Ligand source activities (1 row/activity)





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16133225 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198.0 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
16133225 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198.0 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 None 38 Human Functional pEC50 = 9.3 9.3 -5 4
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
127030943 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127030943 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139282 None 0 Human Functional pEC50 = 9.0 9.0 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198.0 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 None 38 Rat Functional pEC50 = 8.9 8.9 -6 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
127029976 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029976 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139304 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
155564502 175364 None 0 Rat Functional pEC50 = 7 7.0 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175364 None 0 Rat Functional pEC50 = 7 7.0 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
11943 3875 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
145925549 3875 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4438122 3875 None 0 Rat Functional pEC50 = 8.0 8.0 14 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155558059 174787 None 0 Human Functional pEC50 = 7.0 7.0 -5 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174787 None 0 Human Functional pEC50 = 7.0 7.0 -5 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155541440 173122 None 0 Rat Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173122 None 0 Rat Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
11316919 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
11693 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
CHEMBL484929 3068 None 31 Human Functional pEC50 = 5.9 5.9 -2 8
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 451 4 0 4 5.3 Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F 10.6019/CHEMBL5442687
155541295 173114 None 0 Rat Functional pEC50 = 7.9 7.9 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173114 None 0 Rat Functional pEC50 = 7.9 7.9 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 173036 None 0 Rat Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 173036 None 0 Rat Functional pEC50 = 5.9 5.9 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2028943 211594 None 0 Human Functional pEC50 = 6.8 6.8 -1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155553930 175545 None 0 Rat Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175545 None 0 Rat Functional pEC50 = 4.8 4.8 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155540033 172993 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172993 None 0 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
127029977 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029977 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139305 None 0 Human Functional pEC50 = 8.7 8.7 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127031545 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127031545 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139283 None 0 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198.0 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 None 38 Human Functional pEC50 = 8.6 8.6 -5 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155541440 173122 None 0 Human Functional pEC50 = 8.6 8.6 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173122 None 0 Human Functional pEC50 = 8.6 8.6 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
10533900 176073 None 11 Rat Functional pEC50 = 7.7 7.7 10 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 176073 None 11 Rat Functional pEC50 = 7.7 7.7 10 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155556507 174590 None 0 Rat Functional pEC50 = 6.7 6.7 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174590 None 0 Rat Functional pEC50 = 6.7 6.7 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 175404 None 0 Rat Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175404 None 0 Rat Functional pEC50 = 6.7 6.7 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155559104 174910 None 0 Rat Functional pEC50 = 7.6 7.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174910 None 0 Rat Functional pEC50 = 7.6 7.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155554865 174458 None 0 Rat Functional pEC50 = 6.6 6.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174458 None 0 Rat Functional pEC50 = 6.6 6.6 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155540328 173004 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 173004 None 0 Human Functional pEC50 = 6.6 6.6 -3 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155553479 174282 None 0 Rat Functional pEC50 = 6.6 6.6 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174282 None 0 Rat Functional pEC50 = 6.6 6.6 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558003 174797 None 0 Rat Functional pEC50 = 5.6 5.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174797 None 0 Rat Functional pEC50 = 5.6 5.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547428 173719 None 0 Rat Functional pEC50 = 4.6 4.6 -22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173719 None 0 Rat Functional pEC50 = 4.6 4.6 -22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 175850 None 0 Rat Functional pEC50 = 4.6 4.6 -5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175850 None 0 Rat Functional pEC50 = 4.6 4.6 -5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558428 174833 None 0 Rat Functional pEC50 = 7.6 7.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174833 None 0 Rat Functional pEC50 = 7.6 7.6 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
11944 3876 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155552190 3876 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4544228 3876 None 0 Rat Functional pEC50 = 6.6 6.6 4 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL77838 218368 None 5 Rat Functional pEC50 = 8.5 8.5 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155552475 174156 None 0 Human Functional pEC50 = 8.4 8.4 9 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174156 None 0 Human Functional pEC50 = 8.4 8.4 9 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155542907 173280 None 0 Rat Functional pEC50 = 6.5 6.5 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173280 None 0 Rat Functional pEC50 = 6.5 6.5 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL2028943 211594 None 0 Rat Functional pEC50 = 7.5 7.5 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552475 174156 None 0 Rat Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174156 None 0 Rat Functional pEC50 = 6.5 6.5 -9 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556530 174615 None 0 Rat Functional pEC50 = 7.5 7.5 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174615 None 0 Rat Functional pEC50 = 7.5 7.5 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155561376 175779 None 0 Rat Functional pEC50 = 6.4 6.4 12 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 175779 None 0 Rat Functional pEC50 = 6.4 6.4 12 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155541125 173068 None 0 Rat Functional pEC50 = 7.4 7.4 6 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 173068 None 0 Rat Functional pEC50 = 7.4 7.4 6 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
24892627 55669 None 4 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1460676 55669 None 4 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1621632 55669 None 4 Human Functional pEC50 = 4.2 4.2 -5 2
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
155558059 174787 None 0 Rat Functional pEC50 = 7.2 7.2 5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174787 None 0 Rat Functional pEC50 = 7.2 7.2 5 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL938 218397 None 23 Rat Functional pEC50 = 8.2 8.2 -10 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL312754 213569 None 13 Rat Functional pEC50 = 8.2 8.2 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 176093 None 11 Rat Functional pEC50 = 8.2 8.2 8 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 176093 None 11 Rat Functional pEC50 = 8.2 8.2 8 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155560463 175144 None 0 Rat Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175144 None 0 Rat Functional pEC50 = 7.2 7.2 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 174180 None 0 Human Functional pEC50 = 7.2 7.2 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174180 None 0 Human Functional pEC50 = 7.2 7.2 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
10533900 176073 None 11 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 176073 None 11 Human Functional pEC50 = 6.2 6.2 -10 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL2392353 212873 None 5 Rat Functional pEC50 = 8.1 8.1 -50 3
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155553098 174214 None 0 Rat Functional pEC50 = 8.1 8.1 22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174214 None 0 Rat Functional pEC50 = 8.1 8.1 22 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
1588251 59295 None 5 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
CHEMBL1704271 59295 None 5 Human Functional pEC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
155540328 173004 None 0 Rat Functional pEC50 = 7.1 7.1 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 173004 None 0 Rat Functional pEC50 = 7.1 7.1 3 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155540033 172993 None 0 Rat Functional pEC50 = 7.1 7.1 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172993 None 0 Rat Functional pEC50 = 7.1 7.1 2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155539838 172998 None 0 Rat Functional pEC50 = 8.1 8.1 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172998 None 0 Rat Functional pEC50 = 8.1 8.1 1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2370909 212407 None 0 Rat Functional pEC50 = 7.0 7.0 7 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155558784 174880 None 0 Rat Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174880 None 0 Rat Functional pEC50 = 6.0 6.0 -2 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
154573825 176093 None 11 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 176093 None 11 Human Functional pEC50 = 7.0 7.0 -8 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155553003 174180 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174180 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
3025727 184186 None 6 Rabbit Functional pIC50 = 10.3 10.3 10000 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48242 184186 None 6 Rabbit Functional pIC50 = 10.3 10.3 10000 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971704 112448 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329616 112448 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
133031 100913 None 21 Human Functional pIC50 = 9.7 9.7 1 3
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL293511 100913 None 21 Human Functional pIC50 = 9.7 9.7 1 3
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
9892554 100248 None 5 Rabbit Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL288246 100248 None 5 Rabbit Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
14971715 168339 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL433646 168339 None 0 Rabbit Functional pIC50 = 9.7 9.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971716 14530 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120199 14530 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971706 209667 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92654 209667 None 0 Rabbit Functional pIC50 = 9.6 9.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 207302 None 16 Human Functional pIC50 = 9.5 9.5 -4 7
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
CHEMBL7550 207302 None 16 Human Functional pIC50 = 9.5 9.5 -4 7
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
14971698 209751 None 0 Rabbit Functional pIC50 = 9.5 9.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93226 209751 None 0 Rabbit Functional pIC50 = 9.5 9.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9827346 99791 None 3 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL284918 99791 None 3 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL34866 99791 None 3 Human Functional pIC50 = 9.4 9.4 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
9870652 70916 None 54 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
9870652.0 70916 None 54 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951143 70916 None 54 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
DB09279 70916 None 54 Rabbit Functional pIC50 = 9.4 9.4 15 2
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971720 114886 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL334145 114886 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971720 114886 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334145 114886 None 0 Rabbit Functional pIC50 = 9.4 9.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971705 209207 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90011 209207 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10325927 209344 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90774 209344 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971714 99244 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL281386 99244 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 207302 None 16 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
183134 207302 None 16 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
CHEMBL7550 207302 None 16 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
CHEMBL7550 207302 None 16 Rabbit Functional pIC50 = 9.3 9.3 -2 7
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
14971639 114196 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL332897 114196 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971639 114196 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL332897 114196 None 0 Rabbit Functional pIC50 = 9.3 9.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971702 209637 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92472 209637 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
4673492 4138 None 6 Human Functional pIC50 = 9.2 9.2 6 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.6019/CHEMBL5442687
8324 4138 None 6 Human Functional pIC50 = 9.2 9.2 6 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.6019/CHEMBL5442687
CHEMBL159096 4138 None 6 Human Functional pIC50 = 9.2 9.2 6 3
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.6019/CHEMBL5442687
14971710 209857 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93886 209857 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971717 14588 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120457 14588 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10369813 117044 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL338740 117044 None 0 Rabbit Functional pIC50 = 9.2 9.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534045 166573 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4278280 166573 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956763 163492 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL419483 163492 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971701 209878 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94002 209878 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971708 114658 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333800 114658 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10393717 116163 None 0 Rabbit Functional pIC50 = 9.1 9.1 524 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 116163 None 0 Rabbit Functional pIC50 = 9.1 9.1 524 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9914666 116734 None 0 Rabbit Functional pIC50 = 9.1 9.1 3388 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116734 None 0 Rabbit Functional pIC50 = 9.1 9.1 3388 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
14956739 208760 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87074 208760 None 0 Rabbit Functional pIC50 = 9.1 9.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192567 116716 None 4 Rabbit Functional pIC50 = 9.1 9.1 223 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116716 None 4 Rabbit Functional pIC50 = 9.1 9.1 223 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10140613 106152 None 0 Rabbit Functional pIC50 = 9.1 9.1 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313371 106152 None 0 Rabbit Functional pIC50 = 9.1 9.1 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956772 106003 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312913 106003 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192345 26244 None 3 Rabbit Functional pIC50 = 9 9.0 12022 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26244 None 3 Rabbit Functional pIC50 = 9 9.0 12022 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10326140 116715 None 0 Rabbit Functional pIC50 = 9 9.0 2884 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116715 None 0 Rabbit Functional pIC50 = 9 9.0 2884 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9807766 70908 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951136 70908 None 0 Rabbit Functional pIC50 = 9.0 9.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
60770 169602 None 14 Rabbit Functional pIC50 = 9.0 9.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL443269 169602 None 14 Rabbit Functional pIC50 = 9.0 9.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534141 167273 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4291216 167273 None 0 Human Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956757 67614 None 0 Rabbit Functional pIC50 = 8.9 8.9 831 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL19018 67614 None 0 Rabbit Functional pIC50 = 8.9 8.9 831 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971700 209916 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94221 209916 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9871638 70917 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951144 70917 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44320012 168026 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL431411 168026 None 0 Rabbit Functional pIC50 = 8.9 8.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
155542482 173230 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
CHEMBL4520827 173230 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
44213341 70901 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951129 70901 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
137532858 167186 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4289788 167186 None 0 Human Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971719 114856 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333978 114856 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971711 16561 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL123767 16561 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971707 209795 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93547 209795 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44213349 70907 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951135 70907 None 0 Rabbit Functional pIC50 = 8.8 8.8 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
20081627 92204 None 0 Human Functional pIC50 = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
CHEMBL24224 92204 None 0 Human Functional pIC50 = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
145981239 166704 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4280574 166704 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
131654 208861 None 10 Rabbit Functional pIC50 = 8.7 8.7 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 208861 None 10 Rabbit Functional pIC50 = 8.7 8.7 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956781 208631 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86314 208631 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9845644 208891 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87964 208891 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3941 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3961 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3961.0 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
590 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
DB00678 2347 None 64 Rabbit Functional pIC50 = 8 8.0 -19 11
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
10095589 115583 None 0 Rabbit Functional pIC50 = 8 8.0 851 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115583 None 0 Rabbit Functional pIC50 = 8 8.0 851 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
19939399 106220 None 0 Rabbit Functional pIC50 = 8 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313696 106220 None 0 Rabbit Functional pIC50 = 8 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10222835 208603 None 0 Rabbit Functional pIC50 = 8 8.0 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86084 208603 None 0 Rabbit Functional pIC50 = 8 8.0 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
142533975 167144 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4288964 167144 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44348352 16535 None 0 Rabbit Functional pIC50 = 7 7.0 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
CHEMBL123713 16535 None 0 Rabbit Functional pIC50 = 7 7.0 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
14971675 209427 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL91287 209427 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10048220 26197 None 0 Rabbit Functional pIC50 = 7 7.0 109 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 26197 None 0 Rabbit Functional pIC50 = 7 7.0 109 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
14956760 165595 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL424053 165595 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956777 208787 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87276 208787 None 0 Rabbit Functional pIC50 = 7 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
164611301 185124 None 0 Human Functional pIC50 = 5 5.0 -1 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4854916 185124 None 0 Human Functional pIC50 = 5 5.0 -1 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
1240113 29478 None 5 Human Functional pIC50 = 5 5.0 -3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
CHEMBL1384550 29478 None 5 Human Functional pIC50 = 5 5.0 -3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
164622816 185980 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4868159 185980 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
5411796 71951 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
CHEMBL1972216 71951 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
5740287 40208 None 5 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
CHEMBL1480264 40208 None 5 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
5738419 48468 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
CHEMBL1555793 48468 None 10 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
659124 38448 None 6 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
CHEMBL1463829 38448 None 6 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
1183382 23513 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
CHEMBL1333737 23513 None 9 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
1334532 36937 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
CHEMBL1451169 36937 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
10257526 112435 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329541 112435 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
5952109 72070 None 5 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
CHEMBL1976317 72070 None 5 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
2236648 28713 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL1377849 28713 None 6 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
6154033 108537 None 3 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
CHEMBL3199403 108537 None 3 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
4116022 51010 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
CHEMBL1578324 51010 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
19939367 106006 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312921 106006 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956804 106055 None 0 Rabbit Functional pIC50 = 8.0 8.0 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313222 106055 None 0 Rabbit Functional pIC50 = 8.0 8.0 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956792 106822 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314447 106822 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956754 157477 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL407827 157477 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956787 208805 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87363 208805 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44373246 168370 None 0 Bovine Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
CHEMBL433895 168370 None 0 Bovine Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
14956796 208257 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83182 208257 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10094520 24766 None 0 Rabbit Functional pIC50 = 6.0 6.0 11 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24766 None 0 Rabbit Functional pIC50 = 6.0 6.0 11 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
3504072 33638 None 7 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
CHEMBL1421427 33638 None 7 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
869765 38599 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
CHEMBL1464917 38599 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
16446215 47621 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
CHEMBL1546607 47621 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
5295671 35525 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
CHEMBL1438779 35525 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
1653161 40338 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
CHEMBL1481281 40338 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
14956759 208560 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85704 208560 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5335659 108519 None 4 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
CHEMBL3199216 108519 None 4 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
16446684 43009 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
CHEMBL1504077 43009 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
2426231 38134 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1461119 38134 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
53319274 57617 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1668000 57617 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
10027714 115501 None 0 Rabbit Functional pIC50 = 7.9 7.9 398 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 115501 None 0 Rabbit Functional pIC50 = 7.9 7.9 398 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
14956793 208766 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87129 208766 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956791 208799 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87341 208799 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956798 208867 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87798 208867 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951059 208887 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87942 208887 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
11744670 115318 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
CHEMBL334775 115318 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
14956742 208786 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87275 208786 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5187118 51877 None 4 Human Functional pIC50 = 4.9 4.9 -5 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
CHEMBL1585527 51877 None 4 Human Functional pIC50 = 4.9 4.9 -5 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
2313746 52135 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
CHEMBL1587672 52135 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
6917582 45687 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
CHEMBL1529805 45687 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
