PDB
4DKL
Resolution
2.8 Å
Released
March 21, 2012
Receptor
μ
Class
A
Species
Mus musculus
Ligand
beta-funaltrexamine
Function
Antagonist
Reference
10.1038/NATURE10954

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Ligand Amino Acid Generic Number Segment Interaction Type
beta-funaltrexamine D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
beta-funaltrexamine Y148 3.33x33 TM3 Van der Waals
beta-funaltrexamine Y148 3.33x33 TM3 polar (hydrogen bond)
beta-funaltrexamine M151 3.36x36 TM3 Van der Waals
beta-funaltrexamine K233 5.39x40 TM5 polar (charge-assisted hydrogen bond)
beta-funaltrexamine V236 5.42x43 TM5 Van der Waals
beta-funaltrexamine W293 6.48x48 TM6 hydrophobic
beta-funaltrexamine W293 6.48x48 TM6 Van der Waals
beta-funaltrexamine I296 6.51x51 TM6 hydrophobic
beta-funaltrexamine I296 6.51x51 TM6 Van der Waals
beta-funaltrexamine H297 6.52x52 TM6 aromatic (face-to-edge)
beta-funaltrexamine V300 6.55x55 TM6 Van der Waals
beta-funaltrexamine V300 6.55x55 TM6 hydrophobic
beta-funaltrexamine K303 6.58x58 TM6 Van der Waals
beta-funaltrexamine W318 7.35x34 TM7 Van der Waals
beta-funaltrexamine I322 7.39x38 TM7 hydrophobic
beta-funaltrexamine I322 7.39x38 TM7 Van der Waals
beta-funaltrexamine Y326 7.43x42 TM7 hydrophobic
beta-funaltrexamine Y326 7.43x42 TM7 Van der Waals

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
TM5
5x40 5.39x40 K233
5x43 5.42x43 V236
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
6x58 6.58x58 K303
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322
7x42 7.43x42 Y326