Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
1218 3412 21 None 177 4 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
938 3412 21 None 177 4 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
CHEMBL353335 3412 21 None 177 4 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 289 1 3 3 3.0 Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1 10.1021/acsmedchemlett.9b00050
86764103 131675 4 None -2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 389 5 1 6 3.1 Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
CHEMBL3697578 131675 4 None -2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 389 5 1 6 3.1 Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
681 1376 59 None 1 11 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
940 1376 59 None 1 11 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
947 1376 59 None 1 11 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
CHEMBL59 1376 59 None 1 11 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
DB00988 1376 59 None 1 11 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/acsmedchemlett.9b00050
75202022 169994 1 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 363 3 1 6 3.3 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
CHEMBL4453318 169994 1 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at D5R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay
ChEMBL 363 3 1 6 3.3 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C 10.1021/acsmedchemlett.9b00050
11681599 74619 0 None - 0 Human 10.3 pKi = 10.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL203637 74619 0 None - 0 Human 10.3 pKi = 10.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
11623343 140065 1 None - 0 Human 9.3 pKi = 9.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL381936 140065 1 None - 0 Human 9.3 pKi = 9.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11493746 140544 0 None - 0 Human 8.9 pKi = 8.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 335 0 1 2 4.3 CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL383451 140544 0 None - 0 Human 8.9 pKi = 8.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 335 0 1 2 4.3 CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1 10.1021/jm051237e
11595240 139415 0 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
CHEMBL380464 139415 0 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
11558055 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL1204122 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL201170 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11558055 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL1204122 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL201170 72604 1 None - 0 Human 8.8 pKi = 8.8 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
11522339 74698 1 None - 0 Human 8.0 pKi = 8.0 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2c(O)cccc2CC1 10.1021/jm051237e
CHEMBL203689 74698 1 None - 0 Human 8.0 pKi = 8.0 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2c(O)cccc2CC1 10.1021/jm051237e
11500677 140071 1 None - 0 Human 6.0 pKi = 6.0 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL381946 140071 1 None - 0 Human 6.0 pKi = 6.0 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
11573806 74862 0 None - 0 Human 7.9 pKi = 7.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
CHEMBL204065 74862 0 None - 0 Human 7.9 pKi = 7.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
5249952 72860 6 None - 0 Human 7.0 pKi = 7.0 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.4 CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 10.1021/jm050846j
CHEMBL201584 72860 6 None - 0 Human 7.0 pKi = 7.0 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.4 CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1 10.1021/jm050846j
4350931 168498 33 None - 1 Human 7.9 pKi = 7.9 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL441618 168498 33 None - 1 Human 7.9 pKi = 7.9 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
4350931 168498 33 None - 1 Human 7.9 pKi = 7.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
CHEMBL441618 168498 33 None - 1 Human 7.9 pKi = 7.9 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm051237e
42626289 147300 0 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
CHEMBL393492 147300 0 None - 0 Human 6.9 pKi = 6.9 Functional
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 379 7 0 4 3.3 COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1 10.1016/j.bmc.2007.06.002
11566745 74142 0 None - 0 Human 8.6 pKi = 8.6 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL1202298 74142 0 None - 0 Human 8.6 pKi = 8.6 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL203029 74142 0 None - 0 Human 8.6 pKi = 8.6 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
16090814 80961 0 None - 0 Human 8.6 pKi = 8.6 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL216258 80961 0 None - 0 Human 8.6 pKi = 8.6 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
11716449 140436 0 None - 0 Human 7.7 pKi = 7.7 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
CHEMBL382850 140436 0 None - 0 Human 7.7 pKi = 7.7 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
5249956 72847 1 None - 0 Human 8.5 pKi = 8.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
CHEMBL201525 72847 1 None - 0 Human 8.5 pKi = 8.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
11573628 74147 0 None - 0 Human 8.5 pKi = 8.5 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
CHEMBL203047 74147 0 None - 0 Human 8.5 pKi = 8.5 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1 10.1021/jm051237e
11637457 72539 1 None - 0 Human 7.5 pKi = 7.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
CHEMBL201093 72539 1 None - 0 Human 7.5 pKi = 7.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1021/jm050846j
9992499 72838 0 None - 0 Human 6.5 pKi = 6.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
CHEMBL201483 72838 0 None - 0 Human 6.5 pKi = 6.5 Functional
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay
ChEMBL 254 0 0 2 2.6 CN1CCc2ccccc2Cc2ccn(C)c2CC1 10.1021/jm050846j
11716438 140105 1 None - 0 Human 7.4 pKi = 7.4 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
CHEMBL382010 140105 1 None - 0 Human 7.4 pKi = 7.4 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2cc(O)ccc2CC1 10.1021/jm051237e
44436300 148057 0 None - 0 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL394110 148057 0 None - 0 Human 6.4 pKi = 6.4 Functional
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium responseAntagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
11558247 74867 0 None - 0 Human 7.4 pKi = 7.4 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
CHEMBL204098 74867 0 None - 0 Human 7.4 pKi = 7.4 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
75201901 165621 11 None - 4 Human 8.3 pKi = 8.3 Functional
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.8b01622
CHEMBL4277264 165621 11 None - 4 Human 8.3 pKi = 8.3 Functional
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 356 3 0 6 4.9 Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 10.1021/acs.jmedchem.8b01622
11536995 138782 1 None - 0 Human 7.3 pKi = 7.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1cccc2c1Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL379662 138782 1 None - 0 Human 7.3 pKi = 7.3 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1cccc2c1Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
11718008 74737 0 None - 0 Human 7.2 pKi = 7.2 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 349 1 0 2 4.6 COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
CHEMBL203734 74737 0 None - 0 Human 7.2 pKi = 7.2 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 349 1 0 2 4.6 COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2 10.1021/jm051237e
44408818 139393 1 None - 0 Human 8.1 pKi = 8.1 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm051237e
CHEMBL380330 139393 1 None - 0 Human 8.1 pKi = 8.1 Functional
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay
ChEMBL 281 1 0 2 3.3 COc1ccc2c(c1)CCN(C)CCc1ccccc1C2 10.1021/jm051237e
16090821 81213 0 None - 0 Human 7.1 pKi = 7.1 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
CHEMBL216439 81213 0 None - 0 Human 7.1 pKi = 7.1 Functional
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay
ChEMBL 304 0 1 1 4.2 CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1 10.1021/jm060213k
122324 199 13 None -128 4 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870
6077 199 13 None -128 4 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870
CHEMBL86931 199 13 None -128 4 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 271 2 3 4 2.4 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1 16318870




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
85090335 180276 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 359 3 0 5 3.4 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2020.127696
CHEMBL4760355 180276 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 359 3 0 5 3.4 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2020.127696
