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Ligand source activities (1 row/activity)

Ligand Receptor Assay information Chemical information
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172198 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 400 40 AGTR1 AT1 receptor Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
127030943 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127030943 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 138400 0 AGTR1 AT1 receptor Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
172198 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 400 40 AGTRA AT1 receptor Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
127029976 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029976 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 138422 0 AGTR1 AT1 receptor Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
155540547 171679 0 AGTR1 AT1 receptor Human 8.0 pEC50 = 8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 171679 0 AGTR1 AT1 receptor Human 8.0 pEC50 = 8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155539027 171980 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 171980 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155541295 172167 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 172167 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155547844 172853 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 172853 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155564502 174414 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 174414 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155565112 174652 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 174652 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 172706 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 172706 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568289 175279 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 175279 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155557139 173699 0 AGTR1 AT1 receptor Human 5.0 pEC50 = 5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 173699 0 AGTR1 AT1 receptor Human 5.0 pEC50 = 5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520024 172401 0 AGTRA AT1 receptor Rat 5.0 pEC50 = 5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 172401 0 AGTRA AT1 receptor Rat 5.0 pEC50 = 5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155557139 173699 0 AGTRA AT1 receptor Rat 5.0 pEC50 = 5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 173699 0 AGTRA AT1 receptor Rat 5.0 pEC50 = 5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL938 207999 18 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
11943 3635 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
145925549 3635 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4438122 3635 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155558059 173838 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 173838 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155544988 172597 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 172597 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155541440 172176 0 AGTR1 AT1 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 172176 0 AGTR1 AT1 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155541440 172176 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 172176 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155540033 172046 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172046 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155541125 172121 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172121 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155540470 171634 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 171634 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559120 173941 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 173941 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155564502 174414 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 174414 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54696627 97653 0 AGTR1 AT1 receptor Bovine 5.9 pEC50 = 5.9 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
CHEMBL27511 97653 0 AGTR1 AT1 receptor Bovine 5.9 pEC50 = 5.9 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
54726669 98570 0 AGTR1 AT1 receptor Bovine 5.9 pEC50 = 5.9 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
CHEMBL281887 98570 0 AGTR1 AT1 receptor Bovine 5.9 pEC50 = 5.9 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
155539027 171980 0 AGTR1 AT1 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 171980 0 AGTR1 AT1 receptor Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155541295 172167 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 172167 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155547428 172770 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 172770 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 173428 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 173428 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543091 172335 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 172335 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520014 172391 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 172391 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2028943 202659 0 AGTRA AT1 receptor Rat 7.9 pEC50 = 7.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
CHEMBL2370909 203471 0 AGTRA AT1 receptor Rat 6.9 pEC50 = 6.9 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155542907 172332 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 172332 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155563676 174498 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 174498 0 AGTR1 AT1 receptor Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155540639 172089 0 AGTRA AT1 receptor Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172089 0 AGTRA AT1 receptor Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2392353 203929 4 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
3082475 3637 6 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3637 6 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3637 6 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3637 6 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155568804 175272 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 175272 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL2028943 202659 0 AGTR1 AT1 receptor Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155541240 172172 0 AGTR1 AT1 receptor Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 172172 0 AGTR1 AT1 receptor Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 174454 0 AGTR1 AT1 receptor Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 174454 0 AGTR1 AT1 receptor Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155554529 173788 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 173788 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
10533900 175122 2 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175122 2 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155544246 172521 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 172521 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553003 173230 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 173230 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155561477 174346 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 174346 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 174375 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 174375 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155553930 174594 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 174594 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553930 174594 0 AGTRA AT1 receptor Rat 4.8 pEC50 = 4.8 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 174594 0 AGTRA AT1 receptor Rat 4.8 pEC50 = 4.8 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155551279 173141 0 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
CHEMBL4542269 173141 0 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
3082475 3637 6 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3637 6 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3637 6 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3637 6 AGTR1 AT1 receptor Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
70538373 174651 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 174651 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
