PDB
6X19
Resolution
2.1 Å
Released
Sept. 9, 2020
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
CHU-128
Agonist
Reference
10.1016/J.MOLCEL.2020.09.020

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Ligand Amino Acid Generic Number Segment Interaction Type
CHU-128 S31 N-term Van der Waals
CHU-128 W33 N-term hydrophobic
CHU-128 E34 N-term Van der Waals
CHU-128 P137 N-term hydrophobic
CHU-128 E138 N-term hydrophobic
CHU-128 L141 1.36x36 TM1 hydrophobic
CHU-128 L144 1.39x39 TM1 hydrophobic
CHU-128 Y145 1.40x40 TM1 hydrophobic
CHU-128 Y145 1.40x40 TM1 aromatic (edge-to-face)
CHU-128 Y148 1.43x43 TM1 Van der Waals
CHU-128 K197 2.67x67 TM2 aromatic (pi-cation)
CHU-128 K197 2.67x67 TM2 polar (charge-charge)
CHU-128 D198 2.68x68 TM2 Van der Waals
CHU-128 A200 2.70x70 TM2 Van der Waals
CHU-128 L201 2.71x71 TM2 Van der Waals
CHU-128 K202 2.72x72 TM2 Van der Waals
CHU-128 M204 2.74x74 TM2 Van der Waals
CHU-128 Y205 2.75x75 TM2 Van der Waals
CHU-128 Y220 ECL1 polar (hydrogen bond)
CHU-128 C226 3.29x29 TM3 hydrophobic
CHU-128 V229 3.32x32 TM3 hydrophobic
CHU-128 F230 3.33x33 TM3 hydrophobic
CHU-128 F230 3.33x33 TM3 aromatic (edge-to-face)
CHU-128 M233 3.36x36 TM3 hydrophobic
CHU-128 T298 45.52x52 ECL2 hydrophobic
CHU-128 N300 ECL2 Van der Waals
CHU-128 L384 7.39x38 TM7 Van der Waals
CHU-128 L388 7.43x42 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x60 2.67x67 K197
2x61 2.68x68 D198
2x63 2.70x70 A200
2x64 2.71x71 L201
2x65 2.72x72 K202
2x67 2.74x74 M204
2x68 2.75x75 Y205
TM3
3x25 3.29x29 C226
3x28 3.32x32 V229
3x29 3.33x33 F230
3x32 3.36x36 M233
ECL2
45x52 45.52x52 T298
TM7
7x34 7.39x38 L384
7x38 7.43x42 L388