85090318 178607 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 413 3 0 5 4.7 Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4740497 178607 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 413 3 0 5 4.7 Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090319 179772 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 401 3 0 6 3.9 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4754602 179772 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 401 3 0 6 3.9 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090328 180197 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.2 Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4759339 180197 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.2 Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090333 180463 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 2 0 5 4.6 Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4762375 180463 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 2 0 5 4.6 Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090332 179881 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 435 3 0 6 4.6 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4755709 179881 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 435 3 0 6 4.6 COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
2030130 20611 13 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.3 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL1311333 20611 13 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 385 2 0 5 4.3 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
85090338 179923 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 389 4 0 6 3.4 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4756163 179923 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 389 4 0 6 3.4 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090324 179854 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4755481 179854 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090325 178911 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4744261 178911 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 405 2 0 5 4.5 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090321 181976 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 373 3 0 5 3.7 Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4790909 181976 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 373 3 0 5 3.7 Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090329 181845 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4789255 181845 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
85090334 179787 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 3 0 5 4.4 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4754761 179787 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 399 3 0 5 4.4 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
85090323 181083 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4779641 181083 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2020.127696
85090326 181936 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 423 4 0 6 4.1 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4790277 181936 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 423 4 0 6 4.1 COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090331 180614 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 449 3 0 6 4.9 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4764398 180614 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 449 3 0 6 4.9 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090322 178621 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 415 3 0 6 4.3 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
CHEMBL4740678 178621 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 415 3 0 6 4.3 COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 10.1016/j.bmcl.2020.127696
85090339 181468 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 10.1016/j.bmcl.2020.127696
CHEMBL4784143 181468 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 393 3 0 5 4.1 CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1 10.1016/j.bmcl.2020.127696
85090320 181726 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4787728 181726 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
4901726 179961 9 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4756486 179961 9 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 419 2 0 5 4.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
76284418 181481 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 371 2 0 5 3.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4784295 181481 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 371 2 0 5 3.9 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
136326241 178590 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 295 1 1 4 2.4 Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4740312 178590 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 295 1 1 4 2.4 Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21 10.1016/j.bmcl.2020.127696
85090330 180235 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 463 4 0 6 5.0 COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
CHEMBL4759814 180235 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 463 4 0 6 5.0 COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl 10.1016/j.bmcl.2020.127696
85090337 182444 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4796761 182444 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 433 3 0 5 5.0 Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21 10.1016/j.bmcl.2020.127696
76284419 182411 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 343 2 0 5 3.1 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 10.1016/j.bmcl.2020.127696
CHEMBL4796389 182411 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
ChEMBL 343 2 0 5 3.1 Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21 10.1016/j.bmcl.2020.127696
3036864 198330 12 None -3 26 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL1256645 198330 12 None -3 26 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL1814790 198330 12 None -3 26 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
CHEMBL62 198330 12 None -3 26 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmc.2013.03.016
3036864 198330 12 None -3 26 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1256645 198330 12 None -3 26 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1814790 198330 12 None -3 26 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL62 198330 12 None -3 26 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
5018 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
943 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
946 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
CHEMBL13668 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting method
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.11.014
5018 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
943 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
946 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
CHEMBL13668 3349 9 None -2 9 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cells
ChEMBL 287 1 1 2 3.7 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O 10.1016/j.bmc.2016.03.006
3036864 198330 12 None -3 26 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1256645 198330 12 None -3 26 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1814790 198330 12 None -3 26 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL62 198330 12 None -3 26 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
10907460 9573 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9573 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
11071079 109890 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL325516 109890 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
11730467 10763 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL117537 10763 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
11113605 10245 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
CHEMBL116735 10245 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm010878g
10918307 9728 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 514 5 1 7 2.6 CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O 10.1021/jm010878g
CHEMBL114825 9728 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 514 5 1 7 2.6 CNC(=O)CN1CN(c2ccccc2)C2(CCN(C(=O)OCc3cc4c(cc3Cl)OCO4)CC2)C1=O 10.1021/jm010878g
11059058 9834 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 9834 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
11005810 10205 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL116463 10205 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10885636 110314 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL326263 110314 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human dopamine receptor D5Inhibition of human dopamine receptor D5
ChEMBL 503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
11681599 74619 0 None 12 6 Human 10.2 pKi = 10.2 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
CHEMBL203637 74619 0 None 12 6 Human 10.2 pKi = 10.2 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 10.1021/jm051237e
3036864 198330 12 None -3 26 Human 9.8 pKi = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1256645 198330 12 None -3 26 Human 9.8 pKi = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL1814790 198330 12 None -3 26 Human 9.8 pKi = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
