PDB
6WWZ
Resolution
3.3 Å
Released
June 24, 2020
Receptor
CCR6
Class
A
Species
Homo sapiens
Ligand
Function
CCL20
Agonist
Reference
10.1038/S41467-020-16820-6

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Ligand Amino Acid Generic Number Segment Interaction Type
CCL20 Y27 N-term hydrophobic
CCL20 V29 N-term Van der Waals
CCL20 E32 N-term Van der Waals
CCL20 M33 N-term Van der Waals
CCL20 L34 N-term Van der Waals
CCL20 L35 N-term polar (hydrogen bond with backbone)
CCL20 C36 N-term hydrophobic
CCL20 L38 N-term Van der Waals
CCL20 V41 1.27x27 TM1 Van der Waals
CCL20 R42 1.28x28 TM1 polar (hydrogen bond)
CCL20 Y189 ECL2 hydrophobic
CCL20 T191 ECL2 Van der Waals
CCL20 Q192 ECL2 Van der Waals
CCL20 V196 ECL2 Van der Waals
CCL20 C197 45.50x50 ECL2 polar (hydrogen bond with backbone)
CCL20 E198 45.51x51 ECL2 polar (hydrogen bond)
CCL20 E198 45.51x51 ECL2 polar (charge-charge)
CCL20 K200 ECL2 polar (hydrogen bond)
CCL20 K200 ECL2 polar (charge-charge)
CCL20 Y201 ECL2 polar (hydrogen bond with backbone)
CCL20 P207 5.31x32 TM5 Van der Waals
CCL20 I208 5.32x33 TM5 Van der Waals
CCL20 K211 5.35x36 TM5 Van der Waals
CCL20 L281 ECL3 Van der Waals
CCL20 M284 ECL3 hydrophobic
CCL20 R286 ECL3 polar (hydrogen bond)
CCL20 R286 ECL3 polar (charge-charge)
CCL20 R286 ECL3 hydrophobic
CCL20 S287 7.24x23 TM7 Van der Waals
CCL20 C288 7.25x24 TM7 Van der Waals
CCL20 G295 7.32x31 TM7 Van der Waals
CCL20 K298 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K A R ICL1ECL1 A W V F ECL1ICL2 A T K S F R L R S R ICL2ECL2 Q K Y N T Q G S D V C E P K Y Q T V S E ECL2ICL3 Q N ICL3ECL3 N R ECL3N-term M S G E S M N F S D V F D S S E D Y F V S V N T S Y Y S V D S E M L L C S L N-termC-term C V R R K Y K S S G F S C A G R Y S E N I S R Q T S E T A D N D N A S S F T M C-term Q E V R Q F S R L F V P I A Y S L I C V F G L L G N I L V V I T F A F Y S M T D V Y L L N M A I A D I L F V L T L P F W A V S H A T G S N A T C K L L K G I Y A I N F N C G M L L L T C I S M D R Y I A I V Q T L P R S K I I C L V V W G L S V I I S S S T F V F N P I R W K L L M L G L E L L F G F F I P L M F M I F C Y T F I V K T L V Q A S K R H K A I R V I I A V V L V F L A C Q I P H N M V L L V T A A N L G K M S C Q S E K L I G Y T K T V T E V L A F L H C C L N P V L Y A F I G Q K F L K L W F R N Y I L K D
Helix box plot — Download: PNG | SVG I N G L L G F V C I L S Y A I P V F L R 1 L N M A I A D I L F V L T L P F W A V S 2 C T L L L M G C N F N I A Y I G K L L K 3 S K I I C L V V W G L S V I I S S S T 4 Y C F I M F M L P I F F G F L L E L G L M 5 I A V V L V F L A C Q I P H N M V L L V 6 V P N L C C H L F A L V E T V T K T Y 7

GPCRdb(A)
GPCRdb(A)
CCR6
TM1
1x27 1.27x27 V41
1x28 1.28x28 R42
ECL2
45x50 45.50x50 C197
45x51 45.51x51 E198
TM5
5x32 5.31x32 P207
5x33 5.32x33 I208
5x36 5.35x36 K211
TM7
7x23 7.24x23 S287
7x24 7.25x24 C288
7x31 7.32x31 G295
7x34 7.35x34 K298