Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6WPW

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABA3373

PUBLICATION DATE

Aug. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Glucagon derivative ZP3780 V28 N-term polar (hydrogen bond with backbone)
Glucagon derivative ZP3780 V28 N-term Van der Waals
Glucagon derivative ZP3780 M29 N-term polar (hydrogen bond with backbone)
Glucagon derivative ZP3780 M29 N-term Van der Waals
Glucagon derivative ZP3780 L32 N-term hydrophobic
Glucagon derivative ZP3780 L32 N-term Van der Waals
Glucagon derivative ZP3780 F33 N-term hydrophobic
Glucagon derivative ZP3780 W36 N-term hydrophobic
Glucagon derivative ZP3780 W36 N-term Van der Waals
Glucagon derivative ZP3780 K64 N-term Van der Waals
Glucagon derivative ZP3780 Y84 N-term Van der Waals
Glucagon derivative ZP3780 L85 N-term Van der Waals
Glucagon derivative ZP3780 W87 N-term Van der Waals
Glucagon derivative ZP3780 W87 N-term hydrophobic
Glucagon derivative ZP3780 P114 N-term Van der Waals
Glucagon derivative ZP3780 R116 N-term polar (charge-assisted hydrogen bond)
Glucagon derivative ZP3780 Q122 N-term Van der Waals
Glucagon derivative ZP3780 Q122 N-term polar (hydrogen bond)
Glucagon derivative ZP3780 M123 N-term polar (hydrogen bond)
Glucagon derivative ZP3780 Q131 1.29x29 TM1 polar (hydrogen bond)
Glucagon derivative ZP3780 Q131 1.29x29 TM1 polar (hydrogen bond)
Glucagon derivative ZP3780 Q131 1.29x29 TM1 polar (hydrogen bond with backbone)
Glucagon derivative ZP3780 V134 1.32x32 TM1 hydrophobic
Glucagon derivative ZP3780 V134 1.32x32 TM1 Van der Waals
Glucagon derivative ZP3780 A135 1.33x33 TM1 Van der Waals
Glucagon derivative ZP3780 A135 1.33x33 TM1 hydrophobic
Glucagon derivative ZP3780 Y138 1.36x36 TM1 hydrophobic
Glucagon derivative ZP3780 Y138 1.36x36 TM1 Van der Waals
Glucagon derivative ZP3780 F141 1.39x39 TM1 hydrophobic
Glucagon derivative ZP3780 F141 1.39x39 TM1 Van der Waals
Glucagon derivative ZP3780 Q142 1.40x40 TM1 Van der Waals
Glucagon derivative ZP3780 Q142 1.40x40 TM1 polar (hydrogen bond)
Glucagon derivative ZP3780 Y145 1.43x43 TM1 hydrophobic
Glucagon derivative ZP3780 Y145 1.43x43 TM1 Van der Waals
Glucagon derivative ZP3780 Y149 1.47x47 TM1 polar (hydrogen bond)
Glucagon derivative ZP3780 Y149 1.47x47 TM1 Van der Waals
Glucagon derivative ZP3780 V191 2.64x64 TM2 hydrophobic
Glucagon derivative ZP3780 V191 2.64x64 TM2 Van der Waals
Glucagon derivative ZP3780 L198 2.71x71 TM2 Van der Waals
Glucagon derivative ZP3780 L198 2.71x71 TM2 hydrophobic
Glucagon derivative ZP3780 R201 2.74x74 TM2 Van der Waals
Glucagon derivative ZP3780 R201 2.74x74 TM2 polar (hydrogen bond with backbone)
Glucagon derivative ZP3780 Y202 2.75x75 TM2 Van der Waals
Glucagon derivative ZP3780 Y202 2.75x75 TM2 hydrophobic
Glucagon derivative ZP3780 K205 ECL1 Van der Waals
Glucagon derivative ZP3780 K205 ECL1 polar (hydrogen bond with backbone)
Glucagon derivative ZP3780 I206 ECL1 hydrophobic
Glucagon derivative ZP3780 I206 ECL1 Van der Waals
Glucagon derivative ZP3780 G207 ECL1 Van der Waals
Glucagon derivative ZP3780 W215 ECL1 hydrophobic
Glucagon derivative ZP3780 W215 ECL1 Van der Waals
Glucagon derivative ZP3780 Q232 3.37x37 TM3 polar (hydrogen bond)
Glucagon derivative ZP3780 I235 3.40x40 TM3 Van der Waals
Glucagon derivative ZP3780 I235 3.40x40 TM3 hydrophobic
Glucagon derivative ZP3780 Q293 ECL2 Van der Waals
Glucagon derivative ZP3780 T296 45.52x52 ECL2 polar (hydrogen bond)
Glucagon derivative ZP3780 T296 45.52x52 ECL2 Van der Waals
Glucagon derivative ZP3780 S297 ECL2 Van der Waals
Glucagon derivative ZP3780 N298 ECL2 Van der Waals
Glucagon derivative ZP3780 W304 5.36x37 TM5 hydrophobic
Glucagon derivative ZP3780 W304 5.36x37 TM5 Van der Waals
Glucagon derivative ZP3780 V311 5.43x43 TM5 Van der Waals
Glucagon derivative ZP3780 V311 5.43x43 TM5 hydrophobic
Glucagon derivative ZP3780 D370 ECL3 polar (charge-assisted hydrogen bond)
Glucagon derivative ZP3780 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Glucagon derivative ZP3780 K381 7.38x37 TM7 Van der Waals
Glucagon derivative ZP3780 L382 7.39x38 TM7 hydrophobic
Glucagon derivative ZP3780 L382 7.39x38 TM7 Van der Waals
Glucagon derivative ZP3780 D385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Glucagon derivative ZP3780 L386 7.43x42 TM7 hydrophobic
Glucagon derivative ZP3780 L386 7.43x42 TM7 Van der Waals

Ligands

Glucagon derivative ZP3780

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x28 1.32x32 V134
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x64 2.71x71 L198
2x67 2.74x74 R201
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x47 5.43x43 V311
TM7
7x30 7.35x34 R378
7x33 7.38x37 K381
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386