CHEMBL62 198330 12 None -3 26 Human 9.8 pKi = 9.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand displacement assayBinding affinity to human dopamine D5 receptor by radioligand displacement assay
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.ejmech.2013.01.044
16665071 92758 0 None 7 4 Human 9.6 pKi = 9.6 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 334 1 0 3 3.8 COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 10.1016/j.bmcl.2006.11.093
CHEMBL245764 92758 0 None 7 4 Human 9.6 pKi = 9.6 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 334 1 0 3 3.8 COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 10.1016/j.bmcl.2006.11.093
3036864 198330 12 None -3 26 Human 9.5 pKi = 9.5 Binding
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL1256645 198330 12 None -3 26 Human 9.5 pKi = 9.5 Binding
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL1814790 198330 12 None -3 26 Human 9.5 pKi = 9.5 Binding
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
CHEMBL62 198330 12 None -3 26 Human 9.5 pKi = 9.5 Binding
Antagonist activity at dopamine D5 receptor (unknown origin)Antagonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2020.127305
44439943 92723 0 None 1 4 Human 9.4 pKi = 9.4 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL245570 92723 0 None 1 4 Human 9.4 pKi = 9.4 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 306 0 2 2 3.5 CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 10.1016/j.bmcl.2006.11.093
3036864 198330 12 None -3 26 Human 9.3 pKi = 9.3 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1256645 198330 12 None -3 26 Human 9.3 pKi = 9.3 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL1814790 198330 12 None -3 26 Human 9.3 pKi = 9.3 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
CHEMBL62 198330 12 None -3 26 Human 9.3 pKi = 9.3 Binding
Displacement of radiolabeled SCH-23390 from human dopamine D5 receptorDisplacement of radiolabeled SCH-23390 from human dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1021/jm8007618
6852376 90954 8 None 3 5 Human 9.3 pKi = 9.3 Binding
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL1467585 90954 8 None 3 5 Human 9.3 pKi = 9.3 Binding
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL24077 90954 8 None 3 5 Human 9.3 pKi = 9.3 Binding
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL503958 90954 8 None 3 5 Human 9.3 pKi = 9.3 Binding
Agonist activity at dopamine D5 receptor (unknown origin)Agonist activity at dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2020.127305
11778580 65597 1 None 5 5 Human 9.2 pKi = 9.2 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 283 0 1 3 2.9 CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm049720x
CHEMBL184050 65597 1 None 5 5 Human 9.2 pKi = 9.2 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 283 0 1 3 2.9 CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm049720x
16090814 80961 0 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
CHEMBL216258 80961 0 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells
ChEMBL 304 0 1 1 4.2 CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm060213k
11595240 139415 0 None -3 4 Human 9.0 pKi = 9.0 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
CHEMBL380464 139415 0 None -3 4 Human 9.0 pKi = 9.0 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 301 0 1 2 3.7 CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 10.1021/jm051237e
11488247 196218 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 470 5 1 4 4.5 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL599487 196218 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 470 5 1 4 4.5 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 10.1016/j.bmcl.2009.12.100
46231784 196916 0 None -2 4 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 329 0 2 3 3.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL604314 196916 0 None -2 4 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 329 0 2 3 3.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1039/C5MD00258C
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmcl.2006.11.093
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm070388+
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1016/j.bmc.2009.08.028
11558055 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL1204122 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
CHEMBL201170 72604 1 None -2 6 Human 8.8 pKi = 8.8 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 267 0 1 2 3.0 CN1CCc2ccccc2Cc2ccc(O)cc2CC1 10.1021/jm050846j
11623343 140065 1 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
CHEMBL381936 140065 1 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 10.1021/jm051237e
1243 3414 23 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
944 3414 23 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
CHEMBL324017 3414 23 None -3 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2021.128047
10402378 65595 0 None 19 5 Human 8.7 pKi = 8.7 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 1 0 3 3.2 COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 10.1021/jm049720x
CHEMBL184049 65595 0 None 19 5 Human 8.7 pKi = 8.7 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 297 1 0 3 3.2 COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 10.1021/jm049720x
122205438 136633 0 None -1 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 307 0 0 2 4.5 CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 10.1039/C5MD00258C
CHEMBL3753266 136633 0 None -1 5 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 307 0 0 2 4.5 CN1CCc2ccccc2Cc2sc3ccccc3c2CC1 10.1039/C5MD00258C
46216855 195957 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 395 1 1 3 5.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL597900 195957 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 395 1 1 3 5.7 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
46231925 196956 0 None -5 4 Human 8.0 pKi = 8 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 384 3 1 4 4.4 CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
CHEMBL604525 196956 0 None -5 4 Human 8.0 pKi = 8 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 384 3 1 4 4.4 CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
45379370 7280 0 None 2 5 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 10.1021/jm901291r
CHEMBL1087301 7280 0 None 2 5 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1 10.1021/jm901291r
11269330 197071 0 None -34 4 Human 8.0 pKi = 8.0 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 390 1 1 3 5.0 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL605127 197071 0 None -34 4 Human 8.0 pKi = 8.0 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 390 1 1 3 5.0 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
135398745 2752 104 None -28 71 Human 7.0 pKi = 7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
47 2752 104 None -28 71 Human 7.0 pKi = 7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
CHEMBL715 2752 104 None -28 71 Human 7.0 pKi = 7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
DB00334 2752 104 None -28 71 Human 7.0 pKi = 7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 10.1039/C2MD00311B
10947658 28323 0 None -912 16 Human 6.0 pKi = 6 Binding
Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
CHEMBL137781 28323 0 None -912 16 Human 6.0 pKi = 6 Binding
Binding affinity against Dopamine receptor D5Binding affinity against Dopamine receptor D5
ChEMBL 335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 10.1021/jm020153s
135398737 911 86 None -89 94 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
38 911 86 None -89 94 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
722 911 86 None -89 94 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
CHEMBL42 911 86 None -89 94 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
DB00363 911 86 None -89 94 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C2MD00311B
2389 3144 110 None -229 66 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
5073 3144 110 None -229 66 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
96 3144 110 None -229 66 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
CHEMBL85 3144 110 None -229 66 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
DB00734 3144 110 None -229 66 Human 6.0 pKi = 6 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 10.1039/C2MD00311B
155552185 173241 0 None -1819 16 Human 6.0 pKi = 6 Binding
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 491 10 2 5 4.3 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
CHEMBL4544086 173241 0 None -1819 16 Human 6.0 pKi = 6 Binding
Displacement of [3H] SCH23390 from D5 receptor (unknown origin)Displacement of [3H] SCH23390 from D5 receptor (unknown origin)
ChEMBL 491 10 2 5 4.3 COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1 10.1021/acs.jmedchem.9b01085
154724609 175775 1 None -11 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4514800 175775 1 None -11 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4597637 175775 1 None -11 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 440 10 0 6 4.8 COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
