PDB
6D27
Resolution
2.7 Å
Released
Oct. 3, 2018
Receptor
DP2
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL179036
Antagonist
Reference
10.1016/J.MOLCEL.2018.08.009

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL179036 M17 N-term hydrophobic
CHEMBL179036 F87 2.60x60 TM2 Van der Waals
CHEMBL179036 F90 2.63x63 TM2 Van der Waals
CHEMBL179036 H107 3.28x28 TM3 Van der Waals
CHEMBL179036 S108 3.29x29 TM3 Van der Waals
CHEMBL179036 F111 3.32x32 TM3 hydrophobic
CHEMBL179036 F111 3.32x32 TM3 aromatic (edge-to-face)
CHEMBL179036 F112 3.33x33 TM3 Van der Waals
CHEMBL179036 R170 4.64x65 TM4 aromatic (pi-cation)
CHEMBL179036 R170 4.64x65 TM4 polar (charge-charge)
CHEMBL179036 Y183 45.51x51 ECL2 aromatic (edge-to-face)
CHEMBL179036 Y183 45.51x51 ECL2 hydrophobic
CHEMBL179036 Y184 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL179036 K210 5.42x43 TM5 polar (charge-charge)
CHEMBL179036 Y2262 6.51x51 TM6 polar (hydrogen bond)
CHEMBL179036 V2282 7.31x30 TM7 Van der Waals
CHEMBL179036 W2283 7.32x31 TM7 Van der Waals
CHEMBL179036 L2286 7.35x34 TM7 Van der Waals
CHEMBL179036 P2287 7.36x35 TM7 hydrophobic
CHEMBL179036 T2290 7.39x38 TM7 Van der Waals
CHEMBL179036 F2294 7.43x42 TM7 aromatic (edge-to-face)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I S R L D G R I M C Y Y N V L L L N P G P ECL2ICL3 G R R R ICL3ECL3 H A N P G ECL3N-term M S A N A T L K P L C P I L E Q M S R L Q S H S N T S I R Y I N-termC-term V L V D D S E L G G A G S S R R R R T S S T A R S A S P L A L C S R P E E P R G P A R L L G W L L G S C A A S P Q T G P L N R A L S S T S S C-term D H A A V L L H G L A S L L G L V E N G V I L F V V G C R T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D L R R V L E M L R K S L R T S
Helix box plot — Download: PNG | SVG G N E V L G L L S A L G H L L V A A H D 1 L H L A L S D L L A S A S L P F F T Y F 2 A S L L F G S A F M N L F F I S S H L K 3 A H K V C L V L W A L A V L N T V P Y 4 H S S A I I A L P V L F A L L F K S V A L 5 A A V V A A F A L C W G P Y H V F S L L 6 V P N A V S N F F A L S T V F P L G R 7

GPCRdb(A)
GPCRdb(A)
DP2 receptor
TM2
2x60 2.60x60 F87
2x63 2.63x63 F90
TM3
3x28 3.28x28 H107
3x29 3.29x29 S108
3x32 3.32x32 F111
3x33 3.33x33 F112
TM4
4x65 4.64x65 R170
ECL2
45x51 45.51x51 Y183
45x52 45.52x52 Y184
TM5
5x43 5.42x43 K210
TM6
6x51 6.51x51 Y262
TM7
7x30 7.31x30 V282
7x31 7.32x31 W283
7x34 7.35x34 L286
7x35 7.36x35 P287
7x38 7.39x38 T290
7x42 7.43x42 F294