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Ligand source activities (1 row/activity)

Ligand Receptor Assay information Chemical information
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name
GPCRdb ID #Vendors UniProt IUPHAR Species p-value
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Activity
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Activity
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Activity
Value
Assay Type Assay Description Source Mol
weight
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H don H acc LogP Smiles DOI
23121947 3207 0 NPSR1 NPS receptor Human - = Unclassified
pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>
Guide to Pharmacology 448 5 1 4 3.3 O=C(N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1)NCCN1CCCCC1 18555684
7929 3207 0 NPSR1 NPS receptor Human - = Unclassified
pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>
Guide to Pharmacology 448 5 1 4 3.3 O=C(N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1)NCCN1CCCCC1 18555684
CHEMBL470485 3207 0 NPSR1 NPS receptor Human - = Unclassified
pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>pK<sub>e</sub> value of 6.96 vs. hNPS receptor variant Ile<sup>107</sup>
Guide to Pharmacology 448 5 1 4 3.3 O=C(N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1)NCCN1CCCCC1 18555684
CHEMBL438162 207263 0 NPSR1 NPS receptor Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1195 9 NPSR1 NPS receptor Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1195 9 NPSR1 NPS receptor Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1195 9 NPSR1 NPS receptor Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL437201 207222 0 NPSR1 NPS receptor Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL441576 207401 0 NPSR1 NPS receptor Mouse 9.2 pEC50 = 9.2 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1195 9 NPSR1 NPS receptor Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1195 9 NPSR1 NPS receptor Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1195 9 NPSR1 NPS receptor Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
1491 2631 7 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL1765705 2631 7 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
44123843 1195 9 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
9166 1195 9 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL230333 1195 9 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL430024 207118 0 NPSR1 NPS receptor Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44156964 3049 0 NPSR1 NPS receptor Rat 8.9 pEC50 = 8.9 Binding
Displacement of [3H]quinolinone from rat NPS receptorDisplacement of [3H]quinolinone from rat NPS receptor
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Rat 8.9 pEC50 = 8.9 Binding
Displacement of [3H]quinolinone from rat NPS receptorDisplacement of [3H]quinolinone from rat NPS receptor
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Rat 8.9 pEC50 = 8.9 Binding
Displacement of [3H]quinolinone from rat NPS receptorDisplacement of [3H]quinolinone from rat NPS receptor
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL409981 206306 0 NPSR1 NPS receptor Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267034 204225 0 NPSR1 NPS receptor Mouse 8.8 pEC50 = 8.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(I)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398483 206037 0 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1C)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398524 206038 0 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL390860 205958 0 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL524693 207713 0 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL453962 207479 0 NPSR1 NPS receptor Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL2372117 203711 0 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]1(NC(=O)[C@@H](N)CO)CCc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1195 9 NPSR1 NPS receptor Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
9166 1195 9 NPSR1 NPS receptor Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL230333 1195 9 NPSR1 NPS receptor Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL499957 207529 0 NPSR1 NPS receptor Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL506383 207633 0 NPSR1 NPS receptor Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
5810 1265 0 NPSR1 NPS receptor Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL526355 1265 0 NPSR1 NPS receptor Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL401641 206040 0 NPSR1 NPS receptor Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL525447 207744 0 NPSR1 NPS receptor Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
44156964 3049 0 NPSR1 NPS receptor Rat 5.9 pEC50 = 5.9 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Rat 5.9 pEC50 = 5.9 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Rat 5.9 pEC50 = 5.9 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL437838 207246 0 NPSR1 NPS receptor Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL409555 206281 0 NPSR1 NPS receptor Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL500802 207552 0 NPSR1 NPS receptor Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL396531 206011 0 NPSR1 NPS receptor Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL447434 207453 0 NPSR1 NPS receptor Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL500443 207536 0 NPSR1 NPS receptor Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526551 207786 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL428331 206951 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL267266 204232 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267479 204237 0 NPSR1 NPS receptor Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL439309 207348 0 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1195 9 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
9166 1195 9 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL230333 1195 9 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL525809 207755 0 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL400369 206039 0 NPSR1 NPS receptor Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437199 207221 0 NPSR1 NPS receptor Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437389 207228 0 NPSR1 NPS receptor Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510673 207679 0 NPSR1 NPS receptor Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL230108 202983 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL448242 207456 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN/C(N)=N/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524688 207712 0 NPSR1 NPS receptor Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None C/N=C(/NC)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL526323 207771 0 NPSR1 NPS receptor Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL437764 207244 0 NPSR1 NPS receptor Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL438866 207314 0 NPSR1 NPS receptor Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL505996 207624 0 NPSR1 NPS receptor Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL438115 207262 0 NPSR1 NPS receptor Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL229994 202982 0 NPSR1 NPS receptor Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL507664 207653 0 NPSR1 NPS receptor Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CCC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1021/jm900604g
CHEMBL263801 204104 0 NPSR1 NPS receptor Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL252537 204023 0 NPSR1 NPS receptor Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL411392 206395 0 NPSR1 NPS receptor Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510338 207676 0 NPSR1 NPS receptor Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524654 207706 0 NPSR1 NPS receptor Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL411571 206409 0 NPSR1 NPS receptor Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C1(NC(=O)[C@@H](N)CO)Cc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL503441 207589 0 NPSR1 NPS receptor Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL413849 206604 0 NPSR1 NPS receptor Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1195 9 NPSR1 NPS receptor Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
9166 1195 9 NPSR1 NPS receptor Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL230333 1195 9 NPSR1 NPS receptor Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL505174 207613 0 NPSR1 NPS receptor Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL451444 207470 0 NPSR1 NPS receptor Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL425840 206852 0 NPSR1 NPS receptor Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
