 8.3 | -14791 | 59 | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | = | 8.3 | 8.3 | -14791 | 59 | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | = | 8.3 | 8.3 | -14791 | 59 | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
99 | 3653 | None | 40 | Human | Binding | pKi | = | 8.3 | 8.3 | -14791 | 59 | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | = | 8.3 | 8.3 | -14791 | 59 | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
104870 | 98934 | None | 37 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 21 | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
5374 | 98934 | None | 37 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 21 | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
CHEMBL279085 | 98934 | None | 37 | Human | Binding | pKi | = | 8.3 | 8.3 | -7 | 21 | Drug Central | 209 | 2 | 1 | 4 | 1.3 | C=CCN1CCc2nc(N)sc2CC1 | None | |||
1524 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
197 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
3822 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
3822.0 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
88 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
CHEMBL51 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
DB12465 | 2181 | None | 61 | Human | Binding | pKi | = | 8.3 | 8.3 | -234 | 51 | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
100 | 3805 | None | 44 | Human | Binding | pKi | = | 8.3 | 8.3 | -85 | 55 | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
2637 | 3805 | None | 44 | Human | Binding | pKi | = | 8.3 | 8.3 | -85 | 55 | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
5452 | 3805 | None | 44 | Human | Binding | pKi | = | 8.3 | 8.3 | -85 | 55 | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
CHEMBL479 | 3805 | None | 44 | Human | Binding | pKi | = | 8.3 | 8.3 | -85 | 55 | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
DB00679 | 3805 | None | 44 | Human | Binding | pKi | = | 8.3 | 8.3 | -85 | 55 | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
242 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
34 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
60795.0 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
CHEMBL1112 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
DB01238 | 470 | None | 70 | Human | Binding | pKi | = | 8.3 | 8.3 | -380 | 51 | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
2337 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
50 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
5002.0 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
CHEMBL716 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
DB01224 | 3256 | None | 51 | Human | Binding | pKi | = | 8.2 | 8.2 | -27 | 62 | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
31101 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
31101.0 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
35 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
403 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
CHEMBL493 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
DB01200 | 729 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.3 | 6.3 | -239 | 35 | PDSP KiDatabase | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
2389 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073.0 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
96 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
CHEMBL85 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
DB00734 | 3331 | 3H-SCH23390 | 72 | Human | Binding | pKi | = | 6.3 | 6.3 | -234 | 67 | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
2407 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
59227 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
59227.0 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
941 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
CHEMBL1303 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
DB05271 | 3372 | None | 50 | Human | Binding | pKi | = | 8.2 | 8.2 | -83 | 7 | Drug Central | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | None | |||
31101 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
31101.0 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
35 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
403 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
CHEMBL493 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
DB01200 | 729 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -239 | 35 | Drug Central | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | None | |||
4011 | 82440 | None | 34 | Human | Binding | pKi | = | 8.2 | 8.2 | -57 | 23 | Drug Central | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | |||
CHEMBL21731 | 82440 | None | 34 | Human | Binding | pKi | = | 8.2 | 8.2 | -57 | 23 | Drug Central | 277 | 4 | 1 | 1 | 4.2 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | None | |||
7077 | 66980 | None | 21 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 5 | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | |||
CHEMBL186720 | 66980 | None | 21 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 5 | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | |||
CHEMBL3925724 | 66980 | None | 21 | Human | Binding | pKi | = | 8.2 | 8.2 | -4 | 5 | Drug Central | 255 | 6 | 0 | 2 | 3.2 | CN(C)CCOc1ccccc1Cc1ccccc1 | None | |||
1621 | 2429 | None | 10 | Human | Binding | pKi | = | 8.2 | 8.2 | -151 | 44 | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
17 | 2429 | None | 10 | Human | Binding | pKi | = | 8.2 | 8.2 | -151 | 44 | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
