Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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ID		 Reference
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 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
CHEMBL438162 216213 None 0 Mouse Functional pEC50 = 9.2 9.2 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Br)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1273 None 19 Human Functional pEC50 = 9.2 9.2 -2 2
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1273 None 19 Human Functional pEC50 = 9.2 9.2 -2 2
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1273 None 19 Human Functional pEC50 = 9.2 9.2 -2 2
Agonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Ile107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL437201 216171 None 0 Mouse Functional pEC50 = 9.2 9.2 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL441576 216351 None 0 Mouse Functional pEC50 = 9.2 9.2 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1273 None 19 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
9166 1273 None 19 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL230333 1273 None 19 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at human NPSR Asn107 expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
1491 2797 None 16 Mouse Functional pEC50 = 9.0 9.0 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
CHEMBL1765705 2797 None 16 Mouse Functional pEC50 = 9.0 9.0 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 minsAgonist activity at mouse NPSR expressed in HEK293 cells assessed as induction of calcium mobilization after 30 mins
ChEMBL None None None None 10.1021/jm200138r
44123843 1273 None 19 Mouse Functional pEC50 = 9.0 9.0 2 2
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
9166 1273 None 19 Mouse Functional pEC50 = 9.0 9.0 2 2
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL230333 1273 None 19 Mouse Functional pEC50 = 9.0 9.0 2 2
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL430024 216067 None 0 Mouse Functional pEC50 = 9.0 9.0 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL409981 215253 None 0 Mouse Functional pEC50 = 8.9 8.9 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267034 213169 None 0 Mouse Functional pEC50 = 8.8 8.8 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(I)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398483 214984 None 0 Mouse Functional pEC50 = 8.7 8.7 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1C)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL398524 214985 None 0 Mouse Functional pEC50 = 8.7 8.7 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL390860 214905 None 0 Mouse Functional pEC50 = 8.0 8.0 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL524693 218110 None 0 Mouse Functional pEC50 = 8.0 8.0 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL453962 216458 None 0 Mouse Functional pEC50 = 7.0 7.0 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL2372117 212647 None 0 Mouse Functional pEC50 = 8.0 8.0 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]1(NC(=O)[C@@H](N)CO)CCc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1273 None 19 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
9166 1273 None 19 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL230333 1273 None 19 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL499957 216593 None 0 Mouse Functional pEC50 = 5.9 5.9 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL506383 216697 None 0 Mouse Functional pEC50 = 6.9 6.9 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
5810 1356 None 0 Mouse Functional pEC50 = 7.9 7.9 3 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL526355 1356 None 0 Mouse Functional pEC50 = 7.9 7.9 3 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL401641 214987 None 0 Mouse Functional pEC50 = 6.9 6.9 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL525447 218141 None 0 Mouse Functional pEC50 = 6.9 6.9 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL437838 216196 None 0 Mouse Functional pEC50 = 7.8 7.8 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL409555 215228 None 0 Mouse Functional pEC50 = 7.8 7.8 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL500802 216616 None 0 Mouse Functional pEC50 = 5.8 5.8 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL396531 214958 None 0 Mouse Functional pEC50 = 6.8 6.8 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL447434 216412 None 0 Mouse Functional pEC50 = 6.8 6.8 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL500443 216600 None 0 Mouse Functional pEC50 = 5.8 5.8 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526551 218183 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL428331 215900 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL267266 213176 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL267479 213181 None 0 Mouse Functional pEC50 = 6.7 6.7 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL439309 216298 None 0 Mouse Functional pEC50 = 8.7 8.7 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1273 None 19 Mouse Functional pEC50 = 8.7 8.7 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
9166 1273 None 19 Mouse Functional pEC50 = 8.7 8.7 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL230333 1273 None 19 Mouse Functional pEC50 = 8.7 8.7 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL525809 218152 None 0 Mouse Functional pEC50 = 8.7 8.7 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL400369 214986 None 0 Mouse Functional pEC50 = 8.7 8.7 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437199 216170 None 0 Mouse Functional pEC50 = 8.6 8.6 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
CHEMBL437389 216177 None 0 Mouse Functional pEC50 = 8.6 8.6 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510673 218076 None 0 Mouse Functional pEC50 = 6.7 6.7 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL230108 211919 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL448242 216416 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN/C(N)=N/[N+](=O)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524688 218109 None 0 Mouse Functional pEC50 = 7.7 7.7 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None C/N=C(/NC)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL526323 218168 None 0 Mouse Functional pEC50 = 6.6 6.6 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL437764 216194 None 0 Mouse Functional pEC50 = 7.6 7.6 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL438866 216264 None 0 Mouse Functional pEC50 = 7.6 7.6 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL505996 216688 None 0 Mouse Functional pEC50 = 6.6 6.6 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL438115 216212 None 0 Mouse Functional pEC50 = 7.6 7.6 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL229994 211918 None 0 Mouse Functional pEC50 = 7.6 7.6 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL507664 216943 None 0 Mouse Functional pEC50 = 5.6 5.6 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CCC[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1021/jm900604g
CHEMBL263801 213048 None 0 Mouse Functional pEC50 = 7.6 7.6 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
CHEMBL252537 212967 None 0 Mouse Functional pEC50 = 8.5 8.5 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL411392 215342 None 0 Mouse Functional pEC50 = 8.4 8.4 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL510338 218073 None 0 Mouse Functional pEC50 = 7.5 7.5 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL524654 218103 None 0 Mouse Functional pEC50 = 7.5 7.5 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL411571 215356 None 0 Mouse Functional pEC50 = 7.5 7.5 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C1(NC(=O)[C@@H](N)CO)Cc2ccccc2C1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL503441 216653 None 0 Mouse Functional pEC50 = 6.4 6.4 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL413849 215552 None 0 Mouse Functional pEC50 = 8.4 8.4 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
44123843 1273 None 19 Mouse Functional pEC50 = 8.3 8.3 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
9166 1273 None 19 Mouse Functional pEC50 = 8.3 8.3 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL230333 1273 None 19 Mouse Functional pEC50 = 8.3 8.3 2 2
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm900604g
CHEMBL505174 216677 None 0 Mouse Functional pEC50 = 6.3 6.3 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C 10.1016/j.bmc.2008.08.073
CHEMBL451444 216432 None 0 Mouse Functional pEC50 = 6.3 6.3 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
CHEMBL425840 215801 None 0 Mouse Functional pEC50 = 8.2 8.2 - 1
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
5811 1512 None 0 Mouse Functional pEC50 = 7.2 7.2 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL505657 1512 None 0 Mouse Functional pEC50 = 7.2 7.2 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL500458 216602 None 0 Mouse Functional pEC50 = 6.2 6.2 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)c1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL526492 218176 None 0 Mouse Functional pEC50 = 7.2 7.2 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm8012294
CHEMBL525398 218136 None 0 Mouse Functional pEC50 = 6.1 6.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL509091 217774 None 0 Mouse Functional pEC50 = 6.1 6.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)[C@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O 10.1021/jm900604g
CHEMBL427638 215820 None 0 Mouse Functional pEC50 = 8.1 8.1 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm701204n
CHEMBL268436 213212 None 0 Mouse Functional pEC50 = 8.1 8.1 - 1
Agonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilizationAgonist activity at mouse recombinant NPS receptor expressed in HEK293 cells assessed as intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm701204n
44580138 193474 None 0 Mouse Functional pEC50 = 7.1 7.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL525031 193474 None 0 Mouse Functional pEC50 = 7.1 7.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL 2254 78 35 34 -13.2 CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1016/j.bmc.2008.08.073
CHEMBL507881 217075 None 0 Mouse Functional pEC50 = 7.1 7.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assayAgonist activity at mouse NPSR expressed in HEK293 cells by calcium mobilization assay
ChEMBL None None None None 10.1021/jm8012294
CHEMBL503354 216652 None 0 Mouse Functional pEC50 = 6.1 6.1 - 1
Agonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPRAgonist activity at mouse NPSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by FLIPR
ChEMBL None None None None 10.1016/j.bmc.2008.08.073
44123843 1273 None 19 Mouse Functional pEC50 = 8.0 8.0 2 2
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
9166 1273 None 19 Mouse Functional pEC50 = 8.0 8.0 2 2
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
CHEMBL230333 1273 None 19 Mouse Functional pEC50 = 8.0 8.0 2 2
Agonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at mouse recombinant NPSR expressed in HEK293 cells assessed as calcium mobilization
ChEMBL None None None None 10.1021/jm0706822
44634573 2748 None 1 Human Functional pIC50 = 9.0 9.0 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2748 None 1 Human Functional pIC50 = 9.0 9.0 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2748 None 1 Human Functional pIC50 = 9.0 9.0 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2748 None 1 Human Functional pIC50 = 9.0 9.0 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
44156964 3247 None 0 Human Functional pIC50 = 8.9 8.9 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3247 None 0 Human Functional pIC50 = 8.9 8.9 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 8.9 8.9 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
11177829 178975 None 3 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
CHEMBL469696 178975 None 3 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1016/j.bmcl.2010.10.067
50925457 19232 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
CHEMBL1290004 19232 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1016/j.bmcl.2010.10.067
44156964 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
44156964 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 8 8.0 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
50925457 19232 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
CHEMBL1290004 19232 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 385 3 0 3 4.4 O=C(c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O)N1CCCCC1 10.1021/jm400904m
44634570 44096 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 44096 None 0 Human Functional pIC50 = 6 6.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
49863070 15204 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210411 15204 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 481 9 0 5 4.7 CCC(CC)(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634512 35063 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL1433323 35063 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
CHEMBL3086835 35063 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 7 0 2 4.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCc1ccccc1 10.1021/jm400904m
54578636 106571 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106571 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106571 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
46202039 63749 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801330 63749 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 353 3 0 3 5.5 N#Cc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578634 106561 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106561 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106561 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
56676662 63752 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
CHEMBL1801333 63752 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 502 6 0 4 5.8 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCCC1 10.1016/j.bmcl.2010.04.016
46907769 55637 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55637 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55637 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
44634561 48111 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 48111 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 48111 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
54578863 106537 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 106537 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 106537 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56676661 63750 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801331 63750 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 433 5 0 3 5.9 CCC1CCCCN1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206934 63739 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801320 63739 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 336 3 0 2 5.2 Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659485 63746 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801327 63746 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 364 3 0 3 5.1 Clc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56683317 63753 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801334 63753 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 407 6 0 3 5.3 CCN(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
49863016 15199 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210311 15199 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 483 8 0 4 5.4 CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
76320765 103610 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103610 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
49862985 15192 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210243 15192 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 453 7 0 5 3.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCOCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
46202040 63748 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801329 63748 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 339 3 0 3 5.1 N#Cc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669801 63778 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801362 63778 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3cccnc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56669836 63743 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801324 63743 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
56659483 63736 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801317 63736 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 422 4 0 3 5.6 Brc1ccc(C2(CCC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862947 15181 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210178 15181 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 4.3 CC(CCN1CCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL267479 213181 None 0 Mouse Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 100 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
46206599 63730 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63730 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578638 106551 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106551 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106551 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
3278392 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21359 None 2 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
56679981 63741 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801322 63741 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
46208464 15180 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210177 15180 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 492 6 0 5 4.4 CN1CCN(C2(CN(Cc3cc4ccccc4n(C)c3=O)C(=O)C3CCCCC3)CCCCC2)CC1 10.1016/j.bmcl.2010.04.143
44634570 44096 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1514777 44096 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 348 3 0 3 3.4 Cc1nc2ccccn2c1P(=S)(c1ccccc1)c1ccccc1 10.1021/jm400904m
50925456 19187 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
CHEMBL1289677 19187 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 385 4 1 3 4.6 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)n1 10.1016/j.bmcl.2010.10.067
54578634 106561 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3086823 106561 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
CHEMBL3140209 106561 None 0 Human Functional pIC50 = 8.7 8.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Cl)cc1 10.1021/jm400904m
44634508 55185 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 55185 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 55185 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
72735980 106569 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106569 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106569 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202042 63744 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801325 63744 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)nc1 10.1016/j.bmcl.2010.04.016
49863017 15200 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210312 15200 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 501 8 0 4 5.7 CCC(C)(CCN1CCC(F)(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578860 106585 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106585 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106585 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
44156964 3247 None 0 Human Functional pIC50 = 7.6 7.6 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3247 None 0 Human Functional pIC50 = 7.6 7.6 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 7.6 7.6 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
54578862 106527 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 106527 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 106527 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
56666419 63757 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
CHEMBL1801338 63757 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 538 6 0 4 6.1 CC(C1CCN(C(=O)CCC2(c3ccc(Cl)cc3)c3ccccc3-c3nccn32)CC1)N1CCC(F)(F)C1 10.1016/j.bmcl.2010.04.016
44634578 55823 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55823 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55823 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55823 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
52944769 19204 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
CHEMBL1289780 19204 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 384 4 1 2 5.2 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2010.10.067
46205608 63733 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801270 63733 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 406 3 0 2 6.4 Brc1ccc(C2(CC3CCCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
11177829 178975 None 3 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
CHEMBL469696 178975 None 3 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 427 4 1 3 4.0 O=C(NCc1ccccc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/jm400904m
8088007 103666 None 4 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
CHEMBL3086828 103666 None 4 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 396 4 0 4 3.8 O=C1c2ccccc2C(=O)C1(c1ccccc1)N1CCN(Cc2ccccc2)CC1 10.1021/jm400904m
44634521 30626 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL1394028 30626 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 332 3 0 3 3.3 Cc1nc2ccccn2c1P(=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3597 None 38 Human Functional pIC50 = 7.6 7.6 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3597 None 38 Human Functional pIC50 = 7.6 7.6 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3597 None 38 Human Functional pIC50 = 7.6 7.6 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
3989078 52372 None 2 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
CHEMBL1589741 52372 None 2 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 361 3 0 2 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)c2ccccc2n1C 10.1021/jm400904m
54578636 106571 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3086836 106571 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
CHEMBL3140243 106571 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 495 7 0 3 5.0 COc1cccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)c1 10.1021/jm400904m
54578635 106543 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 106543 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 106543 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
54578637 106573 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106573 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106573 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
49862984 15191 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210242 15191 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 451 7 0 4 5.1 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
52942771 19168 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
CHEMBL1289571 19168 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 374 4 1 3 4.8 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2010.10.067
56666418 63742 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
CHEMBL1801323 63742 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1cccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)c1 10.1016/j.bmcl.2010.04.016
44634561 48111 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL1550914 48111 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
CHEMBL3086833 48111 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 439 5 0 2 4.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1Cc1ccccc1 10.1021/jm400904m
46205607 63734 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801271 63734 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 392 3 0 2 6.0 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
49862983 15190 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210241 15190 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 437 7 0 4 4.7 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
72736545 106572 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106572 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106572 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
56676659 63737 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801318 63737 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 340 3 0 2 5.0 Fc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634514 26313 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
CHEMBL1358647 26313 None 0 Human Functional pIC50 = 4.5 4.5 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 302 3 0 2 3.1 c1ccc(P(c2ccccc2)c2cnc3ccccn23)cc1 10.1021/jm400904m
46206933 63732 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801269 63732 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 401 3 0 3 5.1 Brc1ccc(C2(Cc3cccnc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56659484 63738 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801319 63738 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 356 3 0 2 5.6 Clc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46206931 63731 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801268 63731 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 425 3 0 3 5.5 N#Cc1ccccc1CC1(c2ccc(Br)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
46206599 63730 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801267 63730 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 400 3 0 2 5.7 Brc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
46189900 63740 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801321 63740 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 347 3 0 3 4.8 N#Cc1ccc(C2(Cc3ccccc3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
44634578 55823 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1476356 55823 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL1622833 55823 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
CHEMBL3086829 55823 None 0 Human Functional pIC50 = 4.4 4.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 349 3 0 2 2.5 C[n+]1cc(P(=S)(c2ccccc2)c2ccccc2)n2ccccc21 10.1021/jm400904m
49863071 15205 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
CHEMBL1210412 15205 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 493 7 0 5 4.9 Cn1c(=O)c(CN(C(=O)C2CCCCC2)C2(CCN3CCOCC3)CCCCC2)cc2ccccc21 10.1016/j.bmcl.2010.04.143
54578861 106586 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106586 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106586 None 0 Human Functional pIC50 = 8.4 8.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
54578861 106586 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3086824 106586 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
CHEMBL3140269 106586 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 533 6 0 2 6.0 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(C(F)(F)F)cc1 10.1021/jm400904m
44634544 30616 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30616 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
11374217 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
11374217 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3597 None 38 Human Functional pIC50 = 6.4 6.4 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
46203026 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
5814 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
CHEMBL1801361 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1016/j.bmcl.2010.04.016
46203026 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
5814 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
CHEMBL1801361 3119 None 1 Human Functional pIC50 = 7.4 7.4 128 2
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 423 7 0 4 5.0 CCN(C(=O)CCC1(c2ccc(cc2)Cl)n2ccnc2c2c1c(OC)ccc2)CC 10.1021/jm400904m
44634573 2748 None 1 Human Functional pIC50 = 7.4 7.4 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
9168 2748 None 1 Human Functional pIC50 = 7.4 7.4 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1474387 2748 None 1 Human Functional pIC50 = 7.4 7.4 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
CHEMBL1622930 2748 None 1 Human Functional pIC50 = 7.4 7.4 67 15
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 465 6 0 2 5.0 Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 10.1021/jm400904m
72736373 106528 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 106528 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 106528 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46206598 63776 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801359 63776 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1cccc2c1C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
76320765 103610 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
CHEMBL3085788 103610 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as cAMP level by cell based assay
ChEMBL 500 6 1 7 4.0 COc1ccc(C2c3c(ccc4ccccc34)OC3N=CN(CCN4CCOCC4)C(=N)C32)cc1OC 10.1021/jm400904m
11374217 3597 None 38 Human Functional pIC50 = 8.3 8.3 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
5813 3597 None 38 Human Functional pIC50 = 8.3 8.3 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
CHEMBL469695 3597 None 38 Human Functional pIC50 = 8.3 8.3 -3 8
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/jm400904m
54578638 106551 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3086825 106551 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
CHEMBL3140174 106551 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(Br)cc1 10.1021/jm400904m
56662909 63777 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801360 63777 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 449 5 0 4 5.5 COc1ccc2c(c1)C(CCC(=O)N1[C@@H](C)CC[C@H]1C)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
3278392 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assayAntagonist activity at neuropeptide S receptor (unknown origin) assessed as intracellular calcium level by cell based assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
3278392 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1314147 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1593439 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL1598051 21359 None 2 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 363 3 0 2 2.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)[n+]2ccccc2n1C 10.1021/jm400904m
CHEMBL267479 213181 None 0 Mouse Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilizationAntagonist activity at mouse NPSR expressed in HEK293 cells assessed as inhibition of 10 nM hNPS-induced calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm0706822
44156964 3247 None 0 Human Functional pIC50 = 7.3 7.3 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
5815 3247 None 0 Human Functional pIC50 = 7.3 7.3 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 7.3 7.3 6 2
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1021/jm400904m
44634544 30616 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
CHEMBL1393909 30616 None 0 Human Functional pIC50 = 4.2 4.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 334 3 0 3 3.1 S=P(c1ccccc1)(c1ccccc1)c1cnc2ccccn12 10.1021/jm400904m
56676660 63745 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801326 63745 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 355 3 0 4 4.3 N#Cc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578863 106537 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3086820 106537 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
CHEMBL3140138 106537 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 515 6 0 2 6.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc2ccccc2c1 10.1021/jm400904m
56679926 63529 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1800088 63529 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 348 3 0 3 4.6 Fc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
54578862 106527 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3086826 106527 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
CHEMBL3140102 106527 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 543 6 0 2 5.8 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Br)c1 10.1021/jm400904m
49862986 15193 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210244 15193 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 465 8 0 4 5.5 CCC(C)(CCN1CCCCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
54578635 106543 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3086821 106543 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
CHEMBL3140149 106543 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 483 6 0 2 5.1 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)cc1 10.1021/jm400904m
46907769 55637 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1472563 55637 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
CHEMBL1621293 55637 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 495 9 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCCc1ccccc1 10.1021/jm400904m
49862948 15182 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
CHEMBL1210179 15182 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 439 7 0 5 3.6 CC(CCN1CCOCC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1 10.1016/j.bmcl.2010.04.143
44634508 55185 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1315807 55185 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
CHEMBL1617408 55185 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 453 6 0 2 4.5 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCc1ccccc1 10.1021/jm400904m
44634539 39630 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
CHEMBL1474223 39630 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 347 3 0 2 3.9 Cn1cc(P(=S)(c2ccccc2)c2ccccc2)c2ccccc21 10.1021/jm400904m
44156964 3247 None 0 Human Functional pIC50 = 6.1 6.1 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
5815 3247 None 0 Human Functional pIC50 = 6.1 6.1 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
CHEMBL1210313 3247 None 0 Human Functional pIC50 = 6.1 6.1 6 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 467 8 0 5 4.3 CCC(N(C(=O)C1CCCCC1)Cc1cc2ccccc2n(c1=O)C)(CCN1CCOCC1)C 10.1016/j.bmcl.2010.04.143
35277770 19188 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
CHEMBL1289678 19188 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assayAntagonist activity at human recombinant GPR154 receptor expressed in HEK293 cells assessed as inhibition of neuropeptide S-induced increase of intracellular calcium level by FLIPR assay
ChEMBL 390 4 1 3 5.3 O=C(Nc1ccccc1C(=O)N1CCCCC1)c1ccc(-c2ccccc2)s1 10.1016/j.bmcl.2010.10.067
72735980 106569 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3086834 106569 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
CHEMBL3140236 106569 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 467 5 0 3 4.2 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C(=O)Cc1ccccc1 10.1021/jm400904m
46202376 63775 None 0 Human Functional pIC50 = 7.1 7.1 85 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
CHEMBL1801358 63775 None 0 Human Functional pIC50 = 7.1 7.1 85 2
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 394 4 0 4 5.1 COc1ccc2c(c1)C(CC1CCOCC1)(c1ccc(Cl)cc1)n1ccnc1-2 10.1016/j.bmcl.2010.04.016
72736373 106528 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3086827 106528 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
CHEMBL3140103 106528 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 561 6 0 2 5.9 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccc(F)c(Br)c1 10.1021/jm400904m
46202041 63747 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
CHEMBL1801328 63747 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 3 0 3 5.4 Brc1ccc(C2(CC3CCCC3)c3ccccc3-c3nccn32)cn1 10.1016/j.bmcl.2010.04.016
72736545 106572 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3086822 106572 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
CHEMBL3140244 106572 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 479 6 0 2 5.3 Cc1ccc(/C=C/C[n+]2c(C)c(P(=S)(c3ccccc3)c3ccccc3)n3ccccc32)cc1 10.1021/jm400904m
54578860 106585 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3086838 106585 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
CHEMBL3140268 106585 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as inhibition of NPS-induced calcium mobilization after 10 mins by fluorescence assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1cccc(Cl)c1 10.1021/jm400904m
56662946 63756 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801337 63756 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 393 6 0 3 5.0 CCN(CC)C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
56676652 63735 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
CHEMBL1801272 63735 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 408 3 0 3 5.2 Brc1ccc(C2(CC3CCOCC3)c3ccccc3-c3nccn32)cc1 10.1016/j.bmcl.2010.04.016
56662945 63755 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
CHEMBL1801336 63755 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 419 4 0 3 5.5 C[C@H]1CC[C@@H](C)N1C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21 10.1016/j.bmcl.2010.04.016
54578637 106573 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3086837 106573 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
CHEMBL3140246 106573 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 499 6 0 2 5.7 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1C/C=C/c1ccccc1Cl 10.1021/jm400904m
46907767 56018 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1553073 56018 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
CHEMBL1624484 56018 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assayAntagonist activity at neuropeptide S receptor (unknown origin) expressed in CHO cells assessed as cAMP level after 30 mins by phosphate-buffered saline assay
ChEMBL 481 8 0 2 5.3 Cc1c(P(=S)(c2ccccc2)c2ccccc2)n2ccccc2[n+]1CCCCc1ccccc1 10.1021/jm400904m
56683318 63754 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
CHEMBL1801335 63754 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 431 4 0 3 5.6 O=C(CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)N1C2CCCC1CC2 10.1016/j.bmcl.2010.04.016
56659486 63751 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
CHEMBL1801332 63751 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
ChEMBL 421 6 0 3 5.7 CC(C)N(C(=O)CCC1(c2ccc(Cl)cc2)c2ccccc2-c2nccn21)C(C)C 10.1016/j.bmcl.2010.04.016
11374217 3597 None 38 Mouse Functional pKd = 7.8 7.8 3 8
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
5813 3597 None 38 Mouse Functional pKd = 7.8 7.8 3 8
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL469695 3597 None 38 Mouse Functional pKd = 7.8 7.8 3 8
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL 445 4 1 3 4.1 Fc1ccc(cc1)CNC(=O)N1CCN2C(C1)C(OC2=O)(c1ccccc1)c1ccccc1 10.1021/acs.jmedchem.0c02223
CHEMBL5077621 216996 None 0 Mouse Functional pKd = 7.6 7.6 - 0
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None O=C(NCc1ccc(F)cc1)N1C[C@H](c2ccccc2)N2C(=O)OC(c3ccccc3)(c3ccccc3)[C@H]2C1 10.1021/acs.jmedchem.0c02223
CHEMBL5091859 217820 None 0 Mouse Functional pKd = 7.1 7.1 - 0
Antagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assayAntagonist activity at mouse Neuropeptide S receptor expressed in HEK293 cells assessed as rightward shift in NPS concentration response curve of intracellular calcium mobilization without affecting maximal effect at 100 nM treated for 24 mins prior to NPS addition measured immediately by Fluo-4AM dye based FLIPR assay
ChEMBL None None None N=C(NCc1ccc(F)cc1)N1CCN2C(=O)OC(c3ccccc3)(c3ccccc3)C2C1 10.1021/acs.jmedchem.0c02223
6893971 72149 None 5 Human Functional pPotency = 9 9.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 72149 None 5 Human Functional pPotency = 9 9.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
6893971 72149 None 5 Human Functional pPotency = 9 9.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
CHEMBL1978331 72149 None 5 Human Functional pPotency = 9 9.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 270 4 1 5 2.3 COc1ccc(/C=N/NC(=S)SC)cc1OC nan
73453 29624 None 14 Human Functional pPotency = 8 8.0 -117 16
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29624 None 14 Human Functional pPotency = 8 8.0 -117 16
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
73453 29624 None 14 Human Functional pPotency = 8 8.0 -117 16
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29624 None 14 Human Functional pPotency = 8 8.0 -117 16
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
3739574 19553 None 15 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
CHEMBL1299616 19553 None 15 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 0 4 4.7 Cc1cc(C)n(Cc2ccc(Cl)cc2Cl)c(=O)c1S(=O)(=O)c1ccccc1 nan
3242822 21980 None 2 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
CHEMBL1320806 21980 None 2 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 5 3.0 CCOC(=O)c1ccc(NS(=O)(=O)c2ccc3c(c2)CCCN3C(C)=O)cc1 nan
795881 25181 None 30 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
CHEMBL1347786 25181 None 30 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 226 5 1 2 2.9 CCc1ccc(CNCc2cccnc2)cc1 nan
645241 25366 None 0 Human Functional pPotency = 8 8.0 1584 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
CHEMBL1349430 25366 None 0 Human Functional pPotency = 8 8.0 1584 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 3 5 4.8 COc1cc(NC(=O)c2ccco2)c(OC)cc1NC(=O)Nc1ccc(Cl)cc1 nan
654157 27360 None 0 Human Functional pPotency = 8 8.0 1995 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
CHEMBL1367658 27360 None 0 Human Functional pPotency = 8 8.0 1995 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 1 0 3 3.8 Cn1c(C(=O)N2CCCc3ccccc32)cc2sccc21 nan
44663783 39142 None 12 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
660794 39142 None 12 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
CHEMBL1469355 39142 None 12 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 4 3 4 4.9 CCN(CC)c1ccc(C2Nc3cccc4cccc(c34)N2)c(O)c1 nan
645086 40215 None 11 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
CHEMBL1480317 40215 None 11 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 2 3 2.0 O=C(O)CCNS(=O)(=O)c1ccc2c(c1)Cc1ccccc1-2 nan
11958558 44880 None 0 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
CHEMBL1522550 44880 None 0 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 3 4 5.0 O=C(Cc1ccc(Nc2nc3cc(Br)ccc3[nH]2)cc1)NCCc1cccs1 nan
741701 47761 None 7 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
CHEMBL1547978 47761 None 7 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 6 3.4 CCOC(=O)c1cnn(-c2ccccc2)c1NC(=O)c1cccs1 nan
664554 48085 None 5 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
CHEMBL1550682 48085 None 5 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 2 2 8 1.9 COc1ccc(C2NC3=C(CCC3)C3(C#N)C4(N=C(N)C23C#N)OCCO4)cc1 nan
2093009 52293 None 3 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
CHEMBL1589089 52293 None 3 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 1 5 3.4 Cc1ccc(NC(=O)c2cc(S(=O)(=O)N3CCCCC3)ccc2N2CCOCC2)cc1F nan
653853 54635 None 3 Human Functional pPotency = 8 8.0 501 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
CHEMBL1610905 54635 None 3 Human Functional pPotency = 8 8.0 501 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 287 5 1 5 1.7 COc1ccc(CNC(=O)c2cnc(C)cn2)c(OC)c1 nan
135513617 108943 None 2 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
CHEMBL3210731 108943 None 2 Human Functional pPotency = 8 8.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 159 3 2 5 0.2 CC(=N\O)/C(CN(C)C)=N/O nan
2930697 20550 None 6 Human Functional pPotency = 7 7.0 316 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
CHEMBL1307695 20550 None 6 Human Functional pPotency = 7 7.0 316 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 0 2 3.5 Cc1cc(N2C(=O)C3CC=CCC3C2=O)cc(C)c1Br nan
135521609 22696 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
CHEMBL1327226 22696 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 4 3.6 N#C/C(=C\c1c[nH]c2ccccc12)c1nnc2n1CCCCC2 nan
2942941 23989 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
CHEMBL1337599 23989 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 6 1 6 3.6 O=C(c1ccccc1)N1CCN(c2ccc([N+](=O)[O-])c(NCc3cccnc3)c2)CC1 nan
718615 24117 None 13 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
CHEMBL1338647 24117 None 13 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 1 4 3.9 CCCC(=O)Nc1cc(-c2nc3ncccc3o2)ccc1C nan
3159744 24267 None 9 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
CHEMBL1340098 24267 None 9 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 1 6 3.1 CCC1CCCCN1CC(O)Cn1c2ccccc2n2c(=O)cc(C)c(C#N)c12 nan
2767910 29805 None 12 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
CHEMBL1387210 29805 None 12 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 3 4.9 Cc1ccc(Oc2ncc(-c3ccc(Cl)cc3)cn2)cc1 nan
3239019 31452 None 9 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
