PDB
6AK3
Resolution
2.9 Å
Released
Dec. 5, 2018
Receptor
EP3
Class
A
Species
Homo sapiens
Ligand
PGE2
Function
Agonist
Reference
10.1038/S41589-018-0171-8

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Ligand Amino Acid Generic Number Segment Interaction Type
PGE2 M58 1.42x42 TM1 hydrophobic
PGE2 V110 2.61x61 TM2 hydrophobic
PGE2 Y114 2.65x65 TM2 Van der Waals
PGE2 Y114 2.65x65 TM2 polar (hydrogen bond)
PGE2 M137 3.32x32 TM3 Van der Waals
PGE2 M137 3.32x32 TM3 hydrophobic
PGE2 G141 3.36x36 TM3 Van der Waals
PGE2 T206 ECL2 Van der Waals
PGE2 T206 ECL2 polar (hydrogen bond)
PGE2 W207 ECL2 Van der Waals
PGE2 W207 ECL2 hydrophobic
PGE2 W295 6.48x48 TM6 hydrophobic
PGE2 L329 7.36x35 TM7 hydrophobic
PGE2 L329 7.36x35 TM7 Van der Waals
PGE2 V332 7.39x38 TM7 hydrophobic
PGE2 V332 7.39x38 TM7 Van der Waals
PGE2 R333 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE2 S336 7.43x42 TM7 Van der Waals
PGE2 Q339 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
Helix box plot — Download: PNG | SVG A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7

GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM1
1x42 1.42x42 M58
TM2
2x61 2.61x61 V110
2x65 2.65x65 Y114
TM3
3x32 3.32x32 M137
3x36 3.36x36 G141
TM6
6x48 6.48x48 W295
TM7
7x35 7.36x35 L329
7x38 7.39x38 V332
7x39 7.40x39 R333
7x42 7.43x42 S336
7x46 7.46x46 Q339