665535 45008 None 3 Human Functional pIC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1523699 45008 None 3 Human Functional pIC50 = 4.9 4.9 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
2812568 37218 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
CHEMBL1453309 37218 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
921731 52192 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1588194 52192 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
6173110 108216 None 2 Human Functional pIC50 = 4.9 4.9 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
CHEMBL3196139 108216 None 2 Human Functional pIC50 = 4.9 4.9 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
2351493 49799 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
CHEMBL1567294 49799 None 1 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
11467216 122668 None 0 Rabbit Functional pIC50 = 5.9 5.9 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL360220 122668 None 0 Rabbit Functional pIC50 = 5.9 5.9 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
135457059 51030 None 20 Human Functional pIC50 = 4.9 4.9 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
CHEMBL1578482 51030 None 20 Human Functional pIC50 = 4.9 4.9 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
2303647 28434 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
CHEMBL1375248 28434 None 5 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
11328757 208425 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
CHEMBL84573 208425 None 0 Rabbit Functional pIC50 = 7.9 7.9 -1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
9896251 98827 None 0 Human Functional pIC50 = 7.9 7.9 1 3
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
CHEMBL278176 98827 None 0 Human Functional pIC50 = 7.9 7.9 1 3
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
9958963 209690 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92821 209690 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971680 209830 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93735 209830 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57391456 70915 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951142 70915 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971687 14819 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120716 14819 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956812 106728 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314333 106728 None 0 Rabbit Functional pIC50 = 6.9 6.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
793621 26588 None 7 Human Functional pIC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
CHEMBL1361034 26588 None 7 Human Functional pIC50 = 4.9 4.9 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
2420694 33058 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL1416497 33058 None 3 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
1477595 44673 None 24 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
CHEMBL1520753 44673 None 24 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
1336836 33017 None 6 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
CHEMBL1416155 33017 None 6 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
135489943 107922 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
CHEMBL3192625 107922 None 2 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
1139588 38372 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1463168 38372 None 8 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
6873170 108521 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
CHEMBL3199234 108521 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
804442 53843 None 36 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
CHEMBL1604367 53843 None 36 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
929469 46576 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1537991 46576 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
3244543 201952 None 23 Human Functional pIC50 = 4.9 4.9 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
CHEMBL591834 201952 None 23 Human Functional pIC50 = 4.9 4.9 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
43001 52801 None 18 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
CHEMBL1594894 52801 None 18 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
788616 53090 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
CHEMBL1597563 53090 None 6 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
2998385 25162 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1347643 25162 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
9549748 23247 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
CHEMBL1331656 23247 None 7 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
2939261 22122 None 4 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1322052 22122 None 4 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
14956799 106955 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314590 106955 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956766 107035 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315128 107035 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956813 208797 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87330 208797 None 0 Rabbit Functional pIC50 = 7.9 7.9 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44211606 101267 None 0 Bovine Functional pIC50 = 6.9 6.9 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295905 101267 None 0 Bovine Functional pIC50 = 6.9 6.9 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44246747 55853 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1521291 55853 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1623128 55853 None 0 Human Functional pIC50 = 4.9 4.9 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
135501733 37071 None 14 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
CHEMBL1452116 37071 None 14 Human Functional pIC50 = 4.9 4.9 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
2898747 36776 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1449757 36776 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
788619 45581 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
CHEMBL1528883 45581 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
3648468 51522 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
CHEMBL1582697 51522 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
135419079 30234 None 4 Human Functional pIC50 = 4.8 4.8 -1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
CHEMBL1390716 30234 None 4 Human Functional pIC50 = 4.8 4.8 -1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
877472 36686 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
CHEMBL1449035 36686 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
902793 43227 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1505893 43227 None 12 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
67903280 186308 None 0 Human Functional pIC50 = 7.8 7.8 4 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4872989 186308 None 0 Human Functional pIC50 = 7.8 7.8 4 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
44355662 26470 None 0 Rabbit Functional pIC50 = 7.8 7.8 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26470 None 0 Rabbit Functional pIC50 = 7.8 7.8 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10004013 116757 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
CHEMBL337217 116757 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
14956744 208621 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86255 208621 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1726745 23938 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
CHEMBL1337184 23938 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
5731702 186758 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
CHEMBL488140 186758 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
2476054 47911 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
CHEMBL1549272 47911 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
2458676 31418 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
CHEMBL1402558 31418 None 2 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
2221657 34524 None 8 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
CHEMBL1428950 34524 None 8 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
44342039 10295 None 0 Human Functional pIC50 = 6.8 6.8 -21 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL116170 10295 None 0 Human Functional pIC50 = 6.8 6.8 -21 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
2426360 46901 None 3 Human Functional pIC50 = 4.8 4.8 -8 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
CHEMBL1540808 46901 None 3 Human Functional pIC50 = 4.8 4.8 -8 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
9653239 107704 None 4 Human Functional pIC50 = 5.8 5.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
CHEMBL3190198 107704 None 4 Human Functional pIC50 = 5.8 5.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
5730138 34803 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1431014 34803 None 9 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
12005285 53080 None 5 Human Functional pIC50 = 5.8 5.8 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1597454 53080 None 5 Human Functional pIC50 = 5.8 5.8 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
1767917 31244 None 8 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
CHEMBL1401122 31244 None 8 Human Functional pIC50 = 4.8 4.8 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
14956806 106986 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314810 106986 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956768 107027 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315077 107027 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956745 208727 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86906 208727 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951062 208849 None 0 Rabbit Functional pIC50 = 7.8 7.8 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87669 208849 None 0 Rabbit Functional pIC50 = 7.8 7.8 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
131590 20710 None 37 Human Functional pIC50 = 7.8 7.8 1 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.6019/CHEMBL5442687
CHEMBL130896 20710 None 37 Human Functional pIC50 = 7.8 7.8 1 2
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.6019/CHEMBL5442687
14971694 14698 None 0 Rabbit Functional pIC50 = 6.8 6.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120605 14698 None 0 Rabbit Functional pIC50 = 6.8 6.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44355660 21564 None 0 Rabbit Functional pIC50 = 6.8 6.8 89 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21564 None 0 Rabbit Functional pIC50 = 6.8 6.8 89 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
10410730 24626 None 0 Rabbit Functional pIC50 = 5.8 5.8 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24626 None 0 Rabbit Functional pIC50 = 5.8 5.8 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
2898434 53884 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1604741 53884 None 10 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
3532334 42366 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
CHEMBL1498428 42366 None 8 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
2640418 22155 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1322344 22155 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
5687785 108460 None 1 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL3198576 108460 None 1 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
5735740 41664 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1491932 41664 None 7 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
2320855 36562 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
CHEMBL1448161 36562 None 4 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
5091521 25303 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
CHEMBL1348954 25303 None 5 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
2121806 42079 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
CHEMBL1495849 42079 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
2733001 29305 None 2 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
CHEMBL1382939 29305 None 2 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
25162518 39865 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1477291 39865 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
14956784 106613 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314179 106613 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956764 208535 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85541 208535 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44355628 24914 None 0 Rabbit Functional pIC50 = 6.8 6.8 5 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24914 None 0 Rabbit Functional pIC50 = 6.8 6.8 5 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10095493 26056 None 0 Rabbit Functional pIC50 = 6.8 6.8 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 26056 None 0 Rabbit Functional pIC50 = 6.8 6.8 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
1336623 38298 None 15 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
CHEMBL1462517 38298 None 15 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
2165745 34689 None 6 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1430172 34689 None 6 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
659805 21973 None 4 Human Functional pIC50 = 4.8 4.8 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
CHEMBL1320678 21973 None 4 Human Functional pIC50 = 4.8 4.8 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
135415440 201506 None 12 Human Functional pIC50 = 5.8 5.8 -10 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
CHEMBL586135 201506 None 12 Human Functional pIC50 = 5.8 5.8 -10 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
579121 49146 None 7 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 4 1 4 4.7 COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 nan
CHEMBL1561907 49146 None 7 Human Functional pIC50 = 4.8 4.8 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 4 1 4 4.7 COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 nan
24983202 27822 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 7 1 6 2.9 CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
CHEMBL1371002 27822 None 3 Human Functional pIC50 = 4.8 4.8 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 7 1 6 2.9 CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
14971686 15255 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 507 10 1 8 5.2 CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121125 15255 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 507 10 1 8 5.2 CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10414429 116061 None 0 Rabbit Functional pIC50 = 7.8 7.8 363 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 116061 None 0 Rabbit Functional pIC50 = 7.8 7.8 363 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10322211 169575 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1021/jm00078a013
CHEMBL442963 169575 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 464 6 1 7 4.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 10.1021/jm00078a013
14956741 107110 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315615 107110 None 0 Rabbit Functional pIC50 = 7.8 7.8 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44292094 101499 None 0 Bovine Functional pIC50 = 6.8 6.8 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 585 9 1 9 6.4 CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL297583 101499 None 0 Bovine Functional pIC50 = 6.8 6.8 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 585 9 1 9 6.4 CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
23205 116984 None 33 Human Functional pIC50 = 4.7 4.7 -7 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 0 1 4 1.2 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 nan
CHEMBL338474 116984 None 33 Human Functional pIC50 = 4.7 4.7 -7 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 0 1 4 1.2 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 nan
24981067 45217 None 3 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 8 1 7 1.8 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
CHEMBL1525764 45217 None 3 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 8 1 7 1.8 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 nan
768473 49985 None 4 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 267 6 0 2 3.9 CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL1568922 49985 None 4 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 267 6 0 2 3.9 CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 nan
4799115 24538 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 332 3 2 4 4.1 O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F nan
CHEMBL1342423 24538 None 5 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 332 3 2 4 4.1 O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F nan
11957260 33021 None 5 Human Functional pIC50 = 5.7 5.7 5 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 6 2 10 3.3 O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
CHEMBL1416184 33021 None 5 Human Functional pIC50 = 5.7 5.7 5 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 6 2 10 3.3 O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
1610 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3941 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3961 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
3961.0 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
590 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
CHEMBL191 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
DB00678 2347 None 64 Rat Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00057a009
1610 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3941 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
590 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.7 7.7 -19 11
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
10069786 169204 None 0 Human Functional pIC50 = 6.7 6.7 -19 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL439968 169204 None 0 Human Functional pIC50 = 6.7 6.7 -19 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
10393397 22807 None 0 Rabbit Functional pIC50 = 5.7 5.7 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 22807 None 0 Rabbit Functional pIC50 = 5.7 5.7 6 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
568849 31729 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 313 7 0 5 3.0 O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1405657 31729 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 313 7 0 5 3.0 O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
5720743 108306 None 9 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 nan
CHEMBL3197070 108306 None 9 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 nan
761850 38805 None 7 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.3 Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] nan
CHEMBL1466556 38805 None 7 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.3 Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] nan
142534050 167062 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 545 11 1 7 5.2 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4287379 167062 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 545 11 1 7 5.2 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971712 99657 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 402 8 3 5 3.9 CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL283975 99657 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 402 8 3 5 3.9 CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956756 208829 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87513 208829 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 529 8 1 7 5.0 CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
20081627 92204 None 0 Rabbit Functional pIC50 = 8.7 8.7 -1 2
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL24224 92204 None 0 Rabbit Functional pIC50 = 8.7 8.7 -1 2
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459871 92582 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL2079791 92582 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL24319 92582 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 573 8 1 8 4.2 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O 10.1016/S0960-894X(01)80348-6
44459655 93278 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL2079788 93278 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL24478 93278 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 575 9 1 8 4.3 CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
44459835 168142 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL2079790 168142 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL432271 168142 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 587 8 1 8 4.5 CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459654 168213 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL2079787 168213 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL432847 168213 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 601 8 1 8 4.9 CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O 10.1016/S0960-894X(01)80348-6
22942227 70902 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 9 3.5 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951130 70902 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 9 3.5 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
22942226 70903 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 554 10 2 8 2.8 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951131 70903 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 554 10 2 8 2.8 CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
142534121 166817 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 11 1 7 5.4 CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4282931 166817 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 11 1 7 5.4 CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971638 114939 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.5 CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334192 114939 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.5 CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9845644 208891 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87964 208891 None 0 Rabbit Functional pIC50 = 8.7 8.7 5 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956779 68685 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL19202 68685 None 0 Rabbit Functional pIC50 = 8.7 8.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 445 8 1 7 4.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
142533975 167144 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4288964 167144 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
155517399 170284 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 10 1 6 6.8 CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.12.043
CHEMBL4444760 170284 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 10 1 6 6.8 CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.12.043
14971699 112846 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL330571 112846 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44213343 70898 None 29 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 485 9 1 7 3.4 CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951126 70898 None 29 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 485 9 1 7 3.4 CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
9935106 65303 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL18287 65303 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44213346 70904 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 9 1 7 4.3 CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951132 70904 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 9 1 7 4.3 CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971709 15353 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 553 11 2 9 5.3 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121416 15353 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 553 11 2 9 5.3 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57401930 70892 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 500 11 1 8 4.3 CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951120 70892 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 500 11 1 8 4.3 CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44213342 70895 None 18 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 458 9 2 7 3.4 CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951123 70895 None 18 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 458 9 2 7 3.4 CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971713 168086 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL431887 168086 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57393227 70906 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 543 9 1 8 3.9 CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951134 70906 None 0 Rabbit Functional pIC50 = 8.6 8.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 543 9 1 8 3.9 CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
108185 1614 None 50 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
586 1614 None 50 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
CHEMBL907 1614 None 50 Rabbit Functional pIC50 = 8.6 8.6 -3 5
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00075a014
14971697 111604 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.4 CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327982 111604 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.4 CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10298977 208781 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87239 208781 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 9 1 7 4.9 CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
131654 208861 None 10 Rabbit Functional pIC50 = 8.5 8.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 208861 None 10 Rabbit Functional pIC50 = 8.5 8.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1481 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
3749 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
3749.0 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
589 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
6908 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
CHEMBL1513 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
DB01029 2066 None 66 Human Functional pIC50 = 8.5 8.5 -2 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.6019/CHEMBL5442687
14971683 14868 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 536 11 1 8 5.8 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120750 14868 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 536 11 1 8 5.8 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971692 113016 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.7 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL331078 113016 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.7 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10026868 23867 None 0 Rabbit Functional pIC50 = 7.7 7.7 331 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 23867 None 0 Rabbit Functional pIC50 = 7.7 7.7 331 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
14956766 107035 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315128 107035 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2540 4402 None 68 Rabbit Functional pIC50 = 6.7 6.7 -28 28
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1014 4402 None 68 Rabbit Functional pIC50 = 6.7 6.7 -28 28
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10409549 116042 None 0 Rabbit Functional pIC50 = 6.7 6.7 104 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 116042 None 0 Rabbit Functional pIC50 = 6.7 6.7 104 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10345459 116834 None 0 Rabbit Functional pIC50 = 6.7 6.7 43 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 116834 None 0 Rabbit Functional pIC50 = 6.7 6.7 43 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
25163176 44106 None 3 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 431 8 0 6 2.8 COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 nan
CHEMBL1514866 44106 None 3 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 431 8 0 6 2.8 COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 nan
3116640 20414 None 9 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 542 6 0 7 2.1 O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1306605 20414 None 9 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 542 6 0 7 2.1 O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
