PDB
6WGT
Resolution
3.4 Å
Released
Sept. 23, 2020
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Function
(+)-LSD
Agonist (partial)
Reference
10.1016/J.CELL.2020.08.024

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Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD W151 3.28x28 TM3 hydrophobic
(+)-LSD D155 3.32x32 TM3 polar (hydrogen bond)
(+)-LSD D155 3.32x32 TM3 polar (charge-charge)
(+)-LSD V156 3.33x33 TM3 hydrophobic
(+)-LSD S159 3.36x36 TM3 Van der Waals
(+)-LSD C227 45.50x50 ECL2 Van der Waals
(+)-LSD L228 45.51x51 ECL2 Van der Waals
(+)-LSD L229 45.52x52 ECL2 hydrophobic
(+)-LSD F234 5.38x39 TM5 Van der Waals
(+)-LSD V235 5.39x40 TM5 Van der Waals
(+)-LSD G238 5.42x43 TM5 Van der Waals
(+)-LSD S242 5.46x461 TM5 polar (hydrogen bond)
(+)-LSD W336 6.48x48 TM6 Van der Waals
(+)-LSD F339 6.51x51 TM6 hydrophobic
(+)-LSD F340 6.52x52 TM6 hydrophobic
(+)-LSD F340 6.52x52 TM6 aromatic (edge-to-face)
(+)-LSD N343 6.55x55 TM6 Van der Waals
(+)-LSD V366 7.39x38 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
ECL2
45x50 45.50x50 C227
45x51 45.51x51 L228
45x52 45.52x52 L229
TM5
5x39 5.38x39 F234
5x40 5.39x40 V235
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x38 7.39x38 V366