Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5U09

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE20613

PUBLICATION DATE

Dec. 7, 2016

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
taranabant F102 N-term hydrophobic
taranabant M103 N-term hydrophobic
taranabant I105 N-term hydrophobic
taranabant F108 N-term hydrophobic
taranabant S123 1.39x39 TM1 polar (hydrogen bond)
taranabant G166 2.53x53 TM2 Van der Waals
taranabant F170 2.57x57 TM2 Van der Waals
taranabant F170 2.57x57 TM2 aromatic (edge-to-face)
taranabant L193 3.29x29 TM3 Van der Waals
taranabant V196 3.32x32 TM3 hydrophobic
taranabant V196 3.32x32 TM3 Van der Waals
taranabant F268 ECL2 hydrophobic
taranabant F268 ECL2 Van der Waals
taranabant W279 5.43x43 TM5 hydrophobic
taranabant W356 6.48x48 TM6 hydrophobic
taranabant W356 6.48x48 TM6 Van der Waals
taranabant L359 6.51x51 TM6 hydrophobic
taranabant F379 7.35x34 TM7 Van der Waals
taranabant F379 7.35x34 TM7 hydrophobic
taranabant A380 7.36x35 TM7 hydrophobic
taranabant A380 7.36x35 TM7 Van der Waals
taranabant S383 7.39x38 TM7 polar (hydrogen bond)
taranabant S383 7.39x38 TM7 polar (hydrogen bond)
taranabant M384 7.40x39 TM7 polar (hydrogen bond)
taranabant C386 7.42x41 TM7 polar (hydrogen bond with backbone)
taranabant C386 7.42x41 TM7 Van der Waals
taranabant L387 7.43x42 TM7 Van der Waals

Ligands

taranabant

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
Download: PNG | SVG
ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM1
1x39 1.39x39 S123
TM2
2x53 2.53x53 G166
2x57 2.57x57 F170
TM3
3x29 3.29x29 L193
3x32 3.32x32 V196
TM5
5x43 5.43x43 W279
TM6
6x48 6.48x48 W356
6x51 6.51x51 L359
TM7
7x34 7.35x34 F379
7x35 7.36x35 A380
7x38 7.39x38 S383
7x39 7.40x39 M384
7x41 7.42x41 C386
7x42 7.43x42 L387