PDB
2Z73
Resolution
2.5 Å
Released
May 13, 2008
Receptor
Rhodopsin
Class
A
Species
Todarodes pacificus
Ligand
all-trans-retinal
Function
Inverse agonist
Reference
10.1038/NATURE06925

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal F120 3.37x37 TM3 hydrophobic
all-trans-retinal F188 45.52x52 ECL2 hydrophobic
all-trans-retinal M204 5.42x43 TM5 hydrophobic
all-trans-retinal F205 5.43x44 TM5 hydrophobic
all-trans-retinal F209 5.47x47 TM5 hydrophobic
all-trans-retinal F270 6.44x44 TM6 hydrophobic
all-trans-retinal W274 6.48x48 TM6 hydrophobic
all-trans-retinal Y277 6.51x51 TM6 hydrophobic
all-trans-retinal A278 6.52x52 TM6 hydrophobic

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ICL1 K S L Q ICL1ECL1 K W I F ECL1ICL2 P M A A S K K M ICL2ECL2 G W G A Y T L E G V L C N C S F D Y I S R ECL2ICL3 R L N ICL3ECL3 P L E W V ECL3N-term M G R D L R D N E T W W Y N P S I V V H P H W R E F D Q V P N-termC-term P W V L T C C Q F D D K E T E D D K D A E T E I P A G E S S D A A P S A D A A Q M K E M M A M M Q K M Q Q Q Q A A Y P P Q G Y A P P P Q G Y P P Q G Y P P Q G Y P P Q G Y P P Q G Y P P P P Q G A P P Q G A P P A A P P Q G V D N Q A Y Q A C-term D A V Y Y S L G I F I G I C G I I G C G G N G I V I Y L F T K T T P A N M F I I N L A F S D F T F S L V N G F P L M T I S C F L K G F A A C K V Y G F I G G I F G F M S I M T M A M I S I D R Y N V I G R S H R R A F I M I I F V W L W S V L W A I G P I F D S T T R S N I L C M F I L G F F G P I L I I F F C Y F N I V M S V S N H E K E M A A M A K A K E L R K A Q A G A N A E M R L A K I S I V I V S Q F L L S W S P Y A V V A L L A Q F G T P Y A A Q L P V M F A K A S A I H N P M I Y S V S H P K I S Q F R E A T F
Helix box plot — Download: PNG | SVG G N G G C G I I G C I G I F I G L S Y Y 1 I N L A F S D F T F S L V N F G P L M T I 2 M A M T M I S M F G F I G G I F G Y V K 3 A F I M I I F V W L W S V L W A I G P I 4 Y C F F I I L I P G F F G L I F M C L I N 5 I V I V S Q F L L S W S P Y A V V A L L 6 M P N H I A S A K A F M V P L Q A A Y 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM3
3x37 3.37x37 F120
ECL2
45x52 45.52x52 F188
TM5
5x43 5.42x43 M204
5x44 5.43x44 F205
5x47 5.47x47 F209
TM6
6x44 6.44x44 F270
6x48 6.48x48 W274
6x51 6.51x51 Y277
6x52 6.52x52 A278