PDB
6KUW
Resolution
2.8 Å
Released
Dec. 4, 2019
Receptor
α2C
Class
A
Species
Homo sapiens
Ligand
E33
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
E33 D131 3.32x32 TM3 polar (charge-assisted hydrogen bond)
E33 V132 3.33x33 TM3 Van der Waals
E33 V132 3.33x33 TM3 hydrophobic
E33 C135 3.36x36 TM3 Van der Waals
E33 C135 3.36x36 TM3 hydrophobic
E33 L204 45.52x52 ECL2 hydrophobic
E33 L204 45.52x52 ECL2 Van der Waals
E33 S214 5.42x43 TM5 Van der Waals
E33 S218 5.46x461 TM5 Van der Waals
E33 W395 6.48x48 TM6 hydrophobic
E33 W395 6.48x48 TM6 Van der Waals
E33 F398 6.51x51 TM6 hydrophobic
E33 F398 6.51x51 TM6 Van der Waals
E33 F399 6.52x52 TM6 hydrophobic
E33 F399 6.52x52 TM6 Van der Waals
E33 Y402 6.55x55 TM6 hydrophobic
E33 Y402 6.55x55 TM6 Van der Waals
E33 F423 7.39x38 TM7 Van der Waals
E33 F423 7.39x38 TM7 hydrophobic
E33 Y427 7.43x42 TM7 Van der Waals

E33

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ICL1 R A L R ICL1ECL1 Y W Y F ECL1ICL2 A V E Y N L K R ICL2ECL2 S L Y R Q P D G A A Y P Q C G L N D ECL2ICL3 R A P V G P D G A S P T T E N G L G A A A G A G E N G H C A P P P A D V E P D E S S A A A E R R R R R G A L R R G G R R R A G A E G G A G G A D G Q G A G P G A A E S G A L T A S R S P G P G G R L S R A S S R S V E F F L S R R R R A R S S V C R R ICL3ECL3 E A C Q V ECL3N-term M A S P A L A A A L A V A A A A G P N A S G A G E R G S G G V A N A S G A S W G P P R G Q Y N-termC-term R R R R R G F R Q C-term S A G A V A G L A A V V G F L I V F T V V G N V L V V I A V L T S A P Q N L F L V S L A S A D I L V A T L V M P F S L A N E L M A G Q V W C G V Y L A L D V L F C T S S I V H L C A I S L D R Y W S V T Q T P R R V K A T I V A V W L I S A V I S F P P L V E T W Y I L S S C I G S F F A P C L I M G L V Y A R I Y R V A K L R T R T L S E K K V A Q A R E K R F T F V L A V V M G V F V L C W F P F F F S Y S L Y G I C R P G P L F K F F F W I G Y C N S S L N P V I Y T V F N Q D F K H F R R S I L F
Helix box plot — Download: PNG | SVG V N G V V T F V I L F G V V A A L G A V 1 V S L A S A D I L V A L T V M P F S L A N 2 A C L H V I S S T C F L V D L A L Y V G 3 V K A T I V A V W L I S A V I S F P P L 4 Y V L G M I L C P A F F S G I C S S L I Y 5 A V V M G V F V L C W F P F F F S Y S L 6 V P N L S S N C Y G I W F F F K F L P 7

GPCRdb(A)
GPCRdb(A)
α2C-adrenoceptor
TM3
3x32 3.32x32 D131
3x33 3.33x33 V132
3x36 3.36x36 C135
ECL2
45x52 45.52x52 L204
TM5
5x43 5.42x43 S214
5x461 5.46x461 S218
TM6
6x48 6.48x48 W395
6x51 6.51x51 F398
6x52 6.52x52 F399
6x55 6.55x55 Y402
TM7
7x38 7.39x38 F423
7x42 7.43x42 Y427