5761 | 2429 | None | 10 | Human | Binding | pKi | = | 8.2 | 8.2 | -151 | 44 | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL263881 | 2429 | None | 10 | Human | Binding | pKi | = | 8.2 | 8.2 | -151 | 44 | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB04829 | 2429 | None | 10 | Human | Binding | pKi | = | 8.2 | 8.2 | -151 | 44 | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
3294 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
71360 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
71360.0 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
87 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
CHEMBL14376 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
DB04946 | 2006 | None | 61 | Human | Binding | pKi | = | 8.2 | 8.2 | -66 | 44 | Drug Central | 426 | 8 | 0 | 6 | 4.8 | COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C | None | |||
212 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
2639 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
941651 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
941651.0 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
CHEMBL1201 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
DB01623 | 3806 | None | 35 | Human | Binding | pKi | = | 8.2 | 8.2 | -6 | 25 | Drug Central | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C | None | |||
135398737 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
38 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
722 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | = | 8.2 | 8.2 | -89 | 91 | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
103 | 4153 | None | 44 | Human | Binding | pKi | = | 8.2 | 8.2 | -33 | 53 | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2875 | 4153 | None | 44 | Human | Binding | pKi | = | 8.2 | 8.2 | -33 | 53 | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
5736 | 4153 | None | 44 | Human | Binding | pKi | = | 8.2 | 8.2 | -33 | 53 | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
CHEMBL285802 | 4153 | None | 44 | Human | Binding | pKi | = | 8.2 | 8.2 | -33 | 53 | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
DB09225 | 4153 | None | 44 | Human | Binding | pKi | = | 8.2 | 8.2 | -33 | 53 | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2105 | 3054 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -125 | 33 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
47811 | 3054 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -125 | 33 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
48 | 3054 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -125 | 33 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
CHEMBL531 | 3054 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -125 | 33 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
DB01186 | 3054 | None | 28 | Human | Binding | pKi | = | 8.2 | 8.2 | -125 | 33 | Drug Central | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
180 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
200 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
2160 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
2160.0 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
CHEMBL629 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
DB00321 | 401 | None | 38 | Human | Binding | pKi | = | 8.2 | 8.2 | -112 | 39 | Drug Central | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | None | |||
2865 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
59 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
60854 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
60854.0 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
CHEMBL708 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
DB00246 | 4143 | None | 47 | Human | Binding | pKi | = | 8.2 | 8.2 | -64 | 53 | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
33630 | 179063 | None | 62 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 27 | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | |||
CHEMBL47050 | 179063 | None | 62 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 27 | Drug Central | 523 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | None | |||
2726 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
621 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
83 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | = | 8.2 | 8.2 | -47 | 72 | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
1153 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
12668023 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026874 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026875 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341.0 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
6603851 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
933 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
939 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
985 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1160786 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1161520 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL588 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
DB00800 | 1628 | None | 36 | Human | Binding | pKi | = | 8.2 | 8.2 | -22 | 10 | Drug Central | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
277 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
2913 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
2913.0 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
765 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
CHEMBL516 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
DB00434 | 1301 | 3H-SCH23390 | 39 | Human | Binding | pKi | = | 7.2 | 7.2 | -72 | 49 | PDSP KiDatabase | 287 | 0 | 0 | 1 | 4.7 | CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 | None | |||
2389 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
