PDB
27XK
Resolution
2.6 Å
Released
July 1, 2026
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Glucagon-like peptide 1(7-36)
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Glucagon-like peptide 1(7-36) L32 N-term polar (hydrogen bond with backbone)
Glucagon-like peptide 1(7-36) L32 N-term Van der Waals
Glucagon-like peptide 1(7-36) T35 N-term Van der Waals
Glucagon-like peptide 1(7-36) V36 N-term hydrophobic
Glucagon-like peptide 1(7-36) V36 N-term Van der Waals
Glucagon-like peptide 1(7-36) W39 N-term hydrophobic
Glucagon-like peptide 1(7-36) W39 N-term Van der Waals
Glucagon-like peptide 1(7-36) E68 N-term Van der Waals
Glucagon-like peptide 1(7-36) Y88 N-term hydrophobic
Glucagon-like peptide 1(7-36) Y88 N-term Van der Waals
Glucagon-like peptide 1(7-36) W91 N-term Van der Waals
Glucagon-like peptide 1(7-36) W91 N-term hydrophobic
Glucagon-like peptide 1(7-36) R121 N-term Van der Waals
Glucagon-like peptide 1(7-36) S136 N-term Van der Waals
Glucagon-like peptide 1(7-36) E138 1.33x33 TM1 Van der Waals
Glucagon-like peptide 1(7-36) L141 1.36x36 TM1 Van der Waals
Glucagon-like peptide 1(7-36) L141 1.36x36 TM1 hydrophobic
Glucagon-like peptide 1(7-36) Y148 1.43x43 TM1 Van der Waals
Glucagon-like peptide 1(7-36) Y148 1.43x43 TM1 hydrophobic
Glucagon-like peptide 1(7-36) Y152 1.47x47 TM1 polar (hydrogen bond)
Glucagon-like peptide 1(7-36) Y152 1.47x47 TM1 Van der Waals
Glucagon-like peptide 1(7-36) R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Glucagon-like peptide 1(7-36) L201 2.71x71 TM2 hydrophobic
Glucagon-like peptide 1(7-36) L201 2.71x71 TM2 Van der Waals
Glucagon-like peptide 1(7-36) Y205 2.75x75 TM2 polar (hydrogen bond)
Glucagon-like peptide 1(7-36) Y205 2.75x75 TM2 Van der Waals
Glucagon-like peptide 1(7-36) H212 ECL1 Van der Waals
Glucagon-like peptide 1(7-36) Q221 ECL1 Van der Waals
Glucagon-like peptide 1(7-36) F230 3.33x33 TM3 Van der Waals
Glucagon-like peptide 1(7-36) F230 3.33x33 TM3 hydrophobic
Glucagon-like peptide 1(7-36) Q234 3.37x37 TM3 Van der Waals
Glucagon-like peptide 1(7-36) Q234 3.37x37 TM3 polar (hydrogen bond)
Glucagon-like peptide 1(7-36) V237 3.40x40 TM3 hydrophobic
Glucagon-like peptide 1(7-36) V237 3.40x40 TM3 Van der Waals
Glucagon-like peptide 1(7-36) Y241 3.44x44 TM3 Van der Waals
Glucagon-like peptide 1(7-36) T298 45.52x52 ECL2 polar (hydrogen bond)
Glucagon-like peptide 1(7-36) T298 45.52x52 ECL2 Van der Waals
Glucagon-like peptide 1(7-36) R299 ECL2 Van der Waals
Glucagon-like peptide 1(7-36) N300 ECL2 Van der Waals
Glucagon-like peptide 1(7-36) N300 ECL2 polar (hydrogen bond with backbone)
Glucagon-like peptide 1(7-36) W306 5.36x37 TM5 Van der Waals
Glucagon-like peptide 1(7-36) W306 5.36x37 TM5 polar (hydrogen bond)
Glucagon-like peptide 1(7-36) R310 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Glucagon-like peptide 1(7-36) R380 ECL3 polar (charge-assisted hydrogen bond)
Glucagon-like peptide 1(7-36) E387 7.42x41 TM7 Van der Waals
Glucagon-like peptide 1(7-36) L388 7.43x42 TM7 Van der Waals
Glucagon-like peptide 1(7-36) L388 7.43x42 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x29 3.33x33 F230
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
TM7
7x37 7.42x41 E387
7x38 7.43x42 L388