PDB
6CM4
Resolution
2.9 Å
Released
March 14, 2018
Receptor
D2
Class
A
Species
Homo sapiens
Ligand
Function
risperidone
Inverse agonist
Reference
10.1038/NATURE25758

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Ligand Amino Acid Generic Number Segment Interaction Type
risperidone L94 2.64x63 TM2 Van der Waals
risperidone W100 23.50x50 ECL1 aromatic (edge-to-face)
risperidone W100 23.50x50 ECL1 hydrophobic
risperidone F110 3.28x28 TM3 hydrophobic
risperidone D114 3.32x32 TM3 polar (charge-charge)
risperidone D114 3.32x32 TM3 polar (hydrogen bond)
risperidone V115 3.33x33 TM3 hydrophobic
risperidone C118 3.36x36 TM3 hydrophobic
risperidone T119 3.37x37 TM3 Van der Waals
risperidone A122 3.40x40 TM3 Van der Waals
risperidone S193 5.42x43 TM5 Van der Waals
risperidone S197 5.46x461 TM5 Van der Waals
risperidone F198 5.47x47 TM5 aromatic (edge-to-face)
risperidone F382 6.44x44 TM6 Van der Waals
risperidone W386 6.48x48 TM6 hydrophobic
risperidone W386 6.48x48 TM6 aromatic (edge-to-face)
risperidone F389 6.51x51 TM6 Van der Waals
risperidone F390 6.52x52 TM6 hydrophobic
risperidone F390 6.52x52 TM6 aromatic (edge-to-face)
risperidone Y408 7.35x34 TM7 hydrophobic
risperidone S409 7.36x35 TM7 Van der Waals
risperidone T412 7.39x38 TM7 hydrophobic
risperidone Y416 7.43x42 TM7 Van der Waals

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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
Helix box plot — Download: PNG | SVG V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7

GPCRdb(A)
GPCRdb(A)
D2 receptor
TM2
2x63 2.64x63 L94
ECL1
23x50 23.50x50 W100
TM3
3x28 3.28x28 F110
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
3x37 3.37x37 T119
3x40 3.40x40 I122
TM5
5x43 5.42x43 S193
5x461 5.46x461 S197
5x47 5.47x47 F198
TM6
6x44 6.44x44 F382
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x34 7.35x34 Y408
7x35 7.36x35 S409
7x38 7.39x38 T412
7x42 7.43x42 Y416