5073.0 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
96 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
CHEMBL85 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
DB00734 | 3331 | None | 72 | Human | Binding | pKi | = | 8.2 | 8.2 | -234 | 67 | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
135398745 | 2914 | None | 65 | Human | Binding | pKi | = | 8.2 | 8.2 | -26 | 65 | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
135398745.0 | 2914 | None | 65 | Human | Binding | pKi | = | 8.2 | 8.2 | -26 | 65 | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
47 | 2914 | None | 65 | Human | Binding | pKi | = | 8.2 | 8.2 | -26 | 65 | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
CHEMBL715 | 2914 | None | 65 | Human | Binding | pKi | = | 8.2 | 8.2 | -26 | 65 | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
DB00334 | 2914 | None | 65 | Human | Binding | pKi | = | 8.2 | 8.2 | -26 | 65 | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
1613 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
205 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
3964 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
3964.0 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
CHEMBL831 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
DB00408 | 2348 | None | 42 | Human | Binding | pKi | = | 8.2 | 8.2 | -5 | 44 | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
86 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | = | 8.1 | 8.1 | -54 | 85 | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
115237 | 55601 | None | 68 | Human | Binding | pKi | = | 8.1 | 8.1 | -11 | 54 | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
115237.0 | 55601 | None | 68 | Human | Binding | pKi | = | 8.1 | 8.1 | -11 | 54 | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
CHEMBL1621 | 55601 | None | 68 | Human | Binding | pKi | = | 8.1 | 8.1 | -11 | 54 | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
DB01267 | 55601 | None | 68 | Human | Binding | pKi | = | 8.1 | 8.1 | -11 | 54 | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
133538 | 3619 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -6 | 5 | PDSP KiDatabase | 317 | 1 | 2 | 3 | 3.7 | CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O | None | |||
8443 | 3619 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -6 | 5 | PDSP KiDatabase | 317 | 1 | 2 | 3 | 3.7 | CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O | None | |||
CHEMBL574558 | 3619 | 3H-SCH23390 | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -6 | 5 | PDSP KiDatabase | 317 | 1 | 2 | 3 | 3.7 | CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O | None | |||
37 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
460 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
54746 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
54746.0 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
CHEMBL1201087 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
DB00248 | 778 | None | 41 | Human | Binding | pKi | = | 8.1 | 8.1 | -5 | 17 | Drug Central | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | None | |||
228 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
33 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
6005 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
6005.0 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
CHEMBL53 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
DB00714 | 445 | None | 20 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 24 | Drug Central | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | None | |||
1212 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
204 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3372.0 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL726 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00623 | 1662 | None | 37 | Human | Binding | pKi | = | 8.1 | 8.1 | -28 | 65 | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
3389 | 220197 | None | 0 | Human | Binding | pKi | = | 8.1 | 8.1 | -1 | 26 | Drug Central | 549 | 12 | 0 | 6 | 6.8 | CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | None | |||
135398745 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
135398745.0 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
47 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
CHEMBL715 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
DB00334 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
1613 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
205 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
3964 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
3964.0 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
CHEMBL831 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
DB00408 | 2348 | 3H-SCH23390 | 42 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 44 | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
5281878 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
5281881 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
948 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
968 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL42055 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL54661 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00875 | 1660 | 3H-SCH23390 | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | PDSP KiDatabase | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
11976 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
667467 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
667467.0 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
CHEMBL908 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
