PDB
5ZKP
Resolution
2.8 Å
Released
June 20, 2018
Receptor
PAF
Class
A
Species
Homo sapiens
Ligand
Function
foropafant
Antagonist
Reference
10.1038/S41594-018-0068-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
foropafant F18 1.35x35 TM1 Van der Waals
foropafant Y22 1.39x39 TM1 hydrophobic
foropafant W73 2.60x60 TM2 aromatic (face-to-face)
foropafant W73 2.60x60 TM2 hydrophobic
foropafant Y77 2.64x64 TM2 polar (hydrogen bond)
foropafant G94 3.29x29 TM3 Van der Waals
foropafant F97 3.32x32 TM3 aromatic (edge-to-face)
foropafant F97 3.32x32 TM3 hydrophobic
foropafant F98 3.33x33 TM3 aromatic (edge-to-face)
foropafant F98 3.33x33 TM3 hydrophobic
foropafant T101 3.36x36 TM3 hydrophobic
foropafant Y102 3.37x37 TM3 hydrophobic
foropafant F152 4.60x60 TM4 hydrophobic
foropafant F174 45.51x51 ECL2 hydrophobic
foropafant Y177 ECL2 Van der Waals
foropafant H188 5.40x40 TM5 aromatic (edge-to-face)
foropafant I191 5.43x43 TM5 hydrophobic
foropafant V192 5.44x44 TM5 Van der Waals
foropafant H248 6.51x51 TM6 Van der Waals
foropafant Q252 6.55x55 TM6 hydrophobic
foropafant W255 6.58x58 TM6 Van der Waals
foropafant H275 7.35x34 TM7 Van der Waals
foropafant L279 7.39x38 TM7 Van der Waals
foropafant L282 7.42x41 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P C K K ICL1ECL1 G N W I L ECL1ICL2 P I K T A Q A N ICL2ECL2 D S T N T V P D S A G S G N V T R C F E H Y E K G ECL2ICL3 P V Q Q ICL3ECL3 F Q ECL3N-term M E P H D S S H M N-termC-term S R K C S R A T T D T V T E V V V P F N Q I P G N S L K N C-term D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R T R K R G I S L S L V I W V A I V G A A S Y F L I L S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K K F Y H L T E S M R S
Helix box plot — Download: PNG | SVG G N A I V G L V F I I S Y V I P F L T Y 1 V N L T M A D M L F L I T L P L W I V Y 2 V G L F A V S C Y T N I F F L C G A V N 3 G I S L S L V I W V A I V G A A S Y F L 4 N C F L I I L F V L F F S F V I F I H I 5 V C T V L A V F I I C F V P H H V V Q L P 6 V P D L V C N T S L L C L T V Q H A D 7

GPCRdb(A)
GPCRdb(A)
PAF receptor
TM1
1x35 1.35x35 F18
1x39 1.39x39 Y22
TM2
2x60 2.60x60 W73
2x64 2.64x64 Y77
TM3
3x29 3.29x29 G94
3x32 3.32x32 F97
3x33 3.33x33 F98
3x36 3.36x36 T101
3x37 3.37x37 Y102
TM4
4x60 4.60x60 F152
ECL2
45x51 45.51x51 F174
TM5
5x40 5.40x40 H188
5x43 5.43x43 I191
5x44 5.44x44 V192
TM6
6x51 6.51x51 H248
6x55 6.55x55 Q252
6x58 6.58x58 W255
TM7
7x34 7.35x34 H275
7x38 7.39x38 L279
7x41 7.42x41 L282