PDB
24TI
Resolution
2.9 Å
Released
July 8, 2026
Receptor
GHRH
Class
B1
Species
Homo sapiens
Ligand
PCO371
Function
Allosteric agonist
Reference
10.1093/PROCEL/PWAG016

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Ligand Amino Acid Generic Number Segment Interaction Type
PCO371 R161 2.46x46 TM2 polar (charge-assisted hydrogen bond)
PCO371 H165 2.50x50 TM2 aromatic (face-to-face)
PCO371 H165 2.50x50 TM2 polar (hydrogen bond)
PCO371 L168 2.53x53 TM2 Van der Waals
PCO371 L220 3.47x47 TM3 Van der Waals
PCO371 E223 3.50x50 TM3 polar (charge-assisted hydrogen bond)
PCO371 L227 3.54x54 TM3 Van der Waals
PCO371 L332 6.43x43 TM6 polar (hydrogen bond with backbone)
PCO371 L332 6.43x43 TM6 Van der Waals
PCO371 F333 6.44x44 TM6 polar (hydrogen bond with backbone)
PCO371 F333 6.44x44 TM6 Van der Waals
PCO371 L334 6.45x45 TM6 polar (hydrogen bond with backbone)
PCO371 L334 6.45x45 TM6 Van der Waals
PCO371 I335 6.46x46 TM6 polar (hydrogen bond with backbone)
PCO371 I335 6.46x46 TM6 Van der Waals
PCO371 P336 6.47x47 TM6 hydrophobic
PCO371 P336 6.47x47 TM6 Van der Waals
PCO371 L337 6.48x48 TM6 polar (hydrogen bond with backbone)
PCO371 L337 6.48x48 TM6 Van der Waals
PCO371 F338 6.49x49 TM6 polar (hydrogen bond with backbone)
PCO371 F338 6.49x49 TM6 Van der Waals
PCO371 V372 7.53x53 TM7 Van der Waals
PCO371 L375 7.56x56 TM7 polar (hydrogen bond with backbone)
PCO371 L375 7.56x56 TM7 Van der Waals
PCO371 Y376 7.57x57 TM7 polar (hydrogen bond)
PCO371 Y376 7.57x57 TM7 polar (hydrogen bond with backbone)
PCO371 N380 8.47x47 H8 polar (hydrogen bond)
PCO371 N380 8.47x47 H8 polar (hydrogen bond)
PCO371 N380 8.47x47 H8 polar (hydrogen bond)

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ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
Helix box plot — Download: PNG | SVG F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7

GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM2
2x39 2.46x46 R161
2x43 2.50x50 H165
2x46 2.53x53 L168
TM3
3x43 3.47x47 L220
3x46 3.50x50 E223
3x50 3.54x54 L227
TM6
6x38 6.43x43 L332
6x39 6.44x44 F333
6x40 6.45x45 L334
6x41 6.46x46 I335
6x42 6.47x47 P336
6x43 6.48x48 L337
6x44 6.49x49 F338
TM7
7x49 7.53x53 V372
7x52 7.56x56 L375
7x53 7.57x57 Y376
H8
8x47 8.47x47 N380