DB01239 | 920 | None | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | Drug Central | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
5281878 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
5281881 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
948 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
968 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL42055 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
CHEMBL54661 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
DB00875 | 1660 | None | 22 | Human | Binding | pKi | = | 8.1 | 8.1 | -3 | 16 | Drug Central | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
1588 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
28864 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
28864.0 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
43 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL157138 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB00589 | 2325 | None | 21 | Human | Binding | pKi | = | 8.1 | 8.1 | -13 | 43 | Drug Central | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
1242 | 3613 | 3H-SCH23390 | 17 | Rat | Binding | pKi | = | 7.1 | 7.1 | -4 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
935 | 3613 | 3H-SCH23390 | 17 | Rat | Binding | pKi | = | 7.1 | 7.1 | -4 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
CHEMBL286080 | 3613 | 3H-SCH23390 | 17 | Rat | Binding | pKi | = | 7.1 | 7.1 | -4 | 17 | PDSP KiDatabase | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | None | |||
1153 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
12668023 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026874 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
30026875 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
3341.0 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
6603851 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
933 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
939 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
985 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1160786 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL1161520 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
CHEMBL588 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
DB00800 | 1628 | 3H-SCH23390 | 36 | Human | Binding | pKi | = | 6.1 | 6.1 | -22 | 10 | PDSP KiDatabase | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | None | |||
681 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
681.0 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
940 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
947 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
CHEMBL59 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
DB00988 | 1465 | None | 47 | Human | Binding | pKi | = | 8.1 | 8.1 | -67 | 38 | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
11976 | 920 | UNDEFINED | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
667467 | 920 | UNDEFINED | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
667467.0 | 920 | UNDEFINED | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
CHEMBL908 | 920 | UNDEFINED | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
DB01239 | 920 | UNDEFINED | 44 | Human | Binding | pKi | = | 8.1 | 8.1 | -8 | 23 | PDSP KiDatabase | 315 | 3 | 0 | 2 | 5.2 | CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl | None | |||
135398745 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
135398745.0 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
47 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
CHEMBL715 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
DB00334 | 2914 | 3H-SCH23390 | 65 | Human | Binding | pKi | = | 7.1 | 7.1 | -26 | 65 | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
None | 218719 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -2 | 4 | PDSP KiDatabase | 226 | 0 | 2 | 2 | 1.4 | C1CCC(=O)NCCCCCC(=O)NCC1 | None | |||
2105 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
47811 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
48 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
CHEMBL531 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
DB01186 | 3054 | 3H-SCH23390 | 28 | Human | Binding | pKi | = | 6.0 | 6.0 | -125 | 33 | PDSP KiDatabase | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | None | |||
None | 219619 | UNDEFINED | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -281 | 11 | PDSP KiDatabase | 116 | 4 | 0 | 2 | 1.4 | CCCCN(C)N=O | None | |||
None | 218720 | 3H-SCH23390 | 0 | Human | Binding | pKi | = | 6.0 | 6.0 | -1380 | 3 | PDSP KiDatabase | 315 | 6 | 1 | 3 | 4.3 | CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O | None | |||
681 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
681.0 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
940 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
947 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
CHEMBL59 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
DB00988 | 1465 | None | 47 | Human | Binding | pKi | = | 6.6 | 6.6 | -67 | 38 | Guide to Pharmacology | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 1826762 | |||
1242 | 3613 | None | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | Guide to Pharmacology | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 1826762 | |||
935 | 3613 | None | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | Guide to Pharmacology | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 1826762 | |||
CHEMBL286080 | 3613 | None | 17 | Human | Binding | pKi | = | 7 | 7.0 | -6 | 17 | Guide to Pharmacology | 255 | 1 | 3 | 3 | 2.4 | Oc1cc2CCNCC(c2cc1O)c1ccccc1 | 1826762 | |||
107930 | 1529 | None | 25 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 1826762 | |||