CHEMBL1402832 31452 None 9 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 8 2.8 CCOC(=O)N1CCN(C(=O)CSCC(=O)Nc2nc(-c3ccc(OC)cc3)cs2)CC1 nan
649843 31593 None 8 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
CHEMBL1404160 31593 None 8 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 236 1 1 3 0.9 CN1CCN(CC#CC2(O)CCCCC2)CC1 nan
2011082 34782 None 5 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
CHEMBL1430872 34782 None 5 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 2 2 6.1 Cc1cccc(NC(=O)Nc2cccc(Oc3c(F)c(F)c(F)c(F)c3F)c2)c1 nan
661165 38854 None 5 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
CHEMBL1466877 38854 None 5 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 5 0 6 3.5 CCN(CC)C(=O)C1CCN(c2ncnc3c2cnn3-c2ccc(C)cc2C)CC1 nan
5308493 43291 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
CHEMBL1506451 43291 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 6 1 6 5.2 Cc1oc(-c2cccc(Cl)c2)nc1CN1CCCC(C(=O)NC(C)c2ccc3c(c2)OCCO3)C1 nan
660432 44329 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
CHEMBL1517669 44329 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 5 3.9 COc1cc2nc(-c3ccccc3)nc(N3CCCC3)c2cc1OC nan
654643 50110 None 4 Human Functional pPotency = 7 7.0 199 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
CHEMBL1570008 50110 None 4 Human Functional pPotency = 7 7.0 199 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 2 4 5.4 Cc1ccc(C)c2nc(O)c(CN(Cc3ccco3)C(=O)Nc3ccccc3)cc12 nan
3477545 50978 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
CHEMBL1578105 50978 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 10 2 5 1.7 CCN(CC)CCCN/C=C1\C(=O)NC(=O)N(CCc2ccc(F)cc2)C1=O nan
1131991 51258 None 4 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
CHEMBL1580484 51258 None 4 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 6 1 8 3.0 CCc1nnc(NC(=O)CSc2nnc(C)n2-c2ccc(C)cc2)s1 nan
2767561 52071 None 11 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
CHEMBL1587194 52071 None 11 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 2 8 -0.1 COc1ccc(CCN2C(=O)C3C4CC(C5C(C(=O)NN)=NOC45)C3C2=O)cc1OC nan
2973251 53609 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
CHEMBL1602433 53609 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 3 4 2.8 O=C(O)c1cccc(NC(=O)c2cccc(NC(=O)C3CCCO3)c2)c1 nan
3939641 54510 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
CHEMBL1609794 54510 None 2 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 8 2 7 3.0 CCCCN1C(=O)Cc2c1nc(N)c1c(N)nc(N(CCC)CCC)c(C#N)c21 nan
12005042 54882 None 1 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
CHEMBL1613111 54882 None 1 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 7 1 3 4.7 CCc1ccccc1NC(=O)CC(c1ccc(OC)cc1)n1cccc1 nan
1983185 55007 None 0 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1335567 55007 None 0 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
CHEMBL1616085 55007 None 0 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 207 0 2 6 -1.3 NNC1=N[C@H]2CS(=O)(=O)C[C@H]2S1 nan
4111848 55372 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1387307 55372 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
CHEMBL1618998 55372 None 6 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 5 0 6 4.8 c1coc(CN(Cc2ccco2)c2ncnc3c2oc2ccccc23)c1 nan
5994795 109191 None 3 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
CHEMBL3213983 109191 None 3 Human Functional pPotency = 7 7.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 7 1 7 4.1 COc1cc(/C(C)=N/NC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc(OC)c1OC nan
32798 10178 None 52 Human Functional pPotency = 6 6.0 8 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10178 None 52 Human Functional pPotency = 6 6.0 8 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
32798 10178 None 52 Human Functional pPotency = 6 6.0 8 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
CHEMBL1159650 10178 None 52 Human Functional pPotency = 6 6.0 8 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 466 4 1 5 4.1 CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C nan
330973 49703 None 0 Human Functional pPotency = 6 6.0 5 4
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49703 None 0 Human Functional pPotency = 6 6.0 5 4
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
4464266 23512 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
CHEMBL1333735 23512 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 325 1 1 4 4.5 Nc1ncnc2c1C(c1ccccc1)c1c(ccc3ccccc13)O2 nan
3245442 39839 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
CHEMBL1477013 39839 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 467 7 1 7 5.0 CCOC(=O)C1CCN(C(c2cccnc2)c2c(NC(=O)c3ccco3)sc(C)c2C)CC1 nan
330973 49703 None 0 Human Functional pPotency = 6 6.0 5 4
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
CHEMBL1566610 49703 None 0 Human Functional pPotency = 6 6.0 5 4
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 592 4 0 10 3.0 C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 nan
1024 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
162639143 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
5284373 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
760 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
CHEMBL160 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
DB00091 1289 None 44 Human Functional pPotency = 6 6.0 -16 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL None None None None nan
221 3491 None 49 Human Functional pPotency = 6 6.0 15 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
3277600 3491 None 49 Human Functional pPotency = 6 6.0 15 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
CHEMBL323356 3491 None 49 Human Functional pPotency = 6 6.0 15 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 286 2 2 4 3.6 O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C nan
2131 3499 None 46 Human Functional pPotency = 6 6.0 -95 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
6604009 3499 None 46 Human Functional pPotency = 6 6.0 -95 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
CHEMBL10284 3499 None 46 Human Functional pPotency = 6 6.0 -95 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 nan
11957729 9408 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL111583 9408 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
CHEMBL1456417 9408 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 2 1 2 3.1 C[N+]1(C)C2CCC1CC(OC(=O)c1c[nH]c3ccccc13)C2 nan
990305 19959 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
CHEMBL1302894 19959 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 532 5 3 6 4.6 N#Cc1c(-c2ccccc2)c(-c2ccccc2)nn(CC(=O)NNC(=O)Nc2ccc(Cl)c(Cl)c2)c1=O nan
663874 22321 None 5 Human Functional pPotency = 6 6.0 6 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
CHEMBL1323851 22321 None 5 Human Functional pPotency = 6 6.0 6 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 4 1 5 2.3 CC(=O)c1c(C(C)=O)c(C)n(NC(=O)c2cccnc2)c1C nan
976409 22559 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
CHEMBL1326010 22559 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 3 1 4 3.7 Cc1ccc(C)c(S(=O)(=O)Nc2ccc3scnc3c2)c1 nan
11958608 22714 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
CHEMBL1327451 22714 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 8 2 7 5.2 C=CCCC(=O)Nc1nc(C)c(-c2csc(Nc3cccc(OC)c3)n2)s1 nan
1280304 23091 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
CHEMBL1330510 23091 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 4 3 6 4.8 O=C(/C=C/c1ccco1)NC(=S)Nc1ccc(O)c(-c2nc3ccccc3s2)c1 nan
655127 23494 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
CHEMBL1333565 23494 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 5 2 7 2.3 Cc1cc(C)n(-c2nc(NC(C)C)nc(NC(C)C)n2)n1 nan
460749 23557 None 5 Human Functional pPotency = 6 6.0 -7 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 23557 None 5 Human Functional pPotency = 6 6.0 -7 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
2294485 23909 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
CHEMBL1336887 23909 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 7 3.9 COc1ccc(-c2csc(NC(=S)NC(=O)/C=C/c3ccco3)n2)cc1OC nan
3719993 24093 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
CHEMBL1338432 24093 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 6 1 8 4.2 COc1ccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
712393 24535 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
CHEMBL1342416 24535 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 1 5 4.3 Oc1ccccc1-c1nnc(COc2ccc(Cl)cc2Cl)o1 nan
1472225 24752 None 9 Human Functional pPotency = 6 6.0 -3 7
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 24752 None 9 Human Functional pPotency = 6 6.0 -3 7
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
660526 24798 None 5 Human Functional pPotency = 6 6.0 12 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
CHEMBL1344621 24798 None 5 Human Functional pPotency = 6 6.0 12 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 6 0 9 1.5 CCOC(=O)Cn1c(=O)c2c(nc(N3CCCCC3)n2Cc2ccccc2)n(C)c1=O nan
658229 25188 None 10 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
CHEMBL1347853 25188 None 10 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 8 2.7 COC(=O)CSc1nc2sc3c(c2c(=O)n1-c1ccccc1)CCN(C)C3 nan
4110386 25518 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
CHEMBL1350719 25518 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 9 2 4 4.6 COc1ccc(CCNC(=O)CC(c2ccccc2)c2cccc(C)c2O)cc1OC nan
5899874 26502 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
CHEMBL1360263 26502 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 5 0 3 3.4 CCCCCN1C=CC=C/C1=C\C=C(C#N)C#N nan
663277 26807 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
CHEMBL1362909 26807 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 1 1 4 2.9 N#Cc1c(N)nc2c(c1-c1ccncc1)CCCCC2 nan
2765288 27581 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
CHEMBL1369322 27581 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 3 4.9 N#Cc1ccc(-c2ccc(F)cc2)nc1Sc1ccccc1 nan
2928110 28223 None 5 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
CHEMBL1373766 28223 None 5 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 5 2.7 CCOC(=O)C1=C(C)OC(N)=C(C#N)C1C1CCCCC1 nan
3236129 29092 None 11 Human Functional pPotency = 6 6.0 31 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
CHEMBL1381093 29092 None 11 Human Functional pPotency = 6 6.0 31 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 4 1 6 3.7 Cc1cc(NC(=O)c2ccc(S(=O)(=O)N3CCCC3)cc2)nc2c1c(=O)oc1ccccc12 nan
73453 29624 None 14 Human Functional pPotency = 6 6.0 -117 16
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 29624 None 14 Human Functional pPotency = 6 6.0 -117 16
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
5714708 30478 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
CHEMBL1392791 30478 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 5 2 5 3.4 COC(=O)c1sc(-c2ccc(Cl)cc2)cc1NC(=O)/C=C/C(=O)O nan
653302 30586 None 0 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
CHEMBL1393731 30586 None 0 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 7 1 5 5.5 CCOc1ccc2nc(O)c(CN(Cc3ccco3)C(=O)c3ccc(Br)cc3)cc2c1 nan
2086771 31335 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
CHEMBL1401882 31335 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 7 1 4 4.0 CC(=O)Nc1ccc(SCC(=O)N(CCC#N)c2ccc(C)cc2)cc1 nan
3492160 31847 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
CHEMBL1406696 31847 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 0 4 5.8 Clc1ccc(CSc2snnc2-c2ccccc2)c(Cl)c1 nan
135449491 33424 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
CHEMBL1419679 33424 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 8 2 9 3.1 CN(C)c1ccc(NC(=O)CSCc2nc(O)c3nnn(Cc4ccc(F)cc4)c3n2)cc1 nan
54680929 34194 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
CHEMBL1426103 34194 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 2 2 6 2.7 Cc1csc(NC(=O)c2c(O)c3cccc4c3n(c2=O)CCC4)n1 nan
12005819 36782 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
CHEMBL1449816 36782 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 0 8 3.9 Cc1cc(C)nc(SCc2cc(=O)c(OC(=O)c3ccc(Br)o3)co2)n1 nan
3244421 37339 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
CHEMBL1454196 37339 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 5 4.0 CCOC(=O)C1=C(c2ccccc2)N(C)C(=O)NC1c1ccc(OC(F)F)c(OC)c1 nan
645800 37445 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
CHEMBL1455108 37445 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 9 1 9 4.2 CCOC(=O)Cn1nnnc1C(C(C)C)N(Cc1cc2c(C)cc(C)cc2nc1O)C1CCCC1 nan
710950 37770 None 16 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
CHEMBL1458035 37770 None 16 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 306 3 0 6 2.0 c1ccc(N2CCN(c3nnnn3-c3ccccc3)CC2)cc1 nan
661708 37926 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
CHEMBL1459372 37926 None 11 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 4 1 8 2.8 Cc1ccc(S(=O)(=O)c2cc3c(=O)n4cccc(C)c4nc3n(CC3CCCO3)c2=N)cc1 nan
3647020 38100 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
CHEMBL1460803 38100 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 8 1 6 3.7 CN(CC(CC(=O)Nc1nncs1)c1ccccc1)S(=O)(=O)c1ccc(Br)cc1 nan
7161174 38783 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
CHEMBL1466394 38783 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 4 1 7 0.2 COc1cccc(NS(=O)(=O)c2c(C)n(C)c(=O)n(C)c2=O)c1 nan
2082741 39432 None 2 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
CHEMBL1471830 39432 None 2 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 1 5 4.1 N#Cc1ccc(NC(=O)c2nc(-c3ccccc3)n(-c3ccccc3)n2)cc1 nan
54677987 40804 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
CHEMBL1485451 40804 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 2 4 4.4 O=C(Cc1c(O)nc2ccccc2c1O)N(Cc1ccccc1)Cc1ccccc1 nan
5739060 40860 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
CHEMBL1485925 40860 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.6 Cc1ccc(C(=O)C2=C(O)C(=O)N(Cc3cccnc3)C2c2ccccn2)cc1 nan
3236790 41385 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
CHEMBL1490036 41385 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 3.0 CCn1cc(C(=O)NCc2ccco2)c(=O)c2cc(S(=O)(=O)N3CCC(C)CC3)ccc21 nan
660206 41441 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
CHEMBL1490456 41441 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 1 4 4.4 COc1ccc(C2C(C#N)=C(C)N=C3C2=C(O)c2ccccc23)cc1 nan
2188092 41849 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
CHEMBL1493478 41849 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 8 0 4 4.4 CCOc1cc(C=O)ccc1OCCSc1ccc(C)cc1 nan
3243693 42013 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
CHEMBL1495119 42013 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 1 3 3.5 Cc1ccc(NC(=O)c2noc3c2CCCCC3)cc1 nan
975392 42485 None 6 Human Functional pPotency = 6 6.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
CHEMBL1499411 42485 None 6 Human Functional pPotency = 6 6.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 1 1 2 4.3 Cc1cc(Br)c2nc3c(c(C(=O)O)c2c1)CCCCC3 nan
3661786 42549 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
CHEMBL1499998 42549 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 5 2 3 3.8 Cc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)Cc1c[nH]c2ccccc12 nan
3107134 42877 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
CHEMBL1502902 42877 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 6 3 7 3.2 COc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(Br)cc3)cc2)nn1 nan
659306 44229 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
CHEMBL1516678 44229 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 2 5 2.8 CCN(CC)CCNc1[nH]cnc2c3cc(OC)ccc3nc1-2 nan
686157 44236 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
CHEMBL1516735 44236 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 4 1 4 2.1 O=C(COc1ccc(Cl)cc1)Nc1ncccn1 nan
3240692 44401 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
CHEMBL1518405 44401 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 2 1 4 4.0 O=C(Nc1cccc(Cl)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
3236043 44621 None 6 Human Functional pPotency = 6 6.0 5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
CHEMBL1520338 44621 None 6 Human Functional pPotency = 6 6.0 5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 8 1 6 2.8 COc1cc(NC(=O)CN2CCN(S(=O)(=O)c3ccc(C(C)C)cc3)CC2)cc(OC)c1 nan
1355435 45512 None 7 Human Functional pPotency = 6 6.0 22 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 0 4 3.3 Cc1cn(S(=O)(=O)c2ccc(Br)c3ccccc23)cn1 nan
CHEMBL1528299 45512 None 7 Human Functional pPotency = 6 6.0 22 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 0 4 3.3 Cc1cn(S(=O)(=O)c2ccc(Br)c3ccccc23)cn1 nan
5291831 46367 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 6 1 8 2.5 CCOC(=O)C(=O)NCc1ccc(/C=C2\C(=O)C(C(=O)OC)=C(C)N2c2ccc(F)cc2)o1 nan
CHEMBL1536243 46367 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 6 1 8 2.5 CCOC(=O)C(=O)NCc1ccc(/C=C2\C(=O)C(C(=O)OC)=C(C)N2c2ccc(F)cc2)o1 nan
659035 46772 None 5 Human Functional pPotency = 6 6.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 6 2 7 1.9 CC(C)Cn1c(N)c(C(=O)NCCN2CCOCC2)c2nc3ccccc3nc21 nan
CHEMBL1539677 46772 None 5 Human Functional pPotency = 6 6.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 6 2 7 1.9 CC(C)Cn1c(N)c(C(=O)NCCN2CCOCC2)c2nc3ccccc3nc21 nan
657993 46917 None 9 Human Functional pPotency = 6 6.0 31 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 282 2 1 4 3.4 COc1ccc(-c2c(C#N)c(S)nc3c2CCC3)cc1 nan
CHEMBL1540912 46917 None 9 Human Functional pPotency = 6 6.0 31 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 282 2 1 4 3.4 COc1ccc(-c2c(C#N)c(S)nc3c2CCC3)cc1 nan
3236020 46991 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 3 1 5 2.6 CCOC(=O)N1CCC(NC(=O)c2ccc3c(c2)N(C)CCS3)CC1 nan
CHEMBL1541466 46991 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 3 1 5 2.6 CCOC(=O)N1CCC(NC(=O)c2ccc3c(c2)N(C)CCS3)CC1 nan
666676 49199 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 300 2 0 6 2.9 COc1ccccc1-c1nn2c(C(F)(F)F)nnc2s1 nan
CHEMBL1562408 49199 None 12 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 300 2 0 6 2.9 COc1ccccc1-c1nn2c(C(F)(F)F)nnc2s1 nan
1221665 49409 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
CHEMBL1564250 49409 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
3236198 50760 None 2 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 4 1 7 3.7 COc1cc(C2C3=C(Nc4ncnn42)c2ccccc2CC3)cc(OC)c1OC nan
CHEMBL1576251 50760 None 2 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 4 1 7 3.7 COc1cc(C2C3=C(Nc4ncnn42)c2ccccc2CC3)cc(OC)c1OC nan
2338011 51149 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 307 6 1 6 0.7 COc1ccccc1CNC(=O)COC(=O)C1=COCCO1 nan
CHEMBL1579480 51149 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 307 6 1 6 0.7 COc1ccccc1CNC(=O)COC(=O)C1=COCCO1 nan
659767 51176 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 257 3 1 5 3.1 Nc1nnc(CSc2ccc(Cl)cc2)s1 nan
CHEMBL1579790 51176 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 257 3 1 5 3.1 Nc1nnc(CSc2ccc(Cl)cc2)s1 nan
662328 52959 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 10 2 6 2.7 COc1ccccc1NC(=O)CCN1CCN(CCC(=O)Nc2ccccc2OC)CC1 nan
CHEMBL1596253 52959 None 7 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 10 2 6 2.7 COc1ccccc1NC(=O)CCN1CCN(CCC(=O)Nc2ccccc2OC)CC1 nan
664487 52977 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 3 0 4 5.5 Cc1cc2oc3c(c(=O)c2cc1C)C(c1cccc(Br)c1)N(Cc1ccco1)C3=O nan
CHEMBL1596484 52977 None 10 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 3 0 4 5.5 Cc1cc2oc3c(c(=O)c2cc1C)C(c1cccc(Br)c1)N(Cc1ccco1)C3=O nan
654560 52986 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 5 1 4 4.2 CCC(=O)N(Cc1cc2cc(OC)ccc2nc1O)c1cccc(C)c1 nan
CHEMBL1596597 52986 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 5 1 4 4.2 CCC(=O)N(Cc1cc2cc(OC)ccc2nc1O)c1cccc(C)c1 nan
3967407 53430 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 2 0 5 3.7 Cc1cccc(N2C(=O)C3C(c4ccccc4)OC4(C(=O)c5ccccc5C4=O)C3C2=O)c1 nan
CHEMBL1600643 53430 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 2 0 5 3.7 Cc1cccc(N2C(=O)C3C(c4ccccc4)OC4(C(=O)c5ccccc5C4=O)C3C2=O)c1 nan
9551566 53741 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 5 1 6 3.4 O=S(=O)(NCc1csc(-c2cccnc2)n1)c1ccc(Cl)s1 nan
CHEMBL1603599 53741 None 0 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 5 1 6 3.4 O=S(=O)(NCc1csc(-c2cccnc2)n1)c1ccc(Cl)s1 nan
2332535 54764 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 283 2 0 3 4.3 O=C(Sc1cccc2cccnc12)c1ccc(F)cc1 nan
CHEMBL1612042 54764 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 283 2 0 3 4.3 O=C(Sc1cccc2cccnc12)c1ccc(F)cc1 nan
135519959 72083 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 265 2 2 4 0.9 Oc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
CHEMBL1976586 72083 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 265 2 2 4 0.9 Oc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 nan
6870079 72350 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 4 2 3 3.1 O=C(N/N=C/C(Br)=C/c1ccccc1)c1[nH]nc2c1CCC2 nan
CHEMBL1984161 72350 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 4 2 3 3.1 O=C(N/N=C/C(Br)=C/c1ccccc1)c1[nH]nc2c1CCC2 nan
9681968 72485 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 3 2 2 3.5 C/C(=N\NC(=S)NC1CCCCC1)c1c(F)cccc1F nan
CHEMBL1988782 72485 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 3 2 2 3.5 C/C(=N\NC(=S)NC1CCCCC1)c1c(F)cccc1F nan
9634351 72908 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 6 0 4 4.7 CCCCn1c(/N=C/c2ccc(N(C)C)cc2)nc2ccccc21 nan
CHEMBL2003445 72908 None 1 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 6 0 4 4.7 CCCCn1c(/N=C/c2ccc(N(C)C)cc2)nc2ccccc21 nan
1066 99974 None 69 Human Functional pPotency = 6 6.0 5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 167 2 2 3 0.5 O=C(O)c1cccnc1C(=O)O nan
CHEMBL286204 99974 None 69 Human Functional pPotency = 6 6.0 5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 167 2 2 3 0.5 O=C(O)c1cccnc1C(=O)O nan
6858755 107701 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 5 1 7 2.4 Nc1nnnn1/N=C/c1ccccc1OCc1ccc(Cl)cc1 nan
CHEMBL3190177 107701 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 5 1 7 2.4 Nc1nnnn1/N=C/c1ccccc1OCc1ccc(Cl)cc1 nan
6870078 107852 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 4 2 3 3.1 O=C(N/N=C/C(Br)=C\c1ccccc1)c1[nH]nc2c1CCC2 nan
CHEMBL3191874 107852 None 3 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 4 2 3 3.1 O=C(N/N=C/C(Br)=C\c1ccccc1)c1[nH]nc2c1CCC2 nan
2882683 108803 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 1 7 3.0 COc1ccc(/N=C2\SC(C(=O)Nc3ccc4c(c3)OCO4)CC(=O)N2C)cc1 nan
CHEMBL3208755 108803 None 8 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 1 7 3.0 COc1ccc(/N=C2\SC(C(=O)Nc3ccc4c(c3)OCO4)CC(=O)N2C)cc1 nan
2091469 108917 None 3 Human Functional pPotency = 6 6.0 7 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 3 0 5 4.9 Cc1onc(-c2ccccc2)c1C(=O)N1CCCS/C1=N\c1ccccc1 nan
CHEMBL3210295 108917 None 3 Human Functional pPotency = 6 6.0 7 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 3 0 5 4.9 Cc1onc(-c2ccccc2)c1C(=O)N1CCCS/C1=N\c1ccccc1 nan
6859247 108955 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 6 0 9 1.3 COc1ccc(/C=N/n2cncn2)cc1Cn1cc([N+](=O)[O-])cn1 nan
CHEMBL3210867 108955 None 4 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 6 0 9 1.3 COc1ccc(/C=N/n2cncn2)cc1Cn1cc([N+](=O)[O-])cn1 nan
6876502 109054 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 7 1 5 3.6 Cc1ccccc1N(CC(=O)N/N=C/c1cc(C)n(-c2ccccc2C)c1C)S(C)(=O)=O nan
CHEMBL3212077 109054 None 6 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 7 1 5 3.6 Cc1ccccc1N(CC(=O)N/N=C/c1cc(C)n(-c2ccccc2C)c1C)S(C)(=O)=O nan
5281847 119038 None 44 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 516 6 5 8 5.4 CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3c(c(C(=O)/C=C/c4ccccc4)c2O)OC(C)(C)C=C3)c1O nan
CHEMBL34241 119038 None 44 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 516 6 5 8 5.4 CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3c(c(C(=O)/C=C/c4ccccc4)c2O)OC(C)(C)C=C3)c1O nan
659038 136033 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 3 1 7 2.7 COc1cc(C2C(C#N)=C(N)Oc3cc(N(C)C)ccc32)cc2c1OCO2 nan
CHEMBL373137 136033 None 9 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 3 1 7 2.7 COc1cc(C2C(C#N)=C(N)Oc3cc(N(C)C)ccc32)cc2c1OCO2 nan
1788522 141778 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 5 2 9 3.2 NC(=S)n1[nH]c(-c2ccc([N+](=O)[O-])cc2)c(/N=N/c2cccc([N+](=O)[O-])c2)c1=O nan
CHEMBL3856090 141778 None 5 Human Functional pPotency = 6 6.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 5 2 9 3.2 NC(=S)n1[nH]c(-c2ccc([N+](=O)[O-])cc2)c(/N=N/c2cccc([N+](=O)[O-])c2)c1=O nan
9687 185441 None 21 Human Functional pPotency = 6 6.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 7 2 11 1.7 CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC nan
CHEMBL1522836 185441 None 21 Human Functional pPotency = 6 6.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 7 2 11 1.7 CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC nan
CHEMBL485980 185441 None 21 Human Functional pPotency = 6 6.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 7 2 11 1.7 CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC nan
3240629 197221 None 0 Human Functional pPotency = 6 6.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 4 1 7 4.6 COc1cccc2sc(Nc3nc(-c4ccccn4)cs3)nc12 nan
CHEMBL546170 197221 None 0 Human Functional pPotency = 6 6.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 4 1 7 4.6 COc1cccc2sc(Nc3nc(-c4ccccn4)cs3)nc12 nan
66541 201042 None 44 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 193 0 0 7 -1.6 Cn1ncnc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL578512 201042 None 44 Human Functional pPotency = 6 6.0 25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 193 0 0 7 -1.6 Cn1ncnc2c(=O)n(C)c(=O)nc1-2 nan
4122 210084 None 71 Human Functional pPotency = 6 6.0 -2 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 3 2 5 3.0 COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1 nan
CHEMBL9514 210084 None 71 Human Functional pPotency = 6 6.0 -2 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 3 2 5 3.0 COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1 nan
107715 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 1461, 1489, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
2198843 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
CHEMBL1302946 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
4177414 25375 None 10 Human Functional pPotency = 5 5.0 25 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 542 6 2 6 6.5 Cc1ccc(C2CC(C(F)F)n3ncc(C(=O)Nc4c(C)nn(Cc5c(F)cccc5Cl)c4C)c3N2)cc1 nan
CHEMBL1349510 25375 None 10 Human Functional pPotency = 5 5.0 25 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 542 6 2 6 6.5 Cc1ccc(C2CC(C(F)F)n3ncc(C(=O)Nc4c(C)nn(Cc5c(F)cccc5Cl)c4C)c3N2)cc1 nan
107715 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
11957499 17263 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 523 7 3 7 5.5 CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O nan
CHEMBL1256686 17263 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 523 7 3 7 5.5 CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O nan
2253255 23446 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 355 4 1 5 3.8 COc1cc(/C=C2\SC(c3ccc(C)cc3)=NC2=O)cc(OC)c1O nan
CHEMBL1333181 23446 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 355 4 1 5 3.8 COc1cc(/C=C2\SC(c3ccc(C)cc3)=NC2=O)cc(OC)c1O nan
5761539 36468 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 356 4 0 4 4.6 CCCN1C(=O)/C(=C\C=C2/C=CN(CC)c3ccccc32)SC1=S nan
CHEMBL1447338 36468 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 356 4 0 4 4.6 CCCN1C(=O)/C(=C\C=C2/C=CN(CC)c3ccccc32)SC1=S nan
1494229 46088 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 457 4 2 7 3.1 CCOC(=O)c1c(-n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C)sc2c1CCCC2 nan
CHEMBL1533351 46088 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 457 4 2 7 3.1 CCOC(=O)c1c(-n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C)sc2c1CCCC2 nan
1221665 49409 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
CHEMBL1564250 49409 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
972880 194472 None 5 Human Functional pPotency = 5 5.0 6 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
CHEMBL528694 194472 None 5 Human Functional pPotency = 5 5.0 6 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
107715 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction, SAR for Probe. (Class of assay: confirmatory) [Related pubchem assays: 1493, 1492, 2566, 2570, 1461, 1489, 2567, 1491, 1464 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
11957499 17263 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 523 7 3 7 5.5 CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O nan
CHEMBL1256686 17263 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 523 7 3 7 5.5 CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O nan
2198843 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
CHEMBL1302946 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
2253255 23446 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 355 4 1 5 3.8 COc1cc(/C=C2\SC(c3ccc(C)cc3)=NC2=O)cc(OC)c1O nan
CHEMBL1333181 23446 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 355 4 1 5 3.8 COc1cc(/C=C2\SC(c3ccc(C)cc3)=NC2=O)cc(OC)c1O nan
4177414 25375 None 10 Human Functional pPotency = 5 5.0 25 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 542 6 2 6 6.5 Cc1ccc(C2CC(C(F)F)n3ncc(C(=O)Nc4c(C)nn(Cc5c(F)cccc5Cl)c4C)c3N2)cc1 nan
CHEMBL1349510 25375 None 10 Human Functional pPotency = 5 5.0 25 2
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 542 6 2 6 6.5 Cc1ccc(C2CC(C(F)F)n3ncc(C(=O)Nc4c(C)nn(Cc5c(F)cccc5Cl)c4C)c3N2)cc1 nan
5761539 36468 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 356 4 0 4 4.6 CCCN1C(=O)/C(=C\C=C2/C=CN(CC)c3ccccc32)SC1=S nan
CHEMBL1447338 36468 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 356 4 0 4 4.6 CCCN1C(=O)/C(=C\C=C2/C=CN(CC)c3ccccc32)SC1=S nan
25109887 40280 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 468 5 1 7 4.1 COc1cccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)c1 nan
CHEMBL1480861 40280 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 468 5 1 7 4.1 COc1cccc(C2c3c(ncn(CCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)c1 nan
1494229 46088 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 457 4 2 7 3.1 CCOC(=O)c1c(-n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C)sc2c1CCCC2 nan
CHEMBL1533351 46088 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 457 4 2 7 3.1 CCOC(=O)c1c(-n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C)sc2c1CCCC2 nan
1221665 49409 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
CHEMBL1564250 49409 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 248 1 2 3 2.8 CN(C)C(=S)N=Nc1[nH]c2ccccc2c1O nan
972880 194472 None 5 Human Functional pPotency = 5 5.0 6 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
CHEMBL528694 194472 None 5 Human Functional pPotency = 5 5.0 6 3
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 268 3 1 5 3.7 Cc1cccnc1Nc1nc(-c2ccccn2)cs1 nan
107715 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 203402 None 16 Human Functional pPotency = 5 5.0 -2691 18
PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) [Related pubchem assays: 1464, 1461 ]
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
1347 162 None 42 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O nan
1864 162 None 42 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O nan
CHEMBL127421 162 None 42 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 4 3 3 1.6 COc1cc2c(CCNC(=O)C)c[nH]c2cc1O nan
2125 379 None 59 Human Functional pPotency = 5 5.0 -467 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 554 4 1 4 5.9 Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 nan
3317 379 None 59 Human Functional pPotency = 5 5.0 -467 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 554 4 1 4 5.9 Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 nan
CHEMBL285932 379 None 59 Human Functional pPotency = 5 5.0 -467 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 554 4 1 4 5.9 Ic1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 nan
176 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157.0 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 398 None 47 Human Functional pPotency = 5 5.0 -66 40
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
37459 746 None 9 Human Functional pPotency = 5 5.0 -22387 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C nan
62 746 None 9 Human Functional pPotency = 5 5.0 -22387 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C nan
CHEMBL8514 746 None 9 Human Functional pPotency = 5 5.0 -22387 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 0 1 2 4.8 O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C nan
2745687 933 None 27 Human Functional pPotency = 5 5.0 -10 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 4 2 6 2.5 COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F nan
9741 933 None 27 Human Functional pPotency = 5 5.0 -10 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 4 2 6 2.5 COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F nan
CHEMBL1708510 933 None 27 Human Functional pPotency = 5 5.0 -10 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 4 2 6 2.5 COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)c1ccc(cc1F)F nan
10531 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
10531.0 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
121 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
888 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL1732 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00320 1420 None 13 Human Functional pPotency = 5 5.0 -11748 29
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
1212 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372.0 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 1662 None 37 Human Functional pPotency = 5 5.0 -7943 35
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
12575 1988 None 24 Human Functional pPotency = 5 5.0 -1202 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 nan
54459 1988 None 24 Human Functional pPotency = 5 5.0 -1202 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 nan
54459.0 1988 None 24 Human Functional pPotency = 5 5.0 -1202 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 nan
CHEMBL10316 1988 None 24 Human Functional pPotency = 5 5.0 -1202 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 nan
DB12551 1988 None 24 Human Functional pPotency = 5 5.0 -1202 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 1 4 0.8 C1CN=C(N1)C2COC3=CC=CC=C3O2 nan
1350 1990 None 0 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 nan
4172142 1990 None 0 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 nan
CHEMBL10009 1990 None 0 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 6 1 3 4.1 CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 nan
1530 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827.0 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
7206 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
CHEMBL534 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
DB00920 2182 None 36 Human Functional pPotency = 5 5.0 -724 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
132846 2238 None 16 Human Functional pPotency = 5 5.0 -12589 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F nan
13432 2238 None 16 Human Functional pPotency = 5 5.0 -12589 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F nan
CHEMBL27006 2238 None 16 Human Functional pPotency = 5 5.0 -12589 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 2 5.7 FC(F)(F)C1=CC(=CC(CO[C@H]2CCCN[C@H]2C3=CC=CC=C3)=C1)C(F)(F)F nan
1599 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
3955 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
3955.0 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
7215 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
CHEMBL841 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
DB00836 2341 None 28 Human Functional pPotency = 5 5.0 -5370 32
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 nan
1909 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
2559 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
4474 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
CHEMBL1484 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
CHEMBL3302409 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
DB00622 2822 None 46 Human Functional pPotency = 5 5.0 -16 13
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 9 1 8 3.7 COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C nan
2028 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
359 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
4634 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
4634.0 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
CHEMBL1231 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
DB01062 2979 None 52 Human Functional pPotency = 5 5.0 -5011 14
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 7 1 4 3.3 CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC nan
209 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
2113 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4748 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4748.0 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
CHEMBL567 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
DB00850 3057 None 57 Human Functional pPotency = 5 5.0 -6918 25
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
2284 3182 None 26 Human Functional pPotency = 5 5.0 -1230 34
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
4926 3182 None 26 Human Functional pPotency = 5 5.0 -1230 34
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
7281 3182 None 26 Human Functional pPotency = 5 5.0 -1230 34
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
CHEMBL564 3182 None 26 Human Functional pPotency = 5 5.0 -1230 34
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
DB00420 3182 None 26 Human Functional pPotency = 5 5.0 -1230 34
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
1432 3602 None 38 Human Functional pPotency = 5 5.0 -35 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 195 2 0 1 3.6 Cc1cccc(n1)/C=C/c1ccccc1 nan
5311432 3602 None 38 Human Functional pPotency = 5 5.0 -35 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 195 2 0 1 3.6 Cc1cccc(n1)/C=C/c1ccccc1 nan
CHEMBL88612 3602 None 38 Human Functional pPotency = 5 5.0 -35 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 195 2 0 1 3.6 Cc1cccc(n1)/C=C/c1ccccc1 nan
2470 3653 None 40 Human Functional pPotency = 5 5.0 -165958 23
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 nan
3300 3653 None 40 Human Functional pPotency = 5 5.0 -165958 23
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 nan
5265 3653 None 40 Human Functional pPotency = 5 5.0 -165958 23
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 nan
99 3653 None 40 Human Functional pPotency = 5 5.0 -165958 23
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 nan
CHEMBL267930 3653 None 40 Human Functional pPotency = 5 5.0 -165958 23
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 nan
1987175 3794 None 27 Human Functional pPotency = 5 5.0 -85 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F nan
9283 3794 None 27 Human Functional pPotency = 5 5.0 -85 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F nan
CHEMBL1372836 3794 None 27 Human Functional pPotency = 5 5.0 -85 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F nan
3260619 4019 None 24 Human Functional pPotency = 5 5.0 -3 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 321 2 0 5 3.7 CC1CCCN(C1)c1ncnc2c1cnn2c1ccc(cc1C)C nan
6227 4019 None 24 Human Functional pPotency = 5 5.0 -3 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 321 2 0 5 3.7 CC1CCCN(C1)c1ncnc2c1cnn2c1ccc(cc1C)C nan
CHEMBL477396 4019 None 24 Human Functional pPotency = 5 5.0 -3 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 321 2 0 5 3.7 CC1CCCN(C1)c1ncnc2c1cnn2c1ccc(cc1C)C nan
5311501 4082 None 8 Human Functional pPotency = 5 5.0 -1819 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 4 0 5 4.6 O=C(c1c(C)n2c3c1cccc3OC[C@H]2CN1CCOCC1)c1cccc2c1cccc2 nan
733 4082 None 8 Human Functional pPotency = 5 5.0 -1819 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 4 0 5 4.6 O=C(c1c(C)n2c3c1cccc3OC[C@H]2CN1CCOCC1)c1cccc2c1cccc2 nan
CHEMBL188 4082 None 8 Human Functional pPotency = 5 5.0 -1819 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 4 0 5 4.6 O=C(c1c(C)n2c3c1cccc3OC[C@H]2CN1CCOCC1)c1cccc2c1cccc2 nan
DB13950 4082 None 8 Human Functional pPotency = 5 5.0 -1819 6
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 4 0 5 4.6 O=C(c1c(C)n2c3c1cccc3OC[C@H]2CN1CCOCC1)c1cccc2c1cccc2 nan
2855 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
3322 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
5717 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
5717.0 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
CHEMBL603 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
DB00549 4132 None 63 Human Functional pPotency = 5 5.0 -5011 12
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C nan
2351 4301 None 35 Human Functional pPotency = 5 5.0 -4 22
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 nan
CHEMBL1008 4301 None 35 Human Functional pPotency = 5 5.0 -4 22
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 nan
CHEMBL1257078 4301 None 35 Human Functional pPotency = 5 5.0 -4 22
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 10 0 3 4.8 CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 nan
11957712 4556 None 2 Human Functional pPotency = 5 5.0 -63 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 356 4 0 3 3.3 CN(C(=O)Cc1ccccc1)[C@@H]1CC[C@]2(CCCO2)C[C@H]1N1CCCC1 nan
CHEMBL102426 4556 None 2 Human Functional pPotency = 5 5.0 -63 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 356 4 0 3 3.3 CN(C(=O)Cc1ccccc1)[C@@H]1CC[C@]2(CCCO2)C[C@H]1N1CCCC1 nan
5994 4643 None 51 Human Functional pPotency = 5 5.0 -3 10
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C nan
CHEMBL103 4643 None 51 Human Functional pPotency = 5 5.0 -3 10
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C nan
3976161 10816 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 8 1 6 3.2 COc1ccc(Cl)cc1NC(=O)COC(=O)C(CC(C)C)N1C(=O)C2CC=CCC2C1=O nan
CHEMBL1172021 10816 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 8 1 6 3.2 COc1ccc(Cl)cc1NC(=O)COC(=O)C(CC(C)C)N1C(=O)C2CC=CCC2C1=O nan
54677920 10843 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 696 9 5 11 5.4 COC1C(OC(=O)c2ccc(C)[nH]2)C(O)C(Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2Cl)OC1(C)C nan
CHEMBL1172192 10843 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 696 9 5 11 5.4 COC1C(OC(=O)c2ccc(C)[nH]2)C(O)C(Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2Cl)OC1(C)C nan
3241232 11012 None 0 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 7 1 6 5.3 c1ccc(-c2oc3ncnc(NCCCn4ccnc4)c3c2-c2ccccc2)cc1 nan
CHEMBL1173823 11012 None 0 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 7 1 6 5.3 c1ccc(-c2oc3ncnc(NCCCn4ccnc4)c3c2-c2ccccc2)cc1 nan
12884 11021 None 53 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 223 1 0 2 2.5 O=C1C(=O)N(c2ccccc2)c2ccccc21 nan
CHEMBL117447 11021 None 53 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 223 1 0 2 2.5 O=C1C(=O)N(c2ccccc2)c2ccccc21 nan
1103407 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
1103408 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
1103409 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
1103410 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
1588442 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
1588443 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
CHEMBL1186487 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
CHEMBL1573754 12493 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 9 2 7 4.4 CCC(/C=C1\Sc2ccc(OC)cc2N1CCO)=C\c1sc2ccc(OC)cc2[n+]1CCO nan
5368 13078 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 10 0 12 4.0 COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccnc(OCc3ncccn3)c2c(=O)n1Cc1ccnc(C)c1 nan
CHEMBL1190161 13078 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 10 0 12 4.0 COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccnc(OCc3ncccn3)c2c(=O)n1Cc1ccnc(C)c1 nan
CHEMBL540294 13078 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 583 10 0 12 4.0 COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccnc(OCc3ncccn3)c2c(=O)n1Cc1ccnc(C)c1 nan
824135 14152 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 249 2 1 0 3.5 Cc1[nH]c2ccccc2c1/C=C/c1cc[n+](C)cc1 nan
824136 14152 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 249 2 1 0 3.5 Cc1[nH]c2ccccc2c1/C=C/c1cc[n+](C)cc1 nan
CHEMBL1198140 14152 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 249 2 1 0 3.5 Cc1[nH]c2ccccc2c1/C=C/c1cc[n+](C)cc1 nan
CHEMBL600360 14152 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 249 2 1 0 3.5 Cc1[nH]c2ccccc2c1/C=C/c1cc[n+](C)cc1 nan
232570 14156 None 5 Human Functional pPotency = 5 5.0 4 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 4 1 3 5.5 CCOc1ccc(Nc2c3ccccc3nc3ccccc23)cc1 nan