1653162 50011 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 3 3 5 1.7 COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 nan
CHEMBL1569107 50011 None 6 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 3 3 5 1.7 COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 nan
11957180 22752 None 5 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 7 2 10 3.7 O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
CHEMBL1327721 22752 None 5 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 7 2 10 3.7 O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 nan
11957209 43048 None 5 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1504429 43048 None 5 Human Functional pIC50 = 5.7 5.7 6 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
9550611 49778 None 5 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 6 1 10 3.3 CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1567159 49778 None 5 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 403 6 1 10 3.3 CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
780302 31891 None 4 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 3 2 4 3.9 NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 nan
CHEMBL1407100 31891 None 4 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 3 2 4 3.9 NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 nan
14971681 111583 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327862 111583 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956771 208811 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87392 208811 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956750 208543 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85596 208543 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2412928 21724 None 4 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 500 7 1 11 1.5 Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O nan
CHEMBL1318653 21724 None 4 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 500 7 1 11 1.5 Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O nan
6418891 22824 None 10 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 401 3 0 4 5.7 FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 nan
CHEMBL1328168 22824 None 10 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 401 3 0 4 5.7 FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 nan
2815589 41687 None 2 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 5 2 3 2.2 NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 nan
CHEMBL1492089 41687 None 2 Human Functional pIC50 = 4.7 4.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 5 2 3 2.2 NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 nan
16436605 38471 None 8 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 nan
CHEMBL1464024 38471 None 8 Human Functional pIC50 = 5.7 5.7 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 nan
11159916 123918 None 3 Rabbit Functional pIC50 = 4.7 4.7 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
CHEMBL362550 123918 None 3 Rabbit Functional pIC50 = 4.7 4.7 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
442142 185576 None 17 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 1 0 5 1.8 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 nan
CHEMBL486196 185576 None 17 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 1 0 5 1.8 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 nan
53317942 57615 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1667999 57615 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 444 7 1 7 3.3 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
14971695 14877 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.5 CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120762 14877 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.5 CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44292181 101218 None 0 Bovine Functional pIC50 = 7.7 7.7 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295529 101218 None 0 Bovine Functional pIC50 = 7.7 7.7 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
9982177 26507 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL136028 26507 None 0 Rabbit Functional pIC50 = 7.7 7.7 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10275744 208576 None 0 Rabbit Functional pIC50 = 7.7 7.7 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85876 208576 None 0 Rabbit Functional pIC50 = 7.7 7.7 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 451 8 1 7 4.3 CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2939837 37283 None 4 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 2 3 4 3.9 CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1453857 37283 None 4 Human Functional pIC50 = 4.7 4.7 -4 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 2 3 4 3.9 CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
800048 24493 None 22 Human Functional pIC50 = 5.7 5.7 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 252 2 0 4 2.6 CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 nan
CHEMBL1342053 24493 None 22 Human Functional pIC50 = 5.7 5.7 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 252 2 0 4 2.6 CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 nan
972880 194472 None 5 Human Functional pIC50 = 5.7 5.7 -6 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
CHEMBL528694 194472 None 5 Human Functional pIC50 = 5.7 5.7 -6 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
9660957 72781 None 8 Human Functional pIC50 = 5.7 5.7 -1 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
CHEMBL1999049 72781 None 8 Human Functional pIC50 = 5.7 5.7 -1 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
1472225 24752 None 9 Human Functional pIC50 = 5.7 5.7 -5 7
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24752 None 9 Human Functional pIC50 = 5.7 5.7 -5 7
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
3734285 46628 None 14 Human Functional pIC50 = 4.7 4.7 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 7 1 4 4.8 CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 nan
CHEMBL1538399 46628 None 14 Human Functional pIC50 = 4.7 4.7 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 7 1 4 4.8 CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 nan
5335941 107965 None 5 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 2 2 2 3.4 CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 nan
CHEMBL3193181 107965 None 5 Human Functional pIC50 = 4.7 4.7 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 2 2 2 3.4 CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 nan
9590741 107904 None 3 Human Functional pIC50 = 5.6 5.6 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 nan
CHEMBL3192432 107904 None 3 Human Functional pIC50 = 5.6 5.6 -2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 nan
2539399 39902 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 4 2 5 2.4 Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 nan
CHEMBL1477553 39902 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 4 2 5 2.4 Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 nan
11159916 123918 None 3 Rabbit Functional pIC50 = 4.6 4.6 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
CHEMBL362550 123918 None 3 Rabbit Functional pIC50 = 4.6 4.6 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 197 4 1 4 1.1 O=C(O)c1cccc(CO[N+](=O)[O-])c1 10.1021/jm049681p
2283939 44428 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 404 8 1 6 3.7 Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] nan
CHEMBL1518619 44428 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 404 8 1 6 3.7 Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] nan
14971685 156610 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.5 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL406791 156610 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 582 11 1 7 7.5 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10113613 106815 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 7 1 7 4.0 CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314436 106815 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 7 1 7 4.0 CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956797 208877 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87885 208877 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10048776 115286 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 438 6 1 5 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL334622 115286 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 438 6 1 5 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 10.1021/jm00078a013
1096078 49634 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 1 4 4.2 COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 nan
CHEMBL1566084 49634 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 1 4 4.2 COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 nan
2645512 32468 None 3 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 6 0 6 3.3 O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1411597 32468 None 3 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 6 0 6 3.3 O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
2171031 39184 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 8 1 6 1.7 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1469682 39184 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 8 1 6 1.7 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
889369 54502 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 3 4 3.0 CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1609718 54502 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 3 4 3.0 CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
2905495 20027 None 10 Human Functional pIC50 = 5.6 5.6 1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 4 1 9 3.3 Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C nan
CHEMBL1303426 20027 None 10 Human Functional pIC50 = 5.6 5.6 1 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 4 1 9 3.3 Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C nan
3239204 54033 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 7 4.0 COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 nan
CHEMBL1605977 54033 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 7 4.0 COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 nan
2848041 22089 None 3 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 nan
CHEMBL1321754 22089 None 3 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 nan
1472220 41909 None 10 Human Functional pIC50 = 5.6 5.6 3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 nan
CHEMBL1494120 41909 None 10 Human Functional pIC50 = 5.6 5.6 3 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 nan
135636104 44089 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 217 3 1 5 2.7 O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 nan
CHEMBL1514691 44089 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 217 3 1 5 2.7 O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 nan
936147 52686 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 6 0 4 4.3 CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 nan
CHEMBL1593888 52686 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 6 0 4 4.3 CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 nan
8480343 43925 None 3 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 2 5 2.2 Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 nan
CHEMBL1512236 43925 None 3 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 330 4 2 5 2.2 Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 nan
2632794 22769 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 312 5 0 4 3.5 O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1327815 22769 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 312 5 0 4 3.5 O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 nan
14956786 107021 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 433 9 2 8 2.8 CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315012 107021 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 433 9 2 8 2.8 CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
3941 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
3961 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
3961.0 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
590 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
CHEMBL191 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
DB00678 2347 None 64 Human Functional pIC50 = 7.6 7.6 -10 11
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.6019/CHEMBL5442687
10250898 118552 None 0 Rabbit Functional pIC50 = 6.6 6.6 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 118552 None 0 Rabbit Functional pIC50 = 6.6 6.6 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
6908540 107804 None 16 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 305 5 1 5 1.9 O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 nan
CHEMBL3191392 107804 None 16 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 305 5 1 5 1.9 O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 nan
2739277 29699 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 2 5 4.3 O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 nan
CHEMBL1386393 29699 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 364 4 2 5 4.3 O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 nan
135478724 35140 None 25 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 1 1 2 2.9 O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 nan
CHEMBL1434292 35140 None 25 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 1 1 2 2.9 O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 nan
3118020 47500 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 6 0 7 1.7 CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O nan
CHEMBL1545561 47500 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 6 0 7 1.7 CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O nan
164613537 185232 None 0 Human Functional pIC50 = 7.6 7.6 21 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4856425 185232 None 0 Human Functional pIC50 = 7.6 7.6 21 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
10025873 115598 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 433 4 0 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 10.1021/jm00078a013
CHEMBL335323 115598 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 433 4 0 6 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 10.1021/jm00078a013
14956765 208880 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 6 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87890 208880 None 0 Rabbit Functional pIC50 = 6.6 6.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 6 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
773605 45192 None 20 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 2 3 3.3 Fc1ccc(NC(S)=Nc2nccs2)cc1 nan
CHEMBL1525546 45192 None 20 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 2 3 3.3 Fc1ccc(NC(S)=Nc2nccs2)cc1 nan
3754656 47946 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 8 1 6 2.6 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 nan
CHEMBL1549587 47946 None 5 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 8 1 6 2.6 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 nan
933895 22726 None 24 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 166 2 2 5 1.0 CC(C)c1nc(C#N)c(NN)o1 nan
CHEMBL1327546 22726 None 24 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 166 2 2 5 1.0 CC(C)c1nc(C#N)c(NN)o1 nan
42600949 54402 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
CHEMBL1608922 54402 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
CHEMBL2131333 54402 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 385 4 1 5 3.9 CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O nan
2811327 34333 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 4 2 2 4.0 CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 nan
CHEMBL1427235 34333 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 4 2 2 4.0 CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 nan
2896074 45674 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 491 3 2 7 5.2 O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 nan
CHEMBL1529705 45674 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 491 3 2 7 5.2 O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 nan
2813088 48560 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 290 3 2 5 2.9 Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 nan
CHEMBL1556712 48560 None 2 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 290 3 2 5 2.9 Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 nan
6887818 108193 None 3 Human Functional pIC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 430 4 1 4 4.8 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 nan
CHEMBL3195898 108193 None 3 Human Functional pIC50 = 5.6 5.6 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 430 4 1 4 4.8 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 nan
2883150 50963 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 9 2 7 2.7 CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
CHEMBL1577988 50963 None 11 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 9 2 7 2.7 CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
14956788 107086 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 2 8 2.9 CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315469 107086 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 2 8 2.9 CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2321121 55470 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1412385 55470 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1619819 55470 None 0 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 557 7 1 5 6.3 O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 nan
2378336 36133 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 6 2 4 2.5 COc1ccc(C(=O)CNc2ccccc2CO)cc1 nan
CHEMBL1444275 36133 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 6 2 4 2.5 COc1ccc(C(=O)CNc2ccccc2CO)cc1 nan
3118009 44659 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.4 O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1520643 44659 None 8 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.4 O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
135492609 108312 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 521 2 1 7 3.6 CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 nan
CHEMBL3197135 108312 None 2 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 521 2 1 7 3.6 CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 nan
183134 207302 None 16 Bovine Functional pIC50 = 7.6 7.6 -134 7
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL7550 207302 None 16 Bovine Functional pIC50 = 7.6 7.6 -134 7
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
11527144 179211 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL297425 179211 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47177 179211 None 0 Bovine Functional pIC50 = 7.6 7.6 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956749 208676 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86613 208676 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.8 CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956803 208743 None 0 Rabbit Functional pIC50 = 7.6 7.6 10 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86986 208743 None 0 Rabbit Functional pIC50 = 7.6 7.6 10 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956767 208845 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 483 7 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87650 208845 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 483 7 1 7 4.5 O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54500223 70896 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 444 8 2 7 3.0 CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951124 70896 None 0 Rabbit Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 444 8 2 7 3.0 CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
324450 40928 None 21 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 219 3 2 3 1.4 O=C(CCl)NNc1cccc(Cl)n1 nan
CHEMBL1486528 40928 None 21 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 219 3 2 3 1.4 O=C(CCl)NNc1cccc(Cl)n1 nan
3103390 44853 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 7 2.1 O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1522230 44853 None 7 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 7 2.1 O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
1231596 35859 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 4 1 7 4.2 COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O nan
CHEMBL1441794 35859 None 10 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 4 1 7 4.2 COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O nan
9653430 71771 None 2 Human Functional pIC50 = 4.6 4.6 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 3 2 3 4.2 COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 nan
CHEMBL1966283 71771 None 2 Human Functional pIC50 = 4.6 4.6 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 3 2 3 4.2 COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 nan
161167 95544 None 32 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 284 3 1 3 3.0 O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 nan
CHEMBL257286 95544 None 32 Human Functional pIC50 = 5.6 5.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 284 3 1 3 3.0 O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 nan
3235730 52156 None 8 Human Functional pIC50 = 4.6 4.6 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 432 8 1 9 3.4 CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N nan
CHEMBL1587831 52156 None 8 Human Functional pIC50 = 4.6 4.6 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 432 8 1 9 3.4 CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N nan
793994 107758 None 4 Human Functional pIC50 = 5.6 5.6 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 2 1 4 4.9 Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 nan
CHEMBL3190827 107758 None 4 Human Functional pIC50 = 5.6 5.6 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 304 2 1 4 4.9 Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 nan
135444079 39154 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 1 1 2 3.7 Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 nan
CHEMBL1469448 39154 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 1 1 2 3.7 Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 nan
2412176 54921 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 5 1 3 3.1 COc1ccc(C(=O)CNc2cccc(F)c2)cc1 nan
CHEMBL1613520 54921 None 4 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 5 1 3 3.1 COc1ccc(C(=O)CNc2cccc(F)c2)cc1 nan
10411101 165760 None 0 Rabbit Functional pIC50 = 7.6 7.6 676 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 165760 None 0 Rabbit Functional pIC50 = 7.6 7.6 676 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
10371403 66943 None 18 Rabbit Functional pIC50 = 5.6 5.6 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL186572 66943 None 18 Rabbit Functional pIC50 = 5.6 5.6 - 1
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
3119388 47350 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 556 7 0 7 2.5 O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1544373 47350 None 9 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 556 7 0 7 2.5 O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
4691872 47272 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 372 5 1 6 2.8 COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 nan
CHEMBL1543866 47272 None 1 Human Functional pIC50 = 4.6 4.6 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 372 5 1 6 2.8 COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 nan
135557876 108311 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 4 3 6 2.4 Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O nan
CHEMBL3197126 108311 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 4 3 6 2.4 Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O nan
2767330 96427 None 21 Human Functional pIC50 = 5.5 5.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 1 0 3 3.7 Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
CHEMBL261693 96427 None 21 Human Functional pIC50 = 5.5 5.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 1 0 3 3.7 Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
852940 49855 None 9 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 2 1 5 3.0 CCc1cc2c(O)nc(-c3ccccn3)nc2s1 nan
CHEMBL1567827 49855 None 9 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 2 1 5 3.0 CCc1cc2c(O)nc(-c3ccccn3)nc2s1 nan
3138587 34528 None 1 Human Functional pIC50 = 4.5 4.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 391 6 5 10 -2.3 CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 nan
CHEMBL1428985 34528 None 1 Human Functional pIC50 = 4.5 4.5 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 391 6 5 10 -2.3 CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 nan
1472222 28698 None 9 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 414 7 1 5 3.6 COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
CHEMBL1377737 28698 None 9 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 414 7 1 5 3.6 COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
135443160 31725 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 435 2 1 5 4.5 O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 nan
CHEMBL1405610 31725 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 435 2 1 5 4.5 O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 nan
2920316 37685 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 446 9 1 6 3.6 Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] nan
CHEMBL1457414 37685 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 446 9 1 6 3.6 Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] nan
4146306 25227 None 1 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 2 1 4 3.3 O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 nan
CHEMBL1348215 25227 None 1 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 2 1 4 3.3 O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 nan
1610 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
3941 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
3961 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
3961.0 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
590 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
DB00678 2347 None 64 Rabbit Functional pIC50 = 8.5 8.5 -19 11
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)80348-6
20081616 92292 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 500 6 2 8 5.3 Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL24266 92292 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 500 6 2 8 5.3 Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459656 99680 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL2079789 99680 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
CHEMBL284140 99680 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 561 8 1 8 3.9 CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80348-6
14956814 208258 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 7 4.8 CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83194 208258 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 7 4.8 CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971703 107144 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL315878 107144 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956761 106027 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313025 106027 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 494 9 1 8 4.3 CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956778 208751 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87057 208751 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 3.9 CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44320509 208796 None 0 Rabbit Functional pIC50 = 8.5 8.5 1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm0603163
CHEMBL87327 208796 None 0 Rabbit Functional pIC50 = 8.5 8.5 1 2
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 465 6 2 6 5.5 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 10.1021/jm0603163
22942224 70909 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 583 11 1 9 3.9 CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951137 70909 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 583 11 1 9 3.9 CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44292471 157644 None 0 Bovine Functional pIC50 = 8.5 8.5 - 1
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 563 10 3 8 5.0 CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
CHEMBL408033 157644 None 0 Bovine Functional pIC50 = 8.5 8.5 - 1
Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.