145969667 164162 0 None -41 6 Human 7.0 pKi = 7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225278 164162 0 None -41 6 Human 7.0 pKi = 7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
681 1376 59 None -67 37 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
940 1376 59 None -67 37 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
947 1376 59 None -67 37 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
CHEMBL59 1376 59 None -67 37 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
DB00988 1376 59 None -67 37 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
21527771 69612 0 None -40 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940404 69612 0 None -40 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 363 6 1 3 4.2 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
44415593 79629 0 None -104 6 Human 7.0 pKi = 7.0 Binding
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 495 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
CHEMBL213834 79629 0 None -104 6 Human 7.0 pKi = 7.0 Binding
Binding affinity at dopamine D5 receptorBinding affinity at dopamine D5 receptor
ChEMBL 495 2 1 5 5.6 CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1 10.1016/j.bmcl.2006.06.022
242 454 113 None -1071 53 Human 6.0 pKi = 6.0 Binding
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
34 454 113 None -1071 53 Human 6.0 pKi = 6.0 Binding
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
60795 454 113 None -1071 53 Human 6.0 pKi = 6.0 Binding
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
CHEMBL1112 454 113 None -1071 53 Human 6.0 pKi = 6.0 Binding
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
DB01238 454 113 None -1071 53 Human 6.0 pKi = 6.0 Binding
Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl nan
154704368 175647 1 None -229 6 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4569006 175647 1 None -229 6 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
CHEMBL4596571 175647 1 None -229 6 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 421 11 2 2 5.3 CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1 10.1021/acs.jmedchem.9b01835
126720252 163872 0 None -38 12 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
CHEMBL4216870 163872 0 None -38 12 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
11566745 74142 0 None 1 4 Human 6.0 pKi = 6.0 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL1202298 74142 0 None 1 4 Human 6.0 pKi = 6.0 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
CHEMBL203029 74142 0 None 1 4 Human 6.0 pKi = 6.0 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 283 0 2 3 2.7 CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1 10.1021/jm050846j
154704418 175763 1 None -2 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
CHEMBL4546749 175763 1 None -2 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
CHEMBL4597533 175763 1 None -2 5 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 458 12 1 6 4.8 Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1 10.1021/acs.jmedchem.9b01835
11408135 123431 0 None -245 3 Rat 5.0 pKi = 5.0 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
CHEMBL363406 123431 0 None -245 3 Rat 5.0 pKi = 5.0 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1ccc2c(c1)N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@H]1CC2 10.1021/jm049031l
5249956 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1039/C5MD00258C
CHEMBL201525 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1039/C5MD00258C
5249956 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1016/j.bmcl.2006.11.093
CHEMBL201525 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsBinding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1016/j.bmcl.2006.11.093
5249956 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
CHEMBL201525 72847 1 None -2 6 Human 8.0 pKi = 8.0 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 251 0 0 1 3.3 CN1CCc2ccccc2Cc2ccccc2CC1 10.1021/jm050846j
56594534 70056 0 None -1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO 10.1021/jm200676f
CHEMBL1949728 70056 0 None -1 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells
ChEMBL 320 1 2 2 3.2 CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO 10.1021/jm200676f
56597938 3714 0 None -1380 9 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
7651 3714 0 None -1380 9 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL2165126 3714 0 None -1380 9 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 461 7 1 4 5.2 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL4848838 183756 0 None 1 3 Human 6.0 pKi = 6.0 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 340 2 1 4 2.1 CC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
122181333 121125 0 None -7762 6 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 366 8 1 2 3.8 CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3590084 121125 0 None -7762 6 Human 5.0 pKi = 5.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 366 8 1 2 3.8 CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
154725276 175467 1 None -40 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4456964 175467 1 None -40 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595147 175467 1 None -40 6 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 478 12 1 3 6.5 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC 10.1021/acs.jmedchem.9b01835
11335419 66565 1 None -11 6 Human 7.0 pKi = 7.0 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 7 0 2 4.1 c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 10.1021/jm049720x
CHEMBL187367 66565 1 None -11 6 Human 7.0 pKi = 7.0 Binding
Binding affinity for human recombinant dopamine receptor D5Binding affinity for human recombinant dopamine receptor D5
ChEMBL 295 7 0 2 4.1 c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1 10.1021/jm049720x
21533446 69611 0 None -30 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
CHEMBL1940403 69611 0 None -30 10 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor by liquid scintillation counting
ChEMBL 379 6 1 3 4.9 OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.07.018
44436302 89991 0 None -23 4 Human 6.0 pKi = 6.0 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238917 89991 0 None -23 4 Human 6.0 pKi = 6.0 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmcl.2021.128028
44436302 89991 0 None -23 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238917 89991 0 None -23 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 429 7 0 6 2.4 COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/j.bmc.2007.06.002
681 1376 59 None -67 37 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
940 1376 59 None -67 37 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
947 1376 59 None -67 37 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
CHEMBL59 1376 59 None -67 37 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
DB00988 1376 59 None -67 37 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm401384w
11573806 74862 0 None -6 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
CHEMBL204065 74862 0 None -6 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2 10.1021/jm051237e
11151831 12845 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1190453 12845 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL540868 12845 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(O)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
154706513 175762 1 None -18 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
CHEMBL4440698 175762 1 None -18 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
CHEMBL4597532 175762 1 None -18 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 480 12 0 6 5.6 COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1 10.1021/acs.jmedchem.9b01835
53324045 56587 0 None -3 16 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 487 7 1 2 7.3 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL1644980 56587 0 None -3 16 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 487 7 1 2 7.3 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2018.10.036
3038495 675 25 None -831 19 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
7625 675 25 None -831 19 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
CHEMBL25236 675 25 None -831 19 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 417 8 1 4 4.2 COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2 10.1021/acs.jmedchem.9b01835
1242 3409 21 None -6 17 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
935 3409 21 None -6 17 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
CHEMBL286080 3409 21 None -6 17 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingDisplacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation counting
ChEMBL 255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1 10.1016/j.bmc.2011.08.033
33630 178121 89 None -5 27 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL47050 178121 89 None -5 27 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL4856060 184262 0 None -1 3 Human 5.9 pKi = 5.9 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 398 2 1 5 3.5 CC(C)(C)OC(=O)NCC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