CHEMBL1198307 14156 None 5 Human Functional pPotency = 5 5.0 4 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 4 1 3 5.5 CCOc1ccc(Nc2c3ccccc3nc3ccccc23)cc1 nan
2951910 14159 None 31 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 6 2 6 4.0 COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 nan
CHEMBL1198335 14159 None 31 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 6 2 6 4.0 COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 nan
CHEMBL601547 14159 None 31 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 6 2 6 4.0 COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1 nan
169870 14446 None 44 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1200848 14446 None 44 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 6 0 4 6.0 CCCCCC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C nan
3213 16392 None 52 Human Functional pPotency = 5 5.0 2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 246 0 1 1 4.5 Cc1c2ccncc2c(C)c2c1[nH]c1ccccc12 nan
CHEMBL123 16392 None 52 Human Functional pPotency = 5 5.0 2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 246 0 1 1 4.5 Cc1c2ccncc2c(C)c2c1[nH]c1ccccc12 nan
172307 17182 None 22 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 555 7 1 9 4.3 COc1cccc2c1[C@@H]1CN(CCCCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)C[C@@H]1CO2 nan
CHEMBL1256028 17182 None 22 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 555 7 1 9 4.3 COc1cccc2c1[C@@H]1CN(CCCCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)C[C@@H]1CO2 nan
CHEMBL1256183 17182 None 22 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 555 7 1 9 4.3 COc1cccc2c1[C@@H]1CN(CCCCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)C[C@@H]1CO2 nan
10386195 17268 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 7 1 3 5.6 CCCC[C@@]1(C2CCCC2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O nan
CHEMBL1256719 17268 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 7 1 3 5.6 CCCC[C@@]1(C2CCCC2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O nan
5027282 19503 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 1 0 3 4.3 CC1=NN(c2cccc(Cl)c2)C(=O)C12CC(C)=C(C)CS2 nan
CHEMBL1299269 19503 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 1 0 3 4.3 CC1=NN(c2cccc(Cl)c2)C(=O)C12CC(C)=C(C)CS2 nan
655809 19507 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 8 2.8 CC(C)CSc1nc2c(c(=O)[nH]c(=O)n2C)n1CC(O)COc1cccc2ccccc12 nan
CHEMBL1299291 19507 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 8 2.8 CC(C)CSc1nc2c(c(=O)[nH]c(=O)n2C)n1CC(O)COc1cccc2ccccc12 nan
875215 19514 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 0 2 4.4 Cc1cc(/C=C(/C#N)c2cccc(Cl)c2)c(C)n1C nan
CHEMBL1299358 19514 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 270 2 0 2 4.4 Cc1cc(/C=C(/C#N)c2cccc(Cl)c2)c(C)n1C nan
1068792 19548 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 3 0 4 4.6 CC(=O)c1c(N2CCOCC2)nc2ccc(Cl)cc2c1-c1ccccc1 nan
CHEMBL1299564 19548 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 3 0 4 4.6 CC(=O)c1c(N2CCOCC2)nc2ccc(Cl)cc2c1-c1ccccc1 nan
9551208 19551 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 7 1 4 5.1 CCC(C)NC(=O)C1c2ccccc2C(=O)N(c2ccc(OC)cc2)C1c1ccc(OC)cc1 nan
CHEMBL1299595 19551 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 7 1 4 5.1 CCC(C)NC(=O)C1c2ccccc2C(=O)N(c2ccc(OC)cc2)C1c1ccc(OC)cc1 nan
3245671 19556 None 1 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 5 1 5 4.3 Cc1nc2c(C(=O)NCc3ccco3)cnn2c(C)c1Cc1ccc(F)cc1Cl nan
CHEMBL1299672 19556 None 1 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 5 1 5 4.3 Cc1nc2c(C(=O)NCc3ccco3)cnn2c(C)c1Cc1ccc(F)cc1Cl nan
4882749 19557 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 3 4.1 CC(Nc1ccccc1N1CCCCC1)C(=O)N1CCc2ccccc21 nan
CHEMBL1299684 19557 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 3 4.1 CC(Nc1ccccc1N1CCCCC1)C(=O)N1CCc2ccccc21 nan
655882 19570 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 5 1 5 4.4 Cc1ccnc(N2CCC(C(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)n1 nan
CHEMBL1299866 19570 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 5 1 5 4.4 Cc1ccnc(N2CCC(C(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)n1 nan
779355 19572 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 5 3.2 Cn1c(=O)c([N+](=O)[O-])c(Oc2ccccc2)c2ccccc21 nan
CHEMBL1299907 19572 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 0 5 3.2 Cn1c(=O)c([N+](=O)[O-])c(Oc2ccccc2)c2ccccc21 nan
1954975 19587 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 5 1 7 3.8 O=C(Cn1c(=O)n(Cc2ccco2)c(=O)c2c3c(sc21)CCCCC3)Nc1ccccc1 nan
CHEMBL1300008 19587 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 5 1 7 3.8 O=C(Cn1c(=O)n(Cc2ccco2)c(=O)c2c3c(sc21)CCCCC3)Nc1ccccc1 nan
3245657 19603 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 5 1 6 3.8 O=C(Nc1ccc2c(c1)OCO2)C(c1ccc(Cl)cc1)N1CCN(C(=O)c2ccco2)CC1 nan
CHEMBL1300160 19603 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 5 1 6 3.8 O=C(Nc1ccc2c(c1)OCO2)C(c1ccc(Cl)cc1)N1CCN(C(=O)c2ccco2)CC1 nan
5310144 19619 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 5 1 8 2.9 CC(C)c1nc(SCC(=O)Nc2cccc(C(F)(F)F)c2)c2c(=O)n(C)c(=O)n(C)c2n1 nan
CHEMBL1300295 19619 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 5 1 8 2.9 CC(C)c1nc(SCC(=O)Nc2cccc(C(F)(F)F)c2)c2c(=O)n(C)c(=O)n(C)c2n1 nan
3173810 19628 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 0 5 4.8 Cc1ccc(C(c2nnnn2C2CCCCC2)N(C)C2CCCCC2)cc1 nan
CHEMBL1300353 19628 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 0 5 4.8 Cc1ccc(C(c2nnnn2C2CCCCC2)N(C)C2CCCCC2)cc1 nan
16746428 19635 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 0 2 5.4 COc1ccc(Br)cc1[C@H]1[C@H]2C=CC[C@@H](C)[C@@H]2C(=O)N1Cc1ccccc1 nan
CHEMBL1300391 19635 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 0 2 5.4 COc1ccc(Br)cc1[C@H]1[C@H]2C=CC[C@@H](C)[C@@H]2C(=O)N1Cc1ccccc1 nan
663597 19636 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 7 4.1 CC(C)CCn1c(N)c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc21 nan
CHEMBL1300405 19636 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 7 4.1 CC(C)CCn1c(N)c(S(=O)(=O)c2cccs2)c2nc3ccccc3nc21 nan
16195740 19643 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 576 8 1 5 5.2 O=C(C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCc2ccc(CO)cc2)O1)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1300459 19643 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 576 8 1 5 5.2 O=C(C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCc2ccc(CO)cc2)O1)N1CCN(Cc2ccccc2)CC1 nan
737924 19649 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 2 0 2 4.2 CC1=CC(C)(C)N(S(=O)(=O)c2ccc(F)cc2)c2ccccc21 nan
CHEMBL1300500 19649 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 2 0 2 4.2 CC1=CC(C)(C)N(S(=O)(=O)c2ccc(F)cc2)c2ccccc21 nan
3361127 19650 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 565 8 0 5 7.1 [O-][S+](Cc1ccc(Br)cc1)Cc1nnc(SCc2c(Cl)cccc2Cl)n1-c1ccccc1 nan
CHEMBL1300502 19650 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 565 8 0 5 7.1 [O-][S+](Cc1ccc(Br)cc1)Cc1nnc(SCc2c(Cl)cccc2Cl)n1-c1ccccc1 nan
658970 19651 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 4 0 5 3.9 CCCSc1nc(N2CCCC2)c2c(c1C#N)CC(C)(C)OC2 nan
CHEMBL1300512 19651 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 4 0 5 3.9 CCCSc1nc(N2CCCC2)c2c(c1C#N)CC(C)(C)OC2 nan
3240321 19668 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 8 2 6 3.2 COc1ccc(OC)c(NC(=O)c2cc(S(=O)(=O)NCc3ccco3)ccc2F)c1 nan
CHEMBL1300634 19668 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 8 2 6 3.2 COc1ccc(OC)c(NC(=O)c2cc(S(=O)(=O)NCc3ccco3)ccc2F)c1 nan
2815052 19675 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 3 2 3 5.1 Cc1cc(NC(=O)Nc2ccc(Cl)c(Cl)c2)n(-c2ccccc2)n1 nan
CHEMBL1300685 19675 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 3 2 3 5.1 Cc1cc(NC(=O)Nc2ccc(Cl)c(Cl)c2)n(-c2ccccc2)n1 nan
2172598 19688 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 5 3 5 4.6 NS(=O)(=O)c1ccc(NC(S)=Nc2nn(Cc3ccc(Cl)cc3Cl)cc2Cl)cc1 nan
CHEMBL1300738 19688 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 5 3 5 4.6 NS(=O)(=O)c1ccc(NC(S)=Nc2nn(Cc3ccc(Cl)cc3Cl)cc2Cl)cc1 nan
782359 19693 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 6 0 2 5.0 CCN(CC)c1ccc(CN2CC=C(c3ccc(F)cc3)CC2)cc1 nan
CHEMBL1300776 19693 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 6 0 2 5.0 CCN(CC)c1ccc(CN2CC=C(c3ccc(F)cc3)CC2)cc1 nan
4968664 19706 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 519 8 2 6 6.2 COc1cc(C(=O)Nc2nc(-c3cc(C)ccc3C)c(C)s2)ccc1OCC(=O)Nc1ccc(F)cc1 nan
CHEMBL1300883 19706 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 519 8 2 6 6.2 COc1cc(C(=O)Nc2nc(-c3cc(C)ccc3C)c(C)s2)ccc1OCC(=O)Nc1ccc(F)cc1 nan
3244553 19709 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 450 6 2 7 4.6 COc1ccc(-c2cn3c(C)c(C(=O)Nc4cc(NC(C)=O)ccc4OC)sc3n2)cc1 nan
CHEMBL1300912 19709 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 450 6 2 7 4.6 COc1ccc(-c2cn3c(C)c(C(=O)Nc4cc(NC(C)=O)ccc4OC)sc3n2)cc1 nan
15945371 19713 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 1 3 4.3 O=C(CN(Cc1ccccc1)S(=O)(=O)c1cccc(C(F)(F)F)c1)NC1CCCCC1 nan
CHEMBL1300948 19713 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 7 1 3 4.3 O=C(CN(Cc1ccccc1)S(=O)(=O)c1cccc(C(F)(F)F)c1)NC1CCCCC1 nan
943143 19716 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 7 1 5 4.3 CCOC(=O)c1c(NC(=O)CCc2ccc(CC)o2)sc(C)c1C nan
CHEMBL1300958 19716 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 7 1 5 4.3 CCOC(=O)c1c(NC(=O)CCc2ccc(CC)o2)sc(C)c1C nan
2999897 19731 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 4 0 4 3.3 CC1CC(C)CN(S(=O)(=O)c2ccc(C(=O)N3CCN(c4ccccc4)CC3)cc2)C1 nan
CHEMBL1301093 19731 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 4 0 4 3.3 CC1CC(C)CN(S(=O)(=O)c2ccc(C(=O)N3CCN(c4ccccc4)CC3)cc2)C1 nan
665292 19743 None 8 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 8 0 6 3.8 CCCCOC(=O)n1c(SCC(=O)N(CC)CC)nc2ccccc21 nan
CHEMBL1301165 19743 None 8 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 8 0 6 3.8 CCCCOC(=O)n1c(SCC(=O)N(CC)CC)nc2ccccc21 nan
4378046 19750 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 4 2 3 5.0 COc1ccc(NC(=O)NC23CC4(C)CC(C)(CC(C)(C4)C2)C3)cc1OC nan
CHEMBL1301200 19750 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 4 2 3 5.0 COc1ccc(NC(=O)NC23CC4(C)CC(C)(CC(C)(C4)C2)C3)cc1OC nan
661494 19753 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 1 6 5.9 N#CC1=C(SCC(=O)c2ccc(Br)cc2)N=C2CCCC(O)=C2C1c1ccco1 nan
CHEMBL1301213 19753 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 1 6 5.9 N#CC1=C(SCC(=O)c2ccc(Br)cc2)N=C2CCCC(O)=C2C1c1ccco1 nan
5836059 19774 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 543 7 1 10 2.1 CCOC(=O)CC1C(=O)NCCN1c1nc2c(C)cccn2c(=O)c1/C=C1\SC(=S)N(CC(C)C)C1=O nan
CHEMBL1301380 19774 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 543 7 1 10 2.1 CCOC(=O)CC1C(=O)NCCN1c1nc2c(C)cccn2c(=O)c1/C=C1\SC(=S)N(CC(C)C)C1=O nan
648060 19792 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 3 0 6 4.2 CC(C)c1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3 nan
CHEMBL1301505 19792 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 3 0 6 4.2 CC(C)c1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3 nan
1053503 19810 None 1 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 3 0 4 4.4 O=C(c1cc(-c2ccco2)nn1-c1cccc(Cl)c1)N1CCCCC1 nan
CHEMBL1301692 19810 None 1 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 3 0 4 4.4 O=C(c1cc(-c2ccco2)nn1-c1cccc(Cl)c1)N1CCCCC1 nan
3243828 19829 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 0 4 3.5 O=c1c2ccccc2n(Cc2ccc(F)cc2)c(=O)n1C1CCCC1 nan
CHEMBL1301940 19829 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 0 4 3.5 O=c1c2ccccc2n(Cc2ccc(F)cc2)c(=O)n1C1CCCC1 nan
1304874 19830 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 5.7 COc1cc2c(cc1OC)C(c1ccc(-c3cc(Cl)ccc3Cl)o1)=NCC2 nan
CHEMBL1301943 19830 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 5.7 COc1cc2c(cc1OC)C(c1ccc(-c3cc(Cl)ccc3Cl)o1)=NCC2 nan
4584216 19835 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 2 1 3 4.4 S=C(Nc1ccc(Br)cc1)N1CCn2cccc2C1c1cccnc1 nan
CHEMBL1301971 19835 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 2 1 3 4.4 S=C(Nc1ccc(Br)cc1)N1CCn2cccc2C1c1cccnc1 nan
1472482 19844 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 4 0 4 4.6 O=c1cc(N2CCCCC2)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 nan
CHEMBL1302054 19844 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 4 0 4 4.6 O=c1cc(N2CCCCC2)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 nan
2239590 19851 None 14 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 9 3.1 COC(=O)c1c(NC(=O)CSc2nnnn2-c2ccccc2)sc2c1CCCC2 nan
CHEMBL1302133 19851 None 14 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 9 3.1 COC(=O)c1c(NC(=O)CSc2nnnn2-c2ccccc2)sc2c1CCCC2 nan
2998537 19854 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 6 1 5 4.1 CCCn1c(NC(=O)c2ccc(Cl)c(S(=O)(=O)N3CCCC3)c2)nc2ccccc21 nan
CHEMBL1302158 19854 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 6 1 5 4.1 CCCn1c(NC(=O)c2ccc(Cl)c(S(=O)(=O)N3CCCC3)c2)nc2ccccc21 nan
1834882 19866 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 2 0 4 2.6 O=C1ON=C(c2ccccc2)/C1=C\c1ccco1 nan
CHEMBL1302233 19866 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 2 0 4 2.6 O=C1ON=C(c2ccccc2)/C1=C\c1ccco1 nan
2940774 19868 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 6 2 5 3.3 Cc1ccc(C(=O)Nc2ccccc2C(=O)NC2CCCCC2)cc1S(=O)(=O)N1CCOCC1 nan
CHEMBL1302244 19868 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 6 2 5 3.3 Cc1ccc(C(=O)Nc2ccccc2C(=O)NC2CCCCC2)cc1S(=O)(=O)N1CCOCC1 nan
2871969 19876 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 6 2 8 3.1 CCOc1nc(Nc2ccc([N+](=O)[O-])cc2)nc(NC(C)(C)C)n1 nan
CHEMBL1302288 19876 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 6 2 8 3.1 CCOc1nc(Nc2ccc([N+](=O)[O-])cc2)nc(NC(C)(C)C)n1 nan
1310291 19882 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 2.7 COc1ccc(OC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)cc1 nan
CHEMBL1302347 19882 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 2.7 COc1ccc(OC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)cc1 nan
16194409 19887 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 520 9 1 7 3.9 Cc1noc(/C=C/c2cccs2)c1S(=O)(=O)N1CCC(C(=O)NCCCN2CCCC(C)C2)CC1 nan
CHEMBL1302373 19887 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 520 9 1 7 3.9 Cc1noc(/C=C/c2cccs2)c1S(=O)(=O)N1CCC(C(=O)NCCCN2CCCC(C)C2)CC1 nan
16197121 19895 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 8 2 5 5.3 CCO[C@H]1OC(C(=O)Nc2ccccc2)=C[C@@H](c2csc3ccccc23)[C@@H]1CCCO nan
CHEMBL1302410 19895 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 8 2 5 5.3 CCO[C@H]1OC(C(=O)Nc2ccccc2)=C[C@@H](c2csc3ccccc23)[C@@H]1CCCO nan
2006346 19898 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 5 1 8 2.4 Cc1ccc(S(=O)(=O)/C(C#N)=C/c2c(N3CCC(C(N)=O)CC3)nc3c(C)cccn3c2=O)cc1 nan
CHEMBL1302449 19898 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 5 1 8 2.4 Cc1ccc(S(=O)(=O)/C(C#N)=C/c2c(N3CCC(C(N)=O)CC3)nc3c(C)cccn3c2=O)cc1 nan
989652 19905 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 2 2 2 5.0 CC(C)(C)N(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 nan
CHEMBL1302492 19905 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 2 2 2 5.0 CC(C)(C)N(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 nan
3242341 19907 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 9 1 8 2.5 CCCN(CCC)c1nc(NC2CCN(C(=O)OCC)CC2)nc(OC)n1 nan
CHEMBL1302503 19907 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 9 1 8 2.5 CCCN(CCC)c1nc(NC2CCN(C(=O)OCC)CC2)nc(OC)n1 nan
664025 19911 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 7 2 5 4.5 C=C(C)COc1ccc(-c2n[nH]cc2Oc2ccccc2OC)c(O)c1 nan
CHEMBL1302523 19911 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 7 2 5 4.5 C=C(C)COc1ccc(-c2n[nH]cc2Oc2ccccc2OC)c(O)c1 nan
4393128 19912 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 4 1 3 3.8 O=C(COC(=O)C12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 nan
CHEMBL1302530 19912 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 4 1 3 3.8 O=C(COC(=O)C12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 nan
2028520 19915 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 4 0 6 4.4 COc1ccc(Cn2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 nan
CHEMBL1302551 19915 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 4 0 6 4.4 COc1ccc(Cn2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1 nan
2434551 19925 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 6 0 7 3.4 COc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1C(=O)OCc1c(C)noc1C nan
CHEMBL1302635 19925 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 6 0 7 3.4 COc1ccc(S(=O)(=O)N2CCc3ccccc32)cc1C(=O)OCc1c(C)noc1C nan
4885144 19927 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 4 1 6 3.9 c1cncc(-c2nc(NCC3COc4ccccc4O3)c3ccccc3n2)c1 nan
CHEMBL1302642 19927 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 4 1 6 3.9 c1cncc(-c2nc(NCC3COc4ccccc4O3)c3ccccc3n2)c1 nan
4522912 19928 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 5 0 4 5.9 Fc1ccc(Cn2c(SCc3ccc(F)c(C(F)(F)F)c3)nnc2C(F)(F)F)cc1 nan
CHEMBL1302643 19928 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 5 0 4 5.9 Fc1ccc(Cn2c(SCc3ccc(F)c(C(F)(F)F)c3)nnc2C(F)(F)F)cc1 nan
227464 19932 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 2 6 5.2 Cn1ncc2c(Nc3ccccc3Cl)nc(Nc3ccccc3Cl)nc21 nan
CHEMBL1302656 19932 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 2 6 5.2 Cn1ncc2c(Nc3ccccc3Cl)nc(Nc3ccccc3Cl)nc21 nan
1506296 19939 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 2 0 5 4.3 CC1CCN(c2nc(-c3ccco3)c3c(c2C#N)CC(C)(C)OC3)CC1 nan
CHEMBL1302722 19939 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 2 0 5 4.3 CC1CCN(c2nc(-c3ccco3)c3c(c2C#N)CC(C)(C)OC3)CC1 nan
3244233 19941 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 8 2 5 3.2 COCCNC(=O)c1ccc(N2CCCCC2)c(NS(=O)(=O)c2ccc(C)cc2)c1 nan
CHEMBL1302730 19941 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 8 2 5 3.2 COCCNC(=O)c1ccc(N2CCCCC2)c(NS(=O)(=O)c2ccc(C)cc2)c1 nan
658309 19950 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 2 5 3.2 COC(=O)c1[nH]c2ccc(C)cc2c1NC(=O)CN1CCN(c2ccc(F)cc2)CC1 nan
CHEMBL1302822 19950 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 2 5 3.2 COC(=O)c1[nH]c2ccc(C)cc2c1NC(=O)CN1CCN(c2ccc(F)cc2)CC1 nan
2841560 19954 None 22 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 7 3.5 CC(=O)OC1c2c(ccc3ccc(=O)oc23)OC(C)(C)C1OC(=O)CC(C)C nan
CHEMBL1302867 19954 None 22 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 7 3.5 CC(=O)OC1c2c(ccc3ccc(=O)oc23)OC(C)(C)C1OC(=O)CC(C)C nan
881454 19961 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 1 2 5.1 Cc1cccc(C)c1NC(=O)/C(=C/c1ccco1)c1ccccc1 nan
CHEMBL1302903 19961 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 1 2 5.1 Cc1cccc(C)c1NC(=O)/C(=C/c1ccco1)c1ccccc1 nan
2198843 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
CHEMBL1302946 19964 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
9550710 19976 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 8 1 5 4.7 CCOc1ccc(CCNC(=O)c2cc3sc(Cl)cc3n2C)cc1OCC nan
CHEMBL1303036 19976 None 32 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 8 1 5 4.7 CCOc1ccc(CCNC(=O)c2cc3sc(Cl)cc3n2C)cc1OCC nan
700464 19978 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 5 3.9 COC(=O)c1sccc1NC(=O)CSc1ccc(Cl)cc1 nan
CHEMBL1303042 19978 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 5 1 5 3.9 COC(=O)c1sccc1NC(=O)CSc1ccc(Cl)cc1 nan
651220 19982 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 6 1 7 2.3 COc1ccc(NC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)OCCO3)c2ncccc12 nan
CHEMBL1303092 19982 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 6 1 7 2.3 COc1ccc(NC(=O)CN(C)S(=O)(=O)c2ccc3c(c2)OCCO3)c2ncccc12 nan
654704 19983 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 0 8 2.7 CC1Cc2ccccc2N1C(=O)CSc1nnc(Cn2nnc3ccccc32)n1C nan
CHEMBL1303109 19983 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 0 8 2.7 CC1Cc2ccccc2N1C(=O)CSc1nnc(Cn2nnc3ccccc32)n1C nan
648492 19987 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 450 7 0 7 3.5 COc1ccc(Cn2nnnc2C(c2ccc(F)cc2)N2CCN(C3CCCC3)CC2)cc1 nan
CHEMBL1303172 19987 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 450 7 0 7 3.5 COc1ccc(Cn2nnnc2C(c2ccc(F)cc2)N2CCN(C3CCCC3)CC2)cc1 nan
2136882 19994 None 5 Human Functional pPotency = 5 5.0 -12 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccccc4)c-3cn(Cc3ccccc3F)c2cc1OC nan
CHEMBL1303193 19994 None 5 Human Functional pPotency = 5 5.0 -12 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccccc4)c-3cn(Cc3ccccc3F)c2cc1OC nan
1105872 19999 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 0 7 4.4 c1ccc(Cn2c(CSc3nnnn3-c3ccccc3)nc3ccccc32)cc1 nan
CHEMBL1303226 19999 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 6 0 7 4.4 c1ccc(Cn2c(CSc3nnnn3-c3ccccc3)nc3ccccc32)cc1 nan
6019083 20003 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 0 6 4.7 COc1ccc(/C=C(/C(=O)c2cccs2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
CHEMBL1303281 20003 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 0 6 4.7 COc1ccc(/C=C(/C(=O)c2cccs2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
3153379 20005 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 2 4 4.0 CCCC(=O)Nc1sc2c(c1C(=O)Nc1ccccn1)CCCC2 nan
CHEMBL1303305 20005 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 2 4 4.0 CCCC(=O)Nc1sc2c(c1C(=O)Nc1ccccn1)CCCC2 nan
2325820 20008 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 4 0 6 2.6 Cc1cc(C#N)c(C)n1-c1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCC1 nan
CHEMBL1303323 20008 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 4 0 6 2.6 Cc1cc(C#N)c(C)n1-c1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCCC1 nan
3179856 20014 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 6 2 2 4.9 CC(C(=O)NC1CCCC1)N(C(=O)c1ccc(-c2ccccc2)[nH]1)c1ccccc1F nan
CHEMBL1303348 20014 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 6 2 2 4.9 CC(C(=O)NC1CCCC1)N(C(=O)c1ccc(-c2ccccc2)[nH]1)c1ccccc1F nan
3240330 20021 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 4 1 5 2.8 O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccc(F)cc2)CC1 nan
CHEMBL1303401 20021 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 4 1 5 2.8 O=C(c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1)N1CCN(c2ccc(F)cc2)CC1 nan
649753 20024 None 2 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 9 1 10 2.5 CCOC(=O)Cc1csc(NC(=O)CSc2nnnn2-c2ccc(CC)cc2)n1 nan
CHEMBL1303411 20024 None 2 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 9 1 10 2.5 CCOC(=O)Cc1csc(NC(=O)CSc2nnnn2-c2ccc(CC)cc2)n1 nan
3241683 20029 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 3 1 6 3.9 O=C(Nc1ccc(Cl)cc1)N1CCN(c2ccc3nnc(-c4ccc(F)cc4)n3n2)CC1 nan
CHEMBL1303443 20029 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 3 1 6 3.9 O=C(Nc1ccc(Cl)cc1)N1CCN(c2ccc3nnc(-c4ccc(F)cc4)n3n2)CC1 nan
4269977 20045 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 1 4 2.8 O=C(Cc1nc(=O)c2ccccc2s1)Nc1ccccc1 nan
CHEMBL1303553 20045 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 3 1 4 2.8 O=C(Cc1nc(=O)c2ccccc2s1)Nc1ccccc1 nan
4092119 20048 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 523 7 2 7 4.3 O=S(=O)(Nc1nc2ccccc2nc1Nc1cccc(S(=O)(=O)N2CCCCC2)c1)c1ccccc1 nan
CHEMBL1303580 20048 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 523 7 2 7 4.3 O=S(=O)(Nc1nc2ccccc2nc1Nc1cccc(S(=O)(=O)N2CCCCC2)c1)c1ccccc1 nan
2956740 20051 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 2 2 6 3.7 CCOc1cc2c3c(c1)C1(C(=O)N3C(C)(C)C=C2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
CHEMBL1303628 20051 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 2 2 6 3.7 CCOc1cc2c3c(c1)C1(C(=O)N3C(C)(C)C=C2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
2037235 20053 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 1 7 3.3 Cc1cc(NC(=O)CCS(=O)(=O)c2nc(-c3ccccc3)cc(C(F)(F)F)n2)no1 nan
CHEMBL1303635 20053 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 1 7 3.3 Cc1cc(NC(=O)CCS(=O)(=O)c2nc(-c3ccccc3)cc(C(F)(F)F)n2)no1 nan
2998683 20058 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 6 1 7 3.9 CC(C)Cn1c(SC(C)C(=O)Nc2ccc3c(c2)OCCO3)nc2ccccc2c1=O nan
CHEMBL1303668 20058 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 6 1 7 3.9 CC(C)Cn1c(SC(C)C(=O)Nc2ccc3c(c2)OCCO3)nc2ccccc2c1=O nan
2867844 20059 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 9 0 8 4.2 COc1cc(OC)c(OC)cc1CN(C)C(c1ccccc1)c1nnnn1-c1ccccc1C nan
CHEMBL1303688 20059 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 9 0 8 4.2 COc1cc(OC)c(OC)cc1CN(C)C(c1ccccc1)c1nnnn1-c1ccccc1C nan
1803281 20072 None 6 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 337 4 1 3 3.0 CN(C)c1ccc(/C=C2\NC(=S)N(Cc3ccccc3)C2=O)cc1 nan
CHEMBL1303807 20072 None 6 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 337 4 1 3 3.0 CN(C)c1ccc(/C=C2\NC(=S)N(Cc3ccccc3)C2=O)cc1 nan
1479311 20075 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 6 0 4 5.1 C#CCn1c(S(=O)(=O)Cc2ccc(C)cc2)nc(-c2ccccc2)c1-c1ccccc1 nan
CHEMBL1303819 20075 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 6 0 4 5.1 C#CCn1c(S(=O)(=O)Cc2ccc(C)cc2)nc(-c2ccccc2)c1-c1ccccc1 nan
3242656 20077 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 486 4 1 6 3.3 O=C(Nc1ccc2c(c1)OCCO2)C1CCN(S(=O)(=O)c2ccc(Br)s2)CC1 nan
CHEMBL1303834 20077 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 486 4 1 6 3.3 O=C(Nc1ccc2c(c1)OCCO2)C1CCN(S(=O)(=O)c2ccc(Br)s2)CC1 nan
3180842 20085 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 10 1 7 3.5 Cc1ccc(-c2nnn(CC(=O)N(c3ccccc3F)C(CC(C)C)C(=O)NCC3CCCO3)n2)cc1 nan
CHEMBL1303875 20085 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 10 1 7 3.5 Cc1ccc(-c2nnn(CC(=O)N(c3ccccc3F)C(CC(C)C)C(=O)NCC3CCCO3)n2)cc1 nan
1385107 20087 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 2 4 4.1 NC(=O)Cc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1 nan
CHEMBL1303880 20087 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 5 2 4 4.1 NC(=O)Cc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1 nan
5730624 20097 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 2 6 4.7 Cc1noc(NS(=O)(=O)c2ccc(N/C=C\C(=O)c3ccc(Br)cc3)cc2)c1C nan
CHEMBL1304007 20097 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 2 6 4.7 Cc1noc(NS(=O)(=O)c2ccc(N/C=C\C(=O)c3ccc(Br)cc3)cc2)c1C nan
16189403 20114 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 510 11 1 4 6.3 CCOc1ccc(NC(=S)N(CCCN2CCCC2)Cc2cccn2Cc2ccc(Cl)cc2)cc1 nan
CHEMBL1304162 20114 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 510 11 1 4 6.3 CCOc1ccc(NC(=S)N(CCCN2CCCC2)Cc2cccn2Cc2ccc(Cl)cc2)cc1 nan
5722655 20117 None 3 Human Functional pPotency = 5 5.0 -17 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 8 1 4 5.6 CCCOc1cc(N(CC)CC)ccc1/C=C(/C#N)c1nc2cc(C)ccc2[nH]1 nan
CHEMBL1304179 20117 None 3 Human Functional pPotency = 5 5.0 -17 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 8 1 4 5.6 CCCOc1cc(N(CC)CC)ccc1/C=C(/C#N)c1nc2cc(C)ccc2[nH]1 nan
3241263 20122 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 1 5 4.4 COc1ccccc1-c1cc(C(F)(F)F)nc(NCc2ccco2)n1 nan
CHEMBL1304205 20122 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 1 5 4.4 COc1ccccc1-c1cc(C(F)(F)F)nc(NCc2ccco2)n1 nan
2976358 20146 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 0 7 2.5 Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1 nan
CHEMBL1304386 20146 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 0 7 2.5 Cc1ccc(OCC(=O)N2CCN(c3ccc([N+](=O)[O-])c(N4CCOCC4)c3)CC2)cc1 nan
2768231 20153 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 6 0 6 5.8 CCn1c(SCc2ccc(C)cc2)nnc1-c1cnn(-c2ccccc2)c1C(F)(F)F nan
CHEMBL1304478 20153 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 6 0 6 5.8 CCn1c(SCc2ccc(C)cc2)nnc1-c1cnn(-c2ccccc2)c1C(F)(F)F nan
659623 20163 None 5 Human Functional pPotency = 5 5.0 -5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 3 1 6 3.3 Fc1ccc2[nH]c3c(N4CCN(Cc5ccc6c(c5)OCO6)CC4)ncnc3c2c1 nan
CHEMBL1304582 20163 None 5 Human Functional pPotency = 5 5.0 -5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 3 1 6 3.3 Fc1ccc2[nH]c3c(N4CCN(Cc5ccc6c(c5)OCO6)CC4)ncnc3c2c1 nan
947836 20166 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 4 3 4 3.0 O=C(/C=C/c1cccs1)NC(=S)Nc1ccc(C(=O)O)cc1 nan
CHEMBL1304598 20166 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 4 3 4 3.0 O=C(/C=C/c1cccs1)NC(=S)Nc1ccc(C(=O)O)cc1 nan
2213723 20179 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 0 4 5.6 Cc1ccc(-c2noc(CN(C(=O)C(c3ccccc3)c3ccccc3)C(C)C)n2)cc1 nan
CHEMBL1304694 20179 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 0 4 5.6 Cc1ccc(-c2noc(CN(C(=O)C(c3ccccc3)c3ccccc3)C(C)C)n2)cc1 nan
659633 20193 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 9 1 7 2.7 COCCCNC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1304829 20193 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 9 1 7 2.7 COCCCNC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
2217893 20217 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 482 8 1 6 3.6 COc1ccc(C)cc1S(=O)(=O)N(CC(=O)Nc1ccc2c(c1)OCCO2)Cc1ccccc1 nan
CHEMBL1305042 20217 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 482 8 1 6 3.6 COc1ccc(C)cc1S(=O)(=O)N(CC(=O)Nc1ccc2c(c1)OCCO2)Cc1ccccc1 nan
785305 20225 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 4 1 3 4.4 Cc1cccc(NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CCCC2)c1 nan
CHEMBL1305118 20225 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 4 1 3 4.4 Cc1cccc(NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CCCC2)c1 nan
6407377 20240 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 3 0 5 4.6 Cc1ccc(-c2nnc(N3CCN(C(=O)c4cccs4)CC3)c3ccccc23)cc1 nan
CHEMBL1305231 20240 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 3 0 5 4.6 Cc1ccc(-c2nnc(N3CCN(C(=O)c4cccs4)CC3)c3ccccc23)cc1 nan
5308071 20249 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 5 1 4 4.1 O=C(Nc1ncc(Br)s1)C(Cc1ccccc1)n1cccc1 nan
CHEMBL1305312 20249 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 5 1 4 4.1 O=C(Nc1ncc(Br)s1)C(Cc1ccccc1)n1cccc1 nan
1303069 20251 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 3 0 5 4.6 Clc1cccc(Cl)c1Cn1cnc2c(N3CCCCCC3)ncnc21 nan
CHEMBL1305326 20251 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 3 0 5 4.6 Clc1cccc(Cl)c1Cn1cnc2c(N3CCCCCC3)ncnc21 nan
3094959 20256 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 4 3 3 5.0 O=C(NC(NC(=S)Nc1ccc(Cl)c(Cl)c1)C(Cl)(Cl)Cl)c1ccco1 nan
CHEMBL1305375 20256 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 4 3 3 5.0 O=C(NC(NC(=S)Nc1ccc(Cl)c(Cl)c1)C(Cl)(Cl)Cl)c1ccco1 nan
649403 20259 None 4 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 1 10 4.0 CCOC(=O)Cn1nnnc1C(CC)N(Cc1cccs1)Cc1cc2cc(C)ccc2nc1O nan
CHEMBL1305402 20259 None 4 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 1 10 4.0 CCOC(=O)Cn1nnnc1C(CC)N(Cc1cccs1)Cc1cc2cc(C)ccc2nc1O nan
16745791 20260 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 507 5 2 4 7.8 O=C(Nc1ccc(-c2csc(Nc3cccc(C(F)(F)F)c3)n2)cc1)c1cccc(C(F)(F)F)c1 nan
CHEMBL1305406 20260 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 507 5 2 4 7.8 O=C(Nc1ccc(-c2csc(Nc3cccc(C(F)(F)F)c3)n2)cc1)c1cccc(C(F)(F)F)c1 nan
667209 20261 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 5 0 7 3.5 COc1ccc(Cc2nn3c(-c4ccccc4OC)nnc3s2)cc1 nan
CHEMBL1305409 20261 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 5 0 7 3.5 COc1ccc(Cc2nn3c(-c4ccccc4OC)nnc3s2)cc1 nan
5983846 20283 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 3 5.7 CC(C)c1ccc(/C=C(\c2nc3ccccc3[nH]2)S(=O)(=O)c2ccccc2)cc1 nan
CHEMBL1305642 20283 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 1 3 5.7 CC(C)c1ccc(/C=C(\c2nc3ccccc3[nH]2)S(=O)(=O)c2ccccc2)cc1 nan
3596973 20306 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 8 1 6 3.8 CCN(CC)S(=O)(=O)c1ccc(N2CCCCC2)c(C(=O)Nc2ccccc2N2CCOCC2)c1 nan
CHEMBL1305806 20306 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 8 1 6 3.8 CCN(CC)S(=O)(=O)c1ccc(N2CCCCC2)c(C(=O)Nc2ccccc2N2CCOCC2)c1 nan
4666612 20310 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 10 1 8 5.8 CCCCSc1nc(SCC(=O)NCc2ccco2)c2c3c(sc2n1)COC(C)(CC)C3 nan
CHEMBL1305837 20310 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 10 1 8 5.8 CCCCSc1nc(SCC(=O)NCc2ccco2)c2c3c(sc2n1)COC(C)(CC)C3 nan
1893498 20313 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 4 1 4 4.7 Cc1ccc(C2=N/C(=C/c3cccs3)C(=O)N2Nc2ccccc2)cc1 nan
CHEMBL1305848 20313 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 4 1 4 4.7 Cc1ccc(C2=N/C(=C/c3cccs3)C(=O)N2Nc2ccccc2)cc1 nan
3190915 20314 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 7 2 3 6.1 O=C(NC1CCCCC1)C(c1cccs1)N(C(=O)Cc1c[nH]c2ccccc12)c1ccc(F)cc1 nan
CHEMBL1305849 20314 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 7 2 3 6.1 O=C(NC1CCCCC1)C(c1cccs1)N(C(=O)Cc1c[nH]c2ccccc12)c1ccc(F)cc1 nan
3193421 20317 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 6 0 5 4.7 CCN(Cc1ccccc1)C(c1ccc(Cl)cc1)c1nnnn1C(C)(C)C nan
CHEMBL1305860 20317 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 6 0 5 4.7 CCN(Cc1ccccc1)C(c1ccc(Cl)cc1)c1nnnn1C(C)(C)C nan
2408451 20328 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 1 5 5.6 N#Cc1c(NC(=O)CSc2ccccn2)oc(-c2ccccc2)c1-c1ccccc1 nan
CHEMBL1305926 20328 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 1 5 5.6 N#Cc1c(NC(=O)CSc2ccccn2)oc(-c2ccccc2)c1-c1ccccc1 nan
2313393 20362 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 1 3 5.4 O=C(c1ccccc1Nc1ccc(SC(F)F)cc1)N1CCCCC1 nan
CHEMBL1306134 20362 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 1 3 5.4 O=C(c1ccccc1Nc1ccc(SC(F)F)cc1)N1CCCCC1 nan
2158311 20367 None 10 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 5 5.1 O=C(CSc1ncnc2c1oc1ccccc12)Nc1ccccc1C(F)(F)F nan
CHEMBL1306166 20367 None 10 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 5 5.1 O=C(CSc1ncnc2c1oc1ccccc12)Nc1ccccc1C(F)(F)F nan
653150 20368 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 8 2 6 5.5 CC(=O)Nc1cccc(NC(=O)CSc2ncc(-c3ccc(Cl)cc3)n2Cc2ccco2)c1 nan
CHEMBL1306181 20368 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 8 2 6 5.5 CC(=O)Nc1cccc(NC(=O)CSc2ncc(-c3ccc(Cl)cc3)n2Cc2ccco2)c1 nan
666739 20369 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 10 1 8 4.9 COc1ccccc1NC(=O)CSc1nnc(COc2ccc(Cl)cc2)n1Cc1ccco1 nan
CHEMBL1306196 20369 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 10 1 8 4.9 COc1ccccc1NC(=O)CSc1nnc(COc2ccc(Cl)cc2)n1Cc1ccco1 nan
867879 20382 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 277 3 2 4 3.9 Cc1cc(Nc2ccccc2)nc(-c2ccccc2O)n1 nan
CHEMBL1306258 20382 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 277 3 2 4 3.9 Cc1cc(Nc2ccccc2)nc(-c2ccccc2O)n1 nan
16197030 20398 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 7 2 6 5.4 CC(=O)n1cc([C@H]2C=C(C(=O)Nc3ccccc3)O[C@@H](OCc3ccc(CO)cc3)C2)c2ccccc21 nan
CHEMBL1306471 20398 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 7 2 6 5.4 CC(=O)n1cc([C@H]2C=C(C(=O)Nc3ccccc3)O[C@@H](OCc3ccc(CO)cc3)C2)c2ccccc21 nan
833786 20400 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 3 1 4 4.2 Sc1nc(SCc2ccccc2)nc2ccccc12 nan
CHEMBL1306480 20400 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 3 1 4 4.2 Sc1nc(SCc2ccccc2)nc2ccccc12 nan
888109 20406 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 0 4 3.7 Cc1nc(-c2ccc(S(=O)(=O)N3CCCCCC3)cc2)cs1 nan
CHEMBL1306528 20406 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 0 4 3.7 Cc1nc(-c2ccc(S(=O)(=O)N3CCCCCC3)cc2)cs1 nan
1483859 20407 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 5 0 4 5.2 Cc1cc(C(=O)CSc2ccc(Cl)cc2)cc(C)c1OC(=S)N(C)C nan
CHEMBL1306558 20407 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 5 0 4 5.2 Cc1cc(C(=O)CSc2ccc(Cl)cc2)cc(C)c1OC(=S)N(C)C nan
660792 20408 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 9 0 8 4.0 CCCCN(CCCC)C(=O)CSc1nnc2n(C)c(=O)c3c4c(sc3n12)CCCC4 nan
CHEMBL1306570 20408 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 9 0 8 4.0 CCCCN(CCCC)C(=O)CSc1nnc2n(C)c(=O)c3c4c(sc3n12)CCCC4 nan
1792513 20420 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 7 3 5 3.4 CCOc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)C(C)C)cc2)cc1 nan
CHEMBL1306671 20420 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 7 3 5 3.4 CCOc1ccc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)C(C)C)cc2)cc1 nan
2907540 20456 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 4 1 5 4.2 Cc1ccc(NC(=O)c2cc(N3C(=O)C4CC=CCC4C3=O)ccc2N2CCOCC2)cc1Cl nan
CHEMBL1306964 20456 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 4 1 5 4.2 Cc1ccc(NC(=O)c2cc(N3C(=O)C4CC=CCC4C3=O)ccc2N2CCOCC2)cc1Cl nan
6224173 20474 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 1 4 5.6 COc1ccccc1/C=C(/CC(=O)NCc1ccccc1)c1nc2ccccc2s1 nan
CHEMBL1307104 20474 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 1 4 5.6 COc1ccccc1/C=C(/CC(=O)NCc1ccccc1)c1nc2ccccc2s1 nan
2221764 20478 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 5 1 5 4.2 CCC(=O)Oc1ccc(C(=O)Nc2ccc3c(c2)C(=O)N(C2CCCCC2)C3=O)cc1 nan
CHEMBL1307125 20478 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 5 1 5 4.2 CCC(=O)Oc1ccc(C(=O)Nc2ccc3c(c2)C(=O)N(C2CCCCC2)C3=O)cc1 nan
1481943 20490 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 2 1 4 1.7 NC(=O)C1CCN(C2=C(Cl)C(=O)c3ccccc3C2=O)CC1 nan
CHEMBL1307207 20490 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 318 2 1 4 1.7 NC(=O)C1CCN(C2=C(Cl)C(=O)c3ccccc3C2=O)CC1 nan
649706 20501 None 0 Human Functional pPotency = 5 5.0 -3 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 5 0 7 4.3 CCN(C(=O)c1ccc(C(C)(C)C)cc1)c1nnc(Cn2nnc3ccccc32)s1 nan
CHEMBL1307319 20501 None 0 Human Functional pPotency = 5 5.0 -3 5
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 5 0 7 4.3 CCN(C(=O)c1ccc(C(C)(C)C)cc1)c1nnc(Cn2nnc3ccccc32)s1 nan
2999594 20509 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 4 0 6 4.0 Cc1nn(-c2ccc(F)cc2)c2sc(C(=O)OCC(=O)N3CCC(C)CC3)cc12 nan
CHEMBL1307389 20509 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 4 0 6 4.0 Cc1nn(-c2ccc(F)cc2)c2sc(C(=O)OCC(=O)N3CCC(C)CC3)cc12 nan
1401022 20521 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 5 1 1 5.4 CCc1ccccc1NC(=O)/C(=C/c1ccccc1)c1ccccc1 nan
CHEMBL1307473 20521 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 5 1 1 5.4 CCc1ccccc1NC(=O)/C(=C/c1ccccc1)c1ccccc1 nan
1112949 20526 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 8 0 3 5.3 COc1ccccc1C(CC(=O)c1ccccc1)CC(=O)c1ccccc1 nan
CHEMBL1307516 20526 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 8 0 3 5.3 COc1ccccc1C(CC(=O)c1ccccc1)CC(=O)c1ccccc1 nan
903952 20544 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 0 6 3.9 COc1ccc(/C=C2/N=C(c3cccs3)OC2=O)cc1OC(C)C nan
CHEMBL1307668 20544 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 0 6 3.9 COc1ccc(/C=C2/N=C(c3cccs3)OC2=O)cc1OC(C)C nan
3939245 20546 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 0 4 4.5 Cn1c(SCC(=O)N(Cc2ccccc2)C(C)(C)C)nc2ccccc21 nan
CHEMBL1307675 20546 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 0 4 4.5 Cn1c(SCC(=O)N(Cc2ccccc2)C(C)(C)C)nc2ccccc21 nan
2091443 20554 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 344 5 1 3 4.6 O=C(CN1CCCCC1)Nc1cc(Cl)ccc1Oc1ccccc1 nan
CHEMBL1307729 20554 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 344 5 1 3 4.6 O=C(CN1CCCCC1)Nc1cc(Cl)ccc1Oc1ccccc1 nan
1453279 20556 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 4 2 5 5.2 Cc1sc2nc(CN(C(=O)NC3CCCCC3)C3CCCCC3)nc(O)c2c1C nan
CHEMBL1307736 20556 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 4 2 5 5.2 Cc1sc2nc(CN(C(=O)NC3CCCCC3)C3CCCCC3)nc(O)c2c1C nan
5735148 20560 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 5.3 COc1ccc(C(=O)/C(=C/c2cccs2)c2nc3ccccc3o2)cc1 nan
CHEMBL1307792 20560 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 5.3 COc1ccc(C(=O)/C(=C/c2cccs2)c2nc3ccccc3o2)cc1 nan
9550949 20572 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 5 1 5 4.2 CCOC(=O)N1CCC(NC(=O)c2ccc3c(c2)N(Cc2ccccc2)CCS3)CC1 nan
CHEMBL1307850 20572 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 5 1 5 4.2 CCOC(=O)N1CCC(NC(=O)c2ccc3c(c2)N(Cc2ccccc2)CCS3)CC1 nan
2726627 20575 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 1 8 3.9 Cc1onc(-c2cccc(Cl)c2Cl)c1C(=O)ON=C(N)c1ccc([N+](=O)[O-])o1 nan
6298222 20575 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 1 8 3.9 Cc1onc(-c2cccc(Cl)c2Cl)c1C(=O)ON=C(N)c1ccc([N+](=O)[O-])o1 nan
9566279 20575 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 1 8 3.9 Cc1onc(-c2cccc(Cl)c2Cl)c1C(=O)ON=C(N)c1ccc([N+](=O)[O-])o1 nan
CHEMBL1307861 20575 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 1 8 3.9 Cc1onc(-c2cccc(Cl)c2Cl)c1C(=O)ON=C(N)c1ccc([N+](=O)[O-])o1 nan
1472484 20581 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 5 0 5 4.0 COc1ccc(Cn2nc(-c3ccccc3)c(N3CCCCC3)cc2=O)cc1 nan
CHEMBL1307895 20581 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 375 5 0 5 4.0 COc1ccc(Cn2nc(-c3ccccc3)c(N3CCCCC3)cc2=O)cc1 nan
665308 20591 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 6 2 6 4.1 C=C(C)COc1ccc(-c2nc(N)ncc2-c2ccc(OC)cc2)c(O)c1 nan
CHEMBL1308000 20591 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 6 2 6 4.1 C=C(C)COc1ccc(-c2nc(N)ncc2-c2ccc(OC)cc2)c(O)c1 nan
645675 20595 None 2 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 4 1 10 3.0 Oc1nc2cc3c(cc2cc1C(c1nnnn1C1CCCC1)N1CCSCC1)OCCO3 nan
CHEMBL1308032 20595 None 2 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 4 1 10 3.0 Oc1nc2cc3c(cc2cc1C(c1nnnn1C1CCCC1)N1CCSCC1)OCCO3 nan
647686 20596 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 0 7 3.8 COc1cc(OC)cc(-c2nnc(SCC(=O)N3CCCc4ccccc43)o2)c1 nan
CHEMBL1308043 20596 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 0 7 3.8 COc1cc(OC)cc(-c2nnc(SCC(=O)N3CCCc4ccccc43)o2)c1 nan
4032625 20609 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 4 2 2 4.3 O=C(NCC1CCCC(CNC(=O)N2CCc3ccccc32)C1)N1CCc2ccccc21 nan
CHEMBL1308130 20609 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 4 2 2 4.3 O=C(NCC1CCCC(CNC(=O)N2CCc3ccccc32)C1)N1CCc2ccccc21 nan
135473420 20613 None 4 Human Functional pPotency = 5 5.0 -5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 2 5 5.0 Cc1ccc(CNCc2cc3c(C(C)(C)C)nn(-c4ccccc4)c3nc2O)cc1 nan
CHEMBL1308168 20613 None 4 Human Functional pPotency = 5 5.0 -5 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 2 5 5.0 Cc1ccc(CNCc2cc3c(C(C)(C)C)nn(-c4ccccc4)c3nc2O)cc1 nan
4030276 20614 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 1 5 3.7 Cc1nn(-c2ccccc2)c(C)c1C(=O)OCC(=O)NC12CC3CC(CC(C3)C1)C2 nan
CHEMBL1308217 20614 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 1 5 3.7 Cc1nn(-c2ccccc2)c(C)c1C(=O)OCC(=O)NC12CC3CC(CC(C3)C1)C2 nan
4366447 20634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 512 7 1 8 4.5 COc1ccc(C2c3c(ncn(CCCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
CHEMBL1308383 20634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 512 7 1 8 4.5 COc1ccc(C2c3c(ncn(CCCN4CCOCC4)c3=N)Oc3ccc4ccccc4c32)cc1OC nan
1310757 20635 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 4 0 6 4.5 Cc1cc(/C=C2\SC(=S)N(Cc3ccco3)C2=O)c(C)n1-c1cccnc1 nan
CHEMBL1308386 20635 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 4 0 6 4.5 Cc1cc(/C=C2\SC(=S)N(Cc3ccco3)C2=O)c(C)n1-c1cccnc1 nan
664856 20647 None 5 Human Functional pPotency = 5 5.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 281 1 0 4 3.9 Cc1nc(N2CCC(C)CC2)c2oc3ccccc3c2n1 nan
CHEMBL1308461 20647 None 5 Human Functional pPotency = 5 5.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 281 1 0 4 3.9 Cc1nc(N2CCC(C)CC2)c2oc3ccccc3c2n1 nan
3751006 20648 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 9 3 7 3.2 COC(=O)c1sccc1NC(=O)CSc1ccccc1NC(=O)CNC(C)C nan
CHEMBL1308478 20648 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 9 3 7 3.2 COC(=O)c1sccc1NC(=O)CSc1ccccc1NC(=O)CNC(C)C nan
1040608 20650 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 6 0 5 4.9 CCN(CC)S(=O)(=O)c1cc(-c2nnc(-c3ccc(Br)cc3)o2)ccc1Cl nan
CHEMBL1308487 20650 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 6 0 5 4.9 CCN(CC)S(=O)(=O)c1cc(-c2nnc(-c3ccc(Br)cc3)o2)ccc1Cl nan
4180934 20661 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 5 0 7 2.8 C=CC(C)Sc1nc2c(c(=O)n(C)c(=O)n2C)n1Cc1ccccc1Cl nan
CHEMBL1308599 20661 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 5 0 7 2.8 C=CC(C)Sc1nc2c(c(=O)n(C)c(=O)n2C)n1Cc1ccccc1Cl nan
935829 20663 None 11 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 3 0 4 3.3 Cc1nc2ccccc2nc1SCC(=O)N1CCC(C)CC1 nan
CHEMBL1308605 20663 None 11 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 3 0 4 3.3 Cc1nc2ccccc2nc1SCC(=O)N1CCC(C)CC1 nan
3713241 20664 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 2 5 4.5 O=C(CSc1cn(CCNC(=O)c2cccs2)c2ccccc12)NCc1ccccc1 nan
CHEMBL1308607 20664 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 2 5 4.5 O=C(CSc1cn(CCNC(=O)c2cccs2)c2ccccc12)NCc1ccccc1 nan
2809108 20669 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 1 4 4.9 CC(=O)c1sc(-c2ccc(F)cc2)cc1NS(=O)(=O)c1ccc(C)cc1 nan
CHEMBL1308635 20669 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 1 4 4.9 CC(=O)c1sc(-c2ccc(F)cc2)cc1NS(=O)(=O)c1ccc(C)cc1 nan
7830051 20673 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 386 2 0 4 6.4 Cc1cc2c(cc1C)CSC(c1ccccc1OC(=O)C(C)(C)C)SC2 nan
CHEMBL1308665 20673 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 386 2 0 4 6.4 Cc1cc2c(cc1C)CSC(c1ccccc1OC(=O)C(C)(C)C)SC2 nan
900453 20687 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 2 0 4 2.8 Cc1cc(C=C2C(=O)N(C)C(=S)N(C)C2=O)c(C)n1C1CCCC1 nan