107930.0 | 1529 | None | 25 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 1826762 | |||
3304 | 1529 | None | 25 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 1826762 | |||
CHEMBL298406 | 1529 | None | 25 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 1826762 | |||
DB12273 | 1529 | None | 25 | Human | Binding | pKi | = | 8.3 | 8.3 | -1 | 6 | Guide to Pharmacology | 313 | 0 | 1 | 2 | 4.0 | CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O | 1826762 | |||
5018 | 3549 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 1826762 | |||
943 | 3549 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 1826762 | |||
946 | 3549 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 1826762 | |||
CHEMBL13668 | 3549 | None | 8 | Human | Binding | pKi | = | 8.5 | 8.5 | -2 | 9 | Guide to Pharmacology | 287 | 1 | 1 | 2 | 3.7 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O | 1826762 | |||
1243 | 3618 | None | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | Guide to Pharmacology | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 1826762 | |||
944 | 3618 | None | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | Guide to Pharmacology | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 1826762 | |||
CHEMBL324017 | 3618 | None | 30 | Human | Binding | pKi | = | 9.4 | 9.4 | -2 | 15 | Guide to Pharmacology | 331 | 1 | 1 | 2 | 3.8 | CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O | 1826762 | |||
11954224 | 218443 | None | 0 | Human | Binding | pKi | None | 8.2 | 8.2 | -478 | 59 | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
3251 | 218443 | None | 0 | Human | Binding | pKi | None | 8.2 | 8.2 | -478 | 59 | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
3251.0 | 218443 | None | 0 | Human | Binding | pKi | None | 8.2 | 8.2 | -478 | 59 | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
CHEMBL1982133 | 218443 | None | 0 | Human | Binding | pKi | None | 8.2 | 8.2 | -478 | 59 | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
DB00696 | 218443 | None | 0 | Human | Binding | pKi | None | 8.2 | 8.2 | -478 | 59 | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
2601 | 3780 | None | 25 | Human | Binding | pKi | None | 8.1 | 8.1 | -15 | 21 | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
443951 | 3780 | None | 25 | Human | Binding | pKi | None | 8.1 | 8.1 | -15 | 21 | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
56 | 3780 | None | 25 | Human | Binding | pKi | None | 8.1 | 8.1 | -15 | 21 | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
CHEMBL73151 | 3780 | None | 25 | Human | Binding | pKi | None | 8.1 | 8.1 | -15 | 21 | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
DB13399 | 3780 | None | 25 | Human | Binding | pKi | None | 8.1 | 8.1 | -15 | 21 | Drug Central | 340 | 3 | 2 | 2 | 2.9 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
3036780 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
3036780.0 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
46780481 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
9903970 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
9903970.0 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL3187365 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL3544974 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
CHEMBL504548 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
DB06216 | 107587 | None | 16 | Human | Binding | pKi | None | 8.1 | 8.1 | -77 | 53 | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
484 | 2858 | None | 34 | Human | Binding | pKi | None | 4.9 | 4.9 | -112 | 35 | Guide to Pharmacology | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | 1826762 | |||
951 | 2858 | None | 34 | Human | Binding | pKi | None | 4.9 | 4.9 | -112 | 35 | Guide to Pharmacology | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | 1826762 | |||
CHEMBL432 | 2858 | None | 34 | Human | Binding | pKi | None | 4.9 | 4.9 | -112 | 35 | Guide to Pharmacology | 169 | 2 | 4 | 4 | 0.1 | NCC(c1ccc(c(c1)O)O)O | 1826762 | |||
2470 | 3653 | None | 40 | Human | Binding | pKi | None | 5.3 | 5.3 | -14791 | 59 | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1826762 | |||
3300 | 3653 | None | 40 | Human | Binding | pKi | None | 5.3 | 5.3 | -14791 | 59 | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1826762 | |||
5265 | 3653 | None | 40 | Human | Binding | pKi | None | 5.3 | 5.3 | -14791 | 59 | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1826762 | |||
99 | 3653 | None | 40 | Human | Binding | pKi | None | 5.3 | 5.3 | -14791 | 59 | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1826762 | |||
CHEMBL267930 | 3653 | None | 40 | Human | Binding | pKi | None | 5.3 | 5.3 | -14791 | 59 | Guide to Pharmacology | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 1826762 | |||
5 | 139 | None | 45 | Human | Binding | pKi | None | 5.5 | 5.5 | -7244 | 54 | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1826762 | |||
5202 | 139 | None | 45 | Human | Binding | pKi | None | 5.5 | 5.5 | -7244 | 54 | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1826762 | |||
CHEMBL39 | 139 | None | 45 | Human | Binding | pKi | None | 5.5 | 5.5 | -7244 | 54 | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1826762 | |||
DB08839 | 139 | None | 45 | Human | Binding | pKi | None | 5.5 | 5.5 | -7244 | 54 | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1826762 | |||
1524 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
197 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
3822 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
3822.0 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
88 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
