PDB
6UVA
Resolution
2.3 Å
Released
April 1, 2020
Receptor
calcitonin-like
Class
B1
Species
Homo sapiens
Ligand
ADM2 (Adrenomedullin 2 / Intermedin)
Function
Agonist
Reference
10.1021/ACSPTSCI.9B00080

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Ligand Amino Acid Generic Number Segment Interaction Type
ADM2 (Adrenomedullin 2 / Intermedin) V36 N-term hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) V36 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) T37 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) D70 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) W72 N-term aromatic (face-to-edge)
ADM2 (Adrenomedullin 2 / Intermedin) W72 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) D90 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) D90 N-term polar (charge-assisted hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) Y91 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) Y91 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) F92 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) F92 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Q93 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) Q93 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) Q93 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) D96 N-term polar (charge-assisted hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) P97 N-term hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) P97 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) S98 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) A116 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) S117 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) S117 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) T120 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) T120 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) W121 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) W121 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) T122 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Y124 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Y124 N-term polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) T125 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) N128 N-term Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) N128 N-term polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) K134 1.32x32 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) V135 1.33x33 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) V135 1.33x33 TM1 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) A138 1.36x36 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) A138 1.36x36 TM1 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) L139 1.37x37 TM1 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) L139 1.37x37 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) L141 1.39x39 TM1 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) L141 1.39x39 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) F142 1.40x40 TM1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) F142 1.40x40 TM1 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) T191 2.64x64 TM2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) L195 2.68x68 TM2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) L195 2.68x68 TM2 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) A199 ECL1 polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) A199 ECL1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) N200 ECL1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Q202 ECL1 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Q216 3.33x33 TM3 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) H219 3.36x36 TM3 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) L220 3.37x37 TM3 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) Y227 3.44x44 TM3 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) I284 45.52x52 ECL2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) I284 45.52x52 ECL2 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) S285 ECL2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) S286 ECL2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) S286 ECL2 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) D287 ECL2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) H289 ECL2 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) H289 ECL2 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) L291 5.36x37 TM5 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) Y292 5.37x38 TM5 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) Y292 5.37x38 TM5 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) H295 5.40x40 TM5 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) I298 5.43x43 TM5 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) F349 6.53x53 TM6 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) W354 ECL3 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) W354 ECL3 polar (hydrogen bond with backbone)
ADM2 (Adrenomedullin 2 / Intermedin) M369 7.42x41 TM7 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) M369 7.42x41 TM7 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) H370 7.43x42 TM7 polar (hydrogen bond)
ADM2 (Adrenomedullin 2 / Intermedin) H370 7.43x42 TM7 Van der Waals
ADM2 (Adrenomedullin 2 / Intermedin) M373 7.46x45 TM7 hydrophobic
ADM2 (Adrenomedullin 2 / Intermedin) M373 7.46x45 TM7 Van der Waals

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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L Y F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
Helix box plot — Download: PNG | SVG L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7

GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x28 1.32x32 K134
1x29 1.33x33 V135
1x32 1.36x36 A138
1x33 1.37x37 L139
1x35 1.39x39 L141
1x36 1.40x40 F142
TM2
2x57 2.64x64 T191
2x61 2.68x68 L195
TM3
3x29 3.33x33 Q216
3x32 3.36x36 H219
3x33 3.37x37 L220
3x40 3.44x44 Y227
ECL2
45x52 45.52x52 I284
TM5
5x41 5.36x37 L291
5x42 5.37x38 Y292
5x44 5.40x40 H295
5x47 5.43x43 I298
TM6
6x48 6.53x53 F349
TM7
7x37 7.42x41 M369
7x38 7.43x42 H370
7x41 7.46x45 M373