CHEMBL1308784 20687 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 2 0 4 2.8 Cc1cc(C=C2C(=O)N(C)C(=S)N(C)C2=O)c(C)n1C1CCCC1 nan
2998368 20693 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 0 6 4.5 Cc1noc(C)c1COc1ccc(C(=O)OCC(=O)N2CC3(C)CC2CC(C)(C)C3)cc1 nan
CHEMBL1308847 20693 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 0 6 4.5 Cc1noc(C)c1COc1ccc(C(=O)OCC(=O)N2CC3(C)CC2CC(C)(C)C3)cc1 nan
4670541 20712 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 1 2 9 1.4 NC1=NN=C(N2N=C(c3ccc(Br)cc3)CC2(O)C(F)(F)F)n2ncnc2C1 nan
CHEMBL1308991 20712 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 1 2 9 1.4 NC1=NN=C(N2N=C(c3ccc(Br)cc3)CC2(O)C(F)(F)F)n2ncnc2C1 nan
3093479 20733 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 510 6 3 5 4.9 COc1ccc(N=C(S)NC(NC(=O)c2cccc(Cl)c2)C(Cl)(Cl)Cl)c([N+](=O)[O-])c1 nan
CHEMBL1309183 20733 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 510 6 3 5 4.9 COc1ccc(N=C(S)NC(NC(=O)c2cccc(Cl)c2)C(Cl)(Cl)Cl)c([N+](=O)[O-])c1 nan
2303154 20734 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 6 1 7 4.2 CCCOC(=O)c1ccc(-c2c(C)noc2-c2ccc(OC)cc2O)o1 nan
CHEMBL1309205 20734 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 6 1 7 4.2 CCCOC(=O)c1ccc(-c2c(C)noc2-c2ccc(OC)cc2O)o1 nan
2876926 20736 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 12 1 6 6.9 CCCOP(=O)(OCCC)C(Nc1ccc(C(C)C)cc1)c1ccc([N+](=O)[O-])cc1 nan
CHEMBL1309216 20736 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 12 1 6 6.9 CCCOP(=O)(OCCC)C(Nc1ccc(C(C)C)cc1)c1ccc([N+](=O)[O-])cc1 nan
2201691 20741 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 4 0 3 4.9 O=C(c1ccccc1)c1cn(CC(=O)N2CCCc3ccccc32)c2ccccc12 nan
CHEMBL1309257 20741 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 4 0 3 4.9 O=C(c1ccccc1)c1cn(CC(=O)N2CCCc3ccccc32)c2ccccc12 nan
4099139 20742 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 9 2 6 4.4 O=C(CCCCCn1c(=S)[nH]c2ccc(N3CCOCC3)cc2c1=O)NCc1ccc(Cl)cc1 nan
CHEMBL1309265 20742 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 9 2 6 4.4 O=C(CCCCCn1c(=S)[nH]c2ccc(N3CCOCC3)cc2c1=O)NCc1ccc(Cl)cc1 nan
3183326 20747 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 1 9 3.8 COc1ccc(Cn2nnnc2C(c2cc3ccc(OC)cc3nc2O)N2CCC(C)CC2)cc1 nan
CHEMBL1309278 20747 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 1 9 3.8 COc1ccc(Cn2nnnc2C(c2cc3ccc(OC)cc3nc2O)N2CCC(C)CC2)cc1 nan
3958676 20748 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 3 2 4 3.2 Cc1cc(NC(=O)C2CCCC2)n(-c2nc3ccccc3[nH]2)n1 nan
CHEMBL1309281 20748 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 3 2 4 3.2 Cc1cc(NC(=O)C2CCCC2)n(-c2nc3ccccc3[nH]2)n1 nan
2387018 20751 None 22 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 283 3 0 2 4.3 Cn1c(-c2ccccc2)c(C(=O)CCl)c2ccccc21 nan
CHEMBL1309290 20751 None 22 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 283 3 0 2 4.3 Cn1c(-c2ccccc2)c(C(=O)CCl)c2ccccc21 nan
2684640 20754 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 4 1 5 5.1 COc1cc2c(cc1NC(=O)c1cccc([N+](=O)[O-])c1C)oc1ccccc12 nan
CHEMBL1309297 20754 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 4 1 5 5.1 COc1cc2c(cc1NC(=O)c1cccc([N+](=O)[O-])c1C)oc1ccccc12 nan
1265627 20756 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 5 1 3 4.2 CN(C1CCCCC1)S(=O)(=O)c1ccc(NC(=O)C2CCCCC2)cc1 nan
CHEMBL1309307 20756 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 5 1 3 4.2 CN(C1CCCCC1)S(=O)(=O)c1ccc(NC(=O)C2CCCCC2)cc1 nan
1201985 20757 None 7 Human Functional pPotency = 5 5.0 2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 6 0 6 3.8 O=C(CSc1nc2ccccc2nc1SCC(=O)N1CCCCC1)N1CCCCC1 nan
CHEMBL1309335 20757 None 7 Human Functional pPotency = 5 5.0 2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 6 0 6 3.8 O=C(CSc1nc2ccccc2nc1SCC(=O)N1CCCCC1)N1CCCCC1 nan
1319878 20768 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 7 1 4 6.1 Cc1sc(N(C(=O)CCc2ccccc2)c2ccc(C(=O)O)cc2)nc1-c1ccccc1 nan
CHEMBL1309417 20768 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 7 1 4 6.1 Cc1sc(N(C(=O)CCc2ccccc2)c2ccc(C(=O)O)cc2)nc1-c1ccccc1 nan
3239469 20769 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 6 2 8 3.7 O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3 nan
CHEMBL1309430 20769 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 6 2 8 3.7 O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3 nan
16190594 20771 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 7 2 3 5.2 Cc1c(CN2CCC(CO)(CCOc3ccccc3)CC2)[nH]c2c(Cl)cccc12 nan
CHEMBL1309448 20771 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 7 2 3 5.2 Cc1c(CN2CCC(CO)(CCOc3ccccc3)CC2)[nH]c2c(Cl)cccc12 nan
979811 20781 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 7 2 4 4.3 NS(=O)(=O)c1ccc(NCc2cc(Cl)ccc2OCc2ccccc2F)cc1 nan
CHEMBL1309498 20781 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 7 2 4 4.3 NS(=O)(=O)c1ccc(NCc2cc(Cl)ccc2OCc2ccccc2F)cc1 nan
16746354 20782 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 4 0 1 5.4 CC[C@@H]1CC=C[C@H]2[C@H]1C(=O)N(Cc1ccccc1)[C@H]2c1cc(C)ccc1F nan
CHEMBL1309499 20782 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 4 0 1 5.4 CC[C@@H]1CC=C[C@H]2[C@H]1C(=O)N(Cc1ccccc1)[C@H]2c1cc(C)ccc1F nan
902659 20793 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 4 1 3 5.5 O=C(Nc1ccc(Oc2ccc3ccccc3c2)cc1)c1ccco1 nan
CHEMBL1309620 20793 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 4 1 3 5.5 O=C(Nc1ccc(Oc2ccc3ccccc3c2)cc1)c1ccco1 nan
2816658 20802 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 1 6 3.8 CCOC(=O)c1c(N=C(S)N2CCCCC2)sc2c1CCN(C(=O)OCC)C2 nan
CHEMBL1309737 20802 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 1 6 3.8 CCOC(=O)c1c(N=C(S)N2CCCCC2)sc2c1CCN(C(=O)OCC)C2 nan
2957085 20810 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 325 2 0 6 3.0 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1nccs1 nan
CHEMBL1309785 20810 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 325 2 0 6 3.0 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1nccs1 nan
2908173 20826 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 291 1 0 3 3.6 CC1=CC2=C(OC1N(C)C)c1cccc3cccc(c13)C2=O nan
CHEMBL1309987 20826 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 291 1 0 3 3.6 CC1=CC2=C(OC1N(C)C)c1cccc3cccc(c13)C2=O nan
3942275 20836 None 9 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 497 5 1 7 4.6 CC1CN(S(=O)(=O)c2ccc(C(=O)Nc3nc(-c4cc5ccccc5o4)cs3)cc2)CC(C)O1 nan
CHEMBL1310132 20836 None 9 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 497 5 1 7 4.6 CC1CN(S(=O)(=O)c2ccc(C(=O)Nc3nc(-c4cc5ccccc5o4)cs3)cc2)CC(C)O1 nan
3237822 20848 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 7 4.6 Cc1ccccc1OCc1nc(-c2ccc(NC(=O)c3ccc4c(c3)OCO4)cc2)no1 nan
CHEMBL1310217 20848 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 7 4.6 Cc1ccccc1OCc1nc(-c2ccc(NC(=O)c3ccc4c(c3)OCO4)cc2)no1 nan
3620970 20850 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 8 0 7 2.8 CCCCCCn1c(CN2CCCCC2CC)nc2c1c(=O)n(C)c(=O)n2C nan
CHEMBL1310222 20850 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 8 0 7 2.8 CCCCCCn1c(CN2CCCCC2CC)nc2c1c(=O)n(C)c(=O)n2C nan
5525152 20851 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 6 0 5 6.1 COc1ccc(Oc2c(-c3ccc(OC)cc3)[s+]([O-])c3cc(OC)ccc23)cc1 nan
CHEMBL1310227 20851 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 6 0 5 6.1 COc1ccc(Oc2c(-c3ccc(OC)cc3)[s+]([O-])c3cc(OC)ccc23)cc1 nan
6518494 20854 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 2 2 2 5.4 Fc1cccc(/C=C2\CCCC3=C2N=C(S)NC3c2cccc(F)c2)c1 nan
CHEMBL1310240 20854 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 2 2 2 5.4 Fc1cccc(/C=C2\CCCC3=C2N=C(S)NC3c2cccc(F)c2)c1 nan
1831123 20856 None 5 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 3 1 7 5.2 Cc1nc2c(sc3nc(N4CCOCC4)c4c(c32)CC(C)(C)OC4)c(-c2ccccc2)c1C(=O)O nan
CHEMBL1310276 20856 None 5 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 3 1 7 5.2 Cc1nc2c(sc3nc(N4CCOCC4)c4c(c32)CC(C)(C)OC4)c(-c2ccccc2)c1C(=O)O nan
662882 20865 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 0 7 4.5 N#Cc1cc(Oc2cccc3cccnc23)c(-n2nnc3ccccc32)cc1C#N nan
CHEMBL1310319 20865 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 0 7 4.5 N#Cc1cc(Oc2cccc3cccnc23)c(-n2nnc3ccccc32)cc1C#N nan
2952839 20876 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 1 2 6 3.3 COc1cc2c3c(c1)C1(C(=O)N3C(C)(C)C=C2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
CHEMBL1310446 20876 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 1 2 6 3.3 COc1cc2c3c(c1)C1(C(=O)N3C(C)(C)C=C2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
4597240 20880 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 5 0 4 4.7 CN(C)c1oc(-c2ccccc2Cl)nc1P(=O)(c1ccccc1)c1ccccc1 nan
CHEMBL1310484 20880 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 5 0 4 4.7 CN(C)c1oc(-c2ccccc2Cl)nc1P(=O)(c1ccccc1)c1ccccc1 nan
5770965 20884 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 2 6 3.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)Cc2ccccc2OC)c(O)c1 nan
CHEMBL1310508 20884 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 2 6 3.6 COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)Cc2ccccc2OC)c(O)c1 nan
2328850 20888 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 326 2 0 2 5.2 c1ccc(CC2CCN(C3=Nc4cccc5cccc3c45)CC2)cc1 nan
CHEMBL1310527 20888 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 326 2 0 2 5.2 c1ccc(CC2CCN(C3=Nc4cccc5cccc3c45)CC2)cc1 nan
3851053 20889 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 0 7 2.9 CCOC(=O)C1CN(S(=O)(=O)c2cccc(C(F)(F)F)c2)c2cc(CC(=O)OC)ccc2O1 nan
CHEMBL1310531 20889 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 0 7 2.9 CCOC(=O)C1CN(S(=O)(=O)c2cccc(C(F)(F)F)c2)c2cc(CC(=O)OC)ccc2O1 nan
4163426 20892 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 9 0 7 4.0 CCCN(CCC)C(=O)CSc1nc2ccccc2c(=O)n1CC1COc2ccccc2O1 nan
CHEMBL1310543 20892 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 9 0 7 4.0 CCCN(CCC)C(=O)CSc1nc2ccccc2c(=O)n1CC1COc2ccccc2O1 nan
3929925 20897 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 7 1 7 4.6 CCC(CC)c1nnc(NC(=O)c2cc([N+](=O)[O-])ccc2N2CCCCC2)s1 nan
CHEMBL1310602 20897 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 7 1 7 4.6 CCC(CC)c1nnc(NC(=O)c2cc([N+](=O)[O-])ccc2N2CCCCC2)s1 nan
656336 20900 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 6 0 6 4.5 CCn1c(SCC(=O)c2ccc(Cl)cc2)nnc1-c1ccoc1C nan
CHEMBL1310609 20900 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 6 0 6 4.5 CCn1c(SCC(=O)c2ccc(Cl)cc2)nnc1-c1ccoc1C nan
647086 20902 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 7 2 4 3.2 CCOc1ccc(NC(=O)CN2CCC(NC(=O)C3CCCCC3)CC2)cc1 nan
CHEMBL1310630 20902 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 7 2 4 3.2 CCOc1ccc(NC(=O)CN2CCC(NC(=O)C3CCCCC3)CC2)cc1 nan
1299744 20907 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 1 6 4.3 COc1ccc(C(=O)Nc2cccc(-c3nnc(-c4ccco4)o3)c2)cc1 nan
CHEMBL1310660 20907 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 1 6 4.3 COc1ccc(C(=O)Nc2cccc(-c3nnc(-c4ccco4)o3)c2)cc1 nan
16745535 20910 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 897 7 9 16 1.1 CC1OC(O[C@H]2CC[C@]3(C)C4C=C[C@]56OC[C@@]7(CC[C@@H](C)[C@H](C)C75)[C@H](O)C[C@@]6(C)[C@]4(C)CC[C@H]3C2(C)C)C(OC2OC(CO)C(O)C(O)C2OC2OCC(O)C(O)C2O)C(O)C1O nan
CHEMBL1310664 20910 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 897 7 9 16 1.1 CC1OC(O[C@H]2CC[C@]3(C)C4C=C[C@]56OC[C@@]7(CC[C@@H](C)[C@H](C)C75)[C@H](O)C[C@@]6(C)[C@]4(C)CC[C@H]3C2(C)C)C(OC2OC(CO)C(O)C(O)C2OC2OCC(O)C(O)C2O)C(O)C1O nan
2299056 20927 None 8 Human Functional pPotency = 5 5.0 -3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 1 4 6.3 O=C(Nc1ccccc1Cl)c1ccccc1Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-] nan
CHEMBL1310804 20927 None 8 Human Functional pPotency = 5 5.0 -3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 5 1 4 6.3 O=C(Nc1ccccc1Cl)c1ccccc1Oc1ccc(C(F)(F)F)cc1[N+](=O)[O-] nan
3235905 20929 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 11 1 4 2.9 CCCCN(CCCNC(=O)C1CCN(S(=O)(=O)CC)CC1)c1ccccc1 nan
CHEMBL1310834 20929 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 11 1 4 2.9 CCCCN(CCCNC(=O)C1CCN(S(=O)(=O)CC)CC1)c1ccccc1 nan
734088 20944 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 6 1 4 3.7 CCOC(=O)c1cc(CC)sc1NC(=O)Cc1ccccc1 nan
CHEMBL1310977 20944 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 6 1 4 3.7 CCOC(=O)c1cc(CC)sc1NC(=O)Cc1ccccc1 nan
850121 20949 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 0 5 3.4 CCOc1ccc(C(C)(C)C)cc1S(=O)(=O)n1nc(C)cc1C nan
CHEMBL1311003 20949 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 4 0 5 3.4 CCOc1ccc(C(C)(C)C)cc1S(=O)(=O)n1nc(C)cc1C nan
16193265 20953 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 522 7 1 7 4.1 O=[N+]([O-])/C(C(=C(Cl)Cl)N1CCN(Cc2ccccc2)CC1)=C1\NCCN1Cc1ccc(Cl)nc1 nan
CHEMBL1311056 20953 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 522 7 1 7 4.1 O=[N+]([O-])/C(C(=C(Cl)Cl)N1CCN(Cc2ccccc2)CC1)=C1\NCCN1Cc1ccc(Cl)nc1 nan
2453271 20969 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 5 1 6 3.8 CCCCn1nc(C(=O)Nc2nc3c(s2)CCCC3)c2ccccc2c1=O nan
CHEMBL1311181 20969 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 5 1 6 3.8 CCCCn1nc(C(=O)Nc2nc3c(s2)CCCC3)c2ccccc2c1=O nan
2998084 20971 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 4.5 O=c1c2ccccc2nc(SCc2cn3ccsc3n2)n1-c1ccc(F)cc1 nan
CHEMBL1311188 20971 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 4.5 O=c1c2ccccc2nc(SCc2cn3ccsc3n2)n1-c1ccc(F)cc1 nan
1163207 20983 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 1 3 5.7 O=C(Nc1ccc(Cl)cc1)N(Cc1cccs1)Cc1cccs1 nan
CHEMBL1311324 20983 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 1 3 5.7 O=C(Nc1ccc(Cl)cc1)N(Cc1cccs1)Cc1cccs1 nan
2236064 20988 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 6 0 6 6.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(Cc1nc(-c2ccccc2)no1)C1CCCCC1 nan
CHEMBL1311353 20988 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 6 0 6 6.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(Cc1nc(-c2ccccc2)no1)C1CCCCC1 nan
652595 20990 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 8 1 7 4.5 CCn1c(CNc2ccccc2Cl)nnc1SCC(=O)OC1CCCCC1 nan
CHEMBL1311376 20990 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 8 1 7 4.5 CCn1c(CNc2ccccc2Cl)nnc1SCC(=O)OC1CCCCC1 nan
9510880 20996 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 1 3 5.3 CCN=c1ccc(Br)cc(C(=O)/C=C/c2c(Cl)cccc2Cl)c1O nan
CHEMBL1311453 20996 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 4 1 3 5.3 CCN=c1ccc(Br)cc(C(=O)/C=C/c2c(Cl)cccc2Cl)c1O nan
667293 21006 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 9 0 7 4.6 O=C(CSc1nnc(COc2ccccc2)n1Cc1ccco1)c1ccc(F)cc1 nan
CHEMBL1311514 21006 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 9 0 7 4.6 O=C(CSc1nnc(COc2ccccc2)n1Cc1ccco1)c1ccc(F)cc1 nan
1455001 21020 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 6 1 3 4.7 Cc1cc(C(C)(C)C)oc1C(=O)N(CC(=O)NC1CCCC1)Cc1ccc(F)cc1 nan
CHEMBL1311600 21020 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 6 1 3 4.7 Cc1cc(C(C)(C)C)oc1C(=O)N(CC(=O)NC1CCCC1)Cc1ccc(F)cc1 nan
892765 21038 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 4 1 2 4.7 CSc1cccc(NC(=O)/C=C/c2ccc(Cl)cc2)c1 nan
CHEMBL1311730 21038 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 4 1 2 4.7 CSc1cccc(NC(=O)/C=C/c2ccc(Cl)cc2)c1 nan
3662076 21052 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 0 4 5.3 O=c1cc(N2CCCCC2)c(-c2ccccc2)nn1Cc1ccc(Cl)cc1Cl nan
CHEMBL1311812 21052 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 0 4 5.3 O=c1cc(N2CCCCC2)c(-c2ccccc2)nn1Cc1ccc(Cl)cc1Cl nan
1474572 21055 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 1 5 4.3 Cc1cc(-c2ccccc2)nc(N(C)NC(=O)c2cccc(C(F)(F)F)c2)c1S(C)(=O)=O nan
CHEMBL1311828 21055 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 1 5 4.3 Cc1cc(-c2ccccc2)nc(N(C)NC(=O)c2cccc(C(F)(F)F)c2)c1S(C)(=O)=O nan
645843 21088 None 3 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 10 0 9 2.7 CCCCCCN(Cc1ccco1)c1nc(N2CCOCC2)nc(N2CCOCC2)n1 nan
CHEMBL1312094 21088 None 3 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 10 0 9 2.7 CCCCCCN(Cc1ccco1)c1nc(N2CCOCC2)nc(N2CCOCC2)n1 nan
990753 21099 None 6 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 3 0 5 4.6 COC(=O)c1cc2c(-c3ccccc3)c(C)c3ccccn3c-2c1C(=O)OC nan
CHEMBL1312189 21099 None 6 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 3 0 5 4.6 COC(=O)c1cc2c(-c3ccccc3)c(C)c3ccccn3c-2c1C(=O)OC nan
5738082 21104 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 2 4 4.0 CC1=C(C(=O)OCc2ccccc2)C(/C=C/c2ccccc2)NC(S)=N1 nan
CHEMBL1312208 21104 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 2 4 4.0 CC1=C(C(=O)OCc2ccccc2)C(/C=C/c2ccccc2)NC(S)=N1 nan
1820255 21105 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 2 4 3.9 O=C(O)/C=C\C(=O)Nc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 nan
CHEMBL1312214 21105 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 2 4 3.9 O=C(O)/C=C\C(=O)Nc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 nan
1815226 21110 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 7 0 5 3.5 CCCCN1C(=O)/C(=C/c2ccc(N(C)C)cc2)C(=O)N(Cc2ccco2)C1=O nan
CHEMBL1312235 21110 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 7 0 5 3.5 CCCCN1C(=O)/C(=C/c2ccc(N(C)C)cc2)C(=O)N(Cc2ccco2)C1=O nan
647458 21116 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 7 1 5 4.9 CCOc1ccc2nc(O)c(CN(Cc3ccc(F)cc3)C(=O)c3ccco3)cc2c1 nan
CHEMBL1312261 21116 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 420 7 1 5 4.9 CCOc1ccc2nc(O)c(CN(Cc3ccc(F)cc3)C(=O)c3ccco3)cc2c1 nan
3572262 21118 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 4 4.5 O=C(Cc1cccs1)N(CC1CCCO1)C1(C(=O)NC2CCCCC2)CCCCC1 nan
CHEMBL1312278 21118 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 7 1 4 4.5 O=C(Cc1cccs1)N(CC1CCCO1)C1(C(=O)NC2CCCCC2)CCCCC1 nan
1232742 21163 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 6 0 4 4.8 O=C(COc1ccc(Cl)cc1Cl)N1CCCN(C(=O)COc2ccc(Cl)cc2Cl)CC1 nan
CHEMBL1312619 21163 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 6 0 4 4.8 O=C(COc1ccc(Cl)cc1Cl)N1CCCN(C(=O)COc2ccc(Cl)cc2Cl)CC1 nan
245581 21183 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 230 2 0 4 2.5 N#CC(C#N)=Cc1ccc(C=C(C#N)C#N)cc1 nan
CHEMBL1312723 21183 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 230 2 0 4 2.5 N#CC(C#N)=Cc1ccc(C=C(C#N)C#N)cc1 nan
16189120 21191 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 4 0 5 4.0 O=C(c1ccc(Cl)cc1)C1CCCN(Cc2ccc3nonc3c2)C1 nan
CHEMBL1312769 21191 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 4 0 5 4.0 O=C(c1ccc(Cl)cc1)C1CCCN(Cc2ccc3nonc3c2)C1 nan
4655733 21192 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 9 1 7 3.9 CCCCn1c(SC(C)C(=O)c2ccc(OC)cc2)nc2cc(S(N)(=O)=O)ccc21 nan
CHEMBL1312774 21192 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 9 1 7 3.9 CCCCn1c(SC(C)C(=O)c2ccc(OC)cc2)nc2cc(S(N)(=O)=O)ccc21 nan
1114757 21193 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 5 2 8 5.2 Cc1ccccc1Nc1nc(Nc2ccccc2C)nc(SC2=NCCS2)n1 nan
CHEMBL1312783 21193 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 5 2 8 5.2 Cc1ccccc1Nc1nc(Nc2ccccc2C)nc(SC2=NCCS2)n1 nan
1715236 21194 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 4 0 2 3.9 Cc1ccc(C(=O)/C=C\C(=O)c2ccc(C)cc2)cc1 nan
CHEMBL1312788 21194 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 4 0 2 3.9 Cc1ccc(C(=O)/C=C\C(=O)c2ccc(C)cc2)cc1 nan
16187184 21205 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 572 9 1 7 4.0 O=C(C1=C[C@H](c2ccc(Br)cc2)C[C@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
CHEMBL1312906 21205 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 572 9 1 7 4.0 O=C(C1=C[C@H](c2ccc(Br)cc2)C[C@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
647611 21213 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 8 1 8 4.0 CCC(C)(C)n1nnnc1CN(Cc1cc2cc(OC)ccc2nc1O)C1CCCC1 nan
CHEMBL1312972 21213 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 8 1 8 4.0 CCC(C)(C)n1nnnc1CN(Cc1cc2cc(OC)ccc2nc1O)C1CCCC1 nan
2828497 21216 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 0 3 6.1 CCCCN1C2=C(C(=O)CC(C)(C)C2)C(c2ccccc2)C2=C1c1ccccc1C2=O nan
CHEMBL1312984 21216 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 0 3 6.1 CCCCN1C2=C(C(=O)CC(C)(C)C2)C(c2ccccc2)C2=C1c1ccccc1C2=O nan
16193030 21219 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 11 1 7 6.1 CCOC(=O)c1ccc(NC(c2ccc(N(C)C)cc2)P(=O)(OC(C)C)OC(C)C)cc1 nan
CHEMBL1312995 21219 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 11 1 7 6.1 CCOC(=O)c1ccc(NC(c2ccc(N(C)C)cc2)P(=O)(OC(C)C)OC(C)C)cc1 nan
2213077 21221 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 1 8 3.9 Cc1ccc(-c2csc3nnc(SCC(=O)NCc4ccc5c(c4)OCO5)n23)cc1 nan
CHEMBL1313004 21221 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 1 8 3.9 Cc1ccc(-c2csc3nnc(SCC(=O)NCc4ccc5c(c4)OCO5)n23)cc1 nan
780661 21228 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 1 8 2.2 CCOC(=O)c1cnn(-c2ncnc3sc(CC)cc23)c1N nan
CHEMBL1313045 21228 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 1 8 2.2 CCOC(=O)c1cnn(-c2ncnc3sc(CC)cc23)c1N nan
3096982 21232 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 1 4 3.8 CCO/C(O)=C1\C(C)=NC(=S)N(C(C)=O)C1c1ccc(Cl)cc1 nan
CHEMBL1313081 21232 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 1 4 3.8 CCO/C(O)=C1\C(C)=NC(=S)N(C(C)=O)C1c1ccc(Cl)cc1 nan
1244132 21236 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 4 1 5 4.2 CCc1cc(C(=O)OC)c(NC(=O)c2cc(Br)cs2)s1 nan
CHEMBL1313122 21236 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 4 1 5 4.2 CCc1cc(C(=O)OC)c(NC(=O)c2cc(Br)cs2)s1 nan
3240372 21238 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 5 3 4 4.5 CCCc1ccc(Oc2c[nH]nc2-c2ccc(O)c(C)c2O)cc1 nan
CHEMBL1313141 21238 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 5 3 4 4.5 CCCc1ccc(Oc2c[nH]nc2-c2ccc(O)c(C)c2O)cc1 nan
1249699 21254 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 3 1 6 4.0 Cc1cc(NC(=O)c2cnn3c(C(F)(F)F)cc(-c4ccccc4)nc23)no1 nan
CHEMBL1313249 21254 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 3 1 6 4.0 Cc1cc(NC(=O)c2cnn3c(C(F)(F)F)cc(-c4ccccc4)nc23)no1 nan
1266325 21255 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 7 1 7 3.6 Cc1ccc(CNC(=O)CSc2nc(N3CCCCC3)nc(N3CCCCC3)n2)cc1 nan
CHEMBL1313253 21255 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 7 1 7 3.6 Cc1ccc(CNC(=O)CSc2nc(N3CCCCC3)nc(N3CCCCC3)n2)cc1 nan
1475530 21263 None 17 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 6 1 5 5.0 CNc1cc(CSC)nc(SCc2ccc(Cl)c(Cl)c2)n1 nan
CHEMBL1313321 21263 None 17 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 6 1 5 5.0 CNc1cc(CSC)nc(SCc2ccc(Cl)c(Cl)c2)n1 nan
1033407 21270 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 4 1 4 4.0 CC(=O)Nc1sc2c(c1CN1CCN(c3ccc(F)cc3)CC1)CCCC2 nan
CHEMBL1313417 21270 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 4 1 4 4.0 CC(=O)Nc1sc2c(c1CN1CCN(c3ccc(F)cc3)CC1)CCCC2 nan
2437346 21277 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 7 1 6 3.7 COc1ccccc1/C=C/C(=O)OCC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1 nan
CHEMBL1313456 21277 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 7 1 6 3.7 COc1ccccc1/C=C/C(=O)OCC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1 nan
3151818 21283 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 2 4 3.5 Cc1ccc(N=C(N)Nc2nc(C)cc(N3CCCCC3)n2)c(C)c1 nan
5768753 21283 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 2 4 3.5 Cc1ccc(N=C(N)Nc2nc(C)cc(N3CCCCC3)n2)c(C)c1 nan
9595162 21283 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 2 4 3.5 Cc1ccc(N=C(N)Nc2nc(C)cc(N3CCCCC3)n2)c(C)c1 nan
CHEMBL1313502 21283 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 2 4 3.5 Cc1ccc(N=C(N)Nc2nc(C)cc(N3CCCCC3)n2)c(C)c1 nan
3719872 21285 None 12 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 4 1 6 3.8 Cc1cc(N2C(=O)C(O)=C(C(=O)c3cccs3)C2c2ccccc2)no1 nan
CHEMBL1313510 21285 None 12 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 4 1 6 3.8 Cc1cc(N2C(=O)C(O)=C(C(=O)c3cccs3)C2c2ccccc2)no1 nan
736468 21296 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 217 0 1 3 0.6 Nc1cccc2c1=NC1(CCCCC1)[N+]=2[O-] nan
CHEMBL1313583 21296 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 217 0 1 3 0.6 Nc1cccc2c1=NC1(CCCCC1)[N+]=2[O-] nan
3775722 21306 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 6 2 4 5.0 O=C(NNC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1313653 21306 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 6 2 4 5.0 O=C(NNC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)c1ccc(Cl)c(Cl)c1 nan
6407317 21311 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 5 1 5 6.0 COc1ccc(Nc2nnc(-c3ccc(C)cc3)c3ccccc23)cc1C(=O)N1CCCCC1 nan
CHEMBL1313679 21311 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 5 1 5 6.0 COc1ccc(Nc2nnc(-c3ccc(C)cc3)c3ccccc23)cc1C(=O)N1CCCCC1 nan
2197541 21316 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 6 4.3 CC(C)c1ccc(-c2c(C#N)c(N)nc(SCC(=O)N3CCCCC3)c2C#N)cc1 nan
CHEMBL1313695 21316 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 6 4.3 CC(C)c1ccc(-c2c(C#N)c(N)nc(SCC(=O)N3CCCCC3)c2C#N)cc1 nan
651221 21329 None 2 Human Functional pPotency = 5 5.0 -10 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 6 0 6 3.8 CC(C)CC(c1nnnn1C(C)C)N1CCN(c2cccc(Cl)c2)CC1 nan
CHEMBL1313855 21329 None 2 Human Functional pPotency = 5 5.0 -10 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 6 0 6 3.8 CC(C)CC(c1nnnn1C(C)C)N1CCN(c2cccc(Cl)c2)CC1 nan
4119285 21488 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 2 0 7 2.2 Cn1/c(=N/C(=O)c2ccc3c(c2)OCCO3)sc2cc(S(C)(=O)=O)ccc21 nan
CHEMBL1315733 21488 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 2 0 7 2.2 Cn1/c(=N/C(=O)c2ccc3c(c2)OCCO3)sc2cc(S(C)(=O)=O)ccc21 nan
901696 21737 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 4 0 5 4.5 COc1cccc(-c2cnc(OC(C)(C)C)nc2OC(C)(C)C)c1 nan
CHEMBL1318768 21737 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 4 0 5 4.5 COc1cccc(-c2cnc(OC(C)(C)C)nc2OC(C)(C)C)c1 nan
3245692 21750 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 4 1 6 2.3 c1ccc(CCNc2nc3ccccc3n3nnnc23)cc1 nan
CHEMBL1318873 21750 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 4 1 6 2.3 c1ccc(CCNc2nc3ccccc3n3nnnc23)cc1 nan
657546 21759 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 293 2 1 3 2.7 [O-][N+]1=c2ccc(Nc3ccccc3)cc2=NC12CCCCC2 nan
CHEMBL1318943 21759 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 293 2 1 3 2.7 [O-][N+]1=c2ccc(Nc3ccccc3)cc2=NC12CCCCC2 nan
6413140 21765 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 5 0 5 4.3 Cc1cccc(OCC(=O)N2CCN(c3nnc(-c4ccccc4)c4ccccc34)CC2)c1 nan
CHEMBL1318969 21765 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 5 0 5 4.3 Cc1cccc(OCC(=O)N2CCN(c3nnc(-c4ccccc4)c4ccccc34)CC2)c1 nan
16746578 21766 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 472 10 3 7 2.4 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 nan
CHEMBL1318970 21766 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 472 10 3 7 2.4 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 nan
9550154 21769 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 7 0 7 5.9 COc1ccc(-c2nc(Cn3c(SCc4ccccc4F)nc4ccncc43)c(C)o2)cc1 nan
CHEMBL1318981 21769 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 7 0 7 5.9 COc1ccc(-c2nc(Cn3c(SCc4ccccc4F)nc4ccncc43)c(C)o2)cc1 nan
4594162 21786 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 2 0 4 5.2 O=C(c1cccc(C(F)(F)F)c1)N1CCOC12CCN(c1ncc(C(F)(F)F)cc1Cl)CC2 nan
CHEMBL1319186 21786 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 2 0 4 5.2 O=C(c1cccc(C(F)(F)F)c1)N1CCOC12CCN(c1ncc(C(F)(F)F)cc1Cl)CC2 nan
1954978 21788 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 3 0 6 3.9 Cc1ccc(-c2nc3c(c(=O)c4ccccc4n3C)c(=O)n2Cc2ccco2)cc1 nan
CHEMBL1319191 21788 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 3 0 6 3.9 Cc1ccc(-c2nc3c(c(=O)c4ccccc4n3C)c(=O)n2Cc2ccco2)cc1 nan
3166012 21796 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 7 1 3 3.7 O=C(CN1CCN(C(c2ccccc2)c2ccccc2)CC1)NCc1ccccc1 nan
CHEMBL1319252 21796 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 7 1 3 3.7 O=C(CN1CCN(C(c2ccccc2)c2ccccc2)CC1)NCc1ccccc1 nan
2997866 21799 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 9 0 7 4.9 O=C(CCCSc1nnc(-c2cccs2)n1CC1CCCO1)c1ccccc1 nan
CHEMBL1319284 21799 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 9 0 7 4.9 O=C(CCCSc1nnc(-c2cccs2)n1CC1CCCO1)c1ccccc1 nan
4576746 21816 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 4 0 5 5.4 O=C(c1cc(Sc2cccc(Cl)c2)nc2ccccc12)N1CCN(c2ccccn2)CC1 nan
CHEMBL1319420 21816 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 4 0 5 5.4 O=C(c1cc(Sc2cccc(Cl)c2)nc2ccccc12)N1CCN(c2ccccn2)CC1 nan
900914 21839 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 319 2 0 3 5.0 Cc1nn2c(-c3ccc(Cl)cc3)ccnc2c1-c1ccccc1 nan
CHEMBL1319589 21839 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 319 2 0 3 5.0 Cc1nn2c(-c3ccc(Cl)cc3)ccnc2c1-c1ccccc1 nan
1154664 21843 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 5 1 5 4.5 CCOC(=O)c1cc(C(C)(C)C)oc1CNC(=O)c1c(C)oc2c1CCCC2 nan
CHEMBL1319661 21843 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 5 1 5 4.5 CCOC(=O)c1cc(C(C)(C)C)oc1CNC(=O)c1c(C)oc2c1CCCC2 nan
1374557 21848 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 2 2 6 5.1 Cc1sc(NC(=O)c2sc3nc4c(C)cccc4cc3c2N)c(C#N)c1C nan
CHEMBL1319682 21848 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 2 2 6 5.1 Cc1sc(NC(=O)c2sc3nc4c(C)cccc4cc3c2N)c(C#N)c1C nan
3947072 21866 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 6 3.2 CCN(C(=O)COC(=O)c1ccccc1Nc1cccc(C)c1C)C1CCS(=O)(=O)C1 nan
CHEMBL1319812 21866 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 6 3.2 CCN(C(=O)COC(=O)c1ccccc1Nc1cccc(C)c1C)C1CCS(=O)(=O)C1 nan
2868128 21887 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 3 1 4 6.5 CCOc1ccc(C2Nc3ccc4ccccc4c3-c3c2c(=O)oc2ccccc32)cc1 nan
CHEMBL1320026 21887 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 3 1 4 6.5 CCOc1ccc(C2Nc3ccc4ccccc4c3-c3c2c(=O)oc2ccccc32)cc1 nan
662088 21893 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 6 0 8 2.8 COC(=O)C1CCN(c2nc3ccccc3nc2C(C#N)C(=O)OCC(C)C)CC1 nan
CHEMBL1320071 21893 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 6 0 8 2.8 COC(=O)C1CCN(c2nc3ccccc3nc2C(C#N)C(=O)OCC(C)C)CC1 nan
3112173 21903 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 1 0 3 5.4 CC1(C)CC(=O)C2=C(C1)N=C1c3ccccc3C(=O)C1C2c1ccc(Cl)cc1 nan
CHEMBL1320170 21903 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 1 0 3 5.4 CC1(C)CC(=O)C2=C(C1)N=C1c3ccccc3C(=O)C1C2c1ccc(Cl)cc1 nan
3167480 21909 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 4 1 6 5.1 Cc1ccc2nc(SCC(=O)Nc3ccc4sc(C)nc4c3)c(C#N)cc2c1 nan
CHEMBL1320193 21909 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 4 1 6 5.1 Cc1ccc2nc(SCC(=O)Nc3ccc4sc(C)nc4c3)c(C#N)cc2c1 nan
2998707 21910 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 4.5 O=c1c2ccccc2nc(SCc2cn3ccsc3n2)n1-c1ccccc1F nan
CHEMBL1320203 21910 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 4.5 O=c1c2ccccc2nc(SCc2cn3ccsc3n2)n1-c1ccccc1F nan
2947277 21914 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 2 1 3 5.7 CC1=Nc2ccccc2N=C(NC(=O)c2ccccc2)C1c1ccc(Cl)cc1 nan
CHEMBL1320250 21914 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 2 1 3 5.7 CC1=Nc2ccccc2N=C(NC(=O)c2ccccc2)C1c1ccc(Cl)cc1 nan
3152151 21922 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 418 6 1 3 4.0 Cc1cc(C)c(S(=O)(=O)N2CCCC(C(=O)NCCC3=CCCCC3)C2)c(C)c1 nan
CHEMBL1320305 21922 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 418 6 1 3 4.0 Cc1cc(C)c(S(=O)(=O)N2CCCC(C(=O)NCCC3=CCCCC3)C2)c(C)c1 nan
24867532 21923 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 1 0 5 4.9 CC(=O)SC1CC2=CC(=O)CC[C@]2(C)C2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)C12 nan
CHEMBL1320310 21923 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 1 0 5 4.9 CC(=O)SC1CC2=CC(=O)CC[C@]2(C)C2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)C12 nan
2961258 21925 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 6 1 7 4.8 O=C(CSc1nnc(C23CC4CC(CC(C4)C2)C3)o1)Nc1ccc(N2CCOCC2)c(Cl)c1 nan
CHEMBL1320327 21925 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 6 1 7 4.8 O=C(CSc1nnc(C23CC4CC(CC(C4)C2)C3)o1)Nc1ccc(N2CCOCC2)c(Cl)c1 nan
2429522 21927 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 0 9 2.1 Cc1ccc(-n2nnnc2SCn2nnc3ccccc3c2=O)c(C)c1 nan
CHEMBL1320353 21927 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 0 9 2.1 Cc1ccc(-n2nnnc2SCn2nnc3ccccc3c2=O)c(C)c1 nan
2116743 21929 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 1 5 3.6 O=C(Nc1ccccc1Cl)c1cc(S(=O)(=O)N2CCCCC2)ccc1N1CCOCC1 nan
CHEMBL1320364 21929 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 1 5 3.6 O=C(Nc1ccccc1Cl)c1cc(S(=O)(=O)N2CCCCC2)ccc1N1CCOCC1 nan
2081690 21939 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 5 2 4 4.3 CN(c1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2nc3ccccc3[nH]2)ccc1Cl nan
CHEMBL1320446 21939 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 5 2 4 4.3 CN(c1ccccc1)S(=O)(=O)c1cc(C(=O)Nc2nc3ccccc3[nH]2)ccc1Cl nan
754790 21940 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 258 1 1 4 2.9 Cc1cc(N)n2ncc(-c3ccc(Cl)cc3)c2n1 nan
CHEMBL1320453 21940 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 258 1 1 4 2.9 Cc1cc(N)n2ncc(-c3ccc(Cl)cc3)c2n1 nan
665767 21946 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 3 0 6 4.6 Cc1nn2c(N3CCN(C(=O)c4ccco4)CC3)cc(C(C)(C)C)nc2c1-c1ccccc1 nan
CHEMBL1320506 21946 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 3 0 6 4.6 Cc1nn2c(N3CCN(C(=O)c4ccco4)CC3)cc(C(C)(C)C)nc2c1-c1ccccc1 nan
5111869 21950 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 4 1 6 3.6 O=C(Nc1cccc(S(=O)(=O)N2CCCCC2)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
CHEMBL1320541 21950 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 4 1 6 3.6 O=C(Nc1cccc(S(=O)(=O)N2CCCCC2)c1)c1ccc2c(=O)n3c(nc2c1)CCCCC3 nan
16060474 21952 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 1 6.7 C[C@@]12CCC=C[C@H]1[C@H](c1ccc3ccccc3c1Br)N(Cc1ccccc1)C2=O nan
CHEMBL1320562 21952 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 1 6.7 C[C@@]12CCC=C[C@H]1[C@H](c1ccc3ccccc3c1Br)N(Cc1ccccc1)C2=O nan
655615 21957 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 278 5 1 6 1.4 Cn1c(SCC(=O)NC2CC2)nnc1-c1ccco1 nan
CHEMBL1320597 21957 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 278 5 1 6 1.4 Cn1c(SCC(=O)NC2CC2)nnc1-c1ccco1 nan
660374 21962 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 8 0 8 2.7 COCCOC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1320632 21962 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 8 0 8 2.7 COCCOC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
1048122 21996 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 4 2 3 4.4 O=C(NC(=S)Nc1ccc(Cl)cn1)C(c1ccccc1)c1ccccc1 nan
CHEMBL1320940 21996 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 4 2 3 4.4 O=C(NC(=S)Nc1ccc(Cl)cn1)C(c1ccccc1)c1ccccc1 nan
3236218 22007 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 5 0 6 3.7 CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4CCCCCC4)cc3c2C)CC1 nan
CHEMBL1321018 22007 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 5 0 6 3.7 CCOC(=O)C1CCN(C(=O)c2oc3ccc(S(=O)(=O)N4CCCCCC4)cc3c2C)CC1 nan
3178104 22019 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 553 8 2 6 5.3 O=C(NC1CCCC1)C(c1c[nH]c2ccccc12)N(C(=O)Cn1nnc(-c2ccc(Cl)cc2)n1)c1ccccc1 nan
CHEMBL1321136 22019 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 553 8 2 6 5.3 O=C(NC1CCCC1)C(c1c[nH]c2ccccc12)N(C(=O)Cn1nnc(-c2ccc(Cl)cc2)n1)c1ccccc1 nan
4183437 22080 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 3 0 5 4.4 COc1ccccc1-c1c(C)nn2c(N3CCCCCC3)cc(C)nc12 nan
CHEMBL1321713 22080 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 3 0 5 4.4 COc1ccccc1-c1c(C)nn2c(N3CCCCCC3)cc(C)nc12 nan
655644 22114 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 9 1 7 4.8 COc1ccccc1NC(=O)CSc1nnc(-c2ccoc2C)n1CCc1ccccc1 nan
CHEMBL1322017 22114 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 9 1 7 4.8 COc1ccccc1NC(=O)CSc1nnc(-c2ccoc2C)n1CCc1ccccc1 nan
16187231 22117 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 0 6 4.3 Cc1ccc(-c2nn(-c3cccc(F)c3)cc2CN2CCN(c3ccccn3)CC2)o1 nan
CHEMBL1322028 22117 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 0 6 4.3 Cc1ccc(-c2nn(-c3cccc(F)c3)cc2CN2CCN(c3ccccn3)CC2)o1 nan
2829026 22119 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 530 4 0 8 3.3 O=C(OCc1ccccc1)N1CCOCCOCCN(C(=O)OCc2ccccc2)CCOCCOCC1 nan
CHEMBL1322032 22119 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 530 4 0 8 3.3 O=C(OCc1ccccc1)N1CCOCCOCCN(C(=O)OCc2ccccc2)CCOCCOCC1 nan
16746268 22134 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 574 11 0 9 5.2 COc1cc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3ccc(=O)oc23)cc(OC)c1OC nan
CHEMBL1322163 22134 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 574 11 0 9 5.2 COc1cc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3ccc(=O)oc23)cc(OC)c1OC nan
1086433 22162 None 16 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 4 0 5 4.9 N#Cc1c(C(F)(F)F)cc(-c2ccco2)nc1SCc1ccccn1 nan
CHEMBL1322401 22162 None 16 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 4 0 5 4.9 N#Cc1c(C(F)(F)F)cc(-c2ccco2)nc1SCc1ccccn1 nan
5309987 22163 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 3.2 CC(C)c1nc(SCc2c(F)cccc2Cl)c2c(=O)n(C)c(=O)n(C)c2n1 nan
CHEMBL1322422 22163 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 7 3.2 CC(C)c1nc(SCc2c(F)cccc2Cl)c2c(=O)n(C)c(=O)n(C)c2n1 nan
16196991 22174 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 9 2 5 5.0 CCO[C@@H]1OC(C(=O)NCc2ccccc2)=C[C@H](c2csc3ccccc23)[C@H]1CCCO nan
CHEMBL1322509 22174 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 9 2 5 5.0 CCO[C@@H]1OC(C(=O)NCc2ccccc2)=C[C@H](c2csc3ccccc23)[C@H]1CCCO nan
2951236 22190 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 5 0 4 3.9 COc1ccc(N2CCN(C(=O)C(C)(C)Oc3ccc(Cl)cc3)CC2)cc1 nan
CHEMBL1322656 22190 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 5 0 4 3.9 COc1ccc(N2CCN(C(=O)C(C)(C)Oc3ccc(Cl)cc3)CC2)cc1 nan
1045636 22214 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 5 1 9 3.5 N#Cc1c(C(F)(F)F)cc(-c2ccccc2)nc1SCc1nc(N)nc(N2CCOCC2)n1 nan
CHEMBL1322881 22214 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 5 1 9 3.5 N#Cc1c(C(F)(F)F)cc(-c2ccccc2)nc1SCc1nc(N)nc(N2CCOCC2)n1 nan
14925591 22219 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 1 0 1 4.2 CN1C=C/C(=C/c2ccc3ccccc3[n+]2C)c2ccccc21 nan
35580865 22219 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 1 0 1 4.2 CN1C=C/C(=C/c2ccc3ccccc3[n+]2C)c2ccccc21 nan
44355085 22219 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 1 0 1 4.2 CN1C=C/C(=C/c2ccc3ccccc3[n+]2C)c2ccccc21 nan
CHEMBL132294 22219 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 1 0 1 4.2 CN1C=C/C(=C/c2ccc3ccccc3[n+]2C)c2ccccc21 nan
CHEMBL1342894 22219 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 299 1 0 1 4.2 CN1C=C/C(=C/c2ccc3ccccc3[n+]2C)c2ccccc21 nan
1912891 22246 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 5 2 6 3.7 Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1Cc1ccccc1 nan
CHEMBL1323252 22246 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 5 2 6 3.7 Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1Cc1ccccc1 nan
5337233 22277 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 4 3 4 3.5 Cc1ccc(C(=O)N/C(=C\c2ccccc2F)c2n[nH]c(S)n2)cc1 nan
CHEMBL1323544 22277 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 354 4 3 4 3.5 Cc1ccc(C(=O)N/C(=C\c2ccccc2F)c2n[nH]c(S)n2)cc1 nan
644442 22281 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 1 5 2.8 O=S(=O)(Nc1cccc2cccnc12)c1ccc(S(=O)(=O)N2CCCC2)cc1 nan
CHEMBL1323553 22281 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 1 5 2.8 O=S(=O)(Nc1cccc2cccnc12)c1ccc(S(=O)(=O)N2CCCC2)cc1 nan
2562953 22290 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 8 2 4 4.5 COc1ccc(Cl)cc1NC(=O)CN(C)CC(=O)Nc1ccccc1-c1ccccc1 nan
CHEMBL1323627 22290 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 8 2 4 4.5 COc1ccc(Cl)cc1NC(=O)CN(C)CC(=O)Nc1ccccc1-c1ccccc1 nan
2477200 22298 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 3 1 3 3.9 O=S(=O)(c1ccc2ccccc2c1)N1CCN(C(S)=Nc2ccccc2F)CC1 nan
CHEMBL1323707 22298 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 3 1 3 3.9 O=S(=O)(c1ccc2ccccc2c1)N1CCN(C(S)=Nc2ccccc2F)CC1 nan
2767412 22300 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 8 0 7 4.2 CCOC(=O)C(C)Sc1cc(CS(=O)(=O)c2ccccc2)nc(-c2ccccc2)n1 nan
CHEMBL1323725 22300 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 8 0 7 4.2 CCOC(=O)C(C)Sc1cc(CS(=O)(=O)c2ccccc2)nc(-c2ccccc2)n1 nan
3224046 22301 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 6 2 2 4.9 Cc1cc2nc(CCN(C(S)=NCC(C)C)C3CCCC3)[nH]c2cc1C nan
CHEMBL1323732 22301 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 6 2 2 4.9 Cc1cc2nc(CCN(C(S)=NCC(C)C)C3CCCC3)[nH]c2cc1C nan
2959710 22307 None 10 Human Functional pPotency = 5 5.0 -10 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 4 2 3 3.4 O=C(CC12CC3CC(CC(C3)C1)C2)NC(=S)NCc1ccco1 nan
CHEMBL1323770 22307 None 10 Human Functional pPotency = 5 5.0 -10 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 4 2 3 3.4 O=C(CC12CC3CC(CC(C3)C1)C2)NC(=S)NCc1ccco1 nan
5713290 22345 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 3 0 3 5.1 COc1ccc(/C=C2\C(=O)c3ccccc3OC2c2ccccc2)cc1 nan
CHEMBL1324044 22345 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 3 0 3 5.1 COc1ccc(/C=C2\C(=O)c3ccccc3OC2c2ccccc2)cc1 nan
1007622 22349 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 3 0 2 5.2 CC1CCN(C(=S)c2cn(Cc3ccccc3F)c3ccccc23)CC1 nan
CHEMBL1324077 22349 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 3 0 2 5.2 CC1CCN(C(=S)c2cn(Cc3ccccc3F)c3ccccc23)CC1 nan
2871813 22357 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 0 5 4.0 N#Cc1c(SCc2ccccc2)nc(N2CCOCC2)c2c1CCCC2 nan
CHEMBL1324121 22357 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 365 4 0 5 4.0 N#Cc1c(SCc2ccccc2)nc(N2CCOCC2)c2c1CCCC2 nan
1115184 22367 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 5 1 7 3.8 CCOc1ccc(-n2nc3ccc(NC(=O)c4ccc5c(c4)OCCO5)cc3n2)cc1 nan
CHEMBL1324224 22367 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 5 1 7 3.8 CCOc1ccc(-n2nc3ccc(NC(=O)c4ccc5c(c4)OCCO5)cc3n2)cc1 nan
6076700 22369 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 10 2 7 2.1 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CCOCCO)C2c2cccnc2)cc1 nan
CHEMBL1324242 22369 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 10 2 7 2.1 CCOc1ccc(C(=O)C2=C(O)C(=O)N(CCOCCO)C2c2cccnc2)cc1 nan
2220749 22372 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 3 1 3 6.3 O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(-c2cccnc2)nc2ccc(Br)cc12 nan
CHEMBL1324256 22372 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 3 1 3 6.3 O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(-c2cccnc2)nc2ccc(Br)cc12 nan
4302597 22375 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 323 2 1 6 3.1 Cc1c(Cl)c(-c2nnc(S)n2-c2ccc(F)cc2)nn1C nan
CHEMBL1324305 22375 None 10 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 323 2 1 6 3.1 Cc1c(Cl)c(-c2nnc(S)n2-c2ccc(F)cc2)nn1C nan
646026 22414 None 3 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 9 0 8 3.4 CCCC(c1nnnn1Cc1ccc(OC)cc1)N1CCN(c2ccccc2OC)CC1 nan
CHEMBL1324598 22414 None 3 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 9 0 8 3.4 CCCC(c1nnnn1Cc1ccc(OC)cc1)N1CCN(c2ccccc2OC)CC1 nan
651405 22421 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 3 0 3 5.0 O=C(c1cc2sccc2n1Cc1ccccc1)N1CCc2ccccc21 nan
CHEMBL1324684 22421 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 3 0 3 5.0 O=C(c1cc2sccc2n1Cc1ccccc1)N1CCc2ccccc21 nan
2459999 22423 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 6 0 5 5.1 Cc1onc(-c2ccccc2)c1C(=O)N(Cc1ccco1)Cc1cccs1 nan
CHEMBL1324698 22423 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 6 0 5 5.1 Cc1onc(-c2ccccc2)c1C(=O)N(Cc1ccco1)Cc1cccs1 nan
822356 22447 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 4 0 2 4.6 O=S(=O)(C=C(c1ccccc1)c1ccccc1)c1ccccc1 nan
CHEMBL1324866 22447 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 4 0 2 4.6 O=S(=O)(C=C(c1ccccc1)c1ccccc1)c1ccccc1 nan
9550444 22451 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 6 0 5 4.4 Cc1cc(C)cc(N(CC(=O)N2CC=C(c3ccccc3)CC2)S(=O)(=O)c2c(C)noc2C)c1 nan
CHEMBL1324941 22451 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 6 0 5 4.4 Cc1cc(C)cc(N(CC(=O)N2CC=C(c3ccccc3)CC2)S(=O)(=O)c2c(C)noc2C)c1 nan
16682195 22454 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 7 2 6 4.5 CC(C)c1cc(-c2cc(C(=O)NCc3ccccc3)on2)nc(NC2CCCC2)n1 nan
CHEMBL1324958 22454 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 7 2 6 4.5 CC(C)c1cc(-c2cc(C(=O)NCc3ccccc3)on2)nc(NC2CCCC2)n1 nan
1548076 22461 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 288 2 0 2 4.9 c1ccc(-c2ccc(-c3cnc4n3CCCCC4)cc2)cc1 nan
CHEMBL1324988 22461 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 288 2 0 2 4.9 c1ccc(-c2ccc(-c3cnc4n3CCCCC4)cc2)cc1 nan
3244680 22468 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 8 1 7 3.5 COc1ccc(OC)c(NC(=O)CN(c2ccc(C)cc2)S(=O)(=O)c2c(C)noc2C)c1 nan
CHEMBL1325054 22468 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 8 1 7 3.5 COc1ccc(OC)c(NC(=O)CN(c2ccc(C)cc2)S(=O)(=O)c2c(C)noc2C)c1 nan
1000713 22469 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 5 0 3 4.4 Cc1ccc(S(=O)(=O)N(CC(=O)N2CCc3ccccc3C2)c2cccc(Cl)c2)cc1 nan
CHEMBL1325057 22469 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 5 0 3 4.4 Cc1ccc(S(=O)(=O)N(CC(=O)N2CCc3ccccc3C2)c2cccc(Cl)c2)cc1 nan
