Biased ligands
Biased ligands, receptor pathways coverage & bias rank orders.
Pathway effects
Pathway effects and therapeutic relevance.
Reference ligands
Reference ligands for pathway-/physiology-bias.
Bias calculation spreadsheet
Swifty calculate bias factors.
Data deposition
Deposit biased ligands & pathway effects.
Biased Signaling Atlas
Biased signaling entails hormones, probes, or drugs binding the same GPCR but engaging different intracellular
signaling pathways leading to distinct functional outcomes. This may let drugs favor therapeutic over adverse signal pathways.
Data
- Biased ligands
- 132 Physiology-biased
- 132 Pathway-biased
- 8,616 Total datapoints
- Pathways
- 324 Pathway effects
- Pathway-preferring ligands
- 1,672 Ligands
- Reference ligands
- 94 For pathway-bias
- 783 For physiology-bias
Welcome
The Biased Signaling Atlas is a new community platform.Read the article, try it out and let us know what you think.
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.Publications
A community Biased Signaling Atlas.
Caroli J, Mamyrbekov A, Harpsøe K, Gardizi S, Dörries L, Ghosh E, Hauser AS, Kooistra AJ & Gloriam DE
Nature Chemical Biology, 2023