PDB
7CX2
Resolution
2.8 Å
Released
May 5, 2021
Receptor
EP2
Class
A
Species
Homo sapiens
Ligand
PGE2
Function
Agonist
Reference
10.1126/SCIADV.ABF1268

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Ligand Amino Acid Generic Number Segment Interaction Type
PGE2 S28 1.39x39 TM1 polar (hydrogen bond)
PGE2 S28 1.39x39 TM1 polar (hydrogen bond)
PGE2 M31 1.42x42 TM1 hydrophobic
PGE2 M31 1.42x42 TM1 Van der Waals
PGE2 T82 2.54x54 TM2 polar (hydrogen bond)
PGE2 I85 2.57x57 TM2 Van der Waals
PGE2 I85 2.57x57 TM2 hydrophobic
PGE2 S86 2.58x58 TM2 polar (hydrogen bond)
PGE2 S86 2.58x58 TM2 Van der Waals
PGE2 Y93 2.65x65 TM2 polar (hydrogen bond)
PGE2 Y93 2.65x65 TM2 polar (hydrogen bond)
PGE2 M116 3.32x32 TM3 hydrophobic
PGE2 M116 3.32x32 TM3 Van der Waals
PGE2 T123 3.39x39 TM3 Van der Waals
PGE2 T185 ECL2 polar (hydrogen bond)
PGE2 T185 ECL2 Van der Waals
PGE2 L298 7.36x35 TM7 hydrophobic
PGE2 L298 7.36x35 TM7 Van der Waals
PGE2 R302 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE2 L304 7.42x41 TM7 hydrophobic
PGE2 L304 7.42x41 TM7 Van der Waals
PGE2 S305 7.43x42 TM7 polar (hydrogen bond)
PGE2 N307 7.45x45 TM7 Van der Waals
PGE2 S308 7.46x46 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
Helix box plot — Download: PNG | SVG L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7

GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x65 2.65x65 Y93
TM3
3x32 3.32x32 M116
3x39 3.39x39 T123
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302
7x41 7.42x41 L304
7x42 7.43x42 S305
7x45 7.45x45 N307
7x46 7.46x46 S308