1051135 22471 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 6 0 6 4.1 CCS(=O)(=O)n1nc(-c2ccc(Cl)cc2)nc1SCc1ccccc1 nan
CHEMBL1325062 22471 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 6 0 6 4.1 CCS(=O)(=O)n1nc(-c2ccc(Cl)cc2)nc1SCc1ccccc1 nan
3241194 22483 None 6 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 3 4.0 Cc1c(C(=O)OC2CCCCC2)[nH]c2c1C(=O)CC(C)(C)C2 nan
CHEMBL1325194 22483 None 6 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 1 3 4.0 Cc1c(C(=O)OC2CCCCC2)[nH]c2c1C(=O)CC(C)(C)C2 nan
3213708 22485 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 8 1 8 3.8 COc1ccc(NC(=O)CSc2nnc(-c3ccoc3C)n2CC2CCCO2)cc1 nan
CHEMBL1325214 22485 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 8 1 8 3.8 COc1ccc(NC(=O)CSc2nnc(-c3ccoc3C)n2CC2CCCO2)cc1 nan
16189312 22492 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 9 1 6 3.9 O=C(CCCn1c(SCc2cccc(F)c2)nc2ccccc2c1=O)NCC1CCCO1 nan
CHEMBL1325278 22492 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 9 1 6 3.9 O=C(CCCn1c(SCc2cccc(F)c2)nc2ccccc2c1=O)NCC1CCCO1 nan
5147088 22509 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 9 0 4 5.2 CCC(=O)N(CCC1(c2ccccc2OC)CCOC(C(C)C)C1)Cc1ccco1 nan
CHEMBL1325461 22509 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 9 0 4 5.2 CCC(=O)N(CCC1(c2ccccc2OC)CCOC(C(C)C)C1)Cc1ccco1 nan
4971 22520 None 43 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 562 8 4 4 7.5 C=CC1=C(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)C(CCC(=O)O)=C4C)c(C)c3C=C nan
CHEMBL1325592 22520 None 43 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 562 8 4 4 7.5 C=CC1=C(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)C(CCC(=O)O)=C4C)c(C)c3C=C nan
663657 22542 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 5 1 6 3.3 COc1cc(OC)cc(C(=O)OCc2cc3ccccc3nc2O)c1 nan
CHEMBL1325825 22542 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 5 1 6 3.3 COc1cc(OC)cc(C(=O)OCc2cc3ccccc3nc2O)c1 nan
1294862 22549 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 1 2 6 3.9 O=C1CCCC2=C1C1(CCCCC1)NC(Nc1nc3ccccc3o1)=N2 nan
CHEMBL1325876 22549 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 1 2 6 3.9 O=C1CCCC2=C1C1(CCCCC1)NC(Nc1nc3ccccc3o1)=N2 nan
794181 22579 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 344 4 4 6 4.5 Oc1ccc(Nc2nc3ccccc3nc2Nc2ccc(O)cc2)cc1 nan
CHEMBL1326180 22579 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 344 4 4 6 4.5 Oc1ccc(Nc2nc3ccccc3nc2Nc2ccc(O)cc2)cc1 nan
15945382 22598 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 8 2 6 4.4 COc1cc(/C=C/C(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc(OC)c1O nan
CHEMBL1326403 22598 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 8 2 6 4.4 COc1cc(/C=C/C(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc(OC)c1O nan
16193460 22600 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 511 11 2 9 3.6 Cc1cc(NC(=O)CSc2nc3ccsc3c(=O)n2CCCC(=O)NCCc2ccccc2)no1 nan
CHEMBL1326413 22600 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 511 11 2 9 3.6 Cc1cc(NC(=O)CSc2nc3ccsc3c(=O)n2CCCC(=O)NCCc2ccccc2)no1 nan
3710189 22602 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 0 5 4.1 COc1ccc(C2=NN3C(C2)c2ccccc2OC32C(=O)N(C)c3ccccc32)cc1 nan
CHEMBL1326444 22602 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 0 5 4.1 COc1ccc(C2=NN3C(C2)c2ccccc2OC32C(=O)N(C)c3ccccc32)cc1 nan
3236242 22604 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 5 0 5 4.2 COc1ccc(OC)c(C2SCCN2S(=O)(=O)c2cccc(C(F)(F)F)c2)c1 nan
CHEMBL1326451 22604 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 5 0 5 4.2 COc1ccc(OC)c(C2SCCN2S(=O)(=O)c2cccc(C(F)(F)F)c2)c1 nan
661919 22607 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 1 0 4 4.3 CN1c2ccccc2-c2nc3ccccc3n2C1c1ccco1 nan
CHEMBL1326489 22607 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 1 0 4 4.3 CN1c2ccccc2-c2nc3ccccc3n2C1c1ccco1 nan
16190905 22612 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 7 0 5 4.4 CCOC(=O)C1(CCc2ccccc2)CCN(Cc2cccc3nccnc23)CC1 nan
CHEMBL1326532 22612 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 7 0 5 4.4 CCOC(=O)C1(CCc2ccccc2)CCN(Cc2cccc3nccnc23)CC1 nan
647234 22616 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 258 1 0 3 3.0 Cc1cc(C)n(-c2cccc(Cl)c2)c(=O)c1C#N nan
CHEMBL1326573 22616 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 258 1 0 3 3.0 Cc1cc(C)n(-c2cccc(Cl)c2)c(=O)c1C#N nan
659200 22634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 2 9 1.7 OCCN(CCO)c1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3 nan
CHEMBL1326723 22634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 2 9 1.7 OCCN(CCO)c1ncnc2c1sc1nc(N3CCOCC3)c3c(c12)CCCC3 nan
3529029 22635 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 6 1 5 4.9 O=C(CSc1cn(Cc2ccccc2)c2ccccc12)Nc1nccs1 nan
CHEMBL1326724 22635 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 6 1 5 4.9 O=C(CSc1cn(Cc2ccccc2)c2ccccc12)Nc1nccs1 nan
794333 22636 None 41 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 0 2 3.7 COc1ccc(C(=O)c2ccc(Br)cc2)cc1 nan
CHEMBL1326786 22636 None 41 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 0 2 3.7 COc1ccc(C(=O)c2ccc(Br)cc2)cc1 nan
2290906 22640 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 9 1 4 2.5 COCCCNC(=O)CN(C1CCCCC1)S(=O)(=O)c1ccc(C)cc1 nan
CHEMBL1326808 22640 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 9 1 4 2.5 COCCCNC(=O)CN(C1CCCCC1)S(=O)(=O)c1ccc(C)cc1 nan
2732574 22643 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 5 1 8 0.1 COc1ccccc1C(C[N+](=O)[O-])c1c(N)n(C)c(=O)n(C)c1=O nan
CHEMBL1326817 22643 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 5 1 8 0.1 COc1ccccc1C(C[N+](=O)[O-])c1c(N)n(C)c(=O)n(C)c1=O nan
3953791 22644 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 4 2 3 4.8 O=C(Nc1cccc(Cl)c1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl nan
CHEMBL1326819 22644 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 4 2 3 4.8 O=C(Nc1cccc(Cl)c1)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl nan
647595 22645 None 1 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 7 2 8 3.8 CC(C)c1ccc(Nc2nc(NCc3ccco3)nc(N3CCOCC3)n2)cc1 nan
CHEMBL1326826 22645 None 1 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 7 2 8 3.8 CC(C)c1ccc(Nc2nc(NCc3ccco3)nc(N3CCOCC3)n2)cc1 nan
4831254 22648 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 512 5 2 5 6.4 CC1=C(C(=O)Nc2ccc([N+](=O)[O-])cc2)C(c2cccc(C(F)(F)F)c2)N=C(S)N1c1ccccc1 nan
CHEMBL1326851 22648 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 512 5 2 5 6.4 CC1=C(C(=O)Nc2ccc([N+](=O)[O-])cc2)C(c2cccc(C(F)(F)F)c2)N=C(S)N1c1ccccc1 nan
6407386 22650 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 6 0 6 4.3 COc1ccc(OCC(=O)N2CCN(c3nnc(-c4ccc(C)cc4)c4ccccc34)CC2)cc1 nan
CHEMBL1326873 22650 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 6 0 6 4.3 COc1ccc(OCC(=O)N2CCN(c3nnc(-c4ccc(C)cc4)c4ccccc34)CC2)cc1 nan
3242141 22664 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 4.1 O=C(c1noc2c1CCCC2)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL1327006 22664 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 4.1 O=C(c1noc2c1CCCC2)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
3241953 22677 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 276 5 1 4 2.1 CCC(C)NC(=O)C1CC(c2cccc(OC)c2)=NO1 nan
CHEMBL1327092 22677 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 276 5 1 4 2.1 CCC(C)NC(=O)C1CC(c2cccc(OC)c2)=NO1 nan
2487681 22698 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 7 2 7 3.1 C=CCn1c(SCC(=O)Nc2sccc2C(N)=O)nc2ccc(Cl)cc2c1=O nan
CHEMBL1327237 22698 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 7 2 7 3.1 C=CCn1c(SCC(=O)Nc2sccc2C(N)=O)nc2ccc(Cl)cc2c1=O nan
4253856 22722 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 356 6 1 3 5.1 Cc1ccc(SC(CC(=O)c2ccc(C(C)(C)C)cc2)C(=O)O)cc1 nan
CHEMBL1327531 22722 None 21 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 356 6 1 3 5.1 Cc1ccc(SC(CC(=O)c2ccc(C(C)(C)C)cc2)C(=O)O)cc1 nan
16746595 22733 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 9 4 7 4.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)OC(C)(C)C nan
CHEMBL1327593 22733 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 9 4 7 4.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)Nc1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)OC(C)(C)C nan
2841620 22737 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 4 3.5 CCOC(=O)C1=C(Cc2ccc(C)cc2)C(=O)c2ccccc2C1=O nan
CHEMBL1327627 22737 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 4 3.5 CCOC(=O)C1=C(Cc2ccc(C)cc2)C(=O)c2ccccc2C1=O nan
1023409 22745 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 3 1 4 5.2 Cc1ccc2c(N)c(C(=O)N(c3ccccc3)c3ccccc3)sc2n1 nan
CHEMBL1327683 22745 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 3 1 4 5.2 Cc1ccc2c(N)c(C(=O)N(c3ccccc3)c3ccccc3)sc2n1 nan
714054 22747 None 6 Human Functional pPotency = 5 5.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 4 0 5 4.2 N#Cc1nc(COc2ccc(Cl)cc2)oc1N1CCCCCC1 nan
CHEMBL1327690 22747 None 6 Human Functional pPotency = 5 5.0 -1 4
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 4 0 5 4.2 N#Cc1nc(COc2ccc(Cl)cc2)oc1N1CCCCCC1 nan
2645777 22770 None 10 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 300 1 1 3 4.4 N#Cc1c(S)nc(-c2ccccc2Cl)c2c1CCCC2 nan
CHEMBL1327817 22770 None 10 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 300 1 1 3 4.4 N#Cc1c(S)nc(-c2ccccc2Cl)c2c1CCCC2 nan
328144 22771 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 3 2 3 5.0 OC(c1cc(-c2ccc(C(F)(F)F)cc2)nc(C(F)(F)F)c1)C1CCCCN1 nan
CHEMBL1327821 22771 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 3 2 3 5.0 OC(c1cc(-c2ccc(C(F)(F)F)cc2)nc(C(F)(F)F)c1)C1CCCCN1 nan
2727056 22786 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 3 5.9 CCN(C(=O)c1cnc(NC(C)C)cc1C(F)(F)F)c1ccc(Cl)cc1Cl nan
CHEMBL1327905 22786 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 3 5.9 CCN(C(=O)c1cnc(NC(C)C)cc1C(F)(F)F)c1ccc(Cl)cc1Cl nan
647945 22802 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 6 1 9 2.2 CCn1c(SCC(=O)Nc2ccccc2N2CCCCC2)nc2c1c(=O)n(C)c(=O)n2C nan
CHEMBL1328045 22802 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 6 1 9 2.2 CCn1c(SCC(=O)Nc2ccccc2N2CCCCC2)nc2c1c(=O)n(C)c(=O)n2C nan
4195878 22815 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 3 1 6 3.7 CC1CCCN(C(=O)c2ccc3c(=O)n(Cc4ccc5c(c4)OCO5)c(=S)[nH]c3c2)C1 nan
CHEMBL1328117 22815 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 3 1 6 3.7 CC1CCCN(C(=O)c2ccc3c(=O)n(Cc4ccc5c(c4)OCO5)c(=S)[nH]c3c2)C1 nan
3238142 22828 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 1 6 7.2 CC(C)(C)c1ccc(C(=O)CCCSC2=C(C#N)C(c3ccco3)C3=C(O)CCCC3=N2)cc1 nan
CHEMBL1328202 22828 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 1 6 7.2 CC(C)(C)c1ccc(C(=O)CCCSC2=C(C#N)C(c3ccco3)C3=C(O)CCCC3=N2)cc1 nan
2830804 22831 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 3 2 6 5.4 O=c1c(C(c2ccccc2)c2c(O)sc3ccccc3c2=O)c(O)sc2ccccc12 nan
CHEMBL1328224 22831 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 3 2 6 5.4 O=c1c(C(c2ccccc2)c2c(O)sc3ccccc3c2=O)c(O)sc2ccccc12 nan
2955678 22857 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 1 4 3.7 CC(C)Oc1ccccc1C1CC(=O)Nc2cc3c(cc21)OCCO3 nan
CHEMBL1328466 22857 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 1 4 3.7 CC(C)Oc1ccccc1C1CC(=O)Nc2cc3c(cc21)OCCO3 nan
102121086 22862 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 288 4 2 5 2.6 COc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2O)cc1 nan
487737 22862 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 288 4 2 5 2.6 COc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2O)cc1 nan
CHEMBL1328504 22862 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 288 4 2 5 2.6 COc1ccc(NC(=O)c2cc([N+](=O)[O-])ccc2O)cc1 nan
5048043 22876 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 4 0 4 5.0 Cc1nn(C)cc1CN(C)C(=O)c1cc(-c2ccccc2)nc2ccc(Br)cc12 nan
CHEMBL1328648 22876 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 4 0 4 5.0 Cc1nn(C)cc1CN(C)C(=O)c1cc(-c2ccccc2)nc2ccc(Br)cc12 nan
654377 22898 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 10 1 9 5.0 CCC(c1nnnn1Cc1ccco1)N(Cc1ccccc1OC)Cc1cc2cc(C)ccc2nc1O nan
CHEMBL1328884 22898 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 10 1 9 5.0 CCC(c1nnnn1Cc1ccco1)N(Cc1ccccc1OC)Cc1cc2cc(C)ccc2nc1O nan
1348714 22942 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 6 0 3 4.4 COc1ccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(C)cc2)cc1 nan
CHEMBL1329253 22942 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 6 0 3 4.4 COc1ccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(C)cc2)cc1 nan
2241247 22943 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 525 6 1 8 6.0 CC1(C)CC(=O)c2c(nc(SCC(=O)Nc3nsc(-c4ccccc4)n3)c(C#N)c2-c2ccccc2)C1 nan
CHEMBL1329255 22943 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 525 6 1 8 6.0 CC1(C)CC(=O)c2c(nc(SCC(=O)Nc3nsc(-c4ccccc4)n3)c(C#N)c2-c2ccccc2)C1 nan
769170 22950 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 4 1 4 3.3 CCC(=O)c1cc2c(cc1NC(=O)c1ccccc1)OCCO2 nan
CHEMBL1329328 22950 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 4 1 4 3.3 CCC(=O)c1cc2c(cc1NC(=O)c1ccccc1)OCCO2 nan
660767 22955 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 6 0 8 4.5 C=CCSc1nnc2n(CCc3ccccc3)c(=O)c3c4c(sc3n12)COC(C)(C)C4 nan
CHEMBL1329371 22955 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 452 6 0 8 4.5 C=CCSc1nnc2n(CCc3ccccc3)c(=O)c3c4c(sc3n12)COC(C)(C)C4 nan
651367 22975 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 3 1 6 4.7 Cc1cccc(N2CCN(C(=O)c3cc4n(n3)C(C(F)(F)F)CC(c3ccco3)N4)CC2)c1C nan
CHEMBL1329561 22975 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 3 1 6 4.7 Cc1cccc(N2CCN(C(=O)c3cc4n(n3)C(C(F)(F)F)CC(c3ccco3)N4)CC2)c1C nan
328773 22978 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 5 1 4 2.4 CCN(CC)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O nan
CHEMBL1329597 22978 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 5 1 4 2.4 CCN(CC)CCN1C(=O)c2cccc3cc(N)cc(c23)C1=O nan
649196 22982 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 4 0 6 3.5 Cc1ccc(Cl)cc1N1CCN(Cc2nnnn2C2CCCCC2)CC1 nan
CHEMBL1329612 22982 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 4 0 6 3.5 Cc1ccc(Cl)cc1N1CCN(Cc2nnnn2C2CCCCC2)CC1 nan
1889301 22983 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 5 1 4 4.2 Cc1ccc(-c2nn(C)c(=O)c3ccccc23)cc1CNC(=O)/C=C/c1ccccc1 nan
CHEMBL1329615 22983 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 5 1 4 4.2 Cc1ccc(-c2nn(C)c(=O)c3ccccc23)cc1CNC(=O)/C=C/c1ccccc1 nan
665435 22988 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 6 4.6 COc1ccc2nc3c(cc2c1)c(NC(=O)c1cccs1)nn3CC(C)C nan
CHEMBL1329661 22988 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 6 4.6 COc1ccc2nc3c(cc2c1)c(NC(=O)c1cccs1)nn3CC(C)C nan
2956016 22993 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 3 0 3 5.9 CCCN1C2=C(C(=O)CC(C)(C)C2)C(c2ccc(F)cc2)C2=C1c1ccccc1C2=O nan
CHEMBL1329706 22993 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 3 0 3 5.9 CCCN1C2=C(C(=O)CC(C)(C)C2)C(c2ccc(F)cc2)C2=C1c1ccccc1C2=O nan
11841561 23016 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 477 4 2 6 6.0 COc1ccc(C2NC(=O)c3sc4nc(C)c(C(C)=O)c(-c5ccc(Cl)cc5)c4c3N2)cc1 nan
CHEMBL1329895 23016 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 477 4 2 6 6.0 COc1ccc(C2NC(=O)c3sc4nc(C)c(C(C)=O)c(-c5ccc(Cl)cc5)c4c3N2)cc1 nan
656260 23032 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 0 4 4.0 O=C(C1CCCN(S(=O)(=O)c2ccc(Cl)cc2)C1)N(Cc1cccs1)C1CC1 nan
CHEMBL1330034 23032 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 0 4 4.0 O=C(C1CCCN(S(=O)(=O)c2ccc(Cl)cc2)C1)N(Cc1cccs1)C1CC1 nan
2058723 23037 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 279 8 1 3 4.0 CCCCCCC(=O)c1c(C)[nH]c(C(=O)OCC)c1C nan
CHEMBL1330065 23037 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 279 8 1 3 4.0 CCCCCCC(=O)c1c(C)[nH]c(C(=O)OCC)c1C nan
3235586 23042 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 8 1 4 4.3 CCCCCn1c(CCNC(=O)c2cccs2)nc2ccccc21 nan
CHEMBL1330105 23042 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 8 1 4 4.3 CCCCCn1c(CCNC(=O)c2cccs2)nc2ccccc21 nan
1337443 23066 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 7 1 5 3.9 Cc1ccc(S(=O)(=O)N(CC(=O)Nc2cccc([N+](=O)[O-])c2)C2CCCCC2)cc1 nan
CHEMBL1330339 23066 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 7 1 5 3.9 Cc1ccc(S(=O)(=O)N(CC(=O)Nc2cccc([N+](=O)[O-])c2)C2CCCCC2)cc1 nan
2281759 23075 None 5 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 3 1 4 4.1 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
CHEMBL1330390 23075 None 5 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 3 1 4 4.1 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
16187776 23083 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 3 2 3 4.7 O=C(c1cc(-c2ccccc2)[nH]n1)N1CCc2c([nH]c3ccccc23)C1c1ccccn1 nan
CHEMBL1330453 23083 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 3 2 3 4.7 O=C(c1cc(-c2ccccc2)[nH]n1)N1CCc2c([nH]c3ccccc23)C1c1ccccn1 nan
1070537 23089 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 6 0 3 4.6 CCOc1ccccc1C(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL1330503 23089 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 6 0 3 4.6 CCOc1ccccc1C(=O)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
3724486 23100 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 10 1 4 4.9 CC(C)CCN(CCC(C)C)CC(O)Cn1c2ccccc2c(=O)c2ccccc21 nan
CHEMBL1330625 23100 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 10 1 4 4.9 CC(C)CCN(CCC(C)C)CC(O)Cn1c2ccccc2c(=O)c2ccccc21 nan
9550907 23107 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 6 0 5 3.9 Cc1nn(C)c(C)c1S(=O)(=O)N(CC(=O)N1CCc2ccccc2C1)c1ccc(C(C)C)cc1 nan
CHEMBL1330668 23107 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 6 0 5 3.9 Cc1nn(C)c(C)c1S(=O)(=O)N(CC(=O)N1CCc2ccccc2C1)c1ccc(C(C)C)cc1 nan
935329 23117 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 3 4.5 O=C(NCc1cccnc1)c1sc2cc(Cl)ccc2c1Cl nan
CHEMBL1330751 23117 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 3 4.5 O=C(NCc1cccnc1)c1sc2cc(Cl)ccc2c1Cl nan
1739929 23126 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 0 2 4.8 Cc1cc(Cl)ccc1OCCCC(=O)N1CCCc2ccccc21 nan
CHEMBL1330835 23126 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 5 0 2 4.8 Cc1cc(Cl)ccc1OCCCC(=O)N1CCCc2ccccc21 nan
645974 23157 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 492 8 1 10 4.1 COc1ccc2nc(O)c(C(c3nnnn3C(C)(C)C)N(Cc3ccco3)CC3CCCO3)cc2c1 nan
CHEMBL1330994 23157 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 492 8 1 10 4.1 COc1ccc2nc(O)c(C(c3nnnn3C(C)(C)C)N(Cc3ccco3)CC3CCCO3)cc2c1 nan
2105272 23192 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 4 0 7 5.1 Cc1noc(C)c1CSc1nc2sc(C)c(C)c2c(=O)n1C1CCCC1 nan
CHEMBL1331239 23192 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 4 0 7 5.1 Cc1noc(C)c1CSc1nc2sc(C)c(C)c2c(=O)n1C1CCCC1 nan
879111 23220 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 3 0 4 4.1 Fc1ccc(-c2cc(-c3ccccc3)nc(-n3cccn3)n2)cc1 nan
CHEMBL1331439 23220 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 3 0 4 4.1 Fc1ccc(-c2cc(-c3ccccc3)nc(-n3cccn3)n2)cc1 nan
3244198 23221 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 5 0 7 3.8 Cc1ccnc(N2CCN(C(=O)CSc3nc4ccccc4nc3N3CCCCC3)CC2)c1 nan
CHEMBL1331442 23221 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 5 0 7 3.8 Cc1ccnc(N2CCN(C(=O)CSc3nc4ccccc4nc3N3CCCCC3)CC2)c1 nan
2607886 23227 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 0 6 5.1 COc1ccc(N2C(=O)/C(=C\c3ccco3)N=C2SCC(=O)N(C(C)C)C(C)C)cc1Cl nan
CHEMBL1331498 23227 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 0 6 5.1 COc1ccc(N2C(=O)/C(=C\c3ccco3)N=C2SCC(=O)N(C(C)C)C(C)C)cc1Cl nan
2820176 23236 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 3 0 5 4.2 CSc1sc(C(=O)OC(C)C)c2c1C(=O)CC(C)(C)C2 nan
CHEMBL1331599 23236 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 3 0 5 4.2 CSc1sc(C(=O)OC(C)C)c2c1C(=O)CC(C)(C)C2 nan
3711253 23250 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 3 1 6 1.9 Cc1ccc(C(=O)Nc2nc(=O)n(C(=O)C3CC3)s2)cc1 nan
CHEMBL1331665 23250 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 3 1 6 1.9 Cc1ccc(C(=O)Nc2nc(=O)n(C(=O)C3CC3)s2)cc1 nan
663373 23261 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 6 2 7 4.4 CCOC(=O)C(C(C)=O)c1c(Br)c(O)c(O)c2c(C(=O)c3ccc(C)cc3)coc12 nan
CHEMBL1331809 23261 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 6 2 7 4.4 CCOC(=O)C(C(C)=O)c1c(Br)c(O)c(O)c2c(C(=O)c3ccc(C)cc3)coc12 nan
1090853 23293 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 3.9 O=C(NCc1ccc2c(c1)OCO2)c1ccc(CN2CCc3ccccc3C2)cc1 nan
CHEMBL1332038 23293 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 3.9 O=C(NCc1ccc2c(c1)OCO2)c1ccc(CN2CCc3ccccc3C2)cc1 nan
2834912 23298 None 23 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 3 5.3 Clc1ccc(C2=NN(c3ccccc3)C(c3ccco3)C2)cc1 nan
CHEMBL1332070 23298 None 23 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 3 5.3 Clc1ccc(C2=NN(c3ccccc3)C(c3ccco3)C2)cc1 nan
2553545 23300 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 472 7 0 6 3.6 Cc1cc(C(=O)CN(Cc2ccc(F)cc2)S(=O)(=O)c2ccc3c(c2)OCCO3)c(C)n1C nan
CHEMBL1332076 23300 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 472 7 0 6 3.6 Cc1cc(C(=O)CN(Cc2ccc(F)cc2)S(=O)(=O)c2ccc3c(c2)OCCO3)c(C)n1C nan
751394 23309 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 3 1 4 4.8 Cc1cccc(C)c1Nc1c(-c2ccccn2)nc2ccccn12 nan
CHEMBL1332165 23309 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 3 1 4 4.8 Cc1cccc(C)c1Nc1c(-c2ccccn2)nc2ccccn12 nan
7341556 23315 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 2 1 4 2.9 CN1C(=O)/C(=C/c2cccn2-c2ccc3ccccc3c2)C(=O)NC1=S nan
CHEMBL1332241 23315 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 2 1 4 2.9 CN1C(=O)/C(=C/c2cccn2-c2ccc3ccccc3c2)C(=O)NC1=S nan
658809 23330 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 466 8 1 7 4.4 c1ccc(Cn2c(CNc3nc4ccccc4n3CCN3CCOCC3)nc3ccccc32)cc1 nan
CHEMBL1332318 23330 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 466 8 1 7 4.4 c1ccc(Cn2c(CNc3nc4ccccc4n3CCN3CCOCC3)nc3ccccc32)cc1 nan
3189892 23333 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 8 0 5 4.2 CC1CCCCN1S(=O)(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)Cc2ccco2)cc1 nan
CHEMBL1332334 23333 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 8 0 5 4.2 CC1CCCCN1S(=O)(=O)c1ccc(S(=O)(=O)N(Cc2ccccc2)Cc2ccco2)cc1 nan
4569071 23351 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 6 1 5 3.8 O=C1/C(=C/Nc2cccnc2Cl)C(=O)N(C2CCCCC2)C(=O)N1CCCCl nan
CHEMBL1332467 23351 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 6 1 5 3.8 O=C1/C(=C/Nc2cccnc2Cl)C(=O)N(C2CCCCC2)C(=O)N1CCCCl nan
11949176 23376 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 477 5 0 3 6.8 Clc1ccc(C2[C@H]3CN(Cc4cccnc4)[C@H](c4ccccc4)C34CC2(c2ccccc2)C4)cn1 nan
CHEMBL1332667 23376 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 477 5 0 3 6.8 Clc1ccc(C2[C@H]3CN(Cc4cccnc4)[C@H](c4ccccc4)C34CC2(c2ccccc2)C4)cn1 nan
1861856 23383 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 4 2 6 2.5 COc1cc2[nH]c(=S)n(NC(=O)c3ccccc3)c(=O)c2cc1OC nan
CHEMBL1332727 23383 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 4 2 6 2.5 COc1cc2[nH]c(=S)n(NC(=O)c3ccccc3)c(=O)c2cc1OC nan
1542038 23387 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 8 2 8 5.0 CCOC(=O)c1ccc(NC(=O)CSc2nc(NC(=O)c3ccccc3)c3c(C)c(C)oc3n2)cc1 nan
CHEMBL1332734 23387 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 8 2 8 5.0 CCOC(=O)c1ccc(NC(=O)CSc2nc(NC(=O)c3ccccc3)c3c(C)c(C)oc3n2)cc1 nan
875306 23400 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 269 5 1 3 3.2 CCN(CC)c1ccc(NC(=O)c2cccnc2)cc1 nan
CHEMBL1332872 23400 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 269 5 1 3 3.2 CCN(CC)c1ccc(NC(=O)c2cccnc2)cc1 nan
2766071 23412 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 5 1 5 4.4 Cc1cc(C(=O)C(=O)Nc2ccccc2)c(C)n1-c1ccc(N2CCOCC2)c(Cl)c1 nan
CHEMBL1332925 23412 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 5 1 5 4.4 Cc1cc(C(=O)C(=O)Nc2ccccc2)c(C)n1-c1ccc(N2CCOCC2)c(Cl)c1 nan
1897510 23418 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 8 1 4 4.9 CCCCCc1nc(N)c(C#N)c(-c2ccco2)c1CCCC nan
CHEMBL1332963 23418 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 311 8 1 4 4.9 CCCCCc1nc(N)c(C#N)c(-c2ccco2)c1CCCC nan
2265768 23433 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 3 0 5 3.4 COC(=O)C1=C(C)N(C)C(C)=C(C(=O)OC)C1c1cccc(Br)c1 nan
CHEMBL1333102 23433 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 393 3 0 5 3.4 COC(=O)C1=C(C)N(C)C(C)=C(C(=O)OC)C1c1cccc(Br)c1 nan
2157931 23436 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 6 2 2 5.8 Cc1[nH]c2ccc(F)cc2c1CCN(Cc1cccnc1)C(S)=Nc1cccc(F)c1 nan
CHEMBL1333119 23436 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 6 2 2 5.8 Cc1[nH]c2ccc(F)cc2c1CCN(Cc1cccnc1)C(S)=Nc1cccc(F)c1 nan
1872862 23438 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 5 1 4 4.4 CCCCNc1c2c(nc3c(-c4ccccc4)c(C)nn13)CCC2 nan
CHEMBL1333126 23438 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 5 1 4 4.4 CCCCNc1c2c(nc3c(-c4ccccc4)c(C)nn13)CCC2 nan
1190210 23440 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 7 1 9 2.1 CCOC(=O)c1cc(C(=O)OCC)cc(-n2cc(O)c(C(=O)OCC)n2)c1 nan
CHEMBL1333144 23440 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 7 1 9 2.1 CCOC(=O)c1cc(C(=O)OCC)cc(-n2cc(O)c(C(=O)OCC)n2)c1 nan
2791433 23454 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 5 0 5 3.1 COc1ccc(N2C(=O)C(Cl)=C(Oc3cccc(OC)c3)C2=O)cc1 nan
CHEMBL1333268 23454 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 5 0 5 3.1 COc1ccc(N2C(=O)C(Cl)=C(Oc3cccc(OC)c3)C2=O)cc1 nan
16060556 23487 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 503 6 0 3 7.6 COc1ccc(-c2c([C@H]3[C@@H]4C=CCC[C@@]4(C)C(=O)N3Cc3ccccc3)ccc3ccccc23)cc1OC nan
CHEMBL1333523 23487 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 503 6 0 3 7.6 COc1ccc(-c2c([C@H]3[C@@H]4C=CCC[C@@]4(C)C(=O)N3Cc3ccccc3)ccc3ccccc23)cc1OC nan
3229211 23488 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 6 0 7 4.1 CCC(C)(C)n1nnnc1C(c1cccnc1)N1CCN(c2cccc(C(F)(F)F)c2)CC1 nan
CHEMBL1333527 23488 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 6 0 7 4.1 CCC(C)(C)n1nnnc1C(c1cccnc1)N1CCN(c2cccc(C(F)(F)F)c2)CC1 nan
1264499 23496 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 7 0 6 5.0 N#Cc1ccc(CSc2nnc(COc3ccccc3)n2-c2ccccc2)cc1 nan
CHEMBL1333585 23496 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 7 0 6 5.0 N#Cc1ccc(CSc2nnc(COc3ccccc3)n2-c2ccccc2)cc1 nan
711826 23506 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 294 5 0 4 3.7 CCCn1c(C(=O)c2ccccc2OC)nc2ccccc21 nan
CHEMBL1333680 23506 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 294 5 0 4 3.7 CCCn1c(C(=O)c2ccccc2OC)nc2ccccc21 nan
1298840 23508 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 6 1 7 5.1 CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1-c1ccc(Br)cc1 nan
CHEMBL1333690 23508 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 6 1 7 5.1 CCn1c(SCC(=O)Nc2nc3ccccc3s2)nnc1-c1ccc(Br)cc1 nan
1067709 23509 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 6 2 5 5.1 CC(C)c1ccc(NC(=O)c2cnn(-c3ccccc3)c2NC(=O)c2ccco2)cc1 nan
CHEMBL1333698 23509 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 6 2 5 5.1 CC(C)c1ccc(NC(=O)c2cnn(-c3ccccc3)c2NC(=O)c2ccco2)cc1 nan
1540788 23528 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 5 1 7 2.6 COc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)Nc1nc2ccccc2s1 nan
CHEMBL1333836 23528 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 5 1 7 2.6 COc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)Nc1nc2ccccc2s1 nan
2814378 23539 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 8 1 7 3.3 CCOC(=O)N1CCN(CC(=O)Nc2sc(CC)cc2C(=O)c2ccc(OC)cc2)CC1 nan
CHEMBL1333935 23539 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 8 1 7 3.3 CCOC(=O)N1CCN(CC(=O)Nc2sc(CC)cc2C(=O)c2ccc(OC)cc2)CC1 nan
1250940 23545 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 10 0 9 5.4 COc1ccc(-c2noc(CSc3nnc(CCc4ccccc4)n3-c3ccccc3)n2)cc1OC nan
CHEMBL1333962 23545 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 10 0 9 5.4 COc1ccc(-c2noc(CSc3nnc(CCc4ccccc4)n3-c3ccccc3)n2)cc1OC nan
4561725 23555 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 3 0 6 3.2 O=C1C(Cl)=C(N2CCN(c3ccccc3[N+](=O)[O-])CC2)C(=O)c2ccccc21 nan
CHEMBL1334040 23555 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 3 0 6 3.2 O=C1C(Cl)=C(N2CCN(c3ccccc3[N+](=O)[O-])CC2)C(=O)c2ccccc21 nan
2744108 23569 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 1 5 5.1 Cc1noc(-c2ccc(Cl)cc2)c1C(=O)ON=C(N)c1ccc(C(C)(C)C)cc1 nan
5703962 23569 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 1 5 5.1 Cc1noc(-c2ccc(Cl)cc2)c1C(=O)ON=C(N)c1ccc(C(C)(C)C)cc1 nan
9580868 23569 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 1 5 5.1 Cc1noc(-c2ccc(Cl)cc2)c1C(=O)ON=C(N)c1ccc(C(C)(C)C)cc1 nan
CHEMBL1334130 23569 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 1 5 5.1 Cc1noc(-c2ccc(Cl)cc2)c1C(=O)ON=C(N)c1ccc(C(C)(C)C)cc1 nan
4780744 23574 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 4 1 4 1.8 O=C(CN1CCN(c2ccccn2)CC1)Nc1ccccc1 nan
CHEMBL1334181 23574 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 4 1 4 1.8 O=C(CN1CCN(c2ccccn2)CC1)Nc1ccccc1 nan
2876957 23588 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 302 5 1 4 3.4 Cc1cc2ncn(CC(O)COC3CCCCC3)c2cc1C nan
CHEMBL1334287 23588 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 302 5 1 4 3.4 Cc1cc2ncn(CC(O)COC3CCCCC3)c2cc1C nan
4191109 23594 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 2 2 4 4.1 CC(C)C1C(C#N)=C(N)Oc2[nH]nc(-c3ccc4ccccc4c3)c21 nan
CHEMBL1334315 23594 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 2 2 4 4.1 CC(C)C1C(C#N)=C(N)Oc2[nH]nc(-c3ccc4ccccc4c3)c21 nan
1006299 23606 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 2 6 5.8 COc1ccc(OC)c(NC(=O)c2sc3nc(Cc4ccccc4)cc(C(F)(F)F)c3c2N)c1 nan
CHEMBL1334389 23606 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 2 6 5.8 COc1ccc(OC)c(NC(=O)c2sc3nc(Cc4ccccc4)cc(C(F)(F)F)c3c2N)c1 nan
2944357 23614 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 1 4 3.1 CCC(=O)N1CCN(c2ccccc2NC(=O)COc2cccc(C)c2)CC1 nan
CHEMBL1334461 23614 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 1 4 3.1 CCC(=O)N1CCN(c2ccccc2NC(=O)COc2cccc(C)c2)CC1 nan
655143 23626 None 0 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 4 3.8 Cc1cccc2cc(C#N)c(SCC(=O)N3CCC(C)CC3)nc12 nan
CHEMBL1334521 23626 None 0 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 4 3.8 Cc1cccc2cc(C#N)c(SCC(=O)N3CCC(C)CC3)nc12 nan
16197047 23628 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 2 6 4.2 CCO[C@@H]1OC(C(=O)Nc2ccccc2)=C[C@H](c2coc3ccccc3c2=O)[C@H]1CCCO nan
CHEMBL1334547 23628 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 2 6 4.2 CCO[C@@H]1OC(C(=O)Nc2ccccc2)=C[C@H](c2coc3ccccc3c2=O)[C@H]1CCCO nan
16189402 23656 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 534 9 1 3 6.9 FC(F)(F)c1cccc(NC(=S)N(CCCN2CCCC2)Cc2cccn2Cc2ccc(Cl)cc2)c1 nan
CHEMBL1334887 23656 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 534 9 1 3 6.9 FC(F)(F)c1cccc(NC(=S)N(CCCN2CCCC2)Cc2cccn2Cc2ccc(Cl)cc2)c1 nan
659003 23667 None 13 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 2 0 4 3.3 CCCN1C(=O)/C(=C2\SC(N3CCCCC3)=NC2=O)c2ccccc21 nan
CHEMBL1334962 23667 None 13 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 2 0 4 3.3 CCCN1C(=O)/C(=C2\SC(N3CCCCC3)=NC2=O)c2ccccc21 nan
1915472 23677 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 5 0 5 3.6 CCc1nc(OCC(=O)c2ccccc2)c(C#N)c2c1COC(C)(C)C2 nan
CHEMBL1335048 23677 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 5 0 5 3.6 CCc1nc(OCC(=O)c2ccccc2)c(C#N)c2c1COC(C)(C)C2 nan
11957303 23696 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 3 1 3 4.9 O=C1Nc2ccccc2/C1=C\c1cccn1-c1ccc(OC(F)(F)F)cc1 nan
CHEMBL1335149 23696 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 3 1 3 4.9 O=C1Nc2ccccc2/C1=C\c1cccn1-c1ccc(OC(F)(F)F)cc1 nan
9550765 23698 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 1 4 4.0 CCN(CC)S(=O)(=O)c1ccc2oc(C(=O)NCc3ccc(C)cc3)c(C)c2c1 nan
CHEMBL1335162 23698 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 1 4 4.0 CCN(CC)S(=O)(=O)c1ccc2oc(C(=O)NCc3ccc(C)cc3)c(C)c2c1 nan
1190011 23723 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 4 1 7 3.9 C=CCn1c(=O)c2c3c(sc2n2c(Nc4ccccc4)nnc12)CCCC3 nan
CHEMBL1335353 23723 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 4 1 7 3.9 C=CCn1c(=O)c2c3c(sc2n2c(Nc4ccccc4)nnc12)CCCC3 nan
940797 23728 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 282 3 1 6 0.6 Cc1nc(-c2ccccc2O)n(S(=O)(=O)N(C)C)n1 nan
CHEMBL1335380 23728 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 282 3 1 6 0.6 Cc1nc(-c2ccccc2O)n(S(=O)(=O)N(C)C)n1 nan
2963391 23731 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 CCS(=O)(=O)Nc1ccc(C2=NN(C(=O)c3ccco3)C(c3ccc(C)cc3)C2)cc1 nan
CHEMBL1335401 23731 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 6 1 5 4.3 CCS(=O)(=O)Nc1ccc(C2=NN(C(=O)c3ccco3)C(c3ccc(C)cc3)C2)cc1 nan
2267112 23772 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 4 3.1 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C\C=C\c3ccco3)C2=O)c1 nan
CHEMBL1335687 23772 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 4 3.1 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C\C=C\c3ccco3)C2=O)c1 nan
2841060 23780 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 4 0 3 4.2 COC(=O)C(C)N(C(=O)c1cccc(Cl)c1)c1c(C)cccc1C nan
CHEMBL1335743 23780 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 4 0 3 4.2 COC(=O)C(C)N(C(=O)c1cccc(Cl)c1)c1c(C)cccc1C nan
3241959 23781 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 7 0 5 2.8 CCCCn1c(N(CCOC(C)=O)C(C)=O)nc2ccccc21 nan
CHEMBL1335758 23781 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 7 0 5 2.8 CCCCn1c(N(CCOC(C)=O)C(C)=O)nc2ccccc21 nan
16193621 23785 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 5 1 5 3.3 CC1=CC2=NC(=O)/C(=C\c3cccn3CCOc3ccccc3C)C(=N)N2O1 nan
CHEMBL1335769 23785 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 5 1 5 3.3 CC1=CC2=NC(=O)/C(=C\c3cccn3CCOc3ccccc3C)C(=N)N2O1 nan
1489049 23788 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 4 1 5 4.8 Cc1cccc(Oc2sc(C(=O)c3ccccc3)c(N)c2C#N)c1C nan
CHEMBL1335775 23788 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 4 1 5 4.8 Cc1cccc(Oc2sc(C(=O)c3ccccc3)c(N)c2C#N)c1C nan
1367993 23793 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 4 4.9 Cc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ccccc2C(=O)NCc2ccco2)cc1 nan
CHEMBL1335865 23793 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 4 4.9 Cc1ccc(S(=O)(=O)N(Cc2ccccc2)c2ccccc2C(=O)NCc2ccco2)cc1 nan
3775134 23802 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 2 0 4 4.2 CC(C)(C)c1ccc(CN2N=Nc3ccccc3S2(=O)=O)cc1 nan
CHEMBL1335988 23802 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 2 0 4 4.2 CC(C)(C)c1ccc(CN2N=Nc3ccccc3S2(=O)=O)cc1 nan
2482266 23806 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 8 1 8 4.7 O=C(CSc1nnc(Cc2cccs2)n1-c1ccc(Cl)cc1)NCc1ccc2c(c1)OCO2 nan
CHEMBL1336026 23806 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 8 1 8 4.7 O=C(CSc1nnc(Cc2cccs2)n1-c1ccc(Cl)cc1)NCc1ccc2c(c1)OCO2 nan
5123661 23841 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 1 7 4.4 CCN(CC)CCn1c(SCC(=O)NCc2ccccc2)nc2c(sc3ccccc32)c1=O nan
CHEMBL1336292 23841 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 480 10 1 7 4.4 CCN(CC)CCn1c(SCC(=O)NCc2ccccc2)nc2c(sc3ccccc32)c1=O nan
955150 23845 None 6 Human Functional pPotency = 5 5.0 -1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 3 5.2 O=C(c1ccco1)c1cn(Cc2ccc(Cl)cc2)c2ccccc12 nan
CHEMBL1336318 23845 None 6 Human Functional pPotency = 5 5.0 -1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 335 4 0 3 5.2 O=C(c1ccco1)c1cn(Cc2ccc(Cl)cc2)c2ccccc12 nan
3193659 23851 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 3 0 5 4.6 CC(C)(C)n1nnnc1C(c1ccc(Cl)cc1)N1CCCc2ccccc21 nan
CHEMBL1336418 23851 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 3 0 5 4.6 CC(C)(C)n1nnnc1C(c1ccc(Cl)cc1)N1CCCc2ccccc21 nan
2763801 23853 None 24 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 285 3 0 3 4.4 Cn1c(Oc2ccc(Cl)cc2)c(C=O)c2ccccc21 nan
CHEMBL1336431 23853 None 24 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 285 3 0 3 4.4 Cn1c(Oc2ccc(Cl)cc2)c(C=O)c2ccccc21 nan
1405179 23868 None 4 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 5 1 4 4.5 Cc1cc(/C=C(\C#N)C(=O)NCc2cccs2)c(C)n1-c1ccccc1F nan
CHEMBL1336531 23868 None 4 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 5 1 4 4.5 Cc1cc(/C=C(\C#N)C(=O)NCc2cccs2)c(C)n1-c1ccccc1F nan
1811199 23872 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 4 4.1 Cc1cc(N2CCCC2=O)cc(C)c1S(=O)(=O)NCCOc1ccc(C(C)(C)C)cc1 nan
CHEMBL1336541 23872 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 4 4.1 Cc1cc(N2CCCC2=O)cc(C)c1S(=O)(=O)NCCOc1ccc(C(C)(C)C)cc1 nan
1258290 23883 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 1 6 4.4 Nc1cc(=O)nc(SCC(=O)N(C2CCCCC2)C2CCCCC2)n1-c1ccccc1 nan
CHEMBL1336622 23883 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 440 6 1 6 4.4 Nc1cc(=O)nc(SCC(=O)N(C2CCCCC2)C2CCCCC2)n1-c1ccccc1 nan
2809257 23907 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 3 2 3 5.2 O=C(Nc1ccc(-n2ccc(C(F)(F)F)n2)cc1)Nc1cccc(Cl)c1 nan
CHEMBL1336856 23907 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 3 2 3 5.2 O=C(Nc1ccc(-n2ccc(C(F)(F)F)n2)cc1)Nc1cccc(Cl)c1 nan
7120050 23911 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 1 1 4 3.9 O=c1c2oc3ccccc3c2[nH]c(=S)n1-c1ccc(F)cc1 nan
CHEMBL1336910 23911 None 8 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 1 1 4 3.9 O=c1c2oc3ccccc3c2[nH]c(=S)n1-c1ccc(F)cc1 nan
2382578 23915 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 7 2 6 4.5 CC(=O)Nc1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)CCN(Cc2ccccc2)C3)cc1 nan
CHEMBL1336931 23915 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 7 2 6 4.5 CC(=O)Nc1ccc(NC(=O)COC(=O)c2c3c(nc4ccccc24)CCN(Cc2ccccc2)C3)cc1 nan
6081455 23937 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 1 6 3.7 COc1cccc(/C=C2\SC(=S)N(C(C(=O)O)c3ccccc3)C2=O)c1OC nan
CHEMBL1337176 23937 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 1 6 3.7 COc1cccc(/C=C2\SC(=S)N(C(C(=O)O)c3ccccc3)C2=O)c1OC nan
3836619 23940 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 8 2 5 2.9 C=CCN1C(=O)NC(=O)/C(=C(/CC)Nc2ccc(N(CC)CC)cc2)C1=O nan
CHEMBL1337193 23940 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 8 2 5 2.9 C=CCN1C(=O)NC(=O)/C(=C(/CC)Nc2ccc(N(CC)CC)cc2)C1=O nan
3217760 23941 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 4 0 5 3.8 Cc1ccc(S(=O)(=O)n2c(CN3CCCC(C)C3)nc3ccccc32)cc1 nan
CHEMBL1337200 23941 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 4 0 5 3.8 Cc1ccc(S(=O)(=O)n2c(CN3CCCC(C)C3)nc3ccccc32)cc1 nan
5309622 23948 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 5 1 4 5.3 Cc1cc2c(cc(C(=O)N3CCC(C(=O)NC4CCCC4)CC3)n2Cc2c(F)cccc2Cl)o1 nan
CHEMBL1337266 23948 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 5 1 4 5.3 Cc1cc2c(cc(C(=O)N3CCC(C(=O)NC4CCCC4)CC3)n2Cc2c(F)cccc2Cl)o1 nan
3138569 23957 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 6 2 5 3.9 COc1ccc(OCC(=O)NNc2c3ccccc3nc3ccccc23)cc1 nan
CHEMBL1337347 23957 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 6 2 5 3.9 COc1ccc(OCC(=O)NNc2c3ccccc3nc3ccccc23)cc1 nan
1847235 23966 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 3 3 3 4.0 Cc1c(Cl)cccc1NC(=O)c1cc(-c2ccccc2O)[nH]n1 nan
CHEMBL1337423 23966 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 3 3 3 4.0 Cc1c(Cl)cccc1NC(=O)c1cc(-c2ccccc2O)[nH]n1 nan
1301366 23967 None 11 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 5 1 5 4.1 O=C(CCSc1nnc2ccc3ccccc3n12)Nc1ccc(F)cc1 nan
CHEMBL1337428 23967 None 11 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 5 1 5 4.1 O=C(CCSc1nnc2ccc3ccccc3n12)Nc1ccc(F)cc1 nan
1724248 23968 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 1 1 3 6.3 Cc1cc2c(cc1C)CSC(c1c(O)ccc3ccccc13)SC2 nan
CHEMBL1337445 23968 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 1 1 3 6.3 Cc1cc2c(cc1C)CSC(c1c(O)ccc3ccccc13)SC2 nan
1037259 23969 None 9 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 5 1 5 4.5 Cc1ccccc1NS(=O)(=O)c1cccc(-c2nnc(-c3ccccc3)o2)c1 nan
CHEMBL1337450 23969 None 9 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 5 1 5 4.5 Cc1ccccc1NS(=O)(=O)c1cccc(-c2nnc(-c3ccccc3)o2)c1 nan
2192108 23970 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 4 2 4 4.6 O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Br)cn1)c1ccco1 nan
CHEMBL1337451 23970 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 4 2 4 4.6 O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccc(Br)cn1)c1ccco1 nan
3136681 23971 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 1 3 3.9 Cc1cc(C)cc(NC(=O)C2CCCN2C(=O)Oc2ccccc2)c1 nan
CHEMBL1337468 23971 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 3 1 3 3.9 Cc1cc(C)cc(NC(=O)C2CCCN2C(=O)Oc2ccccc2)c1 nan
3238216 23992 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 10 1 7 2.7 CCOCCn1c(CN(Cc2ccccc2)Cc2ccccc2)nc2c1c(=O)[nH]c(=O)n2C nan
CHEMBL1337617 23992 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 10 1 7 2.7 CCOCCn1c(CN(Cc2ccccc2)Cc2ccccc2)nc2c1c(=O)[nH]c(=O)n2C nan
648113 24008 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 6 0 6 3.8 O=S(=O)(c1ccc(-c2nnc(SCc3ccccc3)o2)cc1)N1CCCC1 nan
CHEMBL1337785 24008 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 6 0 6 3.8 O=S(=O)(c1ccc(-c2nnc(SCc3ccccc3)o2)cc1)N1CCCC1 nan
3167769 24013 None 3 Human Functional pPotency = 5 5.0 -28 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 531 6 0 8 6.6 O=C(CSc1nnc(-c2ccncc2)n1Cc1ccco1)N1c2ccccc2Sc2ccc(Cl)cc21 nan
CHEMBL1337858 24013 None 3 Human Functional pPotency = 5 5.0 -28 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 531 6 0 8 6.6 O=C(CSc1nnc(-c2ccncc2)n1Cc1ccco1)N1c2ccccc2Sc2ccc(Cl)cc21 nan
3190948 24050 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 483 8 2 3 5.8 Cc1ccc(C(C(=O)NC2CCCCC2)N(Cc2ccccc2)C(=O)Cc2c[nH]c3ccccc23)o1 nan
CHEMBL1338171 24050 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 483 8 2 3 5.8 Cc1ccc(C(C(=O)NC2CCCCC2)N(Cc2ccccc2)C(=O)Cc2c[nH]c3ccccc23)o1 nan
11835476 24066 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 6 1 5 4.4 COCC(C)NC(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2cccs2)cc1 nan
CHEMBL1338284 24066 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 6 1 5 4.4 COCC(C)NC(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2cccs2)cc1 nan
6603892 24078 None 0 Human Functional pPotency = 5 5.0 -891 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 0 2 5.7 CCCn1c(C)c(C(=O)c2ccc3ccccc3c2)c2ccccc21 nan
CHEMBL1338358 24078 None 0 Human Functional pPotency = 5 5.0 -891 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 0 2 5.7 CCCn1c(C)c(C(=O)c2ccc3ccccc3c2)c2ccccc21 nan
652795 24090 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 5 0 8 3.6 Cc1ccc(Cn2nnnc2CN2CCC(n3nnc4cc(C(F)(F)F)ccc43)CC2)cc1 nan
CHEMBL1338416 24090 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 5 0 8 3.6 Cc1ccc(Cn2nnnc2CN2CCC(n3nnc4cc(C(F)(F)F)ccc43)CC2)cc1 nan
1265732 24092 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 5 1 4 5.4 O=C(Cn1c(S)nc(-c2ccccc2)c1-c1ccccc1)c1ccccc1 nan
CHEMBL1338427 24092 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 5 1 4 5.4 O=C(Cn1c(S)nc(-c2ccccc2)c1-c1ccccc1)c1ccccc1 nan
2498860 24108 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 5 1 4 6.5 Cc1cc(-c2csc(NC(=O)c3ccccc3C(F)(F)F)n2)c(C)n1Cc1ccccc1 nan
CHEMBL1338531 24108 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 5 1 4 6.5 Cc1cc(-c2csc(NC(=O)c3ccccc3C(F)(F)F)n2)c(C)n1Cc1ccccc1 nan
682310 24123 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 5 0 5 4.0 N#Cc1ccc(-c2cccnc2)nc1SCC(=O)c1ccccc1 nan
CHEMBL1338689 24123 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 5 0 5 4.0 N#Cc1ccc(-c2cccnc2)nc1SCC(=O)c1ccccc1 nan
2971368 24140 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 1 5 4.5 Cc1noc(C)c1C(=O)Nc1nc(C23CC4CC(CC(C4)C2)C3)cs1 nan
CHEMBL1338857 24140 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 1 5 4.5 Cc1noc(C)c1C(=O)Nc1nc(C23CC4CC(CC(C4)C2)C3)cs1 nan
664366 24146 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 7 1 7 4.3 CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cc(C)ccc2C)o1 nan
CHEMBL1338958 24146 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 7 1 7 4.3 CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cc(C)ccc2C)o1 nan
16060477 24150 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 5 0 2 6.6 COc1ccc(-c2ccc([C@H]3[C@@H]4C=CCC[C@@]4(C)C(=O)N3Cc3ccccc3)c(F)c2)cc1 nan
CHEMBL1339016 24150 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 5 0 2 6.6 COc1ccc(-c2ccc([C@H]3[C@@H]4C=CCC[C@@]4(C)C(=O)N3Cc3ccccc3)c(F)c2)cc1 nan
135419200 24171 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 2 8 3.5 CCOc1ccc(S(=O)(=O)NC(C)(C)C)cc1-c1nc(O)c2c(n1)c(C(C)(C)C)nn2C nan
CHEMBL1339229 24171 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 5 2 8 3.5 CCOc1ccc(S(=O)(=O)NC(C)(C)C)cc1-c1nc(O)c2c(n1)c(C(C)(C)C)nn2C nan
3242866 24177 None 2 Human Functional pPotency = 5 5.0 -25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 8 0 5 4.3 CCCN(CCC)C(=O)CSc1nc2ccccc2c(=O)n1C1CCCC1 nan
CHEMBL1339255 24177 None 2 Human Functional pPotency = 5 5.0 -25 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 8 0 5 4.3 CCCN(CCC)C(=O)CSc1nc2ccccc2c(=O)n1C1CCCC1 nan
4094710 24195 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 3 4.4 CCN(CC)S(=O)(=O)c1cccc(NC(=O)Nc2cccc(C(F)(F)F)c2)c1 nan
CHEMBL1339433 24195 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 3 4.4 CCN(CC)S(=O)(=O)c1cccc(NC(=O)Nc2cccc(C(F)(F)F)c2)c1 nan
