Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CKX

SPECIES

Homo sapiens

RESOLUTION

3.540

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.028

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
A77636 V100 3.29x29 TM3 hydrophobic
A77636 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
A77636 I104 3.33x33 TM3 hydrophobic
A77636 I104 3.33x33 TM3 Van der Waals
A77636 S107 3.36x36 TM3 polar (hydrogen bond)
A77636 S188 45.52x52 ECL2 Van der Waals
A77636 L190 ECL2 Van der Waals
A77636 L190 ECL2 hydrophobic
A77636 S198 5.42x43 TM5 polar (hydrogen bond with backbone)
A77636 S198 5.42x43 TM5 polar (hydrogen bond)
A77636 S198 5.42x43 TM5 Van der Waals
A77636 S199 5.43x44 TM5 Van der Waals
A77636 S199 5.43x44 TM5 polar (hydrogen bond with backbone)
A77636 S202 5.46x461 TM5 Van der Waals
A77636 W285 6.48x48 TM6 Van der Waals
A77636 F288 6.51x51 TM6 hydrophobic
A77636 F288 6.51x51 TM6 Van der Waals
A77636 F289 6.52x52 TM6 aromatic (edge-to-face)
A77636 F289 6.52x52 TM6 Van der Waals
A77636 N292 6.55x55 TM6 Van der Waals
A77636 F313 7.35x34 TM7 Van der Waals
A77636 F313 7.35x34 TM7 hydrophobic
A77636 W321 7.43x42 TM7 Van der Waals

Ligands

A77636

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x29 3.29x29 V100
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x42 7.43x42 W321