PDB
6PT0
Resolution
3.2 Å
Released
Feb. 12, 2020
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
WIN55212-2
Function
Agonist
Reference
10.1016/J.CELL.2020.01.007

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Ligand Amino Acid Generic Number Segment Interaction Type
WIN55212-2 F87 2.57x57 TM2 hydrophobic
WIN55212-2 F91 2.61x61 TM2 hydrophobic
WIN55212-2 F94 2.64x64 TM2 aromatic (face-to-edge)
WIN55212-2 I110 3.29x29 TM3 hydrophobic
WIN55212-2 F183 ECL2 hydrophobic
WIN55212-2 P184 ECL2 hydrophobic
WIN55212-2 I186 ECL2 hydrophobic
WIN55212-2 Y190 5.39x39 TM5 hydrophobic
WIN55212-2 L191 5.40x40 TM5 hydrophobic
WIN55212-2 W194 5.43x43 TM5 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
TM5
5x39 5.39x39 Y190
5x40 5.40x40 L191
5x43 5.43x43 W194