PDB
7BZ2
Resolution
3.8 Å
Released
Aug. 5, 2020
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
Function
ARFORMOTEROL
Agonist
Reference
10.1038/S41421-020-0176-9

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Ligand Amino Acid Generic Number Segment Interaction Type
ARFORMOTEROL H93 2.64x63 TM2 Van der Waals
ARFORMOTEROL W109 3.28x28 TM3 hydrophobic
ARFORMOTEROL T110 3.29x29 TM3 Van der Waals
ARFORMOTEROL D113 3.32x32 TM3 polar (charge-charge)
ARFORMOTEROL V114 3.33x33 TM3 hydrophobic
ARFORMOTEROL V117 3.36x36 TM3 hydrophobic
ARFORMOTEROL D192 45.51x51 ECL2 Van der Waals
ARFORMOTEROL F193 45.52x52 ECL2 aromatic (pi-cation)
ARFORMOTEROL F193 45.52x52 ECL2 hydrophobic
ARFORMOTEROL Y199 5.38x39 TM5 Van der Waals
ARFORMOTEROL A200 5.39x40 TM5 Van der Waals
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S207 5.46x461 TM5 Van der Waals
ARFORMOTEROL F289 6.51x51 TM6 Van der Waals
ARFORMOTEROL F290 6.52x52 TM6 aromatic (edge-to-face)
ARFORMOTEROL F290 6.52x52 TM6 hydrophobic
ARFORMOTEROL Y308 7.35x34 TM7 hydrophobic
ARFORMOTEROL N312 7.39x38 TM7 Van der Waals
ARFORMOTEROL Y316 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM2
2x63 2.64x63 H93
TM3
3x28 3.28x28 W109
3x29 3.29x29 T110
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x39 5.38x39 Y199
5x40 5.39x40 A200
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x34 7.35x34 Y308
7x38 7.39x38 N312
7x42 7.43x42 Y316