155554865 173509 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 173509 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54726671 93946 0 AGTR1 AT1 receptor Bovine 5.8 pEC50 = 5.8 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL25226 93946 0 AGTR1 AT1 receptor Bovine 5.8 pEC50 = 5.8 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155560095 174077 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 174077 0 AGTRA AT1 receptor Rat 7.8 pEC50 = 7.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155563538 174454 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 174454 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155565687 174736 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 174736 0 AGTRA AT1 receptor Rat 6.8 pEC50 = 6.8 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556507 173641 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 173641 0 AGTR1 AT1 receptor Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726670 93291 0 AGTR1 AT1 receptor Bovine 5.8 pEC50 = 5.8 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL24842 93291 0 AGTR1 AT1 receptor Bovine 5.8 pEC50 = 5.8 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155560463 174195 0 AGTRA AT1 receptor Rat 7.7 pEC50 = 7.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 174195 0 AGTRA AT1 receptor Rat 7.7 pEC50 = 7.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155540033 172046 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172046 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155553003 173230 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 173230 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155554865 173509 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 173509 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155564502 174414 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 174414 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
127029977 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029977 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 138423 0 AGTR1 AT1 receptor Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127031545 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127031545 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 138401 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
172198 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 400 40 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155541440 172176 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 172176 0 AGTR1 AT1 receptor Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155560463 174195 0 AGTR1 AT1 receptor Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 174195 0 AGTR1 AT1 receptor Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
10533900 175122 2 AGTRA AT1 receptor Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175122 2 AGTRA AT1 receptor Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155551762 173164 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 173164 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155556507 173641 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 173641 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155552995 173266 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 173266 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155556530 173666 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 173666 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155568109 175191 0 AGTR1 AT1 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 175191 0 AGTR1 AT1 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2392353 203929 4 AGTR1 AT1 receptor Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155556530 173666 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 173666 0 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
11944 3636 0 AGTR1 AT1 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3636 0 AGTR1 AT1 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3636 0 AGTR1 AT1 receptor Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540470 171634 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 171634 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553311 173287 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 173287 0 AGTRA AT1 receptor Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 175142 4 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175142 4 AGTR1 AT1 receptor Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155563538 174454 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 174454 0 AGTRA AT1 receptor Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
54726676 98527 0 AGTR1 AT1 receptor Bovine 5.7 pEC50 = 5.7 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28162 98527 0 AGTR1 AT1 receptor Bovine 5.7 pEC50 = 5.7 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155540328 172057 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172057 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155559104 173961 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 173961 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155554865 173509 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 173509 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155547428 172770 0 AGTR1 AT1 receptor Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 172770 0 AGTR1 AT1 receptor Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568318 175254 0 AGTR1 AT1 receptor Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 175254 0 AGTR1 AT1 receptor Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155559827 174070 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 174070 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155540328 172057 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172057 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155565112 174652 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 174652 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553479 173332 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 173332 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558003 173848 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 173848 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558784 173931 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 173931 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155547428 172770 0 AGTRA AT1 receptor Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 172770 0 AGTRA AT1 receptor Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 174899 0 AGTRA AT1 receptor Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 174899 0 AGTRA AT1 receptor Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558428 173884 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 173884 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
11944 3636 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155552190 3636 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4544228 3636 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155540639 172089 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172089 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553479 173332 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 173332 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558428 173884 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 173884 0 AGTRA AT1 receptor Rat 7.6 pEC50 = 7.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553479 173332 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 173332 0 AGTR1 AT1 receptor Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543972 174170 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 174170 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 175205 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 175205 0 AGTRA AT1 receptor Rat 6.6 pEC50 = 6.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155556507 173641 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 173641 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
130762 97554 7 AGTR1 AT1 receptor Bovine 5.6 pEC50 = 5.6 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL274447 97554 7 AGTR1 AT1 receptor Bovine 5.6 pEC50 = 5.6 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
155568109 175191 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 175191 0 AGTRA AT1 receptor Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL77838 207970 1 AGTR1 AT1 receptor Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
