PDB
7DB6
Resolution
3.3 Å
Released
Aug. 18, 2021
Receptor
MT1
Class
A
Species
Homo sapiens
Ligand
Function
ramelteon
Agonist
Reference
10.1038/S41594-021-00634-1

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Ligand Amino Acid Generic Number Segment Interaction Type
ramelteon G104 3.29x29 TM3 Van der Waals
ramelteon M107 3.32x32 TM3 Van der Waals
ramelteon G108 3.33x33 TM3 Van der Waals
ramelteon V111 3.36x36 TM3 hydrophobic
ramelteon I112 3.37x37 TM3 hydrophobic
ramelteon L163 4.61x62 TM4 hydrophobic
ramelteon L168 ECL2 hydrophobic
ramelteon F179 45.52x52 ECL2 hydrophobic
ramelteon Q181 ECL2 polar (hydrogen bond)
ramelteon Q181 ECL2 hydrophobic
ramelteon T188 5.39x40 TM5 Van der Waals
ramelteon V191 5.42x43 TM5 hydrophobic
ramelteon V192 5.43x44 TM5 Van der Waals
ramelteon F196 5.47x47 TM5 Van der Waals
ramelteon W251 6.48x48 TM6 Van der Waals
ramelteon L254 6.51x51 TM6 Van der Waals
ramelteon N255 6.52x52 TM6 Van der Waals
ramelteon G258 6.55x55 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
Helix box plot — Download: PNG | SVG L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7

GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x29 3.29x29 G104
3x32 3.32x32 M107
3x33 3.33x33 G108
3x36 3.36x36 V111
3x37 3.37x37 I112
TM4
4x62 4.61x62 L163
ECL2
45x52 45.52x52 F179
TM5
5x40 5.39x40 T188
5x43 5.42x43 V191
5x44 5.43x44 V192
5x47 5.47x47 F196
TM6
6x48 6.48x48 W251
6x51 6.51x51 L254
6x52 6.52x52 N255
6x55 6.55x55 G258