Biased Signaling Atlas

The Biased Signaling Atlas offers:


Biased signaling entails hormones, probes, or drugs binding the same GPCR but engaging different intracellular signaling pathways leading to distinct functional outcomes. This may let drugs favor therapeutic over adverse signal pathways.

Data

  • Biased ligands
  • 135 Physiology-biased
  • 135 Pathway-biased
  • 8,616 Total datapoints
  • Pathways
  • 315 Pathway effects
  • Pathway-preferring ligands
  • 1,672 Ligands
  • Reference ligands
  • 94 For pathway-bias
  • 673 For physiology-bias

Welcome

The Biased Signaling Atlas is a new community platform. Publication is planned for end of 2022, meanwhile try it out and let us know what you think.

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases. Together, they have served 6,090/51,885 users in the last month/year (Google Analytics)