PDB
6ME9
Resolution
3.3 Å
Released
April 24, 2019
Receptor
MT2
Class
A
Species
Homo sapiens
Ligand
ramelteon
Function
Agonist
Reference
10.1038/S41586-019-1144-0

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon M120 3.32x32 TM3 hydrophobic
ramelteon I125 3.37x37 TM3 hydrophobic
ramelteon N175 4.60x61 TM4 polar (hydrogen bond)
ramelteon N175 4.60x61 TM4 Van der Waals
ramelteon L181 ECL2 Van der Waals
ramelteon F192 45.52x52 ECL2 Van der Waals
ramelteon F192 45.52x52 ECL2 aromatic (face-to-face)
ramelteon Q194 ECL2 polar (hydrogen bond)
ramelteon Q194 ECL2 Van der Waals
ramelteon Y200 5.38x39 TM5 Van der Waals
ramelteon V204 5.42x43 TM5 Van der Waals
ramelteon V204 5.42x43 TM5 hydrophobic
ramelteon L267 6.51x51 TM6 hydrophobic
ramelteon L267 6.51x51 TM6 Van der Waals
ramelteon N268 6.52x52 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
Helix box plot — Download: PNG | SVG L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7

GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x32 3.32x32 M120
3x37 3.37x37 I125
TM4
4x61 4.60x61 N175
ECL2
45x52 45.52x52 F192
TM5
5x39 5.38x39 Y200
5x43 5.42x43 V204
TM6
6x51 6.51x51 L267
6x52 6.52x52 N268