Biased Signaling Atlas

The Biased Signaling Atlas offers:

Biased signaling entails hormones, probes, or drugs binding the same GPCR but engaging different intracellular signaling pathways leading to distinct functional outcomes. This may let drugs favor therapeutic over adverse signal pathways.


  • Biased ligands
  • 128 Physiology-biased
  • 128 Pathway-biased
  • 8,399 Total datapoints
  • Pathways
  • 309 Pathway effects
  • Pathway-preferring ligands
  • 1,665 Ligands
  • Reference ligands
  • 92 For pathway-bias
  • 790 For physiology-bias


The Biased Signaling Atlas is a new community platform.
Read the article, try it out and let us know what you think.

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.


A community Biased Signaling Atlas.
Caroli J, Mamyrbekov A, Harpsøe K, Gardizi S, Dörries L, Ghosh E, Hauser AS, Kooistra AJ & Gloriam DE
Nature Chemical Biology, 2023