PDB
5DHH
Resolution
3.0 Å
Released
Oct. 21, 2015
Receptor
NOP
Class
A
Species
Homo sapiens
Ligand
Function
SB 612111
Antagonist
Reference
10.1016/J.STR.2015.07.024

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Ligand Amino Acid Generic Number Segment Interaction Type
SB 612111 Q107 2.60x60 TM2 hydrophobic
SB 612111 D110 2.63x63 TM2 Van der Waals
SB 612111 I111 2.64x64 TM2 hydrophobic
SB 612111 W116 23.50x50 ECL1 hydrophobic
SB 612111 I127 3.29x29 TM3 Van der Waals
SB 612111 D130 3.32x32 TM3 polar (hydrogen bond)
SB 612111 D130 3.32x32 TM3 polar (charge-charge)
SB 612111 Y131 3.33x33 TM3 hydrophobic
SB 612111 Y131 3.33x33 TM3 aromatic (edge-to-face)
SB 612111 M134 3.36x36 TM3 hydrophobic
SB 612111 C200 45.50x50 ECL2 hydrophobic
SB 612111 I219 5.42x43 TM5 hydrophobic
SB 612111 S223 5.46x461 TM5 Van der Waals
SB 612111 W276 6.48x48 TM6 Van der Waals
SB 612111 V279 6.51x51 TM6 hydrophobic
SB 612111 Q280 6.52x52 TM6 Van der Waals
SB 612111 V283 6.55x55 TM6 hydrophobic
SB 612111 R302 7.36x35 TM7 Van der Waals
SB 612111 T305 7.39x38 TM7 Van der Waals
SB 612111 Y309 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 F W P F ECL1ICL2 P I R A L D V R ICL2ECL2 S A Q V E D E E I E C L V E I P T ECL2ICL3 R L L S G ICL3ECL3 V Q P S ECL3N-term M E P L F P A P F W E V I Y G S H L Q G N L S L L S P N H S L L P P H L L L N A S H G A F L P N-termC-term A S A L R R D V Q V S D R V R S I A K D V A L A C K T S E T V P R P A C-term L G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H T S S K A Q A V N V A I W A L A S V V G V P V A I M G P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F R K F K A C F C C
Helix box plot — Download: PNG | SVG C N G L L G G V C V A L Y L G V I T V K 1 F N L A L A D T L V L L T L P F Q G T D 2 A T L T F T S T F M N Y Y D I A I V T K 3 A Q A V N V A I W A L A S V V G V P V A 4 Y C V S I V L V P V I F S F L F I C I A F 5 L V V V A V F V G C W T P V Q V F V L A 6 I P N L C S N V Y G L A T C F R L I A 7

GPCRdb(A)
GPCRdb(A)
NOP receptor
TM2
2x60 2.60x60 Q107
2x63 2.63x63 D110
2x64 2.64x64 I111
ECL1
23x50 23.50x50 W116
TM3
3x29 3.29x29 I127
3x32 3.32x32 D130
3x33 3.33x33 Y131
3x36 3.36x36 M134
ECL2
45x50 45.50x50 C200
TM5
5x43 5.42x43 I219
5x461 5.46x461 S223
TM6
6x48 6.48x48 W276
6x51 6.51x51 V279
6x52 6.52x52 Q280
6x55 6.55x55 V283
TM7
7x35 7.36x35 R302
7x38 7.39x38 T305
7x42 7.43x42 Y309