11154178 195805 0 None -64 3 Human 7.9 pKi = 7.9 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 412 4 1 3 4.6 CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 10.1016/j.bmcl.2009.12.100
CHEMBL596824 195805 0 None -64 3 Human 7.9 pKi = 7.9 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 412 4 1 3 4.6 CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1 10.1016/j.bmcl.2009.12.100
122191607 122969 0 None -1778 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 468 9 1 3 5.0 CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 10.1021/acsmedchemlett.5b00131
CHEMBL3622099 122969 0 None -1778 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 468 9 1 3 5.0 CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1 10.1021/acsmedchemlett.5b00131
137654675 157832 0 None -3388 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 433 7 2 7 2.9 O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 10.1021/acs.jmedchem.7b00363
CHEMBL4092441 157832 0 None -3388 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 433 7 2 7 2.9 O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1 10.1021/acs.jmedchem.7b00363
11739113 12822 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1190331 12822 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL540613 12822 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 297 4 1 2 3.7 C=CCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
57391216 69624 0 None -66 8 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 332 6 0 5 2.9 Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940416 69624 0 None -66 8 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 332 6 0 5 2.9 Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
11716449 140436 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
CHEMBL382850 140436 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 304 1 1 1 4.2 CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 10.1021/jm050846j
CHEMBL4845850 183563 0 None -2 3 Human 5.9 pKi = 5.9 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 428 2 0 5 3.3 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
145988180 164428 0 None -12 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 303 10 1 2 5.3 CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4229178 164428 0 None -12 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 303 10 1 2 5.3 CCCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4848380 183725 0 None -2 5 Human 5.8 pKi = 5.8 Binding
Binding affinity to D5 receptor (unknown origin)Binding affinity to D5 receptor (unknown origin)
ChEMBL 503 5 1 2 7.2 O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 10.1021/acs.jmedchem.1c00164
44209480 69626 0 None -1318 11 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940418 69626 0 None -1318 11 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
11637457 72539 1 None -1 5 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1039/C5MD00258C
CHEMBL201093 72539 1 None -1 5 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2ccsc2CC1 10.1039/C5MD00258C
228 428 21 None -3 24 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
33 428 21 None -3 24 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
6005 428 21 None -3 24 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
CHEMBL53 428 21 None -3 24 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
DB00714 428 21 None -3 24 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D5 receptor expressed in CH4Cl cells incubated for 60 mins by radio ligand binding assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1016/j.bmcl.2020.127053
3246443 37282 2 None -2 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 325 1 1 5 2.8 COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
CHEMBL1457510 37282 2 None -2 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 325 1 1 5 2.8 COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4 10.1016/j.bmcl.2017.01.090
137636066 155446 0 None -9549 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 480 7 3 7 3.0 O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4064742 155446 0 None -9549 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 480 7 3 7 3.0 O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
11439436 12521 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188091 12521 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535151 12521 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
46227284 195296 0 None 1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.5 COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 10.1016/j.bmc.2009.08.028
CHEMBL593394 195296 0 None 1 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 281 1 0 2 3.5 COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2 10.1016/j.bmc.2009.08.028
90644071 111336 0 None -8 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 368 5 0 3 5.2 Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL3289655 111336 0 None -8 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 368 5 0 3 5.2 Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1 10.1016/j.bmc.2014.04.026
45379377 7214 0 None 1 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 274 0 1 1 3.7 c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 10.1021/jm901291r
CHEMBL1086790 7214 0 None 1 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 274 0 1 1 3.7 c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21 10.1021/jm901291r
44591134 175378 0 None -125 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL459373 175378 0 None -125 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 535 11 0 5 7.7 CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
72164182 91506 0 None -25 5 Human 5.8 pKi = 5.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl 10.1016/j.bmcl.2013.07.033
CHEMBL2420777 91506 0 None -25 5 Human 5.8 pKi = 5.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl 10.1016/j.bmcl.2013.07.033
154703647 175541 1 None -28 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4450429 175541 1 None -28 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
CHEMBL4595728 175541 1 None -28 5 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 468 12 0 6 5.6 CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C 10.1021/acs.jmedchem.9b01835
6603820 95119 11 None -1 15 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 10.1016/j.bmc.2009.08.028
CHEMBL25856 95119 11 None -1 15 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from rat dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 3 3 2.6 Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2 10.1016/j.bmc.2009.08.028
10200496 82970 0 None -30 5 Human 7.8 pKi = 7.8 Binding
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 391 6 1 3 3.6 O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1021/jm1013693
CHEMBL2204343 82970 0 None -30 5 Human 7.8 pKi = 7.8 Binding
Inhibition of human dopamine D5 receptorInhibition of human dopamine D5 receptor
ChEMBL 391 6 1 3 3.6 O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1021/jm1013693
242 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
34 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
60795 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
CHEMBL1112 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
DB01238 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1016/j.bmc.2017.08.037
242 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
34 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
60795 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL1112 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
DB01238 454 113 None -1071 53 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1021/acs.jmedchem.7b00363
CHEMBL4875858 185561 0 None 3 2 Human 5.8 pKi = 5.8 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 371 1 0 3 3.2 O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F 10.1016/j.bmcl.2021.128008
137655795 157781 0 None -6309 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 453 7 2 7 3.0 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4091933 157781 0 None -6309 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 453 7 2 7 3.0 O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1 10.1021/acs.jmedchem.7b00363
137660046 158540 0 None -22387 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 437 7 2 8 2.4 O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 10.1021/acs.jmedchem.7b00363
CHEMBL4100183 158540 0 None -22387 6 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 437 7 2 8 2.4 O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1 10.1021/acs.jmedchem.7b00363
11324023 12538 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188254 12538 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535823 12538 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 299 4 1 2 3.9 CCCN(C)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11416811 12552 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188384 12552 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL536271 12552 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(OC)c(F)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11438636 12844 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL1190452 12844 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL540867 12844 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 285 3 0 2 3.5 COc1cc2c(cc1F)C[C@@H](N(C)C)[C@@H]2c1ccccc1 10.1021/jm040889k
