PDB
6M9T
Resolution
2.5 Å
Released
Dec. 5, 2018
Receptor
EP3
Class
A
Species
Homo sapiens
Ligand
Misoprostol acid
Function
Agonist
Reference
10.1038/S41589-018-0160-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
Misoprostol acid Y114 2.65x65 TM2 polar (hydrogen bond)
Misoprostol acid Y114 2.65x65 TM2 Van der Waals
Misoprostol acid M137 3.32x32 TM3 hydrophobic
Misoprostol acid M137 3.32x32 TM3 Van der Waals
Misoprostol acid F140 3.35x35 TM3 hydrophobic
Misoprostol acid F140 3.35x35 TM3 Van der Waals
Misoprostol acid T206 ECL2 polar (hydrogen bond)
Misoprostol acid T206 ECL2 Van der Waals
Misoprostol acid W207 ECL2 hydrophobic
Misoprostol acid W207 ECL2 Van der Waals
Misoprostol acid F209 45.51x51 ECL2 Van der Waals
Misoprostol acid W295 6.48x48 TM6 hydrophobic
Misoprostol acid W295 6.48x48 TM6 Van der Waals
Misoprostol acid L329 7.36x35 TM7 hydrophobic
Misoprostol acid L329 7.36x35 TM7 Van der Waals
Misoprostol acid V332 7.39x38 TM7 hydrophobic
Misoprostol acid V332 7.39x38 TM7 Van der Waals
Misoprostol acid R333 7.40x39 TM7 polar (charge-assisted hydrogen bond)
Misoprostol acid S336 7.43x42 TM7 Van der Waals
Misoprostol acid Q339 7.46x46 TM7 polar (hydrogen bond)
Misoprostol acid Q339 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
Helix box plot — Download: PNG | SVG A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7

GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM2
2x65 2.65x65 Y114
TM3
3x32 3.32x32 M137
3x35 3.35x35 F140
ECL2
45x51 45.51x51 F209
TM6
6x48 6.48x48 W295
TM7
7x35 7.36x35 L329
7x38 7.39x38 V332
7x39 7.40x39 R333
7x42 7.43x42 S336
7x46 7.46x46 Q339