Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5TGZ

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2016.10.004

PUBLICATION DATE

Nov. 2, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM6538 F102 N-term hydrophobic
AM6538 M103 N-term hydrophobic
AM6538 F170 2.57x57 TM2 hydrophobic
AM6538 F174 2.61x61 TM2 hydrophobic
AM6538 L193 3.29x29 TM3 hydrophobic
AM6538 V196 3.32x32 TM3 hydrophobic
AM6538 F268 ECL2 hydrophobic
AM6538 W356 6.48x48 TM6 hydrophobic
AM6538 L359 6.51x51 TM6 hydrophobic
AM6538 C386 7.42x41 TM7 hydrophobic
AM6538 L387 7.43x42 TM7 hydrophobic

Ligands

AM6538

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
TM3
3x29 3.29x29 L193
3x32 3.32x32 V196
TM6
6x48 6.48x48 W356
6x51 6.51x51 L359
TM7
7x41 7.42x41 C386
7x42 7.43x42 L387