PDB
7C2E
Resolution
4.2 Å
Released
Aug. 26, 2020
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
RGT1383
Function
Agonist
Reference
10.1038/S41422-020-0384-8

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Ligand Amino Acid Generic Number Segment Interaction Type
RGT1383 L32 N-term Van der Waals
RGT1383 L32 N-term polar (hydrogen bond with backbone)
RGT1383 W33 N-term hydrophobic
RGT1383 W33 N-term Van der Waals
RGT1383 V36 N-term Van der Waals
RGT1383 V36 N-term hydrophobic
RGT1383 Q37 N-term polar (hydrogen bond)
RGT1383 L141 1.36x36 TM1 Van der Waals
RGT1383 L201 ECL1 Van der Waals
RGT1383 L201 ECL1 hydrophobic
RGT1383 L218 ECL1 hydrophobic
RGT1383 L218 ECL1 Van der Waals
RGT1383 D222 ECL1 Van der Waals
RGT1383 F230 3.33x33 TM3 aromatic (edge-to-face)
RGT1383 F230 3.33x33 TM3 Van der Waals
RGT1383 C296 45.50x50 ECL2 Van der Waals
RGT1383 C296 45.50x50 ECL2 hydrophobic
RGT1383 T298 45.52x52 ECL2 Van der Waals
RGT1383 T298 45.52x52 ECL2 polar (hydrogen bond)
RGT1383 R380 7.35x34 TM7 Van der Waals
RGT1383 F381 7.36x35 TM7 hydrophobic
RGT1383 F381 7.36x35 TM7 Van der Waals
RGT1383 L384 7.39x38 TM7 hydrophobic
RGT1383 L384 7.39x38 TM7 Van der Waals
RGT1383 F385 7.40x39 TM7 hydrophobic

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
TM3
3x29 3.33x33 F230
ECL2
45x50 45.50x50 C296
45x52 45.52x52 T298
TM7
7x30 7.35x34 R380
7x31 7.36x35 F381
7x34 7.39x38 L384
7x35 7.40x39 F385