11818686 13620 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
CHEMBL1196231 13620 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
CHEMBL556194 13620 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)[C@@H](c1ccccc1)[C@H](N)C2 10.1021/jm040889k
85658088 164200 0 None -5 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 219 4 1 2 3.0 CCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225830 164200 0 None -5 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 219 4 1 2 3.0 CCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
44436300 148057 0 None -64 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL394110 148057 0 None -64 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2021.128028
44436300 148057 0 None -64 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL394110 148057 0 None -64 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 399 6 0 5 2.4 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccccc2)CC1 10.1016/j.bmc.2007.06.002
17755866 142104 1 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm070388+
CHEMBL389356 142104 1 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells
ChEMBL 281 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2CC1 10.1021/jm070388+
180 385 45 None -112 38 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
200 385 45 None -112 38 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
2160 385 45 None -112 38 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
CHEMBL629 385 45 None -112 38 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
DB00321 385 45 None -112 38 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1016/j.bmcl.2008.09.012
44436305 153624 0 None -23 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 430 6 0 5 4.0 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL398813 153624 0 None -23 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 430 6 0 5 4.0 O=c1c2ccccc2ncn1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
11464115 68093 0 None -89 3 Rat 5.8 pKi = 5.8 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
CHEMBL191815 68093 0 None -89 3 Rat 5.8 pKi = 5.8 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
2726 877 58 None -47 72 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
621 877 58 None -47 72 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
83 877 58 None -47 72 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
CHEMBL71 877 58 None -47 72 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
DB00477 877 58 None -47 72 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C 10.1016/j.bmcl.2008.09.012
154705520 175437 1 None -114 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4452683 175437 1 None -114 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4594959 175437 1 None -114 6 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 448 11 1 3 5.6 CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
76314268 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115577 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139633 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
72164180 91501 0 None -38 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl 10.1016/j.bmcl.2013.07.033
CHEMBL2420772 91501 0 None -38 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 326 3 0 3 4.4 Clc1cccc(N2CCN(Cc3cccs3)CC2)c1Cl 10.1016/j.bmcl.2013.07.033
11134444 89990 0 None -17 7 Human 5.8 pKi = 5.8 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238916 89990 0 None -17 7 Human 5.8 pKi = 5.8 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2021.128028
11134444 89990 0 None -17 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238916 89990 0 None -17 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 467 6 0 5 3.5 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
57401819 69616 0 None -229 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 346 6 0 2 4.6 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940408 69616 0 None -229 7 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 346 6 0 2 4.6 Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
76314268 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115577 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139633 105739 0 None -1230 4 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 450 3 1 4 3.5 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2 10.1021/jm401384w
46227325 195706 0 None 1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2C1 10.1016/j.bmc.2009.08.028
CHEMBL596179 195706 0 None 1 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 267 0 1 2 3.4 CN1CCCc2cc(O)ccc2Cc2ccccc2C1 10.1016/j.bmc.2009.08.028
11358377 197916 0 None 2 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 295 0 0 3 3.5 CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 10.1016/j.bmc.2009.08.028
CHEMBL610449 197916 0 None 2 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 295 0 0 3 3.5 CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3 10.1016/j.bmc.2009.08.028
154726793 175410 1 None -61 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4590966 175410 1 None -61 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4594692 175410 1 None -61 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 454 11 0 6 5.2 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
46227317 195742 0 None -1 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 265 1 0 2 3.4 COc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
CHEMBL596448 195742 0 None -1 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting
ChEMBL 265 1 0 2 3.4 COc1ccc2c(c1)CCN1Cc3ccccc3CC21 10.1016/j.bmc.2009.08.028
44436306 96541 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL268371 96541 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 417 6 0 3 4.2 O=C1Cc2ccccc2N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1016/j.bmc.2007.06.002
137645830 157056 0 None -478 6 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 424 7 1 8 2.8 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 10.1021/acs.jmedchem.7b00363
CHEMBL4083727 157056 0 None -478 6 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D5R expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 424 7 1 8 2.8 Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2 10.1021/acs.jmedchem.7b00363
11449266 13674 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL1196658 13674 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
CHEMBL557781 13674 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 257 2 1 2 2.9 COc1cc2c(cc1F)C[C@@H](N)[C@@H]2c1ccccc1 10.1021/jm040889k
11449669 13675 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1196659 13675 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL557782 13675 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 271 3 1 2 3.1 CN[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11210215 13726 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1197038 13726 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL559164 13726 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 311 5 0 2 4.0 C=CCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
76336022 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115581 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139316 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
11775107 165412 0 None -588 3 Rat 5.7 pKi = 5.7 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
CHEMBL426629 165412 0 None -588 3 Rat 5.7 pKi = 5.7 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1N1CCN(CCCCNC(=O)c3ccc4ccccc4c3)C[C@@H]1CC2 10.1021/jm049031l
76336022 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3115581 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
CHEMBL3139316 105684 0 None -512 3 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 386 6 1 5 3.3 Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(OCCF)cc3)CC1)CC2 10.1021/jm401384w
135398737 911 86 None -89 94 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
38 911 86 None -89 94 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
722 911 86 None -89 94 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
CHEMBL42 911 86 None -89 94 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
DB00363 911 86 None -89 94 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1016/j.bmcl.2008.09.012
75306277 108553 0 None -99 23 Human 6.7 pKi = 6.7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
CHEMBL3217984 108553 0 None -99 23 Human 6.7 pKi = 6.7 Binding
Binding affinity to dopamine D5 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D5 receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
90644062 111328 0 None -104 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289647 111328 0 None -104 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
154727843 175609 1 None -17 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4448853 175609 1 None -17 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4596221 175609 1 None -17 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 486 13 0 6 5.6 CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
107930 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
3304 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
CHEMBL298406 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