ChEMBL 563 10 3 8 5.0 CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80366-2
54277224 70905 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 540 9 1 8 3.1 CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951133 70905 None 0 Rabbit Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 540 9 1 8 3.1 CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971718 15539 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 388 7 3 5 3.5 CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL121847 15539 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 388 7 3 5 3.5 CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956753 107126 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315776 107126 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 527 9 1 7 5.9 CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971721 113246 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 544 8 2 6 6.3 O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
CHEMBL331475 113246 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 544 8 2 6 6.3 O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
4673492 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
8324 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
CHEMBL159096 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 10.1021/jm9504722
14971689 12212 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 10 1 7 5.4 CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL118431 12212 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 10 1 7 5.4 CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44211605 170863 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 10 1 10 5.0 CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44526 170863 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 10 1 10 5.0 CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956809 106248 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 656 15 1 9 6.5 CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313837 106248 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 656 15 1 9 6.5 CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
132562 99737 None 5 Guinea pig Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm9504722
CHEMBL284536 99737 None 5 Guinea pig Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1021/jm9504722
57403666 70894 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 9 1 8 3.5 CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O 10.1016/j.bmcl.2011.12.116
CHEMBL1951122 70894 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 9 1 8 3.5 CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O 10.1016/j.bmcl.2011.12.116
57396698 70899 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 513 11 1 7 4.2 CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951127 70899 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 513 11 1 7 4.2 CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
6918269 98523 None 10 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL275875 98523 None 10 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295959 98523 None 10 Bovine Functional pIC50 = 7.5 7.5 -5 2
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10027636 24602 None 0 Rabbit Functional pIC50 = 7.5 7.5 70 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 24602 None 0 Rabbit Functional pIC50 = 7.5 7.5 70 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
135406019 24041 None 8 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 2 1 3 3.0 CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 nan
CHEMBL1338100 24041 None 8 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 2 1 3 3.0 CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 nan
3395163 29845 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 441 11 1 7 3.5 CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1387520 29845 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 441 11 1 7 3.5 CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
6603703 208 None 8 Human Functional pIC50 = 5.5 5.5 -1047 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442687
9637 208 None 8 Human Functional pIC50 = 5.5 5.5 -1047 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442687
CHEMBL291143 208 None 8 Human Functional pIC50 = 5.5 5.5 -1047 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 329 2 3 4 3.3 NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 10.6019/CHEMBL5442687
16012865 23349 None 7 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 6 1 7 2.6 CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
CHEMBL1332454 23349 None 7 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 480 6 1 7 2.6 CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
67903275 186629 None 4 Human Functional pIC50 = 7.5 7.5 257 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4877651 186629 None 4 Human Functional pIC50 = 7.5 7.5 257 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
142534170 166900 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 591 9 1 7 5.8 CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4284403 166900 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 591 9 1 7 5.8 CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44292039 182199 None 1 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 547 8 1 8 5.5 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47817 182199 None 1 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 547 8 1 8 5.5 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956801 208568 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85765 208568 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 555 9 1 7 5.0 CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10251520 98875 None 0 Rabbit Functional pIC50 = 6.5 6.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 419 5 0 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 10.1021/jm00078a013
CHEMBL278656 98875 None 0 Rabbit Functional pIC50 = 6.5 6.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 419 5 0 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 10.1021/jm00078a013
5731496 53199 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 2 1 2 4.8 Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 nan
CHEMBL1598569 53199 None 6 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 2 1 2 4.8 Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 nan
1613606 48037 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 8 1 7 1.6 Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] nan
CHEMBL1550301 48037 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 392 8 1 7 1.6 Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] nan
44417426 141663 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 469 6 2 5 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 10.1021/jm0603163
CHEMBL384936 141663 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 469 6 2 5 5.1 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 10.1021/jm0603163
14956751 208759 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87073 208759 None 0 Rabbit Functional pIC50 = 7.5 7.5 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956802 208773 None 0 Rabbit Functional pIC50 = 7.5 7.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87184 208773 None 0 Rabbit Functional pIC50 = 7.5 7.5 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 9 1 7 5.5 CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
3941 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
3961 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
3961.0 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
590 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
CHEMBL191 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
DB00678 2347 None 64 Bovine Functional pIC50 = 6.5 6.5 -134 11
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80365-0
44355656 116148 None 0 Rabbit Functional pIC50 = 5.5 5.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 6 1 6 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 10.1021/jm00078a013
CHEMBL335680 116148 None 0 Rabbit Functional pIC50 = 5.5 5.5 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 6 1 6 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 10.1021/jm00078a013
44202070 39629 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 1 0 2 3.5 Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 nan
CHEMBL1474191 39629 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 271 1 0 2 3.5 Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 nan
1730709 24048 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 8 1 6 3.0 Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1338165 24048 None 9 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 8 1 6 3.0 Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
2899190 52567 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.6 Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] nan
CHEMBL1592181 52567 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 6 0 7 1.6 Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] nan
2285607 38572 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 9 1 7 3.1 COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 nan
CHEMBL1464749 38572 None 7 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 400 9 1 7 3.1 COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 nan
44201736 27470 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 586 9 2 5 5.2 O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 nan
CHEMBL1368499 27470 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 586 9 2 5 5.2 O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 nan
16195321 51057 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 6 0 5 4.9 CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 nan
CHEMBL1578651 51057 None 2 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 413 6 0 5 4.9 CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 nan
10344571 116678 None 0 Rabbit Functional pIC50 = 7.5 7.5 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 116678 None 0 Rabbit Functional pIC50 = 7.5 7.5 125 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
4210369 42444 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 424 8 1 6 4.0 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl nan
CHEMBL1499072 42444 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 424 8 1 6 4.0 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl nan
1726742 33403 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 9 1 7 2.9 CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
CHEMBL1419495 33403 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 9 1 7 2.9 CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
9548123 47778 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 nan
CHEMBL1548173 47778 None 0 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 nan
5416363 108239 None 2 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 1 3 3.5 C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 nan
CHEMBL3196324 108239 None 2 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 1 3 3.5 C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 nan
44292214 175994 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 9 2 9 4.6 CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45864 175994 None 0 Bovine Functional pIC50 = 7.5 7.5 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 577 9 2 9 4.6 CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10364891 26253 None 0 Rabbit Functional pIC50 = 6.5 6.5 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 26253 None 0 Rabbit Functional pIC50 = 6.5 6.5 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
9550553 54537 None 5 Human Functional pIC50 = 5.5 5.5 2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1610025 54537 None 5 Human Functional pIC50 = 5.5 5.5 2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 445 8 1 11 4.3 CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] nan
1266032 40891 None 3 Human Functional pIC50 = 5.5 5.5 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 2 0 3 4.9 O=C(Sc1cccc2cccnc12)c1ccccc1Br nan
CHEMBL1486214 40891 None 3 Human Functional pIC50 = 5.5 5.5 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 2 0 3 4.9 O=C(Sc1cccc2cccnc12)c1ccccc1Br nan
9608279 107846 None 4 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 366 6 1 8 3.1 COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 nan
CHEMBL3191846 107846 None 4 Human Functional pIC50 = 5.5 5.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 366 6 1 8 3.1 COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 nan
5341487 72375 None 14 Human Functional pIC50 = 5.5 5.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 3 3.0 C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 nan
CHEMBL1984876 72375 None 14 Human Functional pIC50 = 5.5 5.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 3 3.0 C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 nan
11100 126023 None 54 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 192 3 1 4 1.8 O=C(c1ccco1)C(O)c1ccco1 nan
CHEMBL364893 126023 None 54 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 192 3 1 4 1.8 O=C(c1ccco1)C(O)c1ccco1 nan
135472780 28454 None 5 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C nan
CHEMBL1375373 28454 None 5 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C nan
2360979 38961 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 275 5 1 3 3.6 COc1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
CHEMBL1467838 38961 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 275 5 1 3 3.6 COc1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
3106500 24797 None 7 Human Functional pIC50 = 4.5 4.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 3 1 7 1.5 CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 nan
CHEMBL1344603 24797 None 7 Human Functional pIC50 = 4.5 4.5 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 306 3 1 7 1.5 CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 nan
2431535 38934 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 0 4 4.1 O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl nan
CHEMBL1467556 38934 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 0 4 4.1 O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl nan
2324620 24907 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 4 4 4 4.3 CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O nan
CHEMBL1345564 24907 None 10 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 455 4 4 4 4.3 CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O nan
1875884 24512 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 436 5 3 6 3.0 COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 nan
CHEMBL1342221 24512 None 4 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 436 5 3 6 3.0 COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 nan
16012896 33007 None 8 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 494 7 1 7 3.0 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 nan
CHEMBL1416089 33007 None 8 Human Functional pIC50 = 5.5 5.5 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 494 7 1 7 3.0 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 nan
2352555 52388 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 nan
CHEMBL1589900 52388 None 3 Human Functional pIC50 = 4.5 4.5 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 nan
3146836 107714 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 4 1 6 5.6 CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 nan
CHEMBL3190347 107714 None 6 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 399 4 1 6 5.6 CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 nan
52936725 61270 None 22 Human Functional pIC50 = 5.4 5.4 -758 10
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 432 6 2 4 6.3 Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 10.6019/CHEMBL5442687
CHEMBL1766103 61270 None 22 Human Functional pIC50 = 5.4 5.4 -758 10
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 432 6 2 4 6.3 Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 10.6019/CHEMBL5442687
135400342 39778 None 4 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 4 2 7 2.2 O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 nan
CHEMBL1476264 39778 None 4 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 4 2 7 2.2 O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 nan
1612942 40849 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 7 1 6 2.4 Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 nan
CHEMBL1485784 40849 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 370 7 1 6 2.4 Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 nan
24818379 41111 None 3 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 6 2 8 1.3 COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] nan
CHEMBL1487991 41111 None 3 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 6 2 8 1.3 COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] nan
82533 41057 None 48 Human Functional pIC50 = 5.4 5.4 -6 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 41057 None 48 Human Functional pIC50 = 5.4 5.4 -6 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
5286934 49315 None 4 Human Functional pIC50 = 5.4 5.4 -2 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
CHEMBL1563483 49315 None 4 Human Functional pIC50 = 5.4 5.4 -2 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
930382 34018 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1424582 34018 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 nan
2811457 34430 None 2 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 2 4 3.2 Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 nan
CHEMBL1428121 34430 None 2 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 2 4 3.2 Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 nan
621 3035 None 27 Human Functional pIC50 = 5.4 5.4 -10471 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.6019/CHEMBL5442687
9937534 3035 None 27 Human Functional pIC50 = 5.4 5.4 -10471 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.6019/CHEMBL5442687
CHEMBL329650 3035 None 27 Human Functional pIC50 = 5.4 5.4 -10471 6
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.6019/CHEMBL5442687
14971679 111714 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 608 10 1 7 7.8 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL328598 111714 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 608 10 1 7 7.8 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
108185 1614 None 50 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
586 1614 None 50 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
CHEMBL907 1614 None 50 Rat Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00057a009
108185 1614 None 50 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
586 1614 None 50 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
CHEMBL907 1614 None 50 Rabbit Functional pIC50 = 7.4 7.4 -3 5
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
14956783 208234 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 414 8 1 8 2.8 CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL82920 208234 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 414 8 1 8 2.8 CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9612783 107980 None 2 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 345 6 1 4 3.7 C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 nan
CHEMBL3193378 107980 None 2 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 345 6 1 4 3.7 C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 nan
142534004 167454 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4294618 167454 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
15229102 101246 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295695 101246 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.9 CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
9982458 26517 None 0 Rabbit Functional pIC50 = 6.4 6.4 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 10.1021/jm00078a014
CHEMBL136034 26517 None 0 Rabbit Functional pIC50 = 6.4 6.4 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 10.1021/jm00078a014
1720698 19546 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 8 1 7 1.3 O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1299557 19546 None 8 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 8 1 7 1.3 O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
2812498 43657 None 2 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 5 2 4 4.3 Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 nan
CHEMBL1509694 43657 None 2 Human Functional pIC50 = 5.4 5.4 2 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 362 5 2 4 4.3 Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 nan
888488 50713 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 5 0 7 1.7 Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] nan
CHEMBL1575784 50713 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 5 0 7 1.7 Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] nan
2766929 50324 None 21 Human Functional pIC50 = 4.4 4.4 -20 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
CHEMBL1572001 50324 None 21 Human Functional pIC50 = 4.4 4.4 -20 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
130606 36280 None 44 Human Functional pIC50 = 5.4 5.4 -9 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 4 1 4 3.4 COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 nan
CHEMBL1445650 36280 None 44 Human Functional pIC50 = 5.4 5.4 -9 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 4 1 4 3.4 COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 nan
44292173 172555 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44798 172555 None 0 Bovine Functional pIC50 = 7.4 7.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
164616479 185422 None 0 Human Functional pIC50 = 6.4 6.4 16 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4859498 185422 None 0 Human Functional pIC50 = 6.4 6.4 16 2
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
2426323 37582 None 3 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.6 Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1456428 37582 None 3 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.6 Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
1472216 50628 None 10 Human Functional pIC50 = 5.4 5.4 -3 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 384 6 1 4 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 nan
CHEMBL1574879 50628 None 10 Human Functional pIC50 = 5.4 5.4 -3 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 384 6 1 4 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 nan
135421501 49844 None 9 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 344 2 1 3 3.8 COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
CHEMBL1567702 49844 None 9 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 344 2 1 3 3.8 COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
16193016 56145 None 4 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
CHEMBL1602056 56145 None 4 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
CHEMBL1625597 56145 None 4 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 354 4 0 2 3.4 O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 nan
3368605 19828 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 504 5 0 6 5.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O nan
CHEMBL1301939 19828 None 7 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 504 5 0 6 5.4 O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O nan
2114872 20790 None 3 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 2 1 4 3.1 O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 nan
CHEMBL1309573 20790 None 3 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 2 1 4 3.1 O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 nan
2928370 45481 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 5 1 5 3.2 CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 nan
CHEMBL1528033 45481 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 356 5 1 5 3.2 CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 nan
135426090 34355 None 9 Human Functional pIC50 = 5.4 5.4 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 318 3 2 6 4.0 Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 nan
CHEMBL1427431 34355 None 9 Human Functional pIC50 = 5.4 5.4 3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 318 3 2 6 4.0 Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 nan
135632169 51684 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
136087362 51684 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
CHEMBL1583998 51684 None 5 Human Functional pIC50 = 4.4 4.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 419 5 2 7 2.4 O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O nan
10456041 25863 None 0 Rabbit Functional pIC50 = 8.4 8.4 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 25863 None 0 Rabbit Functional pIC50 = 8.4 8.4 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
44459595 99511 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL2079785 99511 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
CHEMBL283055 99511 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 516 6 2 7 5.1 CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)80348-6
44459878 99761 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 574 8 1 9 4.6 COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O 10.1016/S0960-894X(01)80348-6
CHEMBL284704 99761 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsInhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings
ChEMBL 574 8 1 9 4.6 COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O 10.1016/S0960-894X(01)80348-6
53657506 70910 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 557 10 1 8 4.3 CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951138 70910 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 557 10 1 8 4.3 CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956738 208256 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83180 208256 None 0 Rabbit Functional pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9870652 70916 None 54 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
9870652.0 70916 None 54 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL1951143 70916 None 54 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
DB09279 70916 None 54 Human Functional pIC50 = 8.4 8.4 -15 2
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.08.036
11974939 82170 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 466 5 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 10.1021/jm0603163
CHEMBL216747 82170 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 466 5 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 10.1021/jm0603163
10183373 165105 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL422593 165105 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10183373 165105 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL422593 165105 None 0 Rabbit Functional pIC50 = 8.3 8.3 3 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 9 1 7 4.3 CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54199501 70891 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 486 10 1 8 3.9 CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951119 70891 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 486 10 1 8 3.9 CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
54558598 70900 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 499 10 1 7 3.8 CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951128 70900 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 499 10 1 7 3.8 CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
142534183 167365 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 503 8 1 7 4.0 CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4293170 167365 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 503 8 1 7 4.0 CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956794 208536 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85545 208536 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.9 CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
3941 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
3961 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
590 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.4 7.4 -19 11
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00075a014
5335625 108749 None 7 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 3 1 3 3.2 O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL3208035 108749 None 7 Human Functional pIC50 = 5.4 5.4 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 293 3 1 3 3.2 O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 nan
46495021 107884 None 4 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 5 1 7 1.7 O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 nan
CHEMBL3192235 107884 None 4 Human Functional pIC50 = 5.4 5.4 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 5 1 7 1.7 O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 nan
14971636 114877 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 6.0 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334083 114877 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 6.0 CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44292040 101189 None 0 Bovine Functional pIC50 = 6.4 6.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 601 9 1 9 6.9 CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295279 101189 None 0 Bovine Functional pIC50 = 6.4 6.4 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 601 9 1 9 6.9 CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
5759185 38688 None 3 Human Functional pIC50 = 5.4 5.4 -5 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
CHEMBL1465592 38688 None 3 Human Functional pIC50 = 5.4 5.4 -5 5
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
44634573 2748 None 1 Human Functional pIC50 = 5.4 5.4 -489 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.6019/CHEMBL5442687
9168 2748 None 1 Human Functional pIC50 = 5.4 5.4 -489 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.6019/CHEMBL5442687
CHEMBL1474387 2748 None 1 Human Functional pIC50 = 5.4 5.4 -489 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.6019/CHEMBL5442687
CHEMBL1622930 2748 None 1 Human Functional pIC50 = 5.4 5.4 -489 15
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.6019/CHEMBL5442687
5217512 42414 None 2 Human Functional pIC50 = 5.4 5.4 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 278 3 3 5 2.8 NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 nan
CHEMBL1498886 42414 None 2 Human Functional pIC50 = 5.4 5.4 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 278 3 3 5 2.8 NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 nan
10371403 66943 None 18 Rabbit Functional pIC50 = 5.4 5.4 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL186572 66943 None 18 Rabbit Functional pIC50 = 5.4 5.4 - 1
Vasorelaxing potency in the presence of eserin was determinedVasorelaxing potency in the presence of eserin was determined
ChEMBL 601 13 1 10 5.8 CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
14956743 164200 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL420970 164200 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
56991879 70893 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 528 13 1 8 4.9 CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951121 70893 None 0 Rabbit Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 528 13 1 8 4.9 CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
1692 2154 None 25 Human Functional pIC50 = 5.4 5.4 -144 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
5311340 2154 None 25 Human Functional pIC50 = 5.4 5.4 -144 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
CHEMBL140979 2154 None 25 Human Functional pIC50 = 5.4 5.4 -144 18
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 411 6 2 4 5.5 CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C 10.6019/CHEMBL5442687
9618012 77947 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 3 1 3 3.4 C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 nan
CHEMBL2094484 77947 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 3 1 3 3.4 C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 nan
1475345 29244 None 9 Human Functional pIC50 = 5.3 5.3 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 nan
CHEMBL1382438 29244 None 9 Human Functional pIC50 = 5.3 5.3 -1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 1 4 4.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 nan
18666499 175723 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 9 2 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45805 175723 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 9 2 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
11743704 115562 None 0 Rabbit Functional pIC50 = 5.3 5.3 3 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 115562 None 0 Rabbit Functional pIC50 = 5.3 5.3 3 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
44292038 182641 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47873 182641 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.0 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
5218417 24822 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 285 3 0 2 3.9 CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 nan
CHEMBL1344824 24822 None 4 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 285 3 0 2 3.9 CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 nan
10411653 24432 None 0 Rabbit Functional pIC50 = 7.3 7.3 208 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 24432 None 0 Rabbit Functional pIC50 = 7.3 7.3 208 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
9893924 4750 None 24 Human Functional pIC50 = 5.3 5.3 -169 9
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 554 11 3 4 5.4 S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 10.6019/CHEMBL5442687
CHEMBL103769 4750 None 24 Human Functional pIC50 = 5.3 5.3 -169 9
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 554 11 3 4 5.4 S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 10.6019/CHEMBL5442687
14956799 106955 None 0 Rabbit Functional pIC50 = 6.3 6.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314590 106955 None 0 Rabbit Functional pIC50 = 6.3 6.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
6873617 72441 None 5 Human Functional pIC50 = 5.3 5.3 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 4 1 4 4.7 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 nan
CHEMBL1987579 72441 None 5 Human Functional pIC50 = 5.3 5.3 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 386 4 1 4 4.7 O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 nan
10367704 22350 None 0 Rabbit Functional pIC50 = 8.3 8.3 25 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 22350 None 0 Rabbit Functional pIC50 = 8.3 8.3 25 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