5811 1413 0 NPSR1 NPS receptor Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL505657 1413 0 NPSR1 NPS receptor Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL500458 207538 0 NPSR1 NPS receptor Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)c1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526492 207779 0 NPSR1 NPS receptor Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL525398 207739 0 NPSR1 NPS receptor Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL509091 207666 0 NPSR1 NPS receptor Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)[C@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL427638 206871 0 NPSR1 NPS receptor Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL268436 204268 0 NPSR1 NPS receptor Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
44580138 188031 0 NPSR1 NPS receptor Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL525031 188031 0 NPSR1 NPS receptor Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL507881 207655 0 NPSR1 NPS receptor Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL503354 207588 0 NPSR1 NPS receptor Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
44123843 1195 9 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
9166 1195 9 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL230333 1195 9 NPSR1 NPS receptor Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
44634573 2583 0 NPSR1 NPS receptor Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2583 0 NPSR1 NPS receptor Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2583 0 NPSR1 NPS receptor Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2583 0 NPSR1 NPS receptor Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
44156964 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634573 2583 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2583 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2583 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2583 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
44156964 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
11177829 178006 1 NPSR1 NPS receptor Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
CHEMBL469696 178006 1 NPSR1 NPS receptor Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
50925457 18842 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
CHEMBL1290004 18842 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
44156964 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
44156964 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
50925457 18842 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
CHEMBL1290004 18842 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
44634570 43631 0 NPSR1 NPS receptor Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 43631 0 NPSR1 NPS receptor Human 6.0 pIC50 = 6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
49863070 14845 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210411 14845 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44156964 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634512 34635 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL1433323 34635 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL3086835 34635 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
54578636 105795 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 105795 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 105795 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
46202039 63173 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801330 63173 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578634 105785 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 105785 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 105785 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
56676662 63176 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
CHEMBL1801333 63176 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
72735980 105793 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 105793 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 105793 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46907769 55113 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55113 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55113 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
44634561 47631 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 47631 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 47631 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
54578863 105761 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 105761 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 105761 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56676661 63174 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801331 63174 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206934 63163 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801320 63163 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659485 63170 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801327 63170 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56683317 63177 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801334 63177 0 NPSR1 NPS receptor Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
49863016 14840 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210311 14840 0 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
11374217 3380 31 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
76320765 102841 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 102841 0 NPSR1 NPS receptor Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
49862985 14833 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210243 14833 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
44156964 3049 0 NPSR1 NPS receptor Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 minsDisplacement of [125I]NPS from NPS receptor in rat brain superior coliculus after 30 mins
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
46202040 63172 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801329 63172 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669801 63202 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801362 63202 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46907767 55492 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1553073 55492 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1624484 55492 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
56669836 63167 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801324 63167 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
56659483 63160 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801317 63160 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862947 14822 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210178 14822 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634561 47631 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 47631 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 47631 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
44634508 54664 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 54664 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 54664 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL267479 204237 0 NPSR1 NPS receptor Mouse 5.8 pIC50 = 5.8 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
46206599 63154 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63154 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578638 105775 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 105775 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 105775 0 NPSR1 NPS receptor Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
3278392 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
56679981 63165 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801322 63165 0 NPSR1 NPS receptor Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
46208464 14821 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210177 14821 0 NPSR1 NPS receptor Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
44634570 43631 0 NPSR1 NPS receptor Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 43631 0 NPSR1 NPS receptor Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
50925456 18799 0 NPSR1 NPS receptor Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
CHEMBL1289677 18799 0 NPSR1 NPS receptor Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
76320765 102841 0 NPSR1 NPS receptor Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 102841 0 NPSR1 NPS receptor Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
54578634 105785 0 NPSR1 NPS receptor Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 105785 0 NPSR1 NPS receptor Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 105785 0 NPSR1 NPS receptor Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
44634508 54664 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 54664 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 54664 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
72735980 105793 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 105793 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 105793 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202042 63168 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801325 63168 0 NPSR1 NPS receptor Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
49863017 14841 0 NPSR1 NPS receptor Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210312 14841 0 NPSR1 NPS receptor Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578860 105809 0 NPSR1 NPS receptor Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 105809 0 NPSR1 NPS receptor Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 105809 0 NPSR1 NPS receptor Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
