PDB
7CZ5
Resolution
2.6 Å
Released
Nov. 18, 2020
Receptor
GHRH
Class
B1
Species
Homo sapiens
Ligand
Function
GHRH (Human)
Agonist
Reference
10.1038/S41467-020-18945-0

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Ligand Amino Acid Generic Number Segment Interaction Type
GHRH (Human) L119 1.29x29 TM1 hydrophobic
GHRH (Human) E122 1.32x32 TM1 hydrophobic
GHRH (Human) E123 1.33x33 TM1 hydrophobic
GHRH (Human) F126 1.36x36 TM1 hydrophobic
GHRH (Human) S127 1.37x37 TM1 Van der Waals
GHRH (Human) V129 1.39x39 TM1 hydrophobic
GHRH (Human) K130 1.40x40 TM1 hydrophobic
GHRH (Human) Y133 1.43x43 TM1 hydrophobic
GHRH (Human) Y133 1.43x43 TM1 aromatic (edge-to-face)
GHRH (Human) V179 2.64x64 TM2 Van der Waals
GHRH (Human) K182 2.67x67 TM2 polar (hydrogen bond)
GHRH (Human) K182 2.67x67 TM2 polar (charge-charge)
GHRH (Human) L186 2.71x71 TM2 Van der Waals
GHRH (Human) F187 2.72x72 TM2 aromatic (edge-to-face)
GHRH (Human) F187 2.72x72 TM2 hydrophobic
GHRH (Human) D193 ECL1 Van der Waals
GHRH (Human) H194 ECL1 polar (hydrogen bond)
GHRH (Human) H194 ECL1 polar (hydrogen bond with backbone)
GHRH (Human) C195 ECL1 Van der Waals
GHRH (Human) H210 3.37x37 TM3 Van der Waals
GHRH (Human) T213 3.40x40 TM3 hydrophobic
GHRH (Human) A271 ECL2 polar (hydrogen bond with backbone)
GHRH (Human) C272 45.50x50 ECL2 Van der Waals
GHRH (Human) D274 45.52x52 ECL2 polar (hydrogen bond with backbone)
GHRH (Human) D274 45.52x52 ECL2 polar (charge-charge)
GHRH (Human) D276 ECL2 Van der Waals
GHRH (Human) W282 5.36x37 TM5 hydrophobic
GHRH (Human) I289 5.43x43 TM5 hydrophobic
GHRH (Human) D350 ECL3 Van der Waals
GHRH (Human) L354 7.35x34 TM7 hydrophobic
GHRH (Human) R357 7.38x37 TM7 Van der Waals
GHRH (Human) L358 7.39x38 TM7 hydrophobic
GHRH (Human) E361 7.42x41 TM7 polar (charge-charge)
GHRH (Human) L362 7.43x42 TM7 hydrophobic

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ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
Helix box plot — Download: PNG | SVG F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7

GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x25 1.29x29 L119
1x28 1.32x32 E122
1x29 1.33x33 E123
1x32 1.36x36 F126
1x33 1.37x37 S127
1x35 1.39x39 V129
1x36 1.40x40 K130
1x39 1.43x43 Y133
TM2
2x57 2.64x64 V179
2x60 2.67x67 K182
2x64 2.71x71 L186
2x65 2.72x72 F187
TM3
3x33 3.37x37 H210
3x36 3.40x40 T213
ECL2
45x50 45.50x50 C272
45x52 45.52x52 D274
TM5
5x41 5.36x37 W282
5x47 5.43x43 I289
TM7
7x30 7.35x34 L354
7x33 7.38x37 R357
7x34 7.39x38 L358
7x37 7.42x41 E361
7x38 7.43x42 L362