PDB
6ZG9
Resolution
2.5 Å
Released
Oct. 6, 2021
Receptor
M1
Class
A
Species
Homo sapiens
Ligand
GSK1034702
Function
Agonist
Reference
10.1016/J.CELL.2021.11.001

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Ligand Amino Acid Generic Number Segment Interaction Type
GSK1034702 L81 2.60x59 TM2 hydrophobic
GSK1034702 Y82 2.61x60 TM2 hydrophobic
GSK1034702 Y85 2.64x63 TM2 hydrophobic
GSK1034702 L102 3.29x29 TM3 hydrophobic
GSK1034702 D105 3.32x32 TM3 polar (charge-assisted hydrogen bond)
GSK1034702 S109 3.36x36 TM3 Van der Waals
GSK1034702 C178 45.50x50 ECL2 polar (hydrogen bond with backbone)
GSK1034702 C178 45.50x50 ECL2 Van der Waals
GSK1034702 Y179 45.51x51 ECL2 Van der Waals
GSK1034702 W378 6.48x48 TM6 hydrophobic
GSK1034702 W378 6.48x48 TM6 Van der Waals
GSK1034702 Y381 6.51x51 TM6 Van der Waals
GSK1034702 Y404 7.39x38 TM7 hydrophobic
GSK1034702 Y404 7.39x38 TM7 Van der Waals
GSK1034702 Y408 7.43x42 TM7 Van der Waals

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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
Helix box plot — Download: PNG | SVG L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7

GPCRdb(A)
GPCRdb(A)
M1 receptor
TM2
2x59 2.60x59 L81
2x60 2.61x60 Y82
2x63 2.64x63 Y85
TM3
3x29 3.29x29 L102
3x32 3.32x32 D105
3x36 3.36x36 S109
ECL2
45x50 45.50x50 C178
45x51 45.51x51 Y179
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
TM7
7x38 7.39x38 Y404
7x42 7.43x42 Y408