PDB
6UUS
Resolution
2.4 Å
Released
April 1, 2020
Receptor
calcitonin-like
Class
B1
Species
Homo sapiens
Ligand
ADM
Function
Agonist
Reference
10.1021/ACSPTSCI.9B00080

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Ligand Amino Acid Generic Number Segment Interaction Type
ADM W72 N-term aromatic (face-to-edge)
ADM F92 N-term hydrophobic
ADM Q93 N-term polar (hydrogen bond)
ADM Q93 N-term polar (hydrogen bond with backbone)
ADM Q93 N-term Van der Waals
ADM D94 N-term Van der Waals
ADM D96 N-term Van der Waals
ADM P97 N-term Van der Waals
ADM P97 N-term hydrophobic
ADM H114 N-term Van der Waals
ADM S117 N-term Van der Waals
ADM S117 N-term polar (hydrogen bond)
ADM W121 N-term polar (hydrogen bond)
ADM W121 N-term Van der Waals
ADM T122 N-term Van der Waals
ADM Y124 N-term hydrophobic
ADM Y124 N-term Van der Waals
ADM T125 N-term Van der Waals
ADM N128 N-term polar (hydrogen bond)
ADM V135 1.33x33 TM1 hydrophobic
ADM V135 1.33x33 TM1 Van der Waals
ADM A138 1.36x36 TM1 Van der Waals
ADM L141 1.39x39 TM1 Van der Waals
ADM L141 1.39x39 TM1 hydrophobic
ADM F142 1.40x40 TM1 hydrophobic
ADM F142 1.40x40 TM1 Van der Waals
ADM T145 1.43x43 TM1 Van der Waals
ADM L195 2.68x68 TM2 hydrophobic
ADM L195 2.68x68 TM2 Van der Waals
ADM A199 ECL1 polar (hydrogen bond with backbone)
ADM A199 ECL1 Van der Waals
ADM N200 ECL1 Van der Waals
ADM Q202 ECL1 Van der Waals
ADM Q202 ECL1 polar (hydrogen bond)
ADM V205 ECL1 hydrophobic
ADM V205 ECL1 Van der Waals
ADM Q216 3.33x33 TM3 polar (hydrogen bond)
ADM Q216 3.33x33 TM3 Van der Waals
ADM H219 3.36x36 TM3 Van der Waals
ADM L220 3.37x37 TM3 Van der Waals
ADM Y227 3.44x44 TM3 Van der Waals
ADM I284 45.52x52 ECL2 hydrophobic
ADM I284 45.52x52 ECL2 Van der Waals
ADM S285 ECL2 Van der Waals
ADM S286 ECL2 polar (hydrogen bond with backbone)
ADM S286 ECL2 Van der Waals
ADM S286 ECL2 polar (hydrogen bond)
ADM D287 ECL2 Van der Waals
ADM L291 5.36x37 TM5 hydrophobic
ADM L291 5.36x37 TM5 Van der Waals
ADM Y292 5.37x38 TM5 polar (hydrogen bond)
ADM H295 5.40x40 TM5 polar (hydrogen bond)
ADM F349 6.53x53 TM6 hydrophobic
ADM F349 6.53x53 TM6 Van der Waals
ADM M369 7.42x41 TM7 Van der Waals
ADM H370 7.43x42 TM7 Van der Waals
ADM M373 7.46x45 TM7 Van der Waals

ADM

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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L Y F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
Helix box plot — Download: PNG | SVG L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7

GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x29 1.33x33 V135
1x32 1.36x36 A138
1x35 1.39x39 L141
1x36 1.40x40 F142
1x39 1.43x43 T145
TM2
2x61 2.68x68 L195
TM3
3x29 3.33x33 Q216
3x32 3.36x36 H219
3x33 3.37x37 L220
3x40 3.44x44 Y227
ECL2
45x52 45.52x52 I284
TM5
5x41 5.36x37 L291
5x42 5.37x38 Y292
5x44 5.40x40 H295
TM6
6x48 6.53x53 F349
TM7
7x37 7.42x41 M369
7x38 7.43x42 H370
7x41 7.46x45 M373