CHEMBL51 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
DB12465 | 2181 | None | 61 | Human | Binding | pKi | None | 5.6 | 5.6 | -234 | 51 | Guide to Pharmacology | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | 1826762 | |||
100 | 3805 | None | 44 | Human | Binding | pKi | None | 5.6 | 5.6 | -85 | 55 | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 1826762 | |||
2637 | 3805 | None | 44 | Human | Binding | pKi | None | 5.6 | 5.6 | -85 | 55 | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 1826762 | |||
5452 | 3805 | None | 44 | Human | Binding | pKi | None | 5.6 | 5.6 | -85 | 55 | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 1826762 | |||
CHEMBL479 | 3805 | None | 44 | Human | Binding | pKi | None | 5.6 | 5.6 | -85 | 55 | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 1826762 | |||
DB00679 | 3805 | None | 44 | Human | Binding | pKi | None | 5.6 | 5.6 | -85 | 55 | Guide to Pharmacology | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | 1826762 | |||
30137 | 2877 | None | 0 | Human | Binding | pKi | None | 5.9 | 5.9 | -3019 | 10 | Guide to Pharmacology | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
8594 | 2877 | None | 0 | Human | Binding | pKi | None | 5.9 | 5.9 | -3019 | 10 | Guide to Pharmacology | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
934 | 2877 | None | 0 | Human | Binding | pKi | None | 5.9 | 5.9 | -3019 | 10 | Guide to Pharmacology | 295 | 2 | 2 | 3 | 3.6 | CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
3153 | 297 | None | 18 | Human | Binding | pKi | None | 6 | 6.0 | -588 | 7 | Guide to Pharmacology | 179 | 0 | 3 | 3 | 0.9 | NC1CCc2c(C1)cc(c(c2)O)O | 1826762 | |||
932 | 297 | None | 18 | Human | Binding | pKi | None | 6 | 6.0 | -588 | 7 | Guide to Pharmacology | 179 | 0 | 3 | 3 | 0.9 | NC1CCc2c(C1)cc(c(c2)O)O | 1826762 | |||
CHEMBL26736 | 297 | None | 18 | Human | Binding | pKi | None | 6 | 6.0 | -588 | 7 | Guide to Pharmacology | 179 | 0 | 3 | 3 | 0.9 | NC1CCc2c(C1)cc(c(c2)O)O | 1826762 | |||
2407 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
59227 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
59227.0 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
941 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
CHEMBL1303 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
DB05271 | 3372 | None | 50 | Human | Binding | pKi | None | 6 | 6.0 | -83 | 7 | Guide to Pharmacology | 315 | 6 | 1 | 3 | 4.3 | CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1 | 1826762 | |||
1153 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
12668023 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
30026874 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
30026875 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
3341 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
3341.0 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
6603851 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
933 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
939 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
985 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL1160786 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL1161520 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL588 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
DB00800 | 1628 | None | 36 | Human | Binding | pKi | None | 6.1 | 6.1 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
31101 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
31101 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
31101.0 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
31101.0 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
35 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
35 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
403 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
403 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
CHEMBL493 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
CHEMBL493 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
DB01200 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 12388666 | |||
DB01200 | 729 | None | 28 | Human | Binding | pKi | None | 6.3 | 6.3 | -239 | 35 | Guide to Pharmacology | 653 | 5 | 3 | 6 | 3.2 | CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C | 1826762 | |||
1353 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
3559 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
3559.0 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
86 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
CHEMBL54 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
DB00502 | 1911 | None | 63 | Human | Binding | pKi | None | 6.3 | 6.3 | -54 | 85 | Guide to Pharmacology | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 1826762 | |||
937 | 3615 | None | 0 | Human | Binding | pKi | None | 6.3 | 6.3 | 1 | 2 | Guide to Pharmacology | None | None | None | None | 1826762 | |||||
135398737 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
135398737.0 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
38 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
722 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
CHEMBL42 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
DB00363 | 958 | None | 57 | Human | Binding | pKi | None | 6.6 | 6.6 | -89 | 91 | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 1826762 | |||
2105 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
2105 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 1826762 | |||
47811 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
47811 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 1826762 | |||
48 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
48 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 1826762 | |||
