PDB
7CKZ
Resolution
3.1 Å
Released
March 3, 2021
Receptor
D1
Class
A
Species
Homo sapiens
Ligands
dopamine
mevidalen
Function
Agonist
PAM
Reference
10.1016/J.CELL.2021.01.028
dopamine mevidalen

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Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dopamine I104 3.33x33 TM3 hydrophobic
dopamine I104 3.33x33 TM3 Van der Waals
dopamine S107 3.36x36 TM3 polar (hydrogen bond)
dopamine T108 3.37x37 TM3 Van der Waals
mevidalen L112 3.41x41 TM3 hydrophobic
mevidalen C115 3.44x44 TM3 Van der Waals
mevidalen C115 3.44x44 TM3 polar (hydrogen bond)
mevidalen V119 3.48x48 TM3 Van der Waals
mevidalen V119 3.48x48 TM3 hydrophobic
mevidalen W123 3.52x52 TM3 hydrophobic
mevidalen W123 3.52x52 TM3 Van der Waals
mevidalen R130 34.52x52 ICL2 Van der Waals
mevidalen L143 4.45x45 TM4 Van der Waals
mevidalen L143 4.45x45 TM4 hydrophobic
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S198 5.42x43 TM5 Van der Waals
dopamine S199 5.43x44 TM5 Van der Waals
dopamine S202 5.46x461 TM5 Van der Waals
dopamine S202 5.46x461 TM5 polar (hydrogen bond)
mevidalen I209 5.53x53 TM5 hydrophobic
mevidalen I209 5.53x53 TM5 Van der Waals
dopamine F288 6.51x51 TM6 aromatic (edge-to-face)
dopamine F288 6.51x51 TM6 Van der Waals
dopamine F289 6.52x52 TM6 aromatic (edge-to-face)
dopamine F289 6.52x52 TM6 Van der Waals
dopamine N292 6.55x55 TM6 Van der Waals
dopamine W321 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 T108
3x41 3.41x41 L112
3x44 3.44x44 C115
3x48 3.48x48 V119
3x52 3.52x52 W123
ICL2
34x52 34.52x52 R130
TM4
4x45 4.45x45 L143
TM5
5x43 5.42x43 S198
5x44 5.43x44 S199
5x461 5.46x461 S202
5x53 5.53x53 I209
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x42 7.43x42 W321