44156964 3049 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
54578862 105751 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 105751 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 105751 0 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
56666419 63181 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
CHEMBL1801338 63181 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
11374217 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
44634578 55299 0 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55299 0 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55299 0 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55299 0 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
52944769 18815 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
CHEMBL1289780 18815 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
46205608 63157 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801270 63157 0 NPSR1 NPS receptor Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
11177829 178006 1 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
CHEMBL469696 178006 1 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
8088007 102898 9 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
CHEMBL3086828 102898 9 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
44634521 30211 0 NPSR1 NPS receptor Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1394028 30211 0 NPSR1 NPS receptor Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
3989078 51867 1 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
CHEMBL1589741 51867 1 NPSR1 NPS receptor Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
54578636 105795 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 105795 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 105795 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
54578635 105767 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 105767 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 105767 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
54578637 105797 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 105797 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 105797 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
44634573 2583 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2583 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2583 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2583 0 NPSR1 NPS receptor Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
3278392 20964 1 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
49862984 14832 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210242 14832 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
52942771 18781 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
CHEMBL1289571 18781 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
56666418 63166 0 NPSR1 NPS receptor Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801323 63166 0 NPSR1 NPS receptor Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
44634561 47631 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 47631 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 47631 0 NPSR1 NPS receptor Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
46205607 63158 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801271 63158 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862983 14831 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210241 14831 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
72736545 105796 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 105796 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 105796 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
56676659 63161 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801318 63161 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634514 25911 0 NPSR1 NPS receptor Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
CHEMBL1358647 25911 0 NPSR1 NPS receptor Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
46206933 63156 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801269 63156 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659484 63162 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801319 63162 0 NPSR1 NPS receptor Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46206931 63155 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801268 63155 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206599 63154 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63154 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46189900 63164 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801321 63164 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
155544367 172529 0 NPSR1 NPS receptor Human 5.4 pIC50 = 5.4 Binding
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
CHEMBL4527708 172529 0 NPSR1 NPS receptor Human 5.4 pIC50 = 5.4 Binding
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
44634578 55299 0 NPSR1 NPS receptor Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55299 0 NPSR1 NPS receptor Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55299 0 NPSR1 NPS receptor Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55299 0 NPSR1 NPS receptor Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
49863071 14846 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210412 14846 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
54578861 105810 0 NPSR1 NPS receptor Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 105810 0 NPSR1 NPS receptor Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 105810 0 NPSR1 NPS receptor Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
54578861 105810 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 105810 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 105810 0 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
44634544 30201 0 NPSR1 NPS receptor Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30201 0 NPSR1 NPS receptor Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
11374217 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
46203026 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
5814 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
CHEMBL1801361 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
46203026 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
5814 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
CHEMBL1801361 2929 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
44634573 2583 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2583 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2583 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2583 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
72736373 105752 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 105752 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 105752 0 NPSR1 NPS receptor Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46206598 63200 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801359 63200 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
11374217 3380 31 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
76320765 102841 0 NPSR1 NPS receptor Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 102841 0 NPSR1 NPS receptor Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
11374217 3380 31 NPSR1 NPS receptor Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3380 31 NPSR1 NPS receptor Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3380 31 NPSR1 NPS receptor Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
54578638 105775 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 105775 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 105775 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
56662909 63201 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801360 63201 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
3278392 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL267479 204237 0 NPSR1 NPS receptor Mouse 6.3 pIC50 = 6.3 Functional
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
44156964 3049 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
155557362 173798 0 NPSR1 NPS receptor Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 560 6 1 6 5.4 CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 10.1021/acs.jmedchem.9b01924
CHEMBL4558185 173798 0 NPSR1 NPS receptor Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruitment incubated for 30 mins followed by neuropeptide S addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 560 6 1 6 5.4 CC[C@]12C=C(C(=O)OC)n3c(c(CCNC(=O)c4ccc(Br)cc4)c4ccccc43)[C@H]1N(C#N)CCC2 10.1021/acs.jmedchem.9b01924
46907769 55113 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55113 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55113 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
44156964 3049 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3049 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation countingDisplacement of [125I]Tyr10-NPS from human neuropeptide S receptor expressed in CHO cells after 1.5 hrs by liquid scintillation counting
