Structure information

D3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3PBL

SPECIES

Homo sapiens

RESOLUTION

2.890

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.1197410

PUBLICATION DATE

Nov. 3, 2010

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
eticlopride F106 3.28x28 TM3 hydrophobic
eticlopride D110 3.32x32 TM3 polar (charge-assisted hydrogen bond)
eticlopride V111 3.33x33 TM3 hydrophobic
eticlopride V111 3.33x33 TM3 Van der Waals
eticlopride C114 3.36x36 TM3 Van der Waals
eticlopride I183 45.52x52 ECL2 hydrophobic
eticlopride I183 45.52x52 ECL2 Van der Waals
eticlopride V189 5.39x40 TM5 Van der Waals
eticlopride S192 5.42x43 TM5 Van der Waals
eticlopride S193 5.43x44 TM5 Van der Waals
eticlopride W342 6.48x48 TM6 Van der Waals
eticlopride W342 6.48x48 TM6 hydrophobic
eticlopride F345 6.51x51 TM6 Van der Waals
eticlopride F345 6.51x51 TM6 aromatic (edge-to-face)
eticlopride F346 6.52x52 TM6 hydrophobic
eticlopride F346 6.52x52 TM6 Van der Waals
eticlopride H349 6.55x55 TM6 polar (hydrogen bond)
eticlopride H349 6.55x55 TM6 Van der Waals
eticlopride Y365 7.35x34 TM7 Van der Waals
eticlopride T369 7.39x38 TM7 Van der Waals
eticlopride Y373 7.43x42 TM7 Van der Waals
eticlopride Y373 7.43x42 TM7 hydrophobic

Ligands

eticlopride

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Residue Diagrams

G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
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ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM3
3x28 3.28x28 F106
3x32 3.32x32 D110
3x33 3.33x33 V111
3x36 3.36x36 C114
ECL2
45x52 45.52x52 I183
TM5
5x40 5.39x40 V189
5x43 5.42x43 S192
5x44 5.43x44 S193
TM6
6x48 6.48x48 W342
6x51 6.51x51 F345
6x52 6.52x52 F346
6x55 6.55x55 H349
TM7
7x34 7.35x34 Y365
7x38 7.39x38 T369
7x42 7.43x42 Y373