131654 208861 None 10 Rabbit Functional pIC50 = 8.3 8.3 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 208861 None 10 Rabbit Functional pIC50 = 8.3 8.3 1 2
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956748 208431 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL84627 208431 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9887844 163295 None 4 Guinea pig Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm9504722
CHEMBL418226 163295 None 4 Guinea pig Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneIn vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1021/jm9504722
54393565 70911 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 541 10 1 8 3.6 CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951139 70911 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 541 10 1 8 3.6 CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
10004112 25538 None 0 Rabbit Functional pIC50 = 8.3 8.3 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 25538 None 0 Rabbit Functional pIC50 = 8.3 8.3 93 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 116671 None 0 Rabbit Functional pIC50 = 8.3 8.3 107 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 116671 None 0 Rabbit Functional pIC50 = 8.3 8.3 107 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
2583 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
592 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
65999 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
65999.0 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
CHEMBL1017 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
DB00966 3776 None 69 Human Functional pIC50 = 8.3 8.3 -1 16
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.6019/CHEMBL5442687
142534191 166879 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 9 1 8 4.2 CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4284022 166879 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 559 9 1 8 4.2 CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956758 106587 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314042 106587 None 0 Rabbit Functional pIC50 = 8.3 8.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 9 1 9 4.1 CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956769 107172 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL316052 107172 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 9 1 7 5.3 CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956762 98884 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL278741 98884 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.6 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
54479908 70913 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 10 1 7 4.3 CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951140 70913 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 525 10 1 7 4.3 CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956759 208560 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85704 208560 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956800 208608 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86143 208608 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3941 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
590 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00069a015
14956805 208802 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 10 1 8 5.0 CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87354 208802 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 515 10 1 8 5.0 CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9893748 182630 None 0 Bovine Functional pIC50 = 6.3 6.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 549 9 2 9 4.5 CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47872 182630 None 0 Bovine Functional pIC50 = 6.3 6.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 549 9 2 9 4.5 CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
742856 53785 None 12 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 4 1 2 4.3 O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 nan
CHEMBL1603871 53785 None 12 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 4 1 2 4.3 O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 nan
14956789 208897 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 489 10 1 9 3.7 CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL88002 208897 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 489 10 1 9 3.7 CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
2811329 28660 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 3 2 4 3.0 Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl nan
CHEMBL1377329 28660 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 279 3 2 4 3.0 Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl nan
4328866 19500 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 247 3 0 4 1.2 CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 nan
CHEMBL1299266 19500 None 2 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 247 3 0 4 1.2 CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 nan
5770964 26463 None 0 Human Functional pIC50 = 5.3 5.3 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 9 2 6 2.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 nan
CHEMBL1359902 26463 None 0 Human Functional pIC50 = 5.3 5.3 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 444 9 2 6 2.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 nan
2744279 26667 None 0 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 0 10 2.5 CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C nan
CHEMBL1361740 26667 None 0 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 0 10 2.5 CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C nan
4068403 20729 None 9 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 4 1 6 4.0 O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] nan
CHEMBL1309127 20729 None 9 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 4 1 6 4.0 O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] nan
1610 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
1610 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
3941 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
3941 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
3961 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
3961 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
590 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
590 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a013
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.3 7.3 -19 11
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00078a014
788411 27378 None 8 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 nan
CHEMBL1367827 27378 None 8 Human Functional pIC50 = 5.3 5.3 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 nan
14971674 209758 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93289 209758 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
15233933 101219 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295532 101219 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14971693 112974 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.5 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL331063 112974 None 0 Rabbit Functional pIC50 = 7.3 7.3 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 560 9 1 7 6.5 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
18655851 101355 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 623 9 1 8 6.7 CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296519 101355 None 0 Bovine Functional pIC50 = 7.3 7.3 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 623 9 1 8 6.7 CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
100520 32733 None 2 Human Functional pIC50 = 5.3 5.3 -4 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 32733 None 2 Human Functional pIC50 = 5.3 5.3 -4 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
788410 21174 None 10 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(NCC(=O)c2ccccc2)cc1Cl nan
CHEMBL1312651 21174 None 10 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(NCC(=O)c2ccccc2)cc1Cl nan
44292072 101354 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 618 9 1 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296518 101354 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 618 9 1 9 4.7 CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956773 208553 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 504 9 2 6 5.0 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00069a015
CHEMBL85659 208553 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 504 9 2 6 5.0 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 10.1021/jm00069a015
44292162 172394 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44749 172394 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
16446380 31630 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 447 7 1 7 3.4 COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 nan
CHEMBL1404578 31630 None 8 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 447 7 1 7 3.4 COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 nan
718402 33896 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.6 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 nan
CHEMBL1423567 33896 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 5 0 6 2.6 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 nan
16437205 32011 None 8 Human Functional pIC50 = 5.2 5.2 -5 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.7 CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
CHEMBL1407961 32011 None 8 Human Functional pIC50 = 5.2 5.2 -5 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.7 CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 nan
6873485 107634 None 7 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 5 4.9 CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 nan
CHEMBL3189289 107634 None 7 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 410 7 1 5 4.9 CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 nan
9569064 72274 None 1 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 6 1 4 4.0 C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 nan
CHEMBL1981898 72274 None 1 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 6 1 4 4.0 C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 nan
1481 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
3749 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
3749.0 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
589 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
6908 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
CHEMBL1513 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
DB01029 2066 None 66 Human Functional pIC50 = 8.2 8.2 -2 6
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
108185 1614 None 50 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
586 1614 None 50 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
CHEMBL907 1614 None 50 Rabbit Functional pIC50 = 8.2 8.2 -3 5
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00069a015
57393229 70918 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 7 5.5 CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951145 70918 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 7 5.5 CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14956740 208266 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83248 208266 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971677 111574 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327837 111574 None 0 Rabbit Functional pIC50 = 8.2 8.2 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956775 206439 None 0 Rabbit Functional pIC50 = 7.2 7.2 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL69508 206439 None 0 Rabbit Functional pIC50 = 7.2 7.2 -1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 375 7 2 7 3.2 CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956808 208889 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 580 13 1 9 4.9 CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87957 208889 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 580 13 1 9 4.9 CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
330973 49703 None 0 Human Functional pIC50 = 5.2 5.2 -16 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49703 None 0 Human Functional pIC50 = 5.2 5.2 -16 4
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
2812572 25032 None 2 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 274 4 2 2 3.7 CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 nan
CHEMBL1346661 25032 None 2 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 274 4 2 2 3.7 CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 nan
890649 53646 None 12 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 3 0 6 3.6 O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 nan
CHEMBL1602759 53646 None 12 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 3 0 6 3.6 O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 nan
44292456 101216 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 658 9 1 9 5.6 CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295514 101216 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 658 9 1 9 5.6 CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
1610 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
3941 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
3961 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
3961.0 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
590 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
CHEMBL191 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
DB00678 2347 None 64 Rabbit Functional pIC50 = 7.2 7.2 -19 11
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2011.12.116
16436607 24073 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 nan
CHEMBL1338304 24073 None 9 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 486 6 1 7 2.6 CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 nan
9619214 108133 None 4 Human Functional pIC50 = 5.2 5.2 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 1 8 2.9 Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 nan
CHEMBL3195226 108133 None 4 Human Functional pIC50 = 5.2 5.2 -2 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 351 5 1 8 2.9 Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 nan
11744592 115567 None 0 Rabbit Functional pIC50 = 6.2 6.2 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 115567 None 0 Rabbit Functional pIC50 = 6.2 6.2 33 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
6091989 49866 None 5 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 337 5 1 5 4.1 COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC nan
CHEMBL1567899 49866 None 5 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 337 5 1 5 4.1 COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC nan
42611190 3156 None 14 Human Functional pIC50 = 5.2 5.2 -1621 21
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442687
5802 3156 None 14 Human Functional pIC50 = 5.2 5.2 -1621 21
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442687
CHEMBL1800685 3156 None 14 Human Functional pIC50 = 5.2 5.2 -1621 21
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
ChEMBL 475 4 2 2 7.4 OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F 10.6019/CHEMBL5442687
44292070 171957 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44690 171957 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44292342 177364 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL46361 177364 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 8 1 8 6.3 CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
6883924 71715 None 4 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 1 4 3.7 O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl nan
CHEMBL1964873 71715 None 4 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 315 3 1 4 3.7 O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl nan
10366811 24834 None 0 Rabbit Functional pIC50 = 7.2 7.2 31 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 24834 None 0 Rabbit Functional pIC50 = 7.2 7.2 31 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
3117 210300 None 60 Human Functional pIC50 = 5.2 5.2 -9 24
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
CHEMBL964 210300 None 60 Human Functional pIC50 = 5.2 5.2 -9 24
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 296 4 0 4 3.6 CCN(CC)C(=S)SSC(=S)N(CC)CC nan
780062 28955 None 4 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 276 3 2 4 3.4 Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 nan
CHEMBL1380035 28955 None 4 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 276 3 2 4 3.4 Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 nan
10048602 26058 None 0 Rabbit Functional pIC50 = 6.2 6.2 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 26058 None 0 Rabbit Functional pIC50 = 6.2 6.2 37 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9556585 155002 None 6 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 3 1 3 2.6 O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 nan
CHEMBL400912 155002 None 6 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 3 1 3 2.6 O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 nan
14956800 208608 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86143 208608 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956810 208617 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 10 1 8 5.9 CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86232 208617 None 0 Rabbit Functional pIC50 = 6.2 6.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 10 1 8 5.9 CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
135449568 41676 None 3 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 4 2 7 2.5 COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 nan
CHEMBL1492017 41676 None 3 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 4 2 7 2.5 COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 nan
44292428 101148 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 644 9 1 9 5.3 CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL294992 101148 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 644 9 1 9 5.3 CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44291956 171377 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 619 10 1 10 5.3 CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL44605 171377 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 619 10 1 10 5.3 CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956746 208652 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86440 208652 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
379338 16896 None 22 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 2 0 4 3.4 COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
CHEMBL125044 16896 None 22 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 2 0 4 3.4 COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 nan
14956807 106180 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 12 1 9 4.9 CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313435 106180 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 566 12 1 9 4.9 CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956755 106205 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313579 106205 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 469 8 1 7 4.4 CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10202093 208893 None 0 Rabbit Functional pIC50 = 8.1 8.1 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87985 208893 None 0 Rabbit Functional pIC50 = 8.1 8.1 2 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 8 1 7 3.9 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
145987183 167328 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 597 9 1 7 6.1 CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4292297 167328 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 597 9 1 7 6.1 CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44291955 96679 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL263471 96679 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 589 8 1 8 6.4 CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
18942289 101385 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 595 9 1 8 6.8 CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL296719 101385 None 0 Bovine Functional pIC50 = 7.2 7.2 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 595 9 1 8 6.8 CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
10003482 165838 None 0 Rabbit Functional pIC50 = 7.2 7.2 158 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 165838 None 0 Rabbit Functional pIC50 = 7.2 7.2 158 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
14956776 106024 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313017 106024 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956790 171453 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 475 10 2 8 3.6 CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL446152 171453 None 0 Rabbit Functional pIC50 = 7.2 7.2 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 475 10 2 8 3.6 CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
851388 55242 None 7 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
CHEMBL1328306 55242 None 7 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
CHEMBL1617841 55242 None 7 Human Functional pIC50 = 5.2 5.2 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 229 4 1 2 3.1 O=C(CNc1ccc(F)cc1)c1ccccc1 nan
1728272 44849 None 7 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 5 3 4 1.5 CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 nan
CHEMBL1522211 44849 None 7 Human Functional pIC50 = 5.2 5.2 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 5 3 4 1.5 CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 nan
135411933 41230 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 1 1 2 3.5 O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 nan
CHEMBL1488802 41230 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 300 1 1 2 3.5 O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 nan
2796987 23381 None 2 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 2 3 2.7 NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
CHEMBL1332717 23381 None 2 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 2 3 2.7 NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 nan
379337 164302 None 22 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 258 1 0 3 3.4 O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 nan
CHEMBL421088 164302 None 22 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 258 1 0 3 3.4 O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 nan
788612 52342 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 nan
CHEMBL1589540 52342 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 nan
583493 42748 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 255 5 2 3 2.7 O=C(CNc1ccccc1C(=O)O)c1ccccc1 nan
CHEMBL1501792 42748 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 255 5 2 3 2.7 O=C(CNc1ccccc1C(=O)O)c1ccccc1 nan
1593681 30373 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 423 9 2 8 1.1 O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1391919 30373 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 423 9 2 8 1.1 O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
10258828 14665 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 498 9 1 7 5.0 CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120549 14665 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 498 9 1 7 5.0 CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971696 113491 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 572 9 1 7 6.7 CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
CHEMBL331886 113491 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 572 9 1 7 6.7 CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl 10.1021/jm00075a014
14956782 208863 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 457 8 1 7 3.8 CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87780 208863 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 457 8 1 7 3.8 CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44341650 169990 None 0 Human Functional pIC50 = 5.1 5.1 -2 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL444060 169990 None 0 Human Functional pIC50 = 5.1 5.1 -2 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
135400371 53316 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 1 1 2 3.8 Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 nan
CHEMBL1599499 53316 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 1 1 2 3.8 Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 nan
135403068 23511 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 358 3 1 3 4.2 CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
CHEMBL1333730 23511 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 358 3 1 3 4.2 CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 nan
6884203 108300 None 6 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 352 4 1 4 4.1 O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 nan
CHEMBL3197021 108300 None 6 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 352 4 1 4 4.1 O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 nan
2989697 48762 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 5 1 6 2.4 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 nan
CHEMBL1558462 48762 None 14 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 5 1 6 2.4 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 nan
10435200 23871 None 0 Rabbit Functional pIC50 = 6.1 6.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 5 1 7 4.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 10.1021/jm00078a013
CHEMBL133654 23871 None 0 Rabbit Functional pIC50 = 6.1 6.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 5 1 7 4.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 10.1021/jm00078a013
5953874 41115 None 3 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 6 2.8 N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 nan
CHEMBL1488024 41115 None 3 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 6 2.8 N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 nan
9675542 107865 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.8 Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 nan
CHEMBL3191999 107865 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.8 Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 nan
44292215 175544 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 605 9 1 10 4.8 CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL45766 175544 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 605 9 1 10 4.8 CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
14956774 208696 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86741 208696 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 452 8 1 8 3.7 CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
6873171 108780 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 283 2 1 3 1.9 S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 nan
CHEMBL3208447 108780 None 4 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 283 2 1 3 1.9 S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 nan
14971678 14551 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120290 14551 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10365283 25861 None 0 Rabbit Functional pIC50 = 8.1 8.1 416 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 25861 None 0 Rabbit Functional pIC50 = 8.1 8.1 416 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10223724 208215 None 0 Rabbit Functional pIC50 = 8.1 8.1 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL82797 208215 None 0 Rabbit Functional pIC50 = 8.1 8.1 1 2
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 417 9 1 7 3.7 CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10479472 115289 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 462 6 1 7 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL334660 115289 None 0 Rabbit Functional pIC50 = 8.1 8.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 462 6 1 7 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10344235 208618 None 0 Rabbit Functional pIC50 = 8.1 8.1 -1 3
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm0603163
CHEMBL86247 208618 None 0 Rabbit Functional pIC50 = 8.1 8.1 -1 3
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 460 5 1 7 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 10.1021/jm0603163
10322504 26391 None 0 Rabbit Functional pIC50 = 7.1 7.1 19 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 26391 None 0 Rabbit Functional pIC50 = 7.1 7.1 19 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
14956747 208432 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL84630 208432 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971673 112423 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.8 CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329466 112423 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 10 1 7 5.8 CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
5339648 72977 None 10 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 4 1 5 1.8 O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL2005961 72977 None 10 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 270 4 1 5 1.8 O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
10322995 115327 None 0 Rabbit Functional pIC50 = 7.1 7.1 134 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 115327 None 0 Rabbit Functional pIC50 = 7.1 7.1 134 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10026268 116994 None 0 Rabbit Functional pIC50 = 7.1 7.1 173 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 116994 None 0 Rabbit Functional pIC50 = 7.1 7.1 173 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
854200 36042 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 239 4 1 2 3.6 Cc1ccc(C(=O)CNc2ccccc2C)cc1 nan
CHEMBL1443417 36042 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 239 4 1 2 3.6 Cc1ccc(C(=O)CNc2ccccc2C)cc1 nan
973504 95275 None 6 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 1 5 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 nan
CHEMBL256042 95275 None 6 Human Functional pIC50 = 5.1 5.1 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 343 4 1 5 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 nan
44292180 181054 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL47583 181054 None 0 Bovine Functional pIC50 = 7.1 7.1 - 1
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 575 9 1 8 6.0 CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
200953 45853 None 3 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 196 1 0 2 2.5 O=C(C#Cc1ccccc1)c1ccco1 nan
CHEMBL1531308 45853 None 3 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 196 1 0 2 2.5 O=C(C#Cc1ccccc1)c1ccco1 nan
2812483 43598 None 2 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 245 3 2 4 2.4 Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 nan
CHEMBL1509162 43598 None 2 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 245 3 2 4 2.4 Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 nan
6873172 109138 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 263 2 1 3 1.5 Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
CHEMBL3213140 109138 None 9 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 263 2 1 3 1.5 Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
10437543 26275 None 0 Rabbit Functional pIC50 = 6.1 6.1 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 26275 None 0 Rabbit Functional pIC50 = 6.1 6.1 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
878879 38195 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccccc1NCC(=O)c1ccc(Br)cc1 nan
CHEMBL1461745 38195 None 6 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 4 1 2 4.1 Cc1ccccc1NCC(=O)c1ccc(Br)cc1 nan
44341785 10149 None 0 Human Functional pIC50 = 5.1 5.1 -3 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL115771 10149 None 0 Human Functional pIC50 = 5.1 5.1 -3 3
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
6792924 108044 None 6 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 3 1 3 2.5 O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 nan
CHEMBL3194040 108044 None 6 Human Functional pIC50 = 5.1 5.1 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 3 1 3 2.5 O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 nan
1511959 21132 None 7 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 359 3 0 8 2.0 CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 nan
CHEMBL1312377 21132 None 7 Human Functional pIC50 = 5.1 5.1 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 359 3 0 8 2.0 CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 nan
10050755 115575 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 10.1021/jm00078a014
CHEMBL335276 115575 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 478 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 10.1021/jm00078a014
54508770 70897 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 10 2 7 3.8 CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951125 70897 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 472 10 2 7 3.8 CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971682 111550 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 551 11 1 9 5.7 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL327718 111550 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 551 11 1 9 5.7 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956771 208811 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87392 208811 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 482 8 1 9 3.8 CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
57393228 70914 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 539 10 1 7 4.7 CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951141 70914 None 0 Rabbit Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 539 10 1 7 4.7 CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971676 163469 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL419321 163469 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956776 106024 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313017 106024 None 0 Rabbit Functional pIC50 = 7.1 7.1 - 1
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 389 7 1 7 2.8 CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
824082 26489 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 5 0 5 2.6 Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 nan
CHEMBL1360149 26489 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 326 5 0 5 2.6 Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 nan
2564786 44714 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 225 4 1 2 3.3 Cc1ccc(C(=O)CNc2ccccc2)cc1 nan
CHEMBL1521054 44714 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 225 4 1 2 3.3 Cc1ccc(C(=O)CNc2ccccc2)cc1 nan