646725 24200 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 7 0 7 4.9 CC(C)(C)n1nnnc1C(c1cccs1)N(Cc1ccccc1)Cc1ccco1 nan
CHEMBL1339493 24200 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 7 0 7 4.9 CC(C)(C)n1nnnc1C(c1cccs1)N(Cc1ccccc1)Cc1ccco1 nan
2083077 24203 None 5 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 0 8 5.2 COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccs4)o3)c2C)cc1 nan
CHEMBL1339536 24203 None 5 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 0 8 5.2 COc1ccc(-n2c(C)cc(C(=O)CSc3nnc(-c4cccs4)o3)c2C)cc1 nan
647616 24204 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 8 0 7 4.7 COc1cc(OC)cc(-c2nnc(SCC(=O)N(Cc3ccccc3)C(C)(C)C)o2)c1 nan
CHEMBL1339537 24204 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 8 0 7 4.7 COc1cc(OC)cc(-c2nnc(SCC(=O)N(Cc3ccccc3)C(C)(C)C)o2)c1 nan
2225909 24212 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 3 1 4 3.6 COc1ccccc1N1C(=O)NC(=O)/C(=C/c2ccc3c4c(cccc24)CC3)C1=O nan
CHEMBL1339581 24212 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 3 1 4 3.6 COc1ccccc1N1C(=O)NC(=O)/C(=C/c2ccc3c4c(cccc24)CC3)C1=O nan
1487304 24218 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 0 4 4.6 Cc1cc(C)c(S(=O)(=O)c2ccccc2C)c(SCC(C)C)n1 nan
CHEMBL1339640 24218 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 0 4 4.6 Cc1cc(C)c(S(=O)(=O)c2ccccc2C)c(SCC(C)C)n1 nan
2814239 24223 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 3 5.0 O=C(c1ccc(Oc2cc(Cl)cc(Cl)c2)o1)N1CCCCC1 nan
CHEMBL1339677 24223 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 3 5.0 O=C(c1ccc(Oc2cc(Cl)cc(Cl)c2)o1)N1CCCCC1 nan
1205156 24226 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 7 0 10 2.7 CCOC(=O)c1c(-c2ccccc2)nnn1-c1nc(OCC)nc(N2CCCCC2)n1 nan
CHEMBL1339697 24226 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 7 0 10 2.7 CCOC(=O)c1c(-c2ccccc2)nnn1-c1nc(OCC)nc(N2CCCCC2)n1 nan
2921061 24229 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 8 0 3 5.8 CC(=O)N(CCC(Cc1ccccc1)c1ccc2c(c1)OCO2)Cc1ccc(Cl)cc1 nan
CHEMBL1339728 24229 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 8 0 3 5.8 CC(=O)N(CCC(Cc1ccccc1)c1ccc2c(c1)OCO2)Cc1ccc(Cl)cc1 nan
2874375 24237 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 5 2 2 3.5 COc1ccc(CCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 nan
CHEMBL1339811 24237 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 5 2 2 3.5 COc1ccc(CCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 nan
935424 24241 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 4 1 5 4.0 CCOC(=O)c1sc(Nc2cccc(C)c2C)nc1C nan
CHEMBL1339854 24241 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 4 1 5 4.0 CCOC(=O)c1sc(Nc2cccc(C)c2C)nc1C nan
3583854 24246 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 7 1 9 4.2 CCCCCn1c(N)c(-c2nc3ccccc3s2)c2c([N+](=O)[O-])nn(CC)c(=O)c21 nan
CHEMBL1339872 24246 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 7 1 9 4.2 CCCCCn1c(N)c(-c2nc3ccccc3s2)c2c([N+](=O)[O-])nn(CC)c(=O)c21 nan
1105048 24272 None 18 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 0 3 4.0 COc1ccccc1N1CCN(C(=O)c2ccc(C(C)(C)C)cc2)CC1 nan
CHEMBL1340152 24272 None 18 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 0 3 4.0 COc1ccccc1N1CCN(C(=O)c2ccc(C(C)(C)C)cc2)CC1 nan
660296 24274 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 7 0 5 3.9 CCN(CC)C(=O)CSc1nc2ccccc2c(=O)n1CC1CCCCC1 nan
CHEMBL1340201 24274 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 7 0 5 3.9 CCN(CC)C(=O)CSc1nc2ccccc2c(=O)n1CC1CCCCC1 nan
660761 24321 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 3 0 7 4.5 Cc1cc(C)cc(-n2c3nc4ccccc4nc3c3c(=O)n(Cc4ccco4)cnc32)c1 nan
CHEMBL1340587 24321 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 3 0 7 4.5 Cc1cc(C)cc(-n2c3nc4ccccc4nc3c3c(=O)n(Cc4ccco4)cnc32)c1 nan
3215978 24332 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 6 1 3 4.7 Cc1ccc(CN(C(=O)C(F)(F)F)C(C(=O)NC2CCCCC2)c2ccco2)cc1 nan
CHEMBL1340690 24332 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 6 1 3 4.7 Cc1ccc(CN(C(=O)C(F)(F)F)C(C(=O)NC2CCCCC2)c2ccco2)cc1 nan
4247045 24343 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 4 1 4 4.9 CC1(C)Cc2c(cnn2-c2ccccc2)-c2c1c1ccccc1n2CC(O)CCl nan
CHEMBL1340792 24343 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 4 1 4 4.9 CC1(C)Cc2c(cnn2-c2ccccc2)-c2c1c1ccccc1n2CC(O)CCl nan
4142111 24354 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 6 1 5 5.1 O=C(NC12CC3CC(CC(C3)C1)C2)c1ccc(COc2ccc(Cl)cc2[N+](=O)[O-])o1 nan
CHEMBL1340893 24354 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 6 1 5 5.1 O=C(NC12CC3CC(CC(C3)C1)C2)c1ccc(COc2ccc(Cl)cc2[N+](=O)[O-])o1 nan
4029133 24370 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 6 3 7 3.6 Cc1cccc(Nc2nc(N)c([N+](=O)[O-])c(NCc3ccccc3)n2)c1 nan
CHEMBL1341064 24370 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 6 3 7 3.6 Cc1cccc(Nc2nc(N)c([N+](=O)[O-])c(NCc3ccccc3)n2)c1 nan
9551027 24372 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 3 0 3 4.2 CN1C(=O)/C(=C/c2cn(CC(=O)N3CCCCC3)c3ccccc23)c2ccccc21 nan
CHEMBL1341067 24372 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 3 0 3 4.2 CN1C(=O)/C(=C/c2cn(CC(=O)N3CCCCC3)c3ccccc23)c2ccccc21 nan
1898067 24377 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 3 3 5.4 Cc1ccc(NNC(=O)C(O)(c2cccc(C(F)(F)F)c2)c2cccc(C(F)(F)F)c2)cc1 nan
CHEMBL1341114 24377 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 3 3 5.4 Cc1ccc(NNC(=O)C(O)(c2cccc(C(F)(F)F)c2)c2cccc(C(F)(F)F)c2)cc1 nan
1004812 24404 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 6 1 2 4.8 O=C(NCc1ccccc1)c1cccc(COc2ccccc2Cl)c1 nan
CHEMBL1341289 24404 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 6 1 2 4.8 O=C(NCc1ccccc1)c1cccc(COc2ccccc2Cl)c1 nan
648560 24406 None 4 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 10 1 8 5.5 CCC(c1nnnn1CCc1ccccc1)N(Cc1ccco1)Cc1cc2c(C)ccc(C)c2nc1O nan
CHEMBL1341301 24406 None 4 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 10 1 8 5.5 CCC(c1nnnn1CCc1ccccc1)N(Cc1ccco1)Cc1cc2c(C)ccc(C)c2nc1O nan
3700887 24415 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 7 2 6 2.9 CC/C(NCc1cc(OC)cc(OC)c1)=C1/C(=O)NC(=O)N(C2CCCCC2)C1=O nan
CHEMBL1341384 24415 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 7 2 6 2.9 CC/C(NCc1cc(OC)cc(OC)c1)=C1/C(=O)NC(=O)N(C2CCCCC2)C1=O nan
1420362 24428 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 3 2 5 5.6 Cc1ccccc1NC(=O)c1sc2nc3c(c(-c4ccco4)c2c1N)CCCC3 nan
CHEMBL1341474 24428 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 3 2 5 5.6 Cc1ccccc1NC(=O)c1sc2nc3c(c(-c4ccco4)c2c1N)CCCC3 nan
1884940 24430 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 4 2 5 4.2 C=CCn1c(N)c(C(=O)Nc2ccc(C)c(C)c2)c2nc3ccccc3nc21 nan
CHEMBL1341502 24430 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 371 4 2 5 4.2 C=CCn1c(N)c(C(=O)Nc2ccc(C)c(C)c2)c2nc3ccccc3nc21 nan
3341317 24433 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 6 2 5 4.9 CC(NS(=O)(=O)c1cccc(Cl)c1)C(=O)Nc1ccc(-c2nc3ccccc3s2)cc1 nan
CHEMBL1341540 24433 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 6 2 5 4.9 CC(NS(=O)(=O)c1cccc(Cl)c1)C(=O)Nc1ccc(-c2nc3ccccc3s2)cc1 nan
2377631 24444 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 7 1 7 5.0 COc1cccc(-c2nn(-c3ccccc3)cc2C(=O)OCC(=O)Nc2ncc(Cl)cc2Cl)c1 nan
CHEMBL1341669 24444 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 7 1 7 5.0 COc1cccc(-c2nn(-c3ccccc3)cc2C(=O)OCC(=O)Nc2ncc(Cl)cc2Cl)c1 nan
4599426 24445 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 4 2 3 5.9 Cc1nn(Cc2ccc(Cl)cc2Cl)c(C)c1NC(=O)NC12CC3CC(CC(C3)C1)C2 nan
CHEMBL1341676 24445 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 4 2 3 5.9 Cc1nn(Cc2ccc(Cl)cc2Cl)c(C)c1NC(=O)NC12CC3CC(CC(C3)C1)C2 nan
5347285 24447 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 3 1 5 3.9 O=[N+]([O-])c1ccc(Cl)c(/C=C/c2cc(C(F)(F)F)nc(O)n2)c1 nan
CHEMBL1341697 24447 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 3 1 5 3.9 O=[N+]([O-])c1ccc(Cl)c(/C=C/c2cc(C(F)(F)F)nc(O)n2)c1 nan
665473 24460 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 1 6 4.0 Cc1cc(-c2nnc3n2N=C(c2ccc(-c4ccccc4)cc2)CS3)[nH]n1 nan
CHEMBL1341815 24460 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 1 6 4.0 Cc1cc(-c2nnc3n2N=C(c2ccc(-c4ccccc4)cc2)CS3)[nH]n1 nan
4896972 24463 None 6 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 5 1 6 4.6 Cc1ccc(-c2nn3c(C)nnc3c3ccccc23)cc1S(=O)(=O)NC(C)c1ccccc1 nan
CHEMBL1341841 24463 None 6 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 5 1 6 4.6 Cc1ccc(-c2nn3c(C)nnc3c3ccccc23)cc1S(=O)(=O)NC(C)c1ccccc1 nan
1527237 24477 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 4 0 4 5.0 COc1cc2c(cc1OC)C(c1ccc(-c3ccccc3Cl)o1)=NCC2 nan
CHEMBL1341936 24477 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 4 0 4 5.0 COc1cc2c(cc1OC)C(c1ccc(-c3ccccc3Cl)o1)=NCC2 nan
663900 24483 None 5 Human Functional pPotency = 5 5.0 -5 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1341981 24483 None 5 Human Functional pPotency = 5 5.0 -5 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
1534931 24487 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 6 4.0 O=C(Oc1c(CN2CCOCC2)cc(Cl)c2cccnc12)c1cccs1 nan
CHEMBL1341995 24487 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 6 4.0 O=C(Oc1c(CN2CCOCC2)cc(Cl)c2cccnc12)c1cccs1 nan
9550172 24491 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 9 0 7 3.9 CCCCCOc1ccc2oc(=O)c3c(c2c1)CCCN3C(=O)CN1CCCC(C(=O)OCC)C1 nan
CHEMBL1342047 24491 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 9 0 7 3.9 CCCCCOc1ccc2oc(=O)c3c(c2c1)CCCN3C(=O)CN1CCCC(C(=O)OCC)C1 nan
2973807 24516 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 481 4 0 6 5.2 COc1cccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCCCC4c4cccnc4)cc3n2)c1 nan
CHEMBL1342278 24516 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 481 4 0 6 5.2 COc1cccc(-c2cc(C(F)(F)F)n3nc(C(=O)N4CCCCC4c4cccnc4)cc3n2)c1 nan
1236977 24518 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 2 0 5 4.0 COC(=O)c1ccc(-n2nc(C(F)(F)F)c3c2-c2ccoc2CC3)cc1 nan
CHEMBL1342292 24518 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 2 0 5 4.0 COC(=O)c1ccc(-n2nc(C(F)(F)F)c3c2-c2ccoc2CC3)cc1 nan
2414249 24523 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 7 1 8 4.2 CCOC(=O)c1sc2nc(CSc3ccccc3)nc(N3CCC(C(N)=O)CC3)c2c1C nan
CHEMBL1342308 24523 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 7 1 8 4.2 CCOC(=O)c1sc2nc(CSc3ccccc3)nc(N3CCC(C(N)=O)CC3)c2c1C nan
1103630 24533 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 6 0 4 5.5 Cc1cc(-c2ccccc2)nc2cc(C(=O)N(Cc3ccccc3)Cc3ccccc3)nn12 nan
CHEMBL1342385 24533 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 6 0 4 5.5 Cc1cc(-c2ccccc2)nc2cc(C(=O)N(Cc3ccccc3)Cc3ccccc3)nn12 nan
16060493 24547 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 6 0 2 6.9 COc1ccc(/C=C/c2ccccc2)cc1[C@H]1[C@@H]2C=CCC[C@@]2(C)C(=O)N1Cc1ccccc1 nan
CHEMBL1342474 24547 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 6 0 2 6.9 COc1ccc(/C=C/c2ccccc2)cc1[C@H]1[C@@H]2C=CCC[C@@]2(C)C(=O)N1Cc1ccccc1 nan
5443591 24568 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 8 1 6 3.8 CCOC(=O)/C(C#N)=C\c1ccc(OCC(=O)Nc2ccc(C)cc2C)c(OC)c1 nan
CHEMBL1342661 24568 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 8 1 6 3.8 CCOC(=O)/C(C#N)=C\c1ccc(OCC(=O)Nc2ccc(C)cc2C)c(OC)c1 nan
3238294 24573 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 5 1 4 3.1 COc1ccccc1NC(=O)CN1CCN(c2ccc(Cl)cc2)CC1 nan
CHEMBL1342678 24573 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 5 1 4 3.1 COc1ccccc1NC(=O)CN1CCN(c2ccc(Cl)cc2)CC1 nan
1117123 24575 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 10 1 7 3.4 COc1ccc(N(CC(=O)NCc2ccccc2C)S(=O)(=O)c2ccccc2[N+](=O)[O-])c(OC)c1 nan
CHEMBL1342680 24575 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 10 1 7 3.4 COc1ccc(N(CC(=O)NCc2ccccc2C)S(=O)(=O)c2ccccc2[N+](=O)[O-])c(OC)c1 nan
6617879 24583 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 4 0 6 4.4 Cc1c(Cl)cccc1N1C(=O)C(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C1c1cccs1 nan
CHEMBL1342730 24583 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 467 4 0 6 4.4 Cc1c(Cl)cccc1N1C(=O)C(N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C1c1cccs1 nan
1180559 24584 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 0 5 4.2 O=S(=O)(c1ccccc1)c1nc(-c2ccccc2)oc1N1CCCCC1 nan
CHEMBL1342737 24584 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 0 5 4.2 O=S(=O)(c1ccccc1)c1nc(-c2ccccc2)oc1N1CCCCC1 nan
2990071 24591 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 3 0 6 3.0 CCOC(=O)N1CCN(c2nc(-c3ccco3)cc(C(F)(F)F)n2)CC1 nan
CHEMBL1342791 24591 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 3 0 6 3.0 CCOC(=O)N1CCN(c2nc(-c3ccco3)cc(C(F)(F)F)n2)CC1 nan
3846110 24601 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 5 0 7 4.8 C=CCn1c(SCc2csc(C)n2)nc2sc3c(c2c1=O)CCC(C)C3 nan
CHEMBL1342858 24601 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 5 0 7 4.8 C=CCn1c(SCc2csc(C)n2)nc2sc3c(c2c1=O)CCC(C)C3 nan
2957586 24609 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 5 2 4 4.5 O=C(Nc1ccc([N+](=O)[O-])cc1)Nc1ccc(OC(F)F)c(Cl)c1 nan
CHEMBL1342907 24609 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 5 2 4 4.5 O=C(Nc1ccc([N+](=O)[O-])cc1)Nc1ccc(OC(F)F)c(Cl)c1 nan
6404754 24616 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 3 0 3 5.1 Fc1ccc(Sc2cc(Cl)c(-c3ccccc3)nn2)cc1 nan
CHEMBL1342985 24616 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 316 3 0 3 5.1 Fc1ccc(Sc2cc(Cl)c(-c3ccccc3)nn2)cc1 nan
5309399 24618 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 5 1 6 3.2 Cc1ccc2oc(=O)c3cnn(CC(=O)NC4CCN(Cc5ccccc5)CC4)c3c2c1 nan
CHEMBL1343003 24618 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 5 1 6 3.2 Cc1ccc2oc(=O)c3cnn(CC(=O)NC4CCN(Cc5ccccc5)CC4)c3c2c1 nan
16195834 24625 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 528 9 1 5 4.3 O=C(C1=C[C@H](c2ccc(Br)cc2)C[C@H](OCCCCO)O1)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1343069 24625 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 528 9 1 5 4.3 O=C(C1=C[C@H](c2ccc(Br)cc2)C[C@H](OCCCCO)O1)N1CCN(Cc2ccccc2)CC1 nan
644662 24636 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 5 1 6 3.9 Cc1cc2nc(-c3ccc(SCC(=O)N4CCN(C(=O)c5ccco5)CC4)nc3)[nH]c2cc1C nan
CHEMBL1343178 24636 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 5 1 6 3.9 Cc1cc2nc(-c3ccc(SCC(=O)N4CCN(C(=O)c5ccco5)CC4)nc3)[nH]c2cc1C nan
6402475 24643 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 2 1 4 4.2 Nc1nc(-c2ccc(Cl)cc2)nnc1-c1ccc(Br)cc1 nan
CHEMBL1343242 24643 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 2 1 4 4.2 Nc1nc(-c2ccc(Cl)cc2)nnc1-c1ccc(Br)cc1 nan
3443305 24647 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 4 0 5 2.7 COC(=O)c1cc(C(=O)OC)n(Cc2ccc(C)cc2)c1C nan
CHEMBL1343276 24647 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 301 4 0 5 2.7 COC(=O)c1cc(C(=O)OC)n(Cc2ccc(C)cc2)c1C nan
16746279 24668 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 549 7 0 3 8.1 COc1ccc(-c2cccc(C3CC=CC4C3C(=O)N(Cc3ccccc3)C4c3ccc(OC)c(Cl)c3)c2)cc1 nan
CHEMBL1343422 24668 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 549 7 0 3 8.1 COc1ccc(-c2cccc(C3CC=CC4C3C(=O)N(Cc3ccccc3)C4c3ccc(OC)c(Cl)c3)c2)cc1 nan
1192556 24674 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 1 6 4.1 CCOC(=O)c1cnc2ccc(F)cc2c1Nc1ccc2c(c1)OCCO2 nan
CHEMBL1343481 24674 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 1 6 4.1 CCOC(=O)c1cnc2ccc(F)cc2c1Nc1ccc2c(c1)OCCO2 nan
16746380 24676 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 5 0 2 6.4 COc1ccc(-c2ccc(F)cc2)cc1[C@H]1[C@H]2C=CC[C@@H](C)[C@@H]2C(=O)N1Cc1ccccc1 nan
CHEMBL1343497 24676 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 441 5 0 2 6.4 COc1ccc(-c2ccc(F)cc2)cc1[C@H]1[C@H]2C=CC[C@@H](C)[C@@H]2C(=O)N1Cc1ccccc1 nan
647114 24684 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 0 5 3.5 Cn1c(SC2=CS(=O)(=O)c3ccccc32)nc2ccccc21 nan
CHEMBL1343568 24684 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 328 2 0 5 3.5 Cn1c(SC2=CS(=O)(=O)c3ccccc32)nc2ccccc21 nan
1841082 24689 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 5 0 7 3.8 CCCc1cc2c(=O)c(-c3ccc4c(c3)OCCO4)c(C)oc2cc1OS(C)(=O)=O nan
CHEMBL1343635 24689 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 5 0 7 3.8 CCCc1cc2c(=O)c(-c3ccc4c(c3)OCCO4)c(C)oc2cc1OS(C)(=O)=O nan
2082094 24694 None 1 Human Functional pPotency = 5 5.0 -3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 4 3.1 O=S(=O)(Nc1cccc2ncccc12)c1cccs1 nan
CHEMBL1343705 24694 None 1 Human Functional pPotency = 5 5.0 -3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 290 3 1 4 3.1 O=S(=O)(Nc1cccc2ncccc12)c1cccs1 nan
2304144 24702 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 4 1 2 4.8 Cc1ccc(C)c(NC(=O)c2ccccc2C(=O)c2ccccc2)c1 nan
CHEMBL1343753 24702 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 4 1 2 4.8 Cc1ccc(C)c(NC(=O)c2ccccc2C(=O)c2ccccc2)c1 nan
653965 24721 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 4 3.8 Cc1cc(C)c2nc(SCC(=O)N3CCCCC3)c(C#N)cc2c1 nan
CHEMBL1343941 24721 None 3 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 339 3 0 4 3.8 Cc1cc(C)c2nc(SCC(=O)N3CCCCC3)c(C#N)cc2c1 nan
3432973 24722 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 6 1 3 4.5 COCCN(C(S)=Nc1ccc(C)c(C)c1)C(C)c1ccco1 nan
CHEMBL1343946 24722 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 332 6 1 3 4.5 COCCN(C(S)=Nc1ccc(C)c(C)c1)C(C)c1ccco1 nan
1400670 24758 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 3 1 6 4.3 Clc1ccc(C2=Nn3c(nnc3-c3cc(-c4ccccc4)[nH]n3)SC2)cc1 nan
CHEMBL1344250 24758 None 5 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 3 1 6 4.3 Clc1ccc(C2=Nn3c(nnc3-c3cc(-c4ccccc4)[nH]n3)SC2)cc1 nan
5307769 24778 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 353 3 1 3 4.6 O=C1c2ccccc2C(Nc2ccc(F)c(Cl)c2)N1c1ccccn1 nan
CHEMBL1344436 24778 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 353 3 1 3 4.6 O=C1c2ccccc2C(Nc2ccc(F)c(Cl)c2)N1c1ccccn1 nan
661441 24786 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 233 3 1 3 2.8 CC(Sc1ccc2ccccc2n1)C(=O)O nan
CHEMBL1344527 24786 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 233 3 1 3 2.8 CC(Sc1ccc2ccccc2n1)C(=O)O nan
CHEMBL1530959 24786 None 5 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 233 3 1 3 2.8 CC(Sc1ccc2ccccc2n1)C(=O)O nan
2308590 24792 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 6 2 7 4.5 CCOC(=O)c1c(N)sc(C(O)(C(F)(F)F)C(F)(F)F)c1-c1ccc(OC)cc1OC nan
CHEMBL1344566 24792 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 6 2 7 4.5 CCOC(=O)c1c(N)sc(C(O)(C(F)(F)F)C(F)(F)F)c1-c1ccc(OC)cc1OC nan
2059984 24795 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 5 1 4 4.0 Cc1cc(CN2CCN(CCC#N)CC2)c(O)c(C2(C)CCCCC2)c1 nan
CHEMBL1344586 24795 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 5 1 4 4.0 Cc1cc(CN2CCN(CCC#N)CC2)c(O)c(C2(C)CCCCC2)c1 nan
656001 24800 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 0 4 5.2 CC(C)c1ccc(-c2noc(C3CCCN(C(=O)c4ccc(F)cc4F)C3)n2)cc1 nan
CHEMBL1344654 24800 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 4 0 4 5.2 CC(C)c1ccc(-c2noc(C3CCCN(C(=O)c4ccc(F)cc4F)C3)n2)cc1 nan
662321 24808 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 6 2 7 1.9 Cc1cccn2c(=O)c3cc(C(N)=S)c(=N)n(CCCOC(C)C)c3nc12 nan
CHEMBL1344730 24808 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 6 2 7 1.9 Cc1cccn2c(=O)c3cc(C(N)=S)c(=N)n(CCCOC(C)C)c3nc12 nan
618861 24809 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 0 1 3 4.7 c1ccc2c(c1)NC1(CCCCC1)n1c-2nc2ccccc21 nan
CHEMBL1344731 24809 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 0 1 3 4.7 c1ccc2c(c1)NC1(CCCCC1)n1c-2nc2ccccc21 nan
646364 24835 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 6 0 9 3.4 CC(C)C(c1nnnn1Cc1ccco1)N1CCN(c2nc3ccccc3s2)CC1 nan
CHEMBL1344911 24835 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 6 0 9 3.4 CC(C)C(c1nnnn1Cc1ccco1)N1CCN(c2nc3ccccc3s2)CC1 nan
2876123 24869 None 9 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 0 7 3.5 C=CCn1c2ccccc2c2nnc(SCN3C(=O)c4ccccc4C3=O)nc21 nan
CHEMBL1345233 24869 None 9 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 0 7 3.5 C=CCn1c2ccccc2c2nnc(SCN3C(=O)c4ccccc4C3=O)nc21 nan
5925441 24871 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 7 0 6 5.0 COc1ccc(C2CC(c3ccccc3OC(C)=O)=NN2C(=O)/C=C/c2ccccc2)cc1OC nan
CHEMBL1345253 24871 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 7 0 6 5.0 COc1ccc(C2CC(c3ccccc3OC(C)=O)=NN2C(=O)/C=C/c2ccccc2)cc1OC nan
4183264 24883 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 2 0 4 4.9 CC12CC(c3ccccc3O1)N(C(=O)c1ccco1)C(=S)N2c1ccc(F)cc1 nan
CHEMBL1345332 24883 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 2 0 4 4.9 CC12CC(c3ccccc3O1)N(C(=O)c1ccco1)C(=S)N2c1ccc(F)cc1 nan
5708012 24884 None 7 Human Functional pPotency = 5 5.0 -2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 5 0 3 5.3 COc1ccc(Cn2c(/C=C/c3ccccc3)nc3ccccc32)cc1 nan
CHEMBL1345334 24884 None 7 Human Functional pPotency = 5 5.0 -2 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 5 0 3 5.3 COc1ccc(Cn2c(/C=C/c3ccccc3)nc3ccccc32)cc1 nan
1247133 24894 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 6 0 3 4.0 CCCc1ccc(C(=O)N2CCN(c3ccccc3OCC)CC2)cc1 nan
CHEMBL1345436 24894 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 6 0 3 4.0 CCCc1ccc(C(=O)N2CCN(c3ccccc3OCC)CC2)cc1 nan
666154 24901 None 6 Human Functional pPotency = 5 5.0 3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 2 1 6 4.2 Cc1ccc(-n2nc(C)c3c(-c4cccs4)c(C#N)c(N)nc32)cc1 nan
CHEMBL1345487 24901 None 6 Human Functional pPotency = 5 5.0 3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 345 2 1 6 4.2 Cc1ccc(-n2nc(C)c3c(-c4cccs4)c(C#N)c(N)nc32)cc1 nan
2241256 24903 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 8 1 6 5.2 CCOc1ccc(NC(=O)CCSc2nc3c(c(CC)c2C#N)C(=O)CC(C)(C)C3)cc1 nan
CHEMBL1345510 24903 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 8 1 6 5.2 CCOc1ccc(NC(=O)CCSc2nc3c(c(CC)c2C#N)C(=O)CC(C)(C)C3)cc1 nan
3799510 24904 None 19 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 0 5 3.9 CC(Oc1ccc(Cl)cc1)c1ccnn1S(=O)(=O)c1ccccc1 nan
CHEMBL1345528 24904 None 19 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 5 0 5 3.9 CC(Oc1ccc(Cl)cc1)c1ccnn1S(=O)(=O)c1ccccc1 nan
16066590 24950 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 651 11 2 10 5.2 CC(C)CC(NC(=O)OC(C)(C)C)c1cn([C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)nn1 nan
CHEMBL1345953 24950 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 651 11 2 10 5.2 CC(C)CC(NC(=O)OC(C)(C)C)c1cn([C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)N2CCN(C(=O)OC(C)(C)C)CC2)nn1 nan
12004870 24958 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 8 1 4 5.4 COCCCn1c(-c2ccc(OC)cc2)cc(C(=O)NC2CCCCCCC2)c1C nan
CHEMBL1346004 24958 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 8 1 4 5.4 COCCCn1c(-c2ccc(OC)cc2)cc(C(=O)NC2CCCCCCC2)c1C nan
645264 24965 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 4 0 7 4.0 Cc1cccc(N2CCN(C(c3cccs3)c3nnnn3C(C)(C)C)CC2)c1C nan
CHEMBL1346069 24965 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 4 0 7 4.0 Cc1cccc(N2CCN(C(c3cccs3)c3nnnn3C(C)(C)C)CC2)c1C nan
16197109 24969 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 8 2 5 5.6 O=C(NCc1ccccc1)C1=C[C@@H](c2csc3ccccc23)C[C@@H](OCc2ccc(CO)cc2)O1 nan
CHEMBL1346106 24969 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 8 2 5 5.6 O=C(NCc1ccccc1)C1=C[C@@H](c2csc3ccccc23)C[C@@H](OCc2ccc(CO)cc2)O1 nan
135777933 24994 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 3 1 5 3.0 Cc1ccc(/C=C2\SC(NS(=O)(=O)c3cccs3)=NC2=O)cc1 nan
136722474 24994 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 3 1 5 3.0 Cc1ccc(/C=C2\SC(NS(=O)(=O)c3cccs3)=NC2=O)cc1 nan
146674364 24994 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 3 1 5 3.0 Cc1ccc(/C=C2\SC(NS(=O)(=O)c3cccs3)=NC2=O)cc1 nan
CHEMBL1346365 24994 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 3 1 5 3.0 Cc1ccc(/C=C2\SC(NS(=O)(=O)c3cccs3)=NC2=O)cc1 nan
1642415 24998 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 567 7 1 6 6.5 COc1ccc(-c2c(C(F)(F)F)oc3cc(OCC(=O)Nc4ccccc4C(F)(F)F)ccc3c2=O)cc1OC nan
CHEMBL1346421 24998 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 567 7 1 6 6.5 COc1ccc(-c2c(C(F)(F)F)oc3cc(OCC(=O)Nc4ccccc4C(F)(F)F)ccc3c2=O)cc1OC nan
666358 25017 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 8 4.3 COc1ccc(-c2oc3ncnc(NCCN4CCOCC4)c3c2-c2ccc(OC)cc2)cc1 nan
CHEMBL1346584 25017 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 8 4.3 COc1ccc(-c2oc3ncnc(NCCN4CCOCC4)c3c2-c2ccc(OC)cc2)cc1 nan
653059 25020 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 4 1 5 4.7 Cc1sc(NC(=O)c2ccco2)nc1-c1ccc2c(c1)CC(C)N2C(=O)C1CC1 nan
CHEMBL1346595 25020 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 4 1 5 4.7 Cc1sc(NC(=O)c2ccco2)nc1-c1ccc2c(c1)CC(C)N2C(=O)C1CC1 nan
3131058 25025 None 9 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 294 1 1 1 5.5 c1ccc2c(-c3c[nH]c4ccccc34)c3ccccc3nc2c1 nan
CHEMBL1346628 25025 None 9 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 294 1 1 1 5.5 c1ccc2c(-c3c[nH]c4ccccc34)c3ccccc3nc2c1 nan
1951150 25026 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 4 2 6 3.5 Cc1ccc(NC(=O)CSc2nc(N)c3cc4c(nc3n2)CCCC4)cc1 nan
CHEMBL1346630 25026 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 4 2 6 3.5 Cc1ccc(NC(=O)CSc2nc(N)c3cc4c(nc3n2)CCCC4)cc1 nan
1807334 25027 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 8 2 4 6.3 CCOc1cccc(CNc2ccc(O)cc2)c1OCc1ccc(Cl)cc1Cl nan
CHEMBL1346640 25027 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 8 2 4 6.3 CCOc1cccc(CNc2ccc(O)cc2)c1OCc1ccc(Cl)cc1Cl nan
1292688 25028 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 5 2 6 3.0 COc1ccc(NC(=O)c2ccc(-c3nn(C)c(=O)c4ccccc34)cc2)cc1C(N)=O nan
CHEMBL1346646 25028 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 5 2 6 3.0 COc1ccc(NC(=O)c2ccc(-c3nn(C)c(=O)c4ccccc34)cc2)cc1C(N)=O nan
2233210 25034 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 6 2 3 6.4 Cc1ccccc1NS(=O)(=O)c1cc(C(=O)Nc2ccccc2-c2ccccc2)ccc1Cl nan
CHEMBL1346672 25034 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 6 2 3 6.4 Cc1ccccc1NS(=O)(=O)c1cc(C(=O)Nc2ccccc2-c2ccccc2)ccc1Cl nan
1117371 25076 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 0 4 4.8 O=C(c1ccco1)N(Cc1ccc([N+](=O)[O-])cc1)c1ccc(Br)cc1 nan
CHEMBL1346973 25076 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 0 4 4.8 O=C(c1ccco1)N(Cc1ccc([N+](=O)[O-])cc1)c1ccc(Br)cc1 nan
9551034 25083 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 5 0 5 5.0 O=C(c1cc(-c2cccs2)on1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL1347023 25083 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 5 0 5 5.0 O=C(c1cc(-c2cccs2)on1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
656342 25092 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 0 0 3 4.0 O=c1c2c(nc3n1CCCCC3)-c1ccccc1CC21CCCC1 nan
CHEMBL1347109 25092 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 0 0 3 4.0 O=c1c2c(nc3n1CCCCC3)-c1ccccc1CC21CCCC1 nan
2115313 25096 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 8 1 6 6.2 O=C(CCCSc1ccccc1)Nc1nc(-c2ccco2)c(-c2ccco2)s1 nan
CHEMBL1347122 25096 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 8 1 6 6.2 O=C(CCCSc1ccccc1)Nc1nc(-c2ccco2)c(-c2ccco2)s1 nan
2567858 25102 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 6 1 8 3.7 Cc1cc(NC(=O)CSc2nc3cc(Cl)ccc3c(=O)n2Cc2ccco2)no1 nan
CHEMBL1347172 25102 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 6 1 8 3.7 Cc1cc(NC(=O)CSc2nc3cc(Cl)ccc3c(=O)n2Cc2ccco2)no1 nan
654502 25106 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 6 0 8 2.9 CC(C)CC(c1nnnn1C1CCCCC1)N1CCN(c2ncccn2)CC1 nan
CHEMBL1347184 25106 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 6 0 8 2.9 CC(C)CC(c1nnnn1C1CCCCC1)N1CCN(c2ncccn2)CC1 nan
1272711 25121 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 1 10 1.2 COc1ccc(-c2nnn(Cc3nc(N)nc(N4CCCCC4)n3)n2)cc1 nan
CHEMBL1347327 25121 None 8 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 5 1 10 1.2 COc1ccc(-c2nnn(Cc3nc(N)nc(N4CCCCC4)n3)n2)cc1 nan
2011053 25124 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 6 3.9 O=S(=O)(c1cccs1)N1CN(Cc2ccccc2)c2nc3ccccc3nc21 nan
CHEMBL1347358 25124 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 0 6 3.9 O=S(=O)(c1cccs1)N1CN(Cc2ccccc2)c2nc3ccccc3nc21 nan
12004598 25129 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 4 1 4 5.0 O=C1NN(c2ccccc2)C(=O)/C1=C/c1ccc(Sc2cccc3ccccc23)o1 nan
CHEMBL1347385 25129 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 4 1 4 5.0 O=C1NN(c2ccccc2)C(=O)/C1=C/c1ccc(Sc2cccc3ccccc23)o1 nan
2926312 25130 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 7 0 4 4.9 Cc1ccc(C(=O)C(OC(=O)COc2ccccc2C)c2ccccc2)cc1 nan
CHEMBL1347400 25130 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 7 0 4 4.9 Cc1ccc(C(=O)C(OC(=O)COc2ccccc2C)c2ccccc2)cc1 nan
2122092 25133 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 0 6 4.7 Cc1noc(C)c1COC(=O)c1ccccc1Sc1ccccc1C#N nan
CHEMBL1347430 25133 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 0 6 4.7 Cc1noc(C)c1COC(=O)c1ccccc1Sc1ccccc1C#N nan
917237 25139 None 5 Human Functional pPotency = 5 5.0 -7 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 1 1 3 4.0 Cc1ccc2[nH]c3c(N4CCc5ccccc5C4)ncnc3c2c1 nan
CHEMBL1347469 25139 None 5 Human Functional pPotency = 5 5.0 -7 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 314 1 1 3 4.0 Cc1ccc2[nH]c3c(N4CCc5ccccc5C4)ncnc3c2c1 nan
2108273 25143 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 0 9 4.8 CCc1cccc(CC)c1-n1c(SCc2cc(=O)n3ccsc3n2)nnc1-c1cccnc1 nan
CHEMBL1347492 25143 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 7 0 9 4.8 CCc1cccc(CC)c1-n1c(SCc2cc(=O)n3ccsc3n2)nnc1-c1cccnc1 nan
4601442 25164 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 7 2 4 4.1 Cc1ccc(NC(=O)CC2C(=O)N(Cc3ccccc3)C(=S)N2NC(=O)c2cccc(F)c2)c(C)c1 nan
CHEMBL1347649 25164 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 504 7 2 4 4.1 Cc1ccc(NC(=O)CC2C(=O)N(Cc3ccccc3)C(=S)N2NC(=O)c2cccc(F)c2)c(C)c1 nan
4879468 25176 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 4 4.2 CN(CC(=O)Nc1ccc([N+](=O)[O-])cc1Br)Cc1c(F)cccc1Cl nan
CHEMBL1347737 25176 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 1 4 4.2 CN(CC(=O)Nc1ccc([N+](=O)[O-])cc1Br)Cc1c(F)cccc1Cl nan
2345722 25182 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 7 1 6 5.8 CCc1cc2c(=O)c(-c3cnn(-c4ccccc4)c3)c(C)oc2cc1OCC(=O)Nc1cccc(C)c1 nan
CHEMBL1347795 25182 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 7 1 6 5.8 CCc1cc2c(=O)c(-c3cnn(-c4ccccc4)c3)c(C)oc2cc1OCC(=O)Nc1cccc(C)c1 nan
6220178 25183 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 7 1 4 4.4 O=C(/C=C/c1cn(CC(O)CN2CCCCC2)c2ccccc12)c1ccccc1 nan
CHEMBL1347799 25183 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 7 1 4 4.4 O=C(/C=C/c1cn(CC(O)CN2CCCCC2)c2ccccc12)c1ccccc1 nan
16196494 25195 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 11 4 7 3.5 CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OC(C)(C)C nan
CHEMBL1347895 25195 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 11 4 7 3.5 CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OC(C)(C)C nan
764683 25203 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 310 5 3 4 4.2 CCCc1ccc(Oc2c[nH]nc2-c2ccc(O)cc2O)cc1 nan
CHEMBL1347962 25203 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 310 5 3 4 4.2 CCCc1ccc(Oc2c[nH]nc2-c2ccc(O)cc2O)cc1 nan
5767688 25208 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 7 1 5 5.1 O=C(NCc1cccnc1)/C(=C/c1ccc(-c2ccc(Cl)cc2)o1)S(=O)(=O)c1ccccc1 nan
CHEMBL1348057 25208 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 7 1 5 5.1 O=C(NCc1cccnc1)/C(=C/c1ccc(-c2ccc(Cl)cc2)o1)S(=O)(=O)c1ccccc1 nan
657663 25212 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 9 3 6 3.9 N#Cc1c(NCCCO)nc(NCc2ccccc2)c2c1CCN(Cc1ccccc1)C2 nan
CHEMBL1348071 25212 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 9 3 6 3.9 N#Cc1c(NCCCO)nc(NCc2ccccc2)c2c1CCN(Cc1ccccc1)C2 nan
653521 25213 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 7 1 7 3.9 CC(C)(C)NC(=O)C(c1ccco1)N(C(=O)Cn1nnc(-c2ccc(F)cc2)n1)c1cccc(F)c1 nan
CHEMBL1348073 25213 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 494 7 1 7 3.9 CC(C)(C)NC(=O)C(c1ccco1)N(C(=O)Cn1nnc(-c2ccc(F)cc2)n1)c1cccc(F)c1 nan
4416036 25218 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 5 1 6 3.8 CCOc1ccc(Br)cc1C1C(C(=O)OC)=C(N)Oc2cc(N(C)C)ccc21 nan
CHEMBL1348135 25218 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 5 1 6 3.8 CCOc1ccc(Br)cc1C1C(C(=O)OC)=C(N)Oc2cc(N(C)C)ccc21 nan
3125194 25234 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 271 4 1 2 4.5 C=C(C)C1CCC(C)=C1COC(=O)Nc1ccccc1 nan
CHEMBL1348265 25234 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 271 4 1 2 4.5 C=C(C)C1CCC(C)=C1COC(=O)Nc1ccccc1 nan
16746496 25240 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 483 7 0 4 6.3 COc1ccc(-c2ccc(OC)c([C@H]3[C@H]4C=CC[C@@H](C)[C@@H]4C(=O)N3Cc3ccccc3)c2)cc1OC nan
CHEMBL1348313 25240 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 483 7 0 4 6.3 COc1ccc(-c2ccc(OC)c([C@H]3[C@H]4C=CC[C@@H](C)[C@@H]4C(=O)N3Cc3ccccc3)c2)cc1OC nan
4084262 25241 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 3 0 5 4.1 COc1ccc(-c2cc(C(F)(F)F)nc(-n3cc(Br)cn3)n2)cc1 nan
CHEMBL1348314 25241 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 398 3 0 5 4.1 COc1ccc(-c2cc(C(F)(F)F)nc(-n3cc(Br)cn3)n2)cc1 nan
3237243 25248 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 6 1 6 3.7 CCOC(=O)c1c(NC(=O)C(F)(OC)C(F)(F)F)sc(C(=O)N2CCCCC2)c1C nan
CHEMBL1348407 25248 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 6 1 6 3.7 CCOC(=O)c1c(NC(=O)C(F)(OC)C(F)(F)F)sc(C(=O)N2CCCCC2)c1C nan
1365629 25256 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 7 1 6 3.8 COc1ccc(/C=C2\SC(=O)N(CCC(=O)Nc3ccccc3)C2=O)cc1OC nan
CHEMBL1348497 25256 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 412 7 1 6 3.8 COc1ccc(/C=C2\SC(=O)N(CCC(=O)Nc3ccccc3)C2=O)cc1OC nan
16745355 25260 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 622 10 4 9 3.7 CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)c1[nH]cnc1C(=O)NC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)OC(C)(C)C nan
CHEMBL1348532 25260 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 622 10 4 9 3.7 CC(C)(C)OC(=O)NCCCC[C@H](NC(=O)c1[nH]cnc1C(=O)NC1CCN(C(=O)OC(C)(C)C)CC1)C(=O)OC(C)(C)C nan
3810543 25285 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 7 2.5 Cc1nc(N2CCOCC2)nc(Oc2ccccc2F)c1[N+](=O)[O-] nan
CHEMBL1348825 25285 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 7 2.5 Cc1nc(N2CCOCC2)nc(Oc2ccccc2F)c1[N+](=O)[O-] nan
1256964 25288 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 4 1 4 5.1 O=C(NCc1cccs1)c1cc(-c2ccccn2)nc2ccc(Br)cc12 nan
CHEMBL1348841 25288 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 4 1 4 5.1 O=C(NCc1cccs1)c1cc(-c2ccccn2)nc2ccc(Br)cc12 nan
3219077 25298 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 5 1 4 6.1 Cc1ccc2cc3cc(C(=O)N(CC(=O)NC4CCCC4)c4cccc(C)c4C)sc3nc2c1 nan
CHEMBL1348922 25298 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 5 1 4 6.1 Cc1ccc2cc3cc(C(=O)N(CC(=O)NC4CCCC4)c4cccc(C)c4C)sc3nc2c1 nan
4890486 25300 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 5 2 7 3.2 CC(O)CNc1nc2sc3c(c2c(=O)n1Cc1ccco1)CCCCC3 nan
CHEMBL1348935 25300 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 373 5 2 7 3.2 CC(O)CNc1nc2sc3c(c2c(=O)n1Cc1ccco1)CCCCC3 nan
4302188 25301 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 6 1 5 3.4 CCOC(=O)C1(C)C=C(Nc2cccc(OC)c2)C(=O)N1c1ccccc1 nan
CHEMBL1348938 25301 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 6 1 5 3.4 CCOC(=O)C1(C)C=C(Nc2cccc(OC)c2)C(=O)N1c1ccccc1 nan
661059 25305 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 2 1 4 4.1 Cc1ccc(-c2cc(-c3ccc(C)o3)nc(N)c2C#N)cc1 nan
CHEMBL1348969 25305 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 289 2 1 4 4.1 Cc1ccc(-c2cc(-c3ccc(C)o3)nc(N)c2C#N)cc1 nan
1842616 25323 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 2 4.3 Cc1ccc(C(=O)Nc2ccccc2C(=O)N2CCCCCC2)cc1 nan
CHEMBL1349097 25323 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 336 3 1 2 4.3 Cc1ccc(C(=O)Nc2ccccc2C(=O)N2CCCCCC2)cc1 nan
1222105 25336 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 6 0 6 3.5 O=C(c1ccc(Cn2cc(Cl)c([N+](=O)[O-])n2)cc1)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1349189 25336 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 6 0 6 3.5 O=C(c1ccc(Cn2cc(Cl)c([N+](=O)[O-])n2)cc1)N1CCN(Cc2ccccc2)CC1 nan
3236309 25361 None 1 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 6 0 7 3.8 CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(c2ccccc2OC)CC1 nan
CHEMBL1349403 25361 None 1 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 6 0 7 3.8 CCOC(=O)c1cnc2c(OC)cccc2c1N1CCN(c2ccccc2OC)CC1 nan
659411 25363 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 6 0 8 2.4 Cn1c(=O)c2c(nc(N3CCN(c4ccccc4)CC3)n2CCCc2ccccc2)n(C)c1=O nan
CHEMBL1349407 25363 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 6 0 8 2.4 Cn1c(=O)c2c(nc(N3CCN(c4ccccc4)CC3)n2CCCc2ccccc2)n(C)c1=O nan
1362259 25364 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 4 0 5 6.6 COc1ccc(N2C3=C(C(=O)CC(C)(C)C3)C(c3ccccc3OC)C3=C2CC(C)(C)CC3=O)cc1 nan
CHEMBL1349412 25364 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 485 4 0 5 6.6 COc1ccc(N2C3=C(C(=O)CC(C)(C)C3)C(c3ccccc3OC)C3=C2CC(C)(C)CC3=O)cc1 nan
654235 25378 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 9 0 9 2.9 COc1ccc(OC)c(C(c2nnnn2CCC(C)C)N2CCN(C(=O)c3ccco3)CC2)c1 nan
CHEMBL1349521 25378 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 9 0 9 2.9 COc1ccc(OC)c(C(c2nnnn2CCC(C)C)N2CCN(C(=O)c3ccco3)CC2)c1 nan
2972359 25385 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 3 1 3 4.4 O=C(c1ccccc1)N1N=C(c2ccccc2)CC1c1ccccc1O nan
CHEMBL1349593 25385 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 3 1 3 4.4 O=C(c1ccccc1)N1N=C(c2ccccc2)CC1c1ccccc1O nan
3238670 25388 None 5 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 1 7 5.6 Cc1ccccc1CSc1nc2n(n1)C(c1cccs1)C1=C(O)CCCC1=N2 nan
CHEMBL1349610 25388 None 5 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 4 1 7 5.6 Cc1ccccc1CSc1nc2n(n1)C(c1cccs1)C1=C(O)CCCC1=N2 nan
1293322 25412 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 5 1 3 3.5 CS(=O)(=O)N(CC(=O)Nc1ccc(Cl)c(Cl)c1)C1CCCCC1 nan
CHEMBL1349807 25412 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 5 1 3 3.5 CS(=O)(=O)N(CC(=O)Nc1ccc(Cl)c(Cl)c1)C1CCCCC1 nan
5307417 25433 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 1 5 2.6 COCCOC(=O)c1[nH]c2c(c1C)C(=O)CC(c1ccco1)C2 nan
CHEMBL1350028 25433 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 1 5 2.6 COCCOC(=O)c1[nH]c2c(c1C)C(=O)CC(c1ccco1)C2 nan
732210 25434 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 285 4 1 4 4.5 CCOC(=O)c1c(C)[nH]c(N=Nc2ccccc2C)c1C nan
CHEMBL1350032 25434 None 14 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 285 4 1 4 4.5 CCOC(=O)c1c(C)[nH]c(N=Nc2ccccc2C)c1C nan
657782 25437 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 2 0 5 3.7 Cc1nc(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(C#N)c2c1COC(C)(C)C2 nan
CHEMBL1350047 25437 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 2 0 5 3.7 Cc1nc(N2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(C#N)c2c1COC(C)(C)C2 nan
664687 25449 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 8 2 7 3.8 CC(C)OCCCNC(=O)c1c(N)n(Cc2cccs2)c2nc3ccccc3nc12 nan
CHEMBL1350167 25449 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 423 8 2 7 3.8 CC(C)OCCCNC(=O)c1c(N)n(Cc2cccs2)c2nc3ccccc3nc12 nan
2375678 25450 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 347 2 2 4 3.9 N#Cc1c(NC(=S)NC(=O)C2CCCC2)sc2c1CCCCC2 nan
CHEMBL1350169 25450 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 347 2 2 4 3.9 N#Cc1c(NC(=S)NC(=O)C2CCCC2)sc2c1CCCCC2 nan
3197301 25462 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 586 11 2 7 5.2 COc1ccc(C(C(=O)NC2CCCCC2)N(C(=O)CCCC(=O)Nc2ccccn2)c2ccc3c(c2)OCCO3)cc1 nan
CHEMBL1350243 25462 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 586 11 2 7 5.2 COc1ccc(C(C(=O)NC2CCCCC2)N(C(=O)CCCC(=O)Nc2ccccn2)c2ccc3c(c2)OCCO3)cc1 nan
1439972 25463 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 7 0 3 5.5 COc1ccc(CCN(Cc2cc3cc(C)cc(C)c3nc2Cl)C(=O)C2CC2)cc1 nan
CHEMBL1350256 25463 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 7 0 3 5.5 COc1ccc(CCN(Cc2cc3cc(C)cc(C)c3nc2Cl)C(=O)C2CC2)cc1 nan
662765 25466 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 4 2 5 3.4 CCOC(=O)c1ccc(N2C(=O)c3[nH]nc(C)c3C2c2ccc(O)cc2)cc1 nan
CHEMBL1350275 25466 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 4 2 5 3.4 CCOC(=O)c1ccc(N2C(=O)c3[nH]nc(C)c3C2c2ccc(O)cc2)cc1 nan
11834531 25469 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 2 0 2 5.5 CN1C2CCC1/C(=C\c1ccccc1Cl)C(=O)/C2=C\c1ccccc1Cl nan
CHEMBL1350295 25469 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 2 0 2 5.5 CN1C2CCC1/C(=C\c1ccccc1Cl)C(=O)/C2=C\c1ccccc1Cl nan
6404160 25475 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 4 0 5 3.8 Cc1ccc(-c2nnc(N3CCCCC3)c3ccccc23)cc1S(=O)(=O)N(C)C nan
CHEMBL1350352 25475 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 4 0 5 3.8 Cc1ccc(-c2nnc(N3CCCCC3)c3ccccc23)cc1S(=O)(=O)N(C)C nan
3190117 25481 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 9 1 6 3.6 CC(C)CCNC(=O)CN(C(=O)Cn1nnc(-c2ccccc2F)n1)c1cccc2c1CCCC2 nan
CHEMBL1350410 25481 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 9 1 6 3.6 CC(C)CCNC(=O)CN(C(=O)Cn1nnc(-c2ccccc2F)n1)c1cccc2c1CCCC2 nan
2081076 25484 None 13 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 2 1 5 3.3 O=c1c2c3c(sc2[nH]c(=S)n1Cc1ccco1)CCC3 nan
CHEMBL1350435 25484 None 13 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 2 1 5 3.3 O=c1c2c3c(sc2[nH]c(=S)n1Cc1ccco1)CCC3 nan
3910054 25488 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 7 4.2 CCC(C)OC(=O)c1c(N)n(Cc2cccs2)c2nc3ccccc3nc12 nan
CHEMBL1350491 25488 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 7 4.2 CCC(C)OC(=O)c1c(N)n(Cc2cccs2)c2nc3ccccc3nc12 nan
2214216 25490 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 281 3 0 3 3.7 O=C(OCc1ccc(Cl)c(Cl)c1)c1ccccn1 nan
CHEMBL1350523 25490 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 281 3 0 3 3.7 O=C(OCc1ccc(Cl)c(Cl)c1)c1ccccn1 nan
665727 25495 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 5 0 7 4.1 COc1ccccc1-c1nnc2sc(COc3ccc(Cl)cc3)nn12 nan
CHEMBL1350579 25495 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 5 0 7 4.1 COc1ccccc1-c1nnc2sc(COc3ccc(Cl)cc3)nn12 nan
15945154 25496 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 5 1 5 4.7 O=C(CSc1nc[nH]n1)N1N=C2/C(=C/c3ccccc3)CCCC2C1c1ccccc1 nan
CHEMBL1350580 25496 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 5 1 5 4.7 O=C(CSc1nc[nH]n1)N1N=C2/C(=C/c3ccccc3)CCCC2C1c1ccccc1 nan
1296926 25524 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 4 2 2 5.3 Cc1ccc(OC(F)F)c(NC(=O)Nc2cccc(C(F)(F)F)c2)c1 nan
CHEMBL1350778 25524 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 360 4 2 2 5.3 Cc1ccc(OC(F)F)c(NC(=O)Nc2cccc(C(F)(F)F)c2)c1 nan
1246228 25526 None 8 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 310 2 1 4 4.5 Cc1sc(NC(=O)c2oc3ccccc3c2C)c(C#N)c1C nan
CHEMBL1350806 25526 None 8 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 310 2 1 4 4.5 Cc1sc(NC(=O)c2oc3ccccc3c2C)c(C#N)c1C nan
2237563 25533 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 8 3 4 4.3 C=CCNC(=O)c1ccccc1NC(=O)c1ccc(Cl)c(S(=O)(=O)Nc2ccccc2)c1 nan
CHEMBL1350854 25533 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 8 3 4 4.3 C=CCNC(=O)c1ccccc1NC(=O)c1ccc(Cl)c(S(=O)(=O)Nc2ccccc2)c1 nan
731858 25542 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 3 1 2 3.3 COc1ccc(NC(=O)C=C(C)C)cc1Cl nan
CHEMBL1350956 25542 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 239 3 1 2 3.3 COc1ccc(NC(=O)C=C(C)C)cc1Cl nan
1977613 25544 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 2 4 6.8 O=C(O)c1ccccc1-c1ccccc1C(=O)Nc1ccc(-c2nc3cc(Cl)ccc3o2)cc1 nan
CHEMBL1350958 25544 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 5 2 4 6.8 O=C(O)c1ccccc1-c1ccccc1C(=O)Nc1ccc(-c2nc3cc(Cl)ccc3o2)cc1 nan
660268 25551 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 7 0 7 3.3 C=CCOC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1351054 25551 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 7 0 7 3.3 C=CCOC(=O)C(C#N)c1nc2ccccc2nc1N1CCN(Cc2ccccc2)CC1 nan
4132205 25562 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 8 1 6 5.0 Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCN2CCCCC2)cc1Cl nan
CHEMBL1351106 25562 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 484 8 1 6 5.0 Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCN2CCCCC2)cc1Cl nan
2309203 25568 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 7 2 4 4.3 O=C(NCCCCNC(=O)c1ccc(Br)s1)c1ccc(Br)s1 nan
CHEMBL1351160 25568 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 7 2 4 4.3 O=C(NCCCCNC(=O)c1ccc(Br)s1)c1ccc(Br)s1 nan
3754375 25572 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 0 8 5.7 C=CCn1c(SCc2cccc(C)c2)nnc1-c1csc(-n2nc(C)cc2C(F)(F)F)n1 nan
CHEMBL1351184 25572 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 7 0 8 5.7 C=CCn1c(SCc2cccc(C)c2)nnc1-c1csc(-n2nc(C)cc2C(F)(F)F)n1 nan
2831459 25582 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 5 3 2 5.8 O=C(Cc1cccc2ccccc12)NC(NC(=S)Nc1ccccc1Cl)C(Cl)(Cl)Cl nan
CHEMBL1351293 25582 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 5 3 2 5.8 O=C(Cc1cccc2ccccc12)NC(NC(=S)Nc1ccccc1Cl)C(Cl)(Cl)Cl nan
710947 25611 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 2 0 4 3.9 CC1CCN(c2nc(-c3ccncc3)nc3ccccc23)CC1 nan
CHEMBL1351516 25611 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 2 0 4 3.9 CC1CCN(c2nc(-c3ccncc3)nc3ccccc23)CC1 nan