CHEMBL531 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
CHEMBL531 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 1826762 | |||
DB01186 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 12388666 | |||
DB01186 | 3054 | None | 28 | Human | Binding | pKi | None | 6.8 | 6.8 | -125 | 33 | Guide to Pharmacology | 314 | 4 | 1 | 2 | 4.3 | CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 | 1826762 | |||
161309 | 613 | None | 0 | Human | Binding | pKi | None | 6.9 | 6.9 | - | 1 | Guide to Pharmacology | 575 | 5 | 3 | 6 | 2.4 | CC[C@@H]([C@@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | 1826762 | |||
988 | 613 | None | 0 | Human | Binding | pKi | None | 6.9 | 6.9 | - | 1 | Guide to Pharmacology | 575 | 5 | 3 | 6 | 2.4 | CC[C@@H]([C@@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C | 1826762 | |||
2726 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
2726.0 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
621 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
83 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
CHEMBL71 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
DB00477 | 919 | None | 48 | Human | Binding | pKi | None | 6.9 | 6.9 | -47 | 72 | Guide to Pharmacology | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | 1826762 | |||
228 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
228 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
33 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
33 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
6005 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
6005 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
6005.0 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
6005.0 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
CHEMBL53 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
CHEMBL53 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
DB00714 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 12388666 | |||
DB00714 | 445 | None | 20 | Human | Binding | pKi | None | 7.1 | 7.1 | -3 | 24 | Guide to Pharmacology | 267 | 0 | 2 | 3 | 2.9 | CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O | 1826762 | |||
37459 | 746 | None | 9 | Human | Binding | pKi | None | 7.6 | 7.6 | -61 | 24 | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 1826762 | |||
62 | 746 | None | 9 | Human | Binding | pKi | None | 7.6 | 7.6 | -61 | 24 | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 1826762 | |||
CHEMBL8514 | 746 | None | 9 | Human | Binding | pKi | None | 7.6 | 7.6 | -61 | 24 | Guide to Pharmacology | 361 | 0 | 1 | 2 | 4.8 | O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C | 1826762 | |||
37 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
460 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
54746 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
54746.0 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
CHEMBL1201087 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
DB00248 | 778 | None | 41 | Human | Binding | pKi | None | 7.7 | 7.7 | -5 | 17 | Guide to Pharmacology | 451 | 8 | 2 | 4 | 3.2 | C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C | 12388666 | |||
1153 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
12668023 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
30026874 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
30026875 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
3341 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
3341.0 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
6603851 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
933 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
939 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
985 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL1160786 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL1161520 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
CHEMBL588 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
DB00800 | 1628 | None | 36 | Human | Binding | pKi | None | 7.8 | 7.8 | -22 | 10 | Guide to Pharmacology | 305 | 1 | 4 | 4 | 2.7 | Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O | 1826762 | |||
1212 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
204 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
3372 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
3372.0 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
CHEMBL726 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
DB00623 | 1662 | None | 37 | Human | Binding | pKi | None | 7.9 | 7.9 | -28 | 65 | Guide to Pharmacology | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
5281878 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
5281881 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
948 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
968 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
CHEMBL42055 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
CHEMBL54661 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
DB00875 | 1660 | None | 22 | Human | Binding | pKi | None | 8.1 | 8.1 | -3 | 16 | Guide to Pharmacology | 434 | 5 | 1 | 4 | 4.6 | OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F | 1826762 | |||
1588 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
28864 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
28864.0 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
43 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
CHEMBL157138 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 | |||
DB00589 | 2325 | None | 21 | Human | Binding | pKi | None | 8.5 | 8.5 | -13 | 43 | Guide to Pharmacology | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 12388666 |