Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5X93

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

REFERENCE

10.1038/NSMB.3450

PUBLICATION DATE

Aug. 16, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
K-8794 H150 2.53x53 TM2 Van der Waals
K-8794 H150 2.53x53 TM2 polar (hydrogen bond)
K-8794 H150 2.53x53 TM2 aromatic (edge-to-face)
K-8794 A154 2.57x56 TM2 Van der Waals
K-8794 N158 2.61x60 TM2 Van der Waals
K-8794 W167 23.50x50 ECL1 hydrophobic
K-8794 V177 3.28x28 TM3 Van der Waals
K-8794 V177 3.28x28 TM3 hydrophobic
K-8794 P178 3.29x29 TM3 Van der Waals
K-8794 P178 3.29x29 TM3 hydrophobic
K-8794 Q181 3.32x32 TM3 Van der Waals
K-8794 Q181 3.32x32 TM3 polar (hydrogen bond)
K-8794 K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
K-8794 V185 3.36x36 TM3 hydrophobic
K-8794 V185 3.36x36 TM3 Van der Waals
K-8794 F240 4.64x65 TM4 aromatic (edge-to-face)
K-8794 F240 4.64x65 TM4 Van der Waals
K-8794 C255 45.50x50 ECL2 Van der Waals
K-8794 K273 5.38x39 TM5 polar (charge-assisted hydrogen bond)
K-8794 L277 5.42x43 TM5 hydrophobic
K-8794 L277 5.42x43 TM5 Van der Waals
K-8794 Y281 5.46x461 TM5 hydrophobic
K-8794 Y281 5.46x461 TM5 Van der Waals
K-8794 W336 6.48x48 TM6 hydrophobic
K-8794 W336 6.48x48 TM6 Van der Waals
K-8794 L339 6.51x51 TM6 hydrophobic
K-8794 L339 6.51x51 TM6 Van der Waals
K-8794 H340 6.52x52 TM6 Van der Waals
K-8794 H340 6.52x52 TM6 aromatic (face-to-edge)
K-8794 R343 6.55x55 TM6 Van der Waals
K-8794 I372 7.39x38 TM7 hydrophobic
K-8794 I372 7.39x38 TM7 Van der Waals
K-8794 A375 7.42x41 TM7 hydrophobic
K-8794 A375 7.42x41 TM7 Van der Waals
K-8794 S376 7.43x42 TM7 Van der Waals

Ligands

K-8794

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x53 2.53x53 H150
2x56 2.57x56 D154
2x60 2.61x60 N158
ECL1
23x50 23.50x50 W167
TM3
3x28 3.28x28 V177
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
TM4
4x65 4.64x65 F240
ECL2
45x50 45.50x50 C255
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
5x461 5.46x461 Y281
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x52 6.52x52 H340
6x55 6.55x55 R343
TM7
7x38 7.39x38 I372
7x41 7.42x41 A375
7x42 7.43x42 S376