2998445 25618 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 1 1 3 2.8 CN1C=CC=C/C1=C(\C#N)c1nc2ccccc2[nH]1 nan
CHEMBL1351598 25618 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 248 1 1 3 2.8 CN1C=CC=C/C1=C(\C#N)c1nc2ccccc2[nH]1 nan
1905581 25619 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 369 3 0 4 3.7 CCCCN1C(=O)/C(=C2\SC(N3CCCCC3)=NC2=O)c2ccccc21 nan
CHEMBL1351610 25619 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 369 3 0 4 3.7 CCCCN1C(=O)/C(=C2\SC(N3CCCCC3)=NC2=O)c2ccccc21 nan
4615252 25620 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 0 6 5.6 Cc1ccc(C)c(CSc2nnc(-c3cccs3)n2Cc2ccco2)c1 nan
CHEMBL1351617 25620 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 0 6 5.6 Cc1ccc(C)c(CSc2nnc(-c3cccs3)n2Cc2ccco2)c1 nan
3188642 25634 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 3 0 5 4.7 Cc1ccc(-c2nnn(C(C)C(=O)N3c4ccccc4CCc4ccccc43)n2)cc1 nan
CHEMBL1351684 25634 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 3 0 5 4.7 Cc1ccc(-c2nnn(C(C)C(=O)N3c4ccccc4CCc4ccccc43)n2)cc1 nan
2931989 25642 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 5 3.5 COC(=O)c1c(-c2ccc(F)cc2)csc1NC(=O)C1CCCO1 nan
CHEMBL1351738 25642 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 5 3.5 COC(=O)c1c(-c2ccc(F)cc2)csc1NC(=O)C1CCCO1 nan
135425014 25648 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 3 3 5 1.0 N=C(CC1CC(=O)NC(=O)C1)C1=C(O)CCCC1=O nan
CHEMBL1351858 25648 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 264 3 3 5 1.0 N=C(CC1CC(=O)NC(=O)C1)C1=C(O)CCCC1=O nan
664621 25650 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 5 1 6 3.4 N#Cc1cc2c(nc1SCC(=O)NCc1ccc3c(c1)OCO3)CCCCC2 nan
CHEMBL1351861 25650 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 395 5 1 6 3.4 N#Cc1cc2c(nc1SCC(=O)NCc1ccc3c(c1)OCO3)CCCCC2 nan
135449268 25665 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 6 1 4 4.1 CCCC(=O)C1=C(Nc2ccccc2OC)CC(C)(C)CC1=O nan
CHEMBL1352013 25665 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 6 1 4 4.1 CCCC(=O)C1=C(Nc2ccccc2OC)CC(C)(C)CC1=O nan
3228219 25666 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 6 2.8 Cc1nc(N2CCC(C)CC2)c2nnn(Cc3ccccc3)c2n1 nan
CHEMBL1352014 25666 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 6 2.8 Cc1nc(N2CCC(C)CC2)c2nnn(Cc3ccccc3)c2n1 nan
1116954 25677 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 9 2 8 3.8 CCNc1nc(NC(C)C)nc(N(C#N)CCOc2ccc(Cl)cc2Cl)n1 nan
CHEMBL1352138 25677 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 9 2 8 3.8 CCNc1nc(NC(C)C)nc(N(C#N)CCOc2ccc(Cl)cc2Cl)n1 nan
3930624 25681 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 8 2 6 3.2 CC(C)CC(NC(=O)c1ccc(Cl)cc1)C(=O)OCC(=O)c1ccc2c(c1)NC(=O)CO2 nan
CHEMBL1352168 25681 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 8 2 6 3.2 CC(C)CC(NC(=O)c1ccc(Cl)cc1)C(=O)OCC(=O)c1ccc2c(c1)NC(=O)CO2 nan
5782370 25683 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 8 1 5 5.1 CCC(C)c1ccc(N2C(=O)NC(=O)/C(=C/c3cccn3CCOc3ccc(C)cc3)C2=O)cc1 nan
CHEMBL1352173 25683 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 471 8 1 5 5.1 CCC(C)c1ccc(N2C(=O)NC(=O)/C(=C/c3cccn3CCOc3ccc(C)cc3)C2=O)cc1 nan
3238591 25686 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 1 8 4.0 CCOC(=O)c1sc(Nc2nc3c(OC)cccc3s2)nc1C nan
CHEMBL1352200 25686 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 5 1 8 4.0 CCOC(=O)c1sc(Nc2nc3c(OC)cccc3s2)nc1C nan
16682572 25692 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 1 3 4.0 NC1=NC[C@H](Cc2ccccc2)N1CCCCC1CCCCC1 nan
CHEMBL1352234 25692 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 313 7 1 3 4.0 NC1=NC[C@H](Cc2ccccc2)N1CCCCC1CCCCC1 nan
2951842 25711 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 6 0 4 4.3 CC1CCN(S(=O)(=O)c2cccc(C(=O)N(Cc3ccccc3)c3ccccn3)c2)CC1 nan
CHEMBL1352345 25711 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 6 0 4 4.3 CC1CCN(S(=O)(=O)c2cccc(C(=O)N(Cc3ccccc3)c3ccccn3)c2)CC1 nan
6324568 25712 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 1 5 4.3 Cc1ccc2nc(O)c3cc(C(=O)N(C)Cc4ccco4)sc3c2c1 nan
CHEMBL1352349 25712 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 3 1 5 4.3 Cc1ccc2nc(O)c3cc(C(=O)N(C)Cc4ccco4)sc3c2c1 nan
135498061 25762 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 386 5 1 6 4.3 CCOC(=O)C1=C(Nc2ccc(Cl)cc2)S/C(=C\c2ccccn2)C1=O nan
CHEMBL1352714 25762 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 386 5 1 6 4.3 CCOC(=O)C1=C(Nc2ccc(Cl)cc2)S/C(=C\c2ccccn2)C1=O nan
1717753 25784 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 1 7 5.6 CCc1nnc(NC(=O)CSc2nc(-c3ccccc3)cc(-c3ccc(F)cc3)c2C#N)s1 nan
CHEMBL1352902 25784 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 475 7 1 7 5.6 CCc1nnc(NC(=O)CSc2nc(-c3ccccc3)cc(-c3ccc(F)cc3)c2C#N)s1 nan
3934007 25790 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 3 0 5 3.2 CCOC(=O)C1=C(C)N=C(SC)N(C)C1c1ccccc1 nan
CHEMBL1352951 25790 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 3 0 5 3.2 CCOC(=O)C1=C(C)N=C(SC)N(C)C1c1ccccc1 nan
2607834 25808 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 7 0 6 4.3 CCN(CC)C(=O)CSC1=N/C(=C/c2ccco2)C(=O)N1c1ccc(OC)c(Cl)c1 nan
CHEMBL1353130 25808 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 447 7 0 6 4.3 CCN(CC)C(=O)CSC1=N/C(=C/c2ccco2)C(=O)N1c1ccc(OC)c(Cl)c1 nan
2764721 25819 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 1 5 4.0 COC(=O)c1sccc1-c1ccc(C(=O)Nc2ccccc2)o1 nan
CHEMBL1353188 25819 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 1 5 4.0 COC(=O)c1sccc1-c1ccc(C(=O)Nc2ccccc2)o1 nan
2999428 25821 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 5 1 5 3.2 CN(C)CCCNc1c2c(c(C#N)c3nc4ccccc4n13)CCC2 nan
CHEMBL1353199 25821 None 7 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 333 5 1 5 3.2 CN(C)CCCNc1c2c(c(C#N)c3nc4ccccc4n13)CCC2 nan
5775810 25827 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 5 0 4 5.0 CC(=O)Oc1ccccc1C1=NN(C(=O)/C=C/c2ccccc2)C(c2ccccc2)C1 nan
CHEMBL1353219 25827 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 5 0 4 5.0 CC(=O)Oc1ccccc1C1=NN(C(=O)/C=C/c2ccccc2)C(c2ccccc2)C1 nan
3238005 25828 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 5 1 6 4.1 COc1cccc(-c2nn(C)c3sc(C(=O)NCc4ccc(C)o4)cc23)c1 nan
CHEMBL1353220 25828 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 5 1 6 4.1 COc1cccc(-c2nn(C)c3sc(C(=O)NCc4ccc(C)o4)cc23)c1 nan
1838181 25841 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 8 1 11 3.8 CCCCSc1nc2ccc(Nc3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2s1 nan
CHEMBL1353293 25841 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 8 1 11 3.8 CCCCSc1nc2ccc(Nc3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2s1 nan
645578 25845 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 4 0 6 4.2 Cc1ccc2c(c1)nnn2C1CCN(S(=O)(=O)c2ccc(C(=O)N3C(C)CCCC3C)cc2)CC1 nan
CHEMBL1353317 25845 None 0 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 4 0 6 4.2 Cc1ccc2c(c1)nnn2C1CCN(S(=O)(=O)c2ccc(C(=O)N3C(C)CCCC3C)cc2)CC1 nan
3120512 25870 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 1 0 3 5.0 CC1(C)OC(=O)N(c2ccccc2)C12C=Cc1cc(Br)ccc1O2 nan
CHEMBL1353504 25870 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 1 0 3 5.0 CC1(C)OC(=O)N(c2ccccc2)C12C=Cc1cc(Br)ccc1O2 nan
1068317 25890 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 6 1 7 4.3 COc1ccc(-c2nn(-c3ccccc3)cc2C(=O)Nc2nccs2)cc1OC nan
CHEMBL1353619 25890 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 6 1 7 4.3 COc1ccc(-c2nn(-c3ccccc3)cc2C(=O)Nc2nccs2)cc1OC nan
2375058 25899 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 4 5.3 CCOc1ccc(N(C(=O)c2ccccc2Cl)C2=NC(C)(C)CS2)cc1 nan
CHEMBL1353719 25899 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 4 0 4 5.3 CCOc1ccc(N(C(=O)c2ccccc2Cl)C2=NC(C)(C)CS2)cc1 nan
15621812 25903 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 514 5 1 8 4.8 COc1cc([C@@H]2c3cc4c(cc3[C@@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O[Si](C)(C)C(C)(C)C nan
CHEMBL1353750 25903 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 514 5 1 8 4.8 COc1cc([C@@H]2c3cc4c(cc3[C@@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1O[Si](C)(C)C(C)(C)C nan
4024466 25905 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 11 1 4 5.9 COc1ccc(CNCCC(c2ccc(F)cc2)c2ccc(OC(C)C)cc2)cc1OC nan
CHEMBL1353760 25905 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 437 11 1 4 5.9 COc1ccc(CNCCC(c2ccc(F)cc2)c2ccc(OC(C)C)cc2)cc1OC nan
664586 25915 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 1 6 3.3 Cc1nn(-c2ccccc2)c2c1C1(C(=O)N(C(C)C)c3ccccc31)C(C#N)=C(N)O2 nan
CHEMBL1353816 25915 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 1 6 3.3 Cc1nn(-c2ccccc2)c2c1C1(C(=O)N(C(C)C)c3ccccc31)C(C#N)=C(N)O2 nan
1450278 25922 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 4 1 6 4.2 Cc1cc(C)c2cc(C#N)c(SCC(=O)Nc3ccc4c(c3)OCO4)nc2c1 nan
CHEMBL1353861 25922 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 4 1 6 4.2 Cc1cc(C)c2cc(C#N)c(SCC(=O)Nc3ccc4c(c3)OCO4)nc2c1 nan
606613 25935 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 194 2 0 5 1.5 CCSc1cc(C)nc2ncnn12 nan
CHEMBL1353966 25935 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 194 2 0 5 1.5 CCSc1cc(C)nc2ncnn12 nan
3225093 25946 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 0 3 5.3 O=C(c1cc2sccc2n1Cc1ccccc1)N1CCCc2ccccc21 nan
CHEMBL1354043 25946 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 372 3 0 3 5.3 O=C(c1cc2sccc2n1Cc1ccccc1)N1CCCc2ccccc21 nan
9550256 25948 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 5 0 5 4.6 CC1CC(C)CN(CC(=O)N2CCCc3c2c(=O)oc2ccc(OCc4ccccc4)cc32)C1 nan
CHEMBL1354056 25948 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 5 0 5 4.6 CC1CC(C)CN(CC(=O)N2CCCc3c2c(=O)oc2ccc(OCc4ccccc4)cc32)C1 nan
661816 25949 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 0 6 4.5 N#CCSc1nc2c(c(=O)n1Cc1ccco1)C1(CCCC1)Cc1ccccc1-2 nan
CHEMBL1354069 25949 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 0 6 4.5 N#CCSc1nc2c(c(=O)n1Cc1ccco1)C1(CCCC1)Cc1ccccc1-2 nan
16745681 26282 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 8 0 7 6.4 CCCCC1=CC2=C(c3ccco3)C(=O)C(C)(OC(=O)c3ccc(OC)cc3)C(=O)C2=CN1C1CCCCC1 nan
CHEMBL1358243 26282 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 529 8 0 7 6.4 CCCCC1=CC2=C(c3ccco3)C(=O)C(C)(OC(=O)c3ccc(OC)cc3)C(=O)C2=CN1C1CCCCC1 nan
3799752 26339 None 5 Human Functional pPotency = 5 5.0 3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 6 2 6 2.4 COc1ccc(OC)c(N/C=C2/C(=O)NC(=S)N(Cc3ccccc3)C2=O)c1 nan
CHEMBL1358861 26339 None 5 Human Functional pPotency = 5 5.0 3 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 6 2 6 2.4 COc1ccc(OC)c(N/C=C2/C(=O)NC(=S)N(Cc3ccccc3)C2=O)c1 nan
7206282 26343 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 6 1 7 3.8 CC(=O)c1ccc(NC(=O)CSc2ccc(-c3ccc4c(c3)OCO4)nn2)cc1 nan
CHEMBL1358911 26343 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 6 1 7 3.8 CC(=O)c1ccc(NC(=O)CSc2ccc(-c3ccc4c(c3)OCO4)nn2)cc1 nan
16197003 26357 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 7 2 4 3.8 O=C(NC1CC1)C1=C[C@H](C2CCCCC2)C[C@H](OCc2ccc(CO)cc2)O1 nan
CHEMBL1359024 26357 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 7 2 4 3.8 O=C(NC1CC1)C1=C[C@H](C2CCCCC2)C[C@H](OCc2ccc(CO)cc2)O1 nan
3242607 26360 None 1 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 3 0 4 3.3 O=C(C1CCCN(S(=O)(=O)c2ccc(Br)s2)C1)N1CCCCCC1 nan
CHEMBL1359031 26360 None 1 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 3 0 4 3.3 O=C(C1CCCN(S(=O)(=O)c2ccc(Br)s2)C1)N1CCCCCC1 nan
2871937 26361 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 4 0 4 4.7 COc1ccc(C2CC(c3ccccc3)=NN2C(=O)c2cccs2)cc1 nan
CHEMBL1359037 26361 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 4 0 4 4.7 COc1ccc(C2CC(c3ccccc3)=NN2C(=O)c2cccs2)cc1 nan
2885878 26373 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 418 11 1 8 3.9 CCN(CC)c1nc(SCCOC(=O)Nc2ccccc2)nc(N(CC)CC)n1 nan
CHEMBL1359154 26373 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 418 11 1 8 3.9 CCN(CC)c1nc(SCCOC(=O)Nc2ccccc2)nc(N(CC)CC)n1 nan
5461309 26374 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 11 1 3 6.6 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NP(=O)(c1ccccc1)c1ccccc1)c1ccc(C(=O)OC)cc1 nan
CHEMBL1359157 26374 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 11 1 3 6.6 CCC[C@@H]1C[C@@]1(CCC)[C@@H](NP(=O)(c1ccccc1)c1ccccc1)c1ccc(C(=O)OC)cc1 nan
3245373 26382 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 4 1 8 2.8 CCOC(=O)N1CCN(C(=O)c2ccc(Cn3c(=S)[nH]c4cc5c(cc4c3=O)OCO5)cc2)CC1 nan
CHEMBL1359238 26382 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 496 4 1 8 2.8 CCOC(=O)N1CCN(C(=O)c2ccc(Cn3c(=S)[nH]c4cc5c(cc4c3=O)OCO5)cc2)CC1 nan
2194734 26383 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 8 1 4 6.6 CCCCC(=O)N(c1ccc(C(=O)O)cc1)c1nc(-c2ccc(Cl)cc2)c(CC)s1 nan
CHEMBL1359246 26383 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 8 1 4 6.6 CCCCC(=O)N(c1ccc(C(=O)O)cc1)c1nc(-c2ccc(Cl)cc2)c(CC)s1 nan
16746421 26384 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 5 0 2 7.4 COc1ccc(-c2c([C@H]3[C@H]4C=CC[C@@H](C)[C@@H]4C(=O)N3Cc3ccccc3)ccc3ccccc23)cc1 nan
CHEMBL1359252 26384 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 5 0 2 7.4 COc1ccc(-c2c([C@H]3[C@H]4C=CC[C@@H](C)[C@@H]4C(=O)N3Cc3ccccc3)ccc3ccccc23)cc1 nan
1070356 26389 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 3 0 6 4.1 O=C(c1cc2nc(-c3ccco3)cc(C(F)(F)F)n2n1)N1CCN(c2ccc(F)cc2)CC1 nan
CHEMBL1359271 26389 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 3 0 6 4.1 O=C(c1cc2nc(-c3ccco3)cc(C(F)(F)F)n2n1)N1CCN(c2ccc(F)cc2)CC1 nan
5308181 26390 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 5 1 7 4.1 COC(=O)c1cc(NC2c3ccccc3C(=O)N2c2ccc(Cl)cn2)cc(C(=O)OC)c1 nan
CHEMBL1359279 26390 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 451 5 1 7 4.1 COC(=O)c1cc(NC2c3ccccc3C(=O)N2c2ccc(Cl)cn2)cc(C(=O)OC)c1 nan
1898213 26396 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 520 6 1 6 3.8 CCn1cc(C(=O)NCc2cccc(F)c2)c(=O)c2cc(F)c(N3CCN(C(=O)c4ccco4)CC3)cc21 nan
CHEMBL1359319 26396 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 520 6 1 6 3.8 CCn1cc(C(=O)NCc2cccc(F)c2)c(=O)c2cc(F)c(N3CCN(C(=O)c4ccco4)CC3)cc21 nan
2727064 26408 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 6 2 4 4.5 O=C(NC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)Nc1ccccc1 nan
CHEMBL1359400 26408 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 6 2 4 4.5 O=C(NC(=O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)Nc1ccccc1 nan
658547 26428 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 3 0 7 4.3 CC1(C)Cc2c(C#N)c(N3CCN(C(=O)c4ccco4)CC3)nc(-c3ccco3)c2CS1 nan
CHEMBL1359564 26428 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 3 0 7 4.3 CC1(C)Cc2c(C#N)c(N3CCN(C(=O)c4ccco4)CC3)nc(-c3ccco3)c2CS1 nan
2179970 26433 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 4.4 COc1ccccc1N=C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 nan
5645776 26433 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 4.4 COc1ccccc1N=C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 nan
6851028 26433 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 4.4 COc1ccccc1N=C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 nan
CHEMBL1359606 26433 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 400 5 1 4 4.4 COc1ccccc1N=C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccccc1 nan
2973864 26437 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 1 4 3.7 O=C(Nc1ccc2c(c1)oc1ccc(S(=O)(=O)N3CCCC3)cc12)C1CC1 nan
CHEMBL1359630 26437 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 1 4 3.7 O=C(Nc1ccc2c(c1)oc1ccc(S(=O)(=O)N3CCCC3)cc12)C1CC1 nan
648955 26444 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 0 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)n2c(CN3CCOCC3)nc3ccccc32)cc1 nan
CHEMBL1359740 26444 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 4 0 6 3.4 CC(C)(C)c1ccc(S(=O)(=O)n2c(CN3CCOCC3)nc3ccccc32)cc1 nan
1894066 26445 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 4 1 5 4.5 O=C1/C(=C/c2cccs2)N=C(c2cccs2)N1Nc1ccccc1 nan
CHEMBL1359749 26445 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 4 1 5 4.5 O=C1/C(=C/c2cccs2)N=C(c2cccs2)N1Nc1ccccc1 nan
646323 26446 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 7 0 8 2.1 CCCCOC(=O)Cn1c(=O)c2c(nc(Br)n2Cc2ccccc2)n(C)c1=O nan
CHEMBL1359750 26446 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 448 7 0 8 2.1 CCCCOC(=O)Cn1c(=O)c2c(nc(Br)n2Cc2ccccc2)n(C)c1=O nan
16189221 26448 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 6 2 3 4.6 COc1cccc(CC2(CO)CCCN(Cc3[nH]c4ccc(C)cc4c3C)C2)c1 nan
CHEMBL1359762 26448 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 6 2 3 4.6 COc1cccc(CC2(CO)CCCN(Cc3[nH]c4ccc(C)cc4c3C)C2)c1 nan
2869028 26452 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 465 4 1 6 4.1 CNC(=Nc1cc(Cl)ccc1Cl)SC1CC(=O)N(c2ccc(C(=O)OC)cc2)C1=O nan
CHEMBL1359792 26452 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 465 4 1 6 4.1 CNC(=Nc1cc(Cl)ccc1Cl)SC1CC(=O)N(c2ccc(C(=O)OC)cc2)C1=O nan
2843055 26453 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 3 0 4 5.0 Fc1ccc(N2N=C(c3cccs3)CC2c2ccco2)c(F)c1 nan
CHEMBL1359796 26453 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 330 3 0 4 5.0 Fc1ccc(N2N=C(c3cccs3)CC2c2ccco2)c(F)c1 nan
2024889 26457 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 2 6 4.1 Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1CCc1ccc(F)cc1 nan
CHEMBL1359842 26457 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 429 6 2 6 4.1 Nc1c(C(=O)NCc2ccco2)c2nc3ccccc3nc2n1CCc1ccc(F)cc1 nan
4971492 26466 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 2 1 4 4.2 Cc1ccccc1NC(=O)c1cn2c(nc3ccccc32)c(C#N)c1C nan
CHEMBL1359942 26466 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 340 2 1 4 4.2 Cc1ccccc1NC(=O)c1cn2c(nc3ccccc32)c(C#N)c1C nan
1472977 26476 None 12 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 2 0 3 5.3 Brc1cc(Br)c2nc(-c3ccc(N4CCOCC4)cc3)ccc2c1 nan
CHEMBL1360031 26476 None 12 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 2 0 3 5.3 Brc1cc(Br)c2nc(-c3ccc(N4CCOCC4)cc3)ccc2c1 nan
16194012 26498 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 1 5 4.3 Cc1ccnc(NC(=O)c2cc3c(=O)oc4ccc(C)cc4c3s2)c1 nan
CHEMBL1360229 26498 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 2 1 5 4.3 Cc1ccnc(NC(=O)c2cc3c(=O)oc4ccc(C)cc4c3s2)c1 nan
3243807 26503 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 0 5 4.4 COc1ccc(-c2cc(C(=O)N3CC4(C)CC3CC(C)(C)C4)no2)cc1OC nan
CHEMBL1360269 26503 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 4 0 5 4.4 COc1ccc(-c2cc(C(=O)N3CC4(C)CC3CC(C)(C)C4)no2)cc1OC nan
5123484 26512 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 5 1 3 6.4 CC(c1cccs1)N(Cc1ccco1)C(=O)Nc1ccc(Cl)c(Cl)c1 nan
CHEMBL1360300 26512 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 394 5 1 3 6.4 CC(c1cccs1)N(Cc1ccco1)C(=O)Nc1ccc(Cl)c(Cl)c1 nan
3245711 26518 None 1 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 2 1 3 4.9 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCSC1c1ccco1 nan
CHEMBL1360343 26518 None 1 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 342 2 1 3 4.9 O=C(Nc1ccc(Cl)c(Cl)c1)N1CCSC1c1ccco1 nan
991663 26537 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 3 0 3 3.5 Cc1ccc(N(C)C(=O)N2CCN(S(=O)(=O)c3c(C)cc(C)cc3C)CC2)cc1 nan
CHEMBL1360533 26537 None 15 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 3 0 3 3.5 Cc1ccc(N(C)C(=O)N2CCN(S(=O)(=O)c3c(C)cc(C)cc3C)CC2)cc1 nan
2940694 26568 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 5 2 4 2.8 COC(=O)C(Cc1ccc(O)cc1)NC(=O)C12CC3CC(CC(C3)C1)C2 nan
CHEMBL1360822 26568 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 5 2 4 2.8 COC(=O)C(Cc1ccc(O)cc1)NC(=O)C12CC3CC(CC(C3)C1)C2 nan
16189043 26592 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 3 1 5 4.5 CSc1nc(C(=O)N2CCc3c([nH]c4ccccc34)C2c2ccccn2)cs1 nan
CHEMBL1361044 26592 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 3 1 5 4.5 CSc1nc(C(=O)N2CCc3c([nH]c4ccccc34)C2c2ccccn2)cs1 nan
3356001 26594 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 3 0 5 4.3 COc1ccccc1-c1c(C)nn2c(N3CCC(C)CC3)cc(C)nc12 nan
CHEMBL1361075 26594 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 350 3 0 5 4.3 COc1ccccc1-c1c(C)nn2c(N3CCC(C)CC3)cc(C)nc12 nan
2840223 26605 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 4 0 8 4.9 COC(=O)C1=C(C(=O)OC)SC(=C2C(=S)C(C)(C)N(C(=O)CC(C)C)c3ccccc32)S1 nan
CHEMBL1361153 26605 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 491 4 0 8 4.9 COC(=O)C1=C(C(=O)OC)SC(=C2C(=S)C(C)(C)N(C(=O)CC(C)C)c3ccccc32)S1 nan
2449963 26606 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 9 1 7 5.4 CCOC(=O)Cc1csc(SCC(=O)Nc2cc(Cl)ccc2Oc2ccccc2)n1 nan
CHEMBL1361167 26606 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 462 9 1 7 5.4 CCOC(=O)Cc1csc(SCC(=O)Nc2cc(Cl)ccc2Oc2ccccc2)n1 nan
2411471 26616 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 3 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cc3ccncc3)cc2)cc1 nan
CHEMBL1361279 26616 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 380 5 1 3 4.8 CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(Cc3ccncc3)cc2)cc1 nan
2906313 26629 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 7 1 6 4.6 CCCSC1=C(C#N)C(c2cccnc2)C(C(=O)OCC)=C(c2ccccc2)N1 nan
CHEMBL1361427 26629 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 405 7 1 6 4.6 CCCSC1=C(C#N)C(c2cccnc2)C(C(=O)OCC)=C(c2ccccc2)N1 nan
666439 26633 None 11 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 5 0 9 2.9 COc1ccc(N2CC(C)Cn3c2nc2c3c(=O)n(Cc3ccc(F)cc3)c(=O)n2C)c(OC)c1 nan
CHEMBL1361490 26633 None 11 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 5 0 9 2.9 COc1ccc(N2CC(C)Cn3c2nc2c3c(=O)n(Cc3ccc(F)cc3)c(=O)n2C)c(OC)c1 nan
1822015 26636 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 7 3 7 3.4 CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)/C=C/c3ccccc3)cc2)s1 nan
CHEMBL1361498 26636 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 7 3 7 3.4 CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)/C=C/c3ccccc3)cc2)s1 nan
6062931 26642 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 6 1 5 4.3 COc1cc(/C=C(\C#N)C(=O)c2c(C)[nH]c3ccccc23)cc(OC)c1OC nan
CHEMBL1361549 26642 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 6 1 5 4.3 COc1cc(/C=C(\C#N)C(=O)c2c(C)[nH]c3ccccc23)cc(OC)c1OC nan
3542314 26643 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 7 1 5 5.0 CCc1cc(C(c2cccc(OC)c2)N2CCOCC2)c(NC(=O)c2ccccc2)s1 nan
CHEMBL1361551 26643 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 7 1 5 5.0 CCc1cc(C(c2cccc(OC)c2)N2CCOCC2)c(NC(=O)c2ccccc2)s1 nan
3238314 26647 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 8 0 6 3.9 CCN(CCCn1c(SCC#N)nc2ccccc2c1=O)c1ccccc1 nan
CHEMBL1361588 26647 None 2 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 8 0 6 3.9 CCN(CCCn1c(SCC#N)nc2ccccc2c1=O)c1ccccc1 nan
2960075 26657 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 0 5 4.6 Cc1ccccc1OC1C(=O)N(Cc2ccc3c(c2)OCO3)C1c1sccc1C nan
CHEMBL1361675 26657 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 0 5 4.6 Cc1ccccc1OC1C(=O)N(Cc2ccc3c(c2)OCO3)C1c1sccc1C nan
16187879 26675 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 481 7 1 5 5.8 Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)Nc4ccc(CN5CCCC5)cc4)c(C)nc32)cc1 nan
CHEMBL1361820 26675 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 481 7 1 5 5.8 Cc1ccc(-n2nc(C)c3c(C)c(CCC(=O)Nc4ccc(CN5CCCC5)cc4)c(C)nc32)cc1 nan
651881 26682 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 8 3 8 1.2 COc1ccc(CCNC(=O)CSc2cc(O)nc(N)n2)cc1OC nan
CHEMBL1361871 26682 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 8 3 8 1.2 COc1ccc(CCNC(=O)CSc2cc(O)nc(N)n2)cc1OC nan
1248897 26693 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 8 1 7 5.1 O=C(CSc1nnc(Cc2cccs2)n1Cc1ccco1)Nc1ccc(Br)cc1 nan
CHEMBL1361955 26693 None 6 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 488 8 1 7 5.1 O=C(CSc1nnc(Cc2cccs2)n1Cc1ccco1)Nc1ccc(Br)cc1 nan
2055748 26710 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 279 1 0 6 2.7 CSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)S1 nan
CHEMBL1362111 26710 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 279 1 0 6 2.7 CSC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)S1 nan
1441832 26718 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 7 4.0 Clc1cccc(-c2cc3nc4c(c(N5CCN(c6cnccn6)CC5)n3n2)CCCC4)c1 nan
CHEMBL1362146 26718 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 7 4.0 Clc1cccc(-c2cc3nc4c(c(N5CCN(c6cnccn6)CC5)n3n2)CCCC4)c1 nan
1224535 26723 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 4 0 6 4.1 COC(=O)c1ccc(CSc2nc(C(F)(F)F)c3c(c2C#N)CCC3)o1 nan
CHEMBL1362206 26723 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 4 0 6 4.1 COC(=O)c1ccc(CSc2nc(C(F)(F)F)c3c(c2C#N)CCC3)o1 nan
1303230 26761 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 6 1 5 3.6 COC(=O)c1ccccc1NC(=O)c1ccccc1N(C)S(=O)(=O)c1ccccc1 nan
CHEMBL1362529 26761 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 6 1 5 3.6 COC(=O)c1ccccc1NC(=O)c1ccccc1N(C)S(=O)(=O)c1ccccc1 nan
2550784 26777 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 6 0 5 3.3 O=C(OCCCCN1C(=O)c2ccccc2C1=O)c1ccc(Br)o1 nan
CHEMBL1362615 26777 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 391 6 0 5 3.3 O=C(OCCCCN1C(=O)c2ccccc2C1=O)c1ccc(Br)o1 nan
3500086 26791 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 4 0 8 4.1 CCn1nc([N+](=O)[O-])c(C(C#N)c2nc3cc(C(F)(F)F)ccc3s2)c(Cl)c1=O nan
CHEMBL1362734 26791 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 443 4 0 8 4.1 CCn1nc([N+](=O)[O-])c(C(C#N)c2nc3cc(C(F)(F)F)ccc3s2)c(Cl)c1=O nan
993364 26795 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 2 0 5 3.5 CCOC(=O)N1CCN(c2nc(C(F)(F)F)nc3c(C)cc(C)cc23)CC1 nan
CHEMBL1362793 26795 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 2 0 5 3.5 CCOC(=O)N1CCN(c2nc(C(F)(F)F)nc3c(C)cc(C)cc23)CC1 nan
6082354 26796 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 3 5.5 Clc1ccccc1Cn1c(/C=C/c2ccco2)nc2ccccc21 nan
CHEMBL1362799 26796 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 334 4 0 3 5.5 Clc1ccccc1Cn1c(/C=C/c2ccco2)nc2ccccc21 nan
2205484 26805 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 7 1 4 4.4 CS(=O)(=O)N(CC(=O)Nc1ccccc1Sc1ccccc1)c1ccc(F)cc1 nan
CHEMBL1362859 26805 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 430 7 1 4 4.4 CS(=O)(=O)N(CC(=O)Nc1ccccc1Sc1ccccc1)c1ccc(F)cc1 nan
2816169 26826 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 4 0 8 2.8 CCOC(=O)c1nnn2c1nc(N1CCN(c3ccccc3)CC1)c1ccccc12 nan
CHEMBL1363069 26826 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 4 0 8 2.8 CCOC(=O)c1nnn2c1nc(N1CCN(c3ccccc3)CC1)c1ccccc12 nan
16745533 26838 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 911 7 9 16 1.5 CC1OC(OC2C(OC3C(O[C@H]4CC[C@]5(C)C6C=C[C@]78OC[C@@]9(CC[C@@H](C)[C@H](C)C97)[C@H](O)C[C@@]8(C)[C@]6(C)CC[C@H]5C4(C)C)OC(C)C(O)C3O)OC(CO)C(O)C2O)C(O)C(O)C1O nan
CHEMBL1363154 26838 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 911 7 9 16 1.5 CC1OC(OC2C(OC3C(O[C@H]4CC[C@]5(C)C6C=C[C@]78OC[C@@]9(CC[C@@H](C)[C@H](C)C97)[C@H](O)C[C@@]8(C)[C@]6(C)CC[C@H]5C4(C)C)OC(C)C(O)C3O)OC(CO)C(O)C2O)C(O)C(O)C1O nan
135513627 26875 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 271 6 2 4 4.0 CCCCCc1c(C)nc(Nc2ccccc2)nc1O nan
CHEMBL1363514 26875 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 271 6 2 4 4.0 CCCCCc1c(C)nc(Nc2ccccc2)nc1O nan
3193431 26879 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 497 7 0 8 4.3 COc1ccc(Cn2nnnc2C(c2ccc3ncccc3c2)N2CCN(C3CCCCC3)CC2)cc1 nan
CHEMBL1363552 26879 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 497 7 0 8 4.3 COc1ccc(Cn2nnnc2C(c2ccc3ncccc3c2)N2CCN(C3CCCCC3)CC2)cc1 nan
889907 26907 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 5 1 3 4.3 Cc1cc(C)cc(OCC(=O)Nc2ccccc2N2CCCCC2)c1 nan
CHEMBL1363833 26907 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 5 1 3 4.3 Cc1cc(C)cc(OCC(=O)Nc2ccccc2N2CCCCC2)c1 nan
2891928 26916 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 5 2 8 1.5 COC(=O)c1c(NC(=O)CC2SCC(C(=O)OC)NC2=O)sc2c1CCCC2 nan
CHEMBL1363895 26916 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 426 5 2 8 1.5 COC(=O)c1c(NC(=O)CC2SCC(C(=O)OC)NC2=O)sc2c1CCCC2 nan
2568758 26917 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 1 5 4.2 Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2c(C)noc2C)c1 nan
CHEMBL1363905 26917 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 1 5 4.2 Cc1cccc(C(=O)Nc2ccccc2C(=O)OCc2c(C)noc2C)c1 nan
1043839 26925 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 1 0 5 4.6 Cc1cccc(-n2c(=O)c3c(n4cnnc24)-c2ccccc2CC32CCCCC2)c1 nan
CHEMBL1363953 26925 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 1 0 5 4.6 Cc1cccc(-n2c(=O)c3c(n4cnnc24)-c2ccccc2CC32CCCCC2)c1 nan
248711 26935 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 0 5 4.8 COc1cnn(-c2ccccc2)c(=O)c1SCc1ccc(Cl)c(Cl)c1 nan
CHEMBL1364102 26935 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 5 0 5 4.8 COc1cnn(-c2ccccc2)c(=O)c1SCc1ccc(Cl)c(Cl)c1 nan
6511277 26938 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 4 0 6 4.1 O=C1S/C(=C\c2ccc(N3CCOCC3)o2)C(=O)N1Cc1c(F)cccc1Cl nan
CHEMBL1364114 26938 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 422 4 0 6 4.1 O=C1S/C(=C\c2ccc(N3CCOCC3)o2)C(=O)N1Cc1c(F)cccc1Cl nan
3737946 26959 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 4 0 4 4.0 CC12CCC(C(=O)N3CCN(C(c4ccccc4)c4ccccc4)CC3)(OC1=O)C2(C)C nan
CHEMBL1364345 26959 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 4 0 4 4.0 CC12CCC(C(=O)N3CCN(C(c4ccccc4)c4ccccc4)CC3)(OC1=O)C2(C)C nan
16746352 26970 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 4 0 3 4.5 C[C@@H]1CC=C[C@H]2[C@H]1C(=O)N(Cc1ccccc1)[C@H]2c1cccc([N+](=O)[O-])c1 nan
CHEMBL1364390 26970 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 362 4 0 3 4.5 C[C@@H]1CC=C[C@H]2[C@H]1C(=O)N(Cc1ccccc1)[C@H]2c1cccc([N+](=O)[O-])c1 nan
16188637 26972 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 5 5.1 COc1cccc(C2c3[nH]c4ccccc4c3CCN2Cc2cnc(C)s2)c1OC nan
CHEMBL1364399 26972 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 5 1 5 5.1 COc1cccc(C2c3[nH]c4ccccc4c3CCN2Cc2cnc(C)s2)c1OC nan
3244213 26978 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 9 1 3 3.0 CC(C)CN(CC(C)C)S(=O)(=O)N1CCC(C(=O)NCc2ccc(F)cc2)CC1 nan
CHEMBL1364466 26978 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 9 1 3 3.0 CC(C)CN(CC(C)C)S(=O)(=O)N1CCC(C(=O)NCc2ccc(F)cc2)CC1 nan
1960168 26981 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 0 5 4.4 Cc1ccc(-c2nc3c(c(=O)c4ccccc4n3C)c(=O)n2-c2ccc(F)cc2)cc1 nan
CHEMBL1364491 26981 None 6 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 2 0 5 4.4 Cc1ccc(-c2nc3c(c(=O)c4ccccc4n3C)c(=O)n2-c2ccc(F)cc2)cc1 nan
2475651 26982 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 1 6 3.5 CC(C)n1nc(C(=O)OCC(=O)c2c[nH]c3ccccc23)c2ccccc2c1=O nan
CHEMBL1364493 26982 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 1 6 3.5 CC(C)n1nc(C(=O)OCC(=O)c2c[nH]c3ccccc23)c2ccccc2c1=O nan
3242814 26987 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 5 1 5 3.8 CC(C)CCNC(=O)c1cnn2c(C(F)(F)F)cc(-c3ccco3)nc12 nan
CHEMBL1364521 26987 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 366 5 1 5 3.8 CC(C)CCNC(=O)c1cnn2c(C(F)(F)F)cc(-c3ccco3)nc12 nan
662933 26998 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 8 0 8 1.9 CCCCCn1c(CN2CCN(Cc3ccccc3)CC2)nc2c1c(=O)n(C)c(=O)n2C nan
CHEMBL1364609 26998 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 8 0 8 1.9 CCCCCn1c(CN2CCN(Cc3ccccc3)CC2)nc2c1c(=O)n(C)c(=O)n2C nan
2938128 27001 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 8 0 3 4.9 COc1ccccc1C(CCN(Cc1ccccc1)C(C)=O)c1ccco1 nan
CHEMBL1364635 27001 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 8 0 3 4.9 COc1ccccc1C(CCN(Cc1ccccc1)C(C)=O)c1ccco1 nan
3244178 27008 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 6 1 5 2.7 COc1ccc(C2=NOC(C(=O)NCc3ccc(F)cc3)C2)cc1OC nan
CHEMBL1364681 27008 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 6 1 5 2.7 COc1ccc(C2=NOC(C(=O)NCc3ccc(F)cc3)C2)cc1OC nan
646028 27016 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 465 6 2 7 3.1 O=C(NC1CC2CCC(C1)N2Cc1nnnn1Cc1ccco1)NC12CC3CC(CC(C3)C1)C2 nan
CHEMBL1364757 27016 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 465 6 2 7 3.1 O=C(NC1CC2CCC(C1)N2Cc1nnnn1Cc1ccco1)NC12CC3CC(CC(C3)C1)C2 nan
16197019 27018 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 2 4 5.1 CCO[C@@H]1OC(C(=O)Nc2ccccc2)=C[C@H](c2ccc(C(F)(F)F)cc2)[C@H]1CCCO nan
CHEMBL1364779 27018 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 2 4 5.1 CCO[C@@H]1OC(C(=O)Nc2ccccc2)=C[C@H](c2ccc(C(F)(F)F)cc2)[C@H]1CCCO nan
4195993 27020 None 1 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 2 1 6 4.1 COc1ccc(C2C(C#N)=C(N)Oc3c2sc2nc(C)cc(C)c32)cc1 nan
CHEMBL1364787 27020 None 1 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 2 1 6 4.1 COc1ccc(C2C(C#N)=C(N)Oc3c2sc2nc(C)cc(C)c32)cc1 nan
3417593 27034 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 8 0 6 5.0 COc1cc(C(C[N+](=O)[O-])c2c(-c3ccccc3)cc3ccccn23)cc(OC)c1OC nan
CHEMBL1364924 27034 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 8 0 6 5.0 COc1cc(C(C[N+](=O)[O-])c2c(-c3ccccc3)cc3ccccn23)cc(OC)c1OC nan
2951140 27038 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 7 1 3 4.9 CCC1(C)CC(CCNS(=O)(=O)c2ccc(C)cc2)(c2ccc(C)cc2)CCO1 nan
CHEMBL1364963 27038 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 7 1 3 4.9 CCC1(C)CC(CCNS(=O)(=O)c2ccc(C)cc2)(c2ccc(C)cc2)CCO1 nan
78545 27043 None 15 Human Functional pPotency = 5 5.0 -45 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
CHEMBL1364999 27043 None 15 Human Functional pPotency = 5 5.0 -45 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
5308218 27048 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 2.7 O=C(c1ccc(CNc2c(N3CCOCC3)c(=O)c2=O)cc1)N1CC=C(c2ccccc2)CC1 nan
CHEMBL1365043 27048 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 6 1 6 2.7 O=C(c1ccc(CNc2c(N3CCOCC3)c(=O)c2=O)cc1)N1CC=C(c2ccccc2)CC1 nan
1432187 27050 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 0 5 4.1 CC(C)Cn1c(SCC(=O)N2CCCc3ccccc32)nc2ccccc2c1=O nan
CHEMBL1365060 27050 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 5 0 5 4.1 CC(C)Cn1c(SCC(=O)N2CCCc3ccccc32)nc2ccccc2c1=O nan
3430314 27069 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 1 1 3 6.1 CC1(C)CC2=NC3=C(C(=O)c4ccccc43)C(c3ccc(Cl)cc3)C2=C(O)C1 nan
CHEMBL1365226 27069 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 1 1 3 6.1 CC1(C)CC2=NC3=C(C(=O)c4ccccc43)C(c3ccc(Cl)cc3)C2=C(O)C1 nan
653061 27091 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 3 0 7 1.0 C=CCn1c(N2CCCCCC2)nc2c1c(=O)n(C)c(=O)n2C nan
CHEMBL1365333 27091 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 3 0 7 1.0 C=CCn1c(N2CCCCCC2)nc2c1c(=O)n(C)c(=O)n2C nan
1283398 27116 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 4 3 5 5.6 CC(=O)Nc1ccc(NC(=O)c2sc3nc4c(c(-c5ccc(C)cc5)c3c2N)CCC4)cc1 nan
CHEMBL1365578 27116 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 4 3 5 5.6 CC(=O)Nc1ccc(NC(=O)c2sc3nc4c(c(-c5ccc(C)cc5)c3c2N)CCC4)cc1 nan
2084325 27124 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 5 1 5 3.3 CC1(C)Cc2cccc(OCC(=O)Nc3ccccc3N3CCOCC3)c2O1 nan
CHEMBL1365624 27124 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 5 1 5 3.3 CC1(C)Cc2cccc(OCC(=O)Nc3ccccc3N3CCOCC3)c2O1 nan
11948872 27128 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 3 1 3 6.0 O=C(c1ccccc1Cl)N1N=C(c2ccc(Br)cc2)CC1c1nc2ccccc2[nH]1 nan
CHEMBL1365654 27128 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 3 1 3 6.0 O=C(c1ccccc1Cl)N1N=C(c2ccc(Br)cc2)CC1c1nc2ccccc2[nH]1 nan
16196985 27144 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 9 3 5 4.1 O=C(NCc1nc2ccccc2[nH]1)C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCCCCO)O1 nan
CHEMBL1365838 27144 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 9 3 5 4.1 O=C(NCc1nc2ccccc2[nH]1)C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCCCCO)O1 nan
4451944 27177 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 0 6 5.4 CCOP(=O)(OCC)c1nc(-c2cccc3ccccc23)oc1N1CCCCC1 nan
CHEMBL1366118 27177 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 414 7 0 6 5.4 CCOP(=O)(OCC)c1nc(-c2cccc3ccccc23)oc1N1CCCCC1 nan
1086226 27193 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 280 3 0 3 4.0 Cc1ccc(CSc2nc3c(cc2C#N)CCC3)cc1 nan
CHEMBL1366259 27193 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 280 3 0 3 4.0 Cc1ccc(CSc2nc3c(cc2C#N)CCC3)cc1 nan
4199625 27209 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 4 1 4 4.0 CCC(CC)C(=O)Nc1cc(C)c2c(=O)oc3ccccc3c2n1 nan
CHEMBL1366381 27209 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 324 4 1 4 4.0 CCC(CC)C(=O)Nc1cc(C)c2c(=O)oc3ccccc3c2n1 nan
1489331 27210 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 6 0 5 4.5 COc1ccc(N(Cc2c(C(F)(F)F)nn(C)c2Cl)S(=O)(=O)c2ccccc2)cc1 nan
CHEMBL1366390 27210 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 459 6 0 5 4.5 COc1ccc(N(Cc2c(C(F)(F)F)nn(C)c2Cl)S(=O)(=O)c2ccccc2)cc1 nan
6021157 27219 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 3 0 4 5.9 Cc1ncsc1C(=O)N1N=C2/C(=C/c3ccccc3)CCCC2C1c1ccccc1 nan
CHEMBL1366446 27219 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 413 3 0 4 5.9 Cc1ncsc1C(=O)N1N=C2/C(=C/c3ccccc3)CCCC2C1c1ccccc1 nan
651025 27221 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 5 1 7 2.8 CCCN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cc(OC)ccc3OC)C2C1 nan
CHEMBL1366453 27221 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 5 1 7 2.8 CCCN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cc(OC)ccc3OC)C2C1 nan
3238206 27228 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 7 2.6 CCCCCn1c(CN2CCN(c3cccc(Cl)c3)CC2)nc2c1c(=O)[nH]c(=O)n2C nan
CHEMBL1366498 27228 None 7 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 444 7 1 7 2.6 CCCCCn1c(CN2CCN(c3cccc(Cl)c3)CC2)nc2c1c(=O)[nH]c(=O)n2C nan
135417990 27251 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 5 2 5 4.6 CCc1ccc(NCc2cc3c(C)nn(-c4ccccc4)c3nc2O)cc1 nan
CHEMBL1366793 27251 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 358 5 2 5 4.6 CCc1ccc(NCc2cc3c(C)nn(-c4ccccc4)c3nc2O)cc1 nan
2964983 27260 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 506 12 1 7 4.9 C=CCn1c(CCNC(=O)c2ccc(Cl)c(Cl)c2)nnc1SCCOc1ccc(OC)cc1 nan
CHEMBL1366836 27260 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 506 12 1 7 4.9 C=CCn1c(CCNC(=O)c2ccc(Cl)c(Cl)c2)nnc1SCCOc1ccc(OC)cc1 nan
16197151 27261 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 9 2 4 4.8 CCO[C@@H]1OC(C(=O)NCc2ccccc2)=C[C@H](c2ccc(C(F)(F)F)cc2)[C@H]1CCCO nan
CHEMBL1366851 27261 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 9 2 4 4.8 CCO[C@@H]1OC(C(=O)NCc2ccccc2)=C[C@H](c2ccc(C(F)(F)F)cc2)[C@H]1CCCO nan
7299199 27263 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 4 1 7 4.6 CSc1ccc(-c2nc3cnccn3c2Nc2ccc3c(c2)OCO3)cc1 nan
CHEMBL1366860 27263 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 376 4 1 7 4.6 CSc1ccc(-c2nc3cnccn3c2Nc2ccc3c(c2)OCO3)cc1 nan
666292 27268 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 8 2 8 3.6 Cc1ccc(-n2c(Cc3cccs3)nnc2SCC(=O)Nc2ccc(S(N)(=O)=O)cc2)cc1 nan
CHEMBL1366920 27268 None 5 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 8 2 8 3.6 Cc1ccc(-n2c(Cc3cccs3)nnc2SCC(=O)Nc2ccc(S(N)(=O)=O)cc2)cc1 nan
3191142 27276 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 7 1 4 5.5 Cc1cc(C)cc(N(C(=O)Cc2cccs2)C(C(=O)NC2CCCCC2)c2ccccn2)c1 nan
CHEMBL1366995 27276 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 7 1 4 5.5 Cc1cc(C)cc(N(C(=O)Cc2cccs2)C(C(=O)NC2CCCCC2)c2ccccn2)c1 nan
2999882 27279 None 20 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 7 1 5 2.9 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1 nan
CHEMBL1367025 27279 None 20 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 341 7 1 5 2.9 COCCCN1C(=O)C(O)=C(C(=O)c2ccco2)C1c1ccccc1 nan
5390009 27292 None 8 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 4 0 7 3.3 Cn1c(=O)n(C/C=C/c2ccccc2)c(=O)c2c1nc1n2CCCN1c1ccc(F)cc1 nan
CHEMBL1367120 27292 None 8 Human Functional pPotency = 5 5.0 -15 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 4 0 7 3.3 Cn1c(=O)n(C/C=C/c2ccccc2)c(=O)c2c1nc1n2CCCN1c1ccc(F)cc1 nan
16745879 27294 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 5 1 2 3.4 O=C1NC[C@@H](Cc2cccc3ccccc23)N(CC2(c3ccccc3)CC2)C1=O nan
CHEMBL1367134 27294 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 5 1 2 3.4 O=C1NC[C@@H](Cc2cccc3ccccc23)N(CC2(c3ccccc3)CC2)C1=O nan
9551693 27295 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 537 5 0 8 4.9 COc1ccc([C@H]2[C@H](C(=O)C(C)(C)C)N3N=Cc4ccccc4C3[C@]23N=C(c2ccccc2)OC3=O)cc1OC nan
CHEMBL1367147 27295 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 537 5 0 8 4.9 COc1ccc([C@H]2[C@H](C(=O)C(C)(C)C)N3N=Cc4ccccc4C3[C@]23N=C(c2ccccc2)OC3=O)cc1OC nan
666926 27299 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 7 0 9 2.7 COc1ccc(N2CCn3c2nc2c3c(=O)n(CCCc3ccccc3)c(=O)n2C)c(OC)c1 nan
CHEMBL1367217 27299 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 7 0 9 2.7 COc1ccc(N2CCn3c2nc2c3c(=O)n(CCCc3ccccc3)c(=O)n2C)c(OC)c1 nan
3247078 27302 None 0 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 621 8 0 7 5.2 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]2c3cc(C(=O)N4CCCC4)n(Cc4ccc(C)o4)c3C[C@H]2CN1C(=O)c1ccccc1 nan
CHEMBL1367222 27302 None 0 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 621 8 0 7 5.2 COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]2c3cc(C(=O)N4CCCC4)n(Cc4ccc(C)o4)c3C[C@H]2CN1C(=O)c1ccccc1 nan
3323366 27303 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 2 1 7 3.0 COC(=O)c1sc2cc(=O)n(-c3cccc(C(F)(F)F)c3)nc2c1O nan
CHEMBL1367228 27303 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 2 1 7 3.0 COC(=O)c1sc2cc(=O)n(-c3cccc(C(F)(F)F)c3)nc2c1O nan
775998 27312 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 268 2 2 2 3.9 Cc1ccc(-c2cc(-c3cccc(F)c3)[nH]n2)c(O)c1 nan
CHEMBL1367313 27312 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 268 2 2 2 3.9 Cc1ccc(-c2cc(-c3cccc(F)c3)[nH]n2)c(O)c1 nan
2221997 27313 None 9 Human Functional pPotency = 5 5.0 -7 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
CHEMBL1367316 27313 None 9 Human Functional pPotency = 5 5.0 -7 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
2997852 27319 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 7 0 7 3.0 CCCCn1c(=O)n(Cc2cccc(F)c2)c(=O)c2c1ncn2Cc1ccco1 nan
CHEMBL1367356 27319 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 7 0 7 3.0 CCCCn1c(=O)n(Cc2cccc(F)c2)c(=O)c2c1ncn2Cc1ccco1 nan
709114 27331 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 5 1 5 3.6 CCOC(=O)c1cnc2ccccc2c1NCc1ccco1 nan
CHEMBL1367438 27331 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 296 5 1 5 3.6 CCOC(=O)c1cnc2ccccc2c1NCc1ccco1 nan
2507705 27332 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 7 1 9 4.1 CCOC(=O)c1c(-c2ccc(C)o2)csc1NC(=O)CSc1nncs1 nan
CHEMBL1367444 27332 None 2 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 409 7 1 9 4.1 CCOC(=O)c1c(-c2ccc(C)o2)csc1NC(=O)CSc1nncs1 nan
650612 27342 None 3 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 7 1 3 4.5 CCCCCC(=O)Nc1ccccc1N1CCN(c2ccccc2)CC1 nan
CHEMBL1367539 27342 None 3 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 7 1 3 4.5 CCCCCC(=O)Nc1ccccc1N1CCN(c2ccccc2)CC1 nan
1004689 27344 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 2 4 3.8 COc1ccc(-c2[nH]ncc2/C=C(/C#N)C(=O)NC2CCCCCC2)cc1 nan
CHEMBL1367572 27344 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 5 2 4 3.8 COc1ccc(-c2[nH]ncc2/C=C(/C#N)C(=O)NC2CCCCCC2)cc1 nan
11835310 27351 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 11 1 4 5.0 CCCN(CCC)CC(O)Cn1cc(/C=C/C(=O)c2ccccc2)c2ccccc21 nan
CHEMBL1367626 27351 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 11 1 4 5.0 CCCN(CCC)CC(O)Cn1cc(/C=C/C(=O)c2ccccc2)c2ccccc21 nan
16746410 27353 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 567 14 0 8 6.6 CCCCCc1cc(=O)oc2c(C(CCN3CCCCC3)c3cc(OC)c(OC)c(OC)c3)c(OC)cc(OC)c12 nan
CHEMBL1367633 27353 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 567 14 0 8 6.6 CCCCCc1cc(=O)oc2c(C(CCN3CCCCC3)c3cc(OC)c(OC)c(OC)c3)c(OC)cc(OC)c12 nan
1548125 27354 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 260 3 0 5 2.5 COC(=O)c1nc(-c2ccc(C)cc2)oc1N(C)C nan
CHEMBL1367634 27354 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 260 3 0 5 2.5 COC(=O)c1nc(-c2ccc(C)cc2)oc1N(C)C nan
2353861 27361 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 3 0 4 6.3 Cc1ccsc1C(=O)N(c1nc2ccccc2s1)c1c(C)cccc1C nan
CHEMBL1367662 27361 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 378 3 0 4 6.3 Cc1ccsc1C(=O)N(c1nc2ccccc2s1)c1c(C)cccc1C nan
654196 27364 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 7 0 6 4.9 CCN(Cc1ccccc1)C(c1cccs1)c1nnnn1C1CCCCC1 nan
CHEMBL1367702 27364 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 7 0 6 4.9 CCN(Cc1ccccc1)C(c1cccs1)c1nnnn1C1CCCCC1 nan
11958820 27374 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 506 7 1 9 6.0 COc1cccc(N(C(=O)c2ccco2)c2nc(-c3sc(NC(=O)c4ccco4)nc3C)cs2)c1 nan
CHEMBL1367776 27374 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 506 7 1 9 6.0 COc1cccc(N(C(=O)c2ccco2)c2nc(-c3sc(NC(=O)c4ccco4)nc3C)cs2)c1 nan
346838 27382 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 252 2 1 4 2.9 COc1ccc(C(C#N)=C2C=CC(=NO)C=C2)cc1 nan
CHEMBL1367860 27382 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 252 2 1 4 2.9 COc1ccc(C(C#N)=C2C=CC(=NO)C=C2)cc1 nan
2745451 27393 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 5 0 8 4.0 CCOC(=O)c1nc(C)sc1-c1ccnn1S(=O)(=O)c1ccc(Cl)cc1Cl nan
CHEMBL1367919 27393 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 5 0 8 4.0 CCOC(=O)c1nc(C)sc1-c1ccnn1S(=O)(=O)c1ccc(Cl)cc1Cl nan
