Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
CHEMBL438162 213729 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1262 16 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1262 16 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1262 16 None -2 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL437201 213687 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL441576 213867 0 None - 1 Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1262 16 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1262 16 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1262 16 None -2 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
1491 2779 13 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL1765705 2779 13 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
44123843 1262 16 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
9166 1262 16 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL230333 1262 16 None 2 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL430024 213583 0 None - 1 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL409981 212770 0 None - 1 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267034 210687 0 None - 1 Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(I)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398483 212501 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1C)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398524 212502 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL390860 212422 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL524693 215597 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL453962 213968 0 None - 1 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL2372117 210165 0 None - 1 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]1(NC(=O)[C@@H](N)CO)CCc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1262 16 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
9166 1262 16 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL230333 1262 16 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL499957 214082 0 None - 1 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL506383 214186 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
5810 1344 0 None 3 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL526355 1344 0 None 3 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL401641 212504 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL525447 215628 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL437838 213712 0 None - 1 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL409555 212745 0 None - 1 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL500802 214105 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL396531 212475 0 None - 1 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL447434 213927 0 None - 1 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL500443 214089 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526551 215670 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL428331 213416 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL267266 210694 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267479 210699 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL439309 213814 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1262 16 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
9166 1262 16 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL230333 1262 16 None 2 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL525809 215639 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL400369 212503 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437199 213686 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437389 213693 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510673 215563 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL230108 209437 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL448242 213931 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN/C(N)=N/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524688 215596 0 None - 1 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None C/N=C(/NC)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL526323 215655 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL437764 213710 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL438866 213780 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL505996 214177 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL438115 213728 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL229994 209436 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL507664 214432 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CCC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1021/jm900604g
CHEMBL263801 210566 0 None - 1 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL252537 210485 0 None - 1 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL411392 212859 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510338 215560 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524654 215590 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL411571 212873 0 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C1(NC(=O)[C@@H](N)CO)Cc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL503441 214142 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL413849 213069 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1262 16 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
9166 1262 16 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL230333 1262 16 None 2 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL505174 214166 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL451444 213946 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL425840 213317 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
5811 1500 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL505657 1500 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL500458 214091 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)c1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526492 215663 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL525398 215623 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL509091 215261 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)[C@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL427638 213336 0 None - 1 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL268436 210730 0 None - 1 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
44580138 193341 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL525031 193341 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL507881 214564 0 None - 1 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL503354 214141 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
44123843 1262 16 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
9166 1262 16 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL230333 1262 16 None 2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
44634573 2728 1 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2728 1 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2728 1 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2728 1 None 67 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
44156964 3223 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3223 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3223 0 None 6 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
11177829 178845 2 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
CHEMBL469696 178845 2 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
50925457 19193 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
CHEMBL1290004 19193 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
44156964 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
44156964 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3223 0 None 6 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
50925457 19193 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
CHEMBL1290004 19193 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
44634570 44052 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 44052 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
49863070 15166 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210411 15166 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634512 35024 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL1433323 35024 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL3086835 35024 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
54578636 106488 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106488 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106488 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
46202039 63698 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801330 63698 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578634 106478 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106478 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106478 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
56676662 63701 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
CHEMBL1801333 63701 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
46907769 55591 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55591 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55591 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
44634561 48067 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 48067 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 48067 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
54578863 106454 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 106454 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 106454 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56676661 63699 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801331 63699 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206934 63688 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801320 63688 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659485 63695 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801327 63695 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56683317 63702 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801334 63702 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
49863016 15161 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210311 15161 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
76320765 103528 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103528 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
49862985 15154 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210243 15154 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
46202040 63697 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801329 63697 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669801 63727 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801362 63727 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669836 63692 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801324 63692 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
56659483 63685 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801317 63685 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862947 15143 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210178 15143 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL267479 210699 0 None - 1 Mouse 5.8 pIC50 = 5.8 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
46206599 63679 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63679 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578638 106468 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106468 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106468 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
3278392 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21320 3 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
56679981 63690 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801322 63690 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
46208464 15142 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210177 15142 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
44634570 44052 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 44052 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
50925456 19148 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
CHEMBL1289677 19148 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
54578634 106478 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106478 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106478 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
44634508 55139 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 55139 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 55139 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
72735980 106486 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106486 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106486 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202042 63693 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801325 63693 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
49863017 15162 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210312 15162 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578860 106502 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106502 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106502 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