CHEMBL77838 207970 1 AGTRA AT1 receptor Rat 8.5 pEC50 = 8.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155552475 173206 0 AGTR1 AT1 receptor Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 173206 0 AGTR1 AT1 receptor Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155558428 173884 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 173884 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155542907 172332 0 AGTRA AT1 receptor Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 172332 0 AGTRA AT1 receptor Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155560095 174077 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 174077 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155548506 172909 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 172909 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155569246 175335 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 175335 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155568804 175272 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 175272 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL2028943 202659 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155568318 175254 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 175254 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155543091 172335 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 172335 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 173428 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 173428 0 AGTR1 AT1 receptor Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 172089 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172089 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155544988 172597 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 172597 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155552475 173206 0 AGTRA AT1 receptor Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 173206 0 AGTRA AT1 receptor Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155565687 174736 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 174736 0 AGTR1 AT1 receptor Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556530 173666 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 173666 0 AGTRA AT1 receptor Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
1610 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3941 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3961 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
590 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
CHEMBL191 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
DB00678 2209 80 AGTR1 AT1 receptor Bovine 6.5 pEC50 = 6.5 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
155561376 174828 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 174828 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155563973 174515 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4574655 174515 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155541295 172167 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 172167 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
145925550 174625 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 174625 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155539838 172051 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172051 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
11943 3635 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3635 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3635 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540033 172046 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172046 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155520014 172391 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 172391 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL312754 204624 13 AGTRA AT1 receptor Rat 8.3 pEC50 = 8.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155548506 172909 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 172909 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155548148 172870 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 172870 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155554529 173788 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 173788 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 174899 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 174899 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558003 173848 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 173848 0 AGTRA AT1 receptor Rat 5.4 pEC50 = 5.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155541125 172121 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172121 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
70538373 174651 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 174651 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
154573825 175142 4 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175142 4 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155561477 174346 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 174346 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559104 173961 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 173961 0 AGTRA AT1 receptor Rat 7.4 pEC50 = 7.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155552475 173206 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 173206 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155560024 174045 0 AGTRA AT1 receptor Rat 4.4 pEC50 = 4.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174045 0 AGTRA AT1 receptor Rat 4.4 pEC50 = 4.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
11943 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
145925549 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
CHEMBL4438122 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
11943 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3635 0 AGTR1 AT1 receptor Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155542907 172332 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 172332 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155541125 172121 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172121 0 AGTR1 AT1 receptor Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155552475 173206 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 173206 0 AGTRA AT1 receptor Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155561376 174828 0 AGTR1 AT1 receptor Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 174828 0 AGTR1 AT1 receptor Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155560024 174045 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174045 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553098 173264 0 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 173264 0 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155553311 173287 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 173287 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155540547 171679 0 AGTRA AT1 receptor Rat 8.3 pEC50 = 8.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 171679 0 AGTRA AT1 receptor Rat 8.3 pEC50 = 8.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155548148 172870 0 AGTR1 AT1 receptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 172870 0 AGTR1 AT1 receptor Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155551762 173164 0 AGTRA AT1 receptor Rat 7.3 pEC50 = 7.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 173164 0 AGTRA AT1 receptor Rat 7.3 pEC50 = 7.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 172706 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 172706 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553930 174594 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 174594 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726675 98672 0 AGTR1 AT1 receptor Bovine 6.3 pEC50 = 6.3 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282566 98672 0 AGTR1 AT1 receptor Bovine 6.3 pEC50 = 6.3 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155558003 173848 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 173848 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
86727577 115233 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
CHEMBL3355127 115233 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
155555310 173514 0 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 173514 0 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155555310 173514 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 173514 0 AGTRA AT1 receptor Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