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634544 30201 0 NPSR1 NPS receptor Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30201 0 NPSR1 NPS receptor Human 4.2 pIC50 = 4.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
56676660 63169 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801326 63169 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578863 105761 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 105761 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 105761 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56679926 62955 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1800088 62955 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578862 105751 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 105751 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 105751 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
49862986 14834 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210244 14834 0 NPSR1 NPS receptor Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578635 105767 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 105767 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 105767 0 NPSR1 NPS receptor Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
46907769 55113 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55113 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55113 0 NPSR1 NPS receptor Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
49862948 14823 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210179 14823 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634508 54664 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 54664 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 54664 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
44634539 39184 0 NPSR1 NPS receptor Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
CHEMBL1474223 39184 0 NPSR1 NPS receptor Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
44156964 3049 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3049 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3049 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
35277770 18800 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
CHEMBL1289678 18800 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
72735980 105793 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 105793 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 105793 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202376 63199 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801358 63199 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
3278392 20964 1 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 20964 1 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 20964 1 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 20964 1 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)Displacement of [125I]Tyr10-NPS from neuropeptide S receptor (unknown origin)
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
72736373 105752 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 105752 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 105752 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46202041 63171 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801328 63171 0 NPSR1 NPS receptor Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
72736545 105796 0 NPSR1 NPS receptor Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 105796 0 NPSR1 NPS receptor Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 105796 0 NPSR1 NPS receptor Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
44634570 43631 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 43631 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced ERK activation after 20 mins by HTRF assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
54578860 105809 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 105809 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 105809 0 NPSR1 NPS receptor Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
56662946 63180 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801337 63180 0 NPSR1 NPS receptor Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
56676652 63159 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801272 63159 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56662945 63179 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801336 63179 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
54578637 105797 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 105797 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 105797 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
46907767 55492 0 NPSR1 NPS receptor Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1553073 55492 0 NPSR1 NPS receptor Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1624484 55492 0 NPSR1 NPS receptor Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
56683318 63178 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
CHEMBL1801335 63178 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
56659486 63175 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801332 63175 0 NPSR1 NPS receptor Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
6893971 71547 6 NPSR1 NPS receptor Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 71547 6 NPSR1 NPS receptor Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
6893971 71547 6 NPSR1 NPS receptor Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 71547 6 NPSR1 NPS receptor Human 9.0 pPotency = 9 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
73453 29213 18 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29213 18 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
73453 29213 18 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29213 18 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
3739574 19159 14 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
CHEMBL1299616 19159 14 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
3242822 21585 6 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
CHEMBL1320806 21585 6 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
795881 24780 29 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
CHEMBL1347786 24780 29 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
645241 24965 1 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
CHEMBL1349430 24965 1 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
654157 26955 2 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
CHEMBL1367658 26955 2 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
44663783 38697 16 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
660794 38697 16 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
CHEMBL1469355 38697 16 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
645086 39765 15 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
CHEMBL1480317 39765 15 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
11958558 44412 0 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
CHEMBL1522550 44412 0 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
741701 47281 11 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
CHEMBL1547978 47281 11 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
664554 47605 7 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
CHEMBL1550682 47605 7 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
2093009 51788 6 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
CHEMBL1589089 51788 6 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
653853 54117 7 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
CHEMBL1610905 54117 7 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
135513617 108161 3 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
CHEMBL3210731 108161 3 NPSR1 NPS receptor Human 8.0 pPotency = 8 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
2930697 20156 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
CHEMBL1307695 20156 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
135521609 22298 3 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
CHEMBL1327226 22298 3 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
2942941 23588 10 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
CHEMBL1337599 23588 10 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
718615 23716 17 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
CHEMBL1338647 23716 17 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
3159744 23866 14 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
CHEMBL1340098 23866 14 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
2767910 29393 14 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
CHEMBL1387210 29393 14 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
3239019 31038 11 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
CHEMBL1402832 31038 11 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
649843 31179 11 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
CHEMBL1404160 31179 11 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
2011082 34357 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
