PDB
6OMM
Resolution
3.2 Å
Released
Feb. 26, 2020
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
WKYMVM
Function
Agonist
Reference
10.1038/S41467-020-14728-9

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Ligand Amino Acid Generic Number Segment Interaction Type
WKYMVM E89 ECL1 polar (charge-assisted hydrogen bond)
WKYMVM H102 3.29x29 TM3 Van der Waals
WKYMVM D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
WKYMVM L109 3.36x36 TM3 Van der Waals
WKYMVM F110 3.37x37 TM3 hydrophobic
WKYMVM F110 3.37x37 TM3 Van der Waals
WKYMVM L164 4.64x65 TM4 Van der Waals
WKYMVM L164 4.64x65 TM4 hydrophobic
WKYMVM T177 45.51x51 ECL2 Van der Waals
WKYMVM F178 45.52x52 ECL2 aromatic (face-to-edge)
WKYMVM F178 45.52x52 ECL2 Van der Waals
WKYMVM L198 5.35x36 TM5 hydrophobic
WKYMVM L198 5.35x36 TM5 Van der Waals
WKYMVM R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
WKYMVM R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
WKYMVM A261 6.55x55 TM6 Van der Waals
WKYMVM M271 ECL3 Van der Waals
WKYMVM D281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
WKYMVM V284 7.35x34 TM7 hydrophobic
WKYMVM V284 7.35x34 TM7 Van der Waals
WKYMVM N285 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x29 3.29x29 H102
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
TM4
4x65 4.64x65 L164
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x55 6.55x55 A261
TM7
7x31 7.32x31 D281
7x34 7.35x34 V284
7x35 7.36x35 N285