DB12273 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.100
107930 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
3304 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
CHEMBL298406 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
DB12273 1437 14 None -1 6 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 313 0 1 2 4.0 CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O 10.1016/j.bmcl.2009.12.094
46231927 197114 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 432 3 1 4 5.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL605354 197114 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 432 3 1 4 5.4 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
1243 3414 23 None -3 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
944 3414 23 None -3 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
CHEMBL324017 3414 23 None -3 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human D5 receptorBinding affinity to human D5 receptor
ChEMBL 331 1 1 2 3.8 CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O 10.1016/j.bmcl.2020.127053
45379369 7279 0 None 1 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 10.1021/jm901291r
CHEMBL1087300 7279 0 None 1 5 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting
ChEMBL 290 0 1 1 3.8 CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1 10.1021/jm901291r
46231926 196158 0 None -12 4 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 446 4 1 4 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL599135 196158 0 None -12 4 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 446 4 1 4 5.5 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
3036864 198330 12 None -3 26 Human 8.6 pKi = 8.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL1256645 198330 12 None -3 26 Human 8.6 pKi = 8.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL1814790 198330 12 None -3 26 Human 8.6 pKi = 8.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
CHEMBL62 198330 12 None -3 26 Human 8.6 pKi = 8.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 287 1 1 2 3.7 CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 10.1016/j.bmcl.2009.12.100
11416809 12531 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1188198 12531 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL535602 12531 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 313 5 0 2 4.2 CCCN(C)[C@@H]1Cc2cc(F)c(OC)cc2[C@H]1c1ccccc1 10.1021/jm040889k
23653176 90560 0 None 4 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.8 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL239917 90560 0 None 4 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 383 6 0 3 3.8 O=C1Cc2ccccc2N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
763625 91504 7 None -19 2 Human 5.7 pKi = 5.7 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 276 3 0 3 3.2 Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
CHEMBL2420775 91504 7 None -19 2 Human 5.7 pKi = 5.7 Binding
Binding affinity to human dopamine D5 receptor by radioligand binding assayBinding affinity to human dopamine D5 receptor by radioligand binding assay
ChEMBL 276 3 0 3 3.2 Fc1ccc(N2CCN(Cc3cccs3)CC2)cc1 10.1016/j.bmcl.2013.07.033
1212 1552 42 None -28 66 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
204 1552 42 None -28 66 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
3372 1552 42 None -28 66 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
CHEMBL726 1552 42 None -28 66 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
DB00623 1552 42 None -28 66 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1016/j.bmcl.2008.09.012
CHEMBL4857492 184352 0 None -2 6 Human 5.7 pKi = 5.7 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 389 2 1 4 3.7 O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1 10.1016/j.bmcl.2021.128008
CHEMBL4872572 185333 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of dopamine D5 receptor (unknown origin)Inhibition of dopamine D5 receptor (unknown origin)
ChEMBL 325 1 0 3 4.0 CC(C)(C)C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 10.1016/j.bmcl.2021.128008
122177644 120467 0 None -17378 6 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
CHEMBL3577345 120467 0 None -17378 6 Human 4.7 pKi = 4.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 591 18 2 8 5.6 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1 10.1021/jm501889t
154725234 175469 1 None -3 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4585289 175469 1 None -3 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
CHEMBL4595149 175469 1 None -3 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 472 12 0 6 5.2 CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF 10.1021/acs.jmedchem.9b01835
90644062 111328 0 None -104 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289647 111328 0 None -104 5 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 345 6 0 4 3.8 Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
46231924 196157 0 None -5 4 Human 7.7 pKi = 7.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 370 2 1 4 4.0 CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
CHEMBL599134 196157 0 None -5 4 Human 7.7 pKi = 7.7 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 370 2 1 4 4.0 CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.094
154705128 175468 1 None -151 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4454872 175468 1 None -151 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
CHEMBL4595148 175468 1 None -151 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method
ChEMBL 462 12 1 3 6.0 CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC 10.1021/acs.jmedchem.9b01835
156020558 177222 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 1 2 3 3.5 CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
CHEMBL4647167 177222 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 347 1 2 3 3.5 CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1 10.1016/j.bmcl.2020.127305
11558247 74867 0 None -6 3 Human 6.6 pKi = 6.6 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
CHEMBL204098 74867 0 None -6 3 Human 6.6 pKi = 6.6 Binding
Binding affinity to D5 dopamine receptor by radioligand binding assayBinding affinity to D5 dopamine receptor by radioligand binding assay
ChEMBL 282 0 2 3 2.6 CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1 10.1021/jm051237e
145969667 164162 0 None -41 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4225278 164162 0 None -41 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 289 9 1 2 4.9 CCCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
44436301 89989 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
CHEMBL238915 89989 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Binding affinity to human D5RBinding affinity to human D5R
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2021.128028
44436301 89989 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
CHEMBL238915 89989 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293
ChEMBL 433 6 0 5 3.1 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ccc(Cl)cc2)CC1 10.1016/j.bmc.2007.06.002
135398737 911 86 None -89 94 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
38 911 86 None -89 94 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
722 911 86 None -89 94 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
CHEMBL42 911 86 None -89 94 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
DB00363 911 86 None -89 94 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D5 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 10.1039/C5MD00258C
44209472 69628 2 None -1318 11 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940420 69628 2 None -1318 11 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2014.04.026
181743 177744 4 None -1202 22 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
CHEMBL467094 177744 4 None -1202 22 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH233930 from human dopamine D5 receptorDisplacement of [3H]SCH233930 from human dopamine D5 receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
122177641 120464 0 None -38018 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
CHEMBL3577342 120464 0 None -38018 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 551 18 1 8 4.6 C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1 10.1021/jm501889t
161665 171767 29 None -3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
CHEMBL448891 171767 29 None -3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr
ChEMBL 341 3 1 5 3.1 COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2 10.1016/j.bmcl.2017.01.090
681 1376 59 None -67 37 Human 5.6 pKi = 5.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
940 1376 59 None -67 37 Human 5.6 pKi = 5.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
947 1376 59 None -67 37 Human 5.6 pKi = 5.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
CHEMBL59 1376 59 None -67 37 Human 5.6 pKi = 5.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
DB00988 1376 59 None -67 37 Human 5.6 pKi = 5.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 153 2 3 3 0.6 NCCc1ccc(c(c1)O)O 10.1021/jm040889k
6852376 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL1467585 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL24077 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL503958 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