44156964 3223 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3223 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3223 0 None 6 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
54578862 106444 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 106444 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 106444 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
56666419 63706 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
CHEMBL1801338 63706 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
44634578 55777 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55777 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55777 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55777 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
52944769 19165 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
CHEMBL1289780 19165 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
46205608 63682 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801270 63682 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
11177829 178845 2 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
CHEMBL469696 178845 2 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
8088007 103584 7 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
CHEMBL3086828 103584 7 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
44634521 30587 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1394028 30587 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3570 43 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3570 43 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3570 43 None -3 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
3989078 52326 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
CHEMBL1589741 52326 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
54578636 106488 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106488 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106488 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
54578635 106460 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 106460 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 106460 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
54578637 106490 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106490 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106490 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
49862984 15153 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210242 15153 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
52942771 19129 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
CHEMBL1289571 19129 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
56666418 63691 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801323 63691 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
44634561 48067 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 48067 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 48067 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
46205607 63683 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801271 63683 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862983 15152 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210241 15152 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
72736545 106489 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106489 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106489 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
56676659 63686 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801318 63686 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634514 26273 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
CHEMBL1358647 26273 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
46206933 63681 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801269 63681 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659484 63687 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801319 63687 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46206931 63680 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801268 63680 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206599 63679 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63679 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46189900 63689 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801321 63689 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634578 55777 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55777 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55777 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55777 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
49863071 15167 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210412 15167 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
54578861 106503 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106503 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106503 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
54578861 106503 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106503 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106503 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
44634544 30577 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30577 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
11374217 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3570 43 None -3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
46203026 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
5814 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
CHEMBL1801361 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
46203026 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
5814 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
CHEMBL1801361 3097 1 None 128 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
44634573 2728 1 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2728 1 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2728 1 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2728 1 None 67 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
72736373 106445 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 106445 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 106445 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46206598 63725 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801359 63725 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
76320765 103528 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103528 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
11374217 3570 43 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3570 43 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3570 43 None -3 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
54578638 106468 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106468 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106468 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
56662909 63726 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801360 63726 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
3278392 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21320 3 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL267479 210699 0 None - 1 Mouse 6.3 pIC50 = 6.3 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
44156964 3223 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3223 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3223 0 None 6 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634544 30577 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30577 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
56676660 63694 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801326 63694 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578863 106454 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 106454 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 106454 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56679926 63479 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1800088 63479 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578862 106444 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 106444 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 106444 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
49862986 15155 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210244 15155 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578635 106460 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 106460 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 106460 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
46907769 55591 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55591 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55591 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
49862948 15144 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210179 15144 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634508 55139 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 55139 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 55139 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
44634539 39589 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
CHEMBL1474223 39589 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
44156964 3223 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3223 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3223 0 None 6 2 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
35277770 19149 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
CHEMBL1289678 19149 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
72735980 106486 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106486 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106486 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202376 63724 0 None 85 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801358 63724 0 None 85 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
72736373 106445 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 106445 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 106445 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46202041 63696 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801328 63696 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
72736545 106489 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106489 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106489 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
54578860 106502 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106502 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106502 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
56662946 63705 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801337 63705 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
56676652 63684 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801272 63684 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56662945 63704 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801336 63704 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
54578637 106490 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106490 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106490 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
46907767 55972 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1553073 55972 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1624484 55972 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
56683318 63703 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
CHEMBL1801335 63703 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
56659486 63700 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801332 63700 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
11374217 3570 43 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
5813 3570 43 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL469695 3570 43 None 3 3 Mouse 7.8 pKd = 7.8 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL5077621 214485 0 None - 0 Mouse 7.6 pKd = 7.6 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None O=C(NCc1ccc(F)cc1)N1C[C@H](c2ccccc2)N2C(=O)OC(c3ccccc3)(c3ccccc3)[C@H]2C1 10.1021/acs.jmedchem.0c02223
CHEMBL5091859 215307 0 None - 0 Mouse 7.1 pKd = 7.1 Functional
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None N=C(NCc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/acs.jmedchem.0c02223
6893971 72096 8 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 72096 8 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
6893971 72096 8 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 72096 8 None - 1 Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
73453 29585 24 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29585 24 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
73453 29585 24 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29585 24 None -117 16 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
3739574 19514 17 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
CHEMBL1299616 19514 17 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
3242822 21941 5 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
CHEMBL1320806 21941 5 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
795881 25141 44 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
CHEMBL1347786 25141 44 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
645241 25326 1 None 1584 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