CHEMBL1430872 34357 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
661165 38411 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
CHEMBL1466877 38411 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
5308493 42830 1 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
CHEMBL1506451 42830 1 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
660432 43863 4 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
CHEMBL1517669 43863 4 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
654643 49620 5 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
CHEMBL1570008 49620 5 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
CHEMBL1578105 50482 0 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
1131991 50761 7 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
CHEMBL1580484 50761 7 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
2767561 51568 12 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
CHEMBL1587194 51568 12 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
2973251 53099 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
CHEMBL1602433 53099 8 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
3939641 53992 6 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
CHEMBL1609794 53992 6 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
12005042 54364 2 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
CHEMBL1613111 54364 2 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
1983185 54487 2 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1335567 54487 2 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1616085 54487 2 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
4111848 54850 7 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1387307 54850 7 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1618998 54850 7 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
5994795 108409 4 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
CHEMBL3213983 108409 4 NPSR1 NPS receptor Human 7.0 pPotency = 7 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
32798 9901 56 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 9901 56 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
32798 9901 56 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 9901 56 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
330973 49217 3 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49217 3 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
4464266 23112 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
CHEMBL1333735 23112 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
3245442 39389 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
CHEMBL1477013 39389 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
330973 49217 3 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49217 3 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
221 3275 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
3277600 3275 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
CHEMBL323356 3275 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
2131 3283 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
6604009 3283 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
CHEMBL10284 3283 53 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
11957729 9135 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL111583 9135 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL1456417 9135 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
990305 19565 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
CHEMBL1302894 19565 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
663874 21925 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
CHEMBL1323851 21925 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
976409 22162 15 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
CHEMBL1326010 22162 15 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
11958608 22316 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
CHEMBL1327451 22316 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
1280304 22692 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
CHEMBL1330510 22692 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
655127 23094 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
CHEMBL1333565 23094 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
460749 23157 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 23157 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
2294485 23508 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
CHEMBL1336887 23508 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
3719993 23692 13 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
CHEMBL1338432 23692 13 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
712393 24134 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
CHEMBL1342416 24134 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
1472225 24351 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24351 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
660526 24397 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
CHEMBL1344621 24397 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
658229 24787 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
CHEMBL1347853 24787 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
4110386 25117 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
CHEMBL1350719 25117 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
5899874 26099 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
CHEMBL1360263 26099 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
663277 26404 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
CHEMBL1362909 26404 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
2765288 27176 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
CHEMBL1369322 27176 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
2928110 27814 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
CHEMBL1373766 27814 8 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
3236129 28681 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
CHEMBL1381093 28681 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
73453 29213 18 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29213 18 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
5714708 30066 4 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
CHEMBL1392791 30066 4 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
653302 30171 2 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
CHEMBL1393731 30171 2 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
2086771 30921 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
CHEMBL1401882 30921 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
3492160 31431 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
CHEMBL1406696 31431 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
135449491 33004 1 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
CHEMBL1419679 33004 1 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
54680929 33770 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
CHEMBL1426103 33770 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
12005819 36347 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
CHEMBL1449816 36347 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
3244421 36901 15 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
CHEMBL1454196 36901 15 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
645800 37006 5 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
CHEMBL1455108 37006 5 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
710950 37331 18 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
CHEMBL1458035 37331 18 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
661708 37487 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
CHEMBL1459372 37487 12 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
3647020 37661 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL1460803 37661 11 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
7161174 38340 4 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
CHEMBL1466394 38340 4 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
2082741 38987 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
CHEMBL1471830 38987 6 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
54677987 40353 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
CHEMBL1485451 40353 10 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
CHEMBL1485925 40409 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
3236790 40934 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
CHEMBL1490036 40934 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
CHEMBL1490456 40990 0 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
2188092 41393 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
CHEMBL1493478 41393 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
3243693 41555 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
CHEMBL1495119 41555 7 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
975392 42027 9 NPSR1 NPS receptor Human 6.0 pPotency = 6 Functional
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor