PDB
7D68
Resolution
3.0 Å
Released
Dec. 16, 2020
Receptor
GLP-2
Class
B1
Species
Homo sapiens
Ligand
glucagon-like peptide 2 (Human)
Function
Agonist
Reference
10.1038/S41422-020-00442-0

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Ligand Amino Acid Generic Number Segment Interaction Type
glucagon-like peptide 2 (Human) F165 N-term hydrophobic
glucagon-like peptide 2 (Human) N168 1.29x29 TM1 polar (hydrogen bond)
glucagon-like peptide 2 (Human) R171 1.32x32 TM1 Van der Waals
glucagon-like peptide 2 (Human) Y172 1.33x33 TM1 hydrophobic
glucagon-like peptide 2 (Human) Y172 1.33x33 TM1 Van der Waals
glucagon-like peptide 2 (Human) L175 1.36x36 TM1 Van der Waals
glucagon-like peptide 2 (Human) L175 1.36x36 TM1 hydrophobic
glucagon-like peptide 2 (Human) L178 1.39x39 TM1 hydrophobic
glucagon-like peptide 2 (Human) L178 1.39x39 TM1 Van der Waals
glucagon-like peptide 2 (Human) Q179 1.40x40 TM1 Van der Waals
glucagon-like peptide 2 (Human) Y182 1.43x43 TM1 aromatic (edge-to-face)
glucagon-like peptide 2 (Human) Y182 1.43x43 TM1 Van der Waals
glucagon-like peptide 2 (Human) Y186 1.47x47 TM1 polar (hydrogen bond)
glucagon-like peptide 2 (Human) Y186 1.47x47 TM1 Van der Waals
glucagon-like peptide 2 (Human) V228 2.64x64 TM2 hydrophobic
glucagon-like peptide 2 (Human) V228 2.64x64 TM2 Van der Waals
glucagon-like peptide 2 (Human) K231 2.67x67 TM2 polar (charge-assisted hydrogen bond)
glucagon-like peptide 2 (Human) F235 2.71x71 TM2 Van der Waals
glucagon-like peptide 2 (Human) F235 2.71x71 TM2 hydrophobic
glucagon-like peptide 2 (Human) Y239 2.75x75 TM2 hydrophobic
glucagon-like peptide 2 (Human) Y239 2.75x75 TM2 Van der Waals
glucagon-like peptide 2 (Human) R242 ECL1 polar (charge-assisted hydrogen bond)
glucagon-like peptide 2 (Human) D244 ECL1 polar (charge-assisted hydrogen bond)
glucagon-like peptide 2 (Human) E246 ECL1 Van der Waals
glucagon-like peptide 2 (Human) N247 ECL1 Van der Waals
glucagon-like peptide 2 (Human) W249 ECL1 Van der Waals
glucagon-like peptide 2 (Human) W249 ECL1 aromatic (face-to-edge)
glucagon-like peptide 2 (Human) H268 3.37x37 TM3 aromatic (face-to-edge)
glucagon-like peptide 2 (Human) H268 3.37x37 TM3 polar (hydrogen bond)
glucagon-like peptide 2 (Human) V271 3.40x40 TM3 Van der Waals
glucagon-like peptide 2 (Human) V271 3.40x40 TM3 hydrophobic
glucagon-like peptide 2 (Human) T332 45.52x52 ECL2 polar (hydrogen bond)
glucagon-like peptide 2 (Human) T333 ECL2 Van der Waals
glucagon-like peptide 2 (Human) N334 ECL2 Van der Waals
glucagon-like peptide 2 (Human) W340 5.36x37 TM5 Van der Waals
glucagon-like peptide 2 (Human) W340 5.36x37 TM5 hydrophobic
glucagon-like peptide 2 (Human) R344 5.40x40 TM5 Van der Waals
glucagon-like peptide 2 (Human) K414 7.35x34 TM7 polar (charge-assisted hydrogen bond)
glucagon-like peptide 2 (Human) R417 7.38x37 TM7 Van der Waals
glucagon-like peptide 2 (Human) L418 7.39x38 TM7 hydrophobic
glucagon-like peptide 2 (Human) L418 7.39x38 TM7 Van der Waals
glucagon-like peptide 2 (Human) Q421 7.42x41 TM7 Van der Waals
glucagon-like peptide 2 (Human) L422 7.43x42 TM7 hydrophobic
glucagon-like peptide 2 (Human) L422 7.43x42 TM7 Van der Waals

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ICL1 R K L H ICL1ECL1 S K R P D N E N G W M S Y L S E M S ECL1ICL2 T V L P E R R ICL2ECL2 N T G C W T T N G N K ECL2ICL3 A H Q M ICL3ECL3 I T D D Q V E ECL3N-term M K L G S S R A G P G R G S A G L L P G V H E L P M G I P A P W G T S P L S F H R K C S L W A P G R P F L T L V L L V S I K Q V T G S L L E E T T R K W A Q Y K Q A C L R D L L K E P S G I F C N G T F D Q Y V C W P H S S P G N V S V P C P S Y L P W W S E E S S G R A Y R H C L A Q G T W Q T I E N A T D I W Q D D S E C S E N H S F N-termC-term V L G K D F R F L G K C P K K L S E G D G A E K L R K L Q P S L N S G R L L H L A M R G L G E L G A Q P Q Q D H A R W P R G S S L S E C S E G D V T M A N T M E E I L E E S E I C-term K Q N V D R Y A L L S T L Q L M Y T V G Y S F S L I S L F L A L T L L L F L C T R N Y I H M N L F A S F I L R T L A V L V K D V V F Y N S Y T S C R S V Q V L L H Y F V G A N Y L W L L V E G L Y L H T L L E P L W P R Y L L L G W A F P V L F V V P W G F A R A H L E K I W W I I R G P M M L C V T V N F F I F L K I L K L L I S K L K C F R D Y K Y R L A K S T L V L I P L L G V H E I L F S F G F A K L I R L F I Q L T L S S F H G F L V A L Q Y G F A N G E L R K F L L G C R V K A E Y W V R A R H S A C
Helix box plot — Download: PNG | SVG F L S I L S F S Y G V T Y M L Q L T S L 1 M N L F A S F I L R T L A V L V K D V V 2 V L L W L Y N A G V F Y H L L V Q V S R 3 L W P R Y L L G L W A F P V L F V V P W G 4 F I F F N V T V C L M M P G R I I W W I K 5 L V L I P L L G V H E I L F S F 6 L A V L F G H F S S L T L Q I F L R I 7

GPCRdb(A)
GPCRdb(B)
GLP-2 receptor
TM1
1x25 1.29x29 N168
1x28 1.32x32 R171
1x29 1.33x33 Y172
1x32 1.36x36 L175
1x35 1.39x39 L178
1x36 1.40x40 Q179
1x39 1.43x43 Y182
1x43 1.47x47 Y186
TM2
2x57 2.64x64 V228
2x60 2.67x67 K231
2x64 2.71x71 F235
2x68 2.75x75 Y239
TM3
3x33 3.37x37 H268
3x36 3.40x40 V271
ECL2
45x52 45.52x52 T332
TM5
5x41 5.36x37 W340
5x44 5.40x40 R344
TM7
7x30 7.35x34 K414
7x33 7.38x37 R417
7x34 7.39x38 L418
7x37 7.42x41 Q421
7x38 7.43x42 L422