10533900 175122 2 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175122 2 AGTR1 AT1 receptor Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
90219582 115234 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
CHEMBL3355137 115234 0 AGTR1 AT1 receptor Human 5.3 pEC50 = 5.3 Binding
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
24892627 55145 3 AGTR1 AT1 receptor Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1460676 55145 3 AGTR1 AT1 receptor Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1621632 55145 3 AGTR1 AT1 receptor Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
155558059 173838 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 173838 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155552995 173266 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 173266 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL938 207999 18 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL77838 207970 1 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
CHEMBL312754 204624 13 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 175142 4 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175142 4 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
172198 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 400 40 AGTRA AT1 receptor Rat 8.2 pEC50 = 8.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726672 98607 0 AGTR1 AT1 receptor Bovine 6.2 pEC50 = 6.2 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282082 98607 0 AGTR1 AT1 receptor Bovine 6.2 pEC50 = 6.2 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
54726668 96556 0 AGTR1 AT1 receptor Bovine 5.2 pEC50 = 5.2 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL26875 96556 0 AGTR1 AT1 receptor Bovine 5.2 pEC50 = 5.2 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155559827 174070 0 AGTR1 AT1 receptor Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 174070 0 AGTR1 AT1 receptor Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155539838 172051 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172051 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547844 172853 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 172853 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553098 173264 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 173264 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155566196 174899 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 174899 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 175205 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 175205 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 174375 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 174375 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155568289 175279 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 175279 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155560463 174195 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 174195 0 AGTRA AT1 receptor Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 173230 0 AGTR1 AT1 receptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 173230 0 AGTR1 AT1 receptor Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
10533900 175122 2 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175122 2 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155544246 172521 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 172521 0 AGTRA AT1 receptor Rat 6.2 pEC50 = 6.2 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155520024 172401 0 AGTR1 AT1 receptor Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 172401 0 AGTR1 AT1 receptor Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155558784 173931 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 173931 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155543972 174170 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 174170 0 AGTR1 AT1 receptor Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2392353 203929 4 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155553098 173264 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 173264 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL938 207999 18 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155552886 173250 0 AGTR1 AT1 receptor Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 173250 0 AGTR1 AT1 receptor Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155552886 173250 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 173250 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
1588251 58743 10 AGTR1 AT1 receptor Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
CHEMBL1704271 58743 10 AGTR1 AT1 receptor Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
145925550 174625 0 AGTR1 AT1 receptor Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 174625 0 AGTR1 AT1 receptor Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155540328 172057 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172057 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155559104 173961 0 AGTR1 AT1 receptor Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 173961 0 AGTR1 AT1 receptor Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155540033 172046 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172046 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155541240 172172 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 172172 0 AGTRA AT1 receptor Rat 7.1 pEC50 = 7.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2028943 202659 0 AGTR1 AT1 receptor Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155539838 172051 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172051 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155552429 173311 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 173311 0 AGTRA AT1 receptor Rat 8.1 pEC50 = 8.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155540328 172057 0 AGTR1 AT1 receptor Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172057 0 AGTR1 AT1 receptor Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155563676 174498 0 AGTRA AT1 receptor Rat 6.1 pEC50 = 6.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 174498 0 AGTRA AT1 receptor Rat 6.1 pEC50 = 6.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155559120 173941 0 AGTRA AT1 receptor Rat 6.1 pEC50 = 6.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 173941 0 AGTRA AT1 receptor Rat 6.1 pEC50 = 6.1 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2370909 203471 0 AGTR1 AT1 receptor Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552429 173311 0 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 173311 0 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL312754 204624 13 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155541440 172176 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 172176 0 AGTRA AT1 receptor Rat 8.0 pEC50 = 8.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
172198 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 400 40 AGTR1 AT1 receptor Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726674 99027 0 AGTR1 AT1 receptor Bovine 7.1 pEC50 = 7.1 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
CHEMBL284877 99027 0 AGTR1 AT1 receptor Bovine 7.1 pEC50 = 7.1 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
11944 3636 0 AGTRA AT1 receptor Rat 6.0 pEC50 = 6.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3636 0 AGTRA AT1 receptor Rat 6.0 pEC50 = 6.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3636 0 AGTRA AT1 receptor Rat 6.0 pEC50 = 6.0 Binding
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL2370909 203471 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155558059 173838 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 173838 0 AGTR1 AT1 receptor Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155558784 173931 0 AGTRA AT1 receptor Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 173931 0 AGTRA AT1 receptor Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155569246 175335 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 175335 0 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
54726673 98523 0 AGTR1 AT1 receptor Bovine 5.0 pEC50 = 5.0 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28160 98523 0 AGTR1 AT1 receptor Bovine 5.0 pEC50 = 5.0 Binding
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
154573825 175142 4 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175142 4 AGTR1 AT1 receptor Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155553003 173230 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 173230 0 AGTRA AT1 receptor Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
