PDB
7D7M
Resolution
3.3 Å
Released
Nov. 18, 2020
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
PGE2
Function
Agonist
Reference
10.1016/J.STR.2020.11.007

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Ligand Amino Acid Generic Number Segment Interaction Type
PGE2 M27 1.42x42 TM1 polar (hydrogen bond)
PGE2 G68 2.53x53 TM2 Van der Waals
PGE2 T69 2.54x54 TM2 polar (hydrogen bond with backbone)
PGE2 T69 2.54x54 TM2 Van der Waals
PGE2 V72 2.57x57 TM2 polar (hydrogen bond with backbone)
PGE2 V72 2.57x57 TM2 Van der Waals
PGE2 S73 2.58x58 TM2 Van der Waals
PGE2 T76 2.61x61 TM2 Van der Waals
PGE2 T76 2.61x61 TM2 polar (hydrogen bond)
PGE2 Y80 2.65x65 TM2 polar (hydrogen bond)
PGE2 L99 3.32x32 TM3 Van der Waals
PGE2 S103 3.36x36 TM3 Van der Waals
PGE2 T168 ECL2 polar (hydrogen bond)
PGE2 W169 ECL2 hydrophobic
PGE2 W169 ECL2 Van der Waals
PGE2 L312 7.36x35 TM7 Van der Waals
PGE2 L312 7.36x35 TM7 hydrophobic
PGE2 I315 7.39x38 TM7 hydrophobic
PGE2 I315 7.39x38 TM7 Van der Waals
PGE2 R316 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE2 A318 7.42x41 TM7 hydrophobic
PGE2 A318 7.42x41 TM7 Van der Waals
PGE2 S319 7.43x42 TM7 Van der Waals

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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x42 1.42x42 M27
TM2
2x53 2.53x53 G68
2x54 2.54x54 T69
2x57 2.57x57 V72
2x58 2.58x58 S73
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
3x36 3.36x36 S103
TM7
7x35 7.36x35 L312
7x38 7.39x38 I315
7x39 7.40x39 R316
7x41 7.42x41 A318
7x42 7.43x42 S319