PDB
7CX4
Resolution
2.9 Å
Released
May 5, 2021
Receptor
EP2
Class
A
Species
Homo sapiens
Ligand
Function
evatanepag
Agonist
Reference
10.1126/SCIADV.ABF1268

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Ligand Amino Acid Generic Number Segment Interaction Type
evatanepag S28 1.39x39 TM1 polar (hydrogen bond)
evatanepag M31 1.42x42 TM1 hydrophobic
evatanepag T82 2.54x54 TM2 polar (hydrogen bond)
evatanepag I85 2.57x57 TM2 hydrophobic
evatanepag S86 2.58x58 TM2 polar (hydrogen bond)
evatanepag V89 2.61x61 TM2 Van der Waals
evatanepag Y93 2.65x65 TM2 polar (hydrogen bond)
evatanepag M116 3.32x32 TM3 hydrophobic
evatanepag F119 3.35x35 TM3 hydrophobic
evatanepag S120 3.36x36 TM3 Van der Waals
evatanepag T123 3.39x39 TM3 Van der Waals
evatanepag W186 ECL2 hydrophobic
evatanepag W186 ECL2 aromatic (edge-to-face)
evatanepag L298 7.36x35 TM7 hydrophobic
evatanepag L301 7.39x38 TM7 Van der Waals
evatanepag R302 7.40x39 TM7 polar (hydrogen bond)
evatanepag R302 7.40x39 TM7 polar (charge-charge)
evatanepag R302 7.40x39 TM7 aromatic (pi-cation)
evatanepag S305 7.43x42 TM7 Van der Waals
evatanepag S308 7.46x46 TM7 Van der Waals
evatanepag I309 7.47x47 TM7 hydrophobic

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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
Helix box plot — Download: PNG | SVG L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7

GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x61 2.61x61 V89
2x65 2.65x65 Y93
TM3
3x32 3.32x32 M116
3x35 3.35x35 F119
3x36 3.36x36 S120
3x39 3.39x39 T123
TM7
7x35 7.36x35 L298
7x38 7.39x38 L301
7x39 7.40x39 R302
7x42 7.43x42 S305
7x46 7.46x46 S308
7x47 7.47x47 I309