Biased ligands
Biased ligands, receptor pathways coverage & bias rank orders.
Pathway effects
Pathway effects and therapeutic relevance.
Reference ligands
Reference ligands for pathway-/physiology-bias.
Bias calculation spreadsheet
Swifty calculate bias factors.
Data deposition
Deposit biased ligands & pathway effects.
Published!
The main article A community Biased signaling Atlas
has been published on Nature Chemical Biology.
We invite you all to read the article to have a deeper insight of this new resource.
Biased Signaling Atlas
Biased signaling entails hormones, probes, or drugs binding the same GPCR but engaging different intracellular
signaling pathways leading to distinct functional outcomes. This may let drugs favor therapeutic over adverse signal pathways.
Data
- Biased ligands
- 103 Physiology-biased
- 103 Pathway-biased
- 8,319 Total datapoints
- Pathways
- 308 Pathway effects
- Pathway-preferring ligands
- 1,648 Ligands
- Reference ligands
- 91 For pathway-bias
- 792 For physiology-bias
Welcome
The Biased Signaling Atlas is a new community platform.Read the article, try it out and let us know what you think.