10032858 29358 0 AGTR1 AT1 receptor Rabbit 10.4 pIC50 = 10.4 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL138690 29358 0 AGTR1 AT1 receptor Rabbit 10.4 pIC50 = 10.4 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
10032858 29358 0 AGTR1 AT1 receptor Rabbit 10.4 pIC50 = 10.4 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29358 0 AGTR1 AT1 receptor Rabbit 10.4 pIC50 = 10.4 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9895212 118884 0 AGTR1 AT1 receptor Human 10.3 pIC50 = 10.3 Binding
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 118884 0 AGTR1 AT1 receptor Human 10.3 pIC50 = 10.3 Binding
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
10417251 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL265797 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10417251 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10417251 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96217 0 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
3025727 183204 6 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48242 183204 6 AGTR1 AT1 receptor Rabbit 10.3 pIC50 = 10.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10349732 118003 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL341828 118003 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10032820 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10032820 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349732 118003 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118003 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10032820 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 116556 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10439848 118460 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343309 118460 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439848 118460 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 118460 0 AGTR1 AT1 receptor Rabbit 10.1 pIC50 = 10.1 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010071 116601 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339722 116601 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9829012 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44311455 102032 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102032 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102067 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102067 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 102348 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 102348 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311435 197595 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 197595 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 197657 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 197657 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 197695 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 197695 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 197756 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 197756 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 197770 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 197770 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 197793 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 197793 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9829012 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
73347893 91954 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 91954 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9829012 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24322 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19754061 102022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44309719 197427 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 197427 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10010071 116601 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 116601 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9829012 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24322 91884 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
9829012 91884 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 91884 0 AGTR1 AT1 receptor Human 10.0 pIC50 = 10 Binding
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9809961 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL316300 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439862 118022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL341934 118022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10010195 118434 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343142 118434 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
9809961 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9917295 102246 7 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 102246 7 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
9809961 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
9809961 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 106439 2 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439862 118022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118022 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 118434 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 118434 0 AGTR1 AT1 receptor Rabbit 10.0 pIC50 = 10.0 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10395394 31472 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL140708 31472 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10032851 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9809637 197425 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 197425 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10032851 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31472 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31472 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210588 119581 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 119581 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10032851 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16470 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113152 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
CHEMBL332576 113152 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
10395335 116336 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339256 116336 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10372451 116546 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339605 116546 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113152 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113152 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10395335 116336 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 116336 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372451 116546 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 116546 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372093 112026 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112026 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44314822 102237 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 102237 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10259411 30251 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139452 30251 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10485116 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL338101 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10462598 113397 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
CHEMBL332909 113397 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
10485116 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338101 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
10395076 167738 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL435811 167738 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10462598 113397 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 113397 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10485116 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116108 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10395076 167738 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 167738 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 167738 0 AGTR1 AT1 receptor Human 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 167738 0 AGTR1 AT1 receptor Human 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259411 30251 0 AGTR1 AT1 receptor Rabbit 9.9 pIC50 = 9.9 Binding