PDB
6D27
Resolution
2.7 Å
Released
Oct. 3, 2018
Receptor
DP2
Class
A
Species
Homo sapiens
Ligand
CHEMBL179036
Function
Antagonist
Reference
10.1016/J.MOLCEL.2018.08.009

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL179036 M17 N-term hydrophobic
CHEMBL179036 F111 3.32x32 TM3 aromatic (face-to-edge)
CHEMBL179036 R170 4.64x65 TM4 polar (charge-assisted hydrogen bond)
CHEMBL179036 Y183 45.51x51 ECL2 aromatic (face-to-edge)
CHEMBL179036 Y183 45.51x51 ECL2 Van der Waals
CHEMBL179036 Y184 45.52x52 ECL2 Van der Waals
CHEMBL179036 Y184 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL179036 Y2262 6.51x51 TM6 polar (hydrogen bond)
CHEMBL179036 Y2262 6.51x51 TM6 Van der Waals
CHEMBL179036 W2283 7.32x31 TM7 Van der Waals
CHEMBL179036 L2286 7.35x34 TM7 Van der Waals
CHEMBL179036 T2290 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I S R L D G R I M C Y Y N V L L L N P G P ECL2ICL3 G R R R ICL3ECL3 H A N P G ECL3N-term M S A N A T L K P L C P I L E Q M S R L Q S H S N T S I R Y I N-termC-term V L V D D S E L G G A G S S R R R R T S S T A R S A S P L A L C S R P E E P R G P A R L L G W L L G S C A A S P Q T G P L N R A L S S T S S C-term D H A A V L L H G L A S L L G L V E N G V I L F V V G C R T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D L R R V L E M L R K S L R T S
Helix box plot — Download: PNG | SVG G N E V L G L L S A L G H L L V A A H D 1 L H L A L S D L L A S A S L P F F T Y F 2 A S L L F G S A F M N L F F I S S H L K 3 A H K V C L V L W A L A V L N T V P Y 4 H S S A I I A L P V L F A L L F K S V A L 5 A A V V A A F A L C W G P Y H V F S L L 6 V P N A V S N F F A L S T V F P L G R 7

GPCRdb(A)
GPCRdb(A)
DP2 receptor
TM3
3x32 3.32x32 F111
TM4
4x65 4.64x65 R170
ECL2
45x51 45.51x51 Y183
45x52 45.52x52 Y184
TM6
6x51 6.51x51 Y262
TM7
7x31 7.32x31 W283
7x34 7.35x34 L286
7x38 7.39x38 T290