5017051 27395 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 6 3.7 Cc1ccc(-c2nc(N)sc2CC(=O)OCC(=O)NC2CCCC(C)C2C)cc1 nan
CHEMBL1367926 27395 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 6 2 6 3.7 Cc1ccc(-c2nc(N)sc2CC(=O)OCC(=O)NC2CCCC(C)C2C)cc1 nan
16745409 27462 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 7 2 5 4.6 O=C(NC1CC1)C1=C[C@H](c2csc3ccccc23)C[C@H](OCc2ccc(CO)cc2)O1 nan
CHEMBL1368424 27462 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 7 2 5 4.6 O=C(NC1CC1)C1=C[C@H](c2csc3ccccc23)C[C@H](OCc2ccc(CO)cc2)O1 nan
3228266 27467 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 0 8 3.4 O=C(c1ccco1)N1CCN(c2nc(C3CC3)nc3c2nnn3Cc2ccccc2Cl)CC1 nan
CHEMBL1368484 27467 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 5 0 8 3.4 O=C(c1ccco1)N1CCN(c2nc(C3CC3)nc3c2nnn3Cc2ccccc2Cl)CC1 nan
2237347 27478 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 8 2 4 4.9 Cc1ccccc1NS(=O)(=O)c1cc(C(=O)NCCSC2CCCCC2)ccc1C nan
CHEMBL1368553 27478 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 446 8 2 4 4.9 Cc1ccccc1NS(=O)(=O)c1cc(C(=O)NCCSC2CCCCC2)ccc1C nan
3242495 27484 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 6 1 8 3.0 Nc1nonc1-c1noc(CCCOc2ccc(Cl)cc2Cl)n1 nan
CHEMBL1368597 27484 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 6 1 8 3.0 Nc1nonc1-c1noc(CCCOc2ccc(Cl)cc2Cl)n1 nan
3913718 27486 None 10 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 1 0 5 3.9 Clc1ncnc2scc(C3COc4ccccc4O3)c12 nan
CHEMBL1368609 27486 None 10 Human Functional pPotency = 5 5.0 -2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 304 1 0 5 3.9 Clc1ncnc2scc(C3COc4ccccc4O3)c12 nan
2214022 27488 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 4.5 CC(C)N(Cc1nc(-c2ccc(Cl)cc2)no1)C(=O)c1cccs1 nan
CHEMBL1368621 27488 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 5 0 5 4.5 CC(C)N(Cc1nc(-c2ccc(Cl)cc2)no1)C(=O)c1cccs1 nan
5068513 27501 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 0 3 4.5 COc1ccccc1CN1C(=O)CN(C2CCCCCC2)C(=O)C1c1ccc(F)cc1 nan
CHEMBL1368760 27501 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 424 5 0 3 4.5 COc1ccccc1CN1C(=O)CN(C2CCCCCC2)C(=O)C1c1ccc(F)cc1 nan
63204 27527 None 36 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 256 1 1 3 3.7 Oc1nc(-c2ccccc2)c2cc(Cl)ccc2n1 nan
CHEMBL1368964 27527 None 36 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 256 1 1 3 3.7 Oc1nc(-c2ccccc2)c2cc(Cl)ccc2n1 nan
2927808 27536 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 3 0 2 4.1 Cc1cccc(C)c1OCC(=O)N1CC2(C)CC1CC(C)(C)C2 nan
CHEMBL1369031 27536 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 315 3 0 2 4.1 Cc1cccc(C)c1OCC(=O)N1CC2(C)CC1CC(C)(C)C2 nan
645310 27538 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 325 3 1 4 3.7 CC(C)Oc1ccccc1C1CC(=O)Nc2cc3c(cc21)OCO3 nan
CHEMBL1369033 27538 None 6 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 325 3 1 4 3.7 CC(C)Oc1ccccc1C1CC(=O)Nc2cc3c(cc21)OCO3 nan
2336835 27564 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 6 2 5 5.0 O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc1NS(=O)(=O)c1ccc(F)cc1 nan
CHEMBL1369200 27564 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 6 2 5 5.0 O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc1NS(=O)(=O)c1ccc(F)cc1 nan
2530144 27571 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 6 1 9 4.0 Cc1ccc(C)c(-n2nnnc2SCC(=O)Nc2cccc(-c3nnc4n3CCCCC4)c2)c1 nan
CHEMBL1369249 27571 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 6 1 9 4.0 Cc1ccc(C)c(-n2nnnc2SCC(=O)Nc2cccc(-c3nnc4n3CCCCC4)c2)c1 nan
16682602 27576 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 5 1 3 5.2 NC1=NC[C@H](CC2CCCCC2)N1CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL1369287 27576 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 421 5 1 3 5.2 NC1=NC[C@H](CC2CCCCC2)N1CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
3244216 27582 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 6 1 4 4.5 CC(C)c1ccc(NC(=O)C(c2ccccc2)N2CCN(C(=O)c3ccco3)CC2)cc1 nan
CHEMBL1369327 27582 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 6 1 4 4.5 CC(C)c1ccc(NC(=O)C(c2ccccc2)N2CCN(C(=O)c3ccco3)CC2)cc1 nan
6099892 27584 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 544 8 0 3 6.1 O=C(c1ccc(Cl)c(Cl)c1)N1CCC(=O)N(C(COCc2ccc(Cl)cc2)Cc2ccccc2)CC1 nan
CHEMBL1369332 27584 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 544 8 0 3 6.1 O=C(c1ccc(Cl)c(Cl)c1)N1CCC(=O)N(C(COCc2ccc(Cl)cc2)Cc2ccccc2)CC1 nan
2268436 27585 None 10 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 7 2 4 4.6 CCCOc1cccc(C(=O)Nc2cccc(NC(=O)c3ccco3)c2)c1 nan
CHEMBL1369340 27585 None 10 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 364 7 2 4 4.6 CCCOc1cccc(C(=O)Nc2cccc(NC(=O)c3ccco3)c2)c1 nan
2265956 27594 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 4 1 5 4.1 O=C1NC(=O)N(c2ccccc2)C(=O)/C1=C/c1ccc(Sc2ccccc2)o1 nan
CHEMBL1369433 27594 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 390 4 1 5 4.1 O=C1NC(=O)N(c2ccccc2)C(=O)/C1=C/c1ccc(Sc2ccccc2)o1 nan
1527239 27598 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 5.7 COc1cc2c(cc1OC)C(c1ccc(-c3ccc(Cl)c(Cl)c3)o1)=NCC2 nan
CHEMBL1369478 27598 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 4 0 4 5.7 COc1cc2c(cc1OC)C(c1ccc(-c3ccc(Cl)c(Cl)c3)o1)=NCC2 nan
2065001 27630 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 8 2 6 2.6 CCCCCCN1C(=O)/C(=C/Nc2ccccc2N2CCOCC2)C(=O)NC1=S nan
CHEMBL1369743 27630 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 416 8 2 6 2.6 CCCCCCN1C(=O)/C(=C/Nc2ccccc2N2CCOCC2)C(=O)NC1=S nan
5738821 27634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 2 2 2 5.7 CC1CC2=C(N=C(S)NC2c2ccccc2F)/C(=C/c2ccccc2F)C1 nan
CHEMBL1369767 27634 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 382 2 2 2 5.7 CC1CC2=C(N=C(S)NC2c2ccccc2F)/C(=C/c2ccccc2F)C1 nan
9551055 27650 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 5 1 6 4.6 COc1ccc2c(c1)CCc1c(C(=O)Nc3c(C)nn(Cc4ccccc4)c3C)noc1-2 nan
CHEMBL1369837 27650 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 428 5 1 6 4.6 COc1ccc2c(c1)CCc1c(C(=O)Nc3c(C)nn(Cc4ccccc4)c3C)noc1-2 nan
1128149 27681 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 4 0 3 4.8 CCCC(=O)O[C@@H]1C[C@@H](C)N(C(=O)c2ccccc2)c2ccc(C)cc21 nan
CHEMBL1370005 27681 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 351 4 0 3 4.8 CCCC(=O)O[C@@H]1C[C@@H](C)N(C(=O)c2ccccc2)c2ccc(C)cc21 nan
3243754 27686 None 3 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 5 4.4 Cc1ccc(CNC(=O)c2cn(C3CCCC3)c(=O)c3c2c2ccccc2n3C)o1 nan
CHEMBL1370036 27686 None 3 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 1 5 4.4 Cc1ccc(CNC(=O)c2cn(C3CCCC3)c(=O)c3c2c2ccccc2n3C)o1 nan
644549 27694 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 347 4 1 7 2.4 CC(C)OC(=O)CC(=O)c1sc2nc3c(cc2c1N)CN(C)CC3 nan
CHEMBL1370073 27694 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 347 4 1 7 2.4 CC(C)OC(=O)CC(=O)c1sc2nc3c(cc2c1N)CN(C)CC3 nan
2903812 27700 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 0 3 5.5 O=C(C1CCN(Cc2ccc(Cl)cc2)CC1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL1370128 27700 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 487 6 0 3 5.5 O=C(C1CCN(Cc2ccc(Cl)cc2)CC1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 nan
2925605 27705 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 5 1 2 5.6 O=C(CCSc1ccc(Cl)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2 nan
CHEMBL1370162 27705 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 383 5 1 2 5.6 O=C(CCSc1ccc(Cl)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2 nan
651892 27707 None 4 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 8 1 9 5.1 Cc1ccc2cc(C(c3nnnn3C3CCCC3)N(Cc3cccnc3)Cc3ccco3)c(O)nc2c1 nan
CHEMBL1370174 27707 None 4 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 8 1 9 5.1 Cc1ccc2cc(C(c3nnnn3C3CCCC3)N(Cc3cccnc3)Cc3ccco3)c(O)nc2c1 nan
1473623 27727 None 19 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 4 1 4 4.1 Cc1oc(=O)c(NC(=O)c2ccc(Cl)cc2)cc1C(=O)c1ccccc1 nan
CHEMBL1370361 27727 None 19 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 4 1 4 4.1 Cc1oc(=O)c(NC(=O)c2ccc(Cl)cc2)cc1C(=O)c1ccccc1 nan
2944971 27733 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 3 0 5 4.0 CC1CC(C)CN(c2ncnc3c2cnn3Cc2ccc(Cl)cc2)C1 nan
CHEMBL1370391 27733 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 355 3 0 5 4.0 CC1CC(C)CN(c2ncnc3c2cnn3Cc2ccc(Cl)cc2)C1 nan
3152385 27768 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 5 1 4 4.2 Cc1ccc(-c2nn(CC(=O)NC(C)c3ccccc3)c(=O)c3ccccc23)cc1 nan
CHEMBL1370609 27768 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 397 5 1 4 4.2 Cc1ccc(-c2nn(CC(=O)NC(C)c3ccccc3)c(=O)c3ccccc23)cc1 nan
2035866 27780 None 6 Human Functional pPotency = 5 5.0 -4 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1370681 27780 None 6 Human Functional pPotency = 5 5.0 -4 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
664915 27781 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 8 4.0 CCn1c(COc2ccc(Cl)cc2)nnc1SCC(=O)Nc1ccc2c(c1)OCCO2 nan
CHEMBL1370689 27781 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 8 1 8 4.0 CCn1c(COc2ccc(Cl)cc2)nnc1SCC(=O)Nc1ccc2c(c1)OCCO2 nan
649915 27796 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 2 0 6 3.8 Fc1cccc(-c2cc3nc4c(c(N5CCC6(CC5)OCCO6)n3n2)CCCC4)c1 nan
CHEMBL1370759 27796 None 4 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 408 2 0 6 3.8 Fc1cccc(-c2cc3nc4c(c(N5CCC6(CC5)OCCO6)n3n2)CCCC4)c1 nan
2220908 27802 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 2 1 5 4.4 Cc1ccc(-c2cc(C(=O)NC3=NCCS3)c3cc(Br)ccc3n2)o1 nan
CHEMBL1370817 27802 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 2 1 5 4.4 Cc1ccc(-c2cc(C(=O)NC3=NCCS3)c3cc(Br)ccc3n2)o1 nan
2953195 27806 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 2 1 2 4.4 CN=C(S)N1N=C(c2ccccc2)CC1c1ccccc1Cl nan
CHEMBL1370871 27806 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 329 2 1 2 4.4 CN=C(S)N1N=C(c2ccccc2)CC1c1ccccc1Cl nan
701067 27810 None 7 Human Functional pPotency = 5 5.0 -20 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
CHEMBL1370884 27810 None 7 Human Functional pPotency = 5 5.0 -20 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
2299468 27818 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 8 0 5 4.6 Cc1ccc(N(CCCCN2C(=O)c3ccccc3C2=O)C(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
CHEMBL1370982 27818 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 457 8 0 5 4.6 Cc1ccc(N(CCCCN2C(=O)c3ccccc3C2=O)C(=O)c2cccc([N+](=O)[O-])c2)cc1 nan
2443232 27819 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 519 5 1 5 6.4 O=C(COC(=O)c1cc(-c2ccccc2Cl)nc2ccccc12)Nc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1370986 27819 None 3 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 519 5 1 5 6.4 O=C(COC(=O)c1cc(-c2ccccc2Cl)nc2ccccc12)Nc1ncc(C(F)(F)F)cc1Cl nan
1948690 27823 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 4 1 5 4.9 O=C(O)CSc1nc(-c2ccc(Cl)cc2)nc2c1oc1ccccc12 nan
CHEMBL1371004 27823 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 4 1 5 4.9 O=C(O)CSc1nc(-c2ccc(Cl)cc2)nc2c1oc1ccccc12 nan
4832513 27836 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 5 0 7 4.7 Fc1ccc(N2CCN(c3nc(CN4CCOCC4)nc4scc(-c5ccccc5)c34)CC2)cc1 nan
CHEMBL1371114 27836 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 489 5 0 7 4.7 Fc1ccc(N2CCN(c3nc(CN4CCOCC4)nc4scc(-c5ccccc5)c34)CC2)cc1 nan
651596 27843 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 2 5 2.8 CC(=O)Nc1nc2n(n1)C(c1ccc(Cl)cc1)C=C(C)N2 nan
CHEMBL1371159 27843 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 303 2 2 5 2.8 CC(=O)Nc1nc2n(n1)C(c1ccc(Cl)cc1)C=C(C)N2 nan
646842 27846 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 0 8 2.9 Cc1ccc(Cn2nnnc2CN2CCC(n3nnc4cc(C)ccc43)CC2)cc1 nan
CHEMBL1371176 27846 None 0 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 402 5 0 8 2.9 Cc1ccc(Cn2nnnc2CN2CCC(n3nnc4cc(C)ccc43)CC2)cc1 nan
889692 27847 None 36 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 321 7 2 4 4.5 C=CCc1cccc(CNc2nc3ccccc3n2CCC)c1O nan
CHEMBL1371188 27847 None 36 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 321 7 2 4 4.5 C=CCc1cccc(CNc2nc3ccccc3n2CCC)c1O nan
2856996 27853 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 1 0 3 4.7 O=C1CCCC2=C1C(c1ccc(Cl)cc1)C1C(=O)c3ccccc3C1=N2 nan
CHEMBL1371238 27853 None 16 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 361 1 0 3 4.7 O=C1CCCC2=C1C(c1ccc(Cl)cc1)C1C(=O)c3ccccc3C1=N2 nan
2080422 27855 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 6 1 7 3.9 O=C(Nc1ccccc1C(=O)OCc1nnc(-c2ccccc2)o1)c1ccco1 nan
CHEMBL1371247 27855 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 6 1 7 3.9 O=C(Nc1ccccc1C(=O)OCc1nnc(-c2ccccc2)o1)c1ccco1 nan
16197050 27858 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 8 2 4 4.8 O=C(NCc1ccccc1)C1=C[C@@H](C2CCCCC2)C[C@@H](OCc2ccc(CO)cc2)O1 nan
CHEMBL1371269 27858 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 8 2 4 4.8 O=C(NCc1ccccc1)C1=C[C@@H](C2CCCCC2)C[C@@H](OCc2ccc(CO)cc2)O1 nan
1842208 27891 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.4 COc1ccccc1N1C(=O)/C(=C/NCc2ccccn2)c2ccccc2C1=O nan
CHEMBL1371552 27891 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 5 1 5 3.4 COc1ccccc1N1C(=O)/C(=C/NCc2ccccn2)c2ccccc2C1=O nan
646268 27897 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 5 1 6 4.4 Cc1nc2cc(N3CCCCC3)c(NC(=O)c3cccnc3)cc2c(=O)n1Cc1ccccc1 nan
CHEMBL1371615 27897 None 4 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 453 5 1 6 4.4 Cc1nc2cc(N3CCCCC3)c(NC(=O)c3cccnc3)cc2c(=O)n1Cc1ccccc1 nan
5461677 27914 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 658 7 2 4 5.0 CC1=C(C(=O)OCC(Br)(Br)Br)C(c2ccc(Br)cc2)NC(=O)N1CCCC(=O)O nan
CHEMBL1371760 27914 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 658 7 2 4 5.0 CC1=C(C(=O)OCC(Br)(Br)Br)C(c2ccc(Br)cc2)NC(=O)N1CCCC(=O)O nan
2325815 27922 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 4 0 8 1.9 O=c1c2ccccc2sn1-c1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCOCC1 nan
CHEMBL1371792 27922 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 461 4 0 8 1.9 O=c1c2ccccc2sn1-c1cc(S(=O)(=O)N2CCOCC2)ccc1N1CCOCC1 nan
2902133 27930 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 0 3 6.4 CC1(C)CC(C(CCN(Cc2ccccc2)C(=O)c2ccco2)c2ccc(F)cc2)CCO1 nan
CHEMBL1371873 27930 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 8 0 3 6.4 CC1(C)CC(C(CCN(Cc2ccccc2)C(=O)c2ccco2)c2ccc(F)cc2)CCO1 nan
4246771 27956 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 4 0 4 4.8 COc1ccccc1C1CC(c2ccc(Br)cc2)=NN1C(=O)c1cccnc1 nan
CHEMBL1372072 27956 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 435 4 0 4 4.8 COc1ccccc1C1CC(c2ccc(Br)cc2)=NN1C(=O)c1cccnc1 nan
3242057 27960 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 1 1 3 3.5 O=Nc1c2[nH]c3ccccc3[n+]([O-])c-2c2ccccc12 nan
CHEMBL1372085 27960 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 263 1 1 3 3.5 O=Nc1c2[nH]c3ccccc3[n+]([O-])c-2c2ccccc12 nan
2102778 27964 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 5 0 5 3.4 O=C(CSc1ncc(C(F)(F)F)cc1Cl)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
CHEMBL1372108 27964 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 479 5 0 5 3.4 O=C(CSc1ncc(C(F)(F)F)cc1Cl)N1CCN(S(=O)(=O)c2ccccc2)CC1 nan
5706357 27966 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 2 4 2.8 CC(=O)c1sc(C(C)(C)C)cc1NC(=O)/C=C/C(=O)O nan
CHEMBL1372121 27966 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 295 4 2 4 2.8 CC(=O)c1sc(C(C)(C)C)cc1NC(=O)/C=C/C(=O)O nan
788167 27998 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 2 1 3 3.1 CC(=O)n1c(Cl)c(NC(=O)CCl)c2ccccc21 nan
CHEMBL1372356 27998 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 284 2 1 3 3.1 CC(=O)n1c(Cl)c(NC(=O)CCl)c2ccccc21 nan
3245927 28009 None 1 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 7 1 5 3.5 CCCCNC(=O)CSc1nc2ccccc2c(=O)n1C1CCCC1 nan
CHEMBL1372412 28009 None 1 Human Functional pPotency = 5 5.0 -1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 359 7 1 5 3.5 CCCCNC(=O)CSc1nc2ccccc2c(=O)n1C1CCCC1 nan
935066 28012 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 5 3 3 4.5 CCOc1ccc(NC(S)=Nc2cc(-c3ccccc3)[nH]n2)cc1 nan
CHEMBL1372438 28012 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 338 5 3 3 4.5 CCOc1ccc(NC(S)=Nc2cc(-c3ccccc3)[nH]n2)cc1 nan
2837730 28017 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 1 6 3.3 COc1ccc(Nc2c([N+](=O)[O-])ccc3c2=NC2(CCCCC2)N=3)cc1 nan
CHEMBL1372470 28017 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 352 4 1 6 3.3 COc1ccc(Nc2c([N+](=O)[O-])ccc3c2=NC2(CCCCC2)N=3)cc1 nan
2953328 28018 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 6 1 5 5.0 CCCC(=O)Nc1cc(-c2nnc(OC)c3ccccc23)ccc1N1CCCCC1 nan
CHEMBL1372474 28018 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 404 6 1 5 5.0 CCCC(=O)Nc1cc(-c2nnc(OC)c3ccccc23)ccc1N1CCCCC1 nan
648869 28027 None 2 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 369 5 0 5 3.9 CCOc1ccc2cc(C#N)c(SCC(=O)N3CCC(C)CC3)nc2c1 nan
CHEMBL1372547 28027 None 2 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 369 5 0 5 3.9 CCOc1ccc2cc(C#N)c(SCC(=O)N3CCC(C)CC3)nc2c1 nan
1355735 28030 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 5 2 4 4.7 O=C(Nc1ccccc1-c1nc2ccccc2[nH]1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1372577 28030 None 12 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 460 5 2 4 4.7 O=C(Nc1ccccc1-c1nc2ccccc2[nH]1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
645389 28032 None 15 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 3 0 7 1.7 CC1CCN(c2nc3c(c(=O)n(C)c(=O)n3C)n2Cc2ccccc2)CC1 nan
CHEMBL1372584 28032 None 15 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 367 3 0 7 1.7 CC1CCN(c2nc3c(c(=O)n(C)c(=O)n3C)n2Cc2ccccc2)CC1 nan
3709592 28039 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 5 0 8 4.8 CCOC(=O)C1=NN(c2ccccc2)C2(S1)SC(C(C)=O)=C(C)N2c1ccccc1 nan
CHEMBL1372610 28039 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 439 5 0 8 4.8 CCOC(=O)C1=NN(c2ccccc2)C2(S1)SC(C(C)=O)=C(C)N2c1ccccc1 nan
2443473 28052 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 1 4 3.0 CCC(C)(C)NC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C2=O nan
CHEMBL1372729 28052 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 1 4 3.0 CCC(C)(C)NC(=O)c1ccc2c(c1)S(=O)(=O)c1ccccc1C2=O nan
3225064 28065 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 6 0 4 4.4 CCC1Oc2ccc(C)cc2N(CC(=O)N(Cc2ccc(C)o2)C2CCCC2)C1=O nan
CHEMBL1372781 28065 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 6 0 4 4.4 CCC1Oc2ccc(C)cc2N(CC(=O)N(Cc2ccc(C)o2)C2CCCC2)C1=O nan
828742 28070 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 0 6 2.5 CCS(=O)(=O)n1nc(-c2ccc(Cl)cc2)nc1SC nan
CHEMBL1372804 28070 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 4 0 6 2.5 CCS(=O)(=O)n1nc(-c2ccc(Cl)cc2)nc1SC nan
4067241 28071 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 5 3 4 5.5 Cc1ccc(NS(=O)(=O)c2ccc(Cl)c(NC(=S)NC(=O)C3CCCCC3)c2)cc1Cl nan
CHEMBL1372805 28071 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 499 5 3 4 5.5 Cc1ccc(NS(=O)(=O)c2ccc(Cl)c(NC(=S)NC(=O)C3CCCCC3)c2)cc1Cl nan
664361 28074 None 8 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 5 4.4 Cc1nc(SCC(=O)Nc2ccccc2)c2oc3ccccc3c2n1 nan
CHEMBL1372818 28074 None 8 Human Functional pPotency = 5 5.0 1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 349 4 1 5 4.4 Cc1nc(SCC(=O)Nc2ccccc2)c2oc3ccccc3c2n1 nan
3561847 28082 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 5 1 6 3.9 Cc1sc(NC(=O)c2ccco2)c(C(c2cccnc2)N2CCN(C)CC2)c1C nan
CHEMBL1372883 28082 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 410 5 1 6 3.9 Cc1sc(NC(=O)c2ccco2)c(C(c2cccnc2)N2CCN(C)CC2)c1C nan
749168 28105 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 269 2 0 3 3.6 CC(C)c1nc(N2CCCC2)c(C#N)c2c1CCCC2 nan
CHEMBL1373002 28105 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 269 2 0 3 3.6 CC(C)c1nc(N2CCCC2)c(C#N)c2c1CCCC2 nan
2999023 28137 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 7 0 8 5.2 Cc1sc2nc(SCC(=O)c3cc(C)n(CC4CCCO4)c3C)n(C(C)C)c(=O)c2c1C nan
CHEMBL1373222 28137 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 473 7 0 8 5.2 Cc1sc2nc(SCC(=O)c3cc(C)n(CC4CCCO4)c3C)n(C(C)C)c(=O)c2c1C nan
2904000 28164 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 4 0 3 6.8 CC1CC(N(C(=O)c2ccc(Cl)cc2)c2ccccc2)c2ccccc2N1C(=O)c1ccco1 nan
CHEMBL1373385 28164 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 470 4 0 3 6.8 CC1CC(N(C(=O)c2ccc(Cl)cc2)c2ccccc2)c2ccccc2N1C(=O)c1ccco1 nan
1366616 28178 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 5 0 6 2.9 O=C1c2ccccc2C(=O)N1CCc1nc2ccccc2c(=O)n1Cc1ccco1 nan
CHEMBL1373492 28178 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 5 0 6 2.9 O=C1c2ccccc2C(=O)N1CCc1nc2ccccc2c(=O)n1Cc1ccco1 nan
654428 28186 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 2 1 4 4.2 O=C(Nc1nc2c(s1)CCc1ccccc1-2)c1cccs1 nan
CHEMBL1373547 28186 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 312 2 1 4 4.2 O=C(Nc1nc2c(s1)CCc1ccccc1-2)c1cccs1 nan
5922244 28196 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 8 1 8 4.3 CCCOc1ccc(C(=O)C2=C(O)C(=O)N(c3cc(C)on3)C2c2ccc(C(=O)OC)cc2)cc1 nan
CHEMBL1373602 28196 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 476 8 1 8 4.3 CCCOc1ccc(C(=O)C2=C(O)C(=O)N(c3cc(C)on3)C2c2ccc(C(=O)OC)cc2)cc1 nan
16187149 28197 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 562 9 1 7 4.3 O=C(C1=C[C@@H](c2ccc(C(F)(F)F)cc2)C[C@@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
CHEMBL1373604 28197 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 562 9 1 7 4.3 O=C(C1=C[C@@H](c2ccc(C(F)(F)F)cc2)C[C@@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
9549698 28208 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 4 1 4 3.3 CC1=NN(c2cccc(C(=O)O)c2)C(=O)/C1=C\C=C\c1ccco1 nan
CHEMBL1373655 28208 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 4 1 4 3.3 CC1=NN(c2cccc(C(=O)O)c2)C(=O)/C1=C\C=C\c1ccco1 nan
2953159 28213 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 0 2 5 3.7 Cc1ccc2c3c1C1(C(=O)N3C(C)(C)CC2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
CHEMBL1373682 28213 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 0 2 5 3.7 Cc1ccc2c3c1C1(C(=O)N3C(C)(C)CC2C)C(C#N)=C(N)Oc2cc(O)ccc21 nan
2225058 28229 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 2 7 1.2 COCCNC(=O)c1ccccc1NC(=O)CN(c1ccc2c(c1)OCO2)S(C)(=O)=O nan
CHEMBL1373805 28229 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 2 7 1.2 COCCNC(=O)c1ccccc1NC(=O)CN(c1ccc2c(c1)OCO2)S(C)(=O)=O nan
1772756 28239 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 4 2 6 5.5 CC(C)NC(=O)c1sc2nc(-c3cccs3)cc(-c3cccs3)c2c1N nan
CHEMBL1373882 28239 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 399 4 2 6 5.5 CC(C)NC(=O)c1sc2nc(-c3cccs3)cc(-c3cccs3)c2c1N nan
3190231 28244 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 9 1 9 3.3 O=C(NCC1CCCO1)C(c1cccs1)N(C(=O)Cn1nnc(-c2cccs2)n1)C1CCCC1 nan
CHEMBL1373925 28244 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 500 9 1 9 3.3 O=C(NCC1CCCO1)C(c1cccs1)N(C(=O)Cn1nnc(-c2cccs2)n1)C1CCCC1 nan
649129 28262 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 2 4 4.9 CCN1CCCC1CN(Cc1cc2c(C)cc(C)cc2nc1O)C(=O)NC1CCCCC1 nan
CHEMBL1374119 28262 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 438 6 2 4 4.9 CCN1CCCC1CN(Cc1cc2c(C)cc(C)cc2nc1O)C(=O)NC1CCCCC1 nan
645287 28268 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 6 1 5 2.7 Cc1ccc2c(c1)nnn2C1CCN(CC(=O)NCCc2ccccc2)CC1 nan
CHEMBL1374175 28268 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 377 6 1 5 2.7 Cc1ccc2c(c1)nnn2C1CCN(CC(=O)NCCc2ccccc2)CC1 nan
663879 28279 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 1 7 4.2 Cc1ccc(C(=O)C2=C(O)C(=O)N(CCCn3ccnc3)C2c2ccc(OC(C)C)cc2)o1 nan
CHEMBL1374204 28279 None 11 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 449 9 1 7 4.2 Cc1ccc(C(=O)C2=C(O)C(=O)N(CCCn3ccnc3)C2c2ccc(OC(C)C)cc2)o1 nan
3878372 28280 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 0 5 5.0 CCc1nc(SCC(=O)N2CCCc3ccccc32)c2oc3ccccc3c2n1 nan
CHEMBL1374205 28280 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 403 4 0 5 5.0 CCc1nc(SCC(=O)N2CCCc3ccccc32)c2oc3ccccc3c2n1 nan
660358 28283 None 16 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 6 1 8 4.8 CCOC(=O)c1sc(NC(=O)CSc2nc3c(cc2C#N)CCCCCC3)c(C#N)c1C nan
CHEMBL1374224 28283 None 16 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 468 6 1 8 4.8 CCOC(=O)c1sc(NC(=O)CSc2nc3c(cc2C#N)CCCCCC3)c(C#N)c1C nan
5196684 28289 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 8 1 5 4.7 CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)Cc1cccc2ccccc12 nan
CHEMBL1374255 28289 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 8 1 5 4.7 CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)Cc1cccc2ccccc12 nan
664783 28305 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 323 5 1 5 4.0 COc1ccccc1-c1nc(C#N)c(NCc2ccc(F)cc2)o1 nan
CHEMBL1374386 28305 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 323 5 1 5 4.0 COc1ccccc1-c1nc(C#N)c(NCc2ccc(F)cc2)o1 nan
3239872 28314 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 4 5.0 Cc1nn(Cc2ccc(C(=O)N3c4ccc(F)cc4CCC3C)o2)c(C)c1Br nan
CHEMBL1374444 28314 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 3 0 4 5.0 Cc1nn(Cc2ccc(C(=O)N3c4ccc(F)cc4CCC3C)o2)c(C)c1Br nan
3241034 28316 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 5 1 8 3.9 CCn1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2c(c1=O)SC(C)C2 nan
CHEMBL1374456 28316 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 432 5 1 8 3.9 CCn1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2c(c1=O)SC(C)C2 nan
835923 28337 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 4 1 4 3.3 CCOC(=O)c1ccccc1NC(=O)c1cncc(Br)c1 nan
CHEMBL1374609 28337 None 12 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 348 4 1 4 3.3 CCOC(=O)c1ccccc1NC(=O)c1cncc(Br)c1 nan
1303207 28339 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 9 1 5 5.1 Cc1ccc(-n2c(CCc3ccccc3)nnc2SCC(=O)NCc2ccccc2)cc1C nan
CHEMBL1374622 28339 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 456 9 1 5 5.1 Cc1ccc(-n2c(CCc3ccccc3)nnc2SCC(=O)NCc2ccccc2)cc1C nan
3236624 28341 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 4 0 6 3.9 Cc1ccc(CN2CCSc3ccc(C(=O)N4CCN(c5ncccn5)CC4)cc32)cc1 nan
CHEMBL1374633 28341 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 445 4 0 6 3.9 Cc1ccc(CN2CCSc3ccc(C(=O)N4CCN(c5ncccn5)CC4)cc32)cc1 nan
644956 28354 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 1 5 3.5 Cc1cccc2cc(C#N)c(SCC(=O)N3CC(=O)Nc4ccccc43)nc12 nan
CHEMBL1374715 28354 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 1 5 3.5 Cc1cccc2cc(C#N)c(SCC(=O)N3CC(=O)Nc4ccccc43)nc12 nan
787181 28362 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 3 1.8 CS(=O)(=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 nan
CHEMBL1374766 28362 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 322 3 0 3 1.8 CS(=O)(=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 nan
654252 28369 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 9 0 9 2.7 COc1ccccc1CN(Cc1ccco1)S(=O)(=O)c1ccc(-n2cnnn2)c(OC)c1 nan
CHEMBL1374812 28369 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 455 9 0 9 2.7 COc1ccccc1CN(Cc1ccco1)S(=O)(=O)c1ccc(-n2cnnn2)c(OC)c1 nan
1363467 28392 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 5 1 3 4.7 COc1ccc(Br)cc1C(=O)Nc1ccc(Cc2ccncc2)cc1 nan
CHEMBL1374962 28392 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 396 5 1 3 4.7 COc1ccc(Br)cc1C(=O)Nc1ccc(Cc2ccncc2)cc1 nan
16197053 28399 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 7 2 4 5.5 O=C(Nc1ccccc1)C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCc2ccc(CO)cc2)O1 nan
CHEMBL1375007 28399 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 493 7 2 4 5.5 O=C(Nc1ccccc1)C1=C[C@@H](c2ccc(Br)cc2)C[C@@H](OCc2ccc(CO)cc2)O1 nan
2950223 28407 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 4 5.0 O=S(=O)(NC(=Nc1cccc2ccccc12)c1ccccc1)c1cccs1 nan
5739175 28407 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 4 5.0 O=S(=O)(NC(=Nc1cccc2ccccc12)c1ccccc1)c1cccs1 nan
5922464 28407 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 4 5.0 O=S(=O)(NC(=Nc1cccc2ccccc12)c1ccccc1)c1cccs1 nan
CHEMBL1375073 28407 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 4 5.0 O=S(=O)(NC(=Nc1cccc2ccccc12)c1ccccc1)c1cccs1 nan
659479 28410 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 4 2 5 3.6 C=CCn1c(N)c(C(=O)Nc2ccccc2)c2nc3ccccc3nc21 nan
CHEMBL1375094 28410 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 343 4 2 5 3.6 C=CCn1c(N)c(C(=O)Nc2ccccc2)c2nc3ccccc3nc21 nan
3571741 28411 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 4 1 4 4.6 Cc1ccc(-c2cc(C(=O)NCc3cnn(C)c3)c3cc(Br)ccc3n2)cc1 nan
CHEMBL1375116 28411 None 9 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 434 4 1 4 4.6 Cc1ccc(-c2cc(C(=O)NCc3cnn(C)c3)c3cc(Br)ccc3n2)cc1 nan
1357768 28416 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 505 8 1 4 5.4 Cc1ccc(Cl)cc1N(Cc1ccc(C(=O)NCc2cccnc2)cc1)S(=O)(=O)c1ccccc1 nan
CHEMBL1375153 28416 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 505 8 1 4 5.4 Cc1ccc(Cl)cc1N(Cc1ccc(C(=O)NCc2cccnc2)cc1)S(=O)(=O)c1ccccc1 nan
2566824 28443 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 7 1 10 3.5 Cc1cc(C(=O)CSc2nnnn2-c2ccc(O)cc2)c(C)n1Cc1ccc2c(c1)OCO2 nan
CHEMBL1375326 28443 None 3 Human Functional pPotency = 5 5.0 3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 7 1 10 3.5 Cc1cc(C(=O)CSc2nnnn2-c2ccc(O)cc2)c(C)n1Cc1ccc2c(c1)OCO2 nan
2987363 28445 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 2 0 4 2.7 CS(=O)(=O)c1nc(-c2ccc(F)cc2)cc(C(F)(F)F)n1 nan
CHEMBL1375338 28445 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 320 2 0 4 2.7 CS(=O)(=O)c1nc(-c2ccc(F)cc2)cc(C(F)(F)F)n1 nan
2742154 28447 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 535 4 0 6 4.9 COC(=O)CC1(C(=O)OC)Oc2ccc(Br)cc2C(=O)N1c1cc(Cl)c(Cl)cc1Cl nan
CHEMBL1375349 28447 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 535 4 0 6 4.9 COC(=O)CC1(C(=O)OC)Oc2ccc(Br)cc2C(=O)N1c1cc(Cl)c(Cl)cc1Cl nan
2945145 28457 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 2 0 5 5.0 O=C1CC(c2ccccc2Cl)Cc2c1cnn2-c1nc2ccccc2s1 nan
CHEMBL1375379 28457 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 379 2 0 5 5.0 O=C1CC(c2ccccc2Cl)Cc2c1cnn2-c1nc2ccccc2s1 nan
1017652 28468 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 1 4 3.0 CC(C)C(=O)N1CCN(c2ccccc2NC(=O)COc2ccccc2)CC1 nan
CHEMBL1375484 28468 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 381 6 1 4 3.0 CC(C)C(=O)N1CCN(c2ccccc2NC(=O)COc2ccccc2)CC1 nan
2743471 28471 None 19 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 276 2 1 4 3.7 CSc1cc(-c2ccc(Cl)cc2)nc(O)c1C#N nan
CHEMBL1375507 28471 None 19 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 276 2 1 4 3.7 CSc1cc(-c2ccc(Cl)cc2)nc(O)c1C#N nan
6409081 28473 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 2 0 3 4.8 Cc1ccc(-c2nnc(N3CCC(C)CC3)c3ccccc23)cc1 nan
CHEMBL1375532 28473 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 2 0 3 4.8 Cc1ccc(-c2nnc(N3CCC(C)CC3)c3ccccc23)cc1 nan
3243697 28479 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 7 2 5 3.5 COc1ccc(N(CC(=O)Nc2ccc(C)c(C)c2)S(=O)(=O)c2c(C)n[nH]c2C)cc1 nan
CHEMBL1375558 28479 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 7 2 5 3.5 COc1ccc(N(CC(=O)Nc2ccc(C)c(C)c2)S(=O)(=O)c2c(C)n[nH]c2C)cc1 nan
6224263 28488 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 7 0 5 4.8 O=C(Cn1c(N2CCN(C/C=C/c3ccccc3)CC2)nc2ccccc21)c1ccccc1 nan
CHEMBL1375630 28488 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 436 7 0 5 4.8 O=C(Cn1c(N2CCN(C/C=C/c3ccccc3)CC2)nc2ccccc21)c1ccccc1 nan
2471579 28490 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 9 2 7 5.5 COc1ccc(-c2nc(NC(=O)c3ccc(OCC(=O)Nc4ccc(F)cc4)c(OC)c3)sc2C)cc1 nan
CHEMBL1375669 28490 None 6 Human Functional pPotency = 5 5.0 2 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 521 9 2 7 5.5 COc1ccc(-c2nc(NC(=O)c3ccc(OCC(=O)Nc4ccc(F)cc4)c(OC)c3)sc2C)cc1 nan
1487198 28498 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 7 2 3 5.0 COc1cccc(CNCC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 nan
CHEMBL1375741 28498 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 7 2 3 5.0 COc1cccc(CNCC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1 nan
1857812 28503 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 3 0 5 4.1 Cn1c2ccccc2c(=O)c2c(=O)n(Cc3ccccc3)c(-c3ccc(F)cc3)nc21 nan
CHEMBL1375758 28503 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 3 0 5 4.1 Cn1c2ccccc2c(=O)c2c(=O)n(Cc3ccccc3)c(-c3ccc(F)cc3)nc21 nan
666790 28510 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 7 5.6 O=C(CSc1nnc(Cc2cccs2)n1Cc1ccco1)Nc1cc(Cl)cc(Cl)c1 nan
CHEMBL1375824 28510 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 7 5.6 O=C(CSc1nnc(Cc2cccs2)n1Cc1ccco1)Nc1cc(Cl)cc(Cl)c1 nan
3241220 28513 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 1 6 1.4 O=C(Cn1cnc2c(oc3ccccc32)c1=O)NCC1CCCO1 nan
CHEMBL1375857 28513 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 327 4 1 6 1.4 O=C(Cn1cnc2c(oc3ccccc32)c1=O)NCC1CCCO1 nan
2024778 28516 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 3 2 5 4.6 COc1ccc2[nH]c3c(N4CCC(O)(c5cccc(C(F)(F)F)c5)CC4)ncnc3c2c1 nan
CHEMBL1375894 28516 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 442 3 2 5 4.6 COc1ccc2[nH]c3c(N4CCC(O)(c5cccc(C(F)(F)F)c5)CC4)ncnc3c2c1 nan
662329 28525 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 0 7 1.2 Cn1c(N2CCCC2)nc2c1c(=O)n(Cc1ccc(F)cc1)c(=O)n2C nan
CHEMBL1376013 28525 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 357 3 0 7 1.2 Cn1c(N2CCCC2)nc2c1c(=O)n(Cc1ccc(F)cc1)c(=O)n2C nan
651552 28531 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 4 0 8 3.9 Cc1nn(-c2ccccc2)c(Cl)c1C(=O)N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 nan
CHEMBL1376120 28531 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 498 4 0 8 3.9 Cc1nn(-c2ccccc2)c(Cl)c1C(=O)N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 nan
2101735 28563 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 6 0 5 5.1 CC(C)N(C(=O)CSc1ncnc2sc(-c3ccccc3)cc12)C(C)C nan
CHEMBL1376400 28563 None 2 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 385 6 0 5 5.1 CC(C)N(C(=O)CSc1ncnc2sc(-c3ccccc3)cc12)C(C)C nan
4094375 28578 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 3 1 5 3.6 O=c1c2cc(N3CCOCC3)ccc2[nH]c(=S)n1Cc1ccc(Cl)cc1 nan
CHEMBL1376513 28578 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 387 3 1 5 3.6 O=c1c2cc(N3CCOCC3)ccc2[nH]c(=S)n1Cc1ccc(Cl)cc1 nan
4882169 28590 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 5 1 4 4.7 Cc1ccc(NC(=O)C(OC(=O)c2cc(C)oc2C)c2ccccc2)cc1 nan
CHEMBL1376585 28590 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 363 5 1 4 4.7 Cc1ccc(NC(=O)C(OC(=O)c2cc(C)oc2C)c2ccccc2)cc1 nan
2818996 28592 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 6 4.9 COc1ccc(-c2c(C#N)c(N)nc(Sc3ccc(Cl)cc3)c2C#N)cc1 nan
CHEMBL1376612 28592 None 2 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 392 4 1 6 4.9 COc1ccc(-c2c(C#N)c(N)nc(Sc3ccc(Cl)cc3)c2C#N)cc1 nan
2997664 28597 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 6 0 8 3.9 C=CCn1c(SCc2c(C)noc2C)nnc1C1COc2ccccc2O1 nan
CHEMBL1376664 28597 None 4 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 384 6 0 8 3.9 C=CCn1c(SCc2c(C)noc2C)nnc1C1COc2ccccc2O1 nan
2231882 28607 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 4 4.9 Cc1ccc(SCCNC(=O)c2ccc(C)c(S(=O)(=O)Nc3ccccc3C)c2)cc1 nan
CHEMBL1376755 28607 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 4 4.9 Cc1ccc(SCCNC(=O)c2ccc(C)c(S(=O)(=O)Nc3ccccc3C)c2)cc1 nan
3191217 28610 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 5 5.1 CCc1ccc(N(C(=O)Cc2cccs2)C(C(=O)NC2CCCCC2)c2cn(C)nc2C)cc1 nan
CHEMBL1376782 28610 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 478 8 1 5 5.1 CCc1ccc(N(C(=O)Cc2cccs2)C(C(=O)NC2CCCCC2)c2cn(C)nc2C)cc1 nan
2371253 28616 None 2 Human Functional pPotency = 5 5.0 -1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 7 1 6 4.5 O=C(COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1)NC1CCCCCC1 nan
CHEMBL1376861 28616 None 2 Human Functional pPotency = 5 5.0 -1 3
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 458 7 1 6 4.5 O=C(COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1)NC1CCCCCC1 nan
1844663 28625 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 0 3 4.2 C#CCOc1ccc2c(c1)c(C(C)=O)c(C)n2Cc1ccccc1 nan
CHEMBL1376992 28625 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 317 5 0 3 4.2 C#CCOc1ccc2c(c1)c(C(C)=O)c(C)n2Cc1ccccc1 nan
2982874 28628 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 9 1 5 4.2 CCOC(=O)c1ccc(NC(=O)CC2C(=O)N(c3ccc(F)cc3)C(=O)N2CCC(C)C)cc1 nan
CHEMBL1377024 28628 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 469 9 1 5 4.2 CCOC(=O)c1ccc(NC(=O)CC2C(=O)N(c3ccc(F)cc3)C(=O)N2CCC(C)C)cc1 nan
653536 28659 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 272 1 1 3 2.8 O=C(Nc1cc(=O)c2ccccc2o1)N1CCCCC1 nan
CHEMBL1377309 28659 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 272 1 1 3 2.8 O=C(Nc1cc(=O)c2ccccc2o1)N1CCCCC1 nan
6175808 28661 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 7 0 3 5.5 COc1ccc(C(=O)C/C(=C\C(=O)c2ccc(C)cc2)c2ccccc2)cc1 nan
CHEMBL1377336 28661 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 370 7 0 3 5.5 COc1ccc(C(=O)C/C(=C\C(=O)c2ccc(C)cc2)c2ccccc2)cc1 nan
2139614 28686 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 1 8 4.1 CCOC(=O)c1c(NC(=O)CSc2nnc(C)s2)sc2c1CCCCC2 nan
CHEMBL1377637 28686 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 411 6 1 8 4.1 CCOC(=O)c1c(NC(=O)CSc2nnc(C)s2)sc2c1CCCCC2 nan
4673693 28739 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 4 1 4 3.8 CC(C)(C)C(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1N1CCCCC1 nan
CHEMBL1378045 28739 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 407 4 1 4 3.8 CC(C)(C)C(=O)Nc1cc(S(=O)(=O)N2CCCCC2)ccc1N1CCCCC1 nan
4396139 28749 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 223 3 1 4 1.6 CC(=O)Nc1ccc(N(C)C)cc1[N+](=O)[O-] nan
CHEMBL1378142 28749 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 223 3 1 4 1.6 CC(=O)Nc1ccc(N(C)C)cc1[N+](=O)[O-] nan
993248 28761 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 4 0 5 4.4 O=C(CSc1nc(-c2ccco2)cc(C(F)(F)F)n1)N1CCc2ccccc2C1 nan
CHEMBL1378258 28761 None 9 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 419 4 0 5 4.4 O=C(CSc1nc(-c2ccco2)cc(C(F)(F)F)n1)N1CCc2ccccc2C1 nan
2920315 28767 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 9 0 3 5.7 CCC(=O)N(CCC(Cc1ccccc1)c1ccc2c(c1)OCO2)Cc1ccccc1F nan
CHEMBL1378331 28767 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 433 9 0 3 5.7 CCC(=O)N(CCC(Cc1ccccc1)c1ccc2c(c1)OCO2)Cc1ccccc1F nan
669588 28781 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 275 2 1 3 3.3 O=C(Nc1ccc(Cl)cc1)c1ccc2c(c1)OCO2 nan
CHEMBL1378442 28781 None 13 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 275 2 1 3 3.3 O=C(Nc1ccc(Cl)cc1)c1ccc2c(c1)OCO2 nan
646101 28793 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 6 0 7 3.4 CCOC(=O)c1ccc(S(=O)(=O)n2c(CN3CCCCC3)nc3ccccc32)cc1 nan
CHEMBL1378627 28793 None 1 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 427 6 0 7 3.4 CCOC(=O)c1ccc(S(=O)(=O)n2c(CN3CCCCC3)nc3ccccc32)cc1 nan
5717745 28794 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 5 3 2 5.8 O=C(/C=C/c1ccccc1)NC(NC(=S)Nc1ccc(Cl)cc1Cl)C(Cl)(Cl)Cl nan
CHEMBL1378644 28794 None 4 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 495 5 3 2 5.8 O=C(/C=C/c1ccccc1)NC(NC(=S)Nc1ccc(Cl)cc1Cl)C(Cl)(Cl)Cl nan
2695487 28801 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 9 1 6 3.9 CCOc1ccc(S(=O)(=O)N(CC(=O)Nc2cc(C)on2)Cc2ccccc2Cl)cc1 nan
CHEMBL1378711 28801 None 3 Human Functional pPotency = 5 5.0 -3 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 463 9 1 6 3.9 CCOc1ccc(S(=O)(=O)N(CC(=O)Nc2cc(C)on2)Cc2ccccc2Cl)cc1 nan
3695829 28806 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 570 4 0 6 4.3 O=C(CN1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1 nan
CHEMBL1378745 28806 None 20 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 570 4 0 6 4.3 O=C(CN1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1 nan
3180839 28823 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 10 1 7 3.5 Cc1ccc(N(C(=O)Cn2nnc(-c3ccc(F)cc3)n2)C(CC(C)C)C(=O)NCC2CCCO2)cc1 nan
CHEMBL1378878 28823 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 508 10 1 7 3.5 Cc1ccc(N(C(=O)Cn2nnc(-c3ccc(F)cc3)n2)C(CC(C)C)C(=O)NCC2CCCO2)cc1 nan
2124916 28831 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 2 6 3.3 NC(=O)c1ccsc1NC(=O)c1nc(-c2ccccc2)n(-c2ccccc2)n1 nan
CHEMBL1378972 28831 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 389 5 2 6 3.3 NC(=O)c1ccsc1NC(=O)c1nc(-c2ccccc2)n(-c2ccccc2)n1 nan
5206893 28845 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 1 4 3.0 CNC(=S)N(Cc1ccc(OC)cc1)C1CC(=O)N(c2ccc(Cl)cc2)C1=O nan
CHEMBL1379059 28845 None 8 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 417 5 1 4 3.0 CNC(=S)N(Cc1ccc(OC)cc1)C1CC(=O)N(c2ccc(Cl)cc2)C1=O nan
5610485 28850 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 2 1 2 5.1 Cc1cccc(-[n+]2c(-c3cccc(Br)c3)[nH]c3nc4ccccc4nc32)c1 nan
CHEMBL1379115 28850 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 415 2 1 2 5.1 Cc1cccc(-[n+]2c(-c3cccc(Br)c3)[nH]c3nc4ccccc4nc32)c1 nan
16745799 28881 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 591 8 3 5 5.7 CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)C(=O)c4c[nH]c5ccccc45)c3)cc2C(F)(F)F)CC1 nan
CHEMBL1379342 28881 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 591 8 3 5 5.7 CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)C(=O)c4c[nH]c5ccccc45)c3)cc2C(F)(F)F)CC1 nan
3184394 28888 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 6 1 9 3.3 COC(=O)c1c(NC(=O)CSc2nnc(-c3ccco3)n2C)sc(C)c1C nan
CHEMBL1379381 28888 None 3 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 406 6 1 9 3.3 COC(=O)c1c(NC(=O)CSc2nnc(-c3ccco3)n2C)sc(C)c1C nan
645644 28893 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 0 5 3.9 CCOC(=O)c1cc2sccc2n1CC(=O)N1CCCc2ccccc21 nan
CHEMBL1379438 28893 None 1 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 368 4 0 5 3.9 CCOC(=O)c1cc2sccc2n1CC(=O)N1CCCc2ccccc21 nan
2960371 28896 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 1 5 5.3 CCC(Oc1nc2ccccc2nc1-c1ccccc1NC(C)=O)C(=O)c1ccccc1 nan
CHEMBL1379453 28896 None 10 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 425 7 1 5 5.3 CCC(Oc1nc2ccccc2nc1-c1ccccc1NC(C)=O)C(=O)c1ccccc1 nan
2956028 28901 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 307 3 2 3 3.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)Nc1ccc(F)cc1F nan
CHEMBL1379493 28901 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 307 3 2 3 3.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)Nc1ccc(F)cc1F nan
6623196 28902 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 0 5 4.2 COC(=O)c1cc2oc3ccccc3c2n1CC(=O)N1CCCc2ccccc21 nan
CHEMBL1379498 28902 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 388 3 0 5 4.2 COC(=O)c1cc2oc3ccccc3c2n1CC(=O)N1CCCc2ccccc21 nan
665796 28909 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 326 4 1 7 3.0 CCOc1cccc(-c2nn3c(-c4cc(C)[nH]n4)nnc3s2)c1 nan
CHEMBL1379559 28909 None 5 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 326 4 1 7 3.0 CCOc1cccc(-c2nn3c(-c4cc(C)[nH]n4)nnc3s2)c1 nan
2933309 28910 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 6 4.8 CCOC(=O)c1c(NC(=O)C(Sc2ccccc2)c2ccccc2)sc(C(N)=O)c1C nan
CHEMBL1379579 28910 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 454 8 2 6 4.8 CCOC(=O)c1c(NC(=O)C(Sc2ccccc2)c2ccccc2)sc(C(N)=O)c1C nan
667108 28914 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 9 1 8 4.7 COc1ccc(-c2oc3ncnc(NCCCN4CCOCC4)c3c2-c2ccc(OC)cc2)cc1 nan
CHEMBL1379646 28914 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 474 9 1 8 4.7 COc1ccc(-c2oc3ncnc(NCCCN4CCOCC4)c3c2-c2ccc(OC)cc2)cc1 nan
1277344 28936 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 0 7 4.8 C=CCn1c(SCc2c(C)noc2C)nc2sc3c(c2c1=O)CCCCC3 nan
CHEMBL1379817 28936 None 11 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 401 5 0 7 4.8 C=CCn1c(SCc2c(C)noc2C)nc2sc3c(c2c1=O)CCCCC3 nan
16187130 28941 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 550 9 1 8 4.5 O=C(C1=C[C@@H](c2csc3ccccc23)C[C@@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
CHEMBL1379856 28941 None 0 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 550 9 1 8 4.5 O=C(C1=C[C@@H](c2csc3ccccc23)C[C@@H](OCCCCO)O1)N1CCN(Cc2ccc3c(c2)OCO3)CC1 nan
694547 28945 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 266 2 0 5 2.2 CN(C)c1ccc(C(=O)n2nnc3ccccc32)cc1 nan
CHEMBL1379902 28945 None 6 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 266 2 0 5 2.2 CN(C)c1ccc(C(=O)n2nnc3ccccc32)cc1 nan
2300422 28956 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 9 1 3 4.7 O=C(CN(Cc1ccccc1F)S(=O)(=O)c1ccc(Cl)cc1)NCCC1=CCCCC1 nan
CHEMBL1380049 28956 None 7 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 464 9 1 3 4.7 O=C(CN(Cc1ccccc1F)S(=O)(=O)c1ccc(Cl)cc1)NCCC1=CCCCC1 nan
742979 28972 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 5 0 2 4.6 CCCN(CCC)C(=O)C1c2ccccc2Oc2ccccc21 nan
CHEMBL1380219 28972 None 7 Human Functional pPotency = 5 5.0 1 2
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 309 5 0 2 4.6 CCCN(CCC)C(=O)C1c2ccccc2Oc2ccccc21 nan
5389304 28974 None 9 Human Functional pPotency = 5 5.0 - 1
PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)
ChEMBL 431 7 1 7 2.7 Cc1c(C(=O)C2=C(O)C(=O)N(CCN(C)C)C2c2cccnc2)cnn1-c1ccccc1 nan
CHEMBL1380243 28974 None 9 Human Functional pPotency = 5 5.0 - 1