CHEMBL1349430 25326 1 None 1584 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
654157 27321 2 None 1995 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
CHEMBL1367658 27321 2 None 1995 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
44663783 39101 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
660794 39101 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
CHEMBL1469355 39101 15 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
645086 40172 18 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
CHEMBL1480317 40172 18 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
11958558 44836 0 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
CHEMBL1522550 44836 0 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
741701 47717 10 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
CHEMBL1547978 47717 10 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
664554 48041 7 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
CHEMBL1550682 48041 7 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
2093009 52247 6 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
CHEMBL1589089 52247 6 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
653853 54589 8 None 501 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
CHEMBL1610905 54589 8 None 501 2 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
135513617 108860 4 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
CHEMBL3210731 108860 4 None - 1 Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
2930697 20511 8 None 316 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
CHEMBL1307695 20511 8 None 316 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
135521609 22656 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
CHEMBL1327226 22656 4 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
2942941 23949 10 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
CHEMBL1337599 23949 10 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
718615 24077 19 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
CHEMBL1338647 24077 19 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
3159744 24227 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
CHEMBL1340098 24227 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
2767910 29766 16 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
CHEMBL1387210 29766 16 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
3239019 31414 12 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
CHEMBL1402832 31414 12 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
649843 31555 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
CHEMBL1404160 31555 11 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
2011082 34743 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
CHEMBL1430872 34743 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
661165 38813 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
CHEMBL1466877 38813 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
5308493 43247 3 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
CHEMBL1506451 43247 3 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
660432 44285 3 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
CHEMBL1517669 44285 3 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
654643 50066 7 None 199 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
CHEMBL1570008 50066 7 None 199 2 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
3477545 50933 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
CHEMBL1578105 50933 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
1131991 51213 7 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
CHEMBL1580484 51213 7 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
2767561 52026 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
CHEMBL1587194 52026 14 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
2973251 53563 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
CHEMBL1602433 53563 8 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
3939641 54464 5 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
CHEMBL1609794 54464 5 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
12005042 54836 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
CHEMBL1613111 54836 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
1983185 54961 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1335567 54961 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1616085 54961 2 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
4111848 55326 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1387307 55326 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1618998 55326 9 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
5994795 109108 5 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
CHEMBL3213983 109108 5 None - 1 Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
32798 10144 69 None 8 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10144 69 None 8 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
32798 10144 69 None 8 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10144 69 None 8 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
330973 49659 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49659 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
4464266 23472 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
CHEMBL1333735 23472 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
3245442 39796 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
CHEMBL1477013 39796 13 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
330973 49659 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49659 3 None 5 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
221 3465 71 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
3277600 3465 71 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
CHEMBL323356 3465 71 None 15 3 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
2131 3473 69 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
6604009 3473 69 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
CHEMBL10284 3473 69 None -95 4 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
11957729 9374 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL111583 9374 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL1456417 9374 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
990305 19920 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
CHEMBL1302894 19920 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
663874 22282 8 None 6 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
CHEMBL1323851 22282 8 None 6 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
976409 22519 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
CHEMBL1326010 22519 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
11958608 22674 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
CHEMBL1327451 22674 0 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
1280304 23051 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
CHEMBL1330510 23051 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
655127 23454 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
CHEMBL1333565 23454 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
460749 23517 8 None -7 6 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 23517 8 None -7 6 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
2294485 23869 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
CHEMBL1336887 23869 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
3719993 24053 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
CHEMBL1338432 24053 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
712393 24495 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
CHEMBL1342416 24495 12 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
1472225 24712 11 None -3 7 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24712 11 None -3 7 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
660526 24758 8 None 12 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
CHEMBL1344621 24758 8 None 12 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
658229 25148 14 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
CHEMBL1347853 25148 14 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
4110386 25478 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
CHEMBL1350719 25478 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
5899874 26463 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
CHEMBL1360263 26463 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
663277 26768 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
CHEMBL1362909 26768 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
2765288 27542 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
CHEMBL1369322 27542 16 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
2928110 28184 8 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
CHEMBL1373766 28184 8 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
3236129 29053 14 None 31 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
CHEMBL1381093 29053 14 None 31 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
73453 29585 24 None -117 16 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29585 24 None -117 16 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
5714708 30439 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
CHEMBL1392791 30439 4 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
653302 30547 2 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
CHEMBL1393731 30547 2 None 25 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
2086771 31297 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
CHEMBL1401882 31297 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
3492160 31809 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
CHEMBL1406696 31809 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
135449491 33386 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
CHEMBL1419679 33386 1 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
54680929 34155 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
CHEMBL1426103 34155 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
12005819 36742 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
CHEMBL1449816 36742 9 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
3244421 37298 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
CHEMBL1454196 37298 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
645800 37404 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
CHEMBL1455108 37404 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
710950 37729 22 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
CHEMBL1458035 37729 22 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
661708 37885 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
CHEMBL1459372 37885 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
3647020 38059 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL1460803 38059 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
7161174 38742 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
CHEMBL1466394 38742 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
2082741 39391 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
CHEMBL1471830 39391 5 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
54677987 40761 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
CHEMBL1485451 40761 10 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
5739060 40817 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
CHEMBL1485925 40817 14 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
3236790 41342 8 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
CHEMBL1490036 41342 8 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
660206 41398 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
CHEMBL1490456 41398 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
2188092 41805 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
CHEMBL1493478 41805 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
3243693 41969 8 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
CHEMBL1495119 41969 8 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
975392 42441 9 None 1 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
CHEMBL1499411 42441 9 None 1 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
3661786 42505 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
CHEMBL1499998 42505 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
3107134 42833 2 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
CHEMBL1502902 42833 2 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
659306 44185 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
CHEMBL1516678 44185 7 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
686157 44192 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
CHEMBL1516735 44192 15 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
3240692 44357 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
CHEMBL1518405 44357 11 None - 1 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
3236043 44577 9 None 5 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
CHEMBL1520338 44577 9 None 5 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
1355435 45468 11 None 22 2 Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 0 4 3.3 Cc1cn(S(=O)(=O)c2ccc(Br)c3ccccc23)cn1 nan