76325152 105676 0 None -251 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3115579 105676 0 None -251 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3139262 105676 0 None -251 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
6852376 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL1467585 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL24077 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
CHEMBL503958 90954 8 None 3 5 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 255 1 3 3 2.4 Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2 10.1016/j.bmcl.2013.12.024
156015018 176747 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 337 2 2 3 4.0 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
CHEMBL4640497 176747 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 337 2 2 3 4.0 COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2 10.1016/j.bmcl.2020.127305
122177643 120466 0 None -15848 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 632 20 3 9 5.1 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 10.1021/jm501889t
CHEMBL3577344 120466 0 None -15848 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis
ChEMBL 632 20 3 9 5.1 CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1 10.1021/jm501889t
90644061 111327 0 None -2344 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289646 111327 0 None -2344 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
90644061 111327 0 None -2344 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
CHEMBL3289646 111327 0 None -2344 5 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 329 6 0 4 3.1 Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1 10.1016/j.bmc.2014.04.026
11223708 165505 0 None -16 3 Rat 6.6 pKi = 6.6 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
CHEMBL427173 165505 0 None -16 3 Rat 6.6 pKi = 6.6 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 413 6 1 3 4.5 O=C(NCCCCN1CCN2c3ccccc3CC[C@H]2C1)c1ccc2ccccc2c1 10.1021/jm049031l
46231848 196117 0 None -8 4 Human 7.6 pKi = 7.6 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 396 1 1 3 4.1 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
CHEMBL598949 196117 0 None -8 4 Human 7.6 pKi = 7.6 Binding
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation countingDisplacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting
ChEMBL 396 1 1 3 4.1 CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21 10.1016/j.bmcl.2009.12.094
1353 1795 83 None -53 84 Human 6.6 pKi = 6.6 Binding
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
3559 1795 83 None -53 84 Human 6.6 pKi = 6.6 Binding
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
86 1795 83 None -53 84 Human 6.6 pKi = 6.6 Binding
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
CHEMBL54 1795 83 None -53 84 Human 6.6 pKi = 6.6 Binding
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
DB00502 1795 83 None -53 84 Human 6.6 pKi = 6.6 Binding
Compound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D5 by Radio ligand ([3H]SCH-23390) binding assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1021/jm9601720
11246806 12733 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL1189734 12733 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
CHEMBL539334 12733 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranesInhibitory constant for [3H]SCH-23390 binding to Dopamine receptor D1-like of porcine striatal membranes
ChEMBL 327 6 1 2 4.7 CCCN(CCC)[C@@H]1Cc2cc(F)c(O)cc2[C@H]1c1ccccc1 10.1021/jm040889k
11522476 73971 0 None -5 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 10.1021/jm050846j
CHEMBL202924 73971 0 None -5 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay
ChEMBL 311 2 0 3 3.3 COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2 10.1021/jm050846j
156017805 177002 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 343 4 1 3 4.2 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 10.1016/j.bmcl.2020.127305
CHEMBL4643886 177002 0 None -5 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)
ChEMBL 343 4 1 3 4.2 C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1 10.1016/j.bmcl.2020.127305
25212275 173602 0 None -6309 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL455288 173602 0 None -6309 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 682 13 0 8 7.4 O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
25212276 189052 0 None -741 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL517244 189052 0 None -741 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 508 11 0 3 7.4 CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
57391307 69619 0 None -389 7 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 348 6 0 3 4.1 Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940411 69619 0 None -389 7 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 348 6 0 3 4.1 Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
146025727 170870 0 None 4 27 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
CHEMBL4466483 170870 0 None 4 27 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method
ChEMBL 411 3 0 5 6.4 FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 10.1021/acs.jmedchem.9b00351
11316709 167556 0 None -323 3 Rat 5.6 pKi = 5.6 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
CHEMBL434532 167556 0 None -323 3 Rat 5.6 pKi = 5.6 Binding
Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brain
ChEMBL 443 7 1 4 4.5 COc1cccc2c1CC[C@@H]1CN(CCCCNC(=O)c3ccc4ccccc4c3)CCN21 10.1021/jm049031l
44591099 175368 0 None -1023 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL459350 175368 0 None -1023 6 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 494 10 0 3 7.0 CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
76325156 105695 1 None -12302 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3115585 105695 1 None -12302 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3139393 105695 1 None -12302 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
76325156 105695 1 None -12302 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3115585 105695 1 None -12302 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
CHEMBL3139393 105695 1 None -12302 6 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 263 7 2 3 3.3 CCCCCCNC[C@H]1CCc2ccc(O)cc2O1 10.1021/jm401384w
46869265 15916 0 None -13 7 Human 5.6 pKi = 5.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
CHEMBL1224527 15916 0 None -13 7 Human 5.6 pKi = 5.6 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21 10.1016/j.bmc.2010.07.052
CHEMBL3590077 121118 0 None -933 6 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 413 8 1 5 4.2 COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1 10.1016/j.bmc.2014.12.012
57401820 69617 0 None -323 7 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 364 6 0 3 4.8 Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
CHEMBL1940409 69617 0 None -323 7 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor by PDSP assay
ChEMBL 364 6 0 3 4.8 Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2014.04.026
145967572 164130 0 None -56 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 275 8 1 2 4.5 CCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
CHEMBL4224763 164130 0 None -56 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cell membranes by radioligand binding assay
ChEMBL 275 8 1 2 4.5 CCCCCCCCN1CCC(c2cccc(O)c2)C1 10.1016/j.bmcl.2018.03.084
76325152 105676 0 None -251 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3115579 105676 0 None -251 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
CHEMBL3139262 105676 0 None -251 5 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D5 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis
ChEMBL 359 9 2 4 4.0 Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2 10.1021/jm401384w
122181329 121121 0 None -9332 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 394 10 1 2 4.6 CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
CHEMBL3590080 121121 0 None -9332 6 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293 cell membranes
ChEMBL 394 10 1 2 4.6 CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1 10.1016/j.bmc.2014.12.012
44591135 189074 0 None -190 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 532 10 0 4 8.0 CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
CHEMBL517407 189074 0 None -190 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells
ChEMBL 532 10 0 4 8.0 CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1 10.1016/j.bmcl.2008.09.012
122205437 136545 0 None 7 5 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2sccc2CC1 10.1039/C5MD00258C
CHEMBL3752512 136545 0 None 7 5 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assayBinding affinity to human cloned D5 dopamine receptor incubated for 90 mins by radioligand binding assay
ChEMBL 257 0 0 2 3.4 CN1CCc2ccccc2Cc2sccc2CC1 10.1039/C5MD00258C
11486421 196772 0 None -2 3 Human 8.5 pKi = 8.5 Binding
Binding affinity to dopamine D5 receptorBinding affinity to dopamine D5 receptor
ChEMBL 400 2 2 4 4.5 CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C 10.1016/j.bmcl.2009.12.100
CHEMBL603485 196772 0