Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CKY

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.028

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3697578 K81 2.61x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL3697578 W99 3.28x28 TM3 aromatic (edge-to-face)
CHEMBL3697578 W99 3.28x28 TM3 Van der Waals
CHEMBL3697578 V100 3.29x29 TM3 Van der Waals
CHEMBL3697578 V100 3.29x29 TM3 hydrophobic
CHEMBL3697578 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL3697578 I104 3.33x33 TM3 Van der Waals
CHEMBL3697578 I104 3.33x33 TM3 hydrophobic
CHEMBL3697578 S107 3.36x36 TM3 Van der Waals
CHEMBL3697578 C186 45.50x50 ECL2 Van der Waals
CHEMBL3697578 C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
CHEMBL3697578 D187 45.51x51 ECL2 polar (hydrogen bond with backbone)
CHEMBL3697578 D187 45.51x51 ECL2 Van der Waals
CHEMBL3697578 S188 45.52x52 ECL2 Van der Waals
CHEMBL3697578 S188 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL3697578 S189 ECL2 Van der Waals
CHEMBL3697578 L190 ECL2 hydrophobic
CHEMBL3697578 L190 ECL2 Van der Waals
CHEMBL3697578 S198 5.42x43 TM5 polar (hydrogen bond with backbone)
CHEMBL3697578 S198 5.42x43 TM5 polar (hydrogen bond)
CHEMBL3697578 S199 5.43x44 TM5 polar (hydrogen bond)
CHEMBL3697578 S199 5.43x44 TM5 polar (hydrogen bond with backbone)
CHEMBL3697578 S202 5.46x461 TM5 polar (hydrogen bond)
CHEMBL3697578 F288 6.51x51 TM6 hydrophobic
CHEMBL3697578 F288 6.51x51 TM6 Van der Waals
CHEMBL3697578 F289 6.52x52 TM6 hydrophobic
CHEMBL3697578 F289 6.52x52 TM6 Van der Waals
CHEMBL3697578 N292 6.55x55 TM6 polar (hydrogen bond)
CHEMBL3697578 F313 7.35x34 TM7 hydrophobic

Ligands

CHEMBL3697578

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM2
2x60 2.61x60 K81
TM3
3x28 3.28x28 W99
3x29 3.29x29 V100
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x50 45.50x50 C186
45x51 45.51x51 D187
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313