11754335 25311 None 0 Rabbit Functional pIC50 = 7.0 7.0 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 25311 None 0 Rabbit Functional pIC50 = 7.0 7.0 186 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1625575 54301 None 6 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 297 5 1 5 1.5 CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 nan
CHEMBL1608078 54301 None 6 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 297 5 1 5 1.5 CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 nan
5680364 54920 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 2 1 4 0.9 CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 nan
CHEMBL1613515 54920 None 4 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 272 2 1 4 0.9 CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 nan
2411934 55466 None 0 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
CHEMBL1409219 55466 None 0 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
CHEMBL1619798 55466 None 0 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 451 10 2 6 4.3 CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C nan
2170433 46205 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 2.3 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1534477 46205 None 7 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 2.3 O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
9590742 107629 None 1 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 nan
CHEMBL3189245 107629 None 1 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 3 1 3 2.9 C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 nan
10434876 116682 None 0 Rabbit Functional pIC50 = 7.0 7.0 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 116682 None 0 Rabbit Functional pIC50 = 7.0 7.0 7 2
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
2474590 43180 None 3 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 2 1 4 3.2 O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 nan
CHEMBL1505604 43180 None 3 Human Functional pIC50 = 5.0 5.0 -1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 2 1 4 3.2 O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 nan
9667523 108906 None 7 Human Functional pIC50 = 5.0 5.0 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 6 1 6 2.3 C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 nan
CHEMBL3210072 108906 None 7 Human Functional pIC50 = 5.0 5.0 -3 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 328 6 1 6 2.3 C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 nan
14956770 208715 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 480 7 1 9 3.7 O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86853 208715 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 480 7 1 9 3.7 O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956785 208850 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 460 9 2 8 2.6 CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87682 208850 None 0 Rabbit Functional pIC50 = 7.0 7.0 - 1
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 460 9 2 8 2.6 CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1487013 51979 None 13 Human Functional pIC50 = 5.0 5.0 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 6 1.4 CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1586425 51979 None 13 Human Functional pIC50 = 5.0 5.0 1 3
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 317 3 1 6 1.4 CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
5337284 45720 None 3 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 nan
CHEMBL1530173 45720 None 3 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 nan
991372 53866 None 32 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 1 2 5 4.5 CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O nan
CHEMBL1604546 53866 None 32 Human Functional pIC50 = 5.0 5.0 1 2
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 1 2 5 4.5 CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O nan
135472791 22342 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 nan
CHEMBL1324011 22342 None 5 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 2 1 4 5.0 Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 nan
788618 20011 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 4 1 2 3.9 Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 nan
CHEMBL1303334 20011 None 8 Human Functional pIC50 = 5.0 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 4 1 2 3.9 Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 nan
788408 43559 None 8 Human Functional pIC50 = 5 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 nan
CHEMBL1508797 43559 None 8 Human Functional pIC50 = 5 5.0 - 1
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 259 4 1 2 3.9 Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 nan
6918269 98523 None 10 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL275875 98523 None 10 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL295959 98523 None 10 Human Functional pKd = 10.9 10.9 5 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
11527144 179211 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL297425 179211 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL47177 179211 None 0 Human Functional pKd = 10.9 10.9 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 561 8 1 8 5.6 CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
133031 100913 None 21 Rabbit Functional pKd = 10.3 10.3 -1 3
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL293511 100913 None 21 Rabbit Functional pKd = 10.3 10.3 -1 3
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
9887844 163295 None 4 Rabbit Functional pKd = 10.3 10.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL418226 163295 None 4 Rabbit Functional pKd = 10.3 10.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 411 6 1 5 4.9 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 10.1016/j.bmc.2010.10.043
9911332 44715 None 1 Rabbit Functional pKd = 10.2 10.2 - 0
Antagonism against Angiotensin II receptor, type 1 in rabbit aortaAntagonism against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 444 7 2 6 4.7 CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9604383
CHEMBL152106 44715 None 1 Rabbit Functional pKd = 10.2 10.2 - 0
Antagonism against Angiotensin II receptor, type 1 in rabbit aortaAntagonism against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 444 7 2 6 4.7 CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9604383
132387 162428 None 20 Rabbit Functional pKd = 10.1 10.1 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL416477 162428 None 20 Rabbit Functional pKd = 10.1 10.1 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 414 8 2 6 4.0 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O 10.1016/j.bmc.2010.10.043
108185 1614 None 50 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
586 1614 None 50 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
CHEMBL907 1614 None 50 Rabbit Functional pKd = 10.1 10.1 -3 5
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1016/j.bmc.2010.10.043
9802561 161345 None 27 Rabbit Functional pKd = 10.0 10.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 426 6 1 6 4.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 10.1016/j.bmc.2010.10.043
CHEMBL41194 161345 None 27 Rabbit Functional pKd = 10.0 10.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 426 6 1 6 4.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 10.1016/j.bmc.2010.10.043
19890807 111597 None 0 Rabbit Functional pKd = 10 10.0 - 0
Antagonistic ability of angiotensin II to contract rabbit aortaAntagonistic ability of angiotensin II to contract rabbit aorta
ChEMBL 466 8 1 7 5.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 10.1021/jm00070a012
CHEMBL327932 111597 None 0 Rabbit Functional pKd = 10 10.0 - 0
Antagonistic ability of angiotensin II to contract rabbit aortaAntagonistic ability of angiotensin II to contract rabbit aorta
ChEMBL 466 8 1 7 5.4 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 10.1021/jm00070a012
15657904 187588 None 2 Rabbit Functional pKd = 9.9 9.9 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL49410 187588 None 2 Rabbit Functional pKd = 9.9 9.9 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 415 8 2 7 3.4 CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O 10.1016/j.bmc.2010.10.043
19017678 176257 None 0 Human Functional pKd = 9.3 9.3 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 474 11 2 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL45927 176257 None 0 Human Functional pKd = 9.3 9.3 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 474 11 2 8 4.3 CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O 10.1016/j.bmc.2010.10.043
9935096 210230 None 1 Human Functional pKd = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9599 210230 None 1 Human Functional pKd = 9.3 9.3 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 485 8 1 7 5.3 CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
44373246 168370 None 0 Rabbit Functional pKd = 9.2 9.2 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
CHEMBL433895 168370 None 0 Rabbit Functional pKd = 9.2 9.2 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1016/j.bmc.2010.10.043
CHEMBL2373017 212813 None 0 Rat Functional pKd = 9.1 9.1 - 0
pA2 value for Angiotensin II receptorpA2 value for Angiotensin II receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCSSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/jm00169a019
9912059 185462 None 0 Rabbit Functional pKd = 9 9.0 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48602 185462 None 0 Rabbit Functional pKd = 9 9.0 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 459 7 1 6 4.5 CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
131654 208861 None 10 Rabbit Functional pKd = 8.9 8.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL87778 208861 None 10 Rabbit Functional pKd = 8.9 8.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
9801006 119793 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1016/j.bmc.2010.10.043
CHEMBL347610 119793 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 398 6 1 7 3.6 CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 10.1016/j.bmc.2010.10.043
178553 120308 None 15 Rabbit Functional pKd = 8.8 8.8 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 387 6 1 6 4.1 COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1016/j.bmc.2010.10.043
CHEMBL352257 120308 None 15 Rabbit Functional pKd = 8.8 8.8 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 387 6 1 6 4.1 COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C 10.1016/j.bmc.2010.10.043
70682146 76358 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058860 76358 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 569 10 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
46910493 76362 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058864 76362 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 615 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
9931685 208542 None 0 Human Functional pKd = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
CHEMBL85595 208542 None 0 Human Functional pKd = 8.7 8.7 1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 10.1016/j.bmc.2010.10.043
131857 206717 None 17 Rabbit Functional pKd = 8.7 8.7 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 383 5 1 4 5.0 Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL71162 206717 None 17 Rabbit Functional pKd = 8.7 8.7 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 383 5 1 4 5.0 Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
44438885 90988 None 0 Rabbit Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL239378 90988 None 0 Rabbit Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 417 8 2 5 4.6 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
2541 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
2541.0 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
587 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
6907 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
CHEMBL1016 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
DB00796 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
DB13919 786 None 65 Rat Functional pKd = 8 8.0 - 10
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.ejmech.2007.11.008
10094851 21304 None 0 Rat Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL131365 21304 None 0 Rat Functional pKd = 8 8.0 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 441 8 2 4 5.8 CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
1610 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
3941 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
3961 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
3961.0 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
590 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
CHEMBL191 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
DB00678 2347 None 64 Rat Functional pKd = 8 8.0 -9 11
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2008.10.056
24827770 95933 None 0 Rabbit Functional pKd = 8.0 8.0 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259114 95933 None 0 Rabbit Functional pKd = 8.0 8.0 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44438869 146423 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
CHEMBL392118 146423 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 413 5 1 8 3.2 COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 10.1016/j.bmcl.2007.02.042
44438900 147936 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL393305 147936 None 0 Rabbit Functional pKd = 7 7.0 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 403 7 2 5 4.2 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
44570265 178514 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 12 2 5 5.9 CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL465929 178514 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 12 2 5 5.9 CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
19351553 118762 None 0 Rabbit Functional pKd = 7 7.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 389 10 4 6 3.1 CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
CHEMBL341716 118762 None 0 Rabbit Functional pKd = 7 7.0 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 389 10 4 6 3.1 CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 10.1016/j.bmc.2010.10.043
CHEMBL264230 213068 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
CHEMBL384349 214783 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
1610 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3941 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3961 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
3961.0 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
590 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
CHEMBL191 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
DB00678 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmcl.2007.02.042
44438865 93428 None 0 Rabbit Functional pKd = 7.9 7.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245644 93428 None 0 Rabbit Functional pKd = 7.9 7.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 7 1 8 3.8 CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
1610 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3941 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3961 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
3961.0 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
590 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
CHEMBL191 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
DB00678 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2012.05.056
44570305 190427 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 545 10 2 5 6.4 CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL517626 190427 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 545 10 2 5 6.4 CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
1610 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3941 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3961 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
3961.0 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
590 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
CHEMBL191 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
DB00678 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2012.01.009
44348352 16535 None 0 Rabbit Functional pKd = 7.9 7.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
CHEMBL123713 16535 None 0 Rabbit Functional pKd = 7.9 7.9 1 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
1610 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3941 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961.0 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
590 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
CHEMBL191 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
DB00678 2347 None 64 Rabbit Functional pKd = 7.9 7.9 -19 11
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
44570215 183657 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 477 9 2 5 4.7 CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL480018 183657 None 0 Rat Functional pKd = 6.9 6.9 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 477 9 2 5 4.7 CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9906367 52165 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 349 4 1 5 3.1 C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 10.1016/j.bmc.2010.10.043
CHEMBL158794 52165 None 0 Human Functional pKd = 6.9 6.9 - 0
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 349 4 1 5 3.1 C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 10.1016/j.bmc.2010.10.043
44438902 169499 None 0 Rabbit Functional pKd = 5.9 5.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL442251 169499 None 0 Rabbit Functional pKd = 5.9 5.9 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 375 5 2 5 3.6 Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
46910495 76359 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058861 76359 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 585 11 2 7 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
24828707 95990 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
CHEMBL259353 95990 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 425 7 1 7 3.9 CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm7011563
44438870 92039 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241685 92039 None 0 Rabbit Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 469 9 1 8 4.6 CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
10250336 18893 None 0 Rat Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL128318 18893 None 0 Rat Functional pKd = 7.8 7.8 - 1
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 399 7 2 4 5.4 CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
53323218 60272 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668010 60272 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1741079 60272 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
Antagonist activity at angiotensin AT1 receptor in guinea pig ileumAntagonist activity at angiotensin AT1 receptor in guinea pig ileum
ChEMBL 417 7 2 5 4.5 CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
25110812 179145 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 455 9 2 4 6.1 CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL471334 179145 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 455 9 2 4 6.1 CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
1610 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3941 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3961 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
3961.0 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
590 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
CHEMBL191 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
DB00678 2347 None 64 Rabbit Functional pKd = 6.7 6.7 -19 11
Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 minsAntagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm7011563
44570214 183656 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 463 8 2 5 4.4 CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL480017 183656 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 463 8 2 5 4.4 CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9932483 210302 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
CHEMBL9642 210302 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 431 10 1 7 4.1 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 10.1016/j.bmc.2010.10.043
9954408 210426 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL9714 210426 None 0 Human Functional pKd = 8.7 8.7 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 430 10 1 6 4.7 CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
25112615 185997 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 503 9 2 4 7.0 CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL486847 185997 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 503 9 2 4 7.0 CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
44570306 178402 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 464 8 2 5 5.0 CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL465097 178402 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 464 8 2 5 5.0 CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
15224471 154923 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL400424 154923 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 441 8 2 7 4.1 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
2541 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
2541.0 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
587 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
6907 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
CHEMBL1016 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
DB00796 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
DB13919 786 None 65 Rat Functional pKd = 8.5 8.5 - 10
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1016/j.bmc.2008.10.056
4110026 207393 None 1 Rat Functional pKd = 8.5 8.5 - 2
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL7632 207393 None 1 Rat Functional pKd = 8.5 8.5 - 2
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 384 7 1 3 5.8 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
57380647 70378 None 0 Rabbit Functional pKd = 8.5 8.5 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 70378 None 0 Rabbit Functional pKd = 8.5 8.5 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
9823146 19368 None 0 Human Functional pKd = 8.5 8.5 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
CHEMBL12909 19368 None 0 Human Functional pKd = 8.5 8.5 - 1
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 415 10 1 6 4.9 CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 10.1016/j.bmc.2010.10.043
1610 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3941 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
3961.0 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
590 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
CHEMBL191 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
DB00678 2347 None 64 Human Functional pKd = 8.5 8.5 -10 11
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.bmc.2010.10.043
9801627 52077 None 15 Rabbit Functional pKd = 8.5 8.5 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 409 7 1 6 4.7 CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL158725 52077 None 15 Rabbit Functional pKd = 8.5 8.5 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 409 7 1 6 4.7 CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
17748251 93400 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL245444 93400 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44570266 190924 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 9 2 5 5.9 CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL518388 190924 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 519 9 2 5 5.9 CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
9938452 117979 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 591 13 2 6 8.1 CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
CHEMBL340315 117979 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 591 13 2 6 8.1 CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2010.10.043
17748251 93400 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL245444 93400 None 0 Rabbit Functional pKd = 8.4 8.4 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
44438868 92038 None 0 Rabbit Functional pKd = 7.5 7.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241684 92038 None 0 Rabbit Functional pKd = 7.5 7.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 6 1 8 3.4 CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
44438901 92021 None 0 Rabbit Functional pKd = 6.5 6.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241529 92021 None 0 Rabbit Functional pKd = 6.5 6.5 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 389 6 2 5 3.8 CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1016/j.bmcl.2007.02.042
25112616 185998 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL486848 185998 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL415157 215634 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 10.1021/jm9608669
1610 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
3941 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
3961 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
3961.0 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
590 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
CHEMBL191 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
DB00678 2347 None 64 Rat Functional pKd = 7.4 7.4 -9 11
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/j.ejmech.2007.11.008
25112614 191732 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL519564 191732 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 483 11 2 4 6.9 CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
70686410 76357 None 0 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
CHEMBL2058859 76357 None 0 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hrAntagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post KCl-induction for 1 hr
ChEMBL 555 10 2 6 6.2 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2012.05.056
57380414 70554 None 0 Rabbit Functional pKd = 8.3 8.3 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 70554 None 0 Rabbit Functional pKd = 8.3 8.3 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44339988 161101 None 0 Rabbit Functional pKd = 5.3 5.3 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
CHEMBL411624 161101 None 0 Rabbit Functional pKd = 5.3 5.3 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL 989 27 12 12 -1.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C 10.1021/jm9608669
132562 99737 None 5 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
CHEMBL284536 99737 None 5 Rabbit Functional pKd = 8.3 8.3 - 1
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 407 6 1 5 5.2 CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 10.1016/j.bmc.2010.10.043
53325868 57618 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 515 12 2 6 5.8 CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668002 57618 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic ringsAntagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings
ChEMBL 515 12 2 6 5.8 CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1016/j.bmc.2010.10.043
44438880 92020 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL241523 92020 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 427 7 2 7 3.7 CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
132706 1676 None 20 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
6896 1676 None 20 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
CHEMBL315021 1676 None 20 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
DB01342 1676 None 20 Human Functional pKd = 8.2 8.2 -1 2
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 10.1016/j.bmc.2010.10.043
57380412 70552 None 0 Rabbit Functional pKd = 8.2 8.2 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 70552 None 0 Rabbit Functional pKd = 8.2 8.2 - 2
Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 minsAntagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 60 mins
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44570264 190816 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 10 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL518230 190816 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 10 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
25112617 186863 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL488883 186863 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 537 9 2 4 7.7 CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL268804 213223 None 0 Rabbit Functional pKd = 8.1 8.1 - 0
Negative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aortaNegative log of the dose of antagonist (compound) that reduces response of a double dose of Angiotensin II receptor, type 1 to that of a single dose, on rabbit aorta
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C 10.1021/jm9608669
44438872 169209 None 0 Rabbit Functional pKd = 7.1 7.1 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
CHEMBL440051 169209 None 0 Rabbit Functional pKd = 7.1 7.1 - 1
Antagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic ringsAntagonist activity at AT1 receptor assessed inhibition of angiotensin-2-induced contraction of rabbit thoracic aortic rings
ChEMBL 455 8 1 8 4.2 CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2007.02.042
15069306 179168 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 469 10 2 4 6.5 CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
CHEMBL471505 179168 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortaAntagonist activity at AT1 receptor in rat aorta
ChEMBL 469 10 2 4 6.5 CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2007.11.008
44570217 183340 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 11 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL479626 183340 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 505 11 2 5 5.5 CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
44570216 190166 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 491 10 2 5 5.1 CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
CHEMBL517230 190166 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at AT1 receptor in rat aortic ringsAntagonist activity at AT1 receptor in rat aortic rings
ChEMBL 491 10 2 5 5.1 CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.bmc.2008.10.056
6918269 98523 None 10 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL275875 98523 None 10 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL295959 98523 None 10 Rabbit Functional pKd = 8.0 8.0 - 2
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 508 9 1 7 5.5 CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
1610 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3941 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961.0 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
590 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
CHEMBL191 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
DB00678 2347 None 64 Rat Functional pKi = 8.1 8.1 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
1610 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3941 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
3961.0 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
590 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
CHEMBL191 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
DB00678 2347 None 64 Rat Functional pKi = 7.0 7.0 -19 11
In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranesIn vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membranes
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00103a014
6917 132 None 0 Human Functional pA2 = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
73755250 132 None 0 Human Functional pA2 = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
11943 3875 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
145925549 3875 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
CHEMBL4438122 3875 None 0 Human Functional pEC50 = 5.7 5.7 -14 2
β-arrestin recruitment assayβ-arrestin recruitment assay
Guide to Pharmacology None None None None None
123814 421 None 29 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
5368 421 None 29 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
CHEMBL261120 421 None 29 Human Functional pEC50 = 5.9 5.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12006574
6894 418 None 0 Human Functional pEC50 = 8.2 8.2 -56 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 418 None 0 Human Functional pEC50 = 8.2 8.2 -56 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6905 3485 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7499361
135409642 220221 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
135409642.0 220221 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
CHEMBL2028661 220221 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
DB08822 220221 None 0 Bovine Functional pIC50 = 8.2 8.2 1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
2540 4402 None 68 Bovine Functional pIC50 = 8.2 8.2 1 28
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
CHEMBL1014 4402 None 68 Bovine Functional pIC50 = 8.2 8.2 1 28
NoneNone
Drug Central 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 None
3839 3757 None 53 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
60919 3757 None 53 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
6898 3757 None 53 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
CHEMBL432162 3757 None 53 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
DB01349 3757 None 53 Human Functional pIC50 = 8.1 8.1 794 2
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
Drug Central 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 None
130881 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
130881.0 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
1985 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
591 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
CHEMBL1200692 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
DB00275 2921 None 65 Bovine Functional pIC50 = 8.1 8.1 -2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
130881 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
130881.0 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
1985 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
591 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
CHEMBL1200692 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
DB00275 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
NoneNone
Drug Central 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C None
135409642 220221 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
135409642.0 220221 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
CHEMBL2028661 220221 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
DB08822 220221 None 0 Human Functional pIC50 = 8.1 8.1 -1 2
NoneNone
Drug Central 568 9 1 11 4.7 CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 None
16133225 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
172198 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
172198.0 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
2504 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
45266664 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
5272 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
CHEMBL408403 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
DB11842 419 None 38 Human Functional pIC50 = 8.0 8.0 -5 4
NoneNone
Drug Central None None None None None
9870652 70916 None 54 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
9870652.0 70916 None 54 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
CHEMBL1951143 70916 None 54 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
DB09279 70916 None 54 Human Functional pIC50 = 8.0 8.0 -15 2
antagonism of angiotensin II induced contractionantagonism of angiotensin II induced contraction
Drug Central 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 None
1610 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961.0 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 2347 None 64 Human Functional pIC50 = 8.0 8.0 -10 11
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3936 2210 None 32 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
6603900 2210 None 32 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
CHEMBL288174 2210 None 32 Human Functional pIC50 = 7.9 7.9 -1 6
UnclassifiedUnclassified
Guide to Pharmacology 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 7829475
6895 2211 None 0 Human Functional pIC50 = 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 580 9 1 6 6.6 CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C 9383393
73755245 2211 None 0 Human Functional pIC50 = 7.9 7.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 580 9 1 6 6.6 CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C 9383393
1610 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
3941 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
3961 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
3961.0 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
590 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
CHEMBL191 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
DB00678 2347 None 64 Human Functional pIC50 = 8.1 8.1 -10 11
UnclassifiedUnclassified
Guide to Pharmacology 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 8372104
139031070 2839 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
6911 2839 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
73755247 2839 None 0 Human Functional pIC50 = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 714 11 0 10 2.6 CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] 23376252
130881 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
130881.0 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
1985 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
591 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
CHEMBL1200692 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
DB00275 2921 None 65 Human Functional pIC50 = 8.1 8.1 2 3
UnclassifiedUnclassified
Guide to Pharmacology 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 11451212
135415867 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
135415867 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
135415867.0 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
135415867.0 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
6901 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
6901 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
CHEMBL57242 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24739538
CHEMBL57242 560 None 64 Human Functional pIC50 = 8.1 8.1 53 2
UnclassifiedUnclassified
Guide to Pharmacology 456 7 2 7 4.2 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O 24742498
6909 2408 None 0 Human Functional pIC50 = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
73755246 2408 None 0 Human Functional pIC50 = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
10416728 2409 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
6910 2409 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
CHEMBL344662 2409 None 0 Human Functional pIC50 = 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 642 14 4 9 3.7 CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O 11303957
132706 1676 None 20 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
6896 1676 None 20 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
CHEMBL315021 1676 None 20 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
DB01342 1676 None 20 Rat Functional pIC50 = 8.4 8.4 1 2
UnclassifiedUnclassified
Guide to Pharmacology 416 10 1 7 4.3 CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC 7505365
2583 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
592 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
65999 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
65999.0 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
CHEMBL1017 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
DB00966 3776 None 69 Human Functional pIC50 = 8.4 8.4 -1 16
UnclassifiedUnclassified
Guide to Pharmacology 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 9878991
4673492 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
8324 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
CHEMBL159096 4138 None 6 Guinea pig Functional pIC50 = 8.4 8.4 -6 3
UnclassifiedUnclassified
Guide to Pharmacology 438 6 1 5 4.5 CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 8576904
108185 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
108185 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
586 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
586 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
CHEMBL907 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10193788
CHEMBL907 1614 None 50 Human Functional pIC50 = 8.4 8.4 3 5
UnclassifiedUnclassified
Guide to Pharmacology 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 8372104
44299731 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
585 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
CHEMBL56448 420 None 0 Human Functional pIC50 = 8.5 8.5 -2 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
6917 132 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
73755250 132 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 348 7 1 3 4.9 CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O 22889560
1037 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
3940 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
5281037 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
5281037.0 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
588 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
CHEMBL813 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
DB00876 1578 None 44 Human Functional pIC50 = 8.6 8.6 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 1309870
2806 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
3937 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
593 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
60846 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
60846.0 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
CHEMBL1069 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
DB00177 3969 None 65 Human Functional pIC50 = 8.6 8.6 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 8577935
1481 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
3749 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
3749.0 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
589 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
6908 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
CHEMBL1513 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
DB01029 2066 None 66 Human Functional pIC50 = 8.8 8.8 -2 6
UnclassifiedUnclassified
Guide to Pharmacology 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10193788
136218976 150 None 0 Rat Functional pIC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
6913 150 None 0 Rat Functional pIC50 = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 423 9 2 5 3.7 CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O 22410249
2806 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
3937 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
593 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
60846 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
60846.0 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
CHEMBL1069 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
DB00177 3969 None 65 Human Functional pIC50 = 8.9 8.9 1 4
UnclassifiedUnclassified
Guide to Pharmacology 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 11206708
3839 3757 None 53 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
60919 3757 None 53 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
6898 3757 None 53 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
CHEMBL432162 3757 None 53 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
DB01349 3757 None 53 Human Functional pIC50 = 8.9 8.9 794 2
UnclassifiedUnclassified
Guide to Pharmacology 411 4 1 6 3.4 Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 11046101
16133225 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
172198 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
172198.0 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
2504 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
45266664 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
5272 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
CHEMBL408403 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
DB11842 419 None 38 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10193788
6894 418 None 0 Rat Functional pIC50 = 9.5 9.5 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 418 None 0 Rat Functional pIC50 = 9.5 9.5 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
2541 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
2541.0 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
587 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
6907 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
CHEMBL1016 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
DB00796 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788
DB13919 786 None 65 Human Functional pIC50 = 9.6 9.6 15 10
UnclassifiedUnclassified
Guide to Pharmacology 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10193788




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2541 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
2541.0 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 786 None 65 Human Binding pAC50 = 9.4 9.4 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
158781 44180 None 60 Human Binding pAC50 = 9.4 9.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 44180 None 60 Human Binding pAC50 = 9.4 9.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
2541 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
2541.0 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 786 None 65 Human Binding pAC50 = 9.3 9.3 -1 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
1481 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749.0 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
158781 44180 None 60 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 44180 None 60 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
1481 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749.0 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2066 None 66 Human Binding pAC50 = 9.1 9.1 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
130881 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
130881.0 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 2921 None 65 Human Binding pAC50 = 9.1 9.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
2583 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
592 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
65999.0 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
CHEMBL1017 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
DB00966 3776 None 69 Human Binding pAC50 = 9 9.0 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1038/s41467-023-40064-9
1481 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749.0 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 2066 None 66 Human Binding pAC50 = 8.8 8.8 1 3
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
130881 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
130881.0 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 2921 None 65 Human Binding pAC50 = 8.8 8.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1037 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037.0 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1578 None 44 Human Binding pAC50 = 8.7 8.7 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
242 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795.0 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 470 None 70 Human Binding pAC50 = 6 6.0 - 51
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
216239 23803 None 71 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1200485 23803 None 71 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
CHEMBL1336 23803 None 71 Human Binding pAC50 = 5.0 5.0 - 7
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 10.1038/s41467-023-40064-9
25181577 78248 None 44 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
CHEMBL2105695 78248 None 44 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 574 9 2 9 5.0 CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 10.1038/s41467-023-40064-9
54682461 84720 None 41 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
CHEMBL222559 84720 None 41 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 602 11 2 6 7.3 CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 10.1038/s41467-023-40064-9
441290 14483 None 21 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
441290.0 14483 None 21 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
CHEMBL1201244 14483 None 21 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
DB00728 14483 None 21 Human Binding pAC50 = 5.9 5.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 5 1 5 4.4 C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 10.1038/s41467-023-40064-9
65948 18563 None 62 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
CHEMBL1275868 18563 None 62 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 582 9 2 9 4.7 CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 10.1038/s41467-023-40064-9
5077 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
7552 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9913767.0 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL238804 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
DB11362 3578 None 61 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
64139 84819 None 58 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84819 None 58 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
2540 4402 None 68 Human Binding pAC50 = 7.9 7.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4402 None 68 Human Binding pAC50 = 7.9 7.9 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
180 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
200 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
2160.0 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
CHEMBL629 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
DB00321 401 None 38 Human Binding pAC50 = 5.9 5.9 - 39
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C 10.1038/s41467-023-40064-9
3149 12618 None 11 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 12618 None 11 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
1549120 198942 None 55 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56337 198942 None 55 Human Binding pAC50 = 5.8 5.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 4 1 4 2.9 CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 10.1038/s41467-023-40064-9
5281034 14431 None 18 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
CHEMBL1200585 14431 None 18 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 332 0 2 3 4.4 C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O 10.1038/s41467-023-40064-9
3599 16886 None 60 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
CHEMBL125 16886 None 60 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 20 0 4 5.7 CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C 10.1038/s41467-023-40064-9
5591 157623 None 57 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
CHEMBL408 157623 None 57 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 5 2 6 4.4 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 10.1038/s41467-023-40064-9
3152 188518 None 61 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 0 4 4.4 COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 10.1038/s41467-023-40064-9
CHEMBL502 188518 None 61 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 379 6 0 4 4.4 COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 10.1038/s41467-023-40064-9
2333 142422 None 66 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
CHEMBL388590 142422 None 66 Human Binding pAC50 = 4.8 4.8 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 3 1 3 5.5 CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 10.1038/s41467-023-40064-9
5803 162321 None 58 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
CHEMBL41632 162321 None 58 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 622 4 2 3 4.6 O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 10.1038/s41467-023-40064-9
104850 3330 None 58 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3330 None 58 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3330 None 58 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3330 None 58 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3330 None 58 Human Binding pAC50 = 4.8 4.8 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
2540 4402 None 68 Human Binding pAC50 = 7.8 7.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4402 None 68 Human Binding pAC50 = 7.8 7.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
5852 2617 None 48 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
9931891 2617 None 48 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
CHEMBL239226 2617 None 48 Human Binding pAC50 = 4.8 4.8 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1038/s41467-023-40064-9
5318 15583 None 40 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1200348 15583 None 40 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1221 15583 None 40 Human Binding pAC50 = 4.8 4.8 - 13
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 10.1038/s41467-023-40064-9
1385580 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
4615.0 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
CHEMBL13828 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
DB12877 29284 None 49 Human Binding pAC50 = 4.8 4.8 - 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 7 1 4 4.1 O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 10.1038/s41467-023-40064-9
1056 3371 None 67 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
2405 3371 None 67 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
77999 3371 None 67 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
CHEMBL121 3371 None 67 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
DB00412 3371 None 67 Human Binding pAC50 = 4.8 4.8 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 1 6 2.5 O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C 10.1038/s41467-023-40064-9
40973 46049 None 50 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1533 46049 None 50 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
135409453 3773 None 26 Human Binding pAC50 = 5.8 5.8 - 19
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 3773 None 26 Human Binding pAC50 = 5.8 5.8 - 19
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 3773 None 26 Human Binding pAC50 = 5.8 5.8 - 19
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
3516 210582 None 66 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 198 5 2 4 0.4 COc1ccccc1OCC(O)CO 10.1038/s41467-023-40064-9
CHEMBL980 210582 None 66 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 198 5 2 4 0.4 COc1ccccc1OCC(O)CO 10.1038/s41467-023-40064-9
135398735 137055 None 20 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 137055 None 20 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 137055 None 20 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
72093 35070 None 5 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 35070 None 5 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 35070 None 5 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
4495 198991 None 63 Human Binding pAC50 = 4.7 4.7 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL56367 198991 None 63 Human Binding pAC50 = 4.7 4.7 - 30
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 10.1038/s41467-023-40064-9
2303 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
4946 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
564 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
63 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
91536 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL27 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
CHEMBL452861 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
DB00571 3187 None 44 Human Binding pAC50 = 4.7 4.7 - 26
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 259 6 2 3 2.6 O[C@H](COc1cccc2c1cccc2)CNC(C)C 10.1038/s41467-023-40064-9
25025298 78180 None 37 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
CHEMBL2103855 78180 None 37 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 546 8 3 8 4.5 Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 10.1038/s41467-023-40064-9
5280453 208429 None 49 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL846 208429 None 49 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 416 6 3 3 5.7 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
54454 5260 None 48 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL1064 5260 None 48 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 418 6 1 5 4.6 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
6540478 14453 None 25 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1200934 14453 None 25 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 2 1 4 4.7 C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC 10.1038/s41467-023-40064-9
51755 57422 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 57422 None 40 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
1353 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559.0 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 1911 None 63 Human Binding pAC50 = 4.6 4.6 -6918 85
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
11980903 14498 None 13 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 14498 None 13 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 14498 None 13 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 14498 None 13 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5564 208464 None 69 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 288 2 1 2 5.1 Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL849 208464 None 69 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 288 2 1 2 5.1 Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl 10.1038/s41467-023-40064-9
3899 210233 None 68 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL960 210233 None 68 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
24826799 10802 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
CHEMBL1171837 10802 None 64 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 532 4 1 6 4.5 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 10.1038/s41467-023-40064-9
2335 11852 None 18 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 11852 None 18 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 11852 None 18 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 11852 None 18 Human Binding pAC50 = 4.6 4.6 - 12
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
2585 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2585.0 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 803 None 59 Human Binding pAC50 = 6.6 6.6 - 22
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
1610 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961.0 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 None 64 Human Binding pAC50 = 7.6 7.6 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
16220172 73068 None 63 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
CHEMBL2010601 73068 None 63 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 392 2 3 3 5.1 CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O 10.1038/s41467-023-40064-9
3926 209699 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
CHEMBL92870 209699 None 30 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 491 9 1 3 5.8 Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1038/s41467-023-40064-9
54585 14508 None 49 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
CHEMBL1201346 14508 None 49 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 357 7 4 6 2.7 O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 10.1038/s41467-023-40064-9
2812 4781 None 63 Human Binding pAC50 = 4.6 4.6 - 34
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL104 4781 None 63 Human Binding pAC50 = 4.6 4.6 - 34
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
11626560 203394 None 56 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
CHEMBL601719 203394 None 56 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
47472 19444 None 41 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1295 19444 None 41 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 410 7 0 3 6.6 Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 10.1038/s41467-023-40064-9
16362 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
16362.0 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
2172 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
90 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
CHEMBL1423 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
DB01100 3125 None 49 Human Binding pAC50 = 4.5 4.5 - 29
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 10.1038/s41467-023-40064-9
392622 56328 None 57 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 56328 None 57 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
4485 69401 None 70 Human Binding pAC50 = 4.4 4.4 - 8
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
CHEMBL193 69401 None 70 Human Binding pAC50 = 4.4 4.4 - 8
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 1 7 2.2 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] 10.1038/s41467-023-40064-9
53232 188732 None 57 Human Binding pAC50 = 4.4 4.4 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
CHEMBL503 188732 None 57 Human Binding pAC50 = 4.4 4.4 - 2
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 10.1038/s41467-023-40064-9
1037 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037.0 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1578 None 44 Human Binding pAC50 = 8.4 8.4 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5329102 194838 None 50 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 194838 None 50 Human Binding pAC50 = 5.4 5.4 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
1037 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037.0 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
1610 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961.0 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 None 64 Human Binding pAC50 = 8.3 8.3 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
1037 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
3940 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
5281037.0 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
588 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
CHEMBL813 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
DB00876 1578 None 44 Human Binding pAC50 = 8.3 8.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1038/s41467-023-40064-9
2855 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3322 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
5717.0 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
CHEMBL603 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
DB00549 4132 None 63 Human Binding pAC50 = 4.3 4.3 - 6
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C 10.1038/s41467-023-40064-9
3333 40181 None 69 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
CHEMBL1480 40181 None 69 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 5 4.0 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl 10.1038/s41467-023-40064-9
41684 31229 None 62 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31229 None 62 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
146015366 210861 None 45 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
60852 210861 None 45 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
CHEMBL997 210861 None 45 Human Binding pAC50 = 5.2 5.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 319 9 5 4 0.5 CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O 10.1038/s41467-023-40064-9
275196 125740 None 38 Human Binding pAC50 = 6.2 6.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL2106732 125740 None 38 Human Binding pAC50 = 6.2 6.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
CHEMBL364713 125740 None 38 Human Binding pAC50 = 6.2 6.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 4 0 8 2.9 COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C 10.1038/s41467-023-40064-9
4494 190296 None 55 Human Binding pAC50 = 4.2 4.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL517427 190296 None 55 Human Binding pAC50 = 4.2 4.2 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
5282219 35878 None 48 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
CHEMBL1441961 35878 None 48 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 450 12 1 5 5.7 CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 10.1038/s41467-023-40064-9
135565674 195116 None 61 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
213023 195116 None 61 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
6445226 195116 None 61 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
9578572 195116 None 61 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
CHEMBL539697 195116 None 61 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 627 15 3 10 5.8 CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 10.1038/s41467-023-40064-9
4209 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
4893 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
4893.0 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
503 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
5385 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
CHEMBL2 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
DB00457 3163 None 48 Human Binding pAC50 = 5.1 5.1 - 35
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1038/s41467-023-40064-9
5282181 53539 None 37 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL1601669 53539 None 37 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 400 6 2 2 6.6 C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O 10.1038/s41467-023-40064-9
CHEMBL5314356 194706 None 0 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL None None None None 10.1038/s41467-023-40064-9
135564886 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14499 None 5 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
1610 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961.0 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 2347 None 64 Human Binding pAC50 = 8 8.0 1 5
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
2194 63103 None 64 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 63103 None 64 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
71329 179375 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 11 2 6 2.0 CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
CHEMBL473 179375 None 61 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 441 11 2 6 2.0 CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 10.1038/s41467-023-40064-9
155540547 172624 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 172624 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155539027 172927 None 0 Rat Binding pEC50 = 8 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 172927 None 0 Rat Binding pEC50 = 8 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155541295 173114 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173114 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155547844 173802 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 173802 None 0 Human Binding pEC50 = 7 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155565112 175603 None 0 Rat Binding pEC50 = 7 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 175603 None 0 Rat Binding pEC50 = 7 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 173655 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 173655 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568289 176231 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 176231 None 0 Human Binding pEC50 = 6 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155557139 174648 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 174648 None 0 Human Binding pEC50 = 5 5.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520024 173350 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 173350 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155557139 174648 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4556070 174648 None 0 Rat Binding pEC50 = 5 5.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL938 218397 None 23 Human Binding pEC50 = 8.0 8.0 1 2
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155544988 173546 None 0 Rat Binding pEC50 = 7.0 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 173546 None 0 Rat Binding pEC50 = 7.0 7.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155541440 173122 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173122 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155540033 172993 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172993 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155541125 173068 None 0 Rat Binding pEC50 = 6.9 6.9 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 173068 None 0 Rat Binding pEC50 = 6.9 6.9 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155540470 172579 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 172579 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559120 174890 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 174890 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155564502 175364 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175364 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54696627 98399 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
CHEMBL27511 98399 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 10.1016/S0960-894X(01)81134-3
54726669 99324 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
CHEMBL281887 99324 None 0 Bovine Binding pEC50 = 5.9 5.9 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 10.1016/S0960-894X(01)81134-3
155539027 172927 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4514079 172927 None 0 Human Binding pEC50 = 7.9 7.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547428 173719 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173719 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 174378 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 174378 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543091 173283 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 173283 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155520014 173339 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 173339 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2028943 211594 None 0 Rat Binding pEC50 = 7.9 7.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
CHEMBL2370909 212407 None 0 Rat Binding pEC50 = 6.9 6.9 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155542907 173280 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173280 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155563676 175448 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 175448 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2392353 212873 None 5 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
3082475 3877 None 19 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3877 None 19 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3877 None 19 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3877 None 19 Rat Binding pEC50 = 7.8 7.8 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155568804 176224 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 176224 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155541240 173119 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 173119 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 175404 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175404 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155554529 174737 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 174737 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
10533900 176073 None 11 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 176073 None 11 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155544246 173470 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 173470 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553003 174180 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174180 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155561477 175296 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 175296 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 175325 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 175325 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155553930 175545 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175545 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155551279 174091 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
CHEMBL4542269 174091 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL 877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O 10.1021/acs.jmedchem.8b00435
3082475 3877 None 19 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
6902 3877 None 19 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4297447 3877 None 19 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB12199 3877 None 19 Human Binding pEC50 = 7.8 7.8 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
70538373 175602 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 175602 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
155554865 174458 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174458 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
54726671 94676 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL25226 94676 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155560095 175026 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 175026 None 0 Rat Binding pEC50 = 7.8 7.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155563538 175404 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175404 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155565687 175687 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 175687 None 0 Rat Binding pEC50 = 6.8 6.8 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556507 174590 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174590 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726670 94017 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL24842 94017 None 0 Bovine Binding pEC50 = 5.8 5.8 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155560463 175144 None 0 Rat Binding pEC50 = 7.7 7.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175144 None 0 Rat Binding pEC50 = 7.7 7.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 174180 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174180 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
155554865 174458 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174458 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155564502 175364 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175364 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155560463 175144 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175144 None 0 Human Binding pEC50 = 7.7 7.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155551762 174114 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 174114 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155552995 174216 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 174216 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155556530 174615 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174615 None 0 Rat Binding pEC50 = 6.7 6.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155568109 176143 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 176143 None 0 Human Binding pEC50 = 5.7 5.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL2392353 212873 None 5 Human Binding pEC50 = 7.7 7.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155556530 174615 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174615 None 0 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
11944 3876 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3876 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3876 None 0 Human Binding pEC50 = 5.7 5.7 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540470 172579 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4482867 172579 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553311 174237 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 174237 None 0 Rat Binding pEC50 = 5.7 5.7 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 176093 None 11 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 176093 None 11 Human Binding pEC50 = 6.7 6.7 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
54726676 99281 None 0 Bovine Binding pEC50 = 5.7 5.7 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28162 99281 None 0 Bovine Binding pEC50 = 5.7 5.7 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155540328 173004 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 173004 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155547428 173719 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173719 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155568318 176206 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 176206 None 0 Human Binding pEC50 = 7.6 7.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155559827 175019 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 175019 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155565112 175603 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4577692 175603 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558784 174880 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174880 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155540639 173036 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 173036 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553479 174282 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174282 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558428 174833 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174833 None 0 Rat Binding pEC50 = 7.6 7.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155553479 174282 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174282 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155543972 175119 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 175119 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 176157 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 176157 None 0 Rat Binding pEC50 = 6.6 6.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155556507 174590 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174590 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
130762 98300 None 4 Bovine Binding pEC50 = 5.6 5.6 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL274447 98300 None 4 Bovine Binding pEC50 = 5.6 5.6 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/S0960-894X(01)81134-3
155568109 176143 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590381 176143 None 0 Rat Binding pEC50 = 5.6 5.6 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL77838 218368 None 5 Human Binding pEC50 = 8.5 8.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155558428 174833 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174833 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155560095 175026 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4564950 175026 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155548506 173858 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 173858 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155569246 176287 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 176287 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155568804 176224 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4591857 176224 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155568318 176206 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4591448 176206 None 0 Rat Binding pEC50 = 7.5 7.5 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155543091 173283 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4522246 173283 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155550799 174378 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4549405 174378 None 0 Human Binding pEC50 = 7.5 7.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 173036 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 173036 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155544988 173546 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
CHEMBL4529051 173546 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O nan
155565687 175687 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4579604 175687 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
1610 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3941 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3961 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
3961.0 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
590 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
CHEMBL191 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
DB00678 2347 None 64 Bovine Binding pEC50 = 6.5 6.5 - 5
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(01)81134-3
155563973 175465 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4574655 175465 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155541295 173114 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173114 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
145925550 175576 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 175576 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155539838 172998 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172998 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
11943 3875 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3875 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3875 None 0 Rat Binding pEC50 = 7.4 7.4 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155540033 172993 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172993 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155520014 173339 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524300 173339 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL312754 213569 None 13 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155548506 173858 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL4536886 173858 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155548148 173819 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 173819 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155554529 174737 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4557984 174737 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 175850 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175850 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558003 174797 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174797 None 0 Rat Binding pEC50 = 5.4 5.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
70538373 175602 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
CHEMBL4577691 175602 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C nan
154573825 176093 None 11 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 176093 None 11 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155561477 175296 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4570840 175296 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559104 174910 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174910 None 0 Rat Binding pEC50 = 7.4 7.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155552475 174156 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174156 None 0 Human Binding pEC50 = 6.4 6.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155560024 174994 None 0 Rat Binding pEC50 = 4.4 4.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174994 None 0 Rat Binding pEC50 = 4.4 4.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
11943 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
145925549 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
CHEMBL4438122 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00435
11943 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
145925549 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4438122 3875 None 0 Human Binding pEC50 = 7.4 7.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155542907 173280 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173280 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
155541125 173068 None 0 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 173068 None 0 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
155552475 174156 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174156 None 0 Rat Binding pEC50 = 6.4 6.4 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155561376 175779 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 175779 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155560024 174994 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4564094 174994 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155553098 174214 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174214 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155553311 174237 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4546162 174237 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155540547 172624 None 0 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4483576 172624 None 0 Rat Binding pEC50 = 8.3 8.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155548148 173819 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4535997 173819 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155551762 174114 None 0 Rat Binding pEC50 = 7.3 7.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4542709 174114 None 0 Rat Binding pEC50 = 7.3 7.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155546362 173655 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4532075 173655 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553930 175545 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175545 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
54726675 99428 None 0 Bovine Binding pEC50 = 6.3 6.3 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282566 99428 None 0 Bovine Binding pEC50 = 6.3 6.3 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
155558003 174797 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174797 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
86727577 116040 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
CHEMBL3355127 116040 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 10.1021/jm5013006
155555310 174463 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 174463 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155555310 174463 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4551431 174463 None 0 Rat Binding pEC50 = 6.3 6.3 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
10533900 176073 None 11 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 176073 None 11 Human Binding pEC50 = 6.3 6.3 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
90219582 116041 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
CHEMBL3355137 116041 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
ChEMBL 436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 10.1021/jm5013006
155552995 174216 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4545399 174216 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL77838 218368 None 5 Rat Binding pEC50 = 8.2 8.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
16133225 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198.0 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 419 None 38 Rat Binding pEC50 = 8.2 8.2 - 4
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726672 99361 None 0 Bovine Binding pEC50 = 6.2 6.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL282082 99361 None 0 Bovine Binding pEC50 = 6.2 6.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/S0960-894X(01)81134-3
54726668 97298 None 0 Bovine Binding pEC50 = 5.2 5.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
CHEMBL26875 97298 None 0 Bovine Binding pEC50 = 5.2 5.2 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81134-3
155559827 175019 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4564617 175019 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155539838 172998 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172998 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547844 173802 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4535678 173802 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155553098 174214 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174214 None 0 Rat Binding pEC50 = 7.2 7.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155566196 175850 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175850 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155567790 176157 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4590589 176157 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155562469 175325 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
CHEMBL4571382 175325 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 nan
155568289 176231 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4592000 176231 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155544246 173470 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4527484 173470 None 0 Rat Binding pEC50 = 6.2 6.2 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155520024 173350 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4524570 173350 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155558784 174880 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174880 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155543972 175119 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4567103 175119 None 0 Human Binding pEC50 = 6.2 6.2 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL938 218397 None 23 Rat Binding pEC50 = 8.1 8.1 - 2
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
155552886 174200 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 174200 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155552886 174200 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4544902 174200 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
145925550 175576 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4577270 175576 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
155559104 174910 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174910 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155541240 173119 None 0 Rat Binding pEC50 = 7.1 7.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4518420 173119 None 0 Rat Binding pEC50 = 7.1 7.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2028943 211594 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552429 174261 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 174261 None 0 Rat Binding pEC50 = 8.1 8.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
155540328 173004 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 173004 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155563676 175448 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4574199 175448 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155559120 174890 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4561769 174890 None 0 Rat Binding pEC50 = 6.1 6.1 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2370909 212407 None 0 Human Binding pEC50 = 6.1 6.1 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552429 174261 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL4546799 174261 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C nan
CHEMBL312754 213569 None 13 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155541440 173122 None 0 Rat Binding pEC50 = 8.0 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173122 None 0 Rat Binding pEC50 = 8.0 8.0 - 0
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
16133225 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
172198.0 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
2504 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
45266664 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
5272 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL408403 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
DB11842 419 None 38 Human Binding pEC50 = 8.0 8.0 -1 4
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
54726674 99784 None 0 Bovine Binding pEC50 = 7.1 7.1 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
CHEMBL284877 99784 None 0 Bovine Binding pEC50 = 7.1 7.1 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 10.1016/S0960-894X(01)81134-3
11944 3876 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155552190 3876 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
CHEMBL4544228 3876 None 0 Rat Binding pEC50 = 6.0 6.0 - 1
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL None None None None nan
155558059 174787 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174787 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155569246 176287 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4593310 176287 None 0 Human Binding pEC50 = 7.0 7.0 - 0
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
ChEMBL 869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
54726673 99277 None 0 Bovine Binding pEC50 = 5.0 5.0 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
CHEMBL28160 99277 None 0 Bovine Binding pEC50 = 5.0 5.0 - 0
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
ChEMBL 477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/S0960-894X(01)81134-3
10032858 29769 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL138690 29769 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1007/s00044-013-0831-x
10032858 29769 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 29769 None 0 Rabbit Binding pIC50 = 10.4 10.4 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9895212 119704 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 119704 None 0 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
10417251 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL265797 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10417251 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10417251 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 96958 None 0 Rabbit Binding pIC50 = 10.3 10.3 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10349732 118817 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL341828 118817 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10032820 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10032820 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349732 118817 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 118817 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10032820 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339672 117368 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10439848 119274 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343309 119274 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439848 119274 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 119274 None 0 Rabbit Binding pIC50 = 10.1 10.1 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010071 117413 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339722 117413 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9829012 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44311455 102799 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 102799 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 102834 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 102834 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 103116 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 103116 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311435 206480 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 206480 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 206543 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 206543 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 206582 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 206582 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 206644 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 206644 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 206658 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 206658 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 206681 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 206681 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9829012 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
73347893 92679 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 92679 None 0 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9829012 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
CHEMBL24322 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80335-2
19754061 102789 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 102789 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44309719 206312 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 206312 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10010071 117413 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 117413 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9829012 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24322 92608 None 0 Rabbit Binding pIC50 = 10 10.0 - 0
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
9829012 92608 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 92608 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9809961 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL316300 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10439862 118836 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL341934 118836 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10010195 119248 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL343142 119248 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
9809961 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9917295 103013 None 18 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 103013 None 18 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
9809961 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
9809961 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 107217 None 2 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439862 118836 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 118836 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 119248 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 119248 None 0 Rabbit Binding pIC50 = 10.0 10.0 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10395394 31888 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL140708 31888 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10032851 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
9809637 206310 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 206310 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
10032851 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 31888 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 31888 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44210588 120409 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 120409 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10032851 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL124771 16842 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113955 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
CHEMBL332576 113955 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1007/s00044-011-9815-x
10395335 117146 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
CHEMBL339256 117146 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1007/s00044-011-9815-x
10372451 117358 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL339605 117358 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10327309 113955 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 113955 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10395335 117146 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 117146 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372451 117358 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 117358 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372093 112825 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 112825 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44314822 103004 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 103004 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10259411 30666 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL139452 30666 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10485116 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL338101 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
10462598 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
CHEMBL332909 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
10485116 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338101 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
10395076 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL435811 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
10462598 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10485116 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10395076 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 168679 None 0 Human Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 168679 None 0 Human Binding pIC50 = 9.9 9.9 - 0
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259411 30666 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 30666 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485116 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
10462598 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
CHEMBL332909 114200 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1007/s00044-011-9815-x
10485116 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338101 116917 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-011-9815-x
10395076 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
CHEMBL435811 168679 None 0 Rabbit Binding pIC50 = 9.9 9.9 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1007/s00044-011-9815-x
19939453 112454 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 112454 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10326797 210033 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 210033 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
44381724 120372 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 120372 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381671 120491 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 120491 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259395 27003 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
CHEMBL136465 27003 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1007/s00044-013-0831-x
10078663 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
CHEMBL96075 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1007/s00044-013-0831-x
9853391 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338027 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101608 117093 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL339004 117093 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10078663 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
9853391 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 117093 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 117093 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10009273 107281 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 107281 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
10259395 27003 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 27003 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078663 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 210246 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44327716 107370 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl 10.1016/S0960-894X(01)81116-1
CHEMBL317343 107370 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
ChEMBL 492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl 10.1016/S0960-894X(01)81116-1
9853391 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
CHEMBL338027 116903 None 1 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1007/s00044-011-9815-x
10101608 117093 None 0 Rabbit Binding pIC50 = 9.8 9.8 - 0
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist ac