PDB
6FK6
Resolution
2.4 Å
Released
April 4, 2018
Receptor
Rhodopsin
Class
A
Species
Bos taurus
Ligand
Function
S-RS1
Agonist
Reference
10.1073/PNAS.1718084115

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Ligand Amino Acid Generic Number Segment Interaction Type
S-RS1 T118 3.33x33 TM3 hydrophobic
S-RS1 G121 3.36x36 TM3 Van der Waals
S-RS1 E122 3.37x37 TM3 hydrophobic
S-RS1 L125 3.40x40 TM3 hydrophobic
S-RS1 C167 4.56x56 TM4 Van der Waals
S-RS1 Y191 ECL2 Van der Waals
S-RS1 V204 5.39x40 TM5 hydrophobic
S-RS1 M207 5.42x43 TM5 Van der Waals
S-RS1 F208 5.43x44 TM5 hydrophobic
S-RS1 H211 5.46x461 TM5 Van der Waals
S-RS1 F212 5.47x47 TM5 aromatic (edge-to-face)
S-RS1 F212 5.47x47 TM5 hydrophobic
S-RS1 C264 6.47x47 TM6 Van der Waals
S-RS1 W265 6.48x48 TM6 hydrophobic
S-RS1 Y268 6.51x51 TM6 hydrophobic
S-RS1 Y268 6.51x51 TM6 aromatic (edge-to-face)
S-RS1 A272 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P M S N F R F ICL2ECL2 W S R Y I P E G M Q C S C G I D Y Y T P H E E T ECL2ICL3 Q E ICL3ECL3 Q G S D F ECL3N-term M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A N-termC-term C G K N P L G D D E A S T T V S K T E T S Q V A P A C-term E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K G E N H A I M G V A F T W V M A L A C A A P P L V G N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q M V T F R N C T L C
Helix box plot — Download: PNG | SVG F N I P F G L M I L L F M Y A A L M S F 1 L N L A V A D L F M V G F G F T T T L Y T 2 V V L S W L A I E G G L T A F F G E L N 3 A I M G V A F T W V M A L A C A A P P L 4 Y C F F I V I L P I I F H V V F M Y I V F 5 I I M V I A F L I C W L P Y A G V A F Y 6 V P N Y V A S T K A F F A P I T M F I 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM3
3x33 3.33x33 T118
3x36 3.36x36 G121
3x37 3.37x37 E122
3x40 3.40x40 L125
TM4
4x56 4.56x56 C167
TM5
5x40 5.39x40 V204
5x43 5.42x43 M207
5x44 5.43x44 F208
5x461 5.46x461 H211
5x47 5.47x47 F212
TM6
6x47 6.47x47 C264
6x48 6.48x48 W265
6x51 6.51x51 Y268
6x55 6.55x55 A272