PDB
21CI
Resolution
3.3 Å
Released
June 3, 2026
Receptor
OX2
Class
A
Species
Homo sapiens
Ligand
Function
vornorexant
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
vornorexant C107 2.57x56 TM2 Van der Waals
vornorexant A110 2.60x59 TM2 Van der Waals
vornorexant T111 2.61x60 TM2 hydrophobic
vornorexant W120 23.50x50 ECL1 Van der Waals
vornorexant I130 3.28x28 TM3 hydrophobic
vornorexant P131 3.29x29 TM3 Van der Waals
vornorexant Q134 3.32x32 TM3 hydrophobic
vornorexant T135 3.33x33 TM3 Van der Waals
vornorexant V138 3.36x36 TM3 Van der Waals
vornorexant Q187 4.60x61 TM4 Van der Waals
vornorexant M191 4.64x65 TM4 Van der Waals
vornorexant E212 45.52x52 ECL2 Van der Waals
vornorexant H224 5.39x40 TM5 Van der Waals
vornorexant F227 5.42x43 TM5 hydrophobic
vornorexant Y317 6.48x48 TM6 Van der Waals
vornorexant I320 6.51x51 TM6 hydrophobic
vornorexant N324 6.55x55 TM6 polar (hydrogen bond)
vornorexant H350 7.39x38 TM7 Van der Waals
vornorexant Y354 7.43x42 TM7 Van der Waals

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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
Helix box plot — Download: PNG | SVG V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7

GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x56 2.57x56 C107
2x59 2.60x59 A110
2x60 2.61x60 T111
ECL1
23x50 23.50x50 W120
TM3
3x28 3.28x28 I130
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
4x65 4.64x65 M191
ECL2
45x52 45.52x52 E212
TM5
5x40 5.39x40 H224
5x43 5.42x43 F227
TM6
6x48 6.48x